938results about "Methine/polymethine dyes" patented technology

Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.

The invention discloses a molecular probe for in-vivo copper ion detection and a preparation method and application thereof, the chemical structural formula of the molecular probe is as follows: # imgabs0 #, the molecular probe provided by the invention can specifically respond to copper ions in a tumor subacid environment so as to cause change of an absorption spectrum, and a photoacoustic signal is started so as to detect the copper ions in the tumor subacid environment. Normal tissues and tumor tissues can be accurately distinguished, and accurate detection of the copper ions in the living tumor is realized.

An optical filter includes: a substrate, an antireflection layer 1 including a dielectric multilayer film laminated on one main surface side of the substrate, and an antireflection layer 2 including a dielectric multilayer film laminated on the other main surface side of the substrate. The substrate includes a near-infrared ray absorbing glass and a resin film, the resin film includes a resin, a UV dye having a maximum absorption wavelength in 350 nm to 410 nm in the resin, and an IR dye having a maximum absorption wavelength in 700 nm to 850 nm in the resin, and the optical filter satisfies all of the characteristics (i-1) to (i-7).

Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.

The present invention discloses a preparation method of yellow azoxy and azo stilbene dyes. Using 4-nitrotoluene-2-sulfonic acid as a raw material and water as a reaction solvent, in the presence of choline hydroxide, dye yellow 11 is obtained through a condensation reaction. The molecular structure of choline hydroxide contains a quaternary ammonium salt group and a hydroxyl group. The hydroxyl group provides additional hydrophilicity, which helps to improve the solubility and dispersibility of the dye in an aqueous medium and enhance the affinity between the dye and the fiber. Choline hydroxide can effectively provide the alkaline environment required for the reaction, promote the synthesis reaction of the dye, and better control the selectivity and yield of the reaction. Since the choline hydroxide molecule contains a hydroxyl group, it can form hydrogen bonds with the sulfonic acid groups in the dye molecule, enhance the stability between dye molecules, and improve the light fastness and acid and alkali resistance of the dye. Using choline hydroxide not only optimizes the reaction conditions, improves the purity and yield of the dye, but also significantly improves the performance of dye yellow 11.

The present invention relates to the field of optical imaging. More specifically, the present invention relates to a class of monoalkylated cyanine dyes having red to near-infrared (650-900 nm) emission, characterized by pH responsiveness, and to conjugates thereof with biological ligands. The present invention also relates to the use of these compounds as optical diagnostic agents in the imaging or therapy of solid tumors, to methods for their preparation and to compositions containing them. The monoalkylated cyanine dyes have the general formula (I), in which R1 and R3 are independently selected from the group consisting of hydrogen, -SO3H, -COOH and -CONH-Y; and R2 and R4 are hydrogen, or R1 together with R2 and R3 together with R4 both form two aryl rings optionally substituted by 1 to 4 -SO3H groups together with the atoms to which they are bonded; R5 is an alkyl group optionally substituted by a group selected from -SO3H, -COOH and -CONH2. #imgabs0#

The invention provides a fluorescent probe for detecting hydroxyl radicals as well as a preparation method and application thereof, and the preparation method comprises the following steps: (S10) synthesizing a first intermediate compound by taking 2, 3, 3-trimethyl-3H-indoline and methyl iodide as raw materials; (S20) synthesizing a second intermediate compound by taking phosphorus trichloride, cyclohexanone and anhydrous dimethylformamide as raw materials; (S30) mixing and reacting the first intermediate compound and the second intermediate compound to synthesize a compound IR780; and (S40) synthesizing OH-probe on the basis of the IR780. The prepared OH-probe has extremely high sensitivity and excellent selectivity on hydroxyl radicals, can be effectively used for monitoring and mapping the level of the hydroxyl radicals, and can be applied to detection of atherosclerosis, obesity, cancers, neurodegenerative diseases, inflammatory diseases and other free radical related diseases. Wide development prospects and practical application values are realized.

An optical film includes: a transparent substrate; and a colored layer laminated on at least one side of the transparent substrate, the colored layer containing a dye (A), the dye (A) containing a colorant having a wavelength of maximum absorption in the range of 470 nm to 530 nm, the colorant containing a dipyrromethene cobalt complex having a structure represented by formula (I), in which R1 to R7 are combined such that a free energy change between before and after the reaction, calculated by applying R1 to R7 in the formula (I) to a predetermined reaction formula (II) using a quantum chemical calculation program Gaussian 16 with a calculation method B3LYP and a basis function 6-31G (d,p) (however, a basis function LanL2DZ is assigned to elements having an atomic number greater than that of Kr in the periodic table), is 0.92 kcal / mol or greater.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing spirofluorene-isophorone bridging groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores containing spirofluorene-isophorone bridging groups in electro-optic devices (e.g., EOMs).

Disclosed herein are novel chromogenic conjugates, the conjugates comprising at least two detectable moieties.

A double fluorescent dye compound comprising a fluorescent dye A and a fluorescent dye B, wherein: - fluorescent dye A and fluorescent dye B are covalently linked; - the emission maxima of fluorescent dye A and fluorescent dye B are separated by at least 100 nm, measured at 23°C, pH 5.8; - fluorescent dye A is pH-sensitive and exhibits a maximum of 20% of the fluorescence intensity at pH 5 at pH 7.4; - the double fluorescent dye compound is lipophilic.

The invention discloses a reversible regulation coordination type rare earth nanocrystal-organic dye, which comprises a rare earth nanocrystal and a cyanine dye, the cyanine dye forms reversible coordination with the rare earth nanocrystal on the surface of the rare earth nanocrystal, the cyanine dye has a structure shown as a formula I: # imgabs0 #, and R is halogen or a group # imgabs1 # * represents a bonding position. The reversible regulation coordination type rare earth nanocrystal-organic dye can be subjected to reversible coordination, the structure of the organic dye is not damaged, continuous detection can be performed, the detection sensitivity is relatively high, and the anti-interference capability is strong. The invention also discloses a preparation method of the reversible regulation coordination type rare earth nanocrystal-organic dye, a luminescent probe, application of the luminescent probe in biological detection, and a method for detecting the pH value of gastric juice by using the luminescent probe.

The invention belongs to the technical field of near-infrared organic dye synthesis, and particularly discloses a cyanine dye with J aggregation characteristic, J aggregation nanoparticles, and preparation methods and applications of the cyanine dye and the J aggregation nanoparticles. The cyanine dye is 1-ethyl-2-(2-(2-(-3-(2-(1-ethyl-3, 3-dimethyl-1, 3-dihydro-2H-benzo [g] indole-2-subunit) ethylidene)-2-(2, 2, 2-trifluoro-N-(2-methylbenzyl) acetamide) cyclopent-1-ene-1-yl) vinyl)-3, 3-dimethyl-3H-benzo [g] indoleiodised salt, and the structural formula of the cyanine dye is shown in the description. The preparation method is simple, the J aggregation nanoparticles can be prepared by utilizing the unique property of J aggregation, the J aggregation nanoparticles have high light stability and have strong fluorescence emission in a near-infrared second region, and the material prepared by the invention can be used as a contrast agent and is applied to the field of near-infrared second region fluorescence imaging.

The present invention provides a photoelectric conversion element which has excellent sensitivity with respect to blue / green light, and an imaging element, an imaging element production method, an optical sensor, and a compound which relate to the photoelectric conversion element. A photoelectric conversion element according to the present invention comprises a photoelectric conversion element conductive film, a photoelectric conversion film, and a transparent conductive film in this order, wherein the photoelectric conversion film contains a compound represented by formula (1).

The present invention relates to an optical filter which is provided with a base material and a dielectric multilayer film that is superposed, as an outermost layer, on at least one main surface of the base material, wherein: the base material comprises a resin film that contains a resin and a near-infrared absorbing dye (A); and the dye (A) satisfies a specific spectral characteristic in the spectral transmittance curve of a coating film that is obtained by applying the dye (A), which has been dissolved in the resin, onto an alkali glass plate.

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

The invention discloses a para-substituted heptamethine quinone cyanine dye as well as a synthesis method and application thereof, the structural general formula of the para-substituted heptamethine quinone cyanine dye is shown as I, that is, by introducing a specific quinone structure and a substituent group, the near-infrared light absorption and triplet excited state generation capability is optimized. The dye efficiently absorbs light within the wavelength range of 600-700 nanometers, the intersystem crossing efficiency is remarkably improved, and the photo-initiation effect is enhanced. According to the dye, heavy atoms are not used, and the solubility and the environmental protection property are improved. The synthesis method is simple, low in cost, mild in condition and suitable for large-scale production. The key steps comprise formation of quaternary ammonium salt, preparation of a condensing agent and synthesis of a final product, and parameters of each step are optimized to ensure high yield. The dye is suitable for photodynamic therapy, photoinitiation of photopolymerization materials, biological imaging and the like, and has a wide application prospect.

In accordance with at least one aspect of this disclosure, there is provided an imaging agent, a including dye compound conjugated to an antigen specific targeting vector which can be particularly advantageous because their behavior in vivo can contribute to superior optical imaging properties, for example, by significantly increasing the solubility of the dye and / or targeting vector, increasing the target-to-background ratio of imaged tissues, leading to higher resolution imaging, and ultimately providing for better recognition of malignant tissue for resection and margin assessment and improved visualization during minimal invasive laparoscopic surgery, for example. A method of imaging tumor cells in a subject, can include, administering an imaging effective amount of an imaging agent according at least one embodiment of the invention; irradiating a region in the subject in which tumor cells are expected to be found with at a wavelength absorbed by the imaging agent; and detecting a signal from the imaging agent.

The invention relates to a near-infrared small-molecule fluorescent dye with a pentadecamethine conjugated chain and a preparation method and application thereof, the near-infrared small-molecule fluorescent dye has a structure as shown in a general formula A, and is a novel dye matrix based on two benzoindole structures connected by a pentadecamethine chain, the functional dye molecule with the absorption and emission peak wavelength in the near-infrared region is obtained through regulation and control of substituent groups on a parent structure, and different substituent groups can be introduced to a fifteen-membered methine chain and an indole N atom. The absorption and emission wavelength is in a near-infrared region of 1100-1300nm, and the material has the characteristics of high brightness, excellent light stability, low cytotoxicity, simplicity and convenience in synthesis, easiness in structure modification and the like. After water-soluble modification, the polymer can be widely applied to the biomedical fields of tumor targeting imaging, living body angiography and the like. General formula A # imgabs0 #

The invention relates to a fluorescent whitening agent, in particular to a stilbene biphenyl fluorescent whitening agent and a preparation method thereof. The stilbene biphenyl fluorescent whitening agent is a crystal represented by a formula (1), and contains crystal water or an isomer. The fluorescent whitening agent CBS provided by the invention comprises rod-shaped, needle-shaped and lamellar crystal forms. In the invention, all crystal forms are measured by adopting an X-ray diffractometer, and the water content is precisely measured by adopting a KarlFischer titration method. The X-ray scanning spectrum peak attributions of the crystal samples obtained by different preparation methods have significant difference. # imgabs0 #

Electrically neutral complex compounds of formula I including any stereoisomer or E / Z isomer thereof wherein: M is Fe < 2 + >, Ru < 2 + >, Os < 2 + >, Co < 3 + >, Rh < 2 + >, Rh < 3 + >, Ir < 3 + >, Ni < 2 + >, Pd < 2 + >, Pt < 2 + > or Pt < 4 + >, in particular Ru < 2 + >; t and T'are H or (C1-C3)-alkyl; lig is a bidentate ligand, in particular 2, 2 '-dipyridyl (bpy) or 4, 7-diphenyl-1, 10-phenanthroline (BPhen); and A is an anion from a pharmaceutically acceptable acid, the electrically neutral complex compounds of formula I are useful in human therapy, in particular as photosensitizers (PS) in photodynamic therapy (PDT) of cancer, skin diseases, fungal infections or microbial infections. They are almost non-toxic under dark conditions at therapeutic doses and exhibit good to excellent photoactivity under hypoxic conditions. They can be used for PDT treatment of deep hypoxia tumors by using light within a far-infrared to near-infrared light treatment window.

A cat litter comprising an absorbent and at least one fluorescent compound wherein the at least one fluorescent compound does not include cat urine wherein the at least one fluorescent compound attracts a cat to excrete in the cat litter. The cat litter comprises a solid particulate material coated with a cellulose solution comprising at least one fluorescent material.

The invention discloses a preparation method of a near-infrared two-region fluorescently-labeled phospholipid molecule and a preparation method of a lipid nano-carrier of the phospholipid molecule, and relates to the field of preparation methods of cyanine dyes. The invention aims to solve the technical problems that the application of the organic cyanine dye in a living body is limited by the hydrophobicity of the organic cyanine dye and the fluorescence intensity is low due to the aggregation quenching effect of the organic cyanine dye. The method comprises the following steps: preparing a compound 2 from 1, 8-naphthalimide and iodohexane, and then preparing C6 from the compound 2, 2-chloro-3-(hydroxymethylene)-1-cyclohexene-1-formaldehyde and sodium acetate; then C6 and mercaptobenzoic acid are used for preparing C6-COOH; the preparation method comprises the following steps: preparing C6-Lipid from N, N-diisopropylethylamine, HBTU, C6-COOH and 4-(1, 2, 2-triphenylvinyl) aniline by virtue of a hydrothermal method; the preparation method comprises the following steps: preparing a lipid nano-carrier from C6-Lipid, DMPC (Dimethyl Pyrrolidone), DOPE (Dioctyl Olefin Polyethylene) and According to the phospholipid molecule and the lipid nano-carrier thereof prepared by the invention, effective imaging of fluorophores is realized, and aggregates such as J aggregation and the like are possibly generated, so that the fluorescence quantum yield is improved, and an efficient fluorescence imaging effect is achieved. The cyanine dye prepared by the invention is used for fluorescence imaging.

The invention is applicable to the technical field of near-infrared imaging probes, and provides a near-infrared two-region albumin efficient in-situ targeting cyanine dye as well as a preparation method and application thereof. The structural formula of the cyanine dye is # imgabs 0 #, R structure is I or II: # imgabs 1 #, and n is any one of 2-10. The cyanine dye provided by the invention can quickly form stable covalent binding with albumin in situ in an in-vitro or in-vivo physiological environment so as to generate bionic fluorescent protein with bright luminescence and high biocompatibility. The in-situ bionic fluorescent protein construction strategy provided by the invention not only can realize high-resolution mouse angiography, but also can realize real-time and accurate monitoring on blood-brain barrier damage accompanying cerebral ischemic stroke of the mouse. The dye provided by the invention can realize multi-channel joint monitoring with angiographic contrast agents with different excitation wavelengths, and realizes simultaneous marking of cerebral vascular and brain injury after cerebral apoplexy.

Provided herein are methods for multiplexed in situ analysis of biomolecules in a tissue. In particular, provided herein are methods for multiplexed single-cell in situ protein and nucleic acid profiling in fixed or fresh tissues, that allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal.

The invention belongs to the technical field of biochemistry, and relates to a fluorescence / photoacoustic bimodal probe responding to Cu (I) and a preparation method and application thereof. The fluorescence / photoacoustic bimodal probe responding to Cu (I) has high selectivity and sensitivity, has efficient tumor targeting ability, can be used for dynamic tracing of Cu (I) in tumor, can dynamically image Cu (I) in tumor by combining with a three-dimensional photoacoustic / living body fluorescence imaging technology and the probe HCyCu1, provides a new detection means for detection of Cu (I), and has wide application prospects. And a potential tool is provided for tumor diagnosis. According to the preparation method of the bimodal probe, the adopted raw materials are easy to obtain, the reaction conditions are mild and easy to control, the reaction cost is saved, and the yield of a target product is guaranteed. The structural formula of the probe is as follows: # imgabs0 #.

The present disclosure relates to novel photoluminescent complexes comprising a BODIPY moiety covalently attached to a blue light absorbing xanthenoisoquinoline derivative, color conversion films comprising the photoluminescent complexes, and backlight units employing the same.

The invention discloses a multi-cyano offset substituted pentamethine cyanine dye and a synthesis method and application thereof, and the dye has the following general formula structure: # imgabs0. According to the multi-cyano offset substituted pentamethine cyanine dye disclosed by the invention, the absorption emission wavelength is increased by introducing an offset substitution structure; the dye has near-infrared first-area imaging and treatment performance, so that the optimal excitation and emission wavelength can be flexibly selected, the dye shows obvious Stokes shift, reduction of self-absorption and scattering effects is facilitated, the imaging definition and depth are improved, the molar extinction coefficient of the prepared dye is up to 190000, and the dye can be applied to near-infrared first-area imaging and treatment of the near-infrared first-area imaging and treatment of the near-infrared first-area imaging and treatment of the near-infrared first-area imaging. According to the present invention, with the application of the dye, the light energy utilization degree of the dye is substantially improved, the long wavelength light with the deeper penetration depth can be strongly absorbed, the light energy capture and conversion can be effectively achieved, the photosensitizer efficiency can be improved, the light dose can be reduced, the phototoxicity can be reduced, the high absolute fluorescence quantum yield can be represented, and the biological imaging effect can be substantially improved; and the imaging quality is higher.