518results about "Methine/polymethine dyes" patented technology

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

Electrically neutral complex compounds of formula I including any stereoisomer or E / Z isomer thereof wherein: M is Fe < 2 + >, Ru < 2 + >, Os < 2 + >, Co < 3 + >, Rh < 2 + >, Rh < 3 + >, Ir < 3 + >, Ni < 2 + >, Pd < 2 + >, Pt < 2 + > or Pt < 4 + >, in particular Ru < 2 + >; t and T'are H or (C1-C3)-alkyl; lig is a bidentate ligand, in particular 2, 2 '-dipyridyl (bpy) or 4, 7-diphenyl-1, 10-phenanthroline (BPhen); and A is an anion from a pharmaceutically acceptable acid, the electrically neutral complex compounds of formula I are useful in human therapy, in particular as photosensitizers (PS) in photodynamic therapy (PDT) of cancer, skin diseases, fungal infections or microbial infections. They are almost non-toxic under dark conditions at therapeutic doses and exhibit good to excellent photoactivity under hypoxic conditions. They can be used for PDT treatment of deep hypoxia tumors by using light within a far-infrared to near-infrared light treatment window.

The invention discloses a triarylmethane type I photosensitive dye as well as a synthesis method and application thereof. The structure of the dye is shown as a general formula I; intramolecular charge separation is optimized by regulating substituent groups, and the generation efficiency of superoxide anions and hydroxyl radicals is remarkably improved. According to the synthesis method, 4-diphenylaminobenzaldehyde or 4-vinyl benzaldehyde is used as a raw material, efficient preparation is achieved through the steps of condensation, oxidation and the like, the raw material is easy to obtain, and operation is easy and convenient. The dye has strong absorption at the wavelength of 600-630 nm, is suitable for red light triggered photodynamic therapy (PDT), especially keeps high reactive oxygen yield under the hypoxic condition, and breaks through the oxygen dependence limitation of traditional PDT. Experiments show that the dye can induce ferroptosis of tumor cells, has the functions of fluorescence imaging and treatment, and has wide application prospects in the fields of antitumor drugs, in-vivo fluorescence labeling, photoresponsive functional preparations and the like.

The invention discloses a preparation method and application of near-infrared fluorescent dye DOM-O for acute alcoholic liver injury detection. The specific chemical structural formula of the near-infrared fluorescent dye DOM-O is shown in the specification. The near-infrared fluorescent dye prepared by the invention has excellent fluorescence imaging performance, can realize specific fluorescence imaging diagnosis of the acute alcoholic liver injury, and provides an imaging dye with application prospect for early detection and clinical diagnosis of the acute alcoholic liver injury.

The present invention relates to precursors of dibenzoylmethane compounds having an amide group on one of the rings, and corresponding photoconversion compounds, pharmaceutically or cosmetically acceptable salts thereof, or stereoisomers or mixtures thereof, for use in protecting human or animal living organisms or materials from ultraviolet light. The present invention also relates to the preparation processes thereof, as well as cosmetic compositions, pharmaceutical compositions or personal care compositions thereof.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

A wavelength selective absorption filter contains a resin, a coloring agent, and a compound having at least one polar group of a carboxylic acid ester bond, a carboxylic acid amide bond, a sulfonic acid amide bond, a urethane bond, or a sulfonyl bond and a MW≤1,000 where dye includes at least one of dye A having a main absorption wavelength range at a wavelength of 390 to 440 nm and dye D having a main absorption wavelength range at a wavelength of 680 to 780 nm, a 20% value wavelength A with respect to an absorbance maximal value exhibited by a main absorption wavelength is 455 nm or less where dye A is contained, and a 20% value wavelength D with respect to the absorbance maximal value exhibited by the main absorption wavelength is 640 nm or more where dye D is contained, and a display device.

A heptamethine cyanine near-infrared fluorescent dye as well as a preparation method and use thereof are provided, and relate to the technical field of organic fluorescent molecules. The heptamethine cyanine near-infrared fluorescent dye has a structure represented by formula I. The heptamethine cyanine near-infrared fluorescent dye provided in the present disclosure has better in-vivo metabolic characteristics, no accumulation in normal tissues such as liver and long tumor tissue developing window time, is more suitable for precise diagnosis of tumors, possesses a certain clinical application prospect, and can be applied to fluorography of clinical tumors and the like.

This invention relates to compounds and methods for treating cancer. In various embodiments, the compound includes a heptamethine carbocyanine dye (HMCD) component, a camptothecin derivative component, and a linker moiety (L) connecting the HMCD component and the camptothecin derivative component. In various embodiments, the method includes administering a therapeutically effective amount of the compound to a subject, thereby contacting a tissue of the subject with the compound such that the compound binds to the tissue; detecting the compound bound to the tissue, wherein the presence of the compound bound to the tissue is indicative of the cancer in the subject; and delivering the compound to the tissue thereby treating the cancer in the subject.

The present disclosure relates to a novel fluorogenic dimer compound, useful as a probe for detection of endogenous receptors, in particular G protein-coupled receptors. The present invention provides compositions and kits comprising such compound and methods of labeling a biomolecule, comprising the step of contacting the biomolecule with the compound of the invention.

The invention belongs to the field of biosensing and fluorescence imaging, and particularly relates to a fluorescent probe compound and application thereof. The probe compound is a compound as shown in a formula I or a compound as shown in a formula II, or a pharmaceutically acceptable salt thereof; the structures of the compound in the formula I and the compound in the formula II are shown in the specification, and the definition of each group is shown in any embodiment of the invention. The fluorescent probe compound shows rapid and high reactivity to oxidizing free radicals, the generated fluorescent compound is high in fluorescence intensity and good in stability, and early diagnosis can be carried out on ferroptosis-related disease models such as oxygen-glucose deprivation / reperfusion and drug liver injury on living cell or living body levels and the like. I II

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing furanyl accepting groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups (e.g., methods of drying and / or poling, and the like), (3) uses of NLO chromophores containing furanyl accepting groups in electro-optic devices (e.g., EOMs).

The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

The present application relates to the technical field of fluorescent dyes, in particular to an asymmetric pentamethine cyanine compound. The compound comprises a structure as shown in formula I. The compound provided by the present application has good water solubility, near-infrared absorption, high fluorescence quantum yield and good molar absorption coefficient, and can be used in nucleic acid labeling, DNA sequencing, cell imaging, protein labeling or specific recognition of amino acids.

The present application relates to an optical filter having a substrate and a dielectric multilayer film laminated on at least one main surface side of the substrate and serving as an outermost layer, wherein the substrate has a resin film containing a pigment (U) having a maximum absorption wavelength in the range of 360 nm to 395 nm in dichloromethane, a pigment (A) having a maximum absorption wavelength in the range of 600 nm to 800 nm in dichloromethane, and a resin, and the optical filter satisfies specific spectral characteristics.

The present invention relates to an unsymmetrical squaraine dye of formula (I) and process for the preparation thereof. The process includes dissolving a 3-cycloalkene-1,2-dione compound in acetone and aqueous HCl to afford a semisquaraine compound. The process includes refluxing the semisquaraine compound and phenyl carboxylic acid dissolved in solvent to afford the unsymmetrical squaraine dye. Further, the present invention relates to an electronic device with an enhanced device efficiency containing a dye of formula (I) co-sensitized with a squaraine dye.

The present disclosure relates to a phosphor compound for diagnosing fire blight in fruit trees based on fluorescence and use thereof. The compound is capable of selectively detecting Erwinia amylovora, the causal pathogen of fire blight in fruit trees, and emits red fluorescence in response. Due to its rapid diagnostic response and high sensitivity, the compound can be effectively used for diagnosing fire blight in fruit trees through various simple methods such as spraying or swabbing, without the need for specialized equipment.

An object of the present invention is to provide a luminescent particle having an emission maximum wavelength in a long wavelength range of 680 nm or longer and exhibiting a high quantum yield; and a compound having an emission maximum wavelength in a long wavelength range of 680 nm or longer and exhibiting a high quantum yield in the particles. According to the present invention, provided is a luminescent particle containing at least one kind of compound represented by Formula (1) (definitions of substituents in the formula are as set forth in the description) and a particle.

To provide a polypropylene colored resin composition that excels in color development, washing resistance, and sublimation resistance and can be stably supplied.SOLUTION: A polypropylene colored resin composition contains a polypropylene resin and a colorant, the colorant including a compound of a predetermined structure.SELECTED DRAWING: None

To provide an ultraviolet absorbing composition, a molding and a coated film which have heat resistance, light resistance and transparency in addition to such blue light cutting property as to absorb ultraviolet light and light in a blue light region at a wavelength about 400 nm.SOLUTION: A composition has ultraviolet absorbing property, and contains a compound represented by the following general formulae (1) and (2). The composition is used for the application of a resin composition containing a resin, or a photosensitive resin composition containing a photopolymerizable compound and a photopolymerization initiator.SELECTED DRAWING: None

Disclosed is a compound having the following formula (1):as well as to the use of such as a dye sensitizer.Also disclosed is a dye sensitized solar cell including at least one compound of formula (I) as dye sensitizer.

The present invention addresses the first problem of providing a photoelectric conversion element having low electric field strength dependency of a response speed to blue-green light. Moreover, the present invention addresses the second problem of providing an imaging element, a method for manufacturing an imaging element, an optical sensor, and a compound.　This photoelectric conversion element has a conductive film, a photoelectric conversion film, and a transparent conductive film in this order, wherein the photoelectric conversion film contains a compound represented by formula (1-1) or formula (1-2).

This invention provides a series of cyanine-based near-infrared II fluorescent dye molecules with different side-group structures, exhibiting structures as shown in A-G. This invention uses the classic indocyanine green as the backbone framework, expanding the functionality and improving the hydrophilicity of the fluorescent small molecules by incorporating hydrophilic functional groups, enabling highly ordered assembly in aqueous solution. Notably, when the above-mentioned cyanine dyes are combined with FBS, the fluorescence intensity increases, exhibiting better photothermal effects, reducing liver and spleen accumulation, and enabling specific imaging of lymph nodes. During near-infrared II imaging, the influence of biological background signals is reduced, and the penetration depth is stronger, providing a novel technical means for the development of precision surgical navigation systems.

Crystalline forms of indocyanine green, methods for their preparation, pharmaceutical compositions containing same, and methods for their use as pharmaceuticals or diagnostic agents are provided. The present invention relates to a novel process for the preparation of indocyanine green, comprising the step of converting 4-[2-[7-[1,1-dimethyl-3-(4-sulfobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonic acid to indocyanine green by treatment with sodium chloride. The present invention also relates to crystalline forms of indocyanine green, pharmaceutical compositions containing same, and methods of their use as medicines or diagnostic agents.

To provide compounds of the cyanine family having near-infrared emission exhibiting improved physicochemical and biological properties, and to provide conjugates thereof with biological ligands.SOLUTION: Cyanine derivatives of Formula (I) are provided. It may be suitably conjugated to an appropriate targeting moiety via an appropriate functional group which acts as a site of attachment.SELECTED DRAWING: None

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores, including (2) compositions / materials / resistive layers comprising NLO chromophores, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores in electro-optic devices (e.g., electro-optic modulators (EOMs)). NLO chromophores disclosed herein not only have large EO effect, but also have fast modulation speed. In addition, NLO chromophores disclosed herein have superior refractive index, photostability and thermal stability compared to other EO Materials. As a consequence, NLO chromophores herein are particularly suited for use as EO materials in connection with low power and small footprint devices, including devices used in data acquisition systems, analog I / O modules, field transmitters, lab and field instrumentation, servo drive control modules, direct current (DC) power supply, alternating current (AC), and / or electronic load.

The application discloses a kind of two-photon fluorescent probe for detecting industrial hydrogen sulfide or sodium sulfide and a preparation method thereof, and relates to the technical field of fluorescent probe.The application designs and synthesizes a compound with D-Π-A structure, which can be used as a two-photon fluorescent probe to selectively detect H2S, and is suitable for detecting H2S or Na2S residue in industry, with high sensitivity and good specificity.The reaction product of the compound and H2S can be used as an organic fluorescent dye.