306results about "Methine/polymethine dyes" patented technology

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The present invention relates to precursors of dibenzoylmethane compounds having an amide group on one of the rings, and corresponding photoconversion compounds, pharmaceutically or cosmetically acceptable salts thereof, or stereoisomers or mixtures thereof, for use in protecting human or animal living organisms or materials from ultraviolet light. The present invention also relates to the preparation processes thereof, as well as cosmetic compositions, pharmaceutical compositions or personal care compositions thereof.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

A wavelength selective absorption filter contains a resin, a coloring agent, and a compound having at least one polar group of a carboxylic acid ester bond, a carboxylic acid amide bond, a sulfonic acid amide bond, a urethane bond, or a sulfonyl bond and a MW≤1,000 where dye includes at least one of dye A having a main absorption wavelength range at a wavelength of 390 to 440 nm and dye D having a main absorption wavelength range at a wavelength of 680 to 780 nm, a 20% value wavelength A with respect to an absorbance maximal value exhibited by a main absorption wavelength is 455 nm or less where dye A is contained, and a 20% value wavelength D with respect to the absorbance maximal value exhibited by the main absorption wavelength is 640 nm or more where dye D is contained, and a display device.

The present disclosure relates to a novel fluorogenic dimer compound, useful as a probe for detection of endogenous receptors, in particular G protein-coupled receptors. The present invention provides compositions and kits comprising such compound and methods of labeling a biomolecule, comprising the step of contacting the biomolecule with the compound of the invention.

The invention belongs to the field of biosensing and fluorescence imaging, and particularly relates to a fluorescent probe compound and application thereof. The probe compound is a compound as shown in a formula I or a compound as shown in a formula II, or a pharmaceutically acceptable salt thereof; the structures of the compound in the formula I and the compound in the formula II are shown in the specification, and the definition of each group is shown in any embodiment of the invention. The fluorescent probe compound shows rapid and high reactivity to oxidizing free radicals, the generated fluorescent compound is high in fluorescence intensity and good in stability, and early diagnosis can be carried out on ferroptosis-related disease models such as oxygen-glucose deprivation / reperfusion and drug liver injury on living cell or living body levels and the like. I II

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing furanyl accepting groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups (e.g., methods of drying and / or poling, and the like), (3) uses of NLO chromophores containing furanyl accepting groups in electro-optic devices (e.g., EOMs).

The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

The present application relates to the technical field of fluorescent dyes, in particular to an asymmetric pentamethine cyanine compound. The compound comprises a structure as shown in formula I. The compound provided by the present application has good water solubility, near-infrared absorption, high fluorescence quantum yield and good molar absorption coefficient, and can be used in nucleic acid labeling, DNA sequencing, cell imaging, protein labeling or specific recognition of amino acids.

The present application relates to an optical filter having a substrate and a dielectric multilayer film laminated on at least one main surface side of the substrate and serving as an outermost layer, wherein the substrate has a resin film containing a pigment (U) having a maximum absorption wavelength in the range of 360 nm to 395 nm in dichloromethane, a pigment (A) having a maximum absorption wavelength in the range of 600 nm to 800 nm in dichloromethane, and a resin, and the optical filter satisfies specific spectral characteristics.

The present invention relates to an unsymmetrical squaraine dye of formula (I) and process for the preparation thereof. The process includes dissolving a 3-cycloalkene-1,2-dione compound in acetone and aqueous HCl to afford a semisquaraine compound. The process includes refluxing the semisquaraine compound and phenyl carboxylic acid dissolved in solvent to afford the unsymmetrical squaraine dye. Further, the present invention relates to an electronic device with an enhanced device efficiency containing a dye of formula (I) co-sensitized with a squaraine dye.

The present disclosure relates to a phosphor compound for diagnosing fire blight in fruit trees based on fluorescence and use thereof. The compound is capable of selectively detecting Erwinia amylovora, the causal pathogen of fire blight in fruit trees, and emits red fluorescence in response. Due to its rapid diagnostic response and high sensitivity, the compound can be effectively used for diagnosing fire blight in fruit trees through various simple methods such as spraying or swabbing, without the need for specialized equipment.

An object of the present invention is to provide a luminescent particle having an emission maximum wavelength in a long wavelength range of 680 nm or longer and exhibiting a high quantum yield; and a compound having an emission maximum wavelength in a long wavelength range of 680 nm or longer and exhibiting a high quantum yield in the particles. According to the present invention, provided is a luminescent particle containing at least one kind of compound represented by Formula (1) (definitions of substituents in the formula are as set forth in the description) and a particle.

To provide a polypropylene colored resin composition that excels in color development, washing resistance, and sublimation resistance and can be stably supplied.SOLUTION: A polypropylene colored resin composition contains a polypropylene resin and a colorant, the colorant including a compound of a predetermined structure.SELECTED DRAWING: None

The present invention addresses the first problem of providing a photoelectric conversion element having low electric field strength dependency of a response speed to blue-green light. Moreover, the present invention addresses the second problem of providing an imaging element, a method for manufacturing an imaging element, an optical sensor, and a compound.　This photoelectric conversion element has a conductive film, a photoelectric conversion film, and a transparent conductive film in this order, wherein the photoelectric conversion film contains a compound represented by formula (1-1) or formula (1-2).

This invention provides a series of cyanine-based near-infrared II fluorescent dye molecules with different side-group structures, exhibiting structures as shown in A-G. This invention uses the classic indocyanine green as the backbone framework, expanding the functionality and improving the hydrophilicity of the fluorescent small molecules by incorporating hydrophilic functional groups, enabling highly ordered assembly in aqueous solution. Notably, when the above-mentioned cyanine dyes are combined with FBS, the fluorescence intensity increases, exhibiting better photothermal effects, reducing liver and spleen accumulation, and enabling specific imaging of lymph nodes. During near-infrared II imaging, the influence of biological background signals is reduced, and the penetration depth is stronger, providing a novel technical means for the development of precision surgical navigation systems.

Crystalline forms of indocyanine green, methods for their preparation, pharmaceutical compositions containing same, and methods for their use as pharmaceuticals or diagnostic agents are provided. The present invention relates to a novel process for the preparation of indocyanine green, comprising the step of converting 4-[2-[7-[1,1-dimethyl-3-(4-sulfobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonic acid to indocyanine green by treatment with sodium chloride. The present invention also relates to crystalline forms of indocyanine green, pharmaceutical compositions containing same, and methods of their use as medicines or diagnostic agents.

To provide compounds of the cyanine family having near-infrared emission exhibiting improved physicochemical and biological properties, and to provide conjugates thereof with biological ligands.SOLUTION: Cyanine derivatives of Formula (I) are provided. It may be suitably conjugated to an appropriate targeting moiety via an appropriate functional group which acts as a site of attachment.SELECTED DRAWING: None

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores, including (2) compositions / materials / resistive layers comprising NLO chromophores, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores in electro-optic devices (e.g., electro-optic modulators (EOMs)). NLO chromophores disclosed herein not only have large EO effect, but also have fast modulation speed. In addition, NLO chromophores disclosed herein have superior refractive index, photostability and thermal stability compared to other EO Materials. As a consequence, NLO chromophores herein are particularly suited for use as EO materials in connection with low power and small footprint devices, including devices used in data acquisition systems, analog I / O modules, field transmitters, lab and field instrumentation, servo drive control modules, direct current (DC) power supply, alternating current (AC), and / or electronic load.

The present invention provides a pigment composition that can improve absorbance across the entire visible light spectrum without increasing absorbance in the ultraviolet region. Furthermore, it provides a colored composition and molded article that achieve high light-shielding properties without interfering with active energy ray curing. [Solution] The pigment composition of the present invention comprises one or more compounds (A) represented by the following general formula (i), and a pigment (B). The pigment composition comprises one or more pigments selected from the group consisting of carbon black, benzodifuranone pigments, and perylene pigments. [C1] TIFF2026095407000040.tif17170

To provide an infrared cut filter, a filter for a solid-state imaging element, a solid-state imaging element, and a method for manufacturing the filter for the solid-state imaging element in which heat resistance and resistance to a stripping liquid can be improved.SOLUTION: A solid-state imaging element 10 includes an infrared cut filter 13 and a photoelectric conversion element 11, the infrared cut filter 13 including polymethine, cations located one by one on both terminals of the polymethine and having two heterocyclic rings including nitrogen, a cyanine pigment including tris (pentafluoroethyl) trifluoro-phosphoric acid, and a copolymer. The copolymer is represented by the following formula (1) and includes a first repeating unit derived from an acryl monomer including a circular ester group and a second repeating unit derived from a monomer including a functional group which reacts with the circular ester group.SELECTED DRAWING: Figure 1

A composition comprising a resin (A) and a compound (B) which comprises a cation and an anion having a partial structure represented by formula (I). [In formula (I), ring W1 represents an optionally substituted ring structure, and ring W2 represents a ring structure having at least one double bond as a constituent requirement for the ring and ring W2 may have a substituent.] The rings W1 and W2 have formed a fused ring, and the fused ring formed from the rings W1 and W2 is preferably a ring having no aromaticity.

The invention relates to a compound as shown in a formula (I) and / or a formula (II) and / or a formula (III) or a tautomer or pharmaceutically acceptable salt thereof, a preparation method and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicine. Specifically, the fluorescent probe can be used as a fluorescent probe for cytological imaging, can also be used as a near-infrared fluorescent imaging probe for diagnosing benign / malignant lesions such as fibrosis, nodules and tumors, and can also be applied to research of related biological events in cytobiology and molecular biology. The fluorescent probe can be particularly applied to fluorescent navigation in tumor resection surgery.

Design and applications of a class of water-soluble small molecules represented by formula 1. The molecules, in their dilute aqueous solutions, exhibit lower critical solution temperature (LCST) phase transitions near room temperature, inducing a temperature triggered switching of opacity. Further, disclosed is a scalable smart window, akin to a radiative energy management system, that can be incorporated into the built environment for imparting energy efficiency. The window fabrication is facile wherein the aqueous solution is sandwiched between two transparent glass panes to enable modulation of light and heat transmission. The dynamic window of present invention represents with multifarious applications in developing scalable, smart energy management systems for indoor building environments is envisioned to be a major contribution towards cost effective smart glass technologies.

The invention discloses an electron-rich BODIPY type I photosensitive dye as well as a preparation method and application thereof. The photosensitive dye has a structure as shown in a general formula I. The BODIPY photosensitive dye compound with the I-type photodynamic performance disclosed by the invention has relatively strong near-infrared region absorption and electron transfer capabilities, and superoxide anions can be efficiently generated. Under the excitation of near-infrared light, the photodynamic killing can be carried out on normal oxygen and hypoxic cancer cells. Meanwhile, the electron-rich type BODIPY type I photosensitive dye has a good application prospect in the aspect of treating solid tumors in a living body.

The present invention provides compounds that are useful as modulators of the cannabinoid receptor 2 (CB2R) having the general formula (I), wherein R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Described herein are compositions relating to cell-penetrating conjugates of formula (I) or (IV). The compositions are capable of penetrating cells and recognizing intracellular targets (e.g., STAT3) and are, inter alia, useful for diagnostic and therapeutic purposes.

The present invention provides an optical member for use in a display device having a specific light-emitting part, the optical member including a specific light-bending part and a light-absorbing part which has an absorption waveform selected from specific absorption waveforms A to D and which also has the absorption waveform B or C. The present invention also provides a display device including the same.　Absorption waveform B: a specific absorption waveform in which two wavelengths giving half the absorbance of an absorption maximum exist in the wavelength region exceeding λBMax and less than λGMax Absorption waveform C: a specific absorption waveform in which two wavelengths giving half the absorbance of an absorption maximum exist in the wavelength region exceeding λGMax and less than λRMax Additionally, the units of wavelength are all nm in the above formulas (1) and (2).　λBMax: maximum emission wavelength exhibited by blue light emission by display device λGMax: maximum emission wavelength exhibited by green light emission by display device λRMax: maximum emission wavelength exhibited by red light emission by display device

The invention relates to a nitroimidazole group meso-substituted heptamethine cyanine dye as well as a preparation method and application thereof. According to the dye, a nitroimidazole group is introduced into the middle position of a heptamethine cyanine parent nucleus, so that the dye has excellent absorption characteristics in a near-infrared region, the excitation wavelength is 730-780 nm, the emission wavelength is 800-860 nm, and the dye has good tissue penetrating power. The nitroimidazole group can effectively quench fluorescence in an excited state through a light-induced electron transfer effect, energy is promoted to be released in a non-radiative transition mode, the photothermal conversion efficiency is remarkably improved, and meanwhile high light stability and low fluorescence quantum yield are kept. The dye can be further prepared into a nano preparation and shows excellent biocompatibility and tumor targeting ability. The compound has wide application prospects in the fields of non-diagnostic or therapeutic protein labeling, bioimaging, photothermal therapy and the like, is especially suitable for preparing efficient photosensitive reagent drugs for tumor photothermal therapy, and provides a new strategy for design of near-infrared photothermal diagnosis and treatment materials.

The disclosure relates to a benzopyrylium dye of the formula (I),in which R200, R201, R202, R203, R204, R205, R206, R207 and R208 independently of one another are each hydrogen, C1 to C16 alkyl, C4 to C7 cycloalkyl, C7 to C16 aralkyl, C6 to C10 (het)aryl, hydroxyl, C1 to C6 alkoxy, or dialkylamino, the dialkylamino being selected from the group consisting of diethylamino, dimethylamino, diisopropylamino, a six-membered saturated ring attached via the N of the amino group, which may additionally contain an N or O and may be substituted by nonionic arbitrary radicals, or a combination of at least two thereof, and / or R200 with R201 or R201 with R202 or R202 with R203 and / or R205 with R206 and / or R206 with R207 each independently of one another form a —CH═CH—CH═CH— bridge, and A is a —CH2— or a —CH2—CH2— bridge, where the anion Ann− has a molecular weight of ≥200 g / mol and does not contain a halogen atom.