45 results about "Semicarbazide" patented technology

The invention discloses a preparation method of a high-purity ultra-clean hydroxylamine aqueous solution. A four-stage purification process comprises the following steps: 1) low-temperature chelation-ceramic membrane metal removal; 2) molecular sieve membrane rectification decomposition prevention; 3) pulse electrodialysis reversal deep desalination; and 4) gradient filtration terminal refining. According to the preparation method of the high-purity ultra-clean hydroxylamine aqueous solution, a low-temperature molecular sieve membrane rectification technology is adopted, hydroxylamine liquid-phase thermal decomposition is avoided through a vapor phase separation mechanism, and the decomposition rate is reduced to 1t from 15% of a traditional process; the method comprises the following steps of: removing metal through chelation-electrodialysis synergistically, ensuring that Fe and Cu ion residues are less than or equal to 0.05 ppb through a thiosemicarbazide-bipolar membrane system, ensuring the nitrogen environment in the whole process, ensuring that the dissolved oxygen is less than or equal to 5ppb, replacing liquid phase distillation with molecular sieve membrane vapor phase separation, solving hydroxylamine liquid phase thermal decomposition, and breaking through the trace metal removal limit by combining thiosemicarbazide-bipolar membrane synergistically removing impurities. And then through nanoscale terminal filtration, the metal / particle control reaches ppb-level limit which is superior to the SEMI standard, and double spanning of quality and cost is realized.

The present invention relates to the field of the preparation of polyurethane elastic fibers, and relates to a preparation method for a bio-based polyurethane elastic fiber, comprising: preparing polyether polyol from sucrose, glycerol, dimethylamine and propylene oxide; adding a solvent, i.e., N,N-dimethylacetamide, and polyether polyol and polyisocyanate into a reaction tank, and adding p-Toluenesulfonyl semicarbazide and aluminum methylenebis(2,4-di-tert-butylphenoxy) phosphate to prepare a spinning solution; and subjecting the spinning solution to spinning and oil application by means of dry spinning technology to obtain the bio-based polyurethane elastic fiber. The present invention ensures that the properties of polyurethane elastic fibers do not deteriorate or are partially enhanced, while the cost and performance advantages are achieved.

The present invention relates to the technical field of multiphase catalysts, and specifically relates to a carbon-based Cu-Ni dual-atom cluster catalyst, a preparation method thereof, and an application thereof. The preparation method includes the following steps: mixing an aqueous solution of thiosemicarbazide, magnesium chloride hexahydrate, an alkali, a nickel salt, a copper salt, and a saccharide compound, and performing freeze-drying to obtain a precursor; sequentially performing preheating treatment, first pyrolysis, and second pyrolysis on the precursor to obtain a carbon-based Cu-Ni dual-atom catalyst; formulating the carbon-based Cu-Ni dual-atom catalyst into a slurry, adhering it to a current collector, and performing in-situ electrolysis treatment to obtain a carbon-based Cu-Ni dual-atom cluster catalyst. The preparation method of the present invention can not only precisely control the number of metal atoms in the metal atom cluster, but also realize the reconstruction of Cu-Ni dual-atom sites, overcoming the problems that it is difficult to control the size of metal particles and it is difficult to exert the advantages of atomic-level catalysts in the traditional high-temperature carbonization method.

The invention provides a composition for inhibiting tumor growth and a preparation method thereof, and belongs to the technical field of medicines. After selenium is loaded, folic acid is coupled, and folic acid-selenium polysaccharide nanoparticles are prepared; notoginsenoside, curcumin, alizarin and hairyvein agrimony phenolic acid are embedded in pH-sensitive lipidosome, and the pH-sensitive lipidosome is uniformly mixed with folic acid-selenium polysaccharide nanoparticles and semicarbazone compounds to prepare the composition for inhibiting tumor growth. The composition for inhibiting tumor growth prepared by the invention has a relatively good anti-tumor effect, can release active components in a targeted manner at a tumor part, can reverse drug resistance, reduce the dosage of chemical drugs, reduce toxicity and improve patient compliance, is high in bioavailability, and has a wide application prospect.

The present application belongs to the technical field of water treatment, and relates to a heat-sensitive color developing agent F-103 production wastewater treatment method. The present application performs multistage treatment on the wastewater. First, an alkaline chemical separation reaction is performed on the wastewater to remove part of the acidic polar organic matter 3-p-tolylsulfonylureido phenol, p-toluenesulfonic acid and the like in the water. Then, an acid chemical separation reaction is performed to further remove the alkaline polar organic matter intermediate MAPOTs and the like in the water. Subsequently, an adsorption reaction is performed using activated carbon to further remove the organic matter and inorganic impurities in the water. Finally, evaporation and concentration are performed to recover the salt sodium chloride. The wastewater treatment of the present application recovers the salt sodium chloride in the wastewater as a resource under the premise of solving the toxicity problem of the organic matter in the wastewater, and realizes the harmless treatment and the reduction of hazardous waste of the wastewater.

The invention relates to a trifluoro-uracil compound containing a semicarbazide structure and a preparation method and application thereof, and provides the trifluoro-uracil compound containing the semicarbazide structure, and the structure is shown as a formula I; the compound has excellent herbicidal toxicological properties, can be used as a pesticide, and particularly can be used as an active ingredient of a herbicide; when being applied to pesticides, the compound has a wider weed control spectrum, can generate a better killing or preventing and treating effect on various weeds, and shows excellent herbicidal activity; the compound is simple in structure, raw materials are easy to obtain and low in cost, and the compound has higher industrial value.

The invention relates to the technical field of organic polymer auxiliaries, and particularly discloses a fluorine-containing release agent with self-healing performance and a preparation method and application thereof. The release agent is prepared from the following components in parts by weight: 1.0 to 10.0 parts of self-healing fluorine modified organic silicon resin, 0.1 to 2.5 parts of simethicone, 0.001 to 0.05 part of stabilizer and 86.0 to 99.0 parts of organic solvent, the self-healing fluorine modified organic silicon resin is prepared from hydroxyl-terminated polydimethylsiloxane dihydric alcohol, diisocyanate and fluorine modified amino silicone oil. The low surface tension and hydrophobic and oleophobic characteristics of the organic fluorine element are utilized, so that migration of dimethyl silicone oil and abrasion of the release agent are reduced. The organic silicone oil molecules containing active amino react with the organic silicone oil with the terminal isocyanate group to generate a large number of acyl semicarbazide bonds. A large number of hydrogen bonds can be formed among the acyl semicarbazide bonds, reversibility is achieved, and the release agent is endowed with good self-healing performance.

The invention relates to a thermally expandable composition comprising: a) At least one thermoplastic polymer TP and / or at least one solid rubber R and b) At least one polymeric blowing agent BA selected from the group consisting of sulfonyl hydrazide-functionalized polymers, sulfonyl semicarbazide-functionalized polymers, carbamate-functionalized polymers, and ureido carbamate-functionalized polymers, wherein the polymeric blowing agent BA has a number average molecular weight (Mn) determined by gel permeation-chromatography (GPC) using polystyrene 0 as standard of at least 500 g / mol, preferably at least 750 g / mol.

The invention discloses a method for determining the content of semicarbazide in a plastic product, and belongs to the technical field of analytical testing, the method is a spectrophotometric method, and the method specifically comprises the following steps: firstly, carrying out derivatization treatment by adopting benzoyl chloride, and then carrying out absorbance detection at 280nm; compared with a liquid chromatography-mass spectrometry method, the method is faster and more efficient in detection and suitable for rapid detection occasions and checkout rooms with low investment cost requirements, the lowest detection capacity of the method is 0.1 mg / L, most quantitative requirements are met, the pretreatment process is simple, the derivation time is short, the operation process is easy to master, and the method is suitable for industrial production. And the result can be obtained only in about 10 minutes in the conventional detection, so that the timeliness and the safety are very high.

The present invention discloses a semicarbazide derivative and its preparation method and application, which belongs to the technical field of anti-lung cancer targeted drugs. The semicarbazide derivative of the present invention can inhibit the growth of H1299 cells in a dose-dependent manner, but has little toxicity to normal lung epithelial cells BEAS-2B. The semicarbazide derivative of the present invention can significantly inhibit the cloning of non-small cell lung cancer cells A549 and H1299, so it has a significant inhibitory effect on the proliferation of non-small cell lung cancer. The semicarbazide derivative provided by the present invention can inhibit the protein expression of GPX4 in non-small cell lung cancer A549 cells, and by inhibiting the protein expression of GPX4, promote the ferroptosis of non-small cell lung cancer cells, thereby playing a role in suppressing tumors.

The currently claimed invention relates to a method for improving the color fastness of a cellulose-based substrate to nitrogen oxides and ozone. The method comprises contacting the cellulose-based substrate with a composition comprising: at least one aminourea compound selected from bis[4-[3-(dimethylamino)ureo]phenyl]methane (I) and 4,4'-hexamethylenebis(1,1-dimethylaminourea) (II); at least one solvent selected from alcohols of formula A, glycol ethers of formula B, glycol ethers of formula C, polyethylene glycol, and water; R 1 -OH-A,R 2 -(OCH2CH2-) n OH-B,R 3 -(OCH2(CH3)CH-) m OH-C, where R 1 Selected from C2-C 10 Straight-chain or branched alkyl groups; R 2 Selected from C1-C6 straight-chain or branched alkyl groups; n is 1, 2 or 3; R 3 Selected from C1-C6 straight-chain or branched alkylene groups; and m is 1 or 2; wherein the cellulose-based substrate is selected from at least one of the following: dyed cellulose-based substrate, printed cellulose-based substrate, and dyed and printed cellulose-based substrate; and (ii) drying.

The invention relates to a polyhydroxymethyl melamine-based PVC (polyvinyl chloride) composite heat stabilizer which is characterized by comprising the following components in percentage by mass: 40-60% of polyhydroxymethyl melamine; 25 to 35% of zinc stearate; 10 to 25% of hydrotalcite; 3-6% of an auxiliary heat stabilizer; the molecular structural formula of the polyhydroxymethyl melamine is shown in the specification, x is 1 or 2, y is 1 or 2, and z is 1 or 2; and the auxiliary heat stabilizer is a beta-diketone type compound or 1, 3-dimethyl-6-aminouracil. The polyhydroxymethyl melamine-based PVC composite heat stabilizer can significantly improve the heat stability of PVC, the initial coloring is slight, and the long-term heat stability is excellent.

The invention relates to a process for producing polyurethanes using a component A comprising a polyhydrazide, a polysemicarbazide, a polysulfonyl hydrazide and / or carbodihydrazide, in particular a polyhydrazide, wherein the component A is employed in the form of a mixture C which further comprises a component B comprising a dispersion medium.

The invention relates to a high-temperature-resistant flame-retardant CPVC (chlorinated polyvinyl chloride) composite material and a preparation method thereof, and belongs to the technical field of high polymer materials. The high-temperature-resistant flame-retardant CPVC composite material comprises the following components in parts by weight: 100 parts of CPVC resin, 4-7 parts of a stabilizer, 0.4-0.8 part of a lubricant, 5-10 parts of calcium carbonate, 10-12 parts of a plasticizer, 1-5 parts of a high-temperature-resistant modifier and 1-3 parts of a modified flame retardant, the phosphorus element in the modified flame retardant forms phosphate during combustion to isolate oxygen and heat, and the boron element forms a glassy covering layer during combustion to synergistically inhibit the generation of smoke; a nitrogen atom of 1, 3-dimethyl-6-aminouracil in the high-temperature-resistant modifier captures alkyl and peroxy free radicals, and a maleimide group enhances an intermolecular acting force and increases the heat resistance of a molecular chain; the high-temperature-resistant flame-retardant CPVC composite material prepared by the invention not only has good high-temperature-resistant and aging-resistant effects, but also has an excellent flame-retardant effect.

The invention belongs to the technical field of water treatment, and relates to a thermosensitive color developing agent F-103 production wastewater treatment method, which comprises the following steps: carrying out multi-stage treatment on wastewater, firstly carrying out alkaline chemical separation reaction on the wastewater, and removing part of acidic polar organic matters such as 3-p-toluenesulfonyl semicarbazide phenol, p-toluenesulfonic acid and the like in water; then carrying out acidic chemical separation reaction to further remove alkaline polar organic matter intermediates MAPOTs and the like in water; then carrying out adsorption reaction by using activated carbon to further remove organic matters and inorganic impurities in the water; and finally evaporating and concentrating, and recovering salt sodium chloride. According to the wastewater treatment method disclosed by the invention, on the premise of solving the toxicity problem of organic matters in the wastewater, the sodium chloride salt in the wastewater is subjected to resource recovery, and the harmlessness of the wastewater and the reduction of hazardous wastes are realized.

The invention discloses 1-(4-aminophenyl)-3-[(4-aminophenyl) carbamoylamino] urea as well as a preparation method and application thereof. The 1-(4-aminophenyl)-3-[(4-aminophenyl) carbamoylamino] urea product is obtained by reacting p-phenylenediamine and diethyl azodicarboxylate under the action of a catalyst. The method is simple in process, milder in reaction condition, easier to control, high in environmental protection property, low in danger coefficient, high in yield and more suitable for industrial application. The product can interact with carbon black to improve the dispersion of carbon black with high specific surface area, can react with carbon-carbon double bonds in natural rubber to form a stable cross-linked network, improves the anti-reversion performance of a rubber material, and has more important social significance and higher economic value.

The application discloses application of a combined inhibitor of copper-molybdenum mixed concentrate in copper-molybdenum flotation separation. The application firstly carries out fine grinding and medicine removing on the copper-molybdenum mixed concentrate; adds the combined inhibitor to inhibit chalcopyrite during the fine grinding process; then adds a collector and a foaming agent to obtain a molybdenum rough concentrate and a copper rough concentrate through roughing; the molybdenum rough concentrate is obtained after being refined, and the copper rough concentrate is obtained after being scanned. The combined inhibitor comprises thiosemicarbazide and thiolactic acid. The dosages of the water-soluble thiosemicarbazide and the thiolactic acid are 0.2-0.5 kg and 0.1-0.2 kg respectively per ton of the copper-molybdenum mixed concentrate. The application can replace the use of toxic inhibitors to reduce environmental pollution, and significantly improve the flotation separation efficiency of copper and molybdenum, and realize efficient separation of copper and molybdenum concentrates.

The utility model belongs to the technical field of toluenesulfonyl semicarbazide production, and particularly relates to a double-decomposition reaction kettle which comprises an outer kettle body and an inner kettle body, the inner kettle body is fixed inside the outer kettle body, and a first rotating shaft and four second rotating shafts are rotatably connected to the inner kettle body through bearings. One end of each of the first rotating shaft and the four second rotating shafts slidably penetrates through the outer kettle body and extends out of the outer kettle body, and first blades are fixed to the surface of the first rotating shaft at equal intervals. According to the reaction kettle disclosed by the utility model, the vertical stirring shaft I and the four transverse stirring shafts II which are obliquely arranged are arranged in the inner kettle body, so that raw materials in the inner kettle body can be more disordered when being stirred, and the uniformity and sufficiency of material mixing are further improved; the damping structure can reduce the vibration of the reaction kettle during operation, so that the risk of material leakage caused by equipment shaking is reduced, and the noise of the reaction kettle during operation can be reduced.

The invention relates to the field of tuning part electroplating processing, and discloses an electroplating process of a high-voltage tuning resonance rod, which comprises the following steps: S1, pretreatment of the resonance rod; s2, performing soaking treatment on the pretreated resonance rod by using a first treatment agent to obtain a primarily treated resonance rod; s3, pre-copper-plating treatment of the primary treatment resonance rod; s4, the resonance rod subjected to copper pre-plating is soaked with a second treating agent, and a pretreated resonance rod is obtained; s5, silver plating treatment, water washing and drying are conducted on the pretreated resonance rod, and the high-voltage-modulation resonance rod is obtained; the first treatment agent is prepared from sodium lignin sulfonate, hydroxypropyl trimethyl ammonium chloride chitosan and water, and the second treatment agent is prepared from sodium 2-acrylamido-2-methylpropanesulfonate, 4-ethyl-3-thiosemicarbazide, acetylchitosamine, polyethylene glycol and water. The plating layer of the high-voltage resonance adjusting rod has the advantages of being fine and firm, is not prone to being influenced by high-voltage corona under the condition of bearing radio frequency high voltage for a long time, and is good in reliability.

The application discloses a fluorescent compound capable of naked-eye detection of aminourea and a preparation method and application thereof. A PPAB compound with electron push-pull action is obtained through condensation reaction of a pyrrolopyrrolodione and a nitrogen-containing aromatic primary amine, coordination with BF3.Et2O, and [2+2] cycloaddition-anti-electric ring-opening reaction with tetracyanoethylene. In an organic solvent, the PPAB and aminourea perform irreversible chemical reaction, high-sensitivity detection of aminourea is realized, and the application has the characteristics of simple operation, rapid reaction, good selectivity, colorimetric and fluorescent dual-mode detection and the like.

Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.

This invention relates to the field of photocurable adhesives, specifically to a UV-curable, positionable temporary masking adhesive and its processing technology. It addresses the problems of slow curing speed, low mechanical properties, and poor peel strength in existing temporary masking adhesives. Modified photosensitive polyurethane is used as the core film-forming resin. Its rigid oligocellulose skeleton imparts excellent modulus and thermal stability to the adhesive layer. The chain extender introduces amide groups that form a dense, strong hydrogen bond network between molecular chains, enhancing cohesive strength and tear resistance. Simultaneously, the pyrimidine ring provided by 2,4-dihydroxypyrimidine-5-carboxylic acid forms dynamic coordination bonds with zinc ions dissociated from zinc acetate, enhancing the mechanical properties after curing. A rapid decrease in viscosity can be achieved under secondary triggering. The highly efficient hydrogen abstraction initiation capability of the nano-photoinitiator enables rapid photocuring. Its cage-like rigid skeleton nano-sizes the photoinitiator and utilizes steric hindrance to reduce migration rate. These two elements work synergistically to achieve rapid positioning curing, high strength, and full-sheet peeling.

The invention discloses a method for chemically purifying aldehyde VOCs (volatile organic compounds) in leather, an aldehyde catching agent is added in a spraying manner in a pre-prime coating stage in a leather coating procedure, and the method specifically comprises the following steps: 1) adding semicarbazide hydrochloride, glycoluril, sodium lauroyl glutamate and polyacrylamide into deionized water, and uniformly stirring to obtain the aldehyde catching agent; 2) uniformly adding the aldehyde trapping agent prepared in the step 1) to the meat surface of the leather in a spraying manner in a pre-prime coating stage in a leather coating procedure, standing until the aldehyde trapping agent is absorbed, drying, and entering a subsequent procedure after drying; the chemical purification method breaks through the limitation of traditional physical adsorption, effectively inhibits environmental release of aldehyde VOCs in leather products through an in-situ chemical immobilization strategy, has the characteristics of high reaction efficiency (gt, 90%), strong environmental durability, excellent eco-friendliness and the like, and provides an innovative solution for control of volatile aldehyde pollutants in the leather industry.

The invention relates to a compound containing amino and ureido and having Candida albicans growth inhibition activity, in particular to a 1, 4-diphenyl semicarbazide compound and a preparation method thereof, the compound is simple in structure, short in synthetic route and efficient; the compound can be applied to preparation of candida albicans antibacterial drugs. The molecular structural formula of the 1, 4-diphenyl semicarbazide compound is shown in the specification, and R1 and R2 are hydrogen atoms, halogen atoms, cyano groups, methyl groups, ethyl groups, propyl groups, methoxyl groups, trifluoromethyl groups and trifluoromethoxyl groups.

The invention relates to the technical field of organic polymer composite material auxiliaries, and particularly discloses a release agent with self-healing performance and a preparation method and application thereof. The release agent is prepared from the following components in parts by weight: 1.0 to 10.0 parts of self-healing organic silicon resin, 0.1 to 2.5 parts of simethicone, 0.001 to 0.05 part of stabilizer and 86.0 to 99.0 parts of organic solvent, the self-healing organic silicon resin is prepared from hydroxyl-terminated polydimethylsiloxane dihydric alcohol, diisocyanate and amino silicone oil. Amino silicone oil molecules with an ABA triblock structure are utilized to react with organic silicone oil with an end isocyanate group, and a large number of acyl semicarbazide bonds are generated. A large number of multiple hydrogen bonds are formed between acyl semicarbazide bonds and urethane bonds, and the hydrogen bonds have reversibility, so that the release agent is endowed with good self-healing performance. The invention further provides a mold with the surface coated with the mold release agent, and the mold is low in abrasion in use and can be used for many times.

The invention relates to a thiopropane trithiol compound as shown in a formula I and a preparation method thereof. The compound is thiol containing a thioether bond and three sulfydryl groups, and the preparation method of the compound comprises the following three steps: step 1, carrying out vulcanization reaction on sulfydryl propylene glycol and a sulfur halide reagent in a solvent to obtain sulfo-polyhydric alcohol; 2, carrying out a substitution reaction of changing hydroxyl into sulfydryl in an acid environment by using thio-polyol and thiosemicarbazide, so as to obtain an intermediate product isothiourea salt; and 3, carrying out hydrolysis catalysis on the isothiourea salt to finally generate the thiopropane trithiol compound. The thiopropane trithiol compound monomer disclosed by the invention is high in light transmittance, large in refractive index and low in yellow index; the preparation method is easy in reaction route control and short in reaction time. # imgabs0 #

The present invention provides preparation of a semicarbazide-sensitive amine oxidase inhibitor and use thereof. In particular, disclosed in the present invention are a compound as represented by formula I, or a stereoisomer or a racemate or a pharmaceutically acceptable salt of the compound. Also disclosed in the present invention is that the compound can inhibit semicarbazide-sensitive amine oxidase.

The invention relates to the technical field of hydrogel, in particular to a dual-curing hydrogel precursor solution, 3D printing hydrogel and application thereof. The dual-cured hydrogel precursor solution is prepared from the following raw materials in parts by weight: 0 to 2 parts of acrylic resin, 8 to 10 parts of acrylic monomer, 0.02 to 0.05 part of thermal initiator, 0.14 to 0.15 part of water-soluble photoinitiator and 1 to 1.2 parts of solvent; wherein the acrylic acid monomer comprises N-acryloyl glycine amide and N-acryloyl semicarbazide; the solvent comprises a phosphate buffer solution. The hydrogel prepared from the hydrogel precursor solution provided by the invention has excellent tensile strength and micro-nano processing precision.

The invention discloses a high polymer bonded explosive with mild and self-healing damage, a polyamidosemicarbazide binder and a preparation method of the high polymer bonded explosive. The high polymer bonded explosive with mild and self-healing damage comprises the following components: (a) a high-energy explosive; and (b) a polyamidosemicarbazide binder, the polyamidosemicarbazide binder has a disulfide bond structure and also contains multiple hydrogen bonds, and can be subjected to reversible exchange or reconstruction reaction under a mild heating condition, and a polymer molecular chain has sufficient movement ability at a damaged part of the high polymer bonded explosive, flows and fills a damaged interface, so that the damage of the high polymer bonded explosive to the damaged part is avoided. The disulfide bond and the hydrogen bond can be formed again, so that the microstructure and the strength of the explosive are recovered.

Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.