264 results about "Semicarbazide" patented technology

The invention discloses an iridium complex as well as a preparation method and an application thereof. The iridium complex is monochloro-mono-meta-methoxybenzaldehyde-4-phenyl-3-thiosemicarbazide-pentamethyl cyclopentadienyl iridium (III) and can be applied to preparation of medicines for treating cancers, and the structural formula of the complex is shown in the specification.

The invention relates to an impregnated resin, an impregnated film adhesive, manufacturing methods of the impregnated resin and the impregnated film adhesive, and a laminated floor. According to the present invention, the impregnated resin comprises a melamine formaldehyde resin, urine phthalic acid, and a formaldehyde scavenger, wherein 810-860 parts by weight of formaldehyde, 330-350 parts by weight of water, 700 parts by weight of melamine, 30-40 parts by weight of urea and 10-20 parts by weight of caprolactam are subjected to thermal insulation, then 40-65 parts by weight of urea, 20-40 parts by weight of diethylene glycol and sodium hydroxide are added to prepare the melamine formaldehyde resin, 5 parts by weight of a semicarbazide hydrochloride is dissolved in 12-15 parts by weight of water, 7-8 parts by weight of crystallized sodium acetate is dissolved in 5-7 parts by weight of dimethylformamide, the two obtained solutions are mixed to obtained the formaldehyde scavenger, and the impregnated resin is prepared from 1000 parts by weight of the melamine formaldehyde resin, 5-8 parts by weight of the urine phthalic acid, and 10-15 parts by weight of the formaldehyde scavenger; base paper is impregnated in the impregnated resin and dried to prepared the impregnated film adhesive; and the impregnated film adhesive and a high density fiber plate are subjected to hot pressing so as to prepare the laminated floor.

This invention offers a method for forming multilayer coating film by successively applying onto a coating object a water-based first coloring paint, water-based second coloring paint and clear paint, and simultaneously baking the resultant first coloring coating film, second coloring coating film and clear coating film, in which the water-based first coloring paint (A) comprises polyester resin and curing agent, the polyester resin containing benzene ring and cyclohexane ring in its molecules, their combined content in the polyester resin being within a range of 1.0-2.2 mols/kg (solid resin content); and that the curing agent is at least one compound selected from the group consisting of isocyanate group-containing compound, oxazoline group-containing compound, carbodiimide group-containing compound, hydrazide group-containing compound and semicarbazide group-containing compound. According to this method, multilayer coating film excelling in smoothness, distinctness of image, chipping resistance and water resistance can be formed by 3-coat-1-bake system.

The invention relates to a goserelin acetate solid-phase synthesis method, which comprises the following steps: HBTU/DIPEA is employed as a condensation system, Fmoc-Ser-OH, Fmoc-Trp-OH are successively coupled; a whole-protection lysate with corresponding voluminal amount according to 10 times of resin weight is added, a carrier 2-CTC Resin in an intermediate is removed, all side chain protective groups are reserved; the whole-protection lysate is adjusted to slight alkaline by using DIPEA(N,N-diisopropylethylaine), semicarbazide hydrochloride and PyBop(1H-benzotriazole-1-oxygen tripyrrole alkyl hexafluorophosphate) (used for a coupling agent of peptide) are added in the whole-protection lysate for reaction coupling, a goserelin peptide solution with the side chain protective group is obtained; the lysate with 20% of TFA/DCM is added in a freezing ether for settling to obtain the white solid crude peptide; the white solid crude peptide is dried under vacuum for solving by methyl alcohol, ammonium formate and Pa/c are added for a hydrogenation reaction to remove the side chain protective group in a peptide sequence. According to the invention, side reaction phenomena can be avoided, target peptide purity is increased, yield is high, operation is convenient and feasible, the intermediate can be tracked and controlled, and the whole process is benefit for enlarged production.

The invention discloses a making method of hapten and holoantigen of semicarbazide derivant, which is characterized by the following: establishing immunity method to detect SEM in the food through ELISA method; testing SEM qualitatively and quantitatively; fitting for SEM agent box (ELISA agent box, colloidal gold test paper and so on) of edible animal tissue.

The invention belongs to the technical field of photocatalysis and discloses a carbon dot modified oxygen-doped carbon nitride photocatalyst as well as a preparation method and an application thereof.The method comprises steps as follows: citric acid and urea are added to ultrapure water and subjected to reaction at 170-190 DEG C after being ultrasonically dissolved, a mixed solution is cooled toroom temperature, centrifuged, dried and subjected to constant-volume treatment with the ultrapure water, and a CDs solution is obtained; semicarbazide hydrochloride is subjected to calcining reaction at 540-560 DEG C, cooled, ground and sieved, and O-C3N4 is obtained; O-C3N4 is added to a crucible, the ultrapure water and ethanol are added, then the CDs solution is added, after ultrasonic dissolving, water-bath heating and stirring are performed until the mixture is dry, the calcining reaction is performed at 280-320 DEG C, a product is cooled, ground and sieved, and the photocatalyst is obtained. With the adoption of a thermo polymerization method, the synthetic process is simple, repeatability is good, and basic conditions for large-scale production are provided; the CDs in the photocatalyst can convert long-wavelength light into short-wavelength light, the catalytic effect is improved, and diclofenac can be degraded under different light sources.

An amine compound serving as a semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, and an application thereof in medicines that can be used for treating inflammation and/or inflammation related diseases, diabetes and/or a disease related diabetes, psychiatric disorder, ischemic disease, vascular disease, fibrosis, or tissue transplant rejection.

The invention belongs to the technical field of building materials and especially relates to a wear-resistant wood-plastic profile and a preparation method thereof. The wear-resistant wood-plastic profile is prepared from the following raw materials (by weight): 20-60 parts of walnut shell flour, 10-26 parts of peanut shell powder, 20-40 parts of polyethylene, 5-12 parts of glyceryl triacetate, 5-10 parts of silicone powder, 3-8 parts of polytetrafluoroethylene powder, 4-9 parts of di-n-butyl phosphate, 3-7 parts of cyclohexane dicarboxylate, 3-8 parts of diethylene glycol dibenzoate, 2-7 parts of tetramethyl divinyl disiloxane, 1-5 parts of vinyl trichlorosilane, 2-8 parts of 1,3-dimethyl-6-semicarbazide pyrimidine, 3-8 parts of alkyl glycoside, 1-5 parts of 1-vinyl imidazole and 1-6 parts of dialkyl diphenylamine. The invention also provides a preparation method of the wear-resistant wood-plastic profile. The wear-resistant wood-plastic profile has characteristics of aesthetic property, high wear resistance, waterproofness and skid resistance, durability and corrosion resistance, no release of formaldehyde and the like. In addition, the preparation technology is simple.

The invention relates to a method for preparing a flame-retardant core-shell acrylate resin coating and adhesive. The method comprises the following steps: adding water, an emulsifier and methacrylic acid into a reaction container, heating to the temperature of 60 DEG C, and stirring for 30 minutes; adding a monomer A, emulsifying for 45 minutes, heating to the temperature of 65 DEG C, introducing reflux water, heating to the temperature of 80 DEG C, preserving the temperature, dripping an initiator within 0.5-1 hour, and reacting for 2-3 hours after the dripping operation is finished, thereby obtaining core layer emulsion; simultaneously dripping a monomer B and an initiator into the obtained core layer emulsion within 0.5-1 hour, preserving the temperature to be 80 DEG C after the dripping operation is finished, and reacting for 2 hours; adding an inrumescent flame retardant, reacting at 80 DEG C for 2 hours, dripping a cross-linking agent, preserving the temperature to be 75-95 DEG C, reacting for 1-2 hours, cooling to the temperature of 50 DEG C, adding an emulsifier, semicarbazide and thiamine hydrochloride, reacting for 30 minutes, and adding ammonium hydroxide to regulate the pH value to 7-8, thereby obtaining the flame-retardant core-shell acrylate resin coating and adhesive. According to the obtained acrylate resin, the defect that the traditional acrylate resin is sticky when heated and fragile when cooled can be improved, and the flame-retardant property of the acrylate resin can be improved.

The invention relates to a formaldehyde eliminating agent and a preparation method thereof, in particular to an eliminating agent for eliminating free formaldehyde in plate bonding agents. The formaldehyde eliminating agent comprises the following ingredients in percentage by weight: 4 to 8 percent of semicarbazide, 1 to 3 percent of xanthan gum, 5 to 7 percent of chitosan, 12 to 18 percent of stearate and the balance anion water. The ingredients are prepared into the formaldehyde eliminating agent through the steps of drying, dissolution, heating, stirring, mixing and the like. The formaldehyde eliminating agent can fast take reaction with formaldehyde, toxic and harmful byproducts and foreign materials can not be generated, in addition, the slow release effect is realized, and the effect is more durable.

The invention discloses a molecular sieve material for efficiently adsorbing environmental carbon dioxide and a preparation method thereof. The molecular sieve material is composed of molecular sieves and one or more organic amines linked by a chemical bonding form, wherein the organic amine is bonded to an inner and outer surface of the molecular sieve, and the molecular sieve material for efficiently adsorbing environmental carbon dioxide removes carbon dioxide from the environment to purify the air. The molecular sieve can be a ZSM-5 molecular sieve, an MCM-41 molecular sieve or an MOR molecular sieve. The organic amine can be one or more of ethanolamine, methyldiethanolamine, triethanolamine, triethylene tetraamine, tetraethylene pentamine, polyethylene imine, polyacrylamine or semicarbazide.

The invention relates to a semicarbazide dihydroartemisinin derivative (general formula I) or a pharmaceutically-acceptable hydrate and salt of the semicarbazide dihydroartemisinin derivative, wherein R is H and various kinds of alkyls; the alkyls can be randomly substituted by substituent groups of halogens, amino groups, substituted amino groups, carboxyls, hydroxyls, ester groups, cyano groups, nitryls, aryls and substituted aryls; and Z is O, S and NH. The semicarbazide dihydroartemisinin derivative disclosed by the invention has a remarkable effect on inhibiting Hela and A549 cells so as to have a relatively-good anti-tumor effect. The invention discloses a preparation method of the semicarbazide dihydroartemisinin derivative.

The invention relates to a poly semicarbazide acid ester flame retardant foam plate and a preparation method and belongs to the technical field of flame retardant foam plates. A foam hole wall material comprises two components which are formed by interpenetration of polymer molecular chains, the first component is a poly semicarbazide acid ester crosslinking polymer, and the second component is chlorinated linear flame retardant polymer. The polyreaction of the polymer of the first component is synchronously completed by a poly semicarbazide acid ester precursor with plate forming, the second component is mixed and dispersed in the slurry of the poly semicarbazide acid ester precursor in advance, and a chlorinated hydroxyl-terminated polybutadiene interfacial compatibilizer is added to the mixed slurry. A mixed solvent is add to the mixed slurry and used as a hole forming agent and a cosolvent for the two polymers. The mixed slurry is processed by extrusion or mould pressing and moisture post-cure reaction. The prepared serial foam plate has the characteristics of high multiplying power, light weight, high thermal deformation temperature, low thermal conductivity, high strength, high modulus and V0 grade of flame retardance.

The invention discloses a method for tetraene methyl CAS. A dihydroxy progesterone dehydrogenation complex serves as a raw material and is sequentially subjected to a 11 alpha hydroxyl elimination reaction and a 17 alpha hydroxyl elimination reaction to obtain tetraene methyl CAS. According to the method, the dihydroxy progesterone dehydrogenation complex serves as the raw material for the first time, the mole yield of each step is over 90%, the total mole yield is over 85%, the total weight yield ranges from 72% to 76%, and the method has the advantages that the raw material conversion rate is high, few by-products are generated, the product purity is high, the process route is short, and cost is low; an existing 17 alpha hydroxyl elimination process is improved, tetrahydrofuran is used as reaction solvent, semicarbazide hydrochloride is used as an eliminating reagent, monoacid of low fatty acid is used as a catalyst, selectivity of 17 alpha hydroxyl elimination is improved, and the yield of 17 alpha hydroxyl elimination is increased.

The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula:

or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R¹ to R¹¹ are as defined herein.

The invention discloses thiouracil derivatives containing oxadiazole/thiadiazole, and further provides a method for synthesizing the thiouracil derivatives. The general chemical formula of the thiouracil derivatives is shown in figure I or figure II, wherein R1, R2 and R3 are hydrogen or halogen or aryl-. The method includes the steps of making aromatic aldehyde react with ethyl cyanoacetate and thiourea under the catalysis of piperidine to obtain a compound III, making aromatic aldehyde react with semicarbazide to obtain a compound IV, making the compound IV react with bromine to obtain a compound V, making the compound V react with benzoyl chloride to obtain a compound VI, making the compound VI and the compound III have a reflux reaction under the catalysis of potassium carbonate to obtain the general chemical formula I, making aromatic acid react with thiosemicarbazide to obtain a compound VII, making the compound VII react with benzoyl chloride to obtain a compound VIII, and making the compound VIII react with the compound III under the catalysis of potassium carbonate to obtain the general chemical formula II. The adopted method is simple, easy to operate and beneficial to large-scale production; it is verified that the prepared compound has high bacteriostatic activity and can be widely applied in bacteriostatic drug preparations.

The invention discloses an organism for synthesizing metal organic frame based on Co(II) ion. The structural formula is shown in the specification. The invention further provides a synthesis method of the organism. The synthesis method comprises the following steps of: firstly, carrying out cyclization reaction on 3-bromine-4-methyl benzoic acid and semicarbazide hydrochloride so as to prepare a midbody A; and secondly, carrying out SuZuki reaction on the midbody A with pyridine-3-boric acid so as to prepare the organism. The invention further respectively provides three metal organic frames based on the Co(II) ion, a preparation method of the metal organic frames, and an application of the metal organic frames as an initiator in anion exchange. The organism has the beneficial effects that the compound belongs to organic-inorganic composite super-molecule materials, is simple to operate, low in cost and rapid in response, and realizes visible sensation of anions and the effective separation of the anions.

The invention relates to the field of daily supplies, in particular to an air purifying agent containing plant extracts. The air purifying agent containing the plant extracts comprises components with parts by weight: hypochlorous acid 10-12 parts, nanometer titania 5-10 parts, kaoline 7-11 parts, monopotassium phosphate 6-9 parts, citric acid 3-5 parts, acetic ether 25-35 parts, semicarbazide 20-30 parts, water 50-70 parts and plant extracts 5-10 parts. The air purifying agent containing the plant extracts is long in duration time, effectively removes house smell, is strong in adsorptivity, safe and environmentally friendly, simple to use and low in cost, and enhances absorption effect of formaldehyde by mixing with the plant extracts.

The invention relates to a semicarbazide derivatization reagent and a rapid detection card thereof. The derivatization reagent is aldehyde benzoic acid with a specific small molecular marker, the aldehyde benzoic acid can react with the amino of a metabolite through a aldehyde group to form a metabolite-aldehyde benzoic acid derivative with a specific molecular marker, the specific molecular marker can bind with a ligand on a magnetic bead, through magnetic bead separation, a semicarbazide derivatization product marked magnetic bead can be obtained, and the magnetic bead can be added dropwise directly on a rapid chromatographic card to perform detection. The reagent provided by the invention utilizes the advantages of lateral chromatography, simplifies the separation and purification steps of furan characteristic metabolite derivatives, and reduces the detection time and operation error.

The invention relates to a preparation method of a pyrazolone/polymer composite photochromic film. A high-performance water-insoluble pyrazolone photochromic material, i.e. 1, 3-diphenyl-4-(3'-bromobenzylidene)-5-pyrazolone-shrinking phenyl semicarbazide (DP3BrBP-PSC) is used as a photochromic unit, water-soluble high polymers, i.e. hydroxypropyl methyl cellulose (HPMC) and polyvinyl alcohol (PVA) are used at the same time, distilled water is used as solvent, a physical doping dispersion method is used and continuous agitation is conducted to obtain composite material suspension; and after the suspension is statically placed in a dark place and is defoamed and a pouring method is used for preparing the pyrazolone/polymer composite photochromic film which has the advantages of high photochromic property, even texture and good transparency, flexibility and mechanical property. The preparation method has the advantages of simplicity in operation and lower cost.

The invention relates to a renewable fluorescent probe for selectively detecting bioactive sulfydryl compound in cells and a synthetic method and the application thereof. Coumarin-3-sulfydryl compound with R1, R2, R3, R4 and R5 substituents is dissolved in dry organic solvent; thiosulfate semicarbazide which is dissolved in organic solvent and provided with an R6 substituent is dripped slowly under refluxing stirring for reaction; the mixture is filtered to remove the organic solvent and then is dried in vacuum to obtain a ligand; the ligand is dissolved in the dry organic solvent; HgX2 which is dissolved in the organic solvent is dripped slowly under refluxing stirring for reaction so as to obtain solid precipitate; the mixture is filtered and then the solid precipitate is dried in vacuum to obtain the fluorescent probe of formula I. The fluorescent probe can be used for detecting the bioactive sulfydryl compound in a biosystem, analyzing and detecting the bioactive sulfydryl compound in biological living cells and living tissues, detecting fluorescent imaging as well as clinically and pharmaceutically detecting the bioactive sulfydryl compound in pathological tissues.