75 results about "Azine" patented technology

The disclosure provides compounds, e.g., compounds of Formula I, and their use in treating medical diseases or disorders, such as cancer. The compounds are contemplated to be modulators of Ras (e.g., K-Ras).

The present disclosure provides compounds and their methods of use. In particular, the compounds of the present disclosure may be useful for inhibiting RAS proteins, such as KRAS proteins. The disclosed compound may be used in the treatment of cancer and be highly selective for KRAS proteins having the G12D mutation. Alternatively or additionally, said compounds may have broad spectrum activity across a range of KRAS proteins.

To provide a polyamide composition which is excellent in machine physical properties, heat resistant aging properties at 180°C for a long term of about 2,000 hours, and electric characteristic, is suppressed in bleedout of an additive agent at 80°C and a relative humidity of 95%, makes an additive agent hardly elute in water, and enables obtaining a molded article having excellent external appearance.SOLUTION: A polyamide composition contains: (A) polyamide; 0.1 pt.mass or more and 3 pts.mass or less of (B) branch type polyamine based on 100 pts.mass of the (A) polyamide; 0.05 pt.mass or more and 3 pts.mass or less of (C) steric hindrance phenol; and 0.01 pt.mass or more and 0.5 pt.mass or less of (D) azine dye or phthalocyanine dye. A concentration of (F) halide ion measured by combustion ion chromatography is 500 mass ppm or less based on the total mass of the polyamide composition.SELECTED DRAWING: None

The invention belongs to the technical field of photocatalytic materials, and discloses a triazine-hydrazine bond-based efficient water photolysis COF material as well as a preparation method and application thereof. The material is prepared by carrying out condensation polymerization reaction on benzo [1, 2-b: 3, 4-b ': 5, 6-b'] trithiophene-2, 5, 8-tricarboxaldehyde, 4, 4 ', 4' '-(1, 3, 5-triazine-2, 4, 6-triyl) tribenzaldehyde and hydrazine hydrate. An intramolecular donor-acceptor (D-A) electronic structure is constructed by introducing an electron-rich benzotrithiophene unit and an electron-deficient triazine unit, and the electron-deficient triazine unit and the electron-deficient triazine unit are connected through a full-conjugated azine bond, so that separation and transmission of photo-generated charges are effectively promoted. The preparation method adopts a solvothermal method, and a high-crystallinity product is obtained through acid catalysis and degassing crystallization. The material has high specific surface area and excellent chemical stability, and shows high-efficiency photocatalytic water splitting hydrogen production activity and good cycle stability under the driving of visible light.

The present disclosure provides compounds, in part, compounds having Formula (I) or Formula (II), and their use in the treatment of medical diseases or disorders, such as neurodegenerative diseases, e.g., Parkinson's disease. Pharmaceutical compositions and methods of making the compounds of the present disclosure are provided. These compounds are envisaged to be modulators, e.g., inhibitors, of cyclic ADP ribohydrolase (CD38).

Provided are: a material for organic electroluminescent elements, which is capable of obtaining an organic EL element that is driven at a low voltage, emits light at high efficiency, has long-life characteristics, and is practically useful; and an organic electroluminescent element obtained using the material. A mixed material for an organic electroluminescent element, which contains a compound represented by general formula (1) and a cyclic azine compound represented by general formula (10), and an organic electroluminescent element formed using the mixed material. And m represents the number of repetitions and is 2 or 3. Ar1 is a substituted or unsubstituted aromatic hydrocarbon group having 6-20 carbon atoms or the like, and R2-R7 are each independently hydrogen, a substituted or unsubstituted aromatic hydrocarbon group having 6-20 carbon atoms or the like. Ar2 and Ar3 are each independently a substituted or unsubstituted C6-20 aromatic hydrocarbon group or the like, and L1 is a single bond or a substituted or unsubstituted phenyl group.

A method for selectively controlling weeds in rice, which comprises applying to the crop cultivation area an effective amount of a herbicide A selected from a compound of formula (I) and salts of the compound of formula (I) wherein R1 to R8 are as defined above.

The present invention relates to the technical field of nano-carbon materials, and in particular to a kind of synthetic method of electrochemically active azine alkyne carbon material. Calcium carbide (CaC2) and cyanuric chloride (C3Cl3N3) are uniformly mixed by synthetic method of the present invention, then added into a ball mill and carried out mechanochemical reaction, and the product obtained is washed with 0.1mol / L dilute nitric acid, acetone and deionized water, and then the washed product is freeze-dried to obtain azine alkyne carbon material. The present invention utilizes cyanuric chloride monomer and calcium carbide to synthesize C N heterocyclic azine alkyne carbon material in a controllable structure for the first time through the method for mechanochemical action, while realizing its morphology and structure controllable preparation; During the process, no solvent is needed, operating conditions are mild, chemical effect is remarkable, principle is simple, raw material cost is low and easy to industrial production, the azine alkyne carbon material obtained is made as lithium ion battery negative electrode material, the performances such as charge and discharge capacity, cycle life of composite material can be improved, and it is of great significance for the development of new energy.

This invention relates to the field of electrochemical organic synthesis technology, specifically providing an electrochemically promoted method and application for the synthesis of indole-benzo[selenium]azine ketones. A C3-selenoindole derivative, an organoselenium catalyst, an electrolyte, and an acid are added to an organic solvent to form a reaction system. A graphite felt is used as the anode, and a platinum sheet as the cathode, and a constant current reaction is carried out at room temperature in an air atmosphere. After the reaction is complete, the reactants are post-treated to obtain indole-benzo[selenium]azine ketones. The obtained compounds exhibit significant anti-inflammatory and anti-ulcer dual activities, achieving dual anti-inflammatory and anti-ulcer effects. This solves the problem that traditional NSAIDs only have anti-inflammatory properties but easily cause gastrointestinal damage, and has value for further research and application.

Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided, which are useful for inhibiting Drp1 and treating various Drp11-mediated conditions or diseases. JPEG2026510505000203.jpg3055

The present disclosure relates to an organic light emitting device. In particular, the present disclosure relates to an organic light emitting diode and an organic light emitting device each of which includes at least one emitting material layer comprising an anthracene-based host substituted with at least one deuterium and a boron-based dopant, at least one electron blocking layer comprising an aryl-substituted amine-based compound, and optionally at least one hole blocking layer comprising at least one of an azine-based compound and a benzimidazole-based compound. The organic light emitting diode and the organic light emitting device has improved luminous efficiency and enhanced luminous lifespan.

A method for selectively controlling weeds in corn, which comprises applying to the crop cultivation area an effective amount of a herbicidal mixture comprising as a component 1) a herbicide A of the formula (I) wherein R1 to R8 are as defined above and as component 2) at least one further compound selected from compounds B.

The invention relates to the use of at least one organic dialkyl dicarbonate for reducing the content of acetone azine and / or butanone azine in an aqueous polyurethane-polyurea dispersion containing at least one polyurethane-polyurea and acetone azine and / or butanone azine; furthermore to a process for producing an aqueous polyurethane-polyurea dispersion having a reduced content of acetone azine and / or butanone azine; to an aqueous polyurethane-polyurea dispersion containing at least one polyurethane-polyurea and at least one alkyl carbazate; and to an article, cosmetic, coating, adhesive layer, coating formulation, adhesive formulation and / or cosmetic formulation obtainable therefrom.

The present disclosure relates to an OLED that includes a first electrode; a second electrode facing the first electrode; a first emitting material layer including a first host, a second host and a blue dopant and positioned between the first and second electrodes; a first electron blocking layer including an electron blocking material of a spirofluorene-substituted amine derivative and positioned between the first electrode and the first emitting material layer; and a first hole blocking layer including a first hole blocking material of an azine derivative and positioned between the second electrode and the first emitting material layer, wherein the first host is an anthracene derivative, and the second host is a deuterated anthracene derivative.

A cyclic azine compound of formula (1) is provided. A material for an organic light emitting diode containing the cyclic azine compound of formula (1) is also provided. An organic light emitting diode containing the cyclic azine compound which exhibits both excellent driving voltage characteristics and excellent current efficiency characteristics is also provided.

A method for selectively controlling weeds in cereals, which comprises applying to the crop cultivation area an effective amount of a herbicide A selected from a compound of formula (I) and salts of the compound of formula (I) wherein R1 to R8 are as defined above.

A method for selectively controlling weeds in rice, which comprises applying to the crop cultivation area an effective amount of a herbicidal mixture comprising as a component 1) a herbicide A of the formula (I) wherein R1 to R8 are as defined above and as component 2) at least one further compound selected from compounds B.

The present invention relates to a process for providing halogenated 5,6-difluoro-2- methoxybenzenamine and 4,5,6-trifluoro-2-methoxybenzenamine. Further it relates to a process for converting it to substituted azine compounds with herbicidal activity.

The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as PAR-2 inhibitors / antagonists, which renders these compounds highly advantageous for use in therapy, particularly in the treatment or prevention of pain, an autoimmune disorder, an autoinflammatory disorder, an inflammatory disorder, a central nervous system disorder, spinal cord injury, a metabolic disorder, a gastrointestinal disorder, a cardiovascular disorder, a fibrotic disorder, a respiratory disorder, a skin disorder, an allergic disorder, or cancer.

The present invention discloses a flame-retardant PBT composition, which comprises the following components by weight: 80 parts of PBT resin, 6-20 parts of brominated polymer flame retardant, 1-11 parts of antimony-containing flame retardant synergist, and also comprises azine molecules, wherein the weight part of the azine molecules is 0.5-20 wt% of the brominated polymer flame retardant. By adding a specific content of azine molecules, the present invention can effectively improve the precipitation of the brominated polymer flame retardant.

The present disclosure relates to an organic light emitting diode that includes at least one emitting material layer including an anthracene-based host and a boron-based dopant, at least one electron blocking layer including an amine-based compound substituted with at least one fused aromatic or hetero aromatic ring, and optionally at least one hole blocking layer including an azine-based compound or a benzimidazole-based compound. The organic light emitting diode has enhanced luminous efficiency as well as excellent luminous lifetime.

The present disclosure relates to an OLED, which includes: a first electrode; a second electrode facing the first electrode; a first light-emitting material layer located between the first electrode and the second electrode and including a first matrix, a second matrix, and a blue dopant; a first electron blocking layer located between the first electrode and the first light-emitting material layer and including an electron blocking material of a spirofluorene-substituted amine derivative; and a first hole blocking layer located between the second electrode and the first light-emitting material layer and including a hole blocking material of an azine derivative, wherein the first matrix is an anthracene derivative and the second matrix is a deuterated anthracene derivative.

The present invention refers to a plant or plant part comprising a polynucleotide encoding a wildtype or mutated cellulose synthase (CESA) polypeptide, the expression of said polynucleotide confers to the plant or plant part tolerance to CESA-inhibiting herbicides, such as azines.

This invention discloses a dithiophosphoryl-substituted azine compound and its synthetic method, belonging to the field of organic synthesis technology. The synthetic method uses azine compounds, phosphorus pentasulfide, and alcohols as substrates. In a membrane-free electrolytic cell, using tetrabutylammonium bisulfate as the electrolyte and acetonitrile as the solvent, a three-component dehydrogenation coupling reaction is achieved by constant current electrolysis at room temperature. No metal catalyst or external chemical oxidant is required. Inexpensive phosphorus pentasulfide serves as both the sulfur and phosphorus source. By controlling the electrolysis time, mono- or bis-dithiophosphoryl-substituted azine compounds can be selectively prepared with moderate to excellent product yields. Mechanistic studies show that the reaction proceeds via a free radical-mediated pathway. This method is mild, simple to operate, and has a wide range of applicable substrates, meeting the requirements of green chemistry and providing a new route for the efficient synthesis of functionalized phenoxazine derivatives.

The present invention relates to a solvent system specific to fractionation by liquid-liquid extraction, particularly by centrifugal partition chromatography, of a PVC-based feedstock comprising a PVC polymer and at least one additive. The system comprises two non-miscible liquid phases A and B, each comprising an organic solvent or a mixture of organic solvents selected from the same list consisting of ketones, amides, azines, esters, ethers, halogenated solvents, hydrocarbons, sulfur-containing solvents, and dihydrolevoglucosenone. The partition coefficient of the PVC polymer in the solvent system (ratio of the mass concentrations of the PVC polymer dissolved in phase B and in phase A) tends towards zero, and the partition coefficient of the additive in the solvent system (ratio of the mass concentrations of the additive dissolved in phase B and in phase A) is greater than or equal to 0.05.

The application provides a sulfonic acid solid acid catalyst and a preparation method thereof and a method for catalyzing keto-nitrogen isomerization into 2-pyrazoline, and belongs to the technical field of novel aerospace fuels, so as to solve the technical problems of catalyst separation and recovery difficulty and large acid-containing wastewater discharge in the keto-nitrogen isomerization cyclization method catalyzed by a homogeneous acid. The solid acid catalyst mainly comprises methyl sulfonic acid and a carrier amorphous silica, and the main feature of the solid acid catalyst is a high B acid center. In addition, the application provides a method for synthesizing 2-pyrazoline by catalyzing keto-nitrogen isomerization with a sulfonic acid solid acid catalyst, compared with a traditional homogeneous acid method, the catalyst can be easily separated from the reaction system and can be recycled, so that the production cost is reduced; the generation of a large amount of acid-containing wastewater in the removal process of the acid catalyst is solved, so that the wastewater treatment cost is greatly reduced; the method has high catalytic efficiency, and the catalyst can be recycled for three times, so that the catalytic efficiency is maintained.

The present disclosure relates to an OLED that includes a first electrode; a second electrode facing the first electrode; a first emitting material layer including a first host, a second host and a blue dopant and positioned between the first and second electrodes; a first electron blocking layer including an electron blocking material of a spirofluorene-substituted amine derivative and positioned between the first electrode and the first emitting material layer; and a first hole blocking layer including a first hole blocking material of an azine derivative and positioned between the second electrode and the first emitting material layer, wherein the first host is an anthracene derivative, and the second host is a deuterated anthracene derivative.

The present invention relates to herbicidal compositions comprising at least one compound of formula (I) wherein the variables are defined as given in the specification, and at least one further active compound selected from herbicides of classes b1) to b15) and safeners C.