491 results about "High sensitive" patented technology

A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a pMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.

This present invention relates to a fluorescence endoscope apparatus, developed for diagnosing various illnesses within a body, especially for diagnosing a tumor inflamed region; and an application method of the same. The purpose of this invention is to enhance the accuracy of the examination. The fluorescence light endoscope apparatus in accordance with the present invention is comprised of an endoscope probe; a multiple light source that provides illumination light or excitation light of short wavelength onto a diagnostic region; a color CCD camera and a high sensitive monochromatic CCD camera placed on the back of an endoscope ocular lens; a reference test sample; a computer; and a monitor. The method of the present invention embodies a preliminary correction of the fluorescence endoscope apparatus of the present invention in accordance with the reference test sample; a general endoscopy using the illumination light, and an image observation and examination of the same diagnostic region using the fluorescence light and the reflected excitation light simultaneously; an auto-correction of brightness and unevenness of the fluorescence light images of the diagnostic region according to the reference test sample data; an evaluation of the brightness of the fluorescence light in the diagnosis region; storing numerical data that characterizing images and brightness of the fluorescence light in the diagnosis region; and storing image collected via two cameras as digital video clips.

The invention relates to a method to construct ordered structure on base, and the application of using the base to construct metal ordered structure. The method includes the following steps: adopting inorganic base or polymer base, taking base surface process to make it could conduct electricity, construct ordered microstructure of different functional group or macromolecule barrier layer; assembling the metal nanometer particle into the ordered structure to gain metal nanometer ordered structure. The invention could be widely used in making high sensitive metal sensor and detector.

The invention discloses a pipe leakage detecting system, comprising a controller and a pipe leak detector, wherein, the controller processes and store data in the pipe leak detector through a wireless technology; the pipe leak detector also comprises a sensor, an amplifier, an analog-digital conversion module, a main processor, a GPS clock synchronization control module, a wireless communication module and a power supply module, wherein, the sensor is arranged on a pipe to be detected; the amplifier is connected with the sensor; the analog-digital conversion module is connected with the amplifier; the main processor is connected with the analog-digital conversion module; the GPS clock synchronization control module is connected with the main processor; the wireless communication module is connected with the main processor; and the power supply module is connected with the main processor. In the invention, sensors are arranged on the outer wall of the pipe at intervals and receive sound waves produced by leakage points on the pipe under the condition that GPS time service error is less than 200nS, thereby realizing high sensitive detection of the pipe leakage and high precise positioning of leakage sources. In addition, the pipe leakage detecting system is characterized by low cost, small volume, light weight, being portable and convenient operation.

A magnetic sensor reduces thermal fluctuation and realizes high-sensitive signal detection using a spin Hall device of a simple structure configured with only one magnetic layer. The magnetic sensor includes a stacked film in which a nonmagnetic spin Hall layer, a nonmagnetic insulator layer, and a magnetic layer are stacked, an electrode nonmagnetic terminal pair connected to a side surface of the nonmagnetic spin Hall layer, and a unit applying a current in a film thickness direction of the stacked film. A thickness of the nonmagnetic spin Hall layer is thinner than twice a spin diffusion length of a material constituting the nonmagnetic spin Hall layer. A magnetization direction of the magnetic layer magnetized by an external magnetic field is detected due to the polarity of a voltage across both ends of the electrode nonmagnetic terminal pair.

The invention provides a method for manufacturing and integrating a multichannel high-sensitive biosensor. The method comprises the following steps: firstly, based on an SOI silicon chip, adopting a top-down method to manufacture an FET field effect transistor of a silicon nanometer wire; secondly, utilizing polydimethylsiloxane (PDMS) to manufacture a plurality of microfluid channels; and finally, modifying the silicon nanometer wires in different microfluid channels to allow the silicon nanometer wire to be modified with different detecting antibodies and small molecules for detecting different target molecules. The sensor manufacture by the method can be used for simultaneously detecting relevant factors (such as DNA, RNA, protein and the like) or virus of different types of diseases and has the characteristics of high sensitivity, stability, easy integration and the like.

The present disclosure relates to a fusion nano liposome-fluorescence labeled nucleic acid in which a bead having a surface binding with a branch-shaped nucleic acid structure labeled with a fluorophore or a branch-shaped nucleic acid structure having a hairpin loop end is included in an inside of a liposome, and a diagnosis application thereof. The fusion nano liposome-fluorescence labeled nucleic acid, or fusion nano liposome-fluorescence labeled hairpin loop structured nucleic acid may sense an external or internal signal, and high-sensitive diagnosis is possible even when mRNA and miRNA which is present at a low concentration in cells being targeted. Further, various target materials expressed inside and outside of a cell membrane may be targeted, and thus even a type of cancer which is hard to diagnose such as triple negative breast cancer also be flexibly diagnosed. Further, using various fluorophores, multiple cancer may be diagnosed at the same time.

There are provided a biochip and a biochip kit, in which a target contained in an analyte is reacted with a probe with high efficiency in a short time, B / F separation efficiency is high, and high-sensitive quantitative determination and detection can be realized, and a production process thereof, and a method for reacting a target contained in an analyte with a probe, and, for example, separation and fractionation method and a detection and identification method for a target contained in an analyte, using the biochip kit. The biochip according to the present invention comprises a well(s) provided with a filter comprising straight pores, with a uniform pore diameter, provided at uniform pore spacings. A dispersion with probe-supported particles dispersed therein is contained in the well, and an analyte is placed in the well(s) to react the analyte with the probe-supported particles. A solution such as an analyte solution can be introduced into or discharged from the well through the filter.

In a pattern inspection apparatus, influences of pattern brightness variations that is caused in association with, for example, a film thickness difference or a pattern width variation can be reduced, high sensitive pattern inspection can be implemented, and a variety of defects can be detected. Thereby, the pattern inspection apparatus adaptable to a broad range of processing steps is realized. In order to realize this, the pattern inspection apparatus of the present invention performs comparison between images of regions corresponding to patterns formed to be same patterns, thereby determining mismatch portions across the images to be defects. The apparatus includes multiple sensors capable of synchronously acquiring images of shiftable multiple detection systems different from one another, and an image comparator section corresponding thereto. In addition, the apparatus includes means of detecting a statistical offset value from the feature amount to be a defect, thereby enabling the defect to be properly detected even when a brightness difference is occurring in association with film a thickness difference in a wafer.

A shipping box (1) for shipping of high-value, highly sensitive objects, especially framed paintings, or painting stabilized in terms of shape in some other way, has a frame having side walls (3), a bottom wall (4) and a top wall (5) which forms a cover, and can be completely sealed, the walls of the shipping box (1) being lined with vacuum insulation panels (6).

The invention provides a whispering gallery mode photonic device and a preparation method thereof. According to the preparation method of a micro ring array structure, solvent droplets are utilized to dissolve a polymer film, so that a "coffee ring effect" can be generated, and therefore, polymer can be accumulated at the periphery of liquid so as to form an annular structure of which the height is obviously different from the height of the film, and conduction and confinement of light in the polymer structure can be realized; and light signals are inputted to the micron ring structure through utilizing excitation, scattering or near field coupling modes, so that a resonance effect in a whispering gallery mode can be realized. The prepared micron ring structure can be adopted as a high-quality factor optical micro cavity, so that a modulation-mode spectrum can be obtained, the width of spectral lines of the spectrum being significantly narrowed; a whispering gallery-mode light amplification stimulated emission can be realized through optical gain; and in a multi-ring coupled array structure, light signal processing and high sensitive response to outside stimuli can be realized according to the wavelength change information of the modulated spectrum and laser modes.

According to an aspect of an embodiment, a high-sensitive resistance measuring device of solder bumps comprises a resistance variation detection unit which detects a differential voltage (□V=V1−V2), which is obtained by subtracting a second voltage (V2) generated in a reference bump connection unit by a constant current (I) from a second constant current source from a first voltage (V1) generated in a monitored bump connection unit by the constant current I from a first constant current source, as a resistance variation voltage representing a resistance variation (□R) of the monitored bump connection unit.

A magnetic sensor reduces thermal fluctuation and realizes high-sensitive signal detection using a spin Hall device of a simple structure configured with only one magnetic layer. The magnetic sensor includes a stacked film in which a nonmagnetic spin Hall layer, a nonmagnetic insulator layer, and a magnetic layer are stacked, an electrode nonmagnetic terminal pair connected to a side surface of the nonmagnetic spin Hall layer, and a unit applying a current in a film thickness direction of the stacked film. A thickness of the nonmagnetic spin Hall layer is thinner than twice a spin diffusion length of a material constituting the nonmagnetic spin Hall layer. A magnetization direction of the magnetic layer magnetized by an external magnetic field is detected due to the polarity of a voltage across both ends of the electrode nonmagnetic terminal pair.

An image processing apparatus and method for generating high-sensitive, high-brightness color images are disclosed. A second image having a wider band and higher-sensitivity than those of a first image which includes color information may be acquired, wherein the first and second images are images captured from a scene. A first transformed image having high brightness may be generated by performing binning on the first image, and edge information being a high-frequency component may be extracted from the second image. A high-brightness, high-sensitive color image may be generated using the first transformed image and the edge information.

Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

The invention relates to an automatic monitoring method and system for long distance pipeline safety. It uses the monomode optical fiber laid near the distant pipeline, or the backup monomode optical fiber in the measured cable as sensing element; when the pipeline has leakage or the pipeline is damaged, the transmission character of the optical fiber will be changed, the light path difference of the laser in the two fibers will be changed; the change can be acquired with light interference method; at the same time, uses the affection of exterior force to the monomode optical fiber, and locating the position of the exterior on the pipeline. The several monitoring systems can be assembled into a network, thus the high sensitive, remote, real-time and automatic monitor to the long distance pipeline can be realized.

A cantilever beam structural resonant-type integrated optical waveguide accelerometer, includes an input waveguide (1), a dissymmetrical structural Mach-Zehnder interferometer (2), a micro-mechanical vibration cantilever beam (3), a short curved waveguide (4) and an output waveguide (5); all the waveguide structures and the cantilever beam use the integrated optical micromachining technique, and the device single-scale integration can be realized by using the temperature-insensitive organic polymer optical waveguide structure and the organic polymer substrate, the key technique indexes such as detection sensitivity, dynamic range are extensively adjusted. The phase difference of the optical signal can be measured by detecting the optical intensity of the resonant frequency of the optical circuit so as to achieve high sensitive acceleration detection, and to be free from the effect of the ambient temperature disturbance and waveguide birefringence.

The invention discloses a microfluidic microbead array chip and application thereof in virus analysis, and belongs to the field of biological application of a miniaturized total analysis system. The microfluidic microbead array chip consists of a microbead fixed microstructure array, a microbead transport channel, a reagent transport channel and a microstructure array coverage channel. When high-sensitive virus analysis is performed, virus molecules in a serum sample is prepared into a biotin doped target RNA sequence through PCR and in vitro transcription process, and flows to a testing areaof the chip to react with a functional microbead array; function modified microspheres can specifically identify and capture target sequences; a quantum dot labeled reagent are introduced; surfaces of micro-particles are combined with quantum dots because of specifically capturing; and detection and quantitation are performed by a fluorescence imaging method. The microfluidic microbead array chipprovided by the invention has the advantages of simple process, high detecting sensitivity and quick detection, and provides an effective studying and detecting means for high-sensitive virus analysis.

Piezoelectric crystal elements are provided having preferred cut directions that optimize the shear mode piezoelectric properties. In the discovered cut directions, the crystal elements have super-high piezoelectric performance with d15, d24 and d36 shear modes at room temperature. The d15 shear mode crystal gives a maximum d value and is free from the cross-talk of d11 and d16. The d36 mode is extremely reliable compared to other shear elements due to its ready re-poling capability. The crystal elements may be beneficially used for high-sensitive acoustic transducers.

A CCD of a digital camera has high sensitive main pixels for depicting gradations in low and middle brightness portions of a subject, and low sensitive sub pixels for depicting gradations in high brightness portions of the subject. Main pixel image signals from the main pixels have a larger signal level than sub pixel image signals from the sub pixels. The main pixel image signals are attenuated by an attenuator to have the same signal level as the sub pixel image signals. The attenuated main pixel image signals and the sub pixel image signals are amplified by an amplifier with the same gain. The amplified main and sub pixel image signals are digitalized and composed to generate composite image data.

A system and method are provided for detecting biological and chemical material. To measure biological materials such as genes easily at low costs, the device for implementing a small-sized, high sensitive, economical measurement apparatus is provided. Probes appropriate for target biological materials are fixed on a chip, on which a sensor, identification number, and radio communication function are implemented, the captured targets are detected by the sensors, and the result of sensing are transferred to an external control unit by the radio communication function. The small-sized, high sensitivity measurement apparatus for detecting biological and chemical materials such as genes and measuring physical and chemical amounts such as temperature, pressure, pH, and the like can be implemented.

This invention provides a high sensitivity and multi-position collision detection method which installs a multi-position collision sensor, said sensor consists a closed cavity with insulation gap, the shape variable conductive inertia body is filled in cavity, contacts are set in gap and leading line to outer of casing to be used as electrode which is switched on when the inertia body change shape and is crowed into gap under external force, and switched off when the shape is restored. Said method can detect multi-position and high sensitive collision signal and can be used in many kinds of collision.

The invention relates to a novel intelligent bra for early detection of breast cancer. The intelligent bra carries ultra-high sensitive computer micro-processing chips, which include temperature sensor, blood flow sensors, oxyhemoglobin quantity sensors and the like for all-round acquisition of breast tissue temperature, blood flow and the hemoglobin amount. The device saves periodically collected data in a computer through a wireless transmission system, and automatically analyzes and alarms whether carcinogenesis possibility exists in breasts.

The invention relates to a group of anti-human CD146 molecules which are developed by utilizing the biological technology and an established high-sensitive sandwich ELISA method for detecting the solubility CD146. The invention includes anti-human CD146 mouse monoclonal antibodies of AA1, AA2, AA3, AA4, AA5 and AA7, and the method of utilizing the combination of the antibodies and the sandwich ELISA specificity for detecting the solubility CD146. The group of antibodies can identify the human source CD146 on the molecular, the cellular and the tissue levels, which can be divided into two categories based on the identified different epitopes. The sandwich ELISA method which is combined by the antibody AA1 and another strain of anti-human CD146 mouse monoclonal antibody AA98 can detect the solubility CD146 at each milliliter nano-gram level. The antibodies and the detection means can become the effective detection or diagnosis tools and method in the basic research or the clinical application and provide good carriers for the targeted therapy of the CD146-related diseases at the same time.

A high sensitive measuring method of sensing device with multichannel fibre optics grating includes converting displacement, pressure and vibration signal measured by FBG transducer to be Bragg wavelength; carrying out scanning on designed spectrum with tunable filter and recording photoelectric detector output; confirming midpoint of waveform rising or falling edge according to spectrum waveform and using it as working point; carrying out real time measurement by tuning tunable filter center wavelength to working point of each FBG transducer in sequence correspondingly.

The invention relates to a spectral pupil laser differential confocal LIBS, a Raman spectrum-mass spectrum microscopic imaging method and a Raman spectrum-mass spectrum microscopic imaging device and belongs to the technical fields of confocal microscopic imaging, optical-spectrum imaging and mass spectrum imaging. In the invention, spectral pupil laser differential confocal imaging is combined with optical-spectrum and mass spectrum detection technologies, so that high-spatial-discrimination form imaging to a sample is carried out by means of a micro focus light spot of a spectral pupil laser differential confocal microscope which is subjected to ultra-discrimination technology treatment; mass spectrum detection to charged molecules and atoms in a micro zone of a sample is carried out by means of the mass spectrum detection system; micro zone optical spectrum detection is carried out to a focused light spot excitation spectrum (Raman spectrum, induced breakdown spectrum) of the spectral pupil laser differential confocal microscopic system through the optical-spectrum detection system; and high-spatial discrimination, high-sensitive imaging and high-sensitive detection to complete component information and form parameters of the sample micro zone is carried out through advantage complement and structural fusion of laser multi-spectrum detection. The invention provides a novel technical approach for imaging detection of substance components and formations in the field of biology, material and the like.

The invention discloses a preparation method of molecularly imprinted polymeric microspheres for 2,4,6-trinitrophenol detection. The preparation method is characterized in that polynitrophenol derivatives-imprinted molecules generated through reaction between 2,4,6-trinitrophenol and N,N'-diisopropyl carbodiimide have luminous yellow fluorescent light, the fluorescent light of the imprinted molecules has open and close characteristics under an acid-base condition, the imprinted molecules located in an imprinting layer of the molecularly imprinted polymeric microspheres can be eluted, a hole structure which is complementary with the structure, the size and the functional groups of the imprinted molecules is formed in the imprinting layer, polymeric microspheres of which the imprinted molecules are eluted have specific recognition sites on target analyte molecules, target molecules enter the specific recognition sites, selective recognition on the target analyte molecules is realized, sensitivity detection of the target analyte molecules can be realized through opening and closing of the fluorescent light of the target molecules, the specific surface area of the molecularly imprintedmicrospheres is large, and space in which the recognition sites are formed is stable in structure, has more effective sites, and is capable of carrying out high-selective recognition and high-sensitive detection on the target molecules.

A magnetism fluorescence composite mainly consists of modified magnetism crystal material, modified fluorescent semiconductor crystal material and matrix material; among them modified magnetism crystal material uses silylating reagent partaking -NH2, -C=C, -SH, -S-S or epoxy group; modified fluorescent semiconductor crystal material uses Reactive surfactant. The composite of this invention not only has excellent fluorescence property but also has conspicuous magnetic response property, its merit is not only fluorescent nanometer crystal and magnetism nanometer particle link with basis material possessing tight Structure through chemical bond, but also the integration of fluorescence and magnetism provides new application for high sensitive bioanalysis and detection.

The invention discloses a high sensitive biochemical sensor based on a resonance oscillation type micro cantilever beam structure. The biochemical sensor comprises a resonance oscillation chamber, a cantilever beam and a Whist bridge type detection circuit, wherein a micro column structure (3), a liquid storage tank (4) and a liquid leakage hole (5) through which biochemical solution flows are etched at the free end of the cantilever beam; the support end of the cantilever beam is connected with the Whist bridge type detection circuit; the Whist bridge type detection circuit is composed four U-shaped piezoresistance bars (1), three input electrodes (8, 9, 10) and two output electrodes (7, 11); and the four piezoresistance bars (1) are connected with the input electrodes (8, 9, 10) and the output electrodes (7, 11) through a signal transmission line (2). With the adoption of the biochemical sensor, micro biochemical molecules can be sensed with a high sensitivity by detecting the frequency change after an object to be tested is absorbed; biochemical molecules with micromass can be detected; and the biochemical sensor can be widely used in engineering fields such as medicine and chemistry.