44 results about "Targeted interventions" patented technology

Embodiments of an instrument manipulator are disclosed. An instrument manipulator can include a track; a translational carriage coupled to ride along the track; a shoulder yaw joint coupled to the translational carriage; a shoulder pitch joint coupled to the shoulder yaw joint, the shoulder pith joint including an arm, a wrist mount coupled to the arm, struts coupled between the wrist mount and the shoulder yaw joint, and a shoulder pitch mechanism coupled to the arm; a yaw-pitch-roll wrist coupled to the wrist mount, the yaw-pitch-roll wrist including a yaw joint and a differentially driven pitch-roll joint; and an instrument mount coupled to the wrist. The various joints and carriages can be driven by motors.

The invention provides an antisense RNA sequence combination and application thereof in production of abortive tilapia, and belongs to molecular biology and breeding biology technologies. The antisense RNA sequence combination comprises antisense RNA of steroid-producing factors SF1-1 and SF1-2; and nucleotide sequences of Anti-SF1-1-II, Anti-SF1-2-I and Anti-SF1-2-II are respectively shown as SEQID No. 1 to SEQ ID No. 4. According to the method, an antisense RNA fragment is introduced into an ovum through a fertilization hole, so that effective and accurate targeted intervention is realizedto regulate expression of genes; and the method is simple to operate, extremely small in ovum damage, high in success rate and stable in representative type after breeding, and has extremely strong application prospect.

The invention provides a real-time monitoring and control system for university classroom teaching effect based on classroom multimedia equipment, including a main controller, a sub-controller, a seat identification device and a seat state detection device, including only one main controller, each seat needs Correspondingly configure a sub-controller, a seat recognition device and a seat state detection device, the face camera of the seat recognition device regularly collects face images, and the high-precision camera of the seat state detection device periodically collects images. collection. The invention is expected to help teachers easily and conveniently monitor the learning status of college students in the classroom, and carry out targeted intervention in a timely manner, which protects the self-esteem of students to the greatest extent, makes college students more willing to accept such supervision, and helps college students improve classroom learning. Proactivity and self-monitoring.

The invention discloses application of a transcription factor ZEB1 for preparing a medicine capable of accelerating breast cancer chemosensitivity. The transcription factor ZEB1 can mediate the chemotherapy resistance of the breast cancer, and the breast cancer chemosensitivity can be improved through the targeted intervention of the ZEB1. On one hand, the ZEB1 can accelerate the breast cancer chemotherapy resistance through a way of accelerating DNA (Deoxyribose Nucleic Acid) damage repair, and the generation of the chemotherapy resistance is realized through the regulation and the control on ATM (Ataxia Telangiectasia-Mutated Gene) by the ZEB1. On the other hand, the ZEB1, P300 and / or PCAF (P300 / CBP-Associated Factor) can form a compound, wherein the compound performs a regulation and control function on the ATM. Meanwhile, a ZEB1-shRNA lentivirus gene knock-down system is used for verifying the function of Le-shZEB1 in enhancing the anti-tumor curative effect of anti-tumor medicines through breast carcinoma cell lines and an in vivo nude mouse model, and the tolerance problem of the breast cancer on chemotherapy is effectively solved. The invention provides a new target spot and a therapeutic strategy for alleviating the chemotherapy resistance of the breast cancer, increasing the sensitivity of chemotherapy medicines and the like.

The invention discloses a preparation method of an AAV9-CIP virus of expressed neurodegenerative disease protection peptide. The preparation method comprises the following steps that 1, a Myc-CIP primer is designed, and Myc-CIP gene segments are obtained; 2, plasmid pCR2.1-Myc-CIP is obtained; 3, plasmid pEGFP-C2-Myc-CIP is obtained; 4, plasmid pAAV-hSynapsin-GFP-Myc-CIP is obtained; 5, the AAV9-CIP virus is obtained. The invention aims at providing the AAV9-CIP virus, capable of being specifically expressed in central nervous system neuron, of neurodegenerative disease protection peptide. Due to the fact that a neurotoxic compound CDK5 / p25 generated in the lesion process of the nervous system neurodegenerative disease can be specifically inhibited by CIP, the CIP virus capable of being used for targeted intervention treatment of the nervous system neurodegenerative disease, such as the Alzheimer's disease and Parkinson's disease is established.