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45 results about "Intervention treatment" patented technology

An intervention is a carefully planned process where family, friends and others involved in the person’s life gather together to tell the person about the effect of their addiction and ask him or her to accept treatment. The intervention usually offers a prearranged treatment action plan with clear steps,...

AI-based atrial fibrillation patient health risk prediction method

ActiveCN121506507AMedical data miningHealth-index calculationHealth riskIntervention treatment
The invention discloses an AI-based atrial fibrillation patient health risk prediction method, and belongs to the technical field of medical information, and the method specifically comprises the steps: receiving a physiological parameter record and an intervention treatment record of an atrial fibrillation patient, carrying out the time sequence alignment operation, and forming structured patient data; extracting risk-related features from the structured patient data, wherein the risk-related features are divided into basic risk features and intervention response features; inputting the basic risk features into a basic risk prediction network, and outputting a basic risk score; inputting the intervention response characteristics and the basic risk score into an intervention effect separation network together to generate a post-intervention risk score; calculating a net effect value of treatment intervention according to the difference between the basic risk score and the post-intervention risk score; combining the basic risk score, the post-intervention risk score and the net effect value to generate a patient individualized long-term risk prediction trajectory; and accurate prediction of the long-term health risk of the atrial fibrillation patient is realized.
Owner:FUJIAN PROVINCIAL HOSPITAL

Cardiovascular patient group health assessment system based on diet and individual characteristics

The invention relates to the technical field of cardiovascular disease health risk assessment and management, and discloses a cardiovascular patient group health assessment system based on diet and individual characteristics, which comprises a data acquisition module, an analysis and prediction module and a health assessment module. According to the cardiovascular patient group health assessment system based on diet and individual characteristics, a data acquisition module acquires a user data set, a data preprocessing unit identifies the user data set, a risk proportion unit calculates a disease risk ratio Hbfx, and a variable prediction unit calculates a disease prediction data set Fbyc; the health assessment module calculates a comprehensive influence data set Zhyx and comprehensively assesses the influence of significant variables of a user on CVD risks, analysis and assessment are more comprehensive and highly targeted, the health assessment module compares a reference data set according to the comprehensive influence data set Zhyx and judges and assesses corresponding scores, and the effect of early intervention and treatment of cardiovascular diseases is better.
Owner:ZHEJIANG QINGKAI FOOD & HEALTH TECH CO LTD +1

Speech disorder detection method, device, equipment and readable storage medium

ActiveCN120318639BCharacter and pattern recognitionSensorsSpeech disorderSpeech sounds
The present disclosure relates to a speech disorder detection method, device, equipment and readable storage medium. By acquiring standard audio-visual materials, in response to the pronunciation operation of the to-be-detected object to the standard audio-visual materials, multi-modal pronunciation data is collected, audio acoustic features are extracted based on the pronunciation audio, video visual features are extracted based on the video of the face and oral cavity activity, the audio acoustic features, the video visual features and the demographic information coding data are fused to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, a speech disorder detection result of the to-be-detected object is obtained. Compared with the prior art, the embodiment of the present disclosure can improve the accuracy and comprehensiveness of speech disorder detection, improve the diagnosis efficiency, reduce the dependence on professionals, reduce the burden of medical resources, and clearly determine the specific type of pronunciation problem, thereby providing a scientific basis for subsequent individualized intervention treatment.
Owner:AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS

Clinical interventional therapy catheter fixing device for department of cardiology

The invention relates to the technical field of catheter fixing devices. The cardiology department clinical interventional therapy catheter fixing device comprises a binding assembly, a first connecting assembly is installed at one end of the binding assembly, a second connecting assembly is installed at the other end of the binding assembly, a limiting assembly is installed at the top of the binding assembly, and a fixing assembly is installed at the top of the binding assembly. The limiting assembly is connected with the fixing assembly and limits the fixing assembly. A binding bandage is bound on the body of a patient, a second fixing shaft slides into clamping grooves in two clamping arms, the second fixing shaft is fixed through the clamping grooves under the torsion action of a first torsion spring, and limiting plates on the inner sides of the clamping grooves can be clamped into limiting grooves in the outer wall of the second fixing shaft, so that the second fixing shaft is fixed. The friction force between the binding bandage and the skin of the patient can be increased through the multiple rubber sheets on the rubber belts at the two ends of the binding bandage, and therefore the installation stability of the binding bandage can be improved.
Owner:CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL HAINAN HOSPITAL

A method and system for risk stratification of chronic coronary syndrome based on coronary microcirculatory resistance index

PendingCN122455361AVery low riskCoronary arteries
The application discloses a kind of chronic coronary syndrome risk stratification methods based on coronary microcirculation resistance index, it is related to medical data processing technical field.The method comprises: the clinical characteristic data of patient to be evaluated is obtained;The clinical characteristic data is input into the preset risk stratification model, and the risk group of the patient to be evaluated is obtained according to preset split condition.The preset split condition determines the split priority by analyzing the nonlinear correlation and the degree of distinction of multidimensional feature data, and generates a multi-layer classification model by combining survival tree algorithm training.The application breaks through the limitation of single index evaluation, effectively captures the nonlinear interaction between clinical indicators, significantly improves the risk stratification accuracy, can accurately identify the very low risk and high-risk subgroup, avoid clinical over-treatment or insufficient intervention treatment, and the model has strong interpretability and is easy to promote clinically.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Efficacy evaluation and remote follow-up platform for ultrasound intervention treatment of mastitis

ActiveCN121565361BReal-time synchronizationavoid identifyingMedical data miningPatient-specific dataPatient dataMastitis
The present application relates to the field of medical informatization and remote diagnosis and treatment technology, and discloses a curative effect evaluation and remote follow-up platform for mammitis ultrasonic interventional treatment. The platform integrates the imageological changes, physiological parameter trajectories, operation records and follow-up feedback of patients through a data processing module. A window recognition module dynamically divides curative effect observation windows and conventional observation windows according to treatment and feedback time points. A patient clustering module clusters patients based on the timing mode of physiology and images within the curative effect window, and identifies different response modes. A feature extraction module extracts typical operation features and follow-up response baselines of each patient community accordingly. A strategy generation module calculates the multidimensional matching degree by matching new patient data with the feature baselines of each community, and generates individualized follow-up strategies, thereby realizing adaptive and accurate definition of the curative effect evaluation window and individualized and directional optimization of follow-up management.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Preparation and application of kidney dual-targeting black phosphorus nano platform for treating acute kidney injury

PendingCN121513217AOrganic active ingredientsPowder deliveryMalignant progressionInjection solution
The invention provides preparation and application of a kidney dual-targeting black phosphorus nano platform for treating acute kidney injury. Firstly, black phosphorus nanosheets and NH2-PEG-NH2 are mixed and then dispersed into deionized water, centrifugation is repeated, supernate is discarded, and a BP-PEG solution is obtained; kim-1 targeted polypeptide LTH powder is dissolved in deionized water, then EDC and NHS are added for a light-shielding reaction, a BP-PEG solution is added, light-shielding stirring is continued to obtain a BP-PEG-LTH mixture, then 4-octyl itaconic acid is added, then a PBS solution is added, light-shielding magnetic stirring is carried out, and the kidney double-targeting black phosphorus nano platform is obtained. The kidney dual-targeting black phosphorus nano platform is used as an intravenous injection for treating acute kidney injury, oxidative stress can be rapidly and effectively inhibited, inflammation is resisted, intercellular burial is promoted, malignant development of AKI is inhibited to a great extent, and the purpose of short-term specific intervention treatment after AKI is achieved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Application of hederagenin in preparation of medicine for maintaining dryness of ATII

The invention discloses a novel application of hederagenin in preparation of a medicine for maintaining the dryness of alveolar II epithelial cells, the hederagenin is definitely used for preparing the medicine for maintaining the dryness of the alveolar II epithelial cells for the first time, and the repairing effect of the hederagenin on ATII dry damage is verified through in-vivo and in-vitro experiments. A brand new treatment strategy is provided for lung diseases such as acute lung injury, pulmonary fibrosis and the like which are characterized by ATII dry failure, the technical blank of intervention of natural active ingredients in ATII dry is filled up, a new way which is efficient, low in cost and easy to obtain is provided for ATII dry maintenance, the concentration of a medicine prepared from the natural active ingredients is screened, and the clinical application prospect is wide. An important theoretical basis is provided for further medication and medicine preparation, meanwhile, the pharmacological application range of the hederagenin is expanded, and a new target and a new strategy are provided for subsequent intervention treatment of lung diseases such as acute lung injury and pulmonary fibrosis needing injury repair.
Owner:GANSU UNIV OF CHINESE MEDICINE

Precise pushing equipment for bronchial intervention medicine

The invention relates to the field of bronchial interventional therapy, in particular to bronchial interventional medicine accurate pushing equipment which comprises a lantern ring sealing tile, a hinge part is arranged on one side of the outer arc face of the lantern ring sealing tile, and the lantern ring sealing tile is connected with an annular base disc through the hinge part of the outer arc face. A deformation cavity of the built-in guide sleeve is filled with the outer arc face of the medicine storage bag and tightly attached to the inner inclined end, a contact face gap is filled with a reserved cavity of the elastic blocking piece, and the sealing gasket is extruded through cooperation with the fastening nut to form port sealing. In the dosing process, a clamping structure of a conical clamping block and an external guide sleeve is combined with a hinged fixed elastic blocking piece of an annular base disc of a lantern ring sealing tile to synchronously reinforce sealing of a contact surface, so that liquid medicine is effectively prevented from being stored; a leakage path in the pushing and resetting process not only avoids medicine dosage loss and ensures that the medicine amount delivered to a lesion area reaches an expected treatment standard, but also prevents local stimulation or adverse reaction caused by the fact that leaked liquid medicine makes contact with normal tissues of the bronchial tube, and the treatment risk of a patient is reduced.
Owner:LONGGANG DISTRICT CENT HOSPITAL OF SHENZHEN

Application of 4-VPS in preparation of kit for screening and / or diagnosing hypertensive kidney injury

PendingCN121805570AComponent separationMicrobiological testing/measurementEnd-stage kidney diseaseHypertensive Nephropathy
The invention relates to the technical field of biological medicine, in particular to application of 4-VPS in preparation of a kit for screening and / or diagnosing hypertensive kidney injury. According to the invention, a detection sample of 4-VPS is peripheral blood, and the sample is convenient to collect, minimally invasive and easy to popularize clinically; meanwhile, functional experiments prove that 4-VPS can directly induce kidney injury, early diagnosis of hypertensive nephropathy is achieved through 4-VPS, a patient can receive intervention treatment in the early stage of the disease, the disease is delayed or even prevented from developing into the end-stage nephropathy, the requirement of the patient for subsequent dialysis treatment or kidney transplantation is reduced, personal medical expenditure is reduced, and the treatment cost is reduced. Meanwhile, consumption of social medical resources is reduced, and remarkable economic benefits are achieved.
Owner:SHANGHAI UNIV OF MEDICINE & HEALTH SCI

Interventional method, device, electronic device and storage medium for deep brain stimulation

The application provides an intervention method, device, electronic equipment and storage medium for deep brain stimulation, wherein the intervention method comprises: acquiring an electroencephalogram signal of a target user, determining an electroencephalogram feature set of the electroencephalogram signal, determining intervention-related information for the target user based on the electroencephalogram feature set, and performing intervention processing according to the intervention-related information. In this way, when the DBS intervention is performed, the intervention-related information suitable for the patient's disease condition can be automatically selected according to the electroencephalogram feature of the patient, so that the effect of precise intervention treatment is achieved.
Owner:BEIJING NAOLU TECH CO LTD

Use of levosimendan in the preparation of a medicament for the treatment of pulmonary arterial hypertension

The application provides application of levosulpiride in preparation of a medicine for treating pulmonary arterial hypertension, and the medicine comprises levosulpiride as an active ingredient. Through a pulmonary arterial hypertension model of a rat, the application gives an intervention treatment of levosulpiride, and the effect of levosulpiride on pulmonary vessels is determined: the levosulpiride can reduce the mean pulmonary arterial pressure of a pulmonary arterial hypertension rat, reduce pulmonary vascular resistance, and improve right ventricle and pulmonary vessel remodeling, thereby providing a strategy for developing the medicine for treating the pulmonary arterial hypertension.
Owner:SHANGHAI PULMONARY HOSPITAL (SHANGHAI OCCUPATIONAL DISEASE PREVENTION & CONTROL INSTITUTE)

Percutaneous liver puncture biliary drainage auxiliary device for tumor clinical interventional therapy

PendingCN121868599AMedical devicesCatheterInterventional oncologyIntervention treatment
The invention discloses a tumor clinical interventional therapy percutaneous liver puncture biliary drainage auxiliary device, comprising: a clamping protection mechanism comprising a clamping frame assembly and a gooseneck assembly which is arranged on the clamping frame assembly and can be adjusted in position along the vertical direction; the complication monitoring assembly comprises a monitoring host installed on the clamping frame assembly, and a temperature sensor and an ultrasonic flow sensor which are electrically connected with the monitoring host; the temperature sensor is used for monitoring the body temperature of a patient in real time, and the ultrasonic flow sensor is connected with the drainage tube and used for achieving non-invasive monitoring of the bile flow velocity; the binding belt assembly is used for being fixed to the waist and abdomen of a patient in a surrounding mode, and the binding belt assembly is provided with a first through hole used for a drainage tube to pass through and a second through hole used for a temperature probe of a temperature sensor to pass through; the problems that an existing percutaneous liver puncture biliary tract drainage auxiliary device is poor in drainage tube protection effect and insufficient in complication risk monitoring capacity are solved.
Owner:SHIJIAZHUANG PEOPLES HOSPITAL

Application of arginine vasopressin in treatment of slow transit constipation

The invention discloses application of arginine vasopressin in treatment of slow transit constipation, and relates to the technical field of medicines for treating slow transit constipation. The arginine vasopressin nose drop is found to have a very good treatment effect on slow transit constipation for the first time, and especially for loperamide-induced slow transit constipation, the arginine vasopressin nose drop can effectively promote intestinal tract movement and improve constipation symptoms. The arginine vasopressin is prepared into nose drops, can bypass a blood brain barrier to enter the brain, directly targets downstream nuclei of AVP neurons in a hypothalamic para-ventricular nucleus PVN nuclei, and intervenes treatment in the nerve center, and the effect is better. The discovery of the invention expands a new application for arginine vasopressin drugs, and also provides a new idea for development of constipation drugs.
Owner:WUHAN BAIYINGNUO MEDICAL TECHNOLOGY CO LTD

Human glioma DNA marker and its application

ActiveCN117778581BClinical prognosisNucleotide
The present application belongs to the technical field of biological medicine, and particularly relates to a human glioma DNA marker and application thereof. The marker comprises three DNAs, namely PBK, SPP1 and LTA, and the corresponding DNA nucleotide sequences are shown in SEQ ID NO. 1, SEQ ID NO. 2 and SEQ ID NO. 3, respectively. The present application provides a molecular marker for glioma prognosis prediction and application thereof. The transcriptome dataset of glioma patients is obtained by TCGA, CGGA-array and CGGA-seq datasets, and three gene markers are screened. Research shows that the three gene markers can independently predict the survival of glioma patients, and can be used as a reference index for judging the survival time of glioma prognosis and predicting the survival risk. By studying the relationship between the three gene markers and the clinical prognosis of glioma patients, a new marker is provided for the prognosis of glioma, so as to improve the timely intervention treatment of glioma patients and improve the clinical prognosis of patients. It has very important significance in clinical practice.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Method for improving freeze-thaw ovarian function by adopting mT-level pulsed magnetic field

The invention belongs to the field of bioelectromagnetism, and particularly discloses a method for improving functions of frozen and thawed ovarian tissues by adopting an mT-level pulsed magnetic field. According to the method, ovarian tissue which is subjected to vitrification freezing and resuscitation is exposed in a pulsed magnetic field with specific parameters for intervention treatment; wherein the intensity of the pulsed magnetic field is 5 mT, the current period is 1000-6000 [mu] s, the duty ratio is 50%, the pulse repetition number is 30, and the pulse interval is 60 ms. According to the application, a non-intrusive and drug-residue-free physical intervention means is adopted, inflammatory response can be effectively inhibited, oxidative stress injury can be relieved, the number of functional mitochondria is increased by up-regulating mitochondrial fusion genes (such as Mfn1 and Mfn2), the energy metabolism state of cells is fundamentally improved, the survival rate of transplanted ovarian tissue is remarkably increased, the functional life of the ovarian tissue is prolonged, and the survival rate of the ovarian tissue is increased. The method is simple to operate, low in cost and good in clinical application prospect.
Owner:HUAZHONG UNIV OF SCI & TECH

Intervention device for myopia and treatment method thereof

PendingCN121242831AElectrotherapyEye-masksIntervention treatmentContact layer
The invention relates to a myopia intervention device and a treatment method thereof. The myopia intervention device comprises a host and a replaceable intelligent eye pad connected with the host, the intelligent eye pad is designed to be of a multi-layer structure, and sequentially comprises a hydrogel contact layer used for being attached to the skin and conducting electricity from the contact eye skin to the inside; the iontophoresis layer is used for generating pulse current to drive nutrient substances in blood to directionally permeate to sclera tissues; the optical layer is used for emitting monochromatic light with different wavelengths to act on cells of the retina; the micro magnetic field layer is used for generating a micro magnetic field with specific form and strength; the host is used for controlling the iontophoresis electrode layer, the optical layer and the micro-magnetic field layer to work cooperatively according to a preset time sequence and performing intervention treatment on eyes; according to the technical scheme, the myopia intervention treatment effect can be improved.
Owner:LIUZHOU DINGYU INFORMATION TECHNOLOGY CO LTD

Targeted periprosthetic infection detection, drug delivery and drug intervention system and method and application thereof

PendingCN121313829AAntibacterial agentsEnergy modified materialsMicrococcal nucleaseDrug release
The invention discloses a targeted periprosthetic infection detection, drug delivery and drug intervention system as well as a method and application thereof, and belongs to the field of biological medicine. The detection and drug intervention system comprises a micrococcus nuclease sensitive biological probe, a functional silicon plastid for bearing the micrococcus nuclease sensitive biological probe, light-cured hydrogel and an implant, wherein medicines are carried in the functional silica plastid; a micrococcus nuclease sensitive biological probe is connected to the surface of a functional silicon plastid through electrostatic interaction force to obtain a nuclease probe functional silicon plastid, and the nuclease probe functional silicon plastid is connected to the surface of an implant through photocuring hydrogel. According to the system provided by the invention, the detection is realized, the delivery of the medicine is also realized, and the release of the medicine can also be realized when the occurrence of infection around the prosthesis is judged, so that the intervention treatment of the medicine is carried out.
Owner:SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)

Visual positioning device for pain interventional therapy under ultrasonic guidance

PendingCN121465695ADiagnosticsSurgical needlesIntervention treatmentPhysical therapy
The invention discloses a visual positioning device for pain interventional therapy under ultrasonic guidance, and relates to the technical field of auxiliary instruments for pain medical interventional therapy. The device comprises a support and a multi-joint arm, one end of the multi-joint arm is fixedly connected with the top end of the support, an ultrasonic probe fixing assembly and a treatment instrument guiding assembly are arranged at one end of the multi-joint arm, the ultrasonic probe fixing assembly comprises an ultrasonic probe fixing box, and an elastic piece and a clamping plate are arranged in the ultrasonic probe fixing box; the elastic piece and the clamping plate are used for clamping the ultrasonic probe in the ultrasonic probe fixing box, the treatment instrument guiding assembly comprises a fixing pipe and a depth limiting pipe, and stable fixing of the ultrasonic probe and precise guiding, depth adjusting and angle locking of a puncture needle can be achieved through the ultrasonic probe fixing assembly and the treatment instrument guiding assembly; positioning deviation caused by handheld operation is avoided, and the accuracy and safety of pain interventional therapy under ultrasonic guidance are improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV

Combination of bam-15 with erlotinib and products

PendingCN122351247AErlotinibAntagonism
This invention, entitled "Combined Application and Product of BAM-15 and Erlotinib," belongs to the field of combined antitumor drug application technology. The technical problem it aims to solve is the low response and limited efficacy of existing erlotinib monotherapy to EGFR wild-type lung adenocarcinoma, and the lack of effective targeted intervention options in clinical practice. The key points of the technical solution are: combining BAM-15 and erlotinib for the interventional treatment of EGFR wild-type lung adenocarcinoma; the combination produces a significant synergistic effect, with tumor suppression superior to the additive effect of using either drug alone, without antagonistic effects, effectively enhancing the inhibitory effect on EGFR wild-type lung adenocarcinoma and enriching clinical treatment options for tumors.
Owner:SANLY-HEALTH INC IN CELL-TECHNOLOGIES LTD BEIJING

An individualized health intervention method based on gut microbiota regulation

PendingCN122638038AMetabolitePhysiology
The application discloses an individualized health intervention method based on intestinal microbiota regulation, and generates a precise intervention scheme through machine learning and multi-omics data analysis; the method comprises the following steps: collecting intestinal microbiota, metabolite and short-chain fatty acid (SCFA) data, adopting a support vector machine (SVM), a random forest (RF) and a neural network (NN) model, constructing a flora-metabolism-phenotype causal model, and predicting an intervention effect; generating an individualized scheme such as exercise intensity, frequency, compound preparation dose and probiotic intake based on an optimization algorithm, and combining test to verify the effect; and dynamically adjusting the scheme according to follow-up data through a closed-loop updating mechanism. The method effectively improves metabolic dysfunction such as fatty liver disease and liver fibrosis, has high individualization, accuracy and implementability, and is suitable for intervention treatment of various diseases.
Owner:GUANGZHOU NATIVE INTELLIGENCE TECHNOLOGY CO LTD +1

An ultrasound intervention treatment carriage

The utility model relates to medical instrument technical field, concretely discloses a kind of ultrasonic intervention treatment bracket, comprising: support mechanism and bracket mechanism assembled on the support mechanism;The support mechanism includes clamping frame, and the one side of the clamping frame is fixedly installed with track frame, and the one side of the track frame is slidably installed with sliding sleeve;The bracket mechanism includes sliding column installed in the sliding sleeve, and the one side of the sliding column is rotatably installed with sleeve, and the one side of the sleeve is slidably installed with telescopic link, and the top of the telescopic link is rotatably installed with support rod, and the top of the support rod is hingedly connected with bracket seat, and the top of the bracket seat is provided with vent hole;The utility model can use bracket seat to support the arm of medical staff, can ventilate and drive heat to the skin of contact position, not prone to sweating and itching, effectively improve the comfortable effect when supporting the arm of medical staff.
Owner:HENGSHUI PEOPLES HOSPITAL (HARISON INT PEACE HOSPITAL)

KOA rehabilitation condition monitoring method based on intestinal flora and multi-source data collaboration

The invention provides a KOA rehabilitation condition monitoring method based on intestinal flora and multi-source data collaboration, and relates to the technical field of rehabilitation monitoring, the method comprises the following steps: screening KOA patients and healthy subjects, obtaining intestinal flora data, inflammatory factor data and electroencephalogram data, and obtaining electroencephalogram feature information; determining physiological state change information and rehabilitation condition information of the KOA patient in each treatment course, further determining an intervention effectiveness evaluation index, and obtaining a rehabilitation condition monitoring result. According to the method and the system, a healthy subject can be screened as a reference, and whether the physiological state of the KOA patient is changed or not and whether the KOA patient is rehabilitated or not is judged by monitoring intestinal flora, inflammatory factors and electroencephalogram data of the KOA patient, so that the rehabilitation condition of the KOA patient is accurately analyzed, and a plurality of KOA patients can be diagnosed based on the rehabilitation condition of the KOA patient. Whether the intervention treatment on the KOA patient is effective or not is determined, and an accurate data basis is provided for analysis of the intervention effect.
Owner:任毅 +1

Application of interleukin 33 antibody in preparation of medicine for relieving asthma exacerbation

The invention belongs to the technical field of biological medicines, and relates to application of an interleukin 33 antibody in preparation of a medicine for relieving asthma aggravation, in particular to application of the interleukin 33 antibody in preparation of a medicine for relieving asthma aggravation induced by ozone exposure. According to the application disclosed by the invention, comprehensive research experiments are adopted, the intervention treatment of the IL-33 antibody is implemented by constructing an asthma model and utilizing an ozone-induced asthma exacerbation model, and the pathophysiological action of the IL-33 antibody in relieving ozone-induced asthma exacerbation is comprehensively disclosed. Experimental results show that the IL-33 antibody can relieve the conditions of asthma mouse lung dysfunction, lung tissue inflammatory cell infiltration and immune cell imbalance in lung tissue caused by ozone exposure. The invention provides a new perspective for the treatment of asthma, and provides a scientific basis and practical value for developing a novel and effective asthma prevention and treatment strategy. The traditional Chinese medicine composition is expected to improve the living quality of asthma patients and reduce health risks caused by environmental pollutants, and has important clinical significance and social value.
Owner:FUDAN UNIVERSITY

Arm fixing device for coronary intervention treatment

The application relates to the technical field of medical devices, and discloses an arm fixing device for coronary intervention treatment, which comprises a base, wherein an arc-shaped groove is arranged on the base; unidirectional screws are rotationally connected to the two sides of the arc-shaped groove on the base; lifting blocks are threadedly connected to the unidirectional screws; guide rods are arranged on the two sides of the arc-shaped groove on the base; the lifting blocks are slidably connected with the guide rods; a top base is arranged between the two lifting blocks; a first elastic block is connected to the top base and located directly above the arc-shaped groove; second elastic blocks are arranged on the two sides of the first elastic block on the top base; the arm fixing device further comprises a driving mechanism for driving the two unidirectional screws to rotate simultaneously and a linkage mechanism for driving the two second elastic blocks to clamp the arm when the top base moves vertically. The scheme mainly solves the problem that the existing arm fixing device has poor limiting effect on the arm.
Owner:CHONGQING EMERGENCY MEDICAL CENT (CHONGQING FOURTH PEOPLES HOSPITAL CHONGQING INST OF EMERGENCY MEDICINE) +1

A rat coronary heart disease combined with depression treatment intervention system

PendingCN122291053ADiseaseEfficacy
This invention relates to the field of rat coronary heart disease complicated with depression treatment and intervention technology, and discloses a rat coronary heart disease complicated with depression treatment and intervention system, including a multidimensional acquisition module and an intelligent intervention module. The system acquires experimental data, metabolomics data, and efficacy data of intervention programs from all rats through the multidimensional acquisition module, and classifies them into datasets. The intelligent intervention module calculates a disease index based on the multidimensional data, accurately quantifies the severity of symptoms, and achieves dual correlation verification between metabolic mechanisms and pathological phenotypes. The multidimensional correlation has high accuracy. The intelligent intervention module evaluates the treatment effect of each rat after receiving different intervention programs, generates a treatment index, and assesses the population coverage of each intervention program's effect, generating an effectiveness index. It determines the symptom level and efficacy level of each rat, outputs corresponding evaluation results and intervention suggestions, and optimizes the intervention program through population data feedback. The intelligent intervention treatment effect is excellent.
Owner:GUANGXI UNIV OF CHINESE MEDICINE

Systems and methods for providing vehicle intervention therapy

Systems and methods of providing vehicle intervention therapy is provided. First sensor data associated with the occupant of the vehicle is received from a sensor system. A first physiological parameter is generated based on the first sensor data. A physiological state is identified based on the first physiological parameter. The first physiological parameter is compared to a physiological parameter threshold. A first command is issued to a vehicle therapy system to implement intervention therapy associated with the physiological state to the occupant of the vehicle based on the comparison.
Owner:GM GLOBAL TECHNOLOGY OPERATIONS LLC

A biomarker combination and its use in predicting parkinson's disease

The application discloses a biomarker combination and application thereof in predicting Parkinson's disease, and the biomarker combination is composed of ALCAM, IGFALS, SELPLG, ITIH1, ELN, ITIH2, LBP, GPX3, LY6H, SERPINC1, WSCD1, SERPINA6, GPLD1, PON1, GNS, SPON2, CTSL, CLEC3B, OLFM1, CD55, ORM1, BSG and GAPDH. The 23-protein biomarker combination in the application can be used for risk estimation and detection of Parkinson's disease patients, has the advantages of high sensitivity and high specificity, and provides favorable technical support for early screening diagnosis, intervention treatment and the like of Parkinson's disease patients.
Owner:SHANGHAI AIPUTIKANG BIOTECHNOLOGY CO LTD

Application of ergotramine in preparation of medicine for treating post-traumatic stress disorder

PendingCN121370891AAntipyreticAnalgesicsSertralineIntervention treatment
The invention discloses an application of ergomine in preparation of a medicine for treating post-traumatic stress disorder caused by electric shock. According to the method, a post-traumatic stress disorder model is firstly constructed, and the result shows that in post-traumatic stress disorder model animals, remarkable core behavior characteristics such as fear overconsolidation memory and the like are shown. The ergotramine is used for intervention treatment, so that the fear memory fading capability of the model animal is obviously improved; behavior experiment comprehensive evaluation shows that the stiffness time of animals in an ergotramine treatment group is remarkably shortened. Experimental results show that the ergotramine can effectively relieve fear memory disorder of post-traumatic stress disorder model animals. Research finds that when the ergotramine is used for treating mice related to the electric shock complicated post-traumatic stress disorder, the index of an experimental result is superior to that of serotonin reuptake inhibitor medicine sertraline. Related experiments show that the ergotramine has the effect of treating and / or relieving post-traumatic stress disorder and has a good clinical application prospect.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Auxiliary turning-over device for infant patient

ActiveCN223787806UNursing bedsPhysical medicine and rehabilitationIntervention treatment
The utility model relates to the technical field of medical treatment, and provides an auxiliary turning-over device for infant patients, which comprises a bottom pad used for being attached to an external sickbed. A turning-over bag structure for a patient to lie on is arranged on the bottom pad, and an inflation structure which is connected with a corresponding cavity of the turning-over bag structure and used for adjusting the expansion and contraction state of the cavity so as to achieve turning over of the patient and maintain the posture of the turning-over body is further arranged outside the turning-over bag structure. The hospital bed has the advantages of being small in occupied space, capable of automatically assisting a patient in turning over and effectively maintaining the body posture to meet the expected turning-over intervention treatment effect, capable of improving the tidiness of the hospital bed and convenient to store and use. The requirements of hospitalization and daily home nursing are met.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV