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79 results about "Intervention treatment" patented technology

An intervention is a carefully planned process where family, friends and others involved in the person’s life gather together to tell the person about the effect of their addiction and ask him or her to accept treatment. The intervention usually offers a prearranged treatment action plan with clear steps,...

AI-based atrial fibrillation patient health risk prediction method

The invention discloses an AI-based atrial fibrillation patient health risk prediction method, and belongs to the technical field of medical information, and the method specifically comprises the steps: receiving a physiological parameter record and an intervention treatment record of an atrial fibrillation patient, carrying out the time sequence alignment operation, and forming structured patient data; extracting risk-related features from the structured patient data, wherein the risk-related features are divided into basic risk features and intervention response features; inputting the basic risk features into a basic risk prediction network, and outputting a basic risk score; inputting the intervention response characteristics and the basic risk score into an intervention effect separation network together to generate a post-intervention risk score; calculating a net effect value of treatment intervention according to the difference between the basic risk score and the post-intervention risk score; combining the basic risk score, the post-intervention risk score and the net effect value to generate a patient individualized long-term risk prediction trajectory; and accurate prediction of the long-term health risk of the atrial fibrillation patient is realized.
Owner:FUJIAN PROVINCIAL HOSPITAL

Cardiovascular patient group health assessment system based on diet and individual characteristics

The invention relates to the technical field of cardiovascular disease health risk assessment and management, and discloses a cardiovascular patient group health assessment system based on diet and individual characteristics, which comprises a data acquisition module, an analysis and prediction module and a health assessment module. According to the cardiovascular patient group health assessment system based on diet and individual characteristics, a data acquisition module acquires a user data set, a data preprocessing unit identifies the user data set, a risk proportion unit calculates a disease risk ratio Hbfx, and a variable prediction unit calculates a disease prediction data set Fbyc; the health assessment module calculates a comprehensive influence data set Zhyx and comprehensively assesses the influence of significant variables of a user on CVD risks, analysis and assessment are more comprehensive and highly targeted, the health assessment module compares a reference data set according to the comprehensive influence data set Zhyx and judges and assesses corresponding scores, and the effect of early intervention and treatment of cardiovascular diseases is better.
Owner:ZHEJIANG QINGKAI FOOD & HEALTH TECH CO LTD +1

Speech disorder detection method, device, equipment and readable storage medium

The present disclosure relates to a speech disorder detection method, device, equipment and readable storage medium. By acquiring standard audio-visual materials, in response to the pronunciation operation of the to-be-detected object to the standard audio-visual materials, multi-modal pronunciation data is collected, audio acoustic features are extracted based on the pronunciation audio, video visual features are extracted based on the video of the face and oral cavity activity, the audio acoustic features, the video visual features and the demographic information coding data are fused to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, a speech disorder detection result of the to-be-detected object is obtained. Compared with the prior art, the embodiment of the present disclosure can improve the accuracy and comprehensiveness of speech disorder detection, improve the diagnosis efficiency, reduce the dependence on professionals, reduce the burden of medical resources, and clearly determine the specific type of pronunciation problem, thereby providing a scientific basis for subsequent individualized intervention treatment.
Owner:AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS

Application of simvastatin in preparation of medicine for treating post-traumatic stress disorder

The invention discloses an application of simvastatin in preparation of a medicine for treating post-traumatic stress disorder. According to the invention, a post-traumatic stress disorder model is firstly constructed, and a result shows that in post-traumatic stress disorder model animals, obvious core behavior characteristics such as fear memory overconsolidation and anxiety behavior enhancement are shown. When simvastatin is used for intervention treatment, the fear memory fading ability of the model animal is obviously improved, and the anxiety behavior is obviously relieved; behavior experiment comprehensive evaluation shows that the stiffness time of animals in a simvastatin treatment group is remarkably shortened, the standing time and distance proportion of an open arm of an elevated cross maze are remarkably increased, the total movement distance of an open field experiment is remarkably increased, and simvastatin can effectively relieve fear memory disorder and anxiety behaviors of post-traumatic stress disorder model animals.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Cardiovascular interventional therapy device for department of cardiology

The invention discloses a heart and cerebral vessel interventional therapy device for the department of cardiology, and relates to the field of interventional therapy, the heart and cerebral vessel interventional therapy device comprises a linear module track, a U-shaped mounting frame is movably mounted on the linear module track, a lifting plate is slidably mounted on the U-shaped mounting frame, a movable sliding table is slidably mounted on the lifting plate, and an interventional box is arranged on the bottom side of the movable sliding table; an intervention head is arranged at one end of the intervention box. According to the device, medical staff can be helped to carry out heart and cerebral vessel interventional therapy in the state of being far away from X-ray equipment, the medical staff can avoid direct radiation exposure in a shielding radiation room, the harm of radiation to the medical staff is greatly reduced, occupational injuries are reduced, and the treatment efficiency is improved. According to the device, alternate arrangement and use of the guide wire, the catheter and the stent conveying wire can be completed, interventional therapy of heart and cerebral vessels is achieved, meanwhile, the physical strength effect of medical staff in the operation process is lowered, and the medical staff can keep a good physical state to treat more patients.
Owner:SHANXI BETHUNE HOSPITAL (SHANXI ACAD OF MEDICAL SCI SHANXI HOSPITAL OF TONGJI HOSPITAL AFFILIATED TO TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV OF SCI & TECH SHANXI MEDICAL UNIV THIRD HOSPITAL SHANXI MEDICAL UNIV THIRD CLINICAL COLLEGE OF MEDICINE)

Clinical interventional therapy catheter fixing device for department of cardiology

The invention relates to the technical field of catheter fixing devices. The cardiology department clinical interventional therapy catheter fixing device comprises a binding assembly, a first connecting assembly is installed at one end of the binding assembly, a second connecting assembly is installed at the other end of the binding assembly, a limiting assembly is installed at the top of the binding assembly, and a fixing assembly is installed at the top of the binding assembly. The limiting assembly is connected with the fixing assembly and limits the fixing assembly. A binding bandage is bound on the body of a patient, a second fixing shaft slides into clamping grooves in two clamping arms, the second fixing shaft is fixed through the clamping grooves under the torsion action of a first torsion spring, and limiting plates on the inner sides of the clamping grooves can be clamped into limiting grooves in the outer wall of the second fixing shaft, so that the second fixing shaft is fixed. The friction force between the binding bandage and the skin of the patient can be increased through the multiple rubber sheets on the rubber belts at the two ends of the binding bandage, and therefore the installation stability of the binding bandage can be improved.
Owner:CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL HAINAN HOSPITAL

Program and system for self-care or therapy support of mental health

PendingJP2025160091AMental therapiesInformation processingStress-related disorders
To provide a self-care system for stress-related diseases or mental health issues caused by stress.SOLUTION: In a system for self-care of mental health, the system causes an information processing terminal included in the system to provide a user with information of a plurality of therapeutic interventions based on psychotherapy registered in the system on a screen of the information processing terminal in a selectable manner, either sequentially or at any time, continuously for a certain period of time, and further to provide the user with information of a plurality of therapeutic interventions based on the psychotherapy newly registered in the system, either sequentially or at any time, continuously for a certain period.SELECTED DRAWING: Figure 1
Owner:CHIRAL INC

A method and system for risk stratification of chronic coronary syndrome based on coronary microcirculatory resistance index

PendingCN122455361AVery low riskCoronary arteries
The application discloses a kind of chronic coronary syndrome risk stratification methods based on coronary microcirculation resistance index, it is related to medical data processing technical field.The method comprises: the clinical characteristic data of patient to be evaluated is obtained;The clinical characteristic data is input into the preset risk stratification model, and the risk group of the patient to be evaluated is obtained according to preset split condition.The preset split condition determines the split priority by analyzing the nonlinear correlation and the degree of distinction of multidimensional feature data, and generates a multi-layer classification model by combining survival tree algorithm training.The application breaks through the limitation of single index evaluation, effectively captures the nonlinear interaction between clinical indicators, significantly improves the risk stratification accuracy, can accurately identify the very low risk and high-risk subgroup, avoid clinical over-treatment or insufficient intervention treatment, and the model has strong interpretability and is easy to promote clinically.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Controllable bending catheter for use in an intervention

The application provides an intervention treatment controllable bending catheter, and relates to the technical field of medical catheters. The intervention treatment controllable bending catheter comprises a cannula, an adjusting assembly is installed on the cannula, a large fastening ring is threadedly connected to the front of the adjusting assembly, a stabilizing assembly is threadedly connected to the front of the large fastening ring, a rear section assembly is fixedly installed at the front of the stabilizing assembly, a plurality of middle section assemblies are installed at the front of the rear section assembly, and a connecting outer tube and a connecting inner tube are installed between adjacent middle section assemblies. In use, the front section assembly is inserted into a human body, the front section assembly, the middle section assemblies and the rear section assembly are in a non-forced connection state, the insertion into the human body is facilitated, after the insertion, the adjusting assembly and the large fastening ring are rotated to tighten the steel wire, the front section assembly, the middle section assemblies and the rear section assembly enter a forced connection state under the action of the steel wire, and the front section assembly, the middle section assemblies and the rear section assembly are integrated, thereby facilitating subsequent operation.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD

Efficacy evaluation and remote follow-up platform for ultrasound intervention treatment of mastitis

ActiveCN121565361BReal-time synchronizationavoid identifyingMedical data miningPatient-specific dataPatient dataMastitis
The present application relates to the field of medical informatization and remote diagnosis and treatment technology, and discloses a curative effect evaluation and remote follow-up platform for mammitis ultrasonic interventional treatment. The platform integrates the imageological changes, physiological parameter trajectories, operation records and follow-up feedback of patients through a data processing module. A window recognition module dynamically divides curative effect observation windows and conventional observation windows according to treatment and feedback time points. A patient clustering module clusters patients based on the timing mode of physiology and images within the curative effect window, and identifies different response modes. A feature extraction module extracts typical operation features and follow-up response baselines of each patient community accordingly. A strategy generation module calculates the multidimensional matching degree by matching new patient data with the feature baselines of each community, and generates individualized follow-up strategies, thereby realizing adaptive and accurate definition of the curative effect evaluation window and individualized and directional optimization of follow-up management.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Preparation and application of kidney dual-targeting black phosphorus nano platform for treating acute kidney injury

The invention provides preparation and application of a kidney dual-targeting black phosphorus nano platform for treating acute kidney injury. Firstly, black phosphorus nanosheets and NH2-PEG-NH2 are mixed and then dispersed into deionized water, centrifugation is repeated, supernate is discarded, and a BP-PEG solution is obtained; kim-1 targeted polypeptide LTH powder is dissolved in deionized water, then EDC and NHS are added for a light-shielding reaction, a BP-PEG solution is added, light-shielding stirring is continued to obtain a BP-PEG-LTH mixture, then 4-octyl itaconic acid is added, then a PBS solution is added, light-shielding magnetic stirring is carried out, and the kidney double-targeting black phosphorus nano platform is obtained. The kidney dual-targeting black phosphorus nano platform is used as an intravenous injection for treating acute kidney injury, oxidative stress can be rapidly and effectively inhibited, inflammation is resisted, intercellular burial is promoted, malignant development of AKI is inhibited to a great extent, and the purpose of short-term specific intervention treatment after AKI is achieved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Application of hederagenin in preparation of medicine for maintaining dryness of ATII

The invention discloses a novel application of hederagenin in preparation of a medicine for maintaining the dryness of alveolar II epithelial cells, the hederagenin is definitely used for preparing the medicine for maintaining the dryness of the alveolar II epithelial cells for the first time, and the repairing effect of the hederagenin on ATII dry damage is verified through in-vivo and in-vitro experiments. A brand new treatment strategy is provided for lung diseases such as acute lung injury, pulmonary fibrosis and the like which are characterized by ATII dry failure, the technical blank of intervention of natural active ingredients in ATII dry is filled up, a new way which is efficient, low in cost and easy to obtain is provided for ATII dry maintenance, the concentration of a medicine prepared from the natural active ingredients is screened, and the clinical application prospect is wide. An important theoretical basis is provided for further medication and medicine preparation, meanwhile, the pharmacological application range of the hederagenin is expanded, and a new target and a new strategy are provided for subsequent intervention treatment of lung diseases such as acute lung injury and pulmonary fibrosis needing injury repair.
Owner:GANSU UNIV OF CHINESE MEDICINE

System and method for identifying infection risk in dialysis patients

A method and system for determining a risk of an infection for a patient is disclosed. In one embodiment, the system and method includes extracting patient data from one or more databases corresponding to a pool of patients under treatment; using the extracted patient data with one or more predictive models to generate a respective patient risk score for each patient in the pool of patients for developing an infection within a selected time period; generating a report including at least a portion of an identified subset of the pool of patients and their respective patient risk scores; and transmitting the report to one or more healthcare institutions that further identify one or more patients from the portion of the identified subset of the pool of patients for an intervention treatment, consultation, training, or a combination thereof.
Owner:FRESENIUS MEDICAL CARE HOLDINGS INC

Gait intervention method for dyskinesia disease population, music generation method, device, system, equipment and medium

The application discloses a gait intervention method for a dyskinesia disease population, a music generation method, device, system, equipment and medium, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process that a target object suffering from a dyskinesia disease is intervened and treated according to abnormal gait by rhythm music, collecting multi-modal physiological data of the target object in real time, and dynamically determining a plurality of motion symptom characteristic indexes related to gait of the target object according to the multi-modal physiological data; determining music parameters at each moment in real time according to the plurality of motion symptom characteristic indexes; dynamically adjusting notes of the rhythm music at each moment according to the music parameters at each moment, and generating rhythm music adapted to the current gait condition of the target object. According to the scheme, the rhythm music can be more comprehensively and individually dynamically adjusted, and is more suitable for the current gait condition of the target object, so that the effect of abnormal gait rehabilitation treatment, intervention and correction can be improved.
Owner:北京中科睿医信息科技有限公司

Precise pushing equipment for bronchial intervention medicine

The invention relates to the field of bronchial interventional therapy, in particular to bronchial interventional medicine accurate pushing equipment which comprises a lantern ring sealing tile, a hinge part is arranged on one side of the outer arc face of the lantern ring sealing tile, and the lantern ring sealing tile is connected with an annular base disc through the hinge part of the outer arc face. A deformation cavity of the built-in guide sleeve is filled with the outer arc face of the medicine storage bag and tightly attached to the inner inclined end, a contact face gap is filled with a reserved cavity of the elastic blocking piece, and the sealing gasket is extruded through cooperation with the fastening nut to form port sealing. In the dosing process, a clamping structure of a conical clamping block and an external guide sleeve is combined with a hinged fixed elastic blocking piece of an annular base disc of a lantern ring sealing tile to synchronously reinforce sealing of a contact surface, so that liquid medicine is effectively prevented from being stored; a leakage path in the pushing and resetting process not only avoids medicine dosage loss and ensures that the medicine amount delivered to a lesion area reaches an expected treatment standard, but also prevents local stimulation or adverse reaction caused by the fact that leaked liquid medicine makes contact with normal tissues of the bronchial tube, and the treatment risk of a patient is reduced.
Owner:LONGGANG DISTRICT CENT HOSPITAL OF SHENZHEN

Application of 4-VPS in preparation of kit for screening and / or diagnosing hypertensive kidney injury

PendingCN121805570AComponent separationMicrobiological testing/measurementEnd-stage kidney diseaseHypertensive Nephropathy
The invention relates to the technical field of biological medicine, in particular to application of 4-VPS in preparation of a kit for screening and / or diagnosing hypertensive kidney injury. According to the invention, a detection sample of 4-VPS is peripheral blood, and the sample is convenient to collect, minimally invasive and easy to popularize clinically; meanwhile, functional experiments prove that 4-VPS can directly induce kidney injury, early diagnosis of hypertensive nephropathy is achieved through 4-VPS, a patient can receive intervention treatment in the early stage of the disease, the disease is delayed or even prevented from developing into the end-stage nephropathy, the requirement of the patient for subsequent dialysis treatment or kidney transplantation is reduced, personal medical expenditure is reduced, and the treatment cost is reduced. Meanwhile, consumption of social medical resources is reduced, and remarkable economic benefits are achieved.
Owner:SHANGHAI UNIV OF MEDICINE & HEALTH SCI

Interventional method, device, electronic device and storage medium for deep brain stimulation

The application provides an intervention method, device, electronic equipment and storage medium for deep brain stimulation, wherein the intervention method comprises: acquiring an electroencephalogram signal of a target user, determining an electroencephalogram feature set of the electroencephalogram signal, determining intervention-related information for the target user based on the electroencephalogram feature set, and performing intervention processing according to the intervention-related information. In this way, when the DBS intervention is performed, the intervention-related information suitable for the patient's disease condition can be automatically selected according to the electroencephalogram feature of the patient, so that the effect of precise intervention treatment is achieved.
Owner:BEIJING NAOLU TECH CO LTD

Use of levosimendan in the preparation of a medicament for the treatment of pulmonary arterial hypertension

The application provides application of levosulpiride in preparation of a medicine for treating pulmonary arterial hypertension, and the medicine comprises levosulpiride as an active ingredient. Through a pulmonary arterial hypertension model of a rat, the application gives an intervention treatment of levosulpiride, and the effect of levosulpiride on pulmonary vessels is determined: the levosulpiride can reduce the mean pulmonary arterial pressure of a pulmonary arterial hypertension rat, reduce pulmonary vascular resistance, and improve right ventricle and pulmonary vessel remodeling, thereby providing a strategy for developing the medicine for treating the pulmonary arterial hypertension.
Owner:SHANGHAI PULMONARY HOSPITAL (SHANGHAI OCCUPATIONAL DISEASE PREVENTION & CONTROL INSTITUTE)

Percutaneous liver puncture biliary drainage auxiliary device for tumor clinical interventional therapy

PendingCN121868599AMedical devicesCatheterInterventional oncologyIntervention treatment
The invention discloses a tumor clinical interventional therapy percutaneous liver puncture biliary drainage auxiliary device, comprising: a clamping protection mechanism comprising a clamping frame assembly and a gooseneck assembly which is arranged on the clamping frame assembly and can be adjusted in position along the vertical direction; the complication monitoring assembly comprises a monitoring host installed on the clamping frame assembly, and a temperature sensor and an ultrasonic flow sensor which are electrically connected with the monitoring host; the temperature sensor is used for monitoring the body temperature of a patient in real time, and the ultrasonic flow sensor is connected with the drainage tube and used for achieving non-invasive monitoring of the bile flow velocity; the binding belt assembly is used for being fixed to the waist and abdomen of a patient in a surrounding mode, and the binding belt assembly is provided with a first through hole used for a drainage tube to pass through and a second through hole used for a temperature probe of a temperature sensor to pass through; the problems that an existing percutaneous liver puncture biliary tract drainage auxiliary device is poor in drainage tube protection effect and insufficient in complication risk monitoring capacity are solved.
Owner:SHIJIAZHUANG PEOPLES HOSPITAL

Treatment assistance device, treatment assistance program, and treatment assistance system

PCT designated stageWO2025203306A1Mental therapiesDiseaseMedical equipment
The present invention executes a process based on cognitive behavior therapy for chronic diseases by means of a treatment assistance application installed on a patient terminal 1 for use by a patient. As a functional configuration for executing the process, a treatment assistance device comprises: a provocation content presentation unit 111 for presenting, to the patient and on the patient terminal 1, a content that provokes a symptom or a negative feeling; a reaction information acquisition unit 112 for acquiring information indicating a reaction from the patient during or after the presentation of the provocation content, through an input operation by the patient to the patient terminal 1 or a detection process by the treatment assistance application; and an intervention process determination unit 113 for determining, on the basis of the acquired reaction information, a treatment intervention process to be executed. As a result, the need for using a VR / AR projection device as a means for presenting the provocation content is eliminated, and the need for using an electroencephalograph or a specialized medial apparatus as a means for acquiring the reaction information from the patient with respect to the presentation of the provocation content is also eliminated.
Owner:SUSTAINABLE MEDICINE INC +1

Clinical interventional therapy catheter fixing device for department of cardiology

The invention relates to the technical field of medical auxiliary instruments, in particular to a cardiology department clinical interventional therapy catheter fixing device which comprises a catheter body used for conducting in-vivo puncture, a plurality of adhesive tape layers used for being attached to the skin surface are arranged on the outer side of the catheter body, a connecting block is arranged on the outer wall of the catheter body, and a plurality of attaching parts are fixedly connected to the periphery of the connecting block in the circumferential direction. The bottom of the attaching part is fixedly connected with a deformable stretching layer, the stretching layer is located between the adjacent adhesive tape layers, the center of the stretching layer is fixedly connected with a suction cup, the suction cup communicates with a suction mechanism through an air pipe, and the suction mechanism is located on the connecting block; the suction mechanism is electrically connected with a control panel, the control panel is electrically connected with a plurality of pressure sensors, the pressure sensors are used for measuring pressure data of the adhesive tape layer on the skin, and the control panel controls the working condition of the suction mechanism based on the pressure data; while the stability of external fixation of the catheter is guaranteed, the skin breathability and water permeability are improved, and clinical requirements are met.
Owner:YUEYANG PEOPLES HOSPITAL

Application of arginine vasopressin in treatment of slow transit constipation

The invention discloses application of arginine vasopressin in treatment of slow transit constipation, and relates to the technical field of medicines for treating slow transit constipation. The arginine vasopressin nose drop is found to have a very good treatment effect on slow transit constipation for the first time, and especially for loperamide-induced slow transit constipation, the arginine vasopressin nose drop can effectively promote intestinal tract movement and improve constipation symptoms. The arginine vasopressin is prepared into nose drops, can bypass a blood brain barrier to enter the brain, directly targets downstream nuclei of AVP neurons in a hypothalamic para-ventricular nucleus PVN nuclei, and intervenes treatment in the nerve center, and the effect is better. The discovery of the invention expands a new application for arginine vasopressin drugs, and also provides a new idea for development of constipation drugs.
Owner:WUHAN BAIYINGNUO MEDICAL TECHNOLOGY CO LTD

Network addiction intervention method and system based on sand table game interaction data analysis

The invention relates to the technical field of network addiction intervention, in particular to a network addiction intervention method and system based on sand table game interaction data analysis. The method comprises the following steps: evaluating the network addiction degree of a patient according to analyzed network addiction specific problem data. And the virtual feedback unit performs virtual intervention treatment according to the formulated network addiction intervention strategy and the network addiction condition data of the network addiction patient, can provide a personalized intervention scheme based on the personal network addiction condition data of the patient, and analyzes the behavior pattern and the use habit of the patient. The virtual treatment can provide customized suggestions and guidance according to the needs of the patient, feedback information about network use behaviors of the patient can be provided for the patient in time through virtual feedback data of the patient, and the real-time performance can help the patient to better understand the behavior mode of the patient and adjust and improve the intervention treatment effect in time, so that the intervention treatment efficiency is improved. And the treatment effect is improved.
Owner:LI SHOULONG PSYCHOLOGICAL SCI & TECH (QINGDAO) CO LTD

Human glioma DNA marker and its application

The present application belongs to the technical field of biological medicine, and particularly relates to a human glioma DNA marker and application thereof. The marker comprises three DNAs, namely PBK, SPP1 and LTA, and the corresponding DNA nucleotide sequences are shown in SEQ ID NO. 1, SEQ ID NO. 2 and SEQ ID NO. 3, respectively. The present application provides a molecular marker for glioma prognosis prediction and application thereof. The transcriptome dataset of glioma patients is obtained by TCGA, CGGA-array and CGGA-seq datasets, and three gene markers are screened. Research shows that the three gene markers can independently predict the survival of glioma patients, and can be used as a reference index for judging the survival time of glioma prognosis and predicting the survival risk. By studying the relationship between the three gene markers and the clinical prognosis of glioma patients, a new marker is provided for the prognosis of glioma, so as to improve the timely intervention treatment of glioma patients and improve the clinical prognosis of patients. It has very important significance in clinical practice.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

A biomarker combination and its application in predicting breast cancer risk

The present invention discloses a biomarker combination and its application in predicting breast cancer risk, specifically disclosing the application of a biomarker combination in preparing a product for predicting breast cancer, wherein the biomarker combination is composed of ADPRS, ARMC8, ASCC3, B3GAT3, BLVRB, CA1, CDC37, DLG1, DSC3, DUSP3, EIF5AL1, EWSR1, GCNT3, H3-4, H3C1, H3C15, HBB, HBE1, HNRNPA0, HSPA6, ITGA6, MSL1, NUP155, PDCD10, PLBD2, PXDN, RDH10, RECK, RUVBL1, SAMHD1, SLC30A7, SMARCA5, SPG21, TCIRG1, TRIOBP, UFC1 and UROD. The marker combination provided in the present invention can be used as risk estimation and detection for breast cancer patients, has the advantages of high sensitivity and high specificity, and provides favorable technical support for predicting the occurrence and development of breast cancer. The development of corresponding prediction devices using the above-mentioned marker combinations can provide great convenience for early clinical diagnosis or intervention treatment.
Owner:SHANGHAI AIPUTIKANG BIOTECHNOLOGY CO LTD

Method for improving freeze-thaw ovarian function by adopting mT-level pulsed magnetic field

The invention belongs to the field of bioelectromagnetism, and particularly discloses a method for improving functions of frozen and thawed ovarian tissues by adopting an mT-level pulsed magnetic field. According to the method, ovarian tissue which is subjected to vitrification freezing and resuscitation is exposed in a pulsed magnetic field with specific parameters for intervention treatment; wherein the intensity of the pulsed magnetic field is 5 mT, the current period is 1000-6000 [mu] s, the duty ratio is 50%, the pulse repetition number is 30, and the pulse interval is 60 ms. According to the application, a non-intrusive and drug-residue-free physical intervention means is adopted, inflammatory response can be effectively inhibited, oxidative stress injury can be relieved, the number of functional mitochondria is increased by up-regulating mitochondrial fusion genes (such as Mfn1 and Mfn2), the energy metabolism state of cells is fundamentally improved, the survival rate of transplanted ovarian tissue is remarkably increased, the functional life of the ovarian tissue is prolonged, and the survival rate of the ovarian tissue is increased. The method is simple to operate, low in cost and good in clinical application prospect.
Owner:HUAZHONG UNIV OF SCI & TECH

Arm fixing device for coronary interventional therapy

The invention relates to the technical field of medical instruments, in particular to an arm fixing device for coronary interventional therapy, which comprises a second fixing frame and further comprises an arm supporting plate, a palm supporting plate is mounted at one end of the second fixing frame through a damping assembly, and a mounting plate is fixedly mounted at one end, away from the arm supporting plate, of the palm supporting plate. Five sets of limiting assemblies are arranged on the installation plate, each limiting assembly comprises a finger root clamping plate, the finger root clamping plates are installed on the installation plate through sliding assemblies, the upper ends of the finger root clamping plates are rotationally connected with an upper finger plate, and a plurality of finger bandages are fixedly installed on the side wall of the upper finger plate. Only the finger roots are properly fixed, two joints on the fingers are not limited, main activity sources are effectively restrained, tiny jumping conducted to the wrist is reduced, meanwhile, the finger opening range is larger, the mechanical leverage effect is weakened, torque generated by finger micro-motion is smaller and is more difficult to conduct to the near end, the whole forearm-wrist-hand system is more stable, and the mechanical leverage effect is improved. And the puncture success rate can be improved.
Owner:SHANGHAI JINGAN DISTRICT SHIBEI HOSPITAL

Intervention device for myopia and treatment method thereof

The invention relates to a myopia intervention device and a treatment method thereof. The myopia intervention device comprises a host and a replaceable intelligent eye pad connected with the host, the intelligent eye pad is designed to be of a multi-layer structure, and sequentially comprises a hydrogel contact layer used for being attached to the skin and conducting electricity from the contact eye skin to the inside; the iontophoresis layer is used for generating pulse current to drive nutrient substances in blood to directionally permeate to sclera tissues; the optical layer is used for emitting monochromatic light with different wavelengths to act on cells of the retina; the micro magnetic field layer is used for generating a micro magnetic field with specific form and strength; the host is used for controlling the iontophoresis electrode layer, the optical layer and the micro-magnetic field layer to work cooperatively according to a preset time sequence and performing intervention treatment on eyes; according to the technical scheme, the myopia intervention treatment effect can be improved.
Owner:LIUZHOU DINGYU INFORMATION TECHNOLOGY CO LTD

Targeted periprosthetic infection detection, drug delivery and drug intervention system and method and application thereof

PendingCN121313829AAntibacterial agentsEnergy modified materialsMicrococcal nucleaseDrug release
The invention discloses a targeted periprosthetic infection detection, drug delivery and drug intervention system as well as a method and application thereof, and belongs to the field of biological medicine. The detection and drug intervention system comprises a micrococcus nuclease sensitive biological probe, a functional silicon plastid for bearing the micrococcus nuclease sensitive biological probe, light-cured hydrogel and an implant, wherein medicines are carried in the functional silica plastid; a micrococcus nuclease sensitive biological probe is connected to the surface of a functional silicon plastid through electrostatic interaction force to obtain a nuclease probe functional silicon plastid, and the nuclease probe functional silicon plastid is connected to the surface of an implant through photocuring hydrogel. According to the system provided by the invention, the detection is realized, the delivery of the medicine is also realized, and the release of the medicine can also be realized when the occurrence of infection around the prosthesis is judged, so that the intervention treatment of the medicine is carried out.
Owner:SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)

Visual positioning device for pain interventional therapy under ultrasonic guidance

The invention discloses a visual positioning device for pain interventional therapy under ultrasonic guidance, and relates to the technical field of auxiliary instruments for pain medical interventional therapy. The device comprises a support and a multi-joint arm, one end of the multi-joint arm is fixedly connected with the top end of the support, an ultrasonic probe fixing assembly and a treatment instrument guiding assembly are arranged at one end of the multi-joint arm, the ultrasonic probe fixing assembly comprises an ultrasonic probe fixing box, and an elastic piece and a clamping plate are arranged in the ultrasonic probe fixing box; the elastic piece and the clamping plate are used for clamping the ultrasonic probe in the ultrasonic probe fixing box, the treatment instrument guiding assembly comprises a fixing pipe and a depth limiting pipe, and stable fixing of the ultrasonic probe and precise guiding, depth adjusting and angle locking of a puncture needle can be achieved through the ultrasonic probe fixing assembly and the treatment instrument guiding assembly; positioning deviation caused by handheld operation is avoided, and the accuracy and safety of pain interventional therapy under ultrasonic guidance are improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV