107 results about "Intervention treatment" patented technology

The invention discloses a gait intervention method, a music generation method, a device, a system, equipment and a medium for people suffering from dyskinesia diseases, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process of performing abnormal gait intervention treatment on a target object suffering from dyskinesia according to rhythmic music, acquiring multi-modal physiological data of the target object in real time, and dynamically determining a plurality of gait-related movement symptom characteristic indexes of the target object according to the multi-modal physiological data; determining music parameters at each moment in real time according to the multiple exercise symptom characteristic indexes; and dynamically adjusting notes of the rhythmic music at each moment according to the music parameters at each moment, and generating the rhythmic music adaptive to the current gait condition of the target object. According to the scheme, the rhythm music can be dynamically adjusted more comprehensively and individually, the current gait condition of the target object can be better met and adapted, and the effect of abnormal gait rehabilitation treatment, intervention and correction can be improved.

The invention relates to a voice disorder detection method, device and equipment and a readable storage medium. The method comprises the following steps: acquiring a standard audio-visual material, responding to a pronunciation operation of a to-be-detected object on the standard audio-visual material, acquiring multi-modal pronunciation data, extracting audio acoustic features based on the pronunciation audio, extracting video visual features based on videos of facial and oral activities, and displaying the extracted audio acoustic features and the extracted video visual features. And performing multi-modal feature fusion on the audio acoustic features, the video visual features and the demographic information coding data to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, obtaining a voice obstacle detection result of the to-be-detected object. Compared with the prior art, according to the embodiment of the invention, through multi-modal feature fusion, the accuracy and comprehensiveness of voice disorder detection can be improved, the diagnosis efficiency can be improved, the dependence on professionals can be reduced, the burden of medical resources can be reduced, the specific type of pronunciation problems can be clarified, and a scientific basis can be provided for subsequent personalized intervention treatment.

The invention discloses an abnormal gait intervention correction method, a music generation method, a device, a system, equipment and a medium, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process of performing abnormal gait intervention treatment on a target object according to rhythmic music, acquiring multi-modal physiological data of the target object in real time, and determining multi-dimensional emotional characteristics and body physiological characteristics of the target object according to the multi-modal physiological data; based on the emotion features and the body physiological features, music parameters at each moment are determined according to the multi-modal physiological data and gait parameters; and according to the music parameter at each moment, dynamically generating rhythmic music adapted to the current physiological state of the target object. According to the scheme, multi-dimensional collaborative optimization of the rhythmic music is realized, the individuation and emotion expression of the rhythmic music are improved, and the synchronization rate of gait motion-hearing is improved.

The invention discloses an AI-based atrial fibrillation patient health risk prediction method, and belongs to the technical field of medical information, and the method specifically comprises the steps: receiving a physiological parameter record and an intervention treatment record of an atrial fibrillation patient, carrying out the time sequence alignment operation, and forming structured patient data; extracting risk-related features from the structured patient data, wherein the risk-related features are divided into basic risk features and intervention response features; inputting the basic risk features into a basic risk prediction network, and outputting a basic risk score; inputting the intervention response characteristics and the basic risk score into an intervention effect separation network together to generate a post-intervention risk score; calculating a net effect value of treatment intervention according to the difference between the basic risk score and the post-intervention risk score; combining the basic risk score, the post-intervention risk score and the net effect value to generate a patient individualized long-term risk prediction trajectory; and accurate prediction of the long-term health risk of the atrial fibrillation patient is realized.

The invention belongs to the technical field of medical health, and provides a precise intervention treatment system and method based on personalized nutrition metabolism assessment, and the system comprises a data collection module which is used for collecting the physiological data, nutrition intake data, gene information, microbiome data and lifestyle data of an individual; the metabolism evaluation module is used for inputting the data acquired by the data acquisition module into a metabolism evaluation model based on deep learning; the intervention scheme generation module is used for evaluating a result and an individual health target based on the metabolic condition; through joint cooperation of the data acquisition module, the metabolism evaluation module and the intervention scheme generation module, in combination with deep learning and a multi-objective optimization algorithm, the system can provide a more personalized and scientific health management scheme according to the specific condition of an individual, the health management effect and the success rate of disease intervention are improved, and the system is suitable for popularization and application. And powerful support is provided for individual health management and disease prevention.

The invention discloses an optimization method and device for an abnormal gait intervention treatment scheme, equipment and a medium, and relates to the technical field of intelligent medical treatment. The specific implementation mode comprises the steps that in the process of conducting abnormal gait intervention treatment on a target object, multi-modal physiological data and gait data of the target object are collected in real time; performing time sequence analysis on the multi-modal physiological data and the gait data within a preset duration, and dynamically and quantitatively evaluating the training state conversion condition of the target object; and if the training state conversion condition is that a training state type changes, optimizing related parameters of a current abnormal gait and rhythm intervention scheme, and generating a new abnormal gait and rhythm intervention scheme adaptive to the gait state and the physiological state of the target object to perform abnormal gait intervention treatment. According to the scheme, the individuation and adaptability of a new abnormal gait rhythm intervention scheme can be improved, and then the effect of abnormal gait intervention rehabilitation treatment can be improved.

The invention relates to the technical field of cardiovascular disease health risk assessment and management, and discloses a cardiovascular patient group health assessment system based on diet and individual characteristics, which comprises a data acquisition module, an analysis and prediction module and a health assessment module. According to the cardiovascular patient group health assessment system based on diet and individual characteristics, a data acquisition module acquires a user data set, a data preprocessing unit identifies the user data set, a risk proportion unit calculates a disease risk ratio Hbfx, and a variable prediction unit calculates a disease prediction data set Fbyc; the health assessment module calculates a comprehensive influence data set Zhyx and comprehensively assesses the influence of significant variables of a user on CVD risks, analysis and assessment are more comprehensive and highly targeted, the health assessment module compares a reference data set according to the comprehensive influence data set Zhyx and judges and assesses corresponding scores, and the effect of early intervention and treatment of cardiovascular diseases is better.

The present disclosure relates to a speech disorder detection method, device, equipment and readable storage medium. By acquiring standard audio-visual materials, in response to the pronunciation operation of the to-be-detected object to the standard audio-visual materials, multi-modal pronunciation data is collected, audio acoustic features are extracted based on the pronunciation audio, video visual features are extracted based on the video of the face and oral cavity activity, the audio acoustic features, the video visual features and the demographic information coding data are fused to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, a speech disorder detection result of the to-be-detected object is obtained. Compared with the prior art, the embodiment of the present disclosure can improve the accuracy and comprehensiveness of speech disorder detection, improve the diagnosis efficiency, reduce the dependence on professionals, reduce the burden of medical resources, and clearly determine the specific type of pronunciation problem, thereby providing a scientific basis for subsequent individualized intervention treatment.

The invention discloses an application of simvastatin in preparation of a medicine for treating post-traumatic stress disorder. According to the invention, a post-traumatic stress disorder model is firstly constructed, and a result shows that in post-traumatic stress disorder model animals, obvious core behavior characteristics such as fear memory overconsolidation and anxiety behavior enhancement are shown. When simvastatin is used for intervention treatment, the fear memory fading ability of the model animal is obviously improved, and the anxiety behavior is obviously relieved; behavior experiment comprehensive evaluation shows that the stiffness time of animals in a simvastatin treatment group is remarkably shortened, the standing time and distance proportion of an open arm of an elevated cross maze are remarkably increased, the total movement distance of an open field experiment is remarkably increased, and simvastatin can effectively relieve fear memory disorder and anxiety behaviors of post-traumatic stress disorder model animals.

The invention discloses a heart and cerebral vessel interventional therapy device for the department of cardiology, and relates to the field of interventional therapy, the heart and cerebral vessel interventional therapy device comprises a linear module track, a U-shaped mounting frame is movably mounted on the linear module track, a lifting plate is slidably mounted on the U-shaped mounting frame, a movable sliding table is slidably mounted on the lifting plate, and an interventional box is arranged on the bottom side of the movable sliding table; an intervention head is arranged at one end of the intervention box. According to the device, medical staff can be helped to carry out heart and cerebral vessel interventional therapy in the state of being far away from X-ray equipment, the medical staff can avoid direct radiation exposure in a shielding radiation room, the harm of radiation to the medical staff is greatly reduced, occupational injuries are reduced, and the treatment efficiency is improved. According to the device, alternate arrangement and use of the guide wire, the catheter and the stent conveying wire can be completed, interventional therapy of heart and cerebral vessels is achieved, meanwhile, the physical strength effect of medical staff in the operation process is lowered, and the medical staff can keep a good physical state to treat more patients.

The invention relates to the technical field of catheter fixing devices. The cardiology department clinical interventional therapy catheter fixing device comprises a binding assembly, a first connecting assembly is installed at one end of the binding assembly, a second connecting assembly is installed at the other end of the binding assembly, a limiting assembly is installed at the top of the binding assembly, and a fixing assembly is installed at the top of the binding assembly. The limiting assembly is connected with the fixing assembly and limits the fixing assembly. A binding bandage is bound on the body of a patient, a second fixing shaft slides into clamping grooves in two clamping arms, the second fixing shaft is fixed through the clamping grooves under the torsion action of a first torsion spring, and limiting plates on the inner sides of the clamping grooves can be clamped into limiting grooves in the outer wall of the second fixing shaft, so that the second fixing shaft is fixed. The friction force between the binding bandage and the skin of the patient can be increased through the multiple rubber sheets on the rubber belts at the two ends of the binding bandage, and therefore the installation stability of the binding bandage can be improved.

To provide a self-care system for stress-related diseases or mental health issues caused by stress.SOLUTION: In a system for self-care of mental health, the system causes an information processing terminal included in the system to provide a user with information of a plurality of therapeutic interventions based on psychotherapy registered in the system on a screen of the information processing terminal in a selectable manner, either sequentially or at any time, continuously for a certain period of time, and further to provide the user with information of a plurality of therapeutic interventions based on the psychotherapy newly registered in the system, either sequentially or at any time, continuously for a certain period.SELECTED DRAWING: Figure 1

The invention discloses an abnormal gait intervention correction method and device based on rhythmic auditory stimulation, electronic equipment and a medium, and relates to the technical field of intelligent medical treatment. The method comprises the steps that when abnormal gait intervention treatment is conducted on a target object according to rhythmic audio, inertial data of the two feet of the target object are collected in real time; taking the first preset duration as a time interval, calculating a temporary gait cycle rhythm according to the inertial data in each first preset duration, and obtaining a plurality of temporary gait cycle rhythms; a second preset time length is used as a time interval, a real-time gait cycle rhythm is calculated based on the at least two temporary gait cycle rhythms according to the second preset time length, and the second preset time length is larger than the first preset time length; and dynamically adjusting the rhythm of the rhythm audio according to the rhythm of the real-time gait cycle, and performing rehabilitation treatment on abnormal gaits based on the rhythm of the adjusted rhythm audio. According to the scheme, the rhythm of the audio can be scientifically, accurately and reasonably set, and the intervention effect of abnormal gaits can be improved.

The application discloses a kind of chronic coronary syndrome risk stratification methods based on coronary microcirculation resistance index, it is related to medical data processing technical field.The method comprises: the clinical characteristic data of patient to be evaluated is obtained;The clinical characteristic data is input into the preset risk stratification model, and the risk group of the patient to be evaluated is obtained according to preset split condition.The preset split condition determines the split priority by analyzing the nonlinear correlation and the degree of distinction of multidimensional feature data, and generates a multi-layer classification model by combining survival tree algorithm training.The application breaks through the limitation of single index evaluation, effectively captures the nonlinear interaction between clinical indicators, significantly improves the risk stratification accuracy, can accurately identify the very low risk and high-risk subgroup, avoid clinical over-treatment or insufficient intervention treatment, and the model has strong interpretability and is easy to promote clinically.

The application provides an intervention treatment controllable bending catheter, and relates to the technical field of medical catheters. The intervention treatment controllable bending catheter comprises a cannula, an adjusting assembly is installed on the cannula, a large fastening ring is threadedly connected to the front of the adjusting assembly, a stabilizing assembly is threadedly connected to the front of the large fastening ring, a rear section assembly is fixedly installed at the front of the stabilizing assembly, a plurality of middle section assemblies are installed at the front of the rear section assembly, and a connecting outer tube and a connecting inner tube are installed between adjacent middle section assemblies. In use, the front section assembly is inserted into a human body, the front section assembly, the middle section assemblies and the rear section assembly are in a non-forced connection state, the insertion into the human body is facilitated, after the insertion, the adjusting assembly and the large fastening ring are rotated to tighten the steel wire, the front section assembly, the middle section assemblies and the rear section assembly enter a forced connection state under the action of the steel wire, and the front section assembly, the middle section assemblies and the rear section assembly are integrated, thereby facilitating subsequent operation.

The present application relates to the field of medical informatization and remote diagnosis and treatment technology, and discloses a curative effect evaluation and remote follow-up platform for mammitis ultrasonic interventional treatment. The platform integrates the imageological changes, physiological parameter trajectories, operation records and follow-up feedback of patients through a data processing module. A window recognition module dynamically divides curative effect observation windows and conventional observation windows according to treatment and feedback time points. A patient clustering module clusters patients based on the timing mode of physiology and images within the curative effect window, and identifies different response modes. A feature extraction module extracts typical operation features and follow-up response baselines of each patient community accordingly. A strategy generation module calculates the multidimensional matching degree by matching new patient data with the feature baselines of each community, and generates individualized follow-up strategies, thereby realizing adaptive and accurate definition of the curative effect evaluation window and individualized and directional optimization of follow-up management.

The invention provides a digital health index data management method and management system, and belongs to the technical field of digital therapy, and the method comprises the steps: generating at least one index for a specific disease to be treated in the digital therapy according to the disease; based on the generated at least one index for the disease, obtaining a calculation rule of the index; performing calculation processing on the collected index related data according to the calculation rule to obtain a calculation processing result and outputting the calculation processing result; the system comprises an index generation module, a calculation rule acquisition module and a data calculation processing module. According to the invention, the patient data collected by the digital therapy can be effectively utilized, and the adjustment of the intervention scheme of the digital therapy can be guided, so that the intervention treatment effect of the digital therapy can be improved.

The invention provides preparation and application of a kidney dual-targeting black phosphorus nano platform for treating acute kidney injury. Firstly, black phosphorus nanosheets and NH2-PEG-NH2 are mixed and then dispersed into deionized water, centrifugation is repeated, supernate is discarded, and a BP-PEG solution is obtained; kim-1 targeted polypeptide LTH powder is dissolved in deionized water, then EDC and NHS are added for a light-shielding reaction, a BP-PEG solution is added, light-shielding stirring is continued to obtain a BP-PEG-LTH mixture, then 4-octyl itaconic acid is added, then a PBS solution is added, light-shielding magnetic stirring is carried out, and the kidney double-targeting black phosphorus nano platform is obtained. The kidney dual-targeting black phosphorus nano platform is used as an intravenous injection for treating acute kidney injury, oxidative stress can be rapidly and effectively inhibited, inflammation is resisted, intercellular burial is promoted, malignant development of AKI is inhibited to a great extent, and the purpose of short-term specific intervention treatment after AKI is achieved.

The invention discloses a novel application of hederagenin in preparation of a medicine for maintaining the dryness of alveolar II epithelial cells, the hederagenin is definitely used for preparing the medicine for maintaining the dryness of the alveolar II epithelial cells for the first time, and the repairing effect of the hederagenin on ATII dry damage is verified through in-vivo and in-vitro experiments. A brand new treatment strategy is provided for lung diseases such as acute lung injury, pulmonary fibrosis and the like which are characterized by ATII dry failure, the technical blank of intervention of natural active ingredients in ATII dry is filled up, a new way which is efficient, low in cost and easy to obtain is provided for ATII dry maintenance, the concentration of a medicine prepared from the natural active ingredients is screened, and the clinical application prospect is wide. An important theoretical basis is provided for further medication and medicine preparation, meanwhile, the pharmacological application range of the hederagenin is expanded, and a new target and a new strategy are provided for subsequent intervention treatment of lung diseases such as acute lung injury and pulmonary fibrosis needing injury repair.

The present invention discloses a biomarker, a detection reagent and its application related to diabetic retinopathy. The biomarker related to diabetic retinopathy includes circ_0053004, and the nucleotide sequence of circ_0053004 is shown in SEQ ID No. 1. In the present invention, the change in the expression level of circ_0053004 is significantly correlated with the occurrence of diabetic retinopathy. It can be used as a biomarker for the early diagnosis of diabetic retinopathy, regularly assessing the progression of diabetic retinopathy and the recurrence after treatment, and providing an important reference basis for the early diagnosis, prognosis and early intervention treatment of diabetic retinopathy. It has great practical clinical value, can intervene and treat early, and reduce unnecessary treatment and expenses for patients who are not at high risk of recurrence.

This application discloses a multi-channel stimulation abnormal gait intervention and correction system and electronic equipment, relating to the field of smart medical technology. The system includes: a sensor that collects the target subject's gait data in real time during the abnormal gait intervention treatment process; a control terminal that calculates the target subject's current gait cycle information in real time based on the gait data at preset time intervals, predicts the target subject's step start time, and determines rhythmic audio that is in sync with the current gait cycle information; an audio rhythm intervention terminal that plays rhythmic audio to the target subject; a pressure and muscle electrical stimulation intervention terminal that applies pressure and electrical stimulation to the target subject's thigh corresponding to the step at the target subject's step start time; and virtual reality glasses that display a virtual model of a medical staff member in the front right of the virtual field of view, and through the virtual model of the medical staff member, outputs step guidance information in the form of voice and / or action to the target subject at the target subject's step start time. This solution improves the intervention effect of abnormal gait.

A method and system for determining a risk of an infection for a patient is disclosed. In one embodiment, the system and method includes extracting patient data from one or more databases corresponding to a pool of patients under treatment; using the extracted patient data with one or more predictive models to generate a respective patient risk score for each patient in the pool of patients for developing an infection within a selected time period; generating a report including at least a portion of an identified subset of the pool of patients and their respective patient risk scores; and transmitting the report to one or more healthcare institutions that further identify one or more patients from the portion of the identified subset of the pool of patients for an intervention treatment, consultation, training, or a combination thereof.

The application discloses a gait intervention method for a dyskinesia disease population, a music generation method, device, system, equipment and medium, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process that a target object suffering from a dyskinesia disease is intervened and treated according to abnormal gait by rhythm music, collecting multi-modal physiological data of the target object in real time, and dynamically determining a plurality of motion symptom characteristic indexes related to gait of the target object according to the multi-modal physiological data; determining music parameters at each moment in real time according to the plurality of motion symptom characteristic indexes; dynamically adjusting notes of the rhythm music at each moment according to the music parameters at each moment, and generating rhythm music adapted to the current gait condition of the target object. According to the scheme, the rhythm music can be more comprehensively and individually dynamically adjusted, and is more suitable for the current gait condition of the target object, so that the effect of abnormal gait rehabilitation treatment, intervention and correction can be improved.

The invention relates to the field of bronchial interventional therapy, in particular to bronchial interventional medicine accurate pushing equipment which comprises a lantern ring sealing tile, a hinge part is arranged on one side of the outer arc face of the lantern ring sealing tile, and the lantern ring sealing tile is connected with an annular base disc through the hinge part of the outer arc face. A deformation cavity of the built-in guide sleeve is filled with the outer arc face of the medicine storage bag and tightly attached to the inner inclined end, a contact face gap is filled with a reserved cavity of the elastic blocking piece, and the sealing gasket is extruded through cooperation with the fastening nut to form port sealing. In the dosing process, a clamping structure of a conical clamping block and an external guide sleeve is combined with a hinged fixed elastic blocking piece of an annular base disc of a lantern ring sealing tile to synchronously reinforce sealing of a contact surface, so that liquid medicine is effectively prevented from being stored; a leakage path in the pushing and resetting process not only avoids medicine dosage loss and ensures that the medicine amount delivered to a lesion area reaches an expected treatment standard, but also prevents local stimulation or adverse reaction caused by the fact that leaked liquid medicine makes contact with normal tissues of the bronchial tube, and the treatment risk of a patient is reduced.

The invention provides an application of plasma proteomic biomarkers in prognosis evaluation related to long-term life quality of severe novel coronavirus infected patients, and relates to the technical field of biomedicines.The biomarkers comprise CAT, ARCN1, KRT5 and CTSC, and the prognosis evaluation related to the long-term life quality of the severe novel coronavirus infected patients is evaluated through plasma proteomic spectra of the severe novel coronavirus infected patients before MSC treatment. And screening to obtain the potential biomarker for predicting the long-term response of MSC treatment. High-risk crowds with long-term sequelae are identified through the protein biomarker region, the life quality level of a patient after MSC treatment for one year can be accurately predicted, patients more likely to benefit from MSC treatment can be identified, clinical doctors are helped to select applicable crowds before early intervention treatment and MSC infusion, and the clinical experience is improved. And improvement of life quality and long-term prognosis of patients suffering from severe novel coronavirus infection in the rehabilitation period is facilitated.

The invention relates to the technical field of biological medicine, in particular to application of 4-VPS in preparation of a kit for screening and / or diagnosing hypertensive kidney injury. According to the invention, a detection sample of 4-VPS is peripheral blood, and the sample is convenient to collect, minimally invasive and easy to popularize clinically; meanwhile, functional experiments prove that 4-VPS can directly induce kidney injury, early diagnosis of hypertensive nephropathy is achieved through 4-VPS, a patient can receive intervention treatment in the early stage of the disease, the disease is delayed or even prevented from developing into the end-stage nephropathy, the requirement of the patient for subsequent dialysis treatment or kidney transplantation is reduced, personal medical expenditure is reduced, and the treatment cost is reduced. Meanwhile, consumption of social medical resources is reduced, and remarkable economic benefits are achieved.

The invention discloses a transcranial electrical stimulation system and method for relieving skin reaction, and belongs to the field of medical auxiliary equipment. Single-electrode stimulation signals are decomposed into multi-electrode stimulation signals to be output, so that space treatment field distribution formed by the multi-electrode stimulation signals is equivalent to space treatment field distribution formed by the single-electrode stimulation signals, and skin reaction below the stimulation electrodes is relieved; wherein stimulation parameters of electrical stimulation are obtained by simulating and solving a head model electric field established by real data. The method can be used for relieving the skin reaction of a patient receiving transcranial electrical stimulation intervention treatment, so that the tolerance of an individual subjected to treatment intervention is improved.

The invention belongs to the technical field of biomedical instruments, and particularly relates to a photoelectric collaborative intervention orthokeratology lens for improving myopia, which comprises an external transmitting end, an internal receiving end and an orthokeratology lens, the external transmitting end and the internal receiving end are interconnected through electromagnetic coupling, the orthokeratology lens is arranged below the internal receiving end, and the external transmitting end is connected with the internal receiving end through electromagnetic coupling. And the receiving end is tightly attached to the internal receiving end. A wireless first ring layer of an internal receiving end is designed into two matching circuits, and through a first chip capacitor and a second chip capacitor which are arranged at an external receiving end, and under the combined action of a third chip capacitor, a fourth chip capacitor and a chip rectifier which are arranged at the internal receiving end, the wireless first ring layer is matched with the two matching circuits; resonance frequency points of the wireless receiving coil and the metal coil are controlled to be 44.5 MHZ, so that LED light emitting and electric field generation are realized for intervention treatment stimulation treatment. By combining the matching circuit and the orthokeratology lens, improvement of myopia is accelerated, and discomfort and risks caused by long-time wearing of the orthokeratology lens are reduced.

The application provides an intervention method, device, electronic equipment and storage medium for deep brain stimulation, wherein the intervention method comprises: acquiring an electroencephalogram signal of a target user, determining an electroencephalogram feature set of the electroencephalogram signal, determining intervention-related information for the target user based on the electroencephalogram feature set, and performing intervention processing according to the intervention-related information. In this way, when the DBS intervention is performed, the intervention-related information suitable for the patient's disease condition can be automatically selected according to the electroencephalogram feature of the patient, so that the effect of precise intervention treatment is achieved.

The application provides application of levosulpiride in preparation of a medicine for treating pulmonary arterial hypertension, and the medicine comprises levosulpiride as an active ingredient. Through a pulmonary arterial hypertension model of a rat, the application gives an intervention treatment of levosulpiride, and the effect of levosulpiride on pulmonary vessels is determined: the levosulpiride can reduce the mean pulmonary arterial pressure of a pulmonary arterial hypertension rat, reduce pulmonary vascular resistance, and improve right ventricle and pulmonary vessel remodeling, thereby providing a strategy for developing the medicine for treating the pulmonary arterial hypertension.