146 results about "Intervention treatment" patented technology

The invention relates to the technical field of medical image processing and computer vision, and discloses a lightweight lung CT image super-resolution method based on multi-scale feature adaptive aggregation. The lightweight lung CT image super-resolution method based on multi-scale feature adaptive aggregation comprises the following steps: S1, a shallow feature extraction stage: extracting low-level features in a low-resolution lung CT image through an initial convolutional layer; s2, in a deep learning network MHAG-Net stage, deep features of the lung CT image are extracted, and image detail expression is enhanced; according to the lightweight lung CT image super-resolution method based on multi-scale feature adaptive aggregation, the resolution and detail quality of the reconstructed image can be remarkably improved, a doctor can more accurately evaluate the lung injury degree of a patient and intervene treatment in time, and the method can be widely applied to the field of medical image processing and has a wide application prospect. Particularly, the method has a wide application prospect in the aspects of super-resolution reconstruction, focus detection, fine structure analysis and the like of the lung CT image.

The invention discloses a gait intervention method, a music generation method, a device, a system, equipment and a medium for people suffering from dyskinesia diseases, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process of performing abnormal gait intervention treatment on a target object suffering from dyskinesia according to rhythmic music, acquiring multi-modal physiological data of the target object in real time, and dynamically determining a plurality of gait-related movement symptom characteristic indexes of the target object according to the multi-modal physiological data; determining music parameters at each moment in real time according to the multiple exercise symptom characteristic indexes; and dynamically adjusting notes of the rhythmic music at each moment according to the music parameters at each moment, and generating the rhythmic music adaptive to the current gait condition of the target object. According to the scheme, the rhythm music can be dynamically adjusted more comprehensively and individually, the current gait condition of the target object can be better met and adapted, and the effect of abnormal gait rehabilitation treatment, intervention and correction can be improved.

The invention discloses a biomarker composition and application thereof in predicting gastric cancer risk. Specifically, the invention discloses application of a biomarker combination in preparation of a kit for predicting and / or diagnosing gastric cancer. Wherein the biomarker combination is composed of 145 kinds of biomarkers, and the kit comprises a reagent for detecting the expression level of the biomarkers in the biomarker combination. The biomarker combination has the advantages of high sensitivity and high specificity in prediction of gastric cancer risk, provides favorable technical support for prediction of occurrence and development of gastric cancer, has wide scientific research value, and provides great convenience for early clinical diagnosis, intervention treatment and the like.

The invention relates to a voice disorder detection method, device and equipment and a readable storage medium. The method comprises the following steps: acquiring a standard audio-visual material, responding to a pronunciation operation of a to-be-detected object on the standard audio-visual material, acquiring multi-modal pronunciation data, extracting audio acoustic features based on the pronunciation audio, extracting video visual features based on videos of facial and oral activities, and displaying the extracted audio acoustic features and the extracted video visual features. And performing multi-modal feature fusion on the audio acoustic features, the video visual features and the demographic information coding data to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, obtaining a voice obstacle detection result of the to-be-detected object. Compared with the prior art, according to the embodiment of the invention, through multi-modal feature fusion, the accuracy and comprehensiveness of voice disorder detection can be improved, the diagnosis efficiency can be improved, the dependence on professionals can be reduced, the burden of medical resources can be reduced, the specific type of pronunciation problems can be clarified, and a scientific basis can be provided for subsequent personalized intervention treatment.

The invention belongs to the technical field of molecular biology, and particularly provides a biomarker for traumatic brain injury detection, the biomarker comprises NSE and GFAP, and preferably further comprises at least one of S100B, UCH-L1, P-tau and IL-6. On the basis of the biomarker, a reagent card, a kit, a system and other traumatic brain injury assessment products are provided, a rapid and non-invasive assessment alternative scheme is provided for traumatic brain injury, and assistance is provided for early intervention treatment. The radiation exposure risk of the patient is reduced, the diagnosis process is accelerated, and the illness state can be evaluated more comprehensively. Biomarkers are used in combination with the clinical severity of TBI and therapeutic care pathways, enabling better identification and hierarchical management of mild and severe patients. The biomarkers of the invention can provide extremely significant and highly credible test results for specific patient populations requiring admission treatment or at different clinical severity.

The invention discloses a biomarker combination and application thereof in predicting bladder cancer risk. Specifically, the invention discloses application of a biomarker combination in preparation of a kit for predicting and / or diagnosing bladder cancer. The biomarker combination is composed of 76 biomarkers, and the kit comprises a reagent for detecting the expression level of the biomarkers in the biomarker combination. The biomarker combination disclosed by the invention has the advantages of high sensitivity and high specificity in predicting the risk of bladder cancer, provides favorable technical support for predicting the occurrence and development of bladder cancer, has wide scientific research value and provides great convenience for early clinical diagnosis, intervention treatment and the like.

The invention discloses an abnormal gait intervention correction method, a music generation method, a device, a system, equipment and a medium, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: in the process of performing abnormal gait intervention treatment on a target object according to rhythmic music, acquiring multi-modal physiological data of the target object in real time, and determining multi-dimensional emotional characteristics and body physiological characteristics of the target object according to the multi-modal physiological data; based on the emotion features and the body physiological features, music parameters at each moment are determined according to the multi-modal physiological data and gait parameters; and according to the music parameter at each moment, dynamically generating rhythmic music adapted to the current physiological state of the target object. According to the scheme, multi-dimensional collaborative optimization of the rhythmic music is realized, the individuation and emotion expression of the rhythmic music are improved, and the synchronization rate of gait motion-hearing is improved.

The invention discloses an AI-based atrial fibrillation patient health risk prediction method, and belongs to the technical field of medical information, and the method specifically comprises the steps: receiving a physiological parameter record and an intervention treatment record of an atrial fibrillation patient, carrying out the time sequence alignment operation, and forming structured patient data; extracting risk-related features from the structured patient data, wherein the risk-related features are divided into basic risk features and intervention response features; inputting the basic risk features into a basic risk prediction network, and outputting a basic risk score; inputting the intervention response characteristics and the basic risk score into an intervention effect separation network together to generate a post-intervention risk score; calculating a net effect value of treatment intervention according to the difference between the basic risk score and the post-intervention risk score; combining the basic risk score, the post-intervention risk score and the net effect value to generate a patient individualized long-term risk prediction trajectory; and accurate prediction of the long-term health risk of the atrial fibrillation patient is realized.

The invention belongs to the technical field of p300 and fnirs intervention treatment, and particularly relates to a p300 and fnirs technology-based quantitative evaluation system and method for the curative effect of movement intervention on undergraduate depression, a data acquisition module is connected with a movement intervention module and receives data information generated in the movement intervention process, and a central processing module is connected with the data acquisition module and receives the data information generated in the movement intervention process. The intervention effect evaluation module is used for receiving data information transmitted by the data acquisition module and analyzing the data information acquired by the data acquisition module in real time, the intervention effect evaluation module is connected with the central processing unit, p300 and fnirs data are combined with a psychological evaluation tool such as a depression scale result, the curative effect of exercise intervention on depression is comprehensively evaluated, p300 and fnirs technologies are combined, and the intervention effect is evaluated. By comprehensively analyzing the electroencephalogram physiological data and the hemodynamic data, quantitative evaluation on the depression curative effect of the college students through exercise intervention is provided, and the comprehensive evaluation method not only can improve the evaluation precision of the intervention effect, but also can provide a scientific basis for formulating a personalized treatment scheme.

The invention discloses an application of sIL-2R alpha as a marker in a product for early prediction of acute respiratory distress syndrome. The product for early predicting the acute respiratory distress syndrome comprises a reagent or a medicine for detecting the expression level of sIL-2R alpha in a patient with the acute respiratory distress syndrome. The sIL-2R alpha is used as a biomarker, and experiments prove that the sIL-2R alpha level of the plasma of the ARDS patient is obviously higher than that of a patient without ARDS in the plasma of the ARDS patient. By detecting the sIL-2R alpha level of plasma or serum of an ARDS patient, the ARDS occurrence risk is predicted in an early stage, so that individualized intervention treatment is given, the occurrence rate of ARDS can be reduced, and the kit has important clinical application value for improving prognosis of the ARDS patient.

The invention belongs to the technical field of biology, and particularly relates to application of a biomarker BIG1 to preparation of a reagent for diagnosing or monitoring sepsis immunosuppression. According to the invention, BIG1 expression in peripheral blood mononuclear cells is used as a biomarker to prepare a reagent for predicting sepsis immunosuppression, and by detecting the transcription or translation level of BIG1 in peripheral blood mononuclear cells or tissue macrophages, expression reduction indicates immune activation of sepsis patients, and expression increase indicates immunosuppression of sepsis patients. Therefore, individualized precise intervention treatment can be properly given, the treatment rate of sepsis is increased, reference information is provided for reasonable selection of treatment means and allocation of medical resources, and the method has important clinical application value in improvement of prognosis of sepsis patients.

The invention belongs to the technical field of medical health, and provides a precise intervention treatment system and method based on personalized nutrition metabolism assessment, and the system comprises a data collection module which is used for collecting the physiological data, nutrition intake data, gene information, microbiome data and lifestyle data of an individual; the metabolism evaluation module is used for inputting the data acquired by the data acquisition module into a metabolism evaluation model based on deep learning; the intervention scheme generation module is used for evaluating a result and an individual health target based on the metabolic condition; through joint cooperation of the data acquisition module, the metabolism evaluation module and the intervention scheme generation module, in combination with deep learning and a multi-objective optimization algorithm, the system can provide a more personalized and scientific health management scheme according to the specific condition of an individual, the health management effect and the success rate of disease intervention are improved, and the system is suitable for popularization and application. And powerful support is provided for individual health management and disease prevention.

The invention discloses an optimization method and device for an abnormal gait intervention treatment scheme, equipment and a medium, and relates to the technical field of intelligent medical treatment. The specific implementation mode comprises the steps that in the process of conducting abnormal gait intervention treatment on a target object, multi-modal physiological data and gait data of the target object are collected in real time; performing time sequence analysis on the multi-modal physiological data and the gait data within a preset duration, and dynamically and quantitatively evaluating the training state conversion condition of the target object; and if the training state conversion condition is that a training state type changes, optimizing related parameters of a current abnormal gait and rhythm intervention scheme, and generating a new abnormal gait and rhythm intervention scheme adaptive to the gait state and the physiological state of the target object to perform abnormal gait intervention treatment. According to the scheme, the individuation and adaptability of a new abnormal gait rhythm intervention scheme can be improved, and then the effect of abnormal gait intervention rehabilitation treatment can be improved.

The present invention belongs to the technical field of colorectal cancer efficacy evaluation, and particularly relates to a marker for evaluating the efficacy of colorectal cancer patients after astragalus polysaccharide intervention therapy and its application. The present invention first discovered that l ncRNA-CERNA3-201 can be used as an independent marker for predicting the efficacy of colorectal cancer patients after astragalus polysaccharide intervention therapy, and can be used as a drug development target to improve the therapeutic effect of colorectal cancer patients.

The invention relates to the technical field of cardiovascular disease health risk assessment and management, and discloses a cardiovascular patient group health assessment system based on diet and individual characteristics, which comprises a data acquisition module, an analysis and prediction module and a health assessment module. According to the cardiovascular patient group health assessment system based on diet and individual characteristics, a data acquisition module acquires a user data set, a data preprocessing unit identifies the user data set, a risk proportion unit calculates a disease risk ratio Hbfx, and a variable prediction unit calculates a disease prediction data set Fbyc; the health assessment module calculates a comprehensive influence data set Zhyx and comprehensively assesses the influence of significant variables of a user on CVD risks, analysis and assessment are more comprehensive and highly targeted, the health assessment module compares a reference data set according to the comprehensive influence data set Zhyx and judges and assesses corresponding scores, and the effect of early intervention and treatment of cardiovascular diseases is better.

The utility model belongs to the technical field of wound suturing devices, and particularly relates to a wound suturing device for a tumor interventional therapy operation. The number of the bonding pads is two, and the front sides of the bonding pads are fixedly bonded to the rear sides of the corresponding closing plates; the number of the positioning mechanisms is two, the positioning mechanisms are connected with the two closing plates respectively, and the same sides of the two closing plates are matched with the corresponding positioning mechanisms; the supporting assembly comprises two stabilizing rods and four first springs, the top ends of the stabilizing rods penetrate through the two closing plates respectively and are connected with the two closing plates in a sliding mode, and the two first springs located on the same side are arranged on the corresponding stabilizing rods in a sleeving mode. The wound is not easy to crack after being closed, the wound is conveniently sutured, the operation is convenient and fast, time and labor are saved, and the device is convenient for personnel to use.

The present disclosure relates to a speech disorder detection method, device, equipment and readable storage medium. By acquiring standard audio-visual materials, in response to the pronunciation operation of the to-be-detected object to the standard audio-visual materials, multi-modal pronunciation data is collected, audio acoustic features are extracted based on the pronunciation audio, video visual features are extracted based on the video of the face and oral cavity activity, the audio acoustic features, the video visual features and the demographic information coding data are fused to obtain a fusion feature vector, and based on the fusion feature vector and a pre-trained prediction model, a speech disorder detection result of the to-be-detected object is obtained. Compared with the prior art, the embodiment of the present disclosure can improve the accuracy and comprehensiveness of speech disorder detection, improve the diagnosis efficiency, reduce the dependence on professionals, reduce the burden of medical resources, and clearly determine the specific type of pronunciation problem, thereby providing a scientific basis for subsequent individualized intervention treatment.

The utility model discloses a post-operative nursing limb fixing device for coronary intervention through femoral artery, which relates to the technical field of medical instruments and comprises a lower mounting block and an upper mounting block, semi-cylindrical grooves are formed in the side walls of the lower mounting block and the upper mounting block, one side of the lower mounting block is connected with the upper mounting block through a hinge, a rotating unit is rotatably mounted in the grooves, and the rotating unit is connected with the lower mounting block through a hinge. The inflatable cushion is mounted on the rotating unit, the air release valve is mounted on the upper mounting block and the lower mounting block, and a control switch is mounted on the upper mounting block; the locking unit is mounted on one side, far away from the hinge, of the lower mounting block; the mounting rod is vertically mounted on the side, away from the groove, of the lower mounting block, a mounting hole is formed in the sickbed, and a limiting groove matched with the clamping block is formed in the bottom of the mounting hole. The problems that after existing coronary artery interventional therapy, the mode that ankles of corresponding lower limbs of a patient are fixed to a sickbed through a rope after an operation to keep the patient lying flat and the lower limbs straightened is tedious, and the lumbago of the patient is likely to be caused are solved.

The invention discloses an application of simvastatin in preparation of a medicine for treating post-traumatic stress disorder. According to the invention, a post-traumatic stress disorder model is firstly constructed, and a result shows that in post-traumatic stress disorder model animals, obvious core behavior characteristics such as fear memory overconsolidation and anxiety behavior enhancement are shown. When simvastatin is used for intervention treatment, the fear memory fading ability of the model animal is obviously improved, and the anxiety behavior is obviously relieved; behavior experiment comprehensive evaluation shows that the stiffness time of animals in a simvastatin treatment group is remarkably shortened, the standing time and distance proportion of an open arm of an elevated cross maze are remarkably increased, the total movement distance of an open field experiment is remarkably increased, and simvastatin can effectively relieve fear memory disorder and anxiety behaviors of post-traumatic stress disorder model animals.

The invention discloses a heart and cerebral vessel interventional therapy device for the department of cardiology, and relates to the field of interventional therapy, the heart and cerebral vessel interventional therapy device comprises a linear module track, a U-shaped mounting frame is movably mounted on the linear module track, a lifting plate is slidably mounted on the U-shaped mounting frame, a movable sliding table is slidably mounted on the lifting plate, and an interventional box is arranged on the bottom side of the movable sliding table; an intervention head is arranged at one end of the intervention box. According to the device, medical staff can be helped to carry out heart and cerebral vessel interventional therapy in the state of being far away from X-ray equipment, the medical staff can avoid direct radiation exposure in a shielding radiation room, the harm of radiation to the medical staff is greatly reduced, occupational injuries are reduced, and the treatment efficiency is improved. According to the device, alternate arrangement and use of the guide wire, the catheter and the stent conveying wire can be completed, interventional therapy of heart and cerebral vessels is achieved, meanwhile, the physical strength effect of medical staff in the operation process is lowered, and the medical staff can keep a good physical state to treat more patients.

The invention relates to the technical field of catheter fixing devices. The cardiology department clinical interventional therapy catheter fixing device comprises a binding assembly, a first connecting assembly is installed at one end of the binding assembly, a second connecting assembly is installed at the other end of the binding assembly, a limiting assembly is installed at the top of the binding assembly, and a fixing assembly is installed at the top of the binding assembly. The limiting assembly is connected with the fixing assembly and limits the fixing assembly. A binding bandage is bound on the body of a patient, a second fixing shaft slides into clamping grooves in two clamping arms, the second fixing shaft is fixed through the clamping grooves under the torsion action of a first torsion spring, and limiting plates on the inner sides of the clamping grooves can be clamped into limiting grooves in the outer wall of the second fixing shaft, so that the second fixing shaft is fixed. The friction force between the binding bandage and the skin of the patient can be increased through the multiple rubber sheets on the rubber belts at the two ends of the binding bandage, and therefore the installation stability of the binding bandage can be improved.

To provide a self-care system for stress-related diseases or mental health issues caused by stress.SOLUTION: In a system for self-care of mental health, the system causes an information processing terminal included in the system to provide a user with information of a plurality of therapeutic interventions based on psychotherapy registered in the system on a screen of the information processing terminal in a selectable manner, either sequentially or at any time, continuously for a certain period of time, and further to provide the user with information of a plurality of therapeutic interventions based on the psychotherapy newly registered in the system, either sequentially or at any time, continuously for a certain period.SELECTED DRAWING: Figure 1

The invention discloses an abnormal gait intervention correction method and device based on rhythmic auditory stimulation, electronic equipment and a medium, and relates to the technical field of intelligent medical treatment. The method comprises the steps that when abnormal gait intervention treatment is conducted on a target object according to rhythmic audio, inertial data of the two feet of the target object are collected in real time; taking the first preset duration as a time interval, calculating a temporary gait cycle rhythm according to the inertial data in each first preset duration, and obtaining a plurality of temporary gait cycle rhythms; a second preset time length is used as a time interval, a real-time gait cycle rhythm is calculated based on the at least two temporary gait cycle rhythms according to the second preset time length, and the second preset time length is larger than the first preset time length; and dynamically adjusting the rhythm of the rhythm audio according to the rhythm of the real-time gait cycle, and performing rehabilitation treatment on abnormal gaits based on the rhythm of the adjusted rhythm audio. According to the scheme, the rhythm of the audio can be scientifically, accurately and reasonably set, and the intervention effect of abnormal gaits can be improved.

The application discloses a kind of chronic coronary syndrome risk stratification methods based on coronary microcirculation resistance index, it is related to medical data processing technical field.The method comprises: the clinical characteristic data of patient to be evaluated is obtained;The clinical characteristic data is input into the preset risk stratification model, and the risk group of the patient to be evaluated is obtained according to preset split condition.The preset split condition determines the split priority by analyzing the nonlinear correlation and the degree of distinction of multidimensional feature data, and generates a multi-layer classification model by combining survival tree algorithm training.The application breaks through the limitation of single index evaluation, effectively captures the nonlinear interaction between clinical indicators, significantly improves the risk stratification accuracy, can accurately identify the very low risk and high-risk subgroup, avoid clinical over-treatment or insufficient intervention treatment, and the model has strong interpretability and is easy to promote clinically.

The application provides an intervention treatment controllable bending catheter, and relates to the technical field of medical catheters. The intervention treatment controllable bending catheter comprises a cannula, an adjusting assembly is installed on the cannula, a large fastening ring is threadedly connected to the front of the adjusting assembly, a stabilizing assembly is threadedly connected to the front of the large fastening ring, a rear section assembly is fixedly installed at the front of the stabilizing assembly, a plurality of middle section assemblies are installed at the front of the rear section assembly, and a connecting outer tube and a connecting inner tube are installed between adjacent middle section assemblies. In use, the front section assembly is inserted into a human body, the front section assembly, the middle section assemblies and the rear section assembly are in a non-forced connection state, the insertion into the human body is facilitated, after the insertion, the adjusting assembly and the large fastening ring are rotated to tighten the steel wire, the front section assembly, the middle section assemblies and the rear section assembly enter a forced connection state under the action of the steel wire, and the front section assembly, the middle section assemblies and the rear section assembly are integrated, thereby facilitating subsequent operation.

The present application relates to the field of medical informatization and remote diagnosis and treatment technology, and discloses a curative effect evaluation and remote follow-up platform for mammitis ultrasonic interventional treatment. The platform integrates the imageological changes, physiological parameter trajectories, operation records and follow-up feedback of patients through a data processing module. A window recognition module dynamically divides curative effect observation windows and conventional observation windows according to treatment and feedback time points. A patient clustering module clusters patients based on the timing mode of physiology and images within the curative effect window, and identifies different response modes. A feature extraction module extracts typical operation features and follow-up response baselines of each patient community accordingly. A strategy generation module calculates the multidimensional matching degree by matching new patient data with the feature baselines of each community, and generates individualized follow-up strategies, thereby realizing adaptive and accurate definition of the curative effect evaluation window and individualized and directional optimization of follow-up management.

The invention provides a digital health index data management method and management system, and belongs to the technical field of digital therapy, and the method comprises the steps: generating at least one index for a specific disease to be treated in the digital therapy according to the disease; based on the generated at least one index for the disease, obtaining a calculation rule of the index; performing calculation processing on the collected index related data according to the calculation rule to obtain a calculation processing result and outputting the calculation processing result; the system comprises an index generation module, a calculation rule acquisition module and a data calculation processing module. According to the invention, the patient data collected by the digital therapy can be effectively utilized, and the adjustment of the intervention scheme of the digital therapy can be guided, so that the intervention treatment effect of the digital therapy can be improved.

The invention provides preparation and application of a kidney dual-targeting black phosphorus nano platform for treating acute kidney injury. Firstly, black phosphorus nanosheets and NH2-PEG-NH2 are mixed and then dispersed into deionized water, centrifugation is repeated, supernate is discarded, and a BP-PEG solution is obtained; kim-1 targeted polypeptide LTH powder is dissolved in deionized water, then EDC and NHS are added for a light-shielding reaction, a BP-PEG solution is added, light-shielding stirring is continued to obtain a BP-PEG-LTH mixture, then 4-octyl itaconic acid is added, then a PBS solution is added, light-shielding magnetic stirring is carried out, and the kidney double-targeting black phosphorus nano platform is obtained. The kidney dual-targeting black phosphorus nano platform is used as an intravenous injection for treating acute kidney injury, oxidative stress can be rapidly and effectively inhibited, inflammation is resisted, intercellular burial is promoted, malignant development of AKI is inhibited to a great extent, and the purpose of short-term specific intervention treatment after AKI is achieved.

The invention discloses a novel application of hederagenin in preparation of a medicine for maintaining the dryness of alveolar II epithelial cells, the hederagenin is definitely used for preparing the medicine for maintaining the dryness of the alveolar II epithelial cells for the first time, and the repairing effect of the hederagenin on ATII dry damage is verified through in-vivo and in-vitro experiments. A brand new treatment strategy is provided for lung diseases such as acute lung injury, pulmonary fibrosis and the like which are characterized by ATII dry failure, the technical blank of intervention of natural active ingredients in ATII dry is filled up, a new way which is efficient, low in cost and easy to obtain is provided for ATII dry maintenance, the concentration of a medicine prepared from the natural active ingredients is screened, and the clinical application prospect is wide. An important theoretical basis is provided for further medication and medicine preparation, meanwhile, the pharmacological application range of the hederagenin is expanded, and a new target and a new strategy are provided for subsequent intervention treatment of lung diseases such as acute lung injury and pulmonary fibrosis needing injury repair.

The present invention discloses a biomarker, a detection reagent and its application related to diabetic retinopathy. The biomarker related to diabetic retinopathy includes circ_0053004, and the nucleotide sequence of circ_0053004 is shown in SEQ ID No. 1. In the present invention, the change in the expression level of circ_0053004 is significantly correlated with the occurrence of diabetic retinopathy. It can be used as a biomarker for the early diagnosis of diabetic retinopathy, regularly assessing the progression of diabetic retinopathy and the recurrence after treatment, and providing an important reference basis for the early diagnosis, prognosis and early intervention treatment of diabetic retinopathy. It has great practical clinical value, can intervene and treat early, and reduce unnecessary treatment and expenses for patients who are not at high risk of recurrence.