The invention relates to a preparation method of a
simvastatin tablet. The
simvastatin tablet is composed of
simvastatin, an acidic protecting agent, an
antioxidant agent, a filling agent, a disintegrating agent and a
lubricant. The preparation method disclosed by the invention comprises the following steps: carrying out low-temperature
superfine grinding on a simvastatin
raw material and
lactose in a weight ratio of 1 to (1-10), so that the particle size is reduced and the specific surface area is increased, and then the
raw material is changed from a lipophilic material into a hydrophilic material; uniformly mixing the obtained mixed material with the acidic protecting agent and the
antioxidant agent, the rest of
lactose,
microcrystalline celluloses and crosslinked
carboxymethyl cellulose sodium, granulating by using a wet method, and carrying out fluidized
drying while controlling the
water content of a finished product grains at 1-5%, so that the simvastatin tablet is prepared. The prescription process is simple and easy to control, and prepared preparation is good in content uniformity, high in
dissolution rate, good in absorption, and high in
bioavailability in comparison with other preparations. The preparation method of the simvastatin tablet disclosed by the invention is good in good in reproducibility, large in productivity, and stable and controllable in quality, and can effectively guarantee the effectiveness of drugs and the safety of
drug application of patients.