14 results about "Pravastatin" patented technology

A method for detecting pravastatin-related substances. The detection method comprises the following steps: detecting a sample to be detected by means of using a high-performance liquid chromatography method, wherein the packing material of the chromatographic column for the liquid chromatography is ethylenebridge hybrid particles; a five-stage gradient elution is used in the high-performance liquid chromatography, and said sample comprises one or more of pravastatin, a salt of pravastatin and pravastatin-related substances. The detection method can simultaneously realize the effective separation of pravastatin from adjacent unknown degradation impurities thereof and impurity D from adjacent unknown impurities thereof, enabling accurate detection of pravastatin and impurity D, and it can also improve the resolution between impurity B and impurity E. Moreover, the detection method has passed methodological validation, thereby providing an effective method for detecting the content of pravastatin-related substances.

A method is provided for treatment of atherosclerotic cardiovascular disease in a subject in need thereof by administering a statin pharmaceutical composition to the subject when the subject is qualified for over-the-counter access to the statin pharmaceutical composition. In some embodiments, the statin pharmaceutical composition includes atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin as an active ingredient.

A method of treating a wound may include topically administering a statin composition including a statin selected from atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combination thereof. The statin composition may be administered in an ointment, powder, or liquid format. The method may also include topically administering one or more antimicrobial drugs.

The invention belongs to the technical field of biological catalysis, and relates to a light-driven P450 catalytic system and application thereof in pravastatin synthesis. The system comprises a thylakoid membrane, Fdx, P450sca-2 and PC / Cyt C6, and is characterized in that the PC / Cyt C6 is connected with the Fdx; the thylakoid membrane takes H2O as an electron donor under an illumination condition, electrons are generated through a light system II, and the electrons are sequentially transferred to Fdx and are conveyed to P450sca-2 through interaction between proteins to catalyze an enzymatic reaction. According to the invention, light energy and / or water are / is used as an energy source and an electron source, expensive NAD (P) H is completely or partially replaced, and the production cost is greatly reduced. The system lays a certain foundation for constructing a P450 reaction system for photosynthesis and CO2 fixation in the future.

: The present invention provides a topical pharmaceutical composition comprising Janus kinase (JAK) inhibitors like Tofacitinib, Immunosuppressive agent like Tacrolimus, Fingolimod and statins like atorvastatin, Simvastatin, Fluvastatin, Lovastatin, Pitavastatin, Pravastatin and Rosuvastatin dissolved or dispersed in a pharmaceutically acceptable base together with other pharmaceutically acceptable excipients or in a dermatologically acceptable carrier, useful in the treatment of vitiligo. The inventive concept provided herein are methods and pharmaceutical compositions by preparing oral dosage forms like Topical liquid spray or Topical cream or Topical gel dosage form for the management of vitiligo and its associated disorders and accordingly performing preclinical study to prove the efficacy of the selected drug substances from the class of JAK inhibitors, statins and immunosuppressants.

Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

Treatment of cerebral arterial thrombosis with pravastatin is disclosed. The pravastatin adopts an inhalation administration mode or targeted pulmonary administration, so that the aggregation of the medicine in the lung can be enhanced, the infiltration of brain immune cells can be inhibited, the inflammation of the brain parenchyma stroke part can be alleviated, the injury of the nervous system of the stroke part can be improved, and the recovery of the damaged nerve function can be promoted.

The invention relates to a method for detecting related substances of pravastatin. The detection method comprises the following steps that a to-be-detected product is detected through a high performance liquid chromatography method, and a filler of a chromatographic column of the liquid chromatography method is ethylidene bridge hybrid particles; according to the high performance liquid chromatography method, brand new five-stage gradient elution is adopted, and a to-be-detected product comprises one or more of pravastatin, pravastatin salt and pravastatin related substances. According to the detection method, effective separation of pravastatin and unknown degradation impurities adjacent to pravastatin and effective separation of an impurity D and unknown impurities adjacent to pravastatin can be achieved at the same time, and accurate detection of pravastatin and the impurity D can be achieved; the separation degree of the impurity B and the impurity E can be improved; the detection method also passes methodology verification, and an effective detection method is provided for the content of the pravastatin related substances.

A method of treating a wound may include topically administering a statin composition including a statin selected from atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combination thereof. The statin composition may be administered in an ointment, powder, or liquid format. The method may also include topically administering one or more antimicrobial drugs and / or naltrexone.

The present invention relates to a modified metal, a preparation method thereof and an application. The modified metal comprises a metal and a film layer located on the surface of the metal. Among them, the metal comprises one or more of titanium, tantalum, and magnesium, and the film layer comprises a statin compound, and the statin compound comprises one or more of simvastatin, pravastatin, atorvastatin, and rosuvastatin. The modified metal of the present invention has good antibacterial properties and can effectively avoid the infection of the orthopedic implants produced.

A measurement method for a pravastatin-related substance. The measurement method comprises the following steps: using a high-performance liquid chromatography method to measure a product to be measured, wherein a filler of a chromatography column of the liquid chromatography method is ethylene bridged hybrid particles, and said product comprises one or more of pravastatin, a pravastatin salt and a pravastatin-related substance. The measurement method can achieve effective separation of pravastatin and adjacent unknown degradation impurities, and impurities D and adjacent unknown impurities simultaneously, can achieve accurate measurement of the pravastatin and the impurities D, is easy to operate and control, has an accurate measurement result, and can further achieve effective separation of impurities B and impurities E, thereby improving the accuracy of measuring the amounts of the pravastatin, the impurities D, the impurities B and the impurities E, and providing an effective measurement method for the amount of the pravastatin-related substance.

Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

A method of treating a wound may include topically administering a statin composition including a statin selected from atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, or combination thereof. The statin composition may be administered in an ointment, powder, or liquid format. The method may also include topically administering one or more antimicrobial drugs and / or naltrexone.

A method is provided for treatment of atherosclerotic cardiovascular disease in a subject in need thereof by administering a statin pharmaceutical composition to the subject when the subject is qualified for over-the-counter access to the statin pharmaceutical composition. In some embodiments, the statin pharmaceutical composition includes atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin as an active ingredient.