86 results about "Intraocular pressure" patented technology

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention relates to the technical field of intelligent medical treatment, and discloses a cataract surgery navigation control method based on multi-modal fusion, which comprises the following steps: carrying out lightweight preprocessing on an eye fundus image, ultrasonic probe data, a corneal topographic map and intraocular pressure parameters through an edge computing architecture, and constructing an efficient feature extraction network by adopting a knowledge distillation technology; self-adaptive feature fusion is realized based on an uncertainty quantification mechanism, real-time structure recognition is provided by utilizing an augmented reality technology, an intelligent navigation strategy is generated by pre-training a reinforcement learning model, an instrument control system with multilayer safety guarantee is established, and continuous optimization of the system is realized by adopting an online learning mechanism. According to the invention, the precision and safety of the operation are effectively improved, and an effective technical scheme is provided for intelligent navigation control of the cataract operation.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention discloses a dioptric scleroderma cataract dynamic intraocular pressure stable control ultrasonic emulsification system adaptive to a dual-channel operation, which comprises a host control unit, an ultrasonic emulsification handle, a perfusion and suction system, an intraocular pressure monitoring unit, a pressure balance module and a scleroderma fragmentation module, through cooperation of the intraocular pressure control module and the two-way operation type adaptive control module, a high-precision filling valve and a closed-loop suction pump are synchronously adjusted in real time according to anterior chamber built-in and external monitoring fusion data, and intraoperative intraocular pressure fluctuation is controlled within + / -2 mmHg; through pulse modulation and a self-adaptive negative pressure curve of the hardcore fragmentation enhancement module, the stability of the anterior chamber is ensured while the hardcore fragmentation efficiency is improved; fluid dynamics and energy parameters can be automatically optimized according to conventional incisions or micro incisions; according to the system, the anterior chamber stability problem in the high-difficulty cataract surgery is solved.

The invention discloses an eye vision light health management system, and relates to the technical field of vision health management systems, the system specifically comprises data management and service management, the data management comprises a data acquisition module, a data processing module, a data identification module and a data transmission module, and the service management comprises tour service, store arrival service and remote service. According to the eye vision light health management system, through cooperation of the data acquisition module, the data processing module, the data identification module and the data transmission module, a detection mode of integrating intelligent wearable equipment and an eye vision light detection instrument to detect key indexes of vision data, intraocular pressure and diopter of a patient is adopted, a single detection mode is replaced, and meanwhile, the detection efficiency is improved. The integration of the intelligent wearable device and the eyesight light detection instrument also saves the step of manual recording of the detection data by the staff, thereby improving the accuracy of the eyesight detection data of the patient.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention relates to the technical field of intraocular pressure measurement, and discloses an artificial eyeball and an intraocular pressure monitoring simulation platform and method. The method comprises the following steps: controlling a water pressure regulator to regulate water pressure in a water injection pipeline and an artificial eyeball according to an intraocular pressure data model; a pressure sensor in the artificial eyeball senses and obtains a pressure electric signal in the artificial eyeball in real time; the pressure electric signal is transmitted to a transmitting coil through a signal wire, and the transmitting coil transmits the pressure electric signal to a receiving coil outside the artificial eyeball through mutual inductance; the receiving coil and the transmitting coil are in mutual inductance communication to receive and obtain a pressure electric signal, and the signal acquisition device acquires the pressure electric signal of the receiving coil to obtain an intraocular pressure measurement value; the actual intraocular pressure value is obtained by conducting signal collection on the water pressure sensor. By applying the system, the function of simulating the adjustable aqueous humor pressure and the blinking action can be achieved, high integration and intelligence are achieved, and accurate control and real-time monitoring of the change of the internal pressure of the simulated eyeball can be achieved.

A biosensor includes a periodic crystalline structure first layer, and an amorphous crystalline structure second layer. The first and second layers are formed from a biocompatible silicone having a Young's Modulus E between 0.4 and 2.0 MPa. The biosensor has a pressure dependent NIR resonance peak shift of less than 15 nm over a field of view of 40°, and has an optical pressure sensitivity of between 0.38 and 2.6 nm / mm Hg. The biosensor may be formed by forming a 3D crystalline structure having a periodic amorphous crystalline first layer and an amorphous crystalline second layer. Voids of the 3D crystalline structure are filled with the biocompatible silicone / polydimethylsiloxane a material. The 3D crystalline structure is removed to form an inverse structure having a first volume of an amorphous arrangement of voids and a second volume of a periodic arrangement of voids.

The present disclosure discloses a fluid collection box for phacoemulsification surgery, including a case composed of a front plate, a body, and a rear plate. The case communicates with a waste liquid bag. The body has a perfusion passage and a suction passage that are disposed independently. The perfusion passage is a sealed circulation cavity defined by a cover and the body. The circulation cavity communicates with a first connection port and a second connection port on the body for perfusion. There is a gap between the cover and the body. Connection and disconnection of the perfusion passage is controlled by pressing the cover. The suction passage is a pipeline that communicates a third connection port with the waste liquid bag, and performs perfusion by a peristaltic pump. The suction passage further communicates with a negative pressure regulating loop, to regulate pressure within the suction passage. According to the present disclosure, the perfusion passage and the suction passage are independently disposed, so that the two do not interfere with each other and work independently. Meanwhile, it is ensured that pressure within the perfusion passage is stable, thereby reducing changes of intraocular pressure, and improving safety during use.

An insertion device for an ocular implant for regulating intraocular pressure includes a cannula having an internal space for receiving at least a portion of an ocular implant having a stent and an implant opening for inserting the ocular implant; a handle configured to be connected to the cannula and held by a surgeon; and a holder configured to be coupled to the handle and including a receiving portion configured to receive the stent of the ocular implant. The ocular implant insertion device appropriately fixes the stent inserted into the tube of the ocular implant in a manner attached to the insertion device, thereby preventing problems such as the stent coming out of the tube, the implant being separated from the insertion device by the stent, or the stent obscuring the surgeon's field of vision during implant implantation surgery.

The present disclosure generally relates to devices for pressure sensing and drug delivery applications. In some aspects, devices comprising a reservoir in fluidic communication with a channel defined between two deformable polymer lenses are provided. In some embodiments, the reservoir contains a scaffold configured to reversibly absorb or release a fluid into the channel in response to a volume change of the reservoir, for example, due to an applied external pressure. In some cases, the distance traveled by the fluid is proportional to the change in volume of the reservoir. Other aspects of the disclosure relate to methods of using such devices. For example, in some embodiments, the methods relate to determining an intraocular pressure within an eye of a subject, for example, suspected of having an eye disease or disorder.

The invention discloses a modular integrated rapid ophthalmology screening vehicle and an examination method thereof, and relates to the technical field of ophthalmology examination. The inspection mechanism is mounted on the rear side of the bottom inner wall of the screening vehicle body; the two shading mechanisms are mounted between the top inner wall and the bottom inner wall of the screening vehicle body; through cooperative work of the vision detection module, the fundus imaging module, the intraocular pressure detection module, the slit lamp module and the AI auxiliary diagnosis module, and efficient interconnection between equipment in each module and the host server through USB-C and HDMI dual interfaces with unified specifications, the functional modules can be flexibly increased or decreased according to requirements of different screening scenes; the problems that a traditional whole machine integrated device is complex in structure and large in deployment difficulty are solved, multi-dimensional detection such as refraction detection, fundus imaging and intraocular pressure measurement can be completed through professional devices of all the modules, the screening efficiency and diagnosis accuracy are greatly improved, and the coverage range of ophthalmology screening service is effectively expanded.

The invention discloses a multi-mode simulation device and method for intraocular pressure. The simulation device comprises a track vertically arranged on the base table, a clamp is connected to the track in a sliding mode, a first liquid storage pipe with an opening in the top is installed on the clamp, the first liquid storage pipe is connected with a second liquid storage pipe through a flexible connecting pipe, and the first liquid storage pipe, the second liquid storage pipe and the flexible connecting pipe are filled with testing liquid; a temperature control module comprising a temperature sensor and a heater is arranged on the outer wall of the second liquid storage pipe; a simulated intraocular pressure measuring end is arranged at the top of the second liquid storage tube; and a distance measurement display module is arranged right above the first liquid storage pipe. The problems of mechanical pressure drifting and slow dynamic response are solved while intraocular pressure simulation precision and dynamics are guaranteed, multi-mode pressure control is achieved, practicability is high, a reliable platform is provided for medical instrument testing and pathological research, and animal experiments can be effectively replaced.

The present invention provides an intraocular pressure measurement method and system based on ultrasound and deep learning. The method includes: collecting ocular ultrasound data and intraocular pressure data; performing four-dimensional ultrasound reconstruction on the continuously collected ultrasonic intraocular pressure data sequence to obtain four-dimensional ultrasound data reflecting the three-dimensional dynamic changes of the internal structure of the eye; establishing a relationship model between the four-dimensional ocular ultrasound data and the corresponding intraocular pressure data; constructing and training an LSTM neural network intraocular pressure recognition model based on the reconstructed four-dimensional ocular internal structure ultrasound data, intraocular pressure data, and the relationship model; and identifying and displaying the patient's intraocular pressure based on the trained LSTM neural network intraocular pressure recognition model. By establishing a relationship model between the four-dimensional ocular ultrasound data and the corresponding intraocular pressure data, the present invention mines ultrasound data features closely related to intraocular pressure, and constructs and trains the LSTM neural network intraocular pressure recognition model for intraocular pressure recognition, thereby achieving dynamic intraocular pressure measurement and improving measurement accuracy.

The invention relates to the technical field of vision change prediction, in particular to a vision change prediction method based on a random forest algorithm. The method comprises the following steps: S1, collecting basic data related to vision change; s2, identifying features having significant influence on vision change by using a vision correlation method; s3, using a random forest as a prediction model, and training the prediction model through a retraining mechanism; and S4, performing vision change prediction on the new data by using the trained prediction model. According to the technology, through detailed data preprocessing steps including missing value removal or filling, abnormal value processing, data standardization or normalization and feature selection, the data quality and effectiveness of an input model are ensured, in addition, the vision correlation coefficient is optimized, and the accuracy of the vision correlation coefficient is improved. Particularly, the nonlinear relation and interaction among age, intraocular pressure and diopter are considered, so that the model can more accurately capture key influence factors of vision change.

The present application relates to vitrectomy technical field, specifically disclose a kind of accurate oil exchange method and its control system in minimally invasive vitrectomy, to the problems of mutual interference, intraocular pressure fluctuation, artificial push and team cooperation caused by the same channel shared by silicon oil injection and perfluorocarbon liquid suction in prior art, the present application is physically connected by three-way component silicon oil catheter and the silicon oil perfusion control interface of vitrectomy equipment, using gas-liquid exchange air pump to provide continuous stable air pressure power source, to drive silicon oil injection with constant working pressure;At the same time, by the single manual control of surgeon suction path, according to visual observation real-time adjustment suction speed, realize the independent double-channel control and dynamic balance of silicon oil injection and perfluorocarbon liquid suction.The present application is based on the high viscosity of silicon oil and the stable voltage characteristics of air pressure power source, significantly improves the accuracy, stability and safety of operation, reduces the operation difficulty and team cooperation dependence.

This invention proposes a flexible air-blowing device for measuring intraocular pressure (IOP), comprising an ocular surface IOP measurement optical system and a pulsed airflow jet system. The light emitted from the fixation lamp of the ocular surface IOP measurement optical system passes sequentially through a fixation beam splitter and a first semi-transparent mirror before reaching the ocular surface. The imaging light from the ocular surface passes sequentially through a first semi-transparent mirror, a second semi-transparent mirror, and an ocular surface imaging lens group before reaching an ocular surface imaging CCD. The pulsed airflow jet system is positioned along the optical path from the first semi-transparent mirror to the ocular surface and includes a rigid metal gas storage chamber. Inside the rigid metal gas storage chamber is a flexible pressure-stabilizing gas chamber. The inlet of the flexible pressure-stabilizing gas chamber is connected to a constant pressure replenishment valve, and the outlet is connected to a rigid jet nozzle. The rigid jet nozzle extends out of the rigid metal gas storage chamber and is aligned with the ocular surface, with its axis coaxial with the optical path from the first semi-transparent mirror to the ocular surface. This invention optimizes the output characteristics of the pulsed airflow, comprehensively improving the accuracy and stability of IOP measurement.

The application discloses a flexible ultrasonic patch for monitoring corneal elastic modulus and a preparation method thereof, the patch comprises, from top to bottom, a top flexible packaging layer, a top electrode layer, a piezoelectric layer, a bottom electrode layer, a bottom flexible base material isolation layer and a bottom flexible packaging layer; the piezoelectric layer is internally provided with an air column. Compared with a traditional medical hard probe for measuring corneal mechanical properties, the application has good flexibility, and the tensile property and bending resistance are greatly improved; the patch can be dynamically attached to the surface of an eyelid, and long-time corneal health monitoring of a human body can be realized; meanwhile, a non-invasive monitoring mode widens the application scene of the device, and real-time monitoring of corneal elastic modulus during a sleep process at night can be realized, and other eye features such as intraocular pressure can be further obtained.

The invention discloses an intelligent color-changing contact lens diagnosis system capable of synchronously monitoring intraocular pressure and body temperature, and is applied to the technical field of eye health monitoring. Comprising a composite substrate based on PDMS and pHEMA, an intraocular pressure sensor and a body temperature sensor which are jointly integrated in the composite substrate, a photochromic material and a thermochromic material which are contained in the composite substrate, and a periodic micro-column array which is constructed on the surface of the lens and is used for diagnosing intraocular pressure and body temperature abnormity based on a structural color visualization principle. Real-time synchronous high-precision non-invasive monitoring of intraocular pressure and body temperature is achieved, visual and visual diagnosis is achieved by means of structural color change of the periodic micro-column array, the composite substrate has good biocompatibility and long-term stability, and a non-invasive, real-time and convenient solution is provided for early diagnosis of eye diseases.

The invention discloses a noninvasive ICP detection and regulation system which comprises a transcranial Doppler monitoring module, an intraocular pressure sensing module, a tympanic membrane pressure monitoring module, an abdominal pressurization regulation module, a data fusion processing module, an alarm module and a power management module. The monitoring modules collect intracranial artery blood flow velocity waveforms, intraocular pressure pulsation and external auditory canal pressure fluctuation signals respectively and transmit the signals to the data fusion processing module for comprehensive analysis to generate an ICP evaluation result. When the evaluation value exceeds the preset range, the alarm module is triggered, and an instruction is sent to the abdomen pressurization regulation and control module to regulate the abdomen pressure. And the power management module supplies power to each module. According to the system, the detection accuracy is improved through multi-signal fusion, a monitoring-regulation closed-loop mechanism is formed, manual operation is not needed, the response time is shortened, and the regulation consistency is ensured.

Embodiments of the present disclosure provide a surgical instrument having a pressure sensor coupled to or adjacent to a distal end of the surgical instrument to achieve a direct intraocular pressure (IOP) reading of an eye. The surgical instrument may include a handheld device that is inserted into the eye to perform a surgical task.

A portable, non-invasive eye pressure monitoring device (120) comprising: a battery (106); a microscope (100) that positions the patient's eye to obtain clear scleral images for measuring eye pressure by means of sequential operations; at least one LED light (101) providing uniform illumination for taking scleral images, the intensity of which can be adjusted to avoid glare or shadows caused by uneven illumination; an objective lens (102) that focuses on the sclera by highlighting the blood vessel to ensure a sharp image; an image sensor (103) which receives the light and the magnified image of the objective lens and converts it into a digital format; a processing unit (104) which controls the processes from image acquisition to eye pressure estimation, comprising a pre-processing module (104b), a detection module (104c) and a pressure estimation module (104d), wherein the processing unit (104) finally displays the intraocular pressure to the user based on the vascular pattern via the display device.

The invention discloses an intraocular pressure change-based contact lens pressure developing system for sports eye protection, and relates to the technical field of medical instruments, a data collection unit and a sending unit are arranged in a contact lens, the data collection unit collects eye related parameters, and the eye related parameters are sent to a central control unit through the sending unit; the central control unit transmits the eye related parameters to the intraocular pressure processing unit, intraocular pressure prediction is carried out based on a preset intraocular pressure prediction model, and an intraocular pressure prediction value is obtained; the central control unit receives the intraocular pressure predicted value and outputs a corresponding color development signal based on a preset range threshold value, and the color development unit performs related color development based on the color development signal. The intraocular pressure detection system provided by the invention is intelligent, high in accuracy and high in reliability.

Described herein are devices, systems, and methods for monitoring intraocular pressure (IOP). A user can wear a microfluidic sensor contact lens. An imaging system can include a smartphone camera attachment designed for capturing images of the contact lens. An analysis software can convert the sensor readings from the captured images to a pattern display for users and medical practitioners to view.

The invention provides a scleroscope device for noninvasive monitoring of an aqueous humor outflow coefficient, a monitoring method and a system, relates to the technical field of medical monitoring equipment for the ophthalmology department, and solves the problems that an aqueous humor outflow coefficient measuring method in the prior art is high in invasiveness, incapable of achieving continuous monitoring, insufficient in precision and poor in data synchronism. The sclera lens device comprises a sclera lens, the sclera lens comprises a central area, an edge landing area and a transition area connecting the central area and the edge landing area, and the edge landing area is used for making contact with the sclera of a user and providing support for the transition area and the central area; the phased array transducer matrix comprises a plurality of transducers which are annularly distributed in the transition area; the dynamic deflection control module is arranged in the transition area and is electrically connected with each transducer so as to control the excitation time delay of each transducer; the intraocular pressure monitoring module is arranged in the central area; and the signal processing module is arranged in the transition area.

The invention discloses a non-invasive intraocular pressure monitoring device, and relates to the technical field of ophthalmology. The multifunctional probe is fixed to the inner side of the lens body and located at the position, right facing the cornea of a user, of the lens body when the lens is worn, and an OCT unit, a sound wave excitation and sensing unit and an environment temperature sensing unit are integrated in the multifunctional probe; the dynamic deformation process of the cornea under sound wave excitation is captured in a high-precision mode through the OCT technology, acoustic feedback signals of the cornea are analyzed synchronously through the sound wave sensor, the biomechanical state of the cornea is jointly represented from the two dimensions of optical mechanics and acoustic impedance, measurement errors caused by individual cornea characteristic differences are remarkably reduced, and the measurement accuracy is improved. An environment temperature sensor is introduced for real-time compensation, the influence of environment temperature changes on cornea tissue elasticity and sound wave propagation speed is effectively eliminated, a monitoring module is integrated in the intelligent glasses, cornea curvature changes are continuously monitored through a multifunctional sensing probe, and continuous intraocular pressure monitoring in a daily scene is achieved.