16 results about "Sclera" patented technology

An ophthalmic instrument (10) for crosslinking of the sclera (5) of an eye (1) is presented. The ophthalmic instrument (10) comprises a periocular arm (11) which extends from a proximal end (12) to a distal end (13) and which comprises a bend (14) to reach along at least part of an outer contour of the eye (1) with an inside face (15) of the periocular arm (11). An opening (16) is arranged through the inside face (15) at or near the distal end (13) of the periocular arm (11). A light delivery device (17) is arranged in the opening (16) of the periocular arm (11) to deliver light for local crosslinking of the sclera (5) of an eye (1) positioned adjacent to the inside face (15) of the periocular arm (11).

A shunt operable to be implanted on an eye is provided. The shunt includes a vein fluidic channel operable to be in fluid communication with an interior of the eye and operable to receive aqueous fluid from the interior of the eye. A body is fluidly coupled with the vein fluidic channel. A valve is disposed within the body and is operable to regulate intraocular pressure in the eye by opening and closing based on pressure from the aqueous fluid. A plurality of outlets are in fluid communication with the body opposite the vein fluidic channel in relation to the valve. The outlets are operable to release the aqueous fluid to the sclera of the eye.

This invention discloses a dual-pathway nanoformulation targeting the sclera, its preparation method, and its applications. The nanoformulation uses ketithial-modified fluorinated polyethyleneimine (TK-F-PEI) as a carrier, with a core loaded with hypoxia-inducible factor-1α small interfering RNA (HIF-1α siRNA) and a surface-coupled chemokine CCL2 nucleic acid aptamer. After local ocular administration, this formulation can efficiently target scleral lesions in myopic eyes, neutralizing CCL2 through the aptamer to improve the scleral inflammatory microenvironment, while simultaneously releasing siRNA to silence HIF-1α to inhibit the intracellular hypoxia pathway, synergistically reversing pathological scleral remodeling and delaying axial elongation. This invention's formulation exhibits strong targeting, good safety, and significant efficacy, providing a novel combined targeted drug delivery strategy for the clinical treatment of myopia, especially high myopia.

The application discloses a complex eye automatic detection and analysis method based on image processing and belongs to the cross field of artificial intelligence and medical image processing. The method comprises the following steps: collecting a front face image, extracting an eye region image through an adaptive human eye detection network; acquiring a mascara, an iris mask and a sclera mask; judging whether it is a complex situation based on the mascara and the sclera mask; if it is a complex situation, fitting an upper eyelid curve, taking the mascara as a repair mask and adding a curve constraint, and obtaining a de-occlusion reconstructed eye image through an image reconstruction network; recognizing eye feature points and performing geometric measurement, and outputting eye feature data and a visual result. The application can effectively process complex eye shapes such as long-mascara occlusion and ptosis, and significantly improves detection accuracy and robustness.

The subject invention pertains to a novel angle-closure detection method for risk assessment of primary angle closure (PAC) or primary angle closure glaucoma (PACG) to inform treatment decisions. According to certain embodiments, a plurality of cross-sectional images of the anterior segment of an eye centered at the pupil with preferably even radial separations are obtained from optical coherence tomography imaging. After identifying the position of scleral spur from the cross-sectional image captured at each angle-location, the anterior chamber angles are analyzed. Each angle-location of the eye is classified as (i) closed angle, (ii) narrow angle, or (iii) open angle. The extents of narrow angles and closed angles among all angle-locations across the 360° radial space are computed. Based on the extents of narrow angles and closed angles, a regression model is applied to compute the risk of PAC / PACG development.

A method for recognizing a fake eyeball using lights at two wavelengths comprises the steps of: illuminating simultaneously an eye region including the iris and sclera of a user with a light at a first wavelength and a light at a second wavelength; acquiring, synchronously with said illuminating, a single image of said eye region of said user, by using an imaging device in which R-color sensing elements, G-color sensing elements and B-color sensing elements are arranged in a Bayer pattern; setting an inspection area by specifying a scleral portion, in said single image; calculating a first color average detection amount by averaging the detection amounts of the first color sensing elements at a location corresponding to said inspection area in said single image and a second color average detection amount by averaging the detection amounts of the second color sensing elements at the location corresponding to said inspection area in said single image; and calculating a ratio between said first color average detection amount and said second color average detection amount, and comparing said ratio with a predetermined reference ratio to determine whether said user's eye is a fake eyeball.

This invention discloses a scleral image recognition and analysis method based on multimodal features, belonging to the field of medical image processing technology. The method includes acquiring five-view original eye images of the subject, and using a trained deep neural network to filter qualified images; locating key points such as the inner and outer canthi and performing size normalization and orientation correction; establishing a polar coordinate system with the pupil center as the origin, dividing the sclera into clock positions and aggregating them into four quadrants to achieve position segmentation; identifying microvessels through a target detection model, extracting morphological features and assigning position codes; matching the feature and code data to a structured scoring knowledge base, calculating the health score deduction value for each position, and finally generating a health assessment report containing a visual annotation map and quantitative scores. This method can accurately segment the scleral position, achieve the binding scoring of microvessel features and position codes, and improve the accuracy and standardization of scleral image analysis.

The present invention relates to a sterile ophthalmic composition comprising castor oil and medium-chain triglycerides; to the use of said composition in medicine, in particular for the treatment and / or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, lax eye lid syndrome, thyroid eye disease, pterygium, conjunctival laxity, epithelial damage caused by preservatives, epithelial or anterior chamber damage caused by ocular surgery, corneal limbal cell deficiency, corneal ulceration caused by physical or chemical agents, keratitis, sub-scleritis and uveitis.

This utility model relates to the field of medical surgical instruments, and discloses a scleral ligation band and a scleral ligation device. The scleral ligation band includes a main body, one end of which is provided with an elastic clip, and the other end of which is provided with multiple clip holes spaced apart along the extension direction of the main body. The elastic clip includes a connected limiting part and a locking part, with the limiting part located on the side of the locking part opposite to the main body. The cross-sectional width of the limiting part is greater than the cross-sectional width of the locking part. The locking part can pass through any clip hole and contact the corresponding clip hole wall. The limiting part can pass through the clip hole to the side of the main body opposite to the eyeball and contact the side wall of the main body opposite to the eyeball. This scleral ligation band and device eliminates the need for sutures and has adjustable pressure on the eyeball, significantly reducing the skill requirements for surgeons and the possibility of scleral perforation and bleeding, thus improving the safety and predictability of the surgery.

This utility model discloses a simulated eyeball for ophthalmic surgical demonstrations, comprising a spherical shell formed by splicing two hemispherical shells. The spherical shell includes a scleral simulated shell, an uveal simulated shell, and a retinal simulated shell. At designated locations inside the front end of the spherical shell are simulated structures for the iris, ciliary processes, lens, and suspensory ligaments. The circular hole in the center of the iris simulated structure serves as a simulated pupil. Through its unique three-layer shell design, from the outer scleral simulated shell to the inner uveal and retinal simulated shells, the simulated eyeball accurately reproduces the complex hierarchical structure of the human eye. In particular, the simulated structures within the eyeball, such as the iris, ciliary processes, lens, suspensory ligaments, and pupil, allow trainees to intuitively familiarize themselves with the key internal structures of the eyeball during demonstrations, providing accurate references for surgical procedures and significantly improving the demonstration effect.

An ocular needle guide for access into a space below a sclera of an eye comprises a housing. The housing has a contact surface and a needle guide surface. The contact surface defines a cavity within the housing. The contact surface extends at least partially along a contact plane. The needle guide surface extends about a needle axis to define a needle guide channel. The needle guide channel extends through the housing to an opening defined by the contact surface such that the needle guide channel opens to the cavity via the opening. The needle axis is substantially parallel to the contact plane. The contact surface is shaped such that when the ocular needle guide is positioned on the eye, a portion of the sclera is positioned within the cavity, and a surface of the eye contacts and takes a shape of the contact surface.

This utility model discloses an auxiliary measuring device for facial paralysis, comprising: a measuring panel, a forehead wrinkle vernier, and an sclera vernier. The measuring panel is a transparent thin plate and has a forehead wrinkle scale and an sclera scale. The forehead wrinkle vernier is adjustablely connected to the measuring panel along the extension direction of the forehead wrinkle scale. The sclera vernier is adjustablely connected to the measuring panel along the extension direction of the sclera scale. This auxiliary measuring device for facial paralysis accurately measures the forehead wrinkles when the patient raises their eyebrows by using the relative positions of the forehead wrinkle vernier and the forehead wrinkle scale; it also accurately measures the sclera exposure when the patient closes their eyes by using the relative positions of the sclera vernier and the sclera scale; it is convenient to use and easy to record data.

A high intraocular pressure discrimination method based on eye video dynamic fusion double-branch complementary features belongs to the technical field of physiological signal detection, and the method comprises the following steps: firstly, collecting eye videos and synchronously acquiring intraocular pressure labels to construct a training data set; secondly, using a trained semantic segmentation model to respectively segment the iris-pupil region and the sclera region from the eye video frames, and extracting the RGB time sequence signals of each region; thirdly, further extracting the blood volume pulse (BVP) signals from the two RGB signals respectively, segmenting by using a sliding window and converting into a two-dimensional space-time feature map; and finally, constructing and training a high intraocular pressure discrimination model DB-CFFNet, which respectively inputs the two space-time feature maps, realizes the classification and discrimination of the intraocular pressure state through double-branch feature extraction and fusion. The method realizes low-cost and continuous dynamic intraocular pressure state monitoring based on a common camera.

This invention relates to the field of biotechnology and discloses a method for screening drugs capable of preventing and / or treating posterior segment diseases of the eye. The method includes: first, decompressing the anterior chamber of an experimental animal; then, pre-establishing a "perforation-closure" channel in the sclera of the experimental animal; next, injecting the drug to be screened into the suprachoroidal space of the experimental animal through the "perforation-closure" channel in the sclera; and finally, evaluating the effectiveness of the drug in preventing and / or treating posterior segment diseases based on changes in the eye condition of the experimental animal. This invention reduces the incidence of ocular surface inflammation and improves safety by lowering intraocular pressure and creating a pre-closed scleral incision to prevent backflow of the injected AAV vector; it also provides a broader expression range and longer duration of action. Studies have shown that injecting shRNA targeting the TGF-β2 gene using the method of this invention inhibits myopia progression in a guinea pig model. The method provided by this invention is beneficial for screening gene therapy drugs related to posterior segment diseases.

This invention discloses a method for simultaneous detection of bilirubin and hemoglobin concentrations based on a single-frame image of the eye, comprising: acquiring an image containing a color chart and the eye under a standard light source; performing manual white balance and color correction matrix transformation based on the color chart; extracting the sclera and lower eyelid regions using a YOLOv8 segmentation network; inputting the left and right eye regions into a twin-Swin-Transformer network with shared weights; obtaining predicted values ​​through multi-scale feature fusion and a regression head; and introducing a feature consistency loss optimization model. This invention achieves high-precision simultaneous non-invasive detection of bilirubin and hemoglobin, with advantages such as good color constancy, strong anti-interference ability, and high clinical application value.

An eye depressor with a light for directing through a sclera. The depressor may removably accommodate a light instrument that might be used to illuminate an area in an eye during an eye surgery. The coupling of the light instrument to the depressor during the procedure may reduce the number of hands required in carrying out the surgery. This may be of particular benefit for eye surgery where limited surgical space is available.