4235 results about "Collagenan" patented technology

I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, "love handles" in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery system.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

The present disclosed subject matter relates to methods and compositions for restoring a diseased or damaged tooth such that infection is inhibited or eliminated and pulp regeneration is facilitated. The disclosed subject matter also includes a composition comprising a physiologically acceptable matrix seeded with pulp cells. The matrix can be capable of being injected into the pulp chamber of a tooth. In some embodiments, the matrix of a composition includes a hydrogel (e.g., collagen, chitosan, alginate, MATRIGEL™, gelatin, JELL-O®, fibrin), a mesh (e.g., polylactide-coglycolide (PLGA) mesh, polylactide (PLA) mesh, or polyglycolide (PGA) mesh, a cross-linked fiber mesh, a nanofiber mesh, a mesh fabric, biodegradable polymer mesh), a microsphere (biodegradable polymer microsphere, a hydrogel microsphere), or a combination of any of the foregoing. In yet other embodiments, the matrix includes a nanofiber, an artificial three-dimensional scaffold material, or a synthetic three-dimensional scaffold material.

Methods, systems, and devices to treat a region of skin; the treatment may be used to stimulate the production of collagen or destroy adipose tissue. The region of skin is exposed to a uniform energy application or series of applications. The region of skin may be exposed to positive and negative pressures. Therapeutic substances may be applied to the region of skin.

A wound dressing is provided comprising a wound treatment composition (1) including at least one absorbent or adsorbent compound contained within a sheath having an operatively inner and an operatively outer wall (5, and 6 respectively). The wound dressing is characterized in that the surface of the operatively inner wall that is to contact a wound in use is a substantially smooth continuous surface, conveniently of a plastic inner wall, selected for easy release from a wound. The inner wall is perforated (7) to enable exudate or slough to pass therethrough. The invention also provides a wound treatment composition characterized in that it comprises, in combination, an adsorbent material, preferably silica, for adsorbing moisture on or around a wound; and, a collagen, conveniently gelatin.

A treatment for subcutaneous fat and/or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.

The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided. The composition comprises a biodegradable acellular matrix, and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, integrated within the matrix. Also provided is an injectable composition comprising an acellular filler material (e.g., any type of collagen) and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, for correcting defects in skin, such as wrinkles or scars, and for augmenting tissue in the subject, particularly facial tissue.

By providing a hide processor or tanning drum with appropriate equipment for applying vacuum and microwave energy concurrently, these tanning machines become a versatile means of drying to yield dry hides that contain no salt yet store better than salted hides. In this novel process, fresh hides are loaded into the tanning machine where they are washed, demanured and then dried in situ under vacuum with concomitant application of microwave energy. Because the dried hides thus obtained are soft and pliable, they can be mechanically fleshed or shaved to remove the subcutaneous tissues rich in collagen and fat. Alternatively, the hides may be first dried in the tanning machine to below 35% moisture content and degreased using a solvent such as hexane. The solvent remaining in the hides after decantation of the unabsorbed liquid is vaporized at low temperature using vacuum and microwave energy. The hides are then dried in situ to the desired final moisture content. By shaving off the subcutaneous tissues of these hides a dry, fat-free, valuable undenatured collagen product is obtained. If the hides are unhaired before drying, they may be shaved and then accurately split. The process is also suitable for removing hair and fat from hide trimmings to obtain a valuable undenatured collagen product and fat. Furthermore, it can be used to remove fat from connective tissues and other animal offal containing no hair yielding a dry undenatured collagen product.

The invention discloses an extraction and preparation method for micromolecule fishskin collagen peptide, which comprises the following technical steps of: taking the fishskin of freshwater fish as raw material; removing non-collagenous protein; carrying out steps of degreasing, deodorizing, smashing and the like; under the acidic condition, carrying out heating hydrolysis processing to collagenous protein; controlling the degradation degree of the collagenous protein with an enzymolysis method; obtaining a target micromolecule collagen peptide with a membrane separation method; recycling protease, and then carrying out nanofiltration desalting; and after activated carbon binding resin is decolored and deodorized, carrying out spray drying to obtain the colorless and tasteless micromolecule fishskin collagen peptide. The extraction and preparation method disclosed by the invention has a simple technology, the protease is recycled by membrane separation, and therefore the cost is saved. The prepared micromolecule collagen peptide is colorless and tasteless and can be widely applied to industries relevant to the health of the human body, such as health care food, biomedicine, and cosmetics.

An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R¹ represents a carboxyl group or the like; R² represents a hydrogen atom or the like; R³ represents an optionally substituted aryl group or the like; X¹ represents a carbonyl group; X² represents a bonding hand; X³ represents a bonding hand; X⁴ represents a bonding hand or the like; and A represents an optionally substituted phenyl group or the like.)

The present invention is directed to devices for repair, replacement or augmentation of soft tissues in an organism. The devices comprise cellular compositions comprising cells and preferably, structural proteins such as collagen or elastin. The devices can also be used in methods for testing the effects of agents on soft tissues.

The invention provides a collagen facial mask and a preparation method thereof. The method comprises the following steps of: stirring 1 to 20 mass percent of aqueous solution of collagen and 0.1 to 2 mass percent of aqueous solution of a modifier at the temperature of between 20 and 60 DEG C for reacting for 15 to 45 minutes to obtain stock solution; adding a plasticizer, a functional additive and an antimicrobial growth promoter into the stock solution, and continuing to stir at the temperature of between 20 and 60 DEG C for 30 to 60 minutes to obtain mixed solution; and pouring the mixed solution into a die for forming, and drying at the temperature of between 30 and 60 DEG C for 3 to 10 hours to obtain the collagen facial mask. The prepared collagen facial mask is mainly formed by macromolecular substances extracted from natural animals and plants, safe and effective and does not have toxic or side effect, has the high heat stability, toughness, ductility and adhesion, and can be in fit with skin well and achieve the effects of preserving moisture doubly, softening cutin skin, resisting winkle, whitening the skin, restoring the skin and the like under the assistance of the functional additive; rejected materials of the facial mask are degradable, and do not cause environmental pollution; and the collagen facial mask can be widely applied in the field of daily cosmetics and has the excellent market application prospect.

Methods and devices for applying high intensity focused ultrasound to modulate collagen in animal tissue (such as to disrupt collagen fibrils in a mammal, such as a human), particularly to enhance the aesthetic appearance of skin, and/or to otherwise improve skin conditions.

A fiber reinforced basic collagen scaffold with neutralization capacity for delivery of protein based bioactives that have higher solubilities under acidic condition than at neutral pH.

The invention provides fish skin collagen based composite sponge and a preparation method thereof. The fish skin collagen based composite sponge is prepared by the steps of: based on fish skin collagen and chitosan as raw materials, freeze-drying, carrying out cross-linking, and carrying out secondary freeze drying. The composite sponge prepared by the invention can improve the disadvantages that the previous sponge is easy to degrade and the like, is simple in preparation process, is cheap and easy to obtain, and overcomes some defects of the existing collagen sponge. The fish skin collagen based composite sponge prepared by the invention has a specific three-screws structure of an I type collagen protein; a microstructure is a double-faced porous net-shaped sheet layer; and the fish skin collagen based composite sponge has good hygroscopicity, improves the degradability of the collagen sponge, is simple in preparation process and is cheap and easy to obtain, so that the fish skin collagen based composite sponge is a better biomedical material.

A moldable, bioresorbable, biocompatible, non-allergenic crosslinked collagen derivative dressing for the prevention of post extraction alveolar osteitis (dry socket) pain is disclosed along with methods for use of the gel. The dressing is placed at the time of surgery acting as a bone covering obtundant and physiologic scaffolding for the conduction of normal alveolar bone healing sequence of fibroblast ingrowth, blood vessel formation, and reossification of the extraction site defect. In one form, the dressing is a flowable, moldable, biocompatible, bioresorbable dressing prepared by reacting (i) a collagen derivative, such as gelatin or atelocollagen, and (ii) a non-cytotoxic crosslinking agent.

The invention relates to a CaP (Calcium Phosphate)/collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg/ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.

The invention discloses a method for preparing collagen oligopeptide. Animal skins are taken as raw materials, and are subjected to acid and surfactant pretreatment, enzymolysis, decoloration, membrane separation and drying to form the collagen oligopeptide. The relative molecular weight of the prepared collagen oligopeptide is mainly distributed below 1,000Dalton, and preferably, the Gaussian distribution peak area percentage of oligopeptide with the relative molecular weight of less than 1,000Dalton is over 85 percent and preferably over 90 percent. The method solves the general problems that the conventional collagen products have odor, are dark yellow and the like; and the obtained collagen oligopeptide powder is white, free of odor and good in mouthfeel, has high absorptivity and penetrability and can be widely applied to the cosmetics industry, the food industry and the like.

The present invention relates to a tissue defect repair implant including a porous material, wherein the material is expandable or compressible. The implant may be a scaffold, and may also be formed of a material such as, for example, collagen or demineralized bone matrix. Another aspect of the invention may be a method for the repair of a tissue defect in a patient in need thereof, including implanting an implant between two adjacent tissues, wherein the implant may include a porous material which is expandable or compressible. The two tissues may be soft tissue and hard tissue, and alternatively, the two tissues may be soft tissue, and may further be the same or different soft tissues.

The current invention involves a universal fishing bait fundamentally comprised of a matrix of fibrous collagen made up into any shape or design capable of attracting fish, that is 100% biodegradable and innocuous, that has physico-chemical properties that confer it with the capacity to accommodate liberate and diffuse attractant substances, and whose physico-mechanical properties confer it a soft and flexible texture, as well as making it resistant to breakage. Likewise, the invention outlines a procedure to prepare such a bait, and a precursor paste employed in the preparation, as well as the use of fibrous collagen in the preparation of said universal fishing bait.