8 results about "Collagen formation" patented technology

A polypeptide for repairing a skin wound or a mucosal injury, having obvious effects of alleviating the pathological development of acute and chronic gastrointestinal diseases, promoting repair of a skin wound or a mucosal injury, treating tumors, etc.; and use of the polypeptide in repairing a skin wound or a mucosal injury. By blocking or activating FGF / FGFR1 signaling, the polypeptide capable of binding to an FGFR1 receptor is capable of inhibiting or promoting cell proliferation, vascular hyperplasia, collagen formation, etc.

To provide an HSP47 gene expression enhancer that is effective in collagen formation and normalization of the collagen environment. [Solution] The present invention provides an HSP47 gene expression enhancer comprising a Beni Shizuka extract.

The aim is to prevent and / or improve skin conditions that negatively affect skin appearance, such as wrinkles and sagging, by promoting the formation of cyclic collagen. [Solution] Screening was conducted on the expression of proteoglycan-related genes involved in proteoglycan formation, and it was found that rosehip extract or safflower extract increases the gene expression of persican and periostin, which are proteoglycan-related genes. Thus, rosehip extract or safflower extract was identified as a promoter of cyclic collagen formation.

A kind of cell composition, including the cell cluster consisting of adipose-derived stem cells, endothelial cells and fibroblasts, as fat tissue regeneration unit.It is proved that the cell cluster composition of the application not only promotes the generation of fat, but also makes the generation of fat and angiogenesis and collagen formation etc.parallel, effectively promote the ability of fat tissue regeneration, while solving the problem of survival rate and insufficient vascularization after ADSCs transplantation.The combination of fat tissue regeneration unit and pGelMA not only solves the problem of vascularized fat tissue regeneration, but also promotes the formation of tissue similar to natural mammary tissue, providing a solution for realizing clinical breast reconstruction.

The invention belongs to the technical field of leather processing, and discloses a tanning agent-free short-process manufacturing method for antique-style leather. The method comprises the following steps: using bare hide or white wet leather as raw material, first dehydrating with anhydrous ethanol, and then treating with cashew nut shell liquid and nano zirconium dioxide; wherein, based on the weight of the bare hide or white wet leather, the moisture content in the bare hide or white wet leather after dehydration is 4-12 wt%; the addition amount of the cashew nut shell liquid is 2-12 wt%; and the addition amount of the nano zirconium dioxide is 0.2-1.5 wt%. In the present invention, the nano zirconium dioxide can catalyze the oxidation of unsaturated double bonds in the cashew nut shell liquid to form covalent bonds with amino groups of skin collagen, while the phenolic hydroxyl groups in the cashew nut shell liquid can form hydrogen bonds with the skin collagen. Under the synergistic effect of hydrogen bonding and covalent bonding, the cashew nut shell liquid is stably fixed on the skin collagen fibers, thereby improving the hydrophobic modification effect of the cashew nut shell liquid on the skin collagen fibers, and finally obtaining a soft, plump, natural cinnamon-colored, and rich nutty antique crust leather product.

The invention relates to the technical field of microneedle rollers, in particular to a microneedle roller capable of applying electric signals to the skin of a user and stimulating the skin. Comprises: a roller which is provided with a plurality of microneedles along the outer circumference and has a through-hole formed in the central axis; a signal generation unit that generates a plurality of signals and supplies the signals to the microneedles; a rotating shaft part provided in the through hole and including a conductor that transmits the plurality of signals generated by the signal generating part to the microneedle; and a handle, one end of which is rotatably connected with the rotating shaft part. The present invention provides a microneedle roller which promotes skin blood circulation of a user by applying an electric signal to a microneedle through a rotating shaft portion provided on a central shaft of the roller, thereby improving collagen formation in a corium layer.

The invention relates to a collagen-based artificial bone repair material and a preparation method thereof. The collagen-based artificial bone repair material comprises a compact layer formed by mixing mineralized collagen and a high-molecular polymer, the transition layer and the porous layer sequentially cover the compact layer, the pore sizes of the compact layer, the transition layer and the porous layer are sequentially increased, and the transition layer and the porous layer are both formed by mineralized collagen; the supporting slow-release layer is arranged between the compact layer and the transition layer or between the transition layer and the porous layer, and the supporting slow-release layer is a biodegradable polymer fiber net bearing a first growth factor; a second growth factor is loaded on the surface of the collagen-based artificial bone repair material. According to the technical scheme, gradient aperture design, a composite scaffold structure and at least two stages of growth factor slow release modes are introduced into a material system at the same time, the adaptability of the material in clinical complex bone defect repair can be effectively improved, and synergistic enhancement of biological activity and mechanical properties is achieved.

The invention discloses a preparation method of a self-polymerizable biomass-based fatty aldehyde tanning agent, which is characterized in that hydrogen peroxide is adopted to selectively oxidize biomass-based polyol at 60-90 DEG C to prepare the biomass-based fatty aldehyde tanning agent. The structure of the obtained aldehyde tanning agent contains hydroxyl and aldehyde group active groups, the aldehyde tanning agent and leather collagen can form stable covalent bonds, biomass-based fatty aldehyde tanning agents with different molecular sizes and reaction activities can be formed by controlling aldol condensation reaction between the tanning agents, effective regulation and control of permeation and combination of the biomass-based fatty aldehyde tanning agents in leather are achieved, and the tanning agent has the advantages of being simple in preparation process, low in cost and high in efficiency. Therefore, the damp-heat-resistant stability and the physical sensory performance of the leather are improved.