59 results about "Collagen formation" patented technology

A treatment for subcutaneous fat and / or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.

An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response. The method of the invention creates more normal dermal architectures in skin with limited depths of skin removal by the series of superficial treatments that may be comparable to the extent of neocollagenesis caused by a deep skin removal treatment (e.g., CO2 laser skin removal).

A treatment for subcutaneous fat and / or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.

A polarization based medical device (300) for optically stimulating the formation of collagen in tissue (100) comprises a light source (310) for providing a beam of light. A polarizer polarizes the beam of light. A first beam shaping optics (320) directs the polarized beam of light to a spatial light modulator (340). A second beam shaping optics (350) directs the polarized beam from the spatial light modulator to an area of interest within the tissue. A spatially controlled pattern of polarized light is directed onto the tissue, thereby affecting the orientation of formation of collagen within the tissue.

The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical damage on skin. Sufficient electric pulses applied to a region of skin surface temporarily create new pathways through the lipid skin barrier, thereby delivering an L-ascorbic acid-containing composition through the lipid skin barrier and enhancing production of collagen in the region of the skin so treated. A handheld electrical pulser apparatus, optionally table-top adaptable, and methods of use for cosmetic treatment of degenerative skin conditions are provided by the invention.

A method of stimulating collagen formation in a selected area of mammalian skin in which the selected area is irradiated with a source of visible or near infra-red radiation. The radiation is absorbable by intracellular chromophores to enhance cellular activity and increase collagen formation. A skin treatment device for carrying out the method of the invention is also described.

The invention provides a two-component whitening long-acting Shuiguang injection for correcting skin wrinkles. The injection comprises two components, i.e. a component 1 and a component 2, wherein thecomponent 1 is a gel made of a crosslinked hyaluronate and a non-crosslinked hyaluronate, and the component 2 is a diluent containing amino acid and whitening active components. The injection provided by the invention can supplement adequate nutrients to the skin, also can supplement collagen to form needed amino acids or polypeptides, and is added with whitening components, thus catering to theneeds of most beauty seekers for fair, watery and tender skin.

N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and / or their metal chelates. Use of N-substituted 3-hydroxy-4-pyridinones and their metal chelates as pharmaceutical agents for the treatment of diseases, such as parasitic and viral infections, conditions associated with inflammation and infection, and conditions mediated by cell-proliferation or collagen formation.

The invention discloses a 3D printed sodium alginate-collagen type I-ceramic composite scaffold and a preparation method and application thereof. The composite scaffold is mainly composed of sodium alginate, collagen type I and calcium magnesium silicate according to a mass ratio of (1-6): 2: (0-10) and utilizes calcium chloride as a crosslinking agent, wherein a mass fraction of calcium chloride in the composite scaffold is 1 to 10%. The preparation method comprises dispersing the calcium magnesium silicate powder in deionized water, fully mixing the solution, compounding the solution, collagen type I and sodium alginate to obtain uniform hydrogel, placing the hydrogel in a 3D printer, carrying out crosslinking with calcium chloride and printing a porous scaffold which is the composite scaffold. The composite scaffold can promote chondrocyte proliferation and ALP activity, has excellent biological activity and has an application value in tissue engineering.

The invention discloses a preparation method of a composite soft-tissue patch. Sustained-release microspheres containing human cell culture secretion are mixed with gel solution, then the mixture is compounded with an acellular dermal matrix under vacuum, and after drying and sterilization, the composite soft-tissue patch is obtained. The prepared composite patch can improve the biocompatibility and the bioactivity of the dermal matrix effectively. The experiment shows that compared with the single acellular dermal matrix, the patch can promote cell proliferation and collagen formation effectively and has better biocompatibility and better tissue remolding. The patch can be widely applied to closure of various wound surfaces, repair of various soft-tissue defects and reinforcement of weakplaces and can be prepared into micro particles to be used for filling various fine and weak or dented places by injection, thus having wider application prospect in clinic.

The present invention involves the isolation of plant based CNCs from the leaves of S. cumini. For the formation of NCs, a novel greener approach using S. cumini LE as reducing agent for in situ impregnation of AgNPs as fillers into CNCs as matrix is reported. The silver nitrate solution in three different concentrations of 1 mM, 5 mM and 10 mM was used to form NCs where AgNPs have been incorporated into CNCs matrix. The CNCs and NCs were characterized using SEM, TEM, XRD, Zeta potential, FT-IR, and UV-Vis spectroscopy. NCs developed in the form of film and ointment showed strong antimicrobial activity against both gram negative and gram positive bacteria. NCs wound dressing is capable of regulating wound exudates and providing moisture to wound responsible for faster healing of acute wounds. The observations from histopathological and biochemical assays confirmed that NCs enhance healing because of lesser inflammation, rapid angiogenesis, early collagen formation and enhanced rate of reepithelization.

The invention relates to the technical field of biological pharmacy, in particular to an anti-bacterial peptide, an anti-bacterial peptide hydrogel and a preparation method of the anti-bacterial peptide hydrogel. The amino acid sequence of the anti-bacterial peptide is shown as SEQ ID NO:1. Experiments show that the polypeptide of the anti-bacterial peptide has high antibacterial activity and excellent biocompatibility. The anti-bacterial peptide hydrogel is made of the anti-bacterial peptide, a photo-thermal reagent and a wound growth promoting factor. Tests show that the anti-bacterial peptide hydrogel has a good killing effect on bacteria, especially drug-resistant bacteria, on the surface of a biological film, a bacterial biofilm can be effectively spitted and removed, growth and proliferation of wound epidermal cells, collagen formation and angiogenesis are facilitated, and rapid healing of wounds infected by the bacterial biofilm is achieved.

The present invention relates to a collagen peptide-containing polycaprolactone microsphere filler and a preparation method therefor. Provided is a plastic surgery filler obtained by loading a collagen peptide into polycaprolactone microspheres, which, when injected into the body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects fora long period of time, thereby showing excellent properties of restoring or expanding the bulk of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

A polarization based medical device for optically stimulating the formation of collagen in tissue comprises a light source for providing a beam of light. A polarizer polarizes the beam of light. A first beam shaping optics directs the polarized beam of light to a spatial light modulator. A second beam shaping optics directs the polarized beam from the spatial light modulator to an area of interest within the tissue. A spatially controlled pattern of polarized light is directed onto the tissue, thereby affecting the orientation of formation of collagen within the tissue.

It has been discovered that vascular endothelial growth factor (“VEGF”) promotes migration of activated (but not differentiating) keratinocytes to skin. This growth factor specifically increases migration of keratinocytes of the “wounded skin” phenotype but does not have significant effects upon differentiated keratinocytes. It also increases collagen deposition and reduces wrinkles, enhances skin quality, and increases skin thickness to normal levels in individuals where skin has thinned due to age or disorder such as diabetes. It is particularly well suited for use as cosmeceuticals when applied in purified form and in known amounts. The data presented in the examples demonstrate efficacy and specificity of VEGF in enhancing migration of normal human keratinocytes as well as formation of new granulation tissue including collagen formation. VEGF induces keratinocyte and fibroblast migration, formation of new tissue, and not only induces deposition of collagen but improves alignment of the collagen fibers. Accordingly, this growth factor is highly suitable for use as a cosmeceutical, especially for skin resurfacing and reduction in wrinkles.

A polarization based medical device for optically stimulating the formation of collagen in tissue comprises a light source for providing a beam of light. A polarizer polarizes the beam of light. A first beam shaping optics directs the polarized beam of light to a spatial light modulator. A second beam shaping optics directs the polarized beam from the spatial light modulator to an area of interest within the tissue. A spatially controlled pattern of polarized light is directed onto the tissue, thereby affecting the orientation of formation of collagen within the tissue.

The invention provides a preparation method of nanofiber membrane. The method adopts polycaprolactone, gelatin and nagelschmidtite biological ceramic as raw materials, and uses a mixed electrospinningtechnique to prepare the composite nanofiber membrane used for wound healing. The composite nanofiber membrane can observably shorten the healing time of soft tissue chronic wounds, especially diabetes mellitus wounds, promote the angiogenesis, epidermis regeneration and collagen formation of wound areas, reduces inflammatory responses of chronic wounds, and has a good application prospect for soft tissue wound healing.

The present invention relates to a vitamin C-containing polycaprolactone microsphere, a filler comprising the same, and a preparation method therefor. Provided is a polycaprolactone microsphere fillerobtained by loading vitamin C into polycaprolactone microspheres, which, when injected into the body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent properties of restoring or expanding the bulk of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

The present disclosure relates to a polycaprolactone microsphere filler containing collagen peptide and a preparation method therefor. Provided is a polycaprolactone microsphere filler obtained by encapsulating collagen peptide in polycaprolactone microspheres, which, when injected into a living body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent restoration or volume expansion or wrinkle improvement properties of soft tissues such as cheeks, breasts, nose, lips, and buttocks.

The present invention provides an essence liquid and a mask liquid and a preparation method thereof, according to the method, biological macromolecules of a placenta can be powerfully hydrolyzed by strongly-polar small molecule group water, introduction of pollutants due to use of strong acid and alkali for hydrolysis in the prior art can be avoided, biological activity of placental small molecule matters can be retained in the finally-obtained placenta hydrolysis ultrafiltrate, free hormone components in the placenta are eliminated, the potential harm of the free hormone disrupting normal human endocrine function can be eliminated, and the skin-care essence liquid and the mask liquid and other skin-care production prepared from the placenta hydrolysis ultrafiltrate with the molecular weight of 1KD to 10KD have the effects of nourishing skin cells, promoting the growth and regeneration of the skin cells, promoting skin collagen formation and preventing skin melanin formation, do not contain any cortical hormone, may not hurt skin cells after long-term use, and have obvious effects of removing freckles, resisting wrinkle and tendering the skin.

The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and / or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders.

The invention provides an NK cell low-temperature preservation re-infusion liquid. According to the invention, a glucose and sodium chloride injection is added into the NK cell low-temperature preservation re-infusion liquid to serve as a diluent / buffer liquid, so that the effects of maintaining the pH value, the ion osmotic pressure and the colloid osmotic pressure and providing energy glucose for cells are achieved; the added human serum albumin can maintain the constant osmotic pressure of plasma colloid and supply nutrition; the added vitamin C can promote antibody and collagen formation and tissue repair, and meanwhile, the vitamin C also has the effects of resisting oxidation, resisting free radicals and inhibiting tyrosinase formation, so that the oxidative damage of cells can be reduced, and the accumulation of peroxides in the cells can be quickly relieved. According to the NK cell low-temperature preservation re-infusion liquid, the survival rate of NK cells can be kept at 80% or above after the NK cells are preserved for 48 h at the temperature of 4 DEG C, and a preparation can be directly re-infused.

The present disclosure relates to a polycaprolactone microsphere containing vitamin C, a filler including the same and a preparation method therefor. Provided is a polycaprolactone microsphere filler obtained by encapsulating vitamin C in polycaprolactone microspheres, which, when injected into a living body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent restoration or volume expansion or wrinkle improvement properties of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

A method and apparatus are disclosed for skin wrinkle removal. After applying a tube encircling a relatively small skin area along the wrinkled line, a set of laser beams will be activated. The laser beams are mounted around the tube, pointing to its center to create a mutual point of irradiation located just below the skin's wrinkle line. Optical energy from lasers is directed to a point under the skin by radiating through the transparent tube. For ease of use, the encircled skin portion is lifted, preferably by vacuum, enabling laser radiation to penetrate under the skin from outside the lifting tube. The apparatus is suitable for treating skin wrinkles by targeting the sub skin melanin without damaging skin surface. The apparatus may also be used for other aesthetic face treatments, including disorders located around the eye. The used laser radiation is in the wavelength region of 1500 to 1800 nm, which is regarded to be eye safe. Other laser wavelength could be used, especially in the 700 nm region with confidence, since most radiation is enclosed within the skin portion on the transparent tube. The treatment energy density level on the skin penetration point is relatively low and thus not harmful to the epidermis. However, heating effect is maximized at the central point just beneath the wrinkle—which causes damage to the collagen. Later on, when healing occurs, the skin will be stretched and wrinkles will be diminished. This technology is less damaging to the skin than that of the prior and targets only the under wrinkle collagen. Statistically, most of the recent clinical trials showed a histological evidence of new collagen formation and significant improvement in facial rhytides. Direct, under the skin irradiation, as in our art, will be less damaging to the skin epidermis yielding improved overall results.

The invention provides a bone health product, which comprises collagen, glucosamine, vitamin and zinc source. The provided bone health product organically combines the collagen, glucosamine, vitamin and zinc source together, thereby the absorption is easy; the production of proteoglycan and collagen in human body can be promoted for supplementing the joint synovial fluid, and the necessary material of cartilage tissue for recovering the health after the joint is injured can be provided, the collagen formation is promoted, calcareous absorption and production can be promoted, and the bone health product is helpful for health care effect to human bone.

An amino acid composition for collagen formation includes a first chain unit component, a second chain unit component, and a third chain unit component of collagen. The first chain unit component, the second chain unit component, and the third chain unit component are the same or different from each other, and each of the first chain unit component, the second chain unit component, and the third chain unit component is selected from the group consisting of al chain component, α2 chain component, α3 chain component, α4 chain component, α5 chain component, and α6 chain component. The amino acid composition includes Alanine, Phenylalanine, Cysteine, Aspartate, Asparagine, Glutamate, Glutamine, Glycine, Histidine, Leucine, Isoleucine, Lysine, Methionine, Proline, Arginine, Serine, Threonine, Valine, Tryptophan, and Tyrosine and / or the pharmaceutically acceptable salt or ester derivatives thereof.

It has been discovered that vascular endothelial growth factor (“VEGF”) promotes migration of activated (but not differentiating) keratinocytes to skin. This growth factor specifically increases migration of keratinocytes of the “wounded skin” phenotype but does not have significant effects upon differentiated keratinocytes. It also increases collagen deposition and reduces wrinkles, enhances skin quality, and increases skin thickness to normal levels in individuals where skin has thinned due to age or disorder such as diabetes. It is particularly well suited for use as cosmeceuticals when applied in purified form and in known amounts. The data presented in the examples demonstrate efficacy and specificity of VEGF in enhancing migration of normal human keratinocytes as well as formation of new granulation tissue including collagen formation. VEGF induces keratinocyte and fibroblast migration, formation of new tissue, and not only induces deposition of collagen but improves alignment of the collagen fibers. Accordingly, this growth factor is highly suitable for use as a cosmeceutical, especially for skin resurfacing and reduction in wrinkles.

The present invention is a new method and composition that enhance bone repair, formation, maintenance and slowing of bone resorption. The present invention relates to methods and compositions that enhance collagen formation, tendon health and tendon injury healing, bone maintenance and bone injury healing, and the prevention and treatment of metabolic diseases. The present invention is a part of the therapy to maintain bone health among patients with diabetic bone resorption and others with metabolic disorders. In one embodiment, the composition is a composite of hydroxyapatite and an organic matrix composed of milk pH-dependent serum proteins, i.e., bone morphogenic proteins (BMP), milk serum-derived specific proteins (MSSP), and milk serum derived proteins.

The invention discloses a photo-cured degradable composite guided bone regeneration membrane as well as a preparation method and application thereof. The guided bone regeneration membrane consists of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, wherein the collagen is fully soaked by the biodegradable polyester and then forms an interpenetrating network structure with the collagen, and the guided bone regeneration membrane has good shaping property before photo-curing and can adapt to the form of bone defects; after photo-curing, the degradable composite guided bone regeneration membrane has certain supporting performance and can maintain a space required by bone regeneration; meanwhile, the collagen membrane is wrapped by the biodegradable polyester, so that the degradation speed of the collagen is reduced, the action time of the guided bone regeneration membrane is prolonged, and sufficient time is provided for bone repair; and the addition of the magnesium powder or the zinc powder can promote the improvement of the biocompatibility of a material and improve the bone regeneration promoting capacity of the guided bone regeneration membrane. The guided bone regeneration membrane is a novel guided bone regeneration membrane which has supporting and barrier effects and can promote bone tissue regeneration.