12 results about "Collagen formation" patented technology

The invention belongs to the field of biological medicine, and discloses a preparation method and application of a mesenchymal stem cell-derived exosome entrapped valproic acid compound. According to the invention, the mesenchymal stem cell source exosome is used as a carrier, valproic acid is entrapped, and the compound of VPA entrapped by the exosome of MSCs is prepared by an ultrasonic method, so that the VPA-EXO prepared by the invention is proved to be capable of promoting faster repair of the wound surface by inhibiting inflammation, promoting collagen formation, accelerating angiogenesis and reepithelization of the wound surface. The valproic acid-loaded human umbilical cord mesenchymal stem cell exosome prepared by the invention is VPA-EXO prepared by an ultrasonic method, has no obvious toxicity to cells, and has obvious advantages.

A polypeptide for repairing a skin wound or a mucosal injury, having obvious effects of alleviating the pathological development of acute and chronic gastrointestinal diseases, promoting repair of a skin wound or a mucosal injury, treating tumors, etc.; and use of the polypeptide in repairing a skin wound or a mucosal injury. By blocking or activating FGF / FGFR1 signaling, the polypeptide capable of binding to an FGFR1 receptor is capable of inhibiting or promoting cell proliferation, vascular hyperplasia, collagen formation, etc.

To provide an HSP47 gene expression enhancer that is effective in collagen formation and normalization of the collagen environment. [Solution] The present invention provides an HSP47 gene expression enhancer comprising a Beni Shizuka extract.

A system for enhancing cartilage-specific collagen formation in a human body includes stem cells configured for injection into a region of the body, and a support garment configured for contact with the region of the body. The support garment includes a composite fabric having embedded semiconductor nanoparticles configured to release negative ions responsive to body heat generating a micro electromagnetic field in the region of the body. The support garment also includes embedded carbon nanoparticles configured to release infrared rays responsive to the body heat in the region of the body. A method for treating osteoarthritis in the human body includes: injecting the stem cells into the region of the body, and placing the support garment having the composite fabric in contact with the region of the body to form the micro electromagnetic field and generate the infrared rays in the region of the body.

The aim is to prevent and / or improve skin conditions that negatively affect skin appearance, such as wrinkles and sagging, by promoting the formation of cyclic collagen. [Solution] Screening was conducted on the expression of proteoglycan-related genes involved in proteoglycan formation, and it was found that rosehip extract or safflower extract increases the gene expression of persican and periostin, which are proteoglycan-related genes. Thus, rosehip extract or safflower extract was identified as a promoter of cyclic collagen formation.

A kind of cell composition, including the cell cluster consisting of adipose-derived stem cells, endothelial cells and fibroblasts, as fat tissue regeneration unit.It is proved that the cell cluster composition of the application not only promotes the generation of fat, but also makes the generation of fat and angiogenesis and collagen formation etc.parallel, effectively promote the ability of fat tissue regeneration, while solving the problem of survival rate and insufficient vascularization after ADSCs transplantation.The combination of fat tissue regeneration unit and pGelMA not only solves the problem of vascularized fat tissue regeneration, but also promotes the formation of tissue similar to natural mammary tissue, providing a solution for realizing clinical breast reconstruction.

The invention belongs to the technical field of leather processing, and discloses a tanning agent-free short-process manufacturing method for antique-style leather. The method comprises the following steps: using bare hide or white wet leather as raw material, first dehydrating with anhydrous ethanol, and then treating with cashew nut shell liquid and nano zirconium dioxide; wherein, based on the weight of the bare hide or white wet leather, the moisture content in the bare hide or white wet leather after dehydration is 4-12 wt%; the addition amount of the cashew nut shell liquid is 2-12 wt%; and the addition amount of the nano zirconium dioxide is 0.2-1.5 wt%. In the present invention, the nano zirconium dioxide can catalyze the oxidation of unsaturated double bonds in the cashew nut shell liquid to form covalent bonds with amino groups of skin collagen, while the phenolic hydroxyl groups in the cashew nut shell liquid can form hydrogen bonds with the skin collagen. Under the synergistic effect of hydrogen bonding and covalent bonding, the cashew nut shell liquid is stably fixed on the skin collagen fibers, thereby improving the hydrophobic modification effect of the cashew nut shell liquid on the skin collagen fibers, and finally obtaining a soft, plump, natural cinnamon-colored, and rich nutty antique crust leather product.

The invention relates to the technical field of microneedle rollers, in particular to a microneedle roller capable of applying electric signals to the skin of a user and stimulating the skin. Comprises: a roller which is provided with a plurality of microneedles along the outer circumference and has a through-hole formed in the central axis; a signal generation unit that generates a plurality of signals and supplies the signals to the microneedles; a rotating shaft part provided in the through hole and including a conductor that transmits the plurality of signals generated by the signal generating part to the microneedle; and a handle, one end of which is rotatably connected with the rotating shaft part. The present invention provides a microneedle roller which promotes skin blood circulation of a user by applying an electric signal to a microneedle through a rotating shaft portion provided on a central shaft of the roller, thereby improving collagen formation in a corium layer.

The present invention provides a surgical thread, comprising a modified cross-section fiber, wherein the modified cross-section fiber is in a twisted state. The surgical thread of the present invention has advantages of good coefficient of kinetic friction, good tensile strength, good elongation rate and good softness, and good safety, comprising no inflammatory potential, no cytotoxicity, no pyrogen, no acute systemic toxicity and no intradermal irritation potential, and has the efficacy of promotion of collagen formation, thereby being suitable for embedding in the face. The present invention further provides a cosmetic treatment and a manufacturing method for the surgical thread.

The invention relates to a collagen-based artificial bone repair material and a preparation method thereof. The collagen-based artificial bone repair material comprises a compact layer formed by mixing mineralized collagen and a high-molecular polymer, the transition layer and the porous layer sequentially cover the compact layer, the pore sizes of the compact layer, the transition layer and the porous layer are sequentially increased, and the transition layer and the porous layer are both formed by mineralized collagen; the supporting slow-release layer is arranged between the compact layer and the transition layer or between the transition layer and the porous layer, and the supporting slow-release layer is a biodegradable polymer fiber net bearing a first growth factor; a second growth factor is loaded on the surface of the collagen-based artificial bone repair material. According to the technical scheme, gradient aperture design, a composite scaffold structure and at least two stages of growth factor slow release modes are introduced into a material system at the same time, the adaptability of the material in clinical complex bone defect repair can be effectively improved, and synergistic enhancement of biological activity and mechanical properties is achieved.

The invention discloses a preparation method of a self-polymerizable biomass-based fatty aldehyde tanning agent, which is characterized in that hydrogen peroxide is adopted to selectively oxidize biomass-based polyol at 60-90 DEG C to prepare the biomass-based fatty aldehyde tanning agent. The structure of the obtained aldehyde tanning agent contains hydroxyl and aldehyde group active groups, the aldehyde tanning agent and leather collagen can form stable covalent bonds, biomass-based fatty aldehyde tanning agents with different molecular sizes and reaction activities can be formed by controlling aldol condensation reaction between the tanning agents, effective regulation and control of permeation and combination of the biomass-based fatty aldehyde tanning agents in leather are achieved, and the tanning agent has the advantages of being simple in preparation process, low in cost and high in efficiency. Therefore, the damp-heat-resistant stability and the physical sensory performance of the leather are improved.

The present invention relates to a method of preparing a culture broth of neural stem cells, having excellent abilities of reducing skin wrinkles or increasing skin elasticity, the culture broth comprising high concentrations of TIMP-1 and TIMP-2 capable of inhibiting the expression and activity of matrix metalloproteinases (MMPs) involved in collagen decomposition in the dermis. The culture broth of neural stem cells according to the present invention, which comprises, as active ingredients, high concentrations of TIMP-1 and TIMP-2 and low concentrations of various MMPs, restores the synthesis of collagen and elastin by suppressing the expression and activity of MMPs inhibiting collagen formation, and thus is useful as a composition for reducing skin wrinkles or increasing skin elasticity.