5 results about "Collagen formation" patented technology

To provide an HSP47 gene expression enhancer that is effective in collagen formation and normalization of the collagen environment. [Solution] The present invention provides an HSP47 gene expression enhancer comprising a Beni Shizuka extract.

The aim is to prevent and / or improve skin conditions that negatively affect skin appearance, such as wrinkles and sagging, by promoting the formation of cyclic collagen. [Solution] Screening was conducted on the expression of proteoglycan-related genes involved in proteoglycan formation, and it was found that rosehip extract or safflower extract increases the gene expression of persican and periostin, which are proteoglycan-related genes. Thus, rosehip extract or safflower extract was identified as a promoter of cyclic collagen formation.

A kind of cell composition, including the cell cluster consisting of adipose-derived stem cells, endothelial cells and fibroblasts, as fat tissue regeneration unit.It is proved that the cell cluster composition of the application not only promotes the generation of fat, but also makes the generation of fat and angiogenesis and collagen formation etc.parallel, effectively promote the ability of fat tissue regeneration, while solving the problem of survival rate and insufficient vascularization after ADSCs transplantation.The combination of fat tissue regeneration unit and pGelMA not only solves the problem of vascularized fat tissue regeneration, but also promotes the formation of tissue similar to natural mammary tissue, providing a solution for realizing clinical breast reconstruction.

The invention relates to a collagen-based artificial bone repair material and a preparation method thereof. The collagen-based artificial bone repair material comprises a compact layer formed by mixing mineralized collagen and a high-molecular polymer, the transition layer and the porous layer sequentially cover the compact layer, the pore sizes of the compact layer, the transition layer and the porous layer are sequentially increased, and the transition layer and the porous layer are both formed by mineralized collagen; the supporting slow-release layer is arranged between the compact layer and the transition layer or between the transition layer and the porous layer, and the supporting slow-release layer is a biodegradable polymer fiber net bearing a first growth factor; a second growth factor is loaded on the surface of the collagen-based artificial bone repair material. According to the technical scheme, gradient aperture design, a composite scaffold structure and at least two stages of growth factor slow release modes are introduced into a material system at the same time, the adaptability of the material in clinical complex bone defect repair can be effectively improved, and synergistic enhancement of biological activity and mechanical properties is achieved.

The invention discloses a preparation method of a self-polymerizable biomass-based fatty aldehyde tanning agent, which is characterized in that hydrogen peroxide is adopted to selectively oxidize biomass-based polyol at 60-90 DEG C to prepare the biomass-based fatty aldehyde tanning agent. The structure of the obtained aldehyde tanning agent contains hydroxyl and aldehyde group active groups, the aldehyde tanning agent and leather collagen can form stable covalent bonds, biomass-based fatty aldehyde tanning agents with different molecular sizes and reaction activities can be formed by controlling aldol condensation reaction between the tanning agents, effective regulation and control of permeation and combination of the biomass-based fatty aldehyde tanning agents in leather are achieved, and the tanning agent has the advantages of being simple in preparation process, low in cost and high in efficiency. Therefore, the damp-heat-resistant stability and the physical sensory performance of the leather are improved.