943 results about "Bone defect" patented technology

The invention provides a tumor type bone defect reconstruction method and system. The method comprises the following steps: acquiring bone defect information; constructing a bone defect restoration; constructing a bone defect three-dimensional model; and bone defect simulation surgery. According to the method, the bone defect information is obtained by evaluating the illness state of the patient, meanwhile, the anatomical structure of the bone tumor of the patient is subjected to structural evaluation through modern medical imaging, and the bone defect restoration is constructed in combination with the corresponding bone defect information; then, according to preset prosthesis design data, carrying out repair design on the bone defect prosthesis and obtaining three-dimensional skeleton data of a patient in real time, then, according to the obtained three-dimensional skeleton data, constructing a three-dimensional bone defect model and carrying out a bone defect simulation operation, and finally, predicting and optimizing the implantation position, direction and angle of the bone defect prosthesis. The effect of improving the construction accuracy of the bone defect prosthesis is achieved, and the problem that in the prior art, the construction accuracy of the bone defect prosthesis is low is solved.

The invention provides a shoulder joint replacement surgery navigation system and method, and relates to the technical field of computers, and the system comprises a controller and a navigation positioning device; the controller is in communication connection with the navigation positioning device; the controller comprises a preoperative planning module, a preoperative simulation module and an intra-operative execution module. According to the navigation system and method for the shoulder joint replacement surgery, by combining the preoperative medical image of the affected bone and the medical image of the healthy bone corresponding to the affected bone, the healthy form of the affected bone can be reflected more accurately under the condition that the affected bone has bone defect and / or abnormal form, and then prosthesis planning can be conducted based on the three-dimensional bone model of the affected bone, so that the patient experience is improved. The preoperative surgical planning is more objective and quantified, the movement range of the shoulder joint on the operative side of the patient after the prosthesis to be implanted is implanted into the affected bone can be simulated based on the parameter information of the prosthesis to be implanted, the accuracy and rationality of the prosthesis planning are further improved, and the accuracy and reliability of the orthopedic surgery are remarkably improved.

The invention provides an orthopedic surgery navigation method, device and system, electronic equipment and a storage medium, and relates to the technical field of computers.The method comprises the steps that a three-dimensional bone model of a diseased bone is generated based on a first image and a second image, and surgery parameters corresponding to the diseased bone are obtained based on the three-dimensional bone model and all bony mark points on the three-dimensional bone model, on the basis of the corresponding relation between all the bony mark points on the three-dimensional bone model and all the bony mark points on the affected bone, the affected bone and the three-dimensional bone model are registered, the mapping relation between the affected bone and the three-dimensional bone model and / or the first image is established, and surgical navigation is conducted on the basis of the surgical parameters corresponding to the affected bone and the mapping relation. According to the orthopedic surgery navigation method, device and system, the electronic equipment and the storage medium provided by the invention, more objective and quantitative preoperative surgery planning can be realized under the condition that the diseased bone of the patient has bone defect and / or abnormal shape, and more accurate diseased bone space positioning can be realized in the orthopedic surgery.

Hydrogel comprises hydroxyapatite nanowires and a base material for forming the hydrogel, and further comprises glucose oxidase (GOx), gallic acid, magnesium ions (Mg < 2 + >) and the like, the gallic acid and the Mg < 2 + > form Mg-MOF, and the GOx is loaded on the Mg-MOF, so that the diabetes microenvironment of a bone defect part is locally adjusted, and bone defect repair is facilitated. Through verification, the sustained-release gallic acid of GOx-MOF participates in cascade reaction, GOx is removed to generate H2O2, the benefit is maximized, and the sustained-release gallic acid has good effects of controlling blood glucose, removing ROS, regulating inflammation and promoting osteogenesis and angiogenesis. The research is expected to play a role in microenvironment regulation of diabetes mellitus bone regeneration and minimally invasive treatment of bone defects.

The invention relates to a bone organ constructed based on oxygen-releasing immune hydrogel microspheres and a preparation method and application thereof. An oxygen release material, macrophages and bone marrow mesenchymal stem cells are loaded in the oxygen release immune hydrogel microspheres. And adding the oxygen-releasing immune hydrogel microspheres into a culture medium for culturing to obtain the bone organ constructed based on the oxygen-releasing immune hydrogel microspheres. The oxygen release material (CaO2-HAp) is entrapped in the hydrogel microspheres, so that continuous oxygen supply can be provided in a defect area, the low-oxygen environment is improved, the activity of osteoblasts is improved, osteogenic differentiation is promoted, macrophages are entrapped by the microspheres, the immune microenvironment is regulated and controlled, the release of proinflammatory cytokines is reduced, the osteogenic efficiency is improved, and bone defect repair is accelerated. The micro-fluidic technology is utilized to accurately control the size and shape of the microspheres, so that the microspheres can adapt to irregular bone defects, bone organs are formed through long-term in-vitro culture, and the biological activity and adaptability of the bone repair material are improved.

The invention belongs to the field of biomedical materials, and particularly discloses a preparation method and application of a 3D printing porous composite scaffold. I-type collagen and silk fibroin composite gel is modified on a 3D printing three-element doped hydroxyapatite / polycaprolactone (PCL) composite scaffold with a polydopamine coating, the three-element doped hydroxyapatite is synthesized by using a chemical precipitation method, and Mg < 2 + >, Sr < 2 + > and SeO3 < 2-> ions are doped in crystal lattices. The 3D printing porous composite scaffold provided by the invention effectively simulates the structure and function of soft and hard combination of natural bones, is helpful for regulating and controlling the stem cell fate to improve the bone regeneration process, repairs bone defects while eliminating tumors, and can be applied to bone defect repair or osteosarcoma treatment.

The invention relates to the technical field of medical equipment, in particular to a preset tooth cutting method and system based on image data, and the method comprises the following steps: S1, obtaining multi-modal image data by using CT (Computed Tomography), MRI (Magnetic Resonance Imaging) and optical scanning technologies, and carrying out consistent analysis after preprocessing; and S2, performing automatic image segmentation by using a deep convolutional neural network (CNN). S3, optimizing the implant design through a generative adversarial network (GANs); s4, simulating and optimizing a cutting path through an augmented reality (AR) environment; and S5, laser micromachining is used for surface treatment of the implant. According to the method, the dentin cutting scheme matched with the specific shape and size of the bone defect area is designed through the data generated by scanning the three-dimensional shape of the complete tooth in advance, so that the image definition and the diagnosis accuracy are improved, the preoperative analysis is more accurate, and the subsequent personalized treatment design is effectively supported.

The invention discloses an in-situ injectable bone repair adhesive material with a double-sequence osteogenesis promoting function as well as a preparation method and application of the in-situ injectable bone repair adhesive material. The preparation method comprises the following steps: 1) sequentially carrying out dual chemical grafting modification on hyaluronic acid by using methacrylic anhydride and dopamine hydrochloride to obtain a DA-HAMA biomacromolecule with UV curing and adhesion functions; (2) preparing a Ca < 2 + > physical cross-linked sodium alginate microsphere material loaded with an osteogenesis promoting drug by using a micro-fluidic system; and (3) preparing a DA-HAMA solution under dark and heating conditions, adding the vascular promoting factors and the drug-loaded microspheres when the DA-HAMA solution is cooled to room temperature, uniformly mixing, and carrying out centrifugal defoaming and irradiation sterilization to obtain the in-situ injectable bone repair adhesive material. The bone repair adhesive material has the functions of being degradable, injectable, capable of being adhered in a wet state, promoting blood vessels and promoting bone formation, and a brand new strategy is provided for bone defect repair.

The invention discloses manganese and cerium co-doped modified sodium niobate, which is prepared from Nb2O5, MnO2, CeO2 and sodium hydroxide. The invention further discloses magnesium-based bone cement with the sonodynamic / nano-enzyme antibacterial function and the piezoelectric osteogenesis function. The magnesium-based bone cement is prepared from CaHPO4, NaH2PO4, MgO powder, hydroxyapatite and manganese-cerium co-doped modified sodium niobate. The magnesium-based bone cement with sonodynamic / nano-enzyme antibiosis and piezoelectric osteogenesis provided by the invention has piezoelectric enhanced sonodynamic and nano-enzyme synergistic antibacterial activity and piezoelectric osteogenesis activity, effectively removes bacteria / biological membranes, realizes combination of antibiosis and bone repair under different ultrasonic powers, effectively treats infectious bone defects, and has a good application prospect. The treatment effect of the MPC basal bone repair material is obviously improved.

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

A computer-implemented method of pre-operatively evaluating bone structure for use of a bone graft in a surgical procedure can comprise generating a three-dimensional bone model of a bone of a patient for output in a video display unit, determining a volume of interest (VOI) on the three-dimensional bone model where a bone defect exists, adding an internal bone property for bone matter of the bone structure to the three-dimensional bone model at the volume of interest, analyzing the internal bone property in the volume of interest relative to a treatment for a bone defect, and outputting indicia on the video display unit that indicates utility of a bone graft for the treatment. A surgical planning system can comprise memory having instructions for implementing the computer-implemented method.

The invention discloses a bone repair material based on pH controlled release and a preparation method thereof. The bone repair material comprises the following raw materials: polycaprolactone, nano hydroxyapatite and nano magnesium oxide. The composite bone repair scaffold has the beneficial effects that the composite bone repair scaffold with excellent biocompatibility, excellent osteogenesis performance, excellent degradation performance and pH controlled release of magnesium ions is prepared by printing the bone repair material through a 3D printing technology, a temporary three-dimensional structure can be provided for cells, cell adhesion, proliferation and differentiation are promoted, growth factors are released at the same time, and the growth rate of the cells is increased. The formation of new bone tissues is guided; the composite bone repair scaffold can continuously and quantitatively release magnesium ions through pH value control, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the magnesium ion release speed of the composite bone repair scaffold is increased, the anti-inflammatory effect is achieved, and the magnesium ions which are continuously released can promote bone tissue repair.

The invention belongs to the crossing field of biomedical engineering and additive manufacturing, and particularly relates to a 3D printing metamaterial piezoelectric bone defect repair scaffold, and the pore structure of the scaffold is formed by compounding three extremely small curved surface units, namely Gyandroid, SchwarzP and Diamond, which are defined by mathematical expressions; the porosity of the stent is 30%-70%, and the pore diameter range is 0.1-1 mm; the stent is made of a piezoelectric composite material composed of polyvinylidene fluoride (PVDF), polylactic acid and barium titanate, the piezoelectric composite material comprises the following components in percentage by mass: 30%-55% of polyvinylidene fluoride (PVDF), 20%-45% of polylactic acid (PLA) and 10%-25% of barium titanate (BaTiO3), and the sum of the mass percentages of all the components is 100%. Precise regulation and control of a macrostructure and a microstructure are achieved through a multi-material 3D printing technology, and the system has the mechanical adaptability, degradation controllability and the function of actively promoting bone regeneration and is suitable for large-section bone defect repair scenes such as craniomaxillofacial and long bones of four limbs.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention discloses a self-adaptive bionic cancellous bone defect prosthesis and a design method thereof, and belongs to the technical field of medical prostheses, the prosthesis is composed of biological interface gradient microporous structure parts and a main body bionic truss supporting structure part, the biological interface gradient microporous structure parts are arranged at the two ends of the main body bionic truss supporting structure part, and the main body bionic truss supporting structure part is arranged on the main body bionic truss supporting structure part. The method is mainly used for reconstructing bone defects, bionically designing a truss part of a main body with consistent arrangement direction and form of human body bone trabecula through an established linear relation between CT gray value and bone density-elasticity modulus, adaptively matching mechanical conduction of a bone structure, reducing stress shielding effect, and improving bone defect reconstruction efficiency. Meanwhile, various complex mechanical working condition requirements of the prosthesis are met, the prosthesis failure risk is reduced, and the service life of the prosthesis is prolonged.

The invention discloses a cationized silk fibroin / oxidized sodium hyaluronate injectable hydrogel as well as a preparation method and application thereof.The cationized silk fibroin / oxidized sodium hyaluronate injectable hydrogel is prepared by taking silk fibroin (SF) and sodium hyaluronate (SH) as main raw materials, performing cationization modification on the SF to obtain CSF, performing oxidation treatment on the SH to obtain OSH, and then adding the CSF and the OSH into the injectable hydrogel. The CSF / OSH injectable hydrogel with good adhesion, mechanical property, self-healing property, biocompatibility and antibacterial property can be formed through crosslinking by utilizing a Schiff base reaction between an amino group contained in the CSF and an aldehyde group contained in the OSH without adding any crosslinking agent. The CSF / OSH injectable hydrogel provided by the invention can play an important role in the treatment fields of wound healing, bone defects, cardiovascular diseases, brain diseases and the like, and has a wide application prospect in the fields of biomedicine and tissue engineering.

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.

The invention relates to a bone tumor repairing method based on three-dimensional reconstruction and a bionic structure. The method comprises the following steps: acquiring multi-modal medical image data of a bone tumor area of a patient to obtain an initial bone tumor three-dimensional model; generating a three-dimensional dynamic bone defect model for describing a bone tumor area based on the geometric structure of the initial bone tumor three-dimensional model; based on the three-dimensional dynamic bone defect model, generating a bionic implant three-dimensional model meeting bone defects; performing space alignment on the bionic implant three-dimensional model and the three-dimensional dynamic bone defect model to obtain a bone tumor repair model; carrying out restoration stability and osseointegration effect verification on the bone tumor restoration model to obtain a verification result; the verification result is used for indicating dynamic adjustment of the bionic implant three-dimensional model, and a final bone tumor repair three-dimensional model is obtained. By adopting the method, the accuracy, reliability and individuation level of bone tumor treatment can be improved.

An artificial bone repair material and a preparation method therefor, and a preparation method for a porous magnesium-containing tricalcium phosphate powder for the artificial bone repair material. The artificial bone repair material is a composite material having a porous structure, and the raw materials of the artificial bone repair material comprise collagen and a porous magnesium-containing tricalcium phosphate powder, wherein the porous magnesium-containing tricalcium phosphate powder is formed by subjecting a precipitate obtained after the reaction of a calcium salt solution, a magnesium salt solution and a phosphate solution to spray drying, and the particle size of the magnesium-containing tricalcium phosphate powder is 1-20 μm. The mass percentage of magnesium-containing tricalcium phosphate in the artificial bone repair material is 50-95%. The artificial bone repair material has a relatively high ceramic component content, and the binding property and dispersity of the ceramic component in collagen are relatively good, such that the artificial bone repair material has relatively high biological activity and degradability, and the new bone tissue can grow inside until a bone defect part is completely replaced, while the artificial bone repair material is degraded in vivo.

The invention discloses a 3D printing self-adaptive control system for bone defect, and relates to the technical field of 3D printing self-adaptive control, a miniaturized optical coherence tomography, a high-resolution camera, a force sense and temperature sensor and the like are installed on an operation site, and the whole process of material deposition and solidification is monitored; then, deviation is rapidly recognized through an anomaly detection and error prediction model, defect positions are output, and a closed-loop control unit is combined with model prediction control and self-adaptive path planning to achieve online adjustment of key variables such as the extrusion amount and the printing speed; when the defect cannot be made up automatically through parameter adjustment, the system can trigger local shutdown and secondary repair, the forming quality is evaluated through multi-modal scanning and a repair scoring function after repair, and the high matching degree and mechanical stability of the final bone scaffold and the bone defect part are ensured; the cooperation of multi-modal sensing and local path planning enables the system to have higher adaptability.

The invention relates to the technical field of bone tissue materials, and discloses a metal-doped biomimetic mineralized dECM cryogel and a preparation method and application thereof.The preparation method of the cryogel comprises the steps that firstly, hyaluronic acid and methacrylic anhydride are mixed in a solvent, the pH value is adjusted, a reaction is conducted, and methacrylic acid hyaluronic acid is obtained; then under the condition of a photoinitiator, mixing the methacrylic acid hyaluronic acid with an acellular extracellular matrix, and performing freezing and crosslinking treatment to obtain the cryogel, and finally, soaking the cryogel in a mineralization solution containing Ca < 2 + > and / or Mg < 2 + >, adding a buffer solution containing phosphite ions, incubating, and washing to obtain the crystal gel. The biomimetic mineralized dECM cryogel prepared by the method disclosed by the invention is good in ion release stability, can significantly improve the migration ability of HUVECs, contributes to promoting proliferation of rMSCs and improving the osteogenic differentiation potential of the rMSCs, and can be used for regeneration and repair of bone defects.

The invention discloses a preparation method of an antler-DCB (at) EVsABPCs bone graft material. The preparation method specifically comprises the following steps: step 1, preparing an Antler-DCB scaffold; step 2, preparing hydrogel containing 10% of HAMA and ABPCs-Evs (2, 2 '-(1, 2, 4-trimethyl-1, 3, 4- Step 3, mixing; step 4, taking Antler-DCB, and immersing the Antler-DCB into the HAMA hydrogel containing the ABPCs-EVs; and step 5, exposing to 405nm ultraviolet light for 30 seconds to obtain the bone graft material. The invention further discloses the antler-DCB (at) EVsABPCs bone graft material. According to the antler-DCB-coated EVsABPCs bone graft material and the preparation method thereof disclosed by the invention, the strong capability of adjusting osteogenesis, angiogenesis, neurogenesis and immune response is obtained, so that a potential therapeutic intervention measure is provided for treating serious bone defects.

The invention belongs to the technical field of biomedical materials and tissue regeneration, and particularly discloses hydrogel with a self-enhanced piezoelectric effect as well as a preparation method and application of the hydrogel. The hydrogel is prepared by taking microphone (MXene), cellulose nanofiber (CNF), tyramine grafted carboxymethyl cellulose (T-CMC) and regenerated silk fibroin (RSF) as main materials through an enzyme crosslinking reaction of horse radish peroxidase (HRP) and hydrogen peroxide (H2O2). The hydrogel has excellent mechanical properties, biocompatibility and safety, and can realize self-enhancement in vivo and generate stable piezoelectric signals. The piezoelectric stimulation can promote proliferation, migration and differentiation of osteogenesis-related cells and regulate and control a bone tissue microenvironment, so that formation and repair of new bones in a bone defect area are remarkably accelerated. The hydrogel can be used as an injectable or moldable bone tissue repair material, and is suitable for bone fracture, bone defect and other bone tissue regeneration scenes.

The invention relates to an attachment (1), a method for manufacturing an attachment (1), and a method for selecting a suitable attachment (1) for at least partially covering a bone defect site, wherein the attachment (1), in order to at least partially cover a bone defect site, has an extension in a first direction x, in a direction y orthogonal thereto, and in a direction z orthogonal to x and y, and the attachment (1) and / or at least one stiffening element (3) attached to the attachment (1) consists at least in part of a material which exhibits a shape memory effect and / or such a strong restoring force that, after elastic deformation, it returns to its original state.

The invention discloses a construction method and application of an in-vitro callus-like organ, the survival rate of the organ is improved by improving freeze-formed bio-ink, and a stable directional channel structure is further prepared, so that the internal mass transfer problem of the callus-like organ is improved, and the material exchange efficiency is improved. The forming mode of the callus-like organ is simple and effective, the stent material is easy to prepare, and the callus-like organ has mature cross-linking and printing characteristics, is expected to be applied to drug screening research or bone defect repair, is clear in process and simple in composition, and has relatively high operability.

The invention relates to a preparation method and medical application of a porous tantalum material based on an extremely small curved surface structure. The porous tantalum material is particularly applied to medical implants such as an interbody fusion cage, an artificial vertebral body, a hip joint acetabular cup, a joint filling block and a dental implant. The material is pure tantalum or tantalum-containing alloy (such as tantalum-titanium, tantalum-niobium, tantalum-zirconium, tantalum-titanium-niobium-zirconium, and the tantalum content is greater than 1%), the material is constructed by adopting an additive manufacturing technology, the porosity is 30-90%, compared with a truss pore channel structure (such as a rhombic dodecahedron), no obvious stress concentration point exists, the strength, the modulus, the anti-fatigue performance and the like are remarkably improved, and the application prospect is wide. The method is particularly suitable for structural and functional reconstruction of large-area and load-bearing bone defects.

The invention relates to a composite bone repair material, a preparation method and application, the preparation method comprises the following steps: immersing silkworm cocoons in a soap salt solution for degumming, drying to prepare degummed silk, dissolving the degummed silk in a lithium bromide solution, dialyzing for desalting, and concentrating to obtain a regenerated silk protein solution; mixing the regenerated silk fibroin solution with a gelatin solution to obtain a gel solution; mechanically shaking the gel solution, so that the gel solution is uniformly mixed, uniformly distributed bubbles are formed in the gel solution, and a silk protein / gelatin gel block is obtained; soaking and cleaning the silk protein / gelatin gel block in an ammonium sulfate solution to obtain silk protein / gelatin cross-linked gel; and freeze-drying the fibroin / gelatin cross-linked gel to obtain the fibroin / gelatin composite material. The composite bone repair material has the advantages that the composite bone repair material has a bionic porous structure, has excellent mechanical properties and also has good biocompatibility and osteogenic activity. The material can be applied to filling and regeneration repair of skull defects of the orthopedics department, the oral cavity, the plastic surgery (maxillofacial) and the neurosurgery department, and has high industrial production and clinical application prospects.

The invention discloses an engineered macrophage and a pharmaceutical composition and application thereof, and CCM3 expression in the engineered macrophage is inhibited, so that the engineered macrophage is polarized towards the M2 direction or the engineered macrophage is an M2 type macrophage. Besides, the invention further develops a temperature-sensitive cell-loaded hydrogel preparation which can promote polarization of macrophages in the M2 direction by inhibiting expression of signal molecules CCM3 on adhesion spots, and the temperature-sensitive cell-loaded hydrogel preparation can promote bone defect immune osteogenesis through local injection.

The utility model provides a curettage tool for apical surgery, which comprises a handle, a neck part and a curettage head, the handle is connected with the curettage head through the neck part, the neck part is bent by 80-100 degrees, the curettage head is shovel-shaped, and one end of the curettage head far away from the neck part is provided with a tip. Through the shovel-shaped design of the digging spoon head, the digging spoon can extend into the position where tooth roots are difficult to scrape, and the problem that the included angle between the root tip lesion lingual side and the tooth surface is an acute angle and is difficult to scrape thoroughly is solved. By means of the specially designed angle, diseased tissues right behind and behind the tooth root can be scraped more effectively, residues of granulation tissues can be reduced, the healing speed of root apex bone defects is increased, and the operation efficiency is improved.

The invention discloses a piezoelectric nanomaterial and application thereof. A KNN-based nanomaterial is constructed on the surface of a 3D-printed BCP scaffold for treating drug-resistant bacterial biofilm infection: KNN is doped with Ag2O and CoO to construct a phase boundary KNN piezoelectric material to enhance the piezoelectric catalytic activity of KNN; the nano-platform is introduced to the surface of the 3D-printed BCP scaffold, the nano-material efficiently generates ROS under ultrasonic response, quickly destroys MRSA bacterial biofilm at an early stage, and the release of Ag ions synergistically resists bacteria; under the action of pressure, KNN-Ag2O-CoO self-polarization stimulates osteoblast proliferation and differentiation, and the release of Co ions promotes osteogenesis and angiogenesis, further enhancing the later bone repair ability of the material system, thereby realizing a dual synergistic system with both "antibacterial and osteogenesis integration", and solving the insufficient application of BCP scaffolds in infectious bone defects.