277 results about "Bone defect" patented technology

The invention provides a natural bone repair material and a preparation method thereof. The material is animal cancellous bone inorganic salt particles or animal cancellous bone inorganic salt bone slices; the invention also relates to a preparation method of the natural bone repair material. The preparation method sequentially comprises the following steps: selecting materials, crushing, cleaning, removing organic matters, efficiently cleaning and drying, calcining and sterilizing. According to the method, inorganic base heating extraction and low-temperature calcination are adopted, so that the method is non-toxic, harmless, safe, efficient, low in organic matter residue and small in damage to the structure of a natural bone material, and the structure and morphology of the natural bone are better reserved; the defects of long construction period, low efficiency, high cost and the like existing in high-temperature calcination and organic reagent removal are avoided. The size of the bone repair material can be controlled, and the obtained bone repair material has certain mechanical strength, is not easy to break after being filled, and can play a good supporting role; and the material also has the advantages of high specific surface area, high porosity, low crystallinity, good hydrophilic performance, good biocompatibility and the like, and is suitable for bone defect repair.

The invention relates to the technical field of biological ceramic materials, in particular to a zirconium oxide bone repair scaffold material with a porous interconnection structure and a preparation method of the zirconium oxide bone repair scaffold material. The invention aims to solve the problems of poor mechanical property and fragile interconnection structure of the existing stent under high porosity. The core preparation process comprises the following steps of: performing acetone steam annealing and pre-fusion on a double-particle-size microsphere template to form a stable interconnection window prototype; then, a continuous hole wall main body is constructed through vacuum impregnation of high-viscosity zirconium oxide slurry, and then secondary positioning reinforcement is conducted on the interconnected neck parts through low-viscosity nano zirconium oxide sol; finally, diluted bioactive glass sol is introduced to endow the surface with biological activity, and a final product is obtained through temperature-controlled degreasing and sintering. According to the method, the pore connectivity, the mechanical strength and the biological activity of the scaffold are synergistically optimized through template pre-fusion and partition sequential processes, and the method is suitable for repairing load-bearing bone defects.

The invention discloses a bone defect repair material suitability prediction method based on deep learning, and the method comprises the steps: carrying out the overlapping and uniform partitioning of a bone defect region and a host bone region in three-dimensional CT image data, carrying out the position coding and feature extraction of a plurality of sub-blocks through a three-dimensional visual Transform model of multi-scale position coding, and obtaining the anatomical and functional features; calculating a bone metabolism activity score and a systemic inflammation score based on blood detection data, and then constructing pathophysiological features; performing multi-round interaction on the anatomical and functional features, the pathophysiological features, the parameter data and the multidirectional multi-head cross attention layer, in each round, selecting one modal feature as a query vector, and selecting any modal feature in the rest modal features as a key vector and a value vector; and fusing the interaction features of each round, and determining the suitability score and the risk level of the bone repair material by combining the attention weight and the bone metabolism activity score in the multidirectional multi-head cross attention layer.

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The invention discloses a preparation method of a micron-sized cell-matrix co-polymer biological material. The preparation method comprises the following steps: firstly, inducing SHED cells in an ultra-low adsorption plate by using an alpha-MEM culture medium containing serum, GlutaMAXI, vitamin C and the like to form micron-sized spheres (SHED spheres); secondly, taking human dentin, and carrying out mechanical crushing, EDTA (Ethylene Diamine Tetraacetic Acid) demineralization, grinding and sterilization to prepare 1-100 microns of dentin matrix particles (DDMPs); and finally, by taking the GelMA hydrogel as a carrier, entrapping SHED spphere and DDMPs, and carrying out 405nm photo-crosslinking for 30 seconds to form the hydrogel. The co-polymer can significantly promote angiogenesis and osteogenesis coupling regeneration in a bone defect model, and is suitable for oral cavity and cranio-maxillofacial bone repair.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention discloses a body temperature responsive wet adhesive as well as a preparation method and application thereof in bone defect repair, and belongs to the technical field of preparation of bone defect repair materials. Carbon-carbon double bonds in methoxyethyl acrylate (MEA), N-isopropylacrylamide (NIP) and acrylic acid (AA) are subjected to a free radical polymerization reaction to generate a polymer chain, and a cross-linking agent containing metal cations is added for cross-linking. The body temperature responsive wet adhesive has a good wet adhesion effect and the ability of improving the stability of bone meal, and can solve the technical problem of bone substitute displacement caused by unstable fixation of a barrier membrane.

The utility model belongs to the technical field of composite bone defect repair materials, and particularly relates to an osteogenic activity nHA / SF composite bone defect repair material compression resistance detection device which comprises a detection frame, and the bottom end of the inner side of the detection frame is fixedly connected with a detection base; a stretching assembly; the pressure sensor is arranged at a position on one side of the pressure detection seat; the stretching assembly is used in cooperation with the detection base and the detection pressure base. A positioning assembly; the detection assembly is arranged at one end of the detection pressure seat and corresponds to the stretching assembly; through the structural matching design of the detection base, the detection pressure base and the stretching assembly, after the bottom end of the bone repair material is fixed to the detection base, the stretching assembly is adjusted to the position below the detection pressure base, and then the stretching assembly is fixed to the top end of the bone repair material; and the detection pressure seat is moved upwards, so that the detection of the stretchability of the bone repair material is facilitated, and the detection diversity of the device is improved.

The invention belongs to the technical field of biomedical materials, and relates to an ultrasonic-induced inorganic afterglow luminescent material for promoting tissue and organ defect repair and a preparation method and application thereof, the preparation method comprises the following steps: S1, dispersing an afterglow luminescent material and citric acid in an aqueous solution to obtain a hydrothermal reaction precursor solution; s2, adding a titanium oxide-based material into the precursor solution provided in S1, and carrying out a hydrothermal reaction in a reaction kettle to obtain a titanium oxide-based luminescent material loaded with an afterglow material; wherein the afterglow material is one or more of an aluminate-based afterglow luminescent material and a titanate afterglow luminescent material. Compared with the prior art, the prepared ultrasonic-induced inorganic afterglow luminescent material is formed by compounding titanium oxide and an afterglow material, and afterglow luminescence can be generated under ultrasonic excitation. Microalgae with photosynthesis are loaded, oxygen is supplied to the hypoxic bone defect part through ultrasonic regulation and control, revascularization is promoted, and efficient repair of bone defects is achieved.

This invention discloses a method for preparing and applying a shell-core composite flexible biomaterial. The flexible biomaterial consists of an outer PMMA electrospun layer, a middle PTFF or PE layer, and a core PEG hydrogel; both the PMMA electrospun layer and the middle layer are porous. This flexible material is soft and elastic, exhibiting good film-forming and osteogenic induction effects. Animal experiments have confirmed that, compared to traditional bone cement, the flexible composite bone cement-induced biofilm shows an increase in CD31-positive cells (representing angiogenesis) and M2 macrophages (representing tissue repair), exhibiting better film-forming properties. It is a promising composite biomaterial that can be widely applied in the treatment of soft tissue defects, bone defects, and bone infections, achieving better therapeutic effects.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

Methods are provided for aesthetic restoration and reconstruction of bone loss, deficit, defect, or a combination thereof. The methods include administration of one or more suitable bone derived compositions by a minimally invasive procedure such as injection using a needle, syringe, etc., placement in or through a small incision, or a combination thereof. The properties and characteristics of the bone derived composition, including without limitation, flowability, injectability, size, shape, and physical form, are limited only by the requirement that they are capable of administration by a minimally invasive technique. For example, these methods are effective for restoration of facial features, e.g., lost chin definition, jawline definition, bone around nasal lines, and bone around the upper and lower eye area. These methods are also effective for treatment of bone deficiency and loss in other body features such as shoulders and collarbones, pelvis, feet, ankles, hands, and wrists.

The invention discloses a polysaccharide-tea polyphenol-metal compound, which is formed by dispersing a metal-tea polyphenol nano ligand in polysaccharide gel formed by covalent crosslinking of atractylodes macrocephala polysaccharide and sodium alginate, and the metal-polyphenol nano ligand is a nano complex formed by coordination of tea polyphenol and metal ions. The invention also discloses a preparation method and application thereof. The rhizoma atractylodis macrocephalae polysaccharide-sodium alginate-tea polyphenol derivative-metal composite system disclosed by the invention not only can improve the stability and release behavior of tea polyphenol in vivo, but also can regulate and control an immunometabolism microenvironment in a bone repair process, induce inflammation resolution and promote angiogenesis and bone matrix deposition, so that the bone repair effect is improved. Multiple synergistic effects of inflammation resistance, oxidation resistance, vascularization promotion and osteogenesis induction are realized, so that repair and regeneration of skull defects are remarkably accelerated, and a new intelligent immunometabolism regulation strategy is provided for repair of complex bone defects.

The present disclosure relates to a composite material for application to a bone defect site to promote new bone growth at the site comprising: a combination of freeze-dried mineralized bone allograft particles; and a monophasic gel comprising cross-linked hyaluronic acid; wherein the hyaluronic acid is cross-linked by a cross-linking agent, the cross-linking agent being a diglycidyl ether. The present disclosure also relates to a method to obtain a composite material for application to a bone defect site to promote new bone growth at the site comprising mixing freeze-dried mineralized bone allograft particles with a monophasic gel comprising hyaluronic acid; and to a bone regenerative material comprising the composite material as defined herein for use in a method of treating a patient suffering from a degenerative bone condition, bone loss, bone deficiency or bone atrophy.

The application belongs to the technical field of biomedical materials, and relates to an ultrasonic-induced inorganic afterglow luminescent material for promoting repair of tissue and organ defects as well as a preparation method and application thereof, and comprises the following steps: S1, dispersing an afterglow luminescent material and citric acid in an aqueous solution to obtain a precursor solution for hydrothermal reaction; and S2, adding a titanium oxide-based material to the precursor solution provided in S1 to perform hydrothermal reaction in a reaction kettle to obtain a titanium oxide-based luminescent material loaded with the afterglow material; wherein the afterglow material is one or more of an aluminate-based afterglow luminescent material and a titanate afterglow luminescent material. Compared with the prior art, the ultrasonic-induced inorganic afterglow luminescent material prepared in the application is composed of titanium oxide and the afterglow material, and can produce afterglow luminescence under ultrasonic excitation. By loading microalgae with photosynthesis, oxygen supply to an oxygen-deficient bone defect site is controlled by ultrasonic waves, blood vessel regeneration is promoted, and efficient repair of the bone defect is realized.

The invention discloses double-response hydrogel as well as a preparation method and application thereof. The double-response hydrogel comprises a three-dimensional porous network hydrogel matrix, and tea polyphenol and nano silicon nitride which are loaded in the hydrogel matrix, the three-dimensional porous network hydrogel matrix is prepared from o-nitrobenzene grafted hyaluronic acid and carboxyl phenylboronic acid modified methyl chitosan. According to the hydrogel disclosed by the invention, in a low-pH / high-ROS microenvironment of a diabetic periodontitis focus, boric acid ester bonds are broken, tea polyphenol is released, and the tea polyphenol plays an anti-inflammatory role by efficiently removing active oxygen and inhibiting inflammatory factors; meanwhile, the Schiff base bond is dissociated to release the nano silicon nitride, and the nano silicon nitride significantly promotes angiogenesis and osteogenic differentiation and accelerates bone defect repair by activating a redox signal, inducing cell autophagy, regulating metabolic reprogramming and other pathways.

The utility model relates to periodontal surgery technical field, especially a kind of periodontal surgery granulation tissue removal instrument set, including, placing tray, the placing tray is provided with the adaptation area that can place six appliances, the placing tray includes the square open-bottom portion with waist line type, and the limiting plate is set in its inner cavity two sides, the rotating handle is movably provided in the length direction both ends of placing tray;Six The appliance is bone defect granulation removal instrument and alveolar crypt granulation removal instrument respectively.The application scheme can effectively help doctor to realize the removal of granulation tissue in clinical process, reduce the influence of residual granulation tissue on periodontal tissue and bone regeneration, reduce the muscle fatigue of doctor, improve the debridement efficiency and regeneration success probability.

The application discloses a preparation method of a high-mechanical-matching-degree prosthesis based on topological optimization, which comprises the following steps: reconstructing a bone defect model by scanning CT data of a target region, and performing smoothing treatment on the model; constructing a prosthesis contour; determining a prosthesis porosity distribution through topological optimization, and obtaining regions with different density ranges of the prosthesis; replacing the regions with different density ranges in step 3 with random microporous structures with different pore diameters and porosities according to required biological properties and mechanical properties, so as to obtain a prosthesis model matched with a mechanical environment of a defect; and printing a prosthesis embryo, and performing a defatting and sintering process to obtain the prosthesis. The application realizes the best distribution of micropores in the prosthesis through topological optimization, and designs the random microporous structures with natural transition according to the topological optimization result, so that the stress distribution of the prosthesis is more uniform, and the mechanical and biological requirements of the prosthesis in bone repair are met.

The invention relates to the field of medical beauty industry, and particularly discloses intelligent response type hydroxyapatite medical beauty gel as well as a preparation method and application thereof. The intelligent response type hydroxyapatite medical beauty gel is prepared from the following raw material components: 90 to 95 parts of hydroxyapatite, 35 to 40 parts of regenerated silk fibroin composite magnetic microspheres, 50 to 55 parts of hyaluronic acid, 20 to 25 parts of recombinant III type humanized collagen and 15 to 20 parts of basic fibroblast growth factor sustained release microspheres. The preparation method comprises the following steps: uniformly dispersing all the components in hyaluronic acid, and stirring to obtain the medical beauty gel. The intelligent response type hydroxyapatite medical beauty gel belongs to an important gel material in orthopedic repair in the medical beauty industry, can well repair a bone defect part, and has excellent osteogenesis performance, biocompatibility and biological safety in vivo; and the product has the great advantages of high safety and good beautifying effect in medical beautifying bone shaping and bone repair.

The invention discloses a 3D printing method for an osteogenesis technology and a personalized box-type titanium plate, and relates to the field of manufacturing of medical instruments, and the 3D printing method specifically comprises the following steps: S1, obtaining and preprocessing three-dimensional data of a jaw bone of a patient; s2, three-dimensional reconstruction and virtual repair of an ideal contour before bone defect; s3, digitally designing the personalized box type titanium plate; s4, the personalized box type titanium plate is manufactured through 3D printing; and S5, clinical application in an operation. According to the 3D printing method for the osteogenesis technology and the personalized box-type titanium plate, the personalized box-type titanium plate can be passively placed in place in an operation, that is, the shape of the personalized box-type titanium plate is naturally matched with a bone defect area, and an ideal bone arch outline can be perfectly recovered after the personalized box-type titanium plate is placed. The dependence on the personal skill of doctors is reduced, the operation result has predictability and repeatability, and the fixing stability of the box-type titanium plate is far better than that of a bone block because the box-type titanium plate is directly fixed on the residual healthy basal bone through the screws.

The invention provides a preparation method and application of a BMP-2 / Apt19S two-factor immobilized mesoporous bioglass material, and belongs to the technical field of biomaterials. The mesoporous bioglass material with an ordered mesoporous structure, high specific surface area and good biological activity is stably prepared by combining a sol-gel method with a surfactant template technology; by introducing carboxyethyl silanetriol sodium, carboxyl functionalization on the surface of the material is realized, and further through amide reaction, a deoxynucleotide fragment Apt19S is grafted, so that the material has good stem cell collection capability and bone-induced growth factor BMP-2 loading capability; the method is simple in process, and the biological activity of the growth factor can be well maintained. The prepared BMP-2 / Apt19S two-factor immobilized mesoporous bioglass material is expected to realize targeted enrichment and slow release of drugs in the field of bone defect repair, improves bone regeneration efficiency, and has important clinical application prospects.

The invention relates to the technical field of oral implantation, in particular to a bone meal filling device for dental restoration. Comprising a double-layer barrel, the double-layer barrel is composed of an outer layer and an inner layer, a connecting barrel is connected to the side face of the double-layer barrel, a piston barrel is arranged on the inner layer of the double-layer barrel, a powder outlet is formed in the bottom of the piston barrel, a pressing mechanism is arranged in the piston barrel and used for pressing bone meal in the piston barrel into a tooth groove through the powder outlet, and a rubber ring is connected to the bottom of the double-layer barrel. The bottom of the rubber ring is connected with a barrel. By arranging a positioning and clamping structure composed of the limiting ring, the rotating ring and the elastic clamp, the device can be stably fixed to adjacent healthy teeth, the constant distance between the powder outlet and an alveolar bone defect area is automatically maintained, and errors and fatigue caused by manual distance control of an operator are avoided; meanwhile, the pressing powder supply operation can be completed by one hand, the other hand is liberated to be used for sucking saliva, pulling soft tissue or being matched with an assistant, and the operation smoothness and the overall efficiency are remarkably improved.

The invention belongs to the technical field of medical experimental animal models, and discloses a small animal model for skull base high-flow cerebrospinal fluid leakage and skull base reconstruction as well as a construction method and application of the small animal model. The technical obstacle that due to the fact that the nasal cavity of a small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the skull base through the nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for tissue healing after the endoscopic transnasal skull base surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow cerebrospinal fluid leakage of small animals, the standardized bone defect constructed in the middle skull base butterfly saddle area can cause continuous and high-flow cerebrospinal fluid leakage; autologous bone flap and free mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde intracranial infection research after an operation.

The application discloses a metformin-induced stem cell-derived extracellular matrix material and a preparation method and application thereof, and relates to the technical field of biological materials. The preparation method comprises the following steps: inoculating mesenchymal stem cells on a pretreated culture carrier, and using a culture system containing metformin to induce and treat the mesenchymal stem cells; adding ascorbic acid to induce and culture extracellular matrix secretion; carrying out decellularization treatment and nuclease treatment on the metformin-induced extracellular matrix; collecting the metformin-induced stem cell-derived extracellular matrix, mixing the metformin-induced stem cell-derived extracellular matrix with an aqueous medium, and enriching and forming an extracellular matrix precipitate through centrifugal treatment; and sequentially carrying out freezing treatment and thawing treatment on the extracellular matrix precipitate to obtain the metformin-induced stem cell-derived extracellular matrix material. The metformin is used to induce the mesenchymal stem cells to secrete an engineered extracellular matrix, and the engineered extracellular matrix is used to promote the repair of bone defects, skeletal muscle injuries and musculoskeletal joint defects in a diabetic environment.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

The invention discloses a bone targeting exosome polypeptide delivery system based on a biological orthogonal strategy and a preparation method and application thereof, and relates to the technical field of biological medicine and drug delivery. The bone targeting exosome polypeptide delivery system based on the biological orthogonal strategy comprises an engineered exosome as a carrier and an osteogenesis-promoting therapeutic polypeptide, wherein the osteogenesis-promoting therapeutic polypeptide is anchored on the membrane surface of the engineered exosome; a fusion protein is displayed on the membrane surface of the engineered exosome, and the fusion protein is formed by fusing a bone targeting ligand and an industrial exosome transmembrane scaffold protein; the osteogenesis-promoting therapeutic polypeptide is connected with the industrial exosome through the flexible spacer arm, and the membrane surface steric hindrance is reduced through the flexible spacer arm so as to improve the accessibility of the active fragment of the polypeptide; the delivery system provided by the invention can improve the targeted enrichment and treatment efficiency of osteogenesis promoting drugs in bone tissues, and is suitable for intervention of bone metabolism related diseases such as osteoporosis, delayed fracture healing, bone defects and the like.

The invention provides a composite growth factor composition capable of promoting proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, a method and application. The invention provides the composite growth factor composition by simulating a natural secretion mode of a decalcified bone matrix of the mandible of an SD (Sprague Dawley) rat on the seventh day, the composite growth factor composition comprises BMP-2 (400-600 pg / ml), TGF-beta1 (5-7 ng / ml) and IGF-1 (150-250 ng / ml), and the optimal concentrations are 500 pg / ml, 6 ng / ml and 200 ng / ml respectively. The composition is remarkably superior to a single factor and a high-dosage combination in the aspects of promoting BMSCs proliferation, improving the activity of alkaline phosphatase (ALP) and forming mineralized nodules, meanwhile, the use dosage of growth factors is remarkably reduced, and the risk of side effects such as heterotopic ossification is reduced. The composite growth factor composition has good biocompatibility and safety, and is suitable for the fields of bone tissue engineering, bone defect repair and related regenerative medicine.

The material for post-radiation bone repair comprises taurine and a covalent organic framework material, and the taurine is loaded on the covalent organic framework material and then dispersed in a dispersing agent. Through verification, the material disclosed by the invention has good biocompatibility, is in a flowing state when being heated to 52 DEG C and is in a solidification state after being cooled in an oral cavity, endows a bone defect area with retention force, and can stably and slowly release taurine for a long time and promote bone regeneration and repair for a long time in a radiated bone tissue.

The utility model discloses a metal 3D printing porous bone induction structure tibial prosthesis, which comprises a diaphysis prosthesis, a bone fracture plate and an intramedullary nail, the diaphysis prosthesis is designed according to the anatomical form of the focus part of a patient, the diaphysis prosthesis comprises a solid framework and a porous structure, and a cavity is arranged in the diaphysis prosthesis; the at least two bone fracture plates are connected to the two ends of the diaphysis prosthesis in the tibia direction respectively, and the at least two bone fracture plates are connected with the tibia near end and the tibia far end through screws respectively. The tibia near end comprises a first medullary cavity, the tibia far end comprises a second medullary cavity, the intramedullary nail penetrates through the first medullary cavity, the cavity and the second medullary cavity, and the two ends of the intramedullary nail are connected with the tibia near end and the tibia far end through screws respectively. The utility model can solve the problems of incapability of realizing rapid healing, poor initial stability and poor long-term stability in the existing bone defect reconstruction.

The application discloses a kind of biphasic bioactive tissue repair scaffolds and preparation method, comprising the following steps: step 1: calcium phosphate ceramic powder is modified on surface, and the modified calcium phosphate ceramic powder is obtained;Step 2: the modified calcium phosphate ceramic powder, potassium sodium niobate piezoelectric ceramic powder, dispersing agent, photoinitiator, photosensitive resin are mixed evenly, and the light-cured resin slurry is obtained after ball milling;Step 3: according to the design, 3D printing model is constructed, and the light-cured resin slurry is printed according to 3D printing model, and the scaffold body can be obtained;Step 4: scaffold body is cleaned, and the required scaffold can be obtained after defatting sintering;The application can prepare biphasic bioactive tissue repair scaffold with good mechanical properties, efficient antitumor ability and better bone regeneration capacity, and provide technical support for the repair of bone tumor postoperative bone defect in clinic.