3results about How to "Avoid stress shielding" patented technology

The invention provides a low-modulus, high-strength and high-plasticity Ti-Zr-Nb-Hf-Ta series biomedical alloy which comprises the following raw materials in atomic percent: 30-45% of titanium, 30-45% of zirconium, 5-15% of niobium, 5-20% of hafnium and 5-20% of tantalum, the # imgabs 0 # value of the biomedical alloy is 2.6-2.75 eV, the # imgabs 1 # value of the biomedical alloy is 2.92-3.06, and the valence electron concentration of the biomedical alloy is 4.1-4.3. The tensile elastic modulus of the biomedical alloy ranges from 54.6 GPa to 57.8 GPa, the yield strength of the biomedical alloy ranges from 885 MPa to 1061 MPa, and the ductility of the biomedical alloy ranges from 14.8% to 25.6%. The preparation method comprises the following steps: mixing titanium, zirconium, niobium, hafnium and tantalum to obtain a mixture; and then carrying out vacuum treatment, gas washing, smelting and cooling to obtain the alloy. The biomedical alloy is low in elasticity modulus and high in yield strength and ductility, and the problems of stress shielding, biological mechanical compatibility and the like can be effectively relieved.

The present invention discloses a method for generating a trabecular porous structure model based on cancellous bone micro-CT and preparing a trabecular porous structure, and relates to the field of biomedical technology. A specific implementation of the method for generating a trabecular porous structure model based on cancellous bone micro-CT includes: scanning the cancellous bone based on micro-CT to obtain a three-dimensional image of the cancellous bone; determining the position of the cavity of the cancellous bone according to the gray value of each point in the three-dimensional image; and generating a trabecular porous structure model based on the Voronoi algorithm according to the cavity position. This implementation can reproduce the microstructure, density distribution, mass transfer characteristics and biological properties of the bone, and at the same time has good mechanical properties and bone ingrowth properties.

This invention relates to a myocardial repair patch based on multi-material printing, its preparation, and its application, belonging to the field of bio-3D printing and regenerative medicine technology. The invention uses PLCL and GelMA hydrogel loaded with active cardiomyocytes as bio-inks, and introduces gelatin gel as a heat buffer material. An orthogonal network structure is constructed using multi-material bio-3D printing technology to prepare a myocardial repair patch with excellent dynamic adaptability to the myocardial interface and good biocompatibility. The myocardial injury repair patch prepared by this invention achieves a structure-function integrated design through the synergistic effect of the three materials, significantly overcoming the limitations of single materials in terms of mechanical properties, biological function, or thermal compatibility. The mechanical properties of the myocardial injury repair patch prepared by this invention can precisely match those of natural myocardium, while possessing high cell activity, effectively inhibiting fibrosis, improving myocardial function, and achieving true active repair. Furthermore, the process conditions are controllable, demonstrating good translational potential.