197 results about "Osseointegration" patented technology

The invention discloses a near-infrared light response titanium-based implant as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The near-infrared light response titanium-based implant provided by the invention comprises a porous titanium substrate, the TiO2 nanotube array is formed on the surface of the porous titanium substrate; the first photo-thermal coating layer is formed on the TiO2 nanotube array; the second photo-thermal coating is formed on the first photo-thermal coating; wherein the first photo-thermal coating is a ZIF-8 coating; and the second photo-thermal coating is a carbon nanotube coating. Through the double-layer photo-thermal system design of the ZIF-8 coating, the photo-thermal conversion efficiency is greatly improved, the controllable photo-thermal response capacity, the long-acting antibacterial and anti-tumor capacity and the dynamic osseointegration capacity are achieved, and the excellent osteosarcoma treatment effect is achieved.

The invention relates to the technical field of oral implantation guidance, and provides a digital false tooth mounting and positioning device based on three-dimensional scanning and a method thereof. The method comprises the following steps: scanning the oral cavity of a patient through an oral cavity scanner to generate a three-dimensional oral cavity digital model; generating a virtual implant of the patient and corresponding initial implantation parameters based on the three-dimensional oral cavity digital model through a SegFormer segmentation network; based on historical operation data, initial implantation parameters, bone density, patient attributes and occlusal force parameters, a long sequence prediction network is adopted to predict the position offset and bone resorption degree of the virtual implant after osseointegration through a segmented attention mechanism and a network memory cache mechanism, and optimal implantation parameters are obtained; and pushing a visual dynamic model containing the candidate positioning strategy to the user based on the optimal implantation parameter, driving an oral cavity model printer to obtain an implantation guide plate model and an oral cavity environment model, assisting the user in verifying the installation effect of the candidate positioning strategy, and improving the accuracy of false tooth installation and positioning.

The invention relates to the technical field of medical instruments, and discloses an angle-adjustable artificial hip joint prosthesis structure which comprises a thighbone connecting assembly, an acetabulum connecting assembly and a movable part movably connected between the thighbone connecting assembly and the acetabulum connecting assembly. The thighbone connecting assembly comprises a first connecting unit fixedly connected with the movable part, a thighbone stem detachably connected to the lower end of the first connecting unit, and a connecting screw fixedly connected to the upper end of the thighbone stem and in threaded connection with the first connecting unit. The acetabulum connecting assembly comprises a second connecting unit fixedly connected with the movable part and an acetabulum fixedly connected to the second connecting unit. Stable rotating connection is achieved through the double-shaft moving part, and a traditional easily-abraded spherical surface structure is replaced; the locking assembly is matched to realize personalized angle adjustment and locking; the femoral stem can be detached and replaced, and adaptability is improved; the surface composite coating promotes osseointegration and improves biocompatibility, the overall structure stability is high, adaptability is high, and postoperative recovery is fast.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The invention relates to a bone tumor repairing method based on three-dimensional reconstruction and a bionic structure. The method comprises the following steps: acquiring multi-modal medical image data of a bone tumor area of a patient to obtain an initial bone tumor three-dimensional model; generating a three-dimensional dynamic bone defect model for describing a bone tumor area based on the geometric structure of the initial bone tumor three-dimensional model; based on the three-dimensional dynamic bone defect model, generating a bionic implant three-dimensional model meeting bone defects; performing space alignment on the bionic implant three-dimensional model and the three-dimensional dynamic bone defect model to obtain a bone tumor repair model; carrying out restoration stability and osseointegration effect verification on the bone tumor restoration model to obtain a verification result; the verification result is used for indicating dynamic adjustment of the bionic implant three-dimensional model, and a final bone tumor repair three-dimensional model is obtained. By adopting the method, the accuracy, reliability and individuation level of bone tumor treatment can be improved.

The invention discloses a bionic heterogeneous composite structure bone implant and a preparation method thereof, and relates to the technical field of medical implants.The bionic heterogeneous composite structure bone implant comprises an inner-layer cross-shaped structure, a middle-layer negative Poisson's ratio structure and an outer-layer honeycomb structure, and the cross-shaped structure, the negative Poisson's ratio structure and the honeycomb structure jointly form a bionic composite structure; and immersing the bionic composite structure subjected to double-network crosslinking into a drug-containing solution for post-treatment and drug loading to obtain the bionic heterogeneous composite structure. According to the invention, bionic adaptation and intelligent optimization of mechanical properties are realized, and the stress shielding problem is solved; according to the invention, osseointegration and vascularization processes are obviously accelerated and enhanced, and leap-type improvement of biological activity is realized; a novel intelligent treatment mode based on in-vivo microenvironment response is developed, and on-demand and accurate drug delivery is achieved.

The present invention concerns a device (1) for restoring the integrity of the cranial bones, particularly of the non-resorbable type, comprising a plate body (3) in turn comprising a central body (5) and at least one peripheral portion (71), wherein said at least one peripheral portion (71) comprises fastening means (72) for fastening the device itself to the cranial bone (100), and wherein said cranial fixation device (1) comprises, at said central body (5), at least one insertion portion (50) protruding in a direction substantially orthogonal to said plate body (3) and which is configured to be inserted within a hole (102), drilled in the skull (100) of a patient, wherein said insertion portion (50) comprises a trabecular structure (51), suitable for stimulating bone regrowth and osseointegration of the device itself.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

The present disclosure includes fixation devices, such as an orthopedic screw or implant, that comprises one or more porous elements or fenestrations to aid in osteo-integration of the fixation device. The fixation device may be additively manufactured using biocompatible materials such that the solid and porous aspects of the screw are fused together into a single construct. In yet another aspect, the fixation device comprises at least a portion or section incorporating a porous structure, which enables bony ingrowth through the porous section / portion of the screw, and thereby facilitates biocompatibility and improve mechanical characteristics. Methods for using the fixation device are also described herein.

An orthopedic implant includes a main body, which has a downward tapered configuration formed of a plurality of steps of different diametrical sizes arranged along a drilling axis, each of the steps includes a cylindrical and a conical section, and the conical section of the lowest and diametrically smallest step is downward tapered into an apex; an external thread, which is externally formed on the main body to cover all the cylindrical sections but not the conical sections; a plurality of lateral cutting flutes, which are formed on the external thread into the main body and extended from the apex to the diametrically largest step with a spacing distance left between upper ends of the lateral cutting flutes and a top of the largest step. The orthopedic implant can be independently driven into a bone without the need of bone cutting using drill bits in advance and enables good osseointegration.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

The invention relates to a 3D printing porous metal-ceramic assembled composite implant as well as a preparation method and application thereof. The 3D printing porous metal-ceramic assembled composite implant comprises a porous metal-ceramic implant body formed by compounding a 3D printing integrated porous metal module and a 3D printing integrated porous ceramic module, the porous metal-ceramic implant body and the net-shaped metal protection body are arranged on the periphery of the porous metal-ceramic implant body in a wrapping mode, and the assembled composite implant can be accurately matched with the appearance and the combination surface of bone tissue of a defect part. The composite implant disclosed by the invention has osteogenesis environment regulation and control functionalization, and can achieve the effects of immediately recovering the movement function of defective bone tissue, improving the tissue microenvironment of a bone defect part, accelerating new bone regeneration and guiding new bone to grow towards the interior of the porous metal implant, so that rapid osseointegration of a bone / metal implant interface is realized; and the long-term treatment effect of 3D printing porous metal implant / autologous bone fusion type repair after ceramic degradation is achieved.

The invention relates to a time sequence degradable orthopedic implant material which comprises a base material and a biodegradable coating formed on the surface of the base material, the surface of the base material is provided with a nanocone array microstructure, the biodegradable coating takes a biodegradable polymer as a matrix and loads a metal element for promoting bone repair, and the metal element is a metal element for promoting bone repair. And the surface of the biodegradable coating is also connected with an anti-inflammatory active factor. According to the invention, grafted anti-inflammatory active factors are matched with the biodegradable coating loaded with metal elements for promoting bone repair, and the sequential active regulation and control of the biological effect of the micro-morphology on the surface of the base material cope with effector cells in different repair stages; the time sequence regulation and control on the macrophage inflammation phenotype and bone marrow mesenchymal stem cell osteogenic differentiation in different stages of bone repair are realized, so that each stage of bone tissue repair is matched, and bone repair and osseointegration are promoted.

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.

An implantation kit including a rotational osteotome and an implant is disclosed. The rotational osteotome includes a plurality of steps of different diametrical sizes, a tip, and at least one flute; and every step includes an annular bottom bevel to provide a cutting edge and recessed section. The implant includes a body having a cylindrical head section and a conical section provided with an external thread and a plurality of spiral flutes. The conical section has a downward tapered profile correspondingly aligned with the recessed sections. The cylindrical head section has a straight cylindrical profile matching that of the step having the largest diametrical size. With the above arrangements, an implant hole on a bone can be formed in only one drilling with one single osteotome for fixedly holding the implant therein. Therefore, the time needed for dental and orthopedic surgeries is largely shortened while better osseointegration can be achieved.

The invention provides an artificial prosthesis assembly for an ankle joint replacement operation, and belongs to the technical field of ankle joint prostheses. Comprising a talus arc plate, an arc-shaped guide rail is installed at the top of the talus arc plate, rivets are installed in the talus arc plate, a joint soft plate is connected to the top of the arc-shaped guide rail in a sliding mode, and a tibia installation plate is installed above the joint soft plate; and a rivet fixing assembly is mounted at the top of the tibia mounting plate. By arranging the elastic adjusting assembly and the sliding lubricating assembly, the contact area with bone tissue can be remarkably increased, the initial stability of the prosthesis is enhanced, the separation risk of the prosthesis is reduced, and the elastic relaxation degree of the prosthesis is adjusted and controlled, so that the modulus of the prosthesis is dynamically matched with the bone elasticity of a patient, and the bone interface stress concentration risk of the prosthesis is reduced; meanwhile, the movement resistance of the prosthesis is reduced through ball lubrication, material fatigue and loss caused by dry friction between the prostheses are avoided, and the service life of the prosthesis is prolonged.

An implant system has an acetabular cup with an interior bearing surface with a central bearing zone that is smooth and devoid of holes or indentations. The cup also has a peripheral bearing zone that contains insertion tool engagement holes. The engagement holes are only present in the peripheral zone and have specific shapes and dimensions. The system includes an insertion tool with retractable interlocks that fit within the engagement holes to position the cup during implantation. The central bearing zone bears the main forces during articulation, while the peripheral zone withstands minor forces. The location of the engagement holes has a negligible effect on the cup's performance. The cup can be made of ceramic and may have a coated exterior surface for osseointegration.

The invention discloses a coating deposition process for an implant, and relates to the technical field of implant coating preparation, and the deposition process comprises the following steps: S1, base material pretreatment: placing a base material in a deionized water mixed solution for ultrasonic cleaning, adopting low-temperature plasma purification treatment, utilizing high-energy particles of plasma to bombard the base material, and using the high-energy particles of the plasma to bombard the base material; the preparation method comprises the following steps: removing surface and internal impurities, introducing active groups, forming a nanoscale rough interface with the surface roughness Ra of 50-200nm on the surface of a base material through a chemical etching process and femtosecond laser etching synergistic process, and carrying out vacuum drying on the base material; s2, metal gasification: placing a metal tantalum raw material in an upstream heating zone of the reaction chamber; the chemical vapor deposition (CVD) technology is adopted, osseointegration can be promoted, the infection risk can be reduced, the method is suitable for porous implantation instruments of the orthopedics department, the dental department and the like, the obtained coating technology is compatible with a complex base material structure, the clinical curative effect and the life quality of a patient are improved, large-scale production is supported, and development of a new material industry chain is promoted.

A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and / or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and / or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

The invention discloses a preparation method of an active coating of a surgical titanium alloy fusion cage. The preparation method comprises the following steps: S1, preparing a titanium alloy fusion cage with a porous structure through 3D printing; s2, constructing a polydopamine coating on the surface of the titanium alloy fusion cage; s3, preparing a calcium phosphorus deposition solution, and performing hydroxyapatite mineralization on the polydopamine coating; and S4, grafting TBMP2 protein on the surface of the hydroxyapatite mineralized coating to complete the preparation of the titanium alloy fusion cage active coating. The problems that an existing titanium alloy fusion cage is poor in biological inertness and osseointegration performance and has many side effects in BMP2 application are solved, and the titanium alloy fusion cage can adapt to personalized implantation requirements.

This invention relates to the field of biomedical technology, specifically to a biomimetic piezoelectric scaffold for promoting bone repair, its preparation method, and its applications. The biomimetic piezoelectric scaffold provided by this invention is produced by electrospinning PLLA into oriented nanofibers, and then modifying the fiber surface with nano-hydroxyapatite. To enhance the adhesion of hydroxyapatite to the fiber surface, a polydopamine layer is modified between the two as a connecting layer, ultimately resulting in a biomimetic piezoelectric scaffold with high porosity, good osteointegration, and osteogenic promoting effects. This scaffold exhibits good bone regeneration promoting effects in in vitro MSC recruitment, osteogenic differentiation experiments, and repair of skull bone defects in rats.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

The present application belongs to the field of biomedical materials and computer aided design technology, and discloses a kind of porosity gradient adjustable hip joint prosthesis porous coating topological optimization method.The present application is aimed at solving the problems of existing design, such as unadjustable porosity distribution, gradient mutation, difficult to balance mechanical properties and bone integration, and the gap between topological optimization and manufacturing constraints.The method introduces nonlinear porosity gradient constraints and adaptive optimization mechanism in the process of topological optimization through the steps of geometric modeling and boundary condition definition, nonlinear porosity gradient field generation, finite element analysis, sensitivity analysis, density filtering and porosity constraint processing, optimization criterion updating and convergence judgment, and realizes the smooth transition of porosity from the core to the surface of the prosthesis.The present application can optimize the mechanical support and biological integration performance simultaneously, eliminate non-manufacturable structures, and adjust the gradient parameters and modularize the extension, providing an efficient and reliable calculation method for personalized hip joint prosthesis design, and having significant engineering and clinical application value.

The application provides an artificial prosthesis assembly for ankle replacement surgery, and belongs to the technical field of ankle prosthesis. The artificial prosthesis assembly comprises a talus arc plate, a circular arc guide rail is arranged on the top of the talus arc plate, a rivet is arranged in the interior of the talus arc plate, a joint soft plate is slidably connected to the top of the circular arc guide rail, and a tibial mounting plate is arranged above the joint soft plate; a rivet fixing assembly is arranged on the top of the tibial mounting plate. The elastic adjusting assembly and the sliding lubricating assembly are arranged, so that the contact area with the bone tissue is significantly increased, the initial stability of the prosthesis is enhanced, the risk of prosthesis separation is reduced, the prosthesis modulus is dynamically matched with the bone elasticity of the patient through the regulation of the elastic relaxation degree of the prosthesis, the risk of stress concentration of the prosthesis bone interface is reduced, the success rate of bone integration is improved, meanwhile, the prosthesis activity resistance is reduced through the ball lubrication, material fatigue and loss caused by dry friction between the prostheses are avoided, and the service life of the prosthesis is prolonged.

The invention discloses a titanium metal dental implant and a processing method thereof, and belongs to the technical field of medical instruments, the surface of an implant part of the implant is provided with a composite bioactive layer, and the composite bioactive layer is formed by compounding a first-stage micron hole layer formed by selective laser micro-melting and a second-stage submicron-nano mesh hole layer formed by micro-arc oxidation, and the secondary pore layer has gradient distribution of bioactive elements such as calcium and phosphorus. The processing method comprises the steps of matrix pretreatment, construction of a micron structure through selective laser micro-melting, synchronous construction of a nano structure through micro-arc oxidation, element gradient doping and post-treatment. The surface of the prepared implant has a unique micron-nano graded composite pore structure and gradient distribution of bioactive elements, the mechanical stability and the biological activity of the implant can be synergistically promoted, rapid and stable osseointegration is realized, the processing method is green and controllable, and the implant has a good application prospect.

A cervical fusion implant with serrations and radio opaque marking and a method thereof is disclosed The cervical fusion implant is optimized for enhanced spinal stabilization and integration. The cervical spine fusion implant is constructed from polyether ether ketone, known for its exceptional durability and biocompatibility. The implant is designed with a robust body encased in a protective capsule. The design ensures superior structural integrity and functional utility. The implant incorporates a self-stabilizing screw assembly featuring at least four lateral surfaces, each with slits to promote bone growth and integration. Additionally, the anterior surface is equipped with a screw hole for secure fixation using a titanium screw. This combination of features aims to improve spinal stabilization, promote effective fusion, and ensure long-term implant performance. Furthermore, the implants assist to maintain normal cervical curvature of the patient.

The application relates to a three-dimensional adjustable bone-integrated half-pelvis prosthesis, which comprises a split assembled customized sacrum bone-integrated base, an acetabular cup assembly, a customized pubic bone-integrated base, a sacrum side pelvis ring support assembly and a pubic side pelvis ring support assembly; one end of the customized sacrum bone-integrated base is connected with the sacrum, and the other end is connected with the acetabular cup assembly through the sacrum side pelvis ring support assembly; one end of the customized pubic bone-integrated base is connected with the healthy pubic bone, and the other end is connected with the acetabular cup assembly through the pubic side pelvis ring support assembly; when the acetabular cup assembly, the sacrum side pelvis ring support assembly and the pubic side pelvis ring support assembly are assembled, the anteversion angle of the acetabular cup assembly can be adjusted relative to the sacrum side pelvis ring support assembly and the pubic side pelvis ring support assembly. The half-pelvis prosthesis and the pelvis of the patient constitute a complete and stable pelvis ring structure, the stability of the half-pelvis prosthesis is improved, and the accuracy and convenience of the prosthesis installation during the operation are greatly improved.

The invention belongs to the technical field of medical materials, and discloses a novel titanium-based implant material with oxygen-releasing, antibacterial and osteogenesis-promoting properties and a preparation method of the novel titanium-based implant material. The titanium-based implant material comprises a titanium substrate and calcium peroxide on the surface of the titanium substrate. The invention provides a method for modifying a compact or porous titanium-based implant material by using calcium peroxide. The characteristic that calcium peroxide reacts with water to release oxygen, hydrogen peroxide and calcium ions and the biological activity of calcium ions in the aspect of bone repair enable the titanium-based implant material to have application potential in the aspects of preventing / relieving / treating implant bacterial infection, large-size bone defect oxygen supply insufficiency and poor osseointegration.

The invention discloses a preparation method of a nano copper selenide antibacterial peptide-loaded multistage microporous titanium alloy. The preparation method comprises the following steps: 1, preparing a substrate; 2, surface modification; and 3, carrying out functionalization treatment to obtain the multistage microporous titanium alloy loaded with the nano copper selenide antibacterial peptide. The invention further provides the multistage microporous titanium alloy loaded with the nano copper selenide antibacterial peptide. The load design and photo-thermal synergistic mechanism of the nano copper selenide antibacterial peptide-loaded multistage microporous titanium alloy can effectively inhibit bacterial breeding and greatly reduce the infection risk of implantation operations, and on the aspect of promoting osseointegration, the multi-scale structure and ion slow release design can accelerate bone tissue growth and material fusion and reduce long-term complications, so that the titanium alloy can be used as a medical material for treating osteoporosis. The bone repair microenvironment is optimized, a new thought, good stability and safety are developed for complex disease treatment, long-term stable effect in vivo is guaranteed, strict standards are met, a solid foundation is laid for large-scale clinical application, and the bone implantation medical field is expected to be innovated.

The invention discloses a silicon nitride ceramic composite material for an interbody fusion device and a preparation method thereof, the composite material is composed of silicon nitride, liquid metal gallium and an osseointegration induction element, and the method comprises the following steps: preparation of basic components, sintering of the basic components, preparation of final components, and sintering of the final components. The ceramic composite material prepared by the preparation method disclosed by the invention has excellent biological activity, can promote inward growth of bone tissues, has good osteoconductivity and osteoinductivity, and also has good biomechanical properties. In addition, the preparation process provided by the invention is simple and convenient, is high in controllability and has a wide application prospect.