31 results about "Osseointegration" patented technology

This invention relates to the field of biomedical technology, specifically to a biomimetic piezoelectric scaffold for promoting bone repair, its preparation method, and its applications. The biomimetic piezoelectric scaffold provided by this invention is produced by electrospinning PLLA into oriented nanofibers, and then modifying the fiber surface with nano-hydroxyapatite. To enhance the adhesion of hydroxyapatite to the fiber surface, a polydopamine layer is modified between the two as a connecting layer, ultimately resulting in a biomimetic piezoelectric scaffold with high porosity, good osteointegration, and osteogenic promoting effects. This scaffold exhibits good bone regeneration promoting effects in in vitro MSC recruitment, osteogenic differentiation experiments, and repair of skull bone defects in rats.

The present application belongs to the field of biomedical materials and computer aided design technology, and discloses a kind of porosity gradient adjustable hip joint prosthesis porous coating topological optimization method.The present application is aimed at solving the problems of existing design, such as unadjustable porosity distribution, gradient mutation, difficult to balance mechanical properties and bone integration, and the gap between topological optimization and manufacturing constraints.The method introduces nonlinear porosity gradient constraints and adaptive optimization mechanism in the process of topological optimization through the steps of geometric modeling and boundary condition definition, nonlinear porosity gradient field generation, finite element analysis, sensitivity analysis, density filtering and porosity constraint processing, optimization criterion updating and convergence judgment, and realizes the smooth transition of porosity from the core to the surface of the prosthesis.The present application can optimize the mechanical support and biological integration performance simultaneously, eliminate non-manufacturable structures, and adjust the gradient parameters and modularize the extension, providing an efficient and reliable calculation method for personalized hip joint prosthesis design, and having significant engineering and clinical application value.

The present discussion relates to the design fabrication and use of synthetic scaffold structure for bone growth. In certain implementations the scaffold structures are comprised of a plurality of repeating structures each defined by a local topology. The local topologies are defined at a subset of points in their respective volumes by various parameters including, but not limited to, shape index, curvedness, mean curvature, and Gauss curvature.

This invention belongs to the field of foot and ankle joint replacement implant technology, and discloses an ankle joint talus prosthesis with an antibacterial porous interface and its preparation method. It includes a prosthesis substrate with an overall anatomically contoured structure, including a superior articular surface, a inferior articular surface, and an anterior articular surface; the area of ​​the prosthesis substrate in contact with residual bone tissue is designed as a three-dimensional porous structure; an antibacterial bioactive composite coating is grown in situ on the surface of the prosthesis substrate; it includes calcium and phosphorus bioactive components and antibacterial ions. This invention, by constructing an antibacterial bioactive composite coating at a porous bone integration interface, utilizes biocompatibility and osteoconductivity to induce bone tissue growth. Furthermore, the antibacterial ions can be slowly and continuously released in the interstitial spaces, achieving a dual function of promoting bone integration and preventing infection. Moreover, the antibacterial bioactive composite coating is formed through in-situ growth, resulting in a strong bond with the substrate and preventing detachment.

The present application belongs to the technical field of surgical implant medical devices for foot and ankle, and discloses a preset angle ankle arthrodesis device with functions of promoting bone integration and resisting bacteria, which has a preset angle suitable for tibiodal joint, ranging from 3° to 7°. The device further comprises a three-dimensional porous bone implant body, a surface of the three-dimensional porous bone implant body in contact with host bone tissue is a porous titanium alloy, a plurality of convex anti-rotation ridges are arranged on the upper and lower end faces of the three-dimensional porous bone implant body, the three-dimensional porous bone implant body is fixed by occlusion with the host bone through the anti-rotation ridges, an in-situ growth film layer is grown on the surface of the three-dimensional porous bone implant body, and the in-situ growth film layer comprises functional substances and antibacterial substances. The present application effectively solves the technical problems of slow bone integration, high risk of infection, rotation instability and insufficient mechanical support in ankle arthrodesis, significantly improves the success rate of fusion and reduces postoperative complications.

This invention belongs to the field of biomaterials technology, specifically relating to a porous metal-ceramic composite scaffold for bone repair in diabetes and its preparation method. This invention uses tetrapodized zinc oxide as a three-dimensional stable pore-forming template, constructing an overall preparation route of "high-energy ball milling – t-ZnO template – SPS – etching," achieving uniform composite of high-melting-point metal and bioactive ceramic. This results in a porous metal-ceramic composite scaffold with uniform tissue structure, strong interfacial bonding, controllable pore structure, adjustable mechanical properties, and multiple bioactivities including osteogenic, immunogenic, and vascularization activities, significantly improving post-implantation bone integration efficiency and biofunctionality.

The present application relates to a kind of helical gradient lattice structure design method and medium, it is related to the lattice structure design technical field based on computer processing.The method comprises the following steps: constructing outer contour, introducing logarithmic spiral function to establish the array path of parameter curve, establishing double-lattice composite structure as the basis of lattice structure growth, gradient design is carried out on the basis of lattice composite structure, including: sequentially each point in array path is designed, lattice size parameter design and lattice structure porosity design are carried out to strut parameter;The core structure and peripheral structure of connecting interface are obtained, and the model obtained by modeling is obtained.The mechanical properties of helical gradient lattice structure are improved, the pore connectivity and distribution law are optimized, so that the layer-by-layer increasing of porosity and the continuous transition of double-layer structure interface connection are realized, the material utilization efficiency is improved while guaranteeing the stability of structure, cell migration and bone tissue growth path are effectively guided, and the bone integration ability of scaffold is optimized.

A computerized system and method (123A-C) for the automated design and additive manufacturing of patient-specific orthopedic reconstructions (600R). The method integrates anatomically tagged medical scans, oriented relative to X, Y, and Z axes, with machine-learning models trained on aggregate historical biomechanical outcomes to generate optimized implant geometries. The system calculates an Osseointegration Probability Score (OPS) and a Comprehensive Prognostic Success Score (CPSS) to dynamically modify internal porous lattice densities, minimizing stress shielding while maximizing load-bearing capacity. The manufacturing process simultaneously generates internal longitudinal conduits for post-operative vascularization and computationally optimized structural anchors (bulges, serrations, and wings) for precise anatomical fixation. By linking real-time biomechanical simulation with prognostic clinical data, the invention provides a high-fidelity manufacturing blueprint that improves long-term implant stability and reduces periprosthetic complications.

This invention discloses a method for simultaneously predicting the microstructure and processing stability of robot-milled surfaces for bio-implants, belonging to the fields of high-end medical device manufacturing and biomedical engineering technology. It includes establishing a non-homogeneous dynamic model that considers regeneration effects and retains static cutting force terms as non-homogeneous excitations, tailored to the characteristics of robot processing of biomaterials; using a semi-discretization method to discretize the cutting cycle and derive the state-space affine transformation relationship within a cutting cycle; and improving the clinical success rate of implants from the manufacturing stage by accurately selecting process parameters that are both chatter-free and generate optimal osseointegration textures before code execution. Furthermore, by directly solving for steady-state fixed points using analytical matrix operations, it replaces traditional long-cycle time-domain simulation, increasing computation speed by tens of times, making it highly suitable for large-scale, rapid process verification of personalized implants.

A thermally balanced filler bone graft scaffold includes a scaffold shell and a base. The scaffold shell has an inner cavity. The base has a multi-purpose chamber at its tail end and a heat convection tube assembly at its head end. The multi-purpose chamber is connected to the surface of the head end of the base via the heat convection tube assembly. The heat convection tube assembly connects the inner cavity of the scaffold shell with the multi-purpose chamber of the base. This provides a stable support base, promotes the bone integration process, achieves thermal balance of the overall scaffold, appropriately increases the internal temperature of the femoral head, accelerates local blood circulation in the femoral head, enhances cell activity, accelerates metabolism, promotes the proliferation and differentiation of osteocytes and other related cells, promotes angiogenesis and bone repair, facilitates gas exchange, promotes the drainage of effusion and gas, continuously releases intraosseous pressure, and provides storage space and pathways for therapeutic drugs and / or nutrients. This implant achieves multi-system synergy and promotes overall rehabilitation.

The present disclosure includes an orthopedic device, such as an implant, that comprises one or more latticed regions to aid in fusion or osteo-integration between the implant and a specific patient. The implant may have periodic, organic, hybrid lattice structures or a combination thereof to further facilitate biocompatibility and improve mechanical characteristics of the implant. Methods for fabricating a customized device are also described herein.

The application discloses a gradient biomimetic PEEK-HA-Col I composite implant and a preparation method and application thereof, relates to the technical field of medical biomaterials, and has the following scheme: a composite implant composed of a load-bearing inner layer, a bioactive intermediate layer and a biomimetic bone matrix layer is constructed; the load-bearing inner layer contains a PEEK matrix, the intermediate layer contains PDA modified interfaces and HA induced and deposited by the interfaces, and the outer layer contains cross-linked modified collagen type I, and a bioactive gradient distribution is formed along the thickness direction; the preparation method and the application of the composite implant in bone repair are simultaneously provided. The application improves the interface bioactivity and the bone integration capability on the basis of maintaining the PEEK load-bearing support, improves the interface structure stability and the bioactive spatial distribution, improves the surface hydrophilicity and the interface microenvironment, is favorable for promoting early osteogenesis and bone defect repair, improves bone fusion and application adaptability in a load-bearing bone implantation scene, and simultaneously considers the synergistic matching of the load-bearing demand and the biological demand of the bone tissue interface.

Provided herein are implants and methods for producing implants. In at least one embodiment, the implants include sheet-based, triply periodic, minimal surface (TPMS) portions. According to one embodiment, the TPMS portions include a gyroid architecture that provides for improved osseointegration and mechanical performance over previous implants due to novel ratios of porosity to compressive strength, among other features. In one or more embodiments, the gyroid architecture is organized into unit cells that demonstrate anisotropic mechanical performance along an insertion direction. In various embodiments, the present methods include novel selective laser melting (SLM) techniques for forming the TPMS portions of implants in a manner that reduces defect formation, thereby improving compressive performance and other implant properties.

This invention discloses a locking bone plate, its preparation equipment, and a preparation method. The locking bone plate includes a bone plate body, a multi-directional micro-motion locking component, a gradient bioactive coating, a stress buffer structure, and a bone-inducing positioning component. The surface of the bone plate body has an anatomically conforming curved surface, with locking holes and micro-motion holes arranged alternately along its length, and a stress buffer structure in the middle. The multi-directional micro-motion locking component is assembled in the micro-motion holes, enabling multi-directional angle adjustment and axial micro-motion of the locking screws. The gradient bioactive coating fully covers the surface of the bone plate body and the walls of each hole, employing a three-layer structure. The bone-inducing positioning component is located on the bone side of the bone plate body that conforms to the bone, used to assist fracture reduction and induce bone cell growth. This invention achieves an organic combination of rigid fixation and multi-directional micro-motion, enhancing bioactivity and bone integration capabilities. It can adapt to complex fracture morphologies, reduce stress shielding, accelerate bone healing, and is safe to use and easy to assemble, possessing extremely high clinical application value.

The present application belongs to the field of medical engineering technology, especially an integrated bionic gradient porous titanium alloy femoral stem, aiming at the problem that the existing implant lacks adaptive design for the anatomical form and functional partition of the femur, leading to mismatch of mechanical properties, easy to cause stress concentration, stress shielding and poor bone integration, the following scheme is proposed, which comprises a fixing device and a bracket, the fixing device and the bracket are connected, the fixing device and the bracket are integrally formed by three-dimensional printing; the present application realizes the precise matching of the mechanical properties of the bracket and the different regions of the femur through the integrated bionic gradient porous structure design, effectively avoids stress shielding and induces bone growth; at the same time, the stress state and the interface micro-motion of the bracket can be monitored in real time, and the data can be sent to the external receiving equipment, realizing dynamic evaluation and early warning of the postoperative bone healing process, thereby significantly improving the initial stability, long-term survival rate and personalized rehabilitation level of the implant.

The application relates to the technical field of orthopedic artificial joint, in particular to an integrated unicompartmental prosthesis system and a preparation method of the integrated unicompartmental prosthesis system. The integrated unicompartmental prosthesis system comprises a femoral condyle prosthesis, a tibial plateau prosthesis and a tibial plateau pad prosthesis; the femoral condyle prosthesis and the tibial plateau prosthesis are both made of a zirconium niobium alloy 3D printing; the tibial plateau pad prosthesis is made of a zirconium niobium alloy 3D printing or a zirconium niobium alloy forging; the upper surface of the femoral condyle prosthesis is in contact with the tibial plateau pad prosthesis, and the upper surface of the tibial plateau prosthesis is in contact with the lower surface of the tibial plateau pad prosthesis. The bone integration interfaces of the integrated unicompartmental prosthesis system are all formed by zirconium niobium alloy trabecular structures, and the friction contact surfaces between the prostheses are all metal ceramic interfaces formed by zirconium niobium surface oxidation, so that the bone resection amount of the tibial plateau can be reduced, the wear resistance of the friction interface can be improved, the wear debris of the friction interface can be greatly reduced, and the stability of the prosthesis in the later period is improved.

The application discloses a knee joint prosthesis system and a preparation method, wherein the femoral condyle prosthesis, the tibial plateau pad prosthesis, the tibial plateau prosthesis and the patellar prosthesis are made of zirconium niobium alloy, so that the sliding friction contact surfaces of the tibial plateau pad prosthesis, the patellar prosthesis and the femoral condyle prosthesis are metal ceramic interfaces formed by oxidation of zirconium niobium surfaces, the wear rate is lower, the active wear of the joint prosthesis can be effectively reduced, the service life of the joint prosthesis is prolonged and the failure rate is reduced, meanwhile, the risk of osteolysis caused by debris generated by wear of a traditional prosthesis due to an ultra-high molecular weight polyethylene tibial plateau pad prosthesis, and further triggering the risk of loosening of the prosthesis, can be avoided. Moreover, the bone integration interfaces of the femoral condyle prosthesis, the tibial plateau prosthesis and the patellar prosthesis are zirconium niobium alloy trabecular structures, so that the zirconium niobium alloy trabecular structures have excellent biocompatibility, are convenient to combine with the bone tissue of a patient and can improve the bone integration efficiency of the frame body and the bone tissue.

[ABSTRACT] The present invention relates to a glass ceramic composition comprising SiO2, Ca(OH)2, CaF2, B2O3, MgO, and hydroxyapatite; a bioactive crystallized glass ceramic comprising each of CaSiO3, Ca10(PO4)6(OH)2, and CaMgSi2O6 in an amount of 20% to 60% by weight; an implant for early osseointegration comprising the glass ceramic; and a method for manufacturing the implant. [ABSTRACT] The present invention relates to a glass ceramic composition comprising SiO2, Ca(OH)2, CaF2, B2O3, MgO, and hydroxyapatite; a bioactive crystallized glass ceramic comprising each of CaSiO3, Ca10(PO4)6(OH)2, and CaMgSi2O6 in an amount of 20% to 60% by weight; an implant for early osseointegration comprising the glass ceramic; and a method for manufacturing the implant. 1 / 5 [DRAWINGS] [Fig. 1] [Fig. 2] 1 / 5 [DRAWINGS] [Fig. 1] Hydroxylapatite=53.2% Wollastonite-2M=20.8% Diopside=26.0% Wt% [Fig. 2] Na not included, Wollastonite # Diopside Sintered at 1050°C Na not included, SiO 2 Sintered at 970°C Same Phase Na included, Wollastonite # Diopside Sintered at 970°C 20 25 30 35 40 2 Theta (deg) CuKa This data, for application number 2019462312, is current as of 2026-06-05 08:40 AEST Wollastonite-2M=20.8% Diopside=26.0% Wt% Intensity (Arb. unit) Same Phase Sintered at 970°C 20 25 30 35 40 20 26 20 52 96 06 J ul 2 02 6 2 0 2 6 2 0 5 2 9 6 0 6 J u l 2 0 2 6 W o l l a s t o n i t e - 2 M = 2 0 . 8 % W t % I n t e n s i t y ( A r b . u n i t ) S a m e P h a s e S i n t e r e d a t 9 7 0 ° C 2 0 2 5 3 0 3 5 4 0

The present invention pertains to the field of biomaterials for covering and protecting bone grafts / biomaterials, and relates more specifically to a titanium mesh covered with a biocompatible polypropylene film that aims to increase bone volume using biomaterials or using grafts in their most varied forms, such as autogenous bone (bone from the individual), allogenous bone (bone from other individuals of the same species), and xenogenous bone (bone from individuals of a different species) for the subsequent installation of osteointegrated implants. When the claimed mesh protected with a polypropylene film is used, with the film blocking the holes, the materials used to increase the volume do not pass through the holes of the mesh, as they are blocked by the polypropylene film, making these meshes 100% waterproof. This makes it easy to remove the mesh and, as there is no penetration of material through the holes, the implants are installed over a large amount of bone tissue. When using the titanium mesh with the polypropylene film, in contrast to when it does not have this protection, it does not need to be completely covered by surgical flaps, facilitating the surgical technique and thus avoiding post-operative complications due to exposure that often occurs with unprotected meshes. In addition, it is advantageous that the mesh can be kept intentionally exposed to the mouth environment, placed over the materials used to achieve bone volume augmentation, regardless of the materials used underneath it, whether grafts or biomaterials (synthetic materials). This brings greater comfort to the patient, as it provides a post-operative period with very low morbidity and a rapid recovery.

This invention discloses an antibacterial and bioactive composite film layer on the surface of a zirconium-based amorphous alloy, its preparation method, and its application, belonging to the technical field of biomedical zirconium alloy coating materials. Hydroxyapatite nanoparticles and strontium are introduced into the micro-arc oxidation process. Hydroxyapatite (HA) possesses excellent osteoconductivity, osteointegration capacity, osteoinductive properties, and biocompatibility; strontium plays a unique role as a "bidirectional regulator of bone metabolism" in biomedical materials. Furthermore, the incorporation of Cu endows the micro-arc oxidation film layer with broad-spectrum and long-lasting antibacterial capabilities. This invention generates a composite film layer with both antibacterial and bioactive properties on the surface of a zirconium-based amorphous alloy through a single micro-arc oxidation step, enhancing its overall service performance in physiological environments.

The application discloses a synthetic method of a composite coating and application of the composite coating to a surface of an artificial bone, and belongs to the technical field of biomaterials.The synthetic steps of the composite coating are as follows: firstly, the artificial bone substrate is cleaned and subjected to oxygen plasma activation pretreatment; secondly, polyether ether ketone is dissolved in N-methyl pyrrolidone, mixed with tantalum-doped lithium zirconate nanowires and a dispersing agent, and subjected to ultrasonic treatment to form a coating slurry; the coating slurry is formed into a wet film on the substrate by dip-coating; and finally, the wet film is subjected to step-by-step heat treatment and solidification to obtain the composite coating.The preparation steps of the nanowires are as follows: zirconium ethoxide, tantalum ethoxide and lithium methoxide are used as precursors, and a precursor sol is obtained through a sol-gel reaction under the control of water quantity; the nanowires are grown through a hydrothermal reaction combined with a morphology directing agent; and finally, the nanowires are washed, dried and calcined to obtain the final product.The method has simple process, and the obtained coating has excellent biocompatibility, mechanical strength and potential bioactivity, is suitable for surface modification of an artificial bone implant, and can effectively promote bone integration.

Artificial socket (10) for a joint implant, wherein the socket (10) comprises a cup-shaped base body (12) with a rim (20) and a pole (24), and wherein the base body (12) has engagement elements (36) projecting towards the bone on an outer surface (14) facing a bone in the insertion position, wherein the base body (12) is coated at least partially on the outer surface (14) with an osteointegrative coating (56), wherein the engagement elements (36) have a first side surface (48) facing a plane (32) defined by the rim (20), and a second side surface (50) facing the bone, characterized in that the coating (56) on the first side surface (48) is thinner than on the second side surface (50) and / or that the engagement elements (36) are coated at least partially in such a way thatthat the coating (56) extends beyond the coating (56) on the first side surface (48) at its free ends in the direction of a plane (32) defined by the edge (20) and the engagement elements (36) with the coating (56) applied to them form an undercut (58) in a direction transverse to the plane (32).

A bone implant and a dental implant assembly. The bone implant comprises a tapered thread structure, wherein the tapered thread structure extends from a coronal end (110) to an apical end (160) along the central longitudinal axis of the implant; the tapered thread structure comprises a core portion (140) and a tapered thread extending radially outwards along the core portion (140); the tapered thread comprises an apical flank (262), a coronal flank (261), and a lateral surface (263) connecting the apical flank (262) and the coronal flank (261); the lateral surface (263) defines a radially outer surface of the thread; the thread helically extends in the direction of the central longitudinal axis; and on at least one section of the range of the central longitudinal axis, an included angle formed by the apical flank (262) and the coronal flank (261) gradually increases in a direction from the apical end (160) to the coronal end (110). The bone implant facilitates bone attachment, has a large load-bearing area, achieves an expected mechanical effect by means of small bone compression per unit area, reduces damage to bone cells and blood vessels, improves primary stability after implantation of the implant and accelerates osseointegration, and is suitable for immediate implantation.

The present application belongs to the technical field of orthopedic medical instruments, and discloses a subtalar joint fusion device with a calcium-phosphorus antibacterial ion composite coating and a preparation method. The subtalar joint fusion device with the calcium-phosphorus antibacterial ion composite coating comprises an arc-shaped base body, and the whole presents a curved structure matched with the anatomical morphology of the subtalar joint, and the curvature radius is adjustable. The arc-shaped base body has a three-dimensional porous structure. A composite functional coating is in-situ grown on the surface of the arc-shaped base body. The active of the composite functional coating on the upper and lower surfaces of the arc-shaped base body is different, so as to promote bone integration and long-acting antibacterial dual functions. The calcium-phosphorus bioactive components and zinc and silver antibacterial ions are integrated in the same in-situ growth film layer, so that the subtalar joint fusion device has excellent bone induction activity and strong antibacterial function. Through the use of the gradient coating with different activities, the precise matching of the function and the anatomical requirement is further realized, and the subtalar joint fusion scene is suitable.

This invention relates to the field of bone repair technology, specifically to drug-loaded microsphere-modified porous calcium phosphate bone cement, its preparation method, and repair material. The solid phase of the porous calcium phosphate bone cement consists of a porous calcium phosphate bone cement matrix and drug-loaded microspheres dispersed therein. The porous calcium phosphate bone cement matrix has a three-dimensional interconnected pore structure, and the drug-loaded microspheres have a core-shell structure, with the outer shell being a biodegradable material and the core being a osteoinducing factor. This porous calcium phosphate bone cement utilizes porous CPC to provide space for bone integration, and the drug-loaded microspheres achieve long-term controlled release of the osteoinducing factor, achieving efficient bone defect repair through an integrated "bone conduction-bone induction-bone integration" process.

DENTAL IMPLANT APPARATUS FOR OSSEOINTEGRATION

This invention relates to the field of medical material manufacturing technology, and more specifically, to a photothermally controllable antibacterial titanium alloy implant and its preparation method. The implant substrate is titanium or a titanium alloy, and its surface is activated by alkaline heat treatment. Polydopamine and copper ions are polymerized in situ at room temperature to coat the implant substrate surface. The implant obtained by this invention has no significant toxicity to osteoblasts, excellent biocompatibility, and combines multiple functions such as synergistic antibacterial activity, high hydrophilicity, osteopromoting properties, photothermally controllable properties, and safe sustained release. It can be widely applied in medical implantation fields such as orthopedic implants, bone fixation devices, and cardiovascular stents, providing a safe, efficient, and feasible new solution for effectively addressing key issues such as clinical infection and poor osseointegration in medical titanium alloys.

The present application relates to a kind of helical gradient lattice structure design method and medium, it is related to the lattice structure design technical field based on computer processing.The method comprises the following steps: constructing outer contour, introducing logarithmic spiral function to establish the array path of parameter curve, establishing double-lattice composite structure as the basis of lattice structure growth, gradient design is carried out on the basis of lattice composite structure, including: sequentially each point in array path is designed, lattice size parameter design and lattice structure porosity design are carried out to strut parameter;The core structure and peripheral structure of connecting interface are obtained, and the model obtained by modeling is obtained.The mechanical properties of helical gradient lattice structure are improved, the pore connectivity and distribution law are optimized, so that the layer-by-layer increasing of porosity and the continuous transition of double-layer structure interface connection are realized, the material utilization efficiency is improved while guaranteeing the stability of structure, cell migration and bone tissue growth path are effectively guided, and the bone integration ability of scaffold is optimized.