330 results about "Osseointegration" patented technology

The invention discloses a near-infrared light response titanium-based implant as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The near-infrared light response titanium-based implant provided by the invention comprises a porous titanium substrate, the TiO2 nanotube array is formed on the surface of the porous titanium substrate; the first photo-thermal coating layer is formed on the TiO2 nanotube array; the second photo-thermal coating is formed on the first photo-thermal coating; wherein the first photo-thermal coating is a ZIF-8 coating; and the second photo-thermal coating is a carbon nanotube coating. Through the double-layer photo-thermal system design of the ZIF-8 coating, the photo-thermal conversion efficiency is greatly improved, the controllable photo-thermal response capacity, the long-acting antibacterial and anti-tumor capacity and the dynamic osseointegration capacity are achieved, and the excellent osteosarcoma treatment effect is achieved.

The invention relates to the technical field of oral implantation guidance, and provides a digital false tooth mounting and positioning device based on three-dimensional scanning and a method thereof. The method comprises the following steps: scanning the oral cavity of a patient through an oral cavity scanner to generate a three-dimensional oral cavity digital model; generating a virtual implant of the patient and corresponding initial implantation parameters based on the three-dimensional oral cavity digital model through a SegFormer segmentation network; based on historical operation data, initial implantation parameters, bone density, patient attributes and occlusal force parameters, a long sequence prediction network is adopted to predict the position offset and bone resorption degree of the virtual implant after osseointegration through a segmented attention mechanism and a network memory cache mechanism, and optimal implantation parameters are obtained; and pushing a visual dynamic model containing the candidate positioning strategy to the user based on the optimal implantation parameter, driving an oral cavity model printer to obtain an implantation guide plate model and an oral cavity environment model, assisting the user in verifying the installation effect of the candidate positioning strategy, and improving the accuracy of false tooth installation and positioning.

The invention relates to the technical field of medical instruments, and discloses an angle-adjustable artificial hip joint prosthesis structure which comprises a thighbone connecting assembly, an acetabulum connecting assembly and a movable part movably connected between the thighbone connecting assembly and the acetabulum connecting assembly. The thighbone connecting assembly comprises a first connecting unit fixedly connected with the movable part, a thighbone stem detachably connected to the lower end of the first connecting unit, and a connecting screw fixedly connected to the upper end of the thighbone stem and in threaded connection with the first connecting unit. The acetabulum connecting assembly comprises a second connecting unit fixedly connected with the movable part and an acetabulum fixedly connected to the second connecting unit. Stable rotating connection is achieved through the double-shaft moving part, and a traditional easily-abraded spherical surface structure is replaced; the locking assembly is matched to realize personalized angle adjustment and locking; the femoral stem can be detached and replaced, and adaptability is improved; the surface composite coating promotes osseointegration and improves biocompatibility, the overall structure stability is high, adaptability is high, and postoperative recovery is fast.

The invention discloses a multifunctional coating capable of forming a long-term stable endogenous electric field to promote antibiosis, and a preparation method and application thereof, and belongs to the technical field of biological functional modification. According to the coating, through the elaborately designed Ta / Ag heterostructure, long-term stable generation of an endogenous electric field is achieved, the antibacterial performance is enhanced, osseointegration is promoted, and the problem of drug resistance is avoided; the coating does not need external electrical stimulation, so that the operation process is simplified, and the clinical application risk is reduced; due to the Ta material, the osseointegration capacity is improved, and Ag has broad-spectrum and efficient antibacterial performance. The TC4-Ta / Ag group has excellent charge storage capacity and a stable electric field, and the long-term osseointegration effect is remarkably improved; according to the preparation method of the coating, the coating which is stable in structure and not prone to falling off can be obtained, the long-term stable antibacterial performance is kept, the coating has wide application prospects in the field of titanium alloy bone implants, a new solution is provided for orthopedic surgery and implant treatment, and the treatment effect and life quality of patients are improved.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The invention relates to a bone tumor repairing method based on three-dimensional reconstruction and a bionic structure. The method comprises the following steps: acquiring multi-modal medical image data of a bone tumor area of a patient to obtain an initial bone tumor three-dimensional model; generating a three-dimensional dynamic bone defect model for describing a bone tumor area based on the geometric structure of the initial bone tumor three-dimensional model; based on the three-dimensional dynamic bone defect model, generating a bionic implant three-dimensional model meeting bone defects; performing space alignment on the bionic implant three-dimensional model and the three-dimensional dynamic bone defect model to obtain a bone tumor repair model; carrying out restoration stability and osseointegration effect verification on the bone tumor restoration model to obtain a verification result; the verification result is used for indicating dynamic adjustment of the bionic implant three-dimensional model, and a final bone tumor repair three-dimensional model is obtained. By adopting the method, the accuracy, reliability and individuation level of bone tumor treatment can be improved.

The invention provides a novel TPMS porous structure interbody fusion cage, and relates to the technical field of medical materials. The interbody fusion cage is designed by using a porous frame structure with different unit cell sizes and porosities, so that the biocompatibility of the interbody fusion cage is enhanced, the interbody fusion cage has higher mechanical properties, large static compression load and low elastic modulus, the elastic modulus is closer to that of human cortical bones, the stability of an implant in the early stage of osseointegration is improved, and the interbody fusion cage is suitable for being used in the field of osteosynthesis. Under the same porosity, the elastic modulus is lower, and the comprehensive performance is excellent.

A rotary tool configured for high-speed condensing and / or cutting action to enlarge a hole. The tool has a body around which is formed a plurality of flutes. Each flute has a cutting face on one side and a densifying face on the other side. A land between adjacent flutes establishes a substantially margin-less working edge along each cutting face. The working edges are configured to produce osseodensification when the tool is operated in the condensing mode. A transverse valley is formed at the apical end of the body. The valley is a relief in the tip that creates several secondary cut / grind edges that are useful to produce and evenly distribute bone debris. When withdrawing the rotary osteotome from an enlarged hole, a small button of bone debris remains at the bottom of the hole. The button remnant facilitates new bone ingrowth and osseointegration of a subsequently installed anchor.

The invention discloses a bionic heterogeneous composite structure bone implant and a preparation method thereof, and relates to the technical field of medical implants.The bionic heterogeneous composite structure bone implant comprises an inner-layer cross-shaped structure, a middle-layer negative Poisson's ratio structure and an outer-layer honeycomb structure, and the cross-shaped structure, the negative Poisson's ratio structure and the honeycomb structure jointly form a bionic composite structure; and immersing the bionic composite structure subjected to double-network crosslinking into a drug-containing solution for post-treatment and drug loading to obtain the bionic heterogeneous composite structure. According to the invention, bionic adaptation and intelligent optimization of mechanical properties are realized, and the stress shielding problem is solved; according to the invention, osseointegration and vascularization processes are obviously accelerated and enhanced, and leap-type improvement of biological activity is realized; a novel intelligent treatment mode based on in-vivo microenvironment response is developed, and on-demand and accurate drug delivery is achieved.

The present invention concerns a device (1) for restoring the integrity of the cranial bones, particularly of the non-resorbable type, comprising a plate body (3) in turn comprising a central body (5) and at least one peripheral portion (71), wherein said at least one peripheral portion (71) comprises fastening means (72) for fastening the device itself to the cranial bone (100), and wherein said cranial fixation device (1) comprises, at said central body (5), at least one insertion portion (50) protruding in a direction substantially orthogonal to said plate body (3) and which is configured to be inserted within a hole (102), drilled in the skull (100) of a patient, wherein said insertion portion (50) comprises a trabecular structure (51), suitable for stimulating bone regrowth and osseointegration of the device itself.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

The present disclosure includes fixation devices, such as an orthopedic screw or implant, that comprises one or more porous elements or fenestrations to aid in osteo-integration of the fixation device. The fixation device may be additively manufactured using biocompatible materials such that the solid and porous aspects of the screw are fused together into a single construct. In yet another aspect, the fixation device comprises at least a portion or section incorporating a porous structure, which enables bony ingrowth through the porous section / portion of the screw, and thereby facilitates biocompatibility and improve mechanical characteristics. Methods for using the fixation device are also described herein.

An orthopedic implant includes a main body, which has a downward tapered configuration formed of a plurality of steps of different diametrical sizes arranged along a drilling axis, each of the steps includes a cylindrical and a conical section, and the conical section of the lowest and diametrically smallest step is downward tapered into an apex; an external thread, which is externally formed on the main body to cover all the cylindrical sections but not the conical sections; a plurality of lateral cutting flutes, which are formed on the external thread into the main body and extended from the apex to the diametrically largest step with a spacing distance left between upper ends of the lateral cutting flutes and a top of the largest step. The orthopedic implant can be independently driven into a bone without the need of bone cutting using drill bits in advance and enables good osseointegration.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

The utility model relates to the technical field of implants, and provides a stabilizing device for immediate auxiliary retention of an implant in order to solve the problems of displacement and infection existing in implant repair, the stabilizing device comprises a device body, the device body comprises a shielding structure, an embedding structure, a repair structure and a connecting structure, the repair structure is a columnar structure, and the connecting structure is connected with the shielding structure. The shielding structure is formed by outwards extending from the top of the self-repairing structure and concaving inwards, the edge of the shielding structure forms an embedded structure in a sharp corner state, and the connecting structure is arranged at the bottom of the device body, so that external force interference of the healing abutment on the implant is reduced, a more stable environment is provided for osseointegration, osteogenesis around the implant is facilitated, and the healing effect of the implant is improved. Operation times are reduced, operation wounds are reduced, and good development prospects are achieved.

The invention relates to a 3D printing porous metal-ceramic assembled composite implant as well as a preparation method and application thereof. The 3D printing porous metal-ceramic assembled composite implant comprises a porous metal-ceramic implant body formed by compounding a 3D printing integrated porous metal module and a 3D printing integrated porous ceramic module, the porous metal-ceramic implant body and the net-shaped metal protection body are arranged on the periphery of the porous metal-ceramic implant body in a wrapping mode, and the assembled composite implant can be accurately matched with the appearance and the combination surface of bone tissue of a defect part. The composite implant disclosed by the invention has osteogenesis environment regulation and control functionalization, and can achieve the effects of immediately recovering the movement function of defective bone tissue, improving the tissue microenvironment of a bone defect part, accelerating new bone regeneration and guiding new bone to grow towards the interior of the porous metal implant, so that rapid osseointegration of a bone / metal implant interface is realized; and the long-term treatment effect of 3D printing porous metal implant / autologous bone fusion type repair after ceramic degradation is achieved.

The invention relates to a time sequence degradable orthopedic implant material which comprises a base material and a biodegradable coating formed on the surface of the base material, the surface of the base material is provided with a nanocone array microstructure, the biodegradable coating takes a biodegradable polymer as a matrix and loads a metal element for promoting bone repair, and the metal element is a metal element for promoting bone repair. And the surface of the biodegradable coating is also connected with an anti-inflammatory active factor. According to the invention, grafted anti-inflammatory active factors are matched with the biodegradable coating loaded with metal elements for promoting bone repair, and the sequential active regulation and control of the biological effect of the micro-morphology on the surface of the base material cope with effector cells in different repair stages; the time sequence regulation and control on the macrophage inflammation phenotype and bone marrow mesenchymal stem cell osteogenic differentiation in different stages of bone repair are realized, so that each stage of bone tissue repair is matched, and bone repair and osseointegration are promoted.

The invention relates to a prosthesis material, a nose prosthesis containing the same and a preparation method. The prosthesis material comprises 20-90 parts of a degradable high polymer material and 10-80 parts of an inorganic material, the degradable high polymer material comprises any one or a combination of at least two of polycaprolactone, polylactic acid, polyurethane or polyether-ether-ketone; the inorganic material comprises tricalcium phosphate and / or hydroxyapatite. By designing and preparing the composite wire rod in a specific proportion, the flexibility and ductility of the prosthesis are improved, and enough mechanical strength and ideal osseointegration capability can be provided; and in combination with a personalized design process, precise customization and efficient manufacturing of the nose prosthesis are realized.

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.

A cage type support for bone grafting capable of achieving heat balance comprises a support shell and a base, and a multipurpose cavity is formed in the base. The inner cavity of the bracket shell is communicated with the multi-purpose chamber through a heat convection pipe group; the multipurpose cavity is configured to be a heat dissipation end communicated with the inner cavity, and heat balance of the inner cavity and the multipurpose cavity is achieved through a heat convection pipe set communicated between the multipurpose cavity and the inner cavity; a stable supporting foundation is provided, the osseointegration process is promoted, heat balance of the whole stent is achieved, the internal temperature of the femoral head is properly increased, local blood circulation of the femoral head is accelerated, cell activity is enhanced, metabolism is accelerated, proliferation and differentiation of related cells such as bone cells are promoted, angiogenesis and bone repair are promoted, and gas exchange is facilitated. The implant can be used for promoting the discharge of hydrops and pneumatosis, continuously releasing intraosseous pressure and providing a storage space and path for therapeutic drugs and / or nutritional ingredients, and the implant realizes multi-system collaboration and promotes overall rehabilitation.

An implantation kit including a rotational osteotome and an implant is disclosed. The rotational osteotome includes a plurality of steps of different diametrical sizes, a tip, and at least one flute; and every step includes an annular bottom bevel to provide a cutting edge and recessed section. The implant includes a body having a cylindrical head section and a conical section provided with an external thread and a plurality of spiral flutes. The conical section has a downward tapered profile correspondingly aligned with the recessed sections. The cylindrical head section has a straight cylindrical profile matching that of the step having the largest diametrical size. With the above arrangements, an implant hole on a bone can be formed in only one drilling with one single osteotome for fixedly holding the implant therein. Therefore, the time needed for dental and orthopedic surgeries is largely shortened while better osseointegration can be achieved.

Disclosed is a method for treating a polyaryletherketone (PAEK) material to improve osseointegration properties of the PAEK material. The method includes: subjecting the PAEK material to a sulfonation process comprising contacting the PAEK material with sulfuric acid at a temperature and for a time sufficient to cause sulfonation of at least a portion of aryl groups of the PAEK material; following sulfonation and prior to exposing the PAEK material to water, subjecting the PAEK material to a physical cleaning process to remove at least a portion of excess sulfuric acid from the PAEK material; and subjecting the PAEK material to a hydrothermal process comprising contacting the PAEK material with water at a temperature and for a time sufficient to cause substantial de-sulfonation of the PAEK material. The resulting PAEK material includes porous surfaces that beneficially promote osseointegration when used in an implantable device.

The invention provides an artificial prosthesis assembly for an ankle joint replacement operation, and belongs to the technical field of ankle joint prostheses. Comprising a talus arc plate, an arc-shaped guide rail is installed at the top of the talus arc plate, rivets are installed in the talus arc plate, a joint soft plate is connected to the top of the arc-shaped guide rail in a sliding mode, and a tibia installation plate is installed above the joint soft plate; and a rivet fixing assembly is mounted at the top of the tibia mounting plate. By arranging the elastic adjusting assembly and the sliding lubricating assembly, the contact area with bone tissue can be remarkably increased, the initial stability of the prosthesis is enhanced, the separation risk of the prosthesis is reduced, and the elastic relaxation degree of the prosthesis is adjusted and controlled, so that the modulus of the prosthesis is dynamically matched with the bone elasticity of a patient, and the bone interface stress concentration risk of the prosthesis is reduced; meanwhile, the movement resistance of the prosthesis is reduced through ball lubrication, material fatigue and loss caused by dry friction between the prostheses are avoided, and the service life of the prosthesis is prolonged.

An implant system has an acetabular cup with an interior bearing surface with a central bearing zone that is smooth and devoid of holes or indentations. The cup also has a peripheral bearing zone that contains insertion tool engagement holes. The engagement holes are only present in the peripheral zone and have specific shapes and dimensions. The system includes an insertion tool with retractable interlocks that fit within the engagement holes to position the cup during implantation. The central bearing zone bears the main forces during articulation, while the peripheral zone withstands minor forces. The location of the engagement holes has a negligible effect on the cup's performance. The cup can be made of ceramic and may have a coated exterior surface for osseointegration.

The invention discloses an anti-inflammatory osteogenesis-promoting titanium-based implant which comprises a titanium base material, a TiO2 nanotube array layer is constructed on the surface of the titanium substrate in situ; iL-4 is loaded in the TiO2 nanotube array layer, and the surface of the TiO2 nanotube array layer is grafted with a gate molecule mPEG2000-PLGLAL-(PEG4)-C. The invention further discloses a preparation method of the TiO2 nanotube array. The anti-inflammatory osteogenesis-promoting titanium-based implant can respond to MMP concentration change of a surrounding microenvironment so as to regulate and control the release rate of IL-4, in the early stage of bone healing, IL-4 is slowly released, M1 macrophages are dominant, a short and moderate inflammatory reaction is kept, along with response to MMP in the microenvironment, IL-4 is rapidly released, M1 polarization is inhibited, and the osteogenesis-promoting titanium-based implant has the advantages of being good in anti-inflammatory effect and capable of promoting osteogenesis. And inflammation is eliminated in time, M2 polarization is promoted, wound repair is accelerated, osseointegration is further promoted, dynamic regulation of immune response is realized, and a new strategy is provided for promoting bone tissue regeneration through immune regulation.

Methods for accommodating dental implants in treatment planning. Methods may include generating a treatment plan to treat a dentition using a series of dental appliances, where a position of a digital implant in a digital dental model is identified. At least one dental appliance of the series of dental appliances may be created, where the at least one dental appliance may be shaped to implement at least one stage of the treatment plan and include an offset portion that is shaped to provide a space between the offset portion and an actual implant to avoid impingement of the at least one dental appliance on the actual implant and allows for osseointegration of the actual implant.

The invention discloses an engineering construction composite artificial bone based on architectural engineering and a manufacturing method thereof.The engineering construction composite artificial bone comprises a bioactive material and a mechanical supporting scaffold, the bioactive material serves as a main body, the mechanical supporting scaffold is contained in the bioactive material, and the bioactive material and the mechanical supporting scaffold are tightly combined to form an artificial bone tissue complex; the mechanical support bracket can provide mechanical support for the artificial bone tissue complex so as to meet the load requirement in the bone repair process. The artificial bone tissue complex can further achieve one or more functions through surface modification and / or a carrying structure used for carrying a bone growth promoting material release system and / or a drug release system arranged in the artificial bone tissue complex so as to meet the clinical requirements of anti-inflammation, anti-infection, anti-tumor, anti-osteoporosis, bone integration promotion and the like. The bone integration performance and mechanical performance of the material are considered, and a new scheme is provided for large-area bone defect repair, bone structure filling and supporting and parts needing long-term load bearing.

The invention discloses a coating deposition process for an implant, and relates to the technical field of implant coating preparation, and the deposition process comprises the following steps: S1, base material pretreatment: placing a base material in a deionized water mixed solution for ultrasonic cleaning, adopting low-temperature plasma purification treatment, utilizing high-energy particles of plasma to bombard the base material, and using the high-energy particles of the plasma to bombard the base material; the preparation method comprises the following steps: removing surface and internal impurities, introducing active groups, forming a nanoscale rough interface with the surface roughness Ra of 50-200nm on the surface of a base material through a chemical etching process and femtosecond laser etching synergistic process, and carrying out vacuum drying on the base material; s2, metal gasification: placing a metal tantalum raw material in an upstream heating zone of the reaction chamber; the chemical vapor deposition (CVD) technology is adopted, osseointegration can be promoted, the infection risk can be reduced, the method is suitable for porous implantation instruments of the orthopedics department, the dental department and the like, the obtained coating technology is compatible with a complex base material structure, the clinical curative effect and the life quality of a patient are improved, large-scale production is supported, and development of a new material industry chain is promoted.

A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and / or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and / or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

The invention discloses a preparation method of an active coating of a surgical titanium alloy fusion cage. The preparation method comprises the following steps: S1, preparing a titanium alloy fusion cage with a porous structure through 3D printing; s2, constructing a polydopamine coating on the surface of the titanium alloy fusion cage; s3, preparing a calcium phosphorus deposition solution, and performing hydroxyapatite mineralization on the polydopamine coating; and S4, grafting TBMP2 protein on the surface of the hydroxyapatite mineralized coating to complete the preparation of the titanium alloy fusion cage active coating. The problems that an existing titanium alloy fusion cage is poor in biological inertness and osseointegration performance and has many side effects in BMP2 application are solved, and the titanium alloy fusion cage can adapt to personalized implantation requirements.