49 results about "Periosteum" patented technology

The invention relates to an artificial periosteum suitable for a complex bone surface. The artificial periosteum is an integrated single-layer membrane. The artificial periosteum is provided with an anti-adhesion area, a directional pore channel structure area and a bone contact area which are sequentially distributed in the thickness direction. The directional pore channels are sequentially filled with composite hydrogel for filling bone surface pores and promoting bone repair and bonding gel for bonding bone surfaces in the extending direction of the directional pore channels; an expanding agent and prestretching memory polymer fibers are dispersed in a matrix of the artificial periosteum; the expanding agent is enriched in the matrix of the directional pore channel structure area and the bone contact area and is used for driving the composite hydrogel to leave the directional pore channel so as to seal bone surface gaps or cracks; and the pre-stretched memory polymer fibers are enriched in the matrix of the anti-adhesion area and are used for limiting the expansion direction of the expanding agent. The artificial periosteum can solve the technical problems that in the prior art, the attaching effect of the artificial periosteum on the complex bone surface is poor, and the long-term reliability is poor.

The application discloses a path planning method for subcutaneous deep layer injection of a mandible, which comprises the following steps: determining a target region of a subcutaneous deep layer which needs to be filled or improved in contour based on three-dimensional anatomical data of a mandible; the subcutaneous deep layer refers to a loose connective tissue gap between a subcutaneous fat layer and an upper periosteum layer; planning a main path which is substantially parallel to a baseline of a lower edge of the mandible or substantially coincides with a preset mandible contour line in the target region; the main path is located in the subcutaneous deep layer; planning a plurality of branch injection paths based on the main path; the starting points of the branch injection paths are distributed at intervals along the main path and extend alternately to the outside of both sides of the main path; and all the paths form a wheat ear-shaped topological structure with the main path as a central axis and the branch injection paths extending to both sides. The method effectively avoids excessive concentration of fillers in any dimension, thereby significantly reducing the swelling degree of local tissues caused by pressure concentration and being beneficial to shortening the recovery time.

The invention discloses an operation method for splitting an oral implant bone, which comprises the following steps of: preparing an ultrathin bone sheet of which the buccal side is less than 1mm, reserving physiological connection between periosteum and the bone sheet, and constructing a periosteum bone flap. The periosteum flap is of a natural barrier membrane structure, and integrates the function of a bone sheet rigid support and the semi-permeable membrane characteristic of the periosteum. The buccal ultrathin bone sheet is connected with the basal bone, is a rigid support structure, supports an osteogenesis space, and can provide bone marrow stroma cells to participate in bone defect repair. Physiological attachment of periosteum is not only a blood supply source of an inner side bone sheet, but also exerts the characteristics of a semi-permeable membrane, replaces an artificial barrier membrane to stop fiber tissue from growing in, and follows the PASS principle of the GBR technology, so that the operation risk is reduced, the use of the artificial barrier membrane is reduced, the adaptation disease of bone splitting is widened, the absorption of buccal side bones is reduced, and the bone splitting effect is improved. And the clinical effect of bone defect repair is improved.

The application discloses a jaw bone defect negative pressure repair body with a flushing function and a preserved periosteum, which comprises a base body, the base body is a titanium alloy net structure formed by 3D printing, two ends of the base body are adapted to be attached to bone broken ends, and an outer surface of the base body is adapted to be contacted with jaw bone periosteum, the base body is internally provided with a negative pressure suction pipeline penetrating through the base body, an outer pipe opening of the negative pressure suction pipeline is connectable to a negative pressure suction device, a pipe wall of the negative pressure suction pipeline is distributed with through holes formed by the titanium alloy net structure, and a reserved flushing pipeline is arranged around an outer periphery of the negative pressure suction pipeline, and the reserved flushing pipeline is distributed with flushing holes around the outer periphery. The repair body has the following functions: promoting growth and differentiation of osteoblasts on the surface of the bone broken ends and the periosteum, and promoting new bone formation; and being capable of discharging tissue exudates and the like out of the body.

The invention relates to the technical field of periosteal repair, and particularly discloses a suture anchor for periosteal cartilage defect repair and a using method thereof.The suture anchor comprises at least two anchor bodies, the head of each anchor body is a pointed cone part, and a suture blind hole is formed in the tail of each anchor body; at least one group of threading rods which are arranged at intervals with the bottoms of the threading blind holes are arranged in the threading blind holes; the at least one tail line penetrates through the threading blind hole of the anchor main body; and the anchor main body and the tail line are made of biocompatible materials. After the tail line is tightened, irreversible fixation is achieved through an automatic locking structure, postoperative tail line loosening or periosteum displacement is avoided, and the cartilage regeneration effect is improved.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.

FIELD: otorhinolaryngology.SUBSTANCE: under endotracheal anesthesia, an endoscope equipped with optics and an instrument for removing pathological contents of the maxillary sinus are inserted into the nasal passage. The inferior nasal concha is displaced medially using a raspatory. Then, stepping back from the edge of the piriform opening by 1.5–2.0 cm in the caudal direction, a mucoperiosteal flap of the lateral wall is separated in the lower nasal passage. The mucoperiosteal flap is displaced posteriorly, exposing the bone skeleton in the projection of the inferomedial angle of the maxillary sinus. Next, using a cold plasma coblator, in ablation mode, the mucous surface of the bone skeleton is evaporated for 2–3 seconds, followed by coagulation of small vessels. Then, a bone valve measuring 10–15 mm is formed from the exposed bone skeleton. The bony valve is retracted in the caudal direction, forming an antrostomy. A 70-degree endoscope is inserted through the formed antrostomy and the pathological contents of the sinus are visualized. In this case, if the cyst is visualized with a coblator in ablation mode, the cyst is evaporated along with its contents, and the remaining cyst is captured and removed. If a polyp is visualized, the polyp stalk is first evaporated, and then the remaining part of the polyp is removed. If a foreign body is visualized, it is removed with forceps. In this case, if the foreign body is encapsulated or located in the thickness of the mucosa, a coblator in ablation mode evaporates part of the mucosa until the foreign body is exposed, and then removed. Next, the sinus cavity is washed with saline solution. The antrostomy is closed with a bone flap. The formed mucoperiosteal flap is placed back in its original place.EFFECT: method allows for endoscopic endonasal removal of pathological contents from the maxillary sinuses with a minimal risk of cyst / polyp recurrence and postoperative complications, reduced blood loss during surgery, shortened surgical time, postoperative rehabilitation periods, and temporary disability.3 cl, 3 ex

The utility model belongs to the field of medical instruments suitable for orthopedic surgery, and particularly relates to a periosteum distraction device for a skull, which comprises a strip-shaped distraction plate bent in an arc shape, a sleeve and a distraction nail provided with external threads, one end of the distraction plate is provided with a combination hole penetrating through the upper surface and the lower surface, and the combination hole is composed of a groove and a threaded hole; a boss matched with the groove in an inserted mode is arranged on the end face of one end of the sleeve, and the sleeve is inserted into the groove in the convex face direction of the stretching plate. The distraction nail penetrates through the sleeve and then is in threaded connection with the distraction plate, the nail tail of the distraction nail extends to the outside of the sleeve, and the nail head of the distraction nail extends to the concave face side of the distraction plate and is configured to make contact with the bone surface. According to the distraction device, the distraction plate can be driven to rotate integrally by rotating the sleeve through the inserting and matching structure of the groove and the sleeve, flexible adjustment of the position of the distraction plate is achieved, periosteum can be stimulated in a targeted mode, and therefore regeneration of subperiosteal blood vessels can be promoted.

The utility model relates to the technical field of orthopedic surgical instruments, in particular to a pair of minimally invasive osteotomy guide forceps, which comprises a first forceps handle and a second forceps handle, the guiding clamp is reasonable and compact in structure, in the osteotomy process, only periosteum at the position to be subjected to osteotomy needs to be stripped, after the guiding clamp is closed, the left portion of the upper bendable clamp head and the left portion of the lower bendable clamp head can surround the periphery of a bone, the upper guiding groove and the lower guiding groove are synchronously combined, and at the moment, a fretsaw penetrates through the upper guiding groove and the lower guiding groove to conduct osteotomy. The fretsaws can be separated from the corresponding guide grooves to cut off the skeleton by alternately drawing the two ends of the fretsaws; during an operation, the fretsaw is protected by the upper bendable clamp head and the lower bendable clamp head, so that an operative incision cannot be expanded, peripheral nerves, blood vessels and soft tissues of bones can be effectively protected, unnecessary damage to surrounding tissues is avoided, the operation time is greatly shortened, the possibility of postoperative complications is reduced, and the postoperative rehabilitation time of a patient is shortened.

The utility model discloses an auditory ossicle prosthesis capable of rotating in two dimensions and adjusting and locking the length. The auditory ossicle prosthesis comprises a first fixing element connected to a periosteum and a second fixing element connected to a stapes plate, the first fixing element is installed at the head end of the first rod part, the tail end of the first rod part is installed at the head end of the second rod part in a pitching rotating mode, and the first rod part can be locked on the second rod part after angle adjustment is completed. The tail end of the second rod part can be horizontally and rotatably mounted in the second fixing element, the second rod part after angle adjustment can be locked on the second fixing element, and the length of the second rod part can be adjusted in the axial direction of the second fixing element under the action of external force. Two-dimensional rotation adjustment of the ossicle prosthesis, locking after two-dimensional rotation adjustment and length adjustment can be achieved.

The utility model discloses an intramedullary needle for treating fracture and convenient to hold, which is provided with a treatment section and a holding section for operating and holding, and a positioning structure for holding and positioning is further arranged on the holding section. The intramedullary needle conforms to tubular bone biological fixation, the treatment section can be effectively prevented from rotating in the surgical treatment operation process through the holding section, the penetration depth and path of the treatment section can be further accurately controlled, the treatment accuracy is improved, and the treatment duration is shortened. When the intramedullary needle is used in the treatment process of metacarpal bone fracture, further damage to fracture local hematoma and periosteum can be avoided through closed reduction, blood supply of sclerotin is protected, and fracture healing is facilitated. The intramedullary needle is small in trauma, small in wound scar and beneficial to attractiveness; intramedullary fixation retains the minimally invasive characteristic of kirschner wire fixation, and the fixing effect is more stable and lasting than that of a kirschner wire, and the articular surface is not damaged.

A memory alloy periosteal traction plate is provided, including a plate body and screws. A work surface, a proximal installation end, and a distal installation end are formed on the plate body. The work surface fits a surface of a curved long bone, and extends in a length direction of the long bone. The proximal installation end is located at one end, close to a proximal end of the long bone, of the plate body, and the distal installation end is located at one end, close to a distal end of the long bone, of the plate body. Both the proximal installation end and the distal installation end are firmly connected to the long bone through screws by means of multiple fixing points, the plate body can gradually transition from a bending state to a straight state by means of deformation.

The application discloses a kind of biomimetic composite scaffold with periosteum-cortical bone-cancellous bone structure and its preparation method and application.The scaffold is assembled by independent periosteum biomimetic scaffold module and independent bone trunk biomimetic module.The periosteum biomimetic scaffold module is cylindrical tube structure hydrogel, loaded with zinc silicate particles and periosteum related cells, with the biological functions of promoting cartilage differentiation, secreting nerve and vascular factors and synthesizing periosteum matrix proteins.The bone trunk biomimetic scaffold module is cylindrical bioceramic, with multiple vertical pipes embedded in the dense layer of outer wall to simulate cortical bone, and with staggered structure inside to simulate cancellous bone.Animal experiments show that the biomimetic composite scaffold can effectively promote the integrated regeneration of bone trunk and periosteum in rabbit radial critical size defect model.Therefore, the application provides a new solution for the biomimetic design and regeneration repair of bone tissue engineering.

The utility model discloses a scalp scar incision knife for the edge of a bone window, which is divided into an L type and a T type, and each type is divided into two edging directions, namely a clockwise edging direction and an anticlockwise edging direction; the T-shaped scalpel comprises a scalpel handle, a first blade or a second blade, the scalp of a surgical part of a patient is transversely and longitudinally cut open at the same time through the additional arrangement of the first blade or the second blade, and the convenience of medical staff in surgical use is improved; a downward edged blade and an upward edged blade are arranged on the blade side, the skull side blade is edged downwards, periosteum and skull of a patient are separated, the downward blade can prevent the scalp from being too thin, and it is guaranteed that the blade is tightly attached to the surface of the skull to be pushed. The blade in the bone window is edged upwards, so that damage to meninx and brain tissue of a patient caused by the blade can be avoided, the use safety is improved, the situation that medical staff frequently replace tools in the operation process is avoided, and the use difficulty of the medical staff is reduced.

1. Name of the product in this design: Gingival retractor. 2. Purpose of this design: To retract the gingival tissue or periosteum during oral cavity repair. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention discloses a bone-periosteum bionic stent for vascularized bone regeneration and a preparation method of the bone-periosteum bionic stent, and belongs to the technical field of bone repair. The stent comprises a bone bionic stent and a bionic periosteum, the bone bionic scaffold is of a hierarchical pore structure and is formed by compounding polycaprolactone, silk fibroin and beta-tricalcium phosphate through fused deposition 3D printing, and the surface of the bone bionic scaffold is subjected to alkali treatment so as to improve hydrophilicity and osteogenic activity; the bionic periosteum is printed on the surface of the bone bionic scaffold through a near-field direct writing technology and is composed of polycaprolactone, mineralized collagen and magnesium ions, and the mineralized collagen is distributed in the bionic periosteum in a gradient mode. Through integrated bionic design, structures and functions of natural bones and periosteum are simulated; the bone bionic support plays a role in mechanical support and bone formation promotion; the bionic periosteum rapidly releases magnesium ions in the early stage of degradation, and early vascularization is promoted; along with degradation, continuously released collagen induces mineralization of a collagen matrix in the later period; the stent has good cell compatibility and capability of promoting osteogenic differentiation and blood vessel formation.

In one or more embodiments orthopaedic implants may be provided. The implants may include an expansile structure which may allow for increased contact between an endosteal or periosteal surface for initial fixation and further allow for bone in-growth and / or on-growth. In some embodiments the expansile structure may be made of, for example a NiTiNol structure, which may further be programmed for expansion at body temperatures. In some embodiments the interstices of the expansile structure may further be filled with a shape memory polymer and / or other elastic material which may also be programmed for expansion at body temperatures.

The invention belongs to the field of biological materials and tissue engineering, and provides a preparation method and application of a multistage bionic periosteum capable of regulating and controlling an osteogenesis microenvironment, oxidized xyloglucan is dissolved in water, BMP2 is added for mixing reaction, and an OXG-BMP2 solution is obtained; the preparation method comprises the following steps: adding an OXG-BMP2 solution into dichloromethane, dropwise adding an emulsifier, and stirring to obtain an emulsion containing OXG-BMP2 microparticles; adding L-polylactic acid and N, N-dimethylformamide into the emulsion containing the OXG-BMP2 microparticles, and obtaining a core-shell structure spun yarn by using an electrostatic spinning technology; the method comprises the following steps: mixing TA-Ce nano-enzyme into I-type rat tail collagen, uniformly mixing, dropwise adding into core-shell structure spinning, and incubating to complete self-assembly of the bionic periosteum, thereby obtaining the multi-stage bionic periosteum capable of regulating and controlling the osteogenesis microenvironment. The multi-stage bionic periosteum can regulate and control the osteogenesis microenvironment and sequentially promote osteogenesis, and has great application prospects in the aspects of bone injury repair and the like.

In a dental implant surgery, bone grafting is needed due to insufficient bone mass, and periosteum tension reduction is needed during bone grafting, so that the minimally invasive periosteum tension reduction device is an instrument for periosteum minimally invasive tension reduction during dental implant, and aims to reduce the pain of a patient during periosteum tension reduction during implant and improve the operation convenience of a doctor. In the current oral implant surgery, the existing implant periosteum distension reduction instrument is only provided with a surgical blade clinically at present, and a doctor needs to add a vertical incision in the periosteum distension reduction process, so that the pain of a patient is greatly increased, the operation time of the doctor is greatly prolonged, and the operation difficulty of the doctor is also increased. According to the minimally invasive periosteum tension reducing instrument for oral implantation, vertical incisions of an implantation area are reduced, the direction and the movement track of a traditional scalpel are changed, the minimally invasive purpose is achieved, and the consequences that the vertical incisions of gingival mucosa are increased by the traditional scalpel and the soft tissue of a patient is excessively injured due to too deep cutting of the traditional scalpel are not brought to a doctor; compared with the prior art, the device has the advantages of being minimally invasive, reducing the pain of a patient, shortening the operation time, facilitating operation of a doctor, improving the operation efficiency, removing a vertical incision during periosteum tension reduction, reducing postoperative suture wound cracking, preventing the risk of infection caused by bone meal exposure, providing an effective solution for complex oral implant cases, and having a wide application prospect. And the treatment experience and satisfaction degree of the patient are improved.

The utility model belongs to the medical instrument field suitable for orthopedics operation, concretely relates to a multipurpose periosteal distraction device, at least includes: the periosteal distraction board is the strip board that presents the arc shape bending in the length direction, one end of periosteal distraction board is provided with locking hole, the bone needle has the needle head of inserting on the skeleton in one end, is equipped with the limit snap ring in the other end, the distraction nail is equipped with the through cavity that penetrates the distraction nail along the length direction inside, the distraction nail is divided into the nail head and the threaded rod that is screwed with locking hole, the distraction nail is screwed with periosteal distraction board, the bone needle is inserted in the through cavity, the limit snap ring is located nail head side, the needle head protrudes distraction nail outside. The utility model's periosteal distraction device can solve the technical defects of the periosteal distraction board of prior art because of stripping incision bilateral periosteum and big trauma, poor applicability when skull periosteum is distracted and bone needle inserts too deep.

In one or more embodiments orthopaedic implants may be provided. The implants may include an expansile structure which may allow for increased contact between an endosteal or periosteal surface for initial fixation and further allow for bone in-growth and / or on-growth. In some embodiments the expansile structure may be made of, for example a NiTiNol structure, which may further be programmed for expansion at body temperatures. In some embodiments the interstices of the expansile structure may further be filled with a shape memory polymer and / or other elastic material which may also be programmed for expansion at body temperatures.

The invention discloses a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and setting bone, which is composed of an internal medicine and an external medicine, the internal medicine comprises radix angelicae lateralis preparata, radix paeoniae rubra, peach kernel, safflower, ground beetle, native copper, pseudo-ginseng, rheum officinale, dragon's blood, catechu, teasel root, rhizoma drynariae, cortex albiziae, rhizoma bletillae, frankincense and myrrh; and the external application medicine comprises radix angelicae lateralis preparata, radix paeoniae rubra, notopterygium root, radix angelicae pubescentis, frankincense, myrrh, dragon's blood, pseudo-ginseng, borneol, sesame oil, camphor and lead. The composition is composed of an internal medicine and an external medicine, the external medicine can promote blood circulation to remove blood stasis and relieve swelling and pain for swollen skin at the fracture position, and the internal medicine can promote blood circulation, relieve pain, promote bone marrow production and stimulate periosteum growth, so that the healing speed of the fracture and the bone fracture position is increased. The traditional Chinese medicine composition not only can effectively relieve pain and burning feeling of the cortex of a bone trauma of a patient, but also can promote rapid healing of the bone trauma and shorten the braking time of the bone trauma.

The present application relates to a kind of methods for the biomimetic construction of periosteum-like tissue, comprising the step of implanting active substance and / or cell-loaded biomaterials into animals or humans to develop periosteum-like tissue.The constructed periosteum-like tissue has a typical fibrous structure, contains abundant periosteum-derived stem cells and functional blood vessels, can repair critical size bone defects, and is expected to be applied in the clinical treatment of severe bone / cartilage defects, or weak regeneration in elderly patients, etc.

The application provides a periosteum distraction device, which comprises a distraction plate and a support device, the support device comprises a first degradable layer arranged outside, a second degradable layer arranged in the first degradable layer in a radial direction, a support rod arranged in the middle of the second degradable layer, and a through channel reserved in the first degradable layer in an axial direction; the first degradable layer, the second degradable layer and the distraction plate are all made of degradable materials; the support device has a first end connected with the distraction plate and an opposite second end, the first degradable layer and the second degradable layer are configured to have a gradually slower degradation rate from the first end to the second end, and the degradation rate of the first degradable layer is slower than that of the second degradable layer; the distraction plate has a shape memory traction member, and the shape memory traction member passes through the through channel. The periosteum distraction device provided by the application can realize automatic distraction, has precise distraction degree, and does not need to take out the distraction plate after recovery, so that the patient is free from secondary injury.

The invention discloses an artificial periosteum and a preparation method thereof. The preparation method comprises the following steps: performing directional freeze drying on a first solution and a second solution containing mineralized collagen to respectively form a first porous layer facing a bone surface side and a second porous layer facing a soft tissue side; forming a composite scaffold layer between the first porous layer and the second porous layer by using a composite material solution of a biodegradable high polymer material and a bioactive material; any one of the first solution, the second solution and the composite material solution is firstly placed in a mold to be formed; the pore sizes of the first porous layer and the second porous layer are gradually reduced from the bone surface side to the soft tissue side; compared with a second porous layer, the first porous layer formed by directional freeze drying has higher pre-freezing temperature and lower cooling rate, cooling amplitude, vacuum degree, heating rate and sublimation rate. Through a parameter control mode of a directional freeze-drying process, a bionic structure of aperture difference and in-layer gradient aperture distribution is realized on the premise of not changing a material system.

The periosteum distraction device comprises a distraction plate and a supporting device, the supporting device comprises a first degradation layer arranged outside, a second degradation layer arranged in the first degradation layer in the radial direction and a supporting rod arranged in the middle of the second degradation layer, and a penetrating channel is reserved in the first degradation layer in the axial direction; the first degradation layer, the second degradation layer and the stretching plate are all made of degradable materials; the supporting device is provided with a first end connected with the distraction plate and a second end opposite to the first end, the first degradation layer and the second degradation layer are configured in the mode that the degradation rate is gradually decreased from the first end to the second end, and the degradation rate of the first degradation layer is lower than that of the second degradation layer; a shape memory traction piece is arranged in the stretching plate and penetrates out of the penetrating channel. According to the periosteum distraction device, automatic distraction can be achieved, the distraction degree is accurate, the distraction plate does not need to be taken out after healing, and a patient is prevented from secondary injury.

The invention relates to the technical field of medical treatment, in particular to a pressure-adjustable anti-infection periosteum distraction sac device which comprises a distraction sac, a catheter and an automatic liquid injection system. Wherein a cavity is formed in the distraction liquid bag; the catheter comprises an inner catheter body and an outer catheter body. The inner catheter is internally provided with a first catheter cavity, the inner catheter is sleeved with the outer catheter, the inner side wall of the outer catheter and the outer side wall of the inner catheter are spaced to form a second catheter cavity, and the far end of the inner catheter sequentially penetrates through the near-end side wall of the distraction liquid bag and the far-end side wall of the distraction liquid bag and is communicated with the external environment. The far end of the outer catheter is fixedly arranged in the cavity, a first through hole is formed in the side wall of the far end of the outer catheter, and the second catheter cavity is communicated with the cavity through the first through hole; a medical worker can master the condition of a patient at any time through the system, intelligent medical management is achieved, the convenience and efficiency of postoperative nursing are improved, and the medical experience of the patient is improved.

The utility model discloses a kind of absorbable rib fixation nails, made of high molecular absorbable material integrated, including shank part and the clamping portion of both ends of shank part, clamping portion is equipped with bifurcation structure with opening towards non-connection shank part one end, at least one branch outside of bifurcation structure is equipped with inverted tooth structure, inverted tooth structure end is conical or triangular, the width of bifurcation structure is greater than the width of shank part.The utility model can be made into nail body by absorbable material, clamping portion end bifurcation, inverted tooth structure can be fixed after being expanded in marrow cavity and increasing friction, wide conical end is easily placed into marrow cavity and can play anti-rotation, anti-removal effect, fixed firm and not easy to displace, without suture reinforcement to prevent affecting periosteal blood supply and nerve compression, after fracture healing, fixation nail can be degraded and absorbed, without secondary operation removal, after absorption, chest CT, MRI examination has no influence, more promotional, can better improve the user's use experience.

The invention relates to an artificial periosteum comprising a functionalized collagen-containing membrane and a drug- carrier mixture, wherein the drug-carrier mixture comprises at least one therapeutic agent and a calcium-containing carrier mixture. The invention also relates to use of the artificial periosteum for repairing bone.