438 results about "Muscle tissue" patented technology

The invention relates to a skin tissue layering evaluation method, device and equipment, a medium and a program product. The method comprises the following steps: acquiring an original gray-scale ultrasonic image of skin tissue layering, and preprocessing the original gray-scale ultrasonic image to obtain a preprocessed ultrasonic image; performing elastic image generation on the preprocessed ultrasonic image through an elastic imaging generation network to obtain an elastic modulus diagram; performing super-resolution image reconstruction on the preprocessed ultrasonic image through a super-resolution reconstruction network to obtain a high-resolution image; performing feature extraction on the preprocessed ultrasonic image, the elastic modulus diagram and the high-resolution diagram to obtain a multi-modal hierarchical feature map; performing cross-modal attention fusion on the multi-modal hierarchical features to obtain a fusion feature map; and according to the fusion feature map, performing layering evaluation on the skin tissue layering to obtain a multi-skin tissue probability map. By adopting the method, the integrated skin tissue layering evaluation of the whole body skin, fascia and muscular tissues can be realized under the limitation of insufficient resolution.

The invention relates to the technical field of biology, and provides a probiotic composition for relieving sarcopenia obesity and application of the probiotic composition. The composition comprises at least two of lactobacillus plantarum, lactobacillus rhamnosus and bifidobacterium animalis subsp. Lactis. Wherein the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) No.25839; the preservation number of the lactobacillus rhamnosus is CGMCC (China General Microbiological Culture Collection Center) No.26968; the preservation number of the animal bifidobacterium subsp. Lactis is CGMCC (China General Microbiological Culture Collection Center) No. 27998. The composition disclosed by the invention can be used for increasing the muscle content of an organism, improving the muscle tissue form, increasing adenosine triphosphate and inhibiting abnormal increase of body weight, so that the composition can be used for effectively preventing and treating sarcopenia obesity.

The present invention provides a dance leg-kicking training device and a training method. The device includes a support frame, a rolling member, a traction rope, a leg fixing member, a driving mechanism and a sensor assembly. The rolling member is arranged on the support frame. The first end of the traction rope is wound around the rolling member, and its second end is connected to the leg fixing member. The driving mechanism is arranged on the support frame and connected to the rolling member, and is used for driving the rolling member to roll, so as to contract or extend the traction rope, and further lift or lower the leg. The sensor assembly is arranged at a relative interval with the support frame and electrically connected to the driving mechanism, and is used for controlling the driving mechanism to be in a static state when the leg kicks to a preset angle, so that the leg can stay at the preset angle, which can relax the muscle tissue of the thigh root and achieve the training effect of making the legs slender and straight. The present invention standardizes the action requirements and training skills of ground leg-kicking training through the dance leg-kicking training device, and improves the safety and autonomous training efficiency of leg-kicking training.

A muscle probe is provided for obtaining electromyography data and optical spectroscopy data from muscle tissue. The muscle probe comprises an elongate needle having an outer wall surrounding a needle interior, the needle interior comprising: a core electromyography electrode; and one or more optical fibres; wherein the needle is arranged to be inserted into a muscle, and further arranged to detect electrical activity from the muscle; and wherein the one or more optical fibres are arranged to direct incident light from a light source toward a target area of the muscle, and further arranged to receive scattered light from the target area. The present disclosure aims to provide a muscle probe to improve the diagnostic pathway for patients with neuromuscular disorders, by developing a minimally invasive bedside test of muscle health.

A testing device for determining a stiffness of a patient's tissue is provided herein that includes a probe housing, an internal probe housed in the probe housing, a load cell connected to the internal probe, and a linear-actuator connected to the load cell. The patient's tissue may be joint tissue, cervical tissue, uterine tissue, muscular tissue, and / or pulmonary tissue. The internal probe may be configured to translate within the probe housing, and the linear-actuator may be configured to move the load cell, causing translation of the internal probe within the probe housing. When the load cell is moved by the linear-actuator, the internal probe may translate within the probe housing, and a tip of the internal probe may cause indentation into a patient's tissue.

The invention relates to the field of pelvic floor muscle recovery treatment, in particular to a female pelvic floor muscle recovery treatment device and an adjusting structure thereof.The female pelvic floor muscle recovery treatment device comprises a movable base, a control box is arranged on the surface of the movable base, a hydraulic rod is installed on one side of the control box, and a recovery supporting plate is installed at the top of the hydraulic rod; a massage repairing device capable of massaging female pelvic floor muscles is installed on the upper surface of the repairing supporting plate, a movable structure is installed in the repairing supporting plate, and a lifting adjusting structure capable of freely moving is arranged above the repairing supporting plate. The top of the lifting adjusting structure is provided with an abdomen repairing structure capable of repairing female abdomen muscle tissue, and the matrix type layout of the massage vibrators can stimulate pelvic floor muscle groups in a partitioned mode, so that the biological feedback effect is enhanced. The leg repairing structure drives a sliding ball to move in an arc groove through an electric telescopic rod, switching between resistance training and passive stretching is achieved, and lower limb venous thrombosis is effectively prevented.

A system and method for controlling an orthosis. The system comprises: a pressure detection module (2), configured to detect pressure information of an orthosis pressure applying zone; a pressure control module (3), configured to adjust the pressure information applied by an orthosis (8) according to a received pressure adjustment instruction; a blood oxygen detection module (1), configured to detect blood oxygen information of the orthosis pressure applying zone; a temperature detection module (4), configured to detect temperature information of the orthosis pressure applying zone; a temperature control module (5), configured to adjust the temperature information applied by the orthosis (8) according to a received temperature adjustment instruction; a control platform, configured to determine whether to trigger the pressure adjustment instruction and the temperature adjustment instruction or not according to one or more of the received pressure information, blood oxygen information, and temperature information. The system can monitor the skin and muscle tissue conditions in the orthosis pressure applying zone in real time and provide early warning of abnormal conditions. Moreover, the system has a low cost and is worn comfortably and suitable for long-term wearing and daily monitoring.

The invention belongs to the field of biology, and discloses a method for identifying RNA (Ribonucleic Acid) binding protein in porcine intramuscular fat cells or subcutaneous fat cells, which comprises the following steps: step 1, taking porcine muscle tissues or subcutaneous fat tissues to carry out meat mashing and digestion, and collecting mature intramuscular fat cells or subcutaneous fat cells; step 2, washing intramuscular fat cells or subcutaneous fat cells, and carrying out cross-linking treatment by adopting ultraviolet irradiation; step 3, collecting intramuscular fat cells or subcutaneous fat cells after cross-linking treatment, and performing lysis under the action of a cell lysis solution to obtain a lysis solution; step 4, adding magnetic beads into the lysate, and carrying out repeated resuspension and elution to obtain an eluent; and 5, separating the RNA binding protein from the magnetic beads, and incubating. According to the method, intramuscular fat cells or subcutaneous fat cells are treated by adopting a UV cross-linking solidification method, and then RNA binding protein is captured through magnetic beads, so that the RNA binding protein is successfully obtained.

The invention provides a method for detecting fluorine compounds in shrimps, which comprises the following steps: S1, sample preparation: removing shells of to-be-detected shrimps, and crushing and homogenizing muscular tissues of the to-be-detected shrimps to obtain a to-be-detected sample; s2, extraction: extracting a sample to be detected, retaining an organic phase, and concentrating to obtain a concentrated solution; then adding water which is 5-15 times of the concentrated solution for dilution to obtain a to-be-purified solution; the extraction solvent is an aqueous solution of an organic solvent; s3, purification: purifying the to-be-purified liquid by using a solid-phase extraction column to obtain a purified liquid; s4, concentration and constant volume: concentrating the purified liquid to be nearly dry, redissolving, and filtering to obtain filtrate; and S5, sample detection: detecting the filtrate by using a liquid chromatograph-mass spectrometer, and carrying out qualitative and quantitative analysis on the fluorine compounds in the prawns by adopting a standard curve method. The method can be used for simultaneously determining the contents of 41 PFASs compounds with different physicochemical properties in shrimps.

The invention provides a tendinopathy rehabilitation training and monitoring system based on electrical stimulation, and the system comprises a detection unit which is used for measuring the electrical impedance of the tendon and muscular tissue of a patient before rehabilitation training, and providing a basis for the initial setting of electrical stimulation parameters; the electrical stimulation unit is used for monitoring the muscle contraction degree, the motion angle and the angular velocity, the blood oxygen metabolism condition of a tendon area and the pressure condition around muscles of the rehabilitation person under electrical stimulation in the rehabilitation training process. A muscle electrophysiological sensor, a joint angle sensor, a near infrared spectrum sensor, a motion capture sensor, a pressure pad sensor and the like are utilized, rehabilitation training conditions can be monitored from multiple aspects, a more detailed rehabilitation training report is generated in combination with various weight ratios, targeted training can be carried out on different individuals, various parameters can be adjusted, and the rehabilitation training efficiency is improved. The training effect is improved, training information can be fed back in time, and doctors can conveniently carry out whole-course coordination management on training.

The present invention relates to the field of biotechnology and discloses a probiotic composition for alleviating sarcopenic obesity and its use. The composition comprises at least two of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium animalis subsp. lactis; wherein the Lactobacillus plantarum has a deposit number of CGMCC No. 25839; the Lactobacillus rhamnosus has a deposit number of CGMCC No. 26968; and the Bifidobacterium animalis subsp. lactis has a deposit number of CGMCC No. 27998. The composition of the present invention can increase muscle mass, improve muscle tissue morphology, increase adenosine triphosphate, and inhibit abnormal weight gain, thereby effectively preventing and treating sarcopenic obesity.

Systems and methods can be implemented in which an electromagnetic charge is used to strengthen, tone, and firm muscle tissues. For example, the method may include receiving parameters for operation of a magnetic muscle stimulation device. The method may also include causing, based on the received parameters, a first alternating current having a first phase to flow through a first coil and generate a first time-varying magnetic field that induces a first electric charge in muscle tissue under a skin surface of a patient when the first applicator surface is positioned substantially on and parallel to the skin surface of the patient. The method may also include causing a second alternating current having a second phase to flow through a second coil in a similar manner. Optionally, a phase offset between the first and second phases may be adjusted to limit to a predetermined maximum electric charge.

The invention discloses a stomach cancer patient postoperative muscle recovery process visual monitoring platform and a multi-terminal cooperation method, and the method comprises the following steps: setting an initial scanning layer thickness for scanning according to the specific condition of a patient before CT examination; the CT scanning equipment is used for scanning and imaging the cross section of the postoperative muscular tissue of a gastric cancer patient, continuous dynamic image data are obtained by collecting scanning layer data in real time, and the real-time change condition in the muscular tissue is recorded. According to the intelligent prediction result of the convolutional neural network, the CT scanning layer thickness is automatically optimized in real time, and particularly, the scanning layer thickness is actively reduced when a high-risk gas sign is found, so that the image acquisition precision is remarkably improved, an abnormal gas region with relatively small volume and relatively low density in postoperative muscular tissue is better captured, and the postoperative muscular tissue quality is improved. Therefore, the space average effect and the missed diagnosis risk caused by traditional fixed layer thickness scanning are remarkably reduced.

The prostate detection device comprises a top frame, a Y-axis electric air cylinder is embedded in an inner cavity of the top frame, a piston rod of the Y-axis electric air cylinder is fixedly connected with a support, a top barrel is transversely fixed to the top, close to an alarm lamp, of the support, and bottom covers are fixedly connected to the two sides, away from the top barrel, of the support; a sampling assembly for prostate tissue fluid puncture is arranged on the top cylinder, and a sample mixing assembly for uniformly mixing the prostate tissue fluid and a detection reagent is arranged on the bottom cover. Firstly, tissue fluid samples in prostate tissues and muscle tissues are punctured and sampled through the piston head, and after tissue fluid sampling work of prostate pathological samples is completed, the tissue fluid samples and detection reagents in the two groups of reaction barrels are fully and uniformly mixed and react, so that various substances in the tissue fluid samples are fully separated out; subsequent detection work such as direct smear microscopic examination, smear staining microscopic examination and tetrazole nitrogen blue test is facilitated, and the comprehensiveness and accuracy of prostate detection are improved.

Disclosed herein are hydrogels that can be loaded with myogenic agents, for instance muscle stem cells (MuSCs) / satellite cells, pro-myogenic factors, and combinations thereof. The hydrogels can be contacted with damaged muscle tissue, thereby facilitating muscle growth and repair. Further provided are methods of repairing muscle tissue in a patient in need thereof, said methods comprising contacting the muscle tissue with a composition comprising the hydrogel. Also provided herein are kits comprising the hydrogel composition and a substrate comprising at least one microneedle.

The invention provides application of alpha-ketobutyrate in preparation of drugs for prevention and / or treatment of skeletal muscle atrophy, and belongs to the technical field of biomedicine.The human endogenous metabolite alpha-ketobutyrate is applied to prevention and treatment of skeletal muscle atrophy, the side effect is small, the safety is high after long-term use, and the effect is obvious. Serious immunoreaction or toxic reaction can be avoided, and skeletal muscle senescence and muscular atrophy can be effectively prevented and treated. The alpha-ketobutyrate can improve the muscle index of skeletal muscles of the old mice, increase the number of muscle fibers, increase the cross sectional area, increase the number of muscle cell nucleuses and the expression of nuclear fiber layer protein LamB1 of the muscle cell nucleuses, and can also increase the capillary angiogenesis rate in muscle tissues of the old mice. Alpha-ketobutyrate has good pharmacological characteristics and low side effects, and provides an important basis for developing clinical drugs for treating amyotrophy.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention discloses application of an FGF9 gene in regulation and control of growth and development of chicken skeletal muscles, and further discloses application of an overexpression vector of the FGF9 gene or an interference fragment of the overexpression vector in promotion or inhibition of proliferation and differentiation of chicken myoblasts. The invention also discloses a specific primer pair for detecting the expression quantity of the FGF9 influencing the growth and development of the chicken skeletal muscle. The invention also discloses a detection kit and a detection method thereof. The detection kit provided by the invention can be used for detecting the expression quantity of the FGF9 gene in chicken muscle tissues and myoblasts, and the detection method is simple and quick. The FGF9 gene can be used as an important gene for researching a chicken skeletal muscle growth and development regulation theory.

The present disclosure relates to nucleic acid regulatory cassettes that can be used to express transgene payloads in specific muscular tissue. Also included in the disclosure are vectors comprising the regulatory cassettes of the invention, including adeno-associated virus (AAV) vectors, and compositions and methods of treating genetic diseases or disorders also comprising the regulatory cassettes.

Systems and methods can be implemented in which an electromagnetic charge is used to strengthen, tone, and firm muscle tissues. For example, a magnetic muscle stimulation device may be provided that includes a processor and a device applicator having a housing and a coil positioned within in the housing. The processor may be configured to receive parameters for operation of the device applicator, and to cause, based on the received parameters, an alternating current to flow through the coil to generate a time-varying magnetic field that induces an integrated electric charge or electrical conductivity in a portion of tissue under a skin surface of a patient.

The invention discloses an electric shock simulation training detection and evaluation method, system and applet, and relates to the technical field of electric shock simulation training, and the method comprises the following steps: selecting an electrical stimulation instrument, applying a preset controllable electrical stimulation signal to a designated muscle area, and simulating an electrical signal of a real external environment under a precise control condition; the electric field change of muscular tissues in a delimited area is directly monitored through a micro field effect sensor, and the diffusion trend of charges is reflected in real time; electric field change data obtained in real time is preprocessed by applying a signal processing technology, then key features reflecting charge accumulation are extracted, and deep analysis is performed on the extracted key features. The electric field change in the muscular tissue is monitored in real time, the charge accumulation risk is recognized in advance through the deep learning model, the pulse duty ratio is automatically adjusted when the risk occurs, abnormal polarization and electrolytic reaction are effectively prevented, and the risks of tissue damage, cell necrosis and nerve damage are reduced.

The invention discloses a CircSESN1 gene as well as an overexpression vector, a specific primer pair, a detection kit and application of the CircSESN1 gene. The invention also discloses application of the CircSESN1 gene, an overexpression vector, the specific primer pair or the fluorescent quantitative detection kit in regulation and control of growth and development of chicken skeletal muscle. The invention also discloses a method for inhibiting chicken myoblast proliferation and / or promoting differentiation. The detection kit provided by the invention can be used for detecting the expression quantity of the CircSESN1 gene in chicken muscle tissues and myoblasts, and the detection method is simple and quick. The gene can be used as an important non-coding RNA for researching a regulation theory of growth and development of chicken skeletal muscles.

The present invention provides novel capsid variants for viral vectors that simultaneously detarget liver tissue and efficiently transduce muscular tissue.

The present invention provides a production method for a three-dimensional muscle tissue including the steps of: preparing an approximately rectangular first cell module containing skeletal myoblasts in a hydrogel, and having a plurality of approximately rectangular holes parallel to each other, and an approximately rectangular second cell module containing skeletal myoblasts in a hydrogel, and having a plurality of approximately rectangular holes parallel to each other at positions different from those of the first cell module in a vertical direction; alternately stacking the prepared first cell module and the prepared second cell module to obtain a stack; subjecting the skeletal myoblasts contained in the obtained stack to proliferation culture; and inducing the proliferated skeletal myoblasts to differentiate into myotubes.

The present disclosure provides double stranded ribonucleic acid (dsRNA) agents for inhibiting expression of a target gene, comprising an antisense strand which is complementary to the target gene; a sense strand which is complementary to the antisense strand and forms a double stranded region with the antisense strand; at least one alpha-v-beta-6 (αvβ6) integrin targeting ligand that mediates delivery to muscle tissue conjugated to at least one strand; and at least one in vivo delivery enhancing moiety conjugated to one or more internal positions on at least one strand. The present disclosure also provides compositions comprising such dsRNA agents, and methods of use thereof for treating a subject having a disorder that would benefit from reduction in expression of the target gene.

The invention belongs to the technical field of medical instruments, and provides a double-cavity knee joint injection device and method, the double-cavity knee joint injection device comprises a needle cylinder body, the needle cylinder body is provided with a main piston cylinder and at least one auxiliary piston cylinder, the inner cavity of the main piston cylinder and the inner cavity of the auxiliary piston cylinder communicate with each other, and the main piston cylinder and the auxiliary piston cylinder are movably connected with plungers; the needle cylinder body is further provided with a needle head end, an injection needle head is arranged at the needle head end, the main piston cylinder is in one-way communication with the injection needle head through a one-way valve, the one-way valve is in one-way communication towards the direction of the injection needle head, and the communication pressure of the one-way valve is adjustable. When an injection needle is inserted into non-target injection tissue, such as muscle, of a patient, the injection resistance of the muscle tissue is large, a one-way valve cannot be conducted in the injection process, so that injection liquid flows into an auxiliary piston cylinder, and a plunger retreats. Therefore, medical staff can conveniently judge whether the injection needle is inserted into a target position or not. And the injection is prevented from being mistakenly injected into other tissues to be wasted.

1. The name of this design product: low-frequency electrical stimulation device (host). 2. The purpose of this design product: to produce a therapeutic effect by outputting low-frequency pulse electrical stimulation and transmitting it into human muscle tissue. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

The invention relates to application of O-GlcNAc glycosylation in disuse atrophy resistance of myoblasts, and further relates to a method for improving disuse atrophy resistance of myoblasts, and the method comprises the step of improving the level of O-GlcNAc glycosylation of myoblasts. In the myoblasts with waste atrophy, the O-GlcNAc glycosylation level is obviously reduced, the atrophy of the myoblasts caused by waste conditions can be inhibited by up-regulating the O-GlcNAc glycosylation, and the atrophy of the myoblasts caused by the waste conditions can be intensified by down-regulating the O-GlcNAc glycosylation, so that the myoblasts with waste atrophy can be inhibited. And a new path is provided for detection and treatment of disuse atrophy of myoblasts and muscular tissues.

The present invention relates to the use of GRP78 and peptides similar thereto or nucleic acids encoding the same. The peptides or nucleic acids according to the present invention can increase the expression of biomarkers having reduced expression in senescent cells, and thus can be used to restore the function of muscle tissue that has decreased in function due to aging, etc.