64 results about "Uterine tissue" patented technology

The invention belongs to the technical field of microorganisms, and provides streptococcus salivarius subsp. Thermophilus HX-ST36, and the preservation number of the streptococcus salivarius subsp. Thermophilus HX-ST36 is CGMCC NO.32955. The streptococcus salivarius subsp. Thermophilus provided by the invention can be used for fermenting astragalus membranaceus-angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrheal model mouse, a fermentation product can remarkably inhibit the writhing reaction, and the effects of relieving dysmenorrheal and enriching blood can be achieved by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the content of hemoglobin (HGB). The dampness clearing effect of the fermentation product is verified by improving the heavy physical sign of moisture through crowd experiments. The invention also provides a preparation method of the probiotic preparation and the probiotic fermentation product. The preparation methods of the probiotic preparation and the probiotic fermentation product are simple, and large-scale production can be realized.

A testing device for determining a stiffness of a patient's tissue is provided herein that includes a probe housing, an internal probe housed in the probe housing, a load cell connected to the internal probe, and a linear-actuator connected to the load cell. The patient's tissue may be joint tissue, cervical tissue, uterine tissue, muscular tissue, and / or pulmonary tissue. The internal probe may be configured to translate within the probe housing, and the linear-actuator may be configured to move the load cell, causing translation of the internal probe within the probe housing. When the load cell is moved by the linear-actuator, the internal probe may translate within the probe housing, and a tip of the internal probe may cause indentation into a patient's tissue.

A device and method of use for preventing or treating postpartum uterine bleeding or hemorrhage of a patient. The device includes a suction tube having a distal end portion at which an aperture or an array of plural apertures is located and extending about the periphery of the distal portion. A sealing member having an apex and flexible sidewall is mounted on the suction tube so that a portion of its sidewall can be brought into engagement with tissue of the uterus. Suction from a vacuum source is applied to a proximal end portion of the suction tube to apply suction via the aperture(s) to the interior of the patient's uterus. The suction tube may include an illumination system for illuminating the interior of the patient's vagina.

A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in communication with distal balloon portion and medial balloon portion for expansion of said balloon portions.

The invention belongs to the technical field of gene editing, and discloses a construction method of a uterus specific conditional gene editing mouse based on a CRISPR-AsCas12a system. According to the invention, the efficient editing ability of AsCas12a is innovatively combined with the uterus tissue specific Pgr promoter. According to the invention, rapid and efficient single gene knockout, such as Ythdf1, Ythdf2 and Ythdf3, is realized in the uterus. The technology breaks through the limitation of long breeding period of the traditional Cre / loxP system, and tissue-specific knockout can be realized without homozygosis. The CRISPR / AsCas12a system provides an animal model for researching pregnancy-related diseases and hormone regulation mechanisms and developing a uterus targeted gene therapy. Reference is provided for exploring other gene editing model animals, and development of gene editing animal models in the veterinary field is broadened.

The present invention is applicable to the field of microbial technology, and provides a Bacillus subtilis, a bacterial agent and a composition and their application in preparing a product for preventing and treating endometritis. Bacillus subtilis M2022, taxonomically named Bacillus subtilis Bacillus subtilis ; The deposit number is CGMCC No.28555; the deposit date is September 25, 2023. Bacillus subtilis M2022 can alleviate the inflammatory response of uterine tissue caused by subacute rumen acidosis, reduce the levels of neutrophils, TNF‑α and IL‑1β in uterine lavage fluid, thereby alleviating the occurrence of endometritis in dairy goats. It has potential application prospects in the prevention and treatment of endometritis in dairy goats.

The invention belongs to the field of medical image processing, and provides an improved deep learning model based on U-Net for a placenta automatic segmentation task in a magnetic resonance imaging (MRI) image. Technical improvement key points are as follows: a convolutional block attention mechanism module (CBAM) is embedded in a down-sampling path, and the key channel and spatial feature extraction capability is enhanced; meanwhile, an edge perception enhancement module (BPM) is embedded, so that the edge distinction degree of the placenta and the uterus tissue is enhanced; in addition, an attention gating module (AG) is additionally arranged on an up-sampling path, the semantic distinguishing capability of a placenta target area and a background is improved, and background noise interference is reduced. Experimental verification shows that the segmentation precision of the model in a placenta MRI automatic segmentation task is obviously superior to that of an existing method.

The invention relates to the technical field of functional food, in particular to a polypeptide composition for regulating menstruation and nourishing blood and a preparation method thereof, and the polypeptide composition comprises the following raw materials: a Chinese wolfberry extract, an astaxanthin-fish oil co-coated preparation, a red algae oligosaccharide iron complex, maltodextrin and folic acid. In the polypeptide composition for regulating menstruation and nourishing blood and the preparation method thereof, the astaxanthin-fish oil co-coated preparation stably wraps the strong antioxidant astaxanthin and the fish oil through a complex coacervation microencapsulation technology, so that excessive free radicals generated by menstrual physiological stress can be efficiently eliminated, inflammatory response of uterine tissues can be relieved, and discomfort symptoms such as dysmenorrhea and the like can be relieved; according to the red algae oligosaccharide iron complex, oligosaccharide is used as a natural carrier of an iron element and is absorbed in an oligosaccharide iron chelating form in intestinal tracts, the absorption way of traditional ferric salt is avoided, the bioavailability is greatly improved, the iron element can be efficiently and mildly supplemented, and iron-deficiency anemia is improved.

The utility model discloses a disposable uterine cavity tissue suction bottle which comprises a collecting bottle, a bottle cap is detachably connected to the upper portion of the collecting bottle, an end cap connecting cylinder is arranged on the bottle cap, an end cap is detachably connected to the end cap connecting cylinder, and a filter screen piece is detachably connected to the lower end of the end cap. A suction opening is formed in the end cover; the bottle cap is provided with a negative pressure connector, and the negative pressure connector penetrates through the bottle cap to be connected with an overflow stopping valve. A vacuum hole is formed in the side portion of the bottle cap and communicated with the negative pressure connector. Separation of tissue and liquid can be achieved only by taking out the end cover, and the tissue separation device is simple in structure and convenient to use.

Disclosed herein is a vapor therapy device for producing intra-uterine tissue effects. The device can include a shaft, including a proximal portion and a distal portion, a fluid-expandable medium, near the distal portion of the shaft, a fluid-delivery conduit, extending between the proximal portion and the distal portion of the shaft, the fluid-delivery conduit comprising an outlet, near the distal portion of the shaft, for delivery of the fluid toward the medium, and an in vivo heat generator, near the distal portion of the shaft, to heat the fluid. A method of treating a patient for menorrhagia with the device can include introducing a medium, in a contracted state, into a patient, delivering a fluid toward the medium to expand the medium in vivo; generating heat in vivo on or near the medium to vaporize the fluid, and exposing a treatment site to the vaporized fluid.

The invention discloses an ultrasonic robot gynecological autonomous scanning method and a related device and equipment. The method comprises the following steps: performing multi-tissue segmentation on a real-time ultrasonic image to obtain a uterus contour point set; the minimum left boundary included angle and the minimum right boundary included angle are determined every time the probe moves by one step length; judging whether at least one of the minimum left boundary included angle and the minimum right boundary included angle is smaller than a preset included angle threshold value or not; if yes, controlling the probe to move up and down and swing; when the probe moves by one step length, finding an area with the longest continuous shielding in the uterus contour point set, and determining the length of the area as the shielding length at the current moment; judging whether the shielding length at the current moment is greater than a preset length threshold; if yes, the probe is controlled to swing according to the shielding length at the current moment and a preset length threshold value; and controlling the probe to scan the left and right ovaries according to a preset path. By means of the method, it can be guaranteed that the uterus tissue is not shielded, image missing detection is effectively avoided, and the ultrasonic image quality is improved.

The invention provides an oxytocin injection precise administration method based on physiological pharmacokinetics (PBPK) model optimization, and relates to the technical field of individualized drug administration. According to the method, firstly, individual physiological parameter information of a target receptor is collected, an individual PBPK model is constructed, simulation operation is carried out in combination with drug characteristics of oxytocin, and in-vivo drug distribution under different drug administration schemes is predicted. By evaluating the drug concentration, the drug administration duration and the uterine contraction reaction predicted value of each scheme in the uterine tissue and system circulation, the optimal drug administration parameter combination meeting the drug efficacy and safety requirements at the same time is screened from the drug concentration, the drug administration duration and the uterine contraction reaction predicted value. An injection control command is generated based on the combination, and precise infusion is performed through an injector system with a program control function. According to the method, individualized precise regulation and control based on model driving are achieved, and the safety and clinical effect of oxytocin medication are effectively improved.

The invention discloses a preparation method for constructing a mouse embryo implantation failure model based on fusobacterium variabilis, and belongs to the technical field of animal models. The method comprises the following steps: carrying out anaerobic culture on fusobacterium varium, giving the fusobacterium varium to a female C57 mouse through an intragastric administration way, continuously treating for 28 days, and inducing the female C57 mouse to have a phenotype that the number of implanted embryos is reduced and the expression of a vascular endothelial growth factor (VEGF) in a uterine tissue is reduced. According to the method, embryo implantation failure caused by intestinal flora imbalance is simulated through the'intestine-uterus axis' for the first time, a reliable animal model is provided for studying the causal relationship between flora and pregnancy failure, and the method has important scientific research and clinical application value.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. Specifically, the traditional Chinese medicine composition is prepared from radix salviae miltiorrhizae, rhizoma coptidis, rhizoma anemarrhenae, radix ophiopogonis, nacre mother of pearl and semen ziziphi spinosae. The traditional Chinese medicine composition provided by the invention is simple in formula, does not contain precious, thin, toxic and endangered medicinal materials, and in a naturally aged female climacteric mouse model, the traditional Chinese medicine composition formula can obviously increase the level of E2 in plasma, lower the levels of FSH and LH and improve the pathological characteristics of uterus tissues. Test results show that the traditional Chinese medicine composition provided by the invention has a certain treatment effect on patients with perimenopausal syndromes.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

A uterine tissue resection system may include a housing enclosing a power source such as a battery, a motor, and a control board for regulating power to the motor and the battery. Extending distally from the housing may be a cutting assembly comprising an outer cutting tube with an inner cutting tube received therein. The inner cutting tube may be fluidly coupled to an external suction source through a swivel connection interface. The housing may further contain a drive assembly connecting the inner cutting tube to a driveshaft of the motor so that rotation of the driveshaft results in simultaneous rotation and reciprocation of the inner cutting tube.

A body fluid conditioning device includes an inner tube disposed inside an outer tube with a gap therebetween, the inner tube being formed with a hole, the hole of the inner tube having a size larger than a size of a hole formed in the outer tube. A fluid adapter is sealingly coupled to the proximal portion of the inner tube. The fluid adapter includes a vacuum port adapted to be coupled to a vacuum source for generating a negative pressure in the inner tube. The outer tube is adapted to press uterine tissue against the outer tube. And the expansion plug is arranged on the outer pipe.

The present disclosure relates to heterogeneous cell compositions derived from canine or feline uterine tissue and methods of producing and use thereof. In some aspects, the heterogeneous cell compositions comprise a mixture of mesenchymal progenitor cells and epithelial progenitor cells. In some aspects, the heterogeneous cell compositions are used as an autologous or allogeneic treatment for the treatment of diseases such as chronic kidney disease, atopic dermatitis, immune mediated arthritis, hepatitis, liver disease, inflammatory bowel disease, osteoarthritis, intravertebral disc disease, keratoconjunctivitis sicca (dry eye), pancreatitis, fibrosis, sclerosis, amyloidosis, immune mediated polyarthritis or wounds in canines and felines.

A composition comprising a decellularized uterine tissue-derived extracellular matrix and a use thereof and, more specifically, a hydrogel composition for three-dimensional culturing an endometrial organoid, a preparation method therefor, and a use thereof are described. The hydrogel composition comprising a decellularized uterine tissue-derived extracellular matrix can be utilized to fabricate an endometrial organoid highly similar to in vivo uterine tissues and organs through the properties, components, and physical properties of the decellularized uterine tissue-derived extracellular matrix, and such endometrial organoids can be advantageously used for in-vivo implantation and in drug tests for various uterus-related diseases.

The invention belongs to the technical field of cell biology and regenerative medicine, and particularly relates to a pig endometrial mesenchymal stem cell separation culture method and application, separation is carried out from uterus tissue of a large animal, namely, a pig, the steps are simple, the cell obtaining amount is large, the cultured endometrial mesenchymal stem cells have phenotypes of CD34-and CD11b-, and CD44 + and CD105 +, and the endometrial mesenchymal stem cells can be used for separating and culturing the endometrial mesenchymal stem cells. In vitro induced differentiation into bone cells, adipocytes and chondrocytes, during culture, collagen in extracellular matrix is decomposed, DNA is degraded, cell agglutination is reduced and effective digestion of tissues is promoted jointly through combined use of type II collagenase and DNase I, and a high-quality single-cell suspension can be obtained for subsequent centrifugation and culture; cells with intrauterine adhesion, skin and blood vessel injury and the like can be repaired, the repairing method is simple and easy to implement, regeneration and repairing can be performed by compositely implanting the material and a biological material into a focus part, and a new way is provided for cell transplantation treatment.

A device for endometrial ablation includes a selectively expandable bladder configured for insertion through a cervical canal of a patient and into a patient's cervix. The selectively expandable bladder defines an interior volume for receiving a thermally conductive medium which, when introduced into the interior volume, expands the selectively expandable bladder against the uterine tissue of the cervix. One or more insulative substrates is operably disposed within the interior volume and supports a thermal assembly on the one or more insulative substrates. The thermal assembly couples to an energy source and is configured to conduct thermal energy to a thermally conductive substrate upon activation of the thermal assembly, which, in turn, heats the thermally conductive medium in contact with the thermally conductive substrate to treat the uterine tissue of a patient.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

This invention discloses a cervical thermocoagulation device, belonging to the field of surgical diagnostic and therapeutic instrument technology. It includes a basic component comprising an operating rod, which consists of a handle and a shaft tube, and a treatment head connected to one end of the shaft tube. An expansion component includes an elastic mesh tube, a fixing ring, and a permanent magnet ring fixedly connected to both ends of the elastic mesh tube. In its natural state, the elastic mesh tube is shaped like a date pit with a radial bulge in the middle. The fixing ring is fixedly connected to the end of the shaft tube near the treatment head, and the permanent magnet ring is sleeved on the shaft tube and located on the side of the fixing ring opposite to the treatment head. This invention uses the radial expansion of the elastic mesh tube to form a hollow channel and open the cervical wall, allowing for full exposure of the lesion and a continuously clear surgical field. Relying on the superelastic properties of the elastic mesh tube, the treatment head can be flexibly adjusted within a safe range, while avoiding the safety hazard of burns to the cervical canal or normal uterine tissue due to accidental insertion.

The invention relates to the technical field of medical auxiliary instruments, in particular to a laparoscopic surgery-based uterus manipulator auxiliary device which is mounted on a uterus lifting rod of an existing balloon type uterus manipulator and comprises a sensing part and an equipment part, the sensing part comprises a plurality of auxiliary bags, attaching layers are arranged at the bottoms of the auxiliary bags, and the auxiliary bags adhere to the outer side wall of the balloon of the uterus lifting head through the attaching layers; the equipment part comprises a connector assembly, and the multiple auxiliary bags communicate with the connector assembly. The equipment part further comprises an attached shell, the attached shell is of an annular structure, a plurality of contact grooves are formed in the outer side of the attached shell, pressed feedback assemblies are arranged in the contact grooves, and the pressed feedback assemblies communicate with the auxiliary bags in a one-to-one correspondence mode; the pressure sensing part is integrated on an existing balloon type uterine manipulator to capture the pressure change of the uterine tissue, the equipment part is integrated to transmit the sensing feedback information of the compressive strength of the inner wall of the uterus of a patient to an operator, and the defect that the operator of the existing uterine manipulator cannot visually sense the compressive strength of the uterine tissue in real time is overcome.

The application discloses a device for taking out an IUD, and relates to the technical field of gynecological instruments, comprising a measuring unit arranged in each jaw; the measuring unit comprises a plurality of jaw teeth hingedly connected to the interior of the jaw, a traction line penetrating through the interior of the jaw and the handle and being in contact with the jaw teeth, a traction part fixed to the end of the traction line, and a first spring sleeved on the outside of the traction line. The device has the beneficial effect that the cooperation between the jaw teeth arranged in the jaw and the traction line, and the characteristic difference between the reaction force of the hard IUD and the soft uterine tissue on the jaw teeth are utilized to realize the accurate identification and feedback indication of the target material.

This invention discloses a mouse experimental method for detecting the tissue distribution of exogenous oxytocin, belonging to the field of biotechnology. Specifically, oxytocin is injected into or nasally sprayed into oxytocin knockout mice, and body tissues, including but not limited to brain tissue, mammary gland tissue, blood, heart tissue, uterine tissue, bone tissue, and muscle tissue, are collected at different time points. The tissue distribution and content of oxytocin are then detected using liquid chromatography-mass spectrometry (LC-MS / MS). This experimental method allows for a wider range of experimental samples, not just focusing on brain tissue and blood; it also has higher sensitivity and stronger specificity; and by utilizing oxytocin gene knockout mice, it eliminates the influence of endogenous oxytocin, providing certain assistance for subsequent animal experiments and clinical research on oxytocin.

The utility model discloses a curette for gynaecology and obstetrics operation, which belongs to the technical field of curette equipment, and comprises a curette for gynaecology and obstetrics operation treatment, the curette comprises a handle, a connecting rod and a curette for scraping uterus tissues of a patient, the connecting rod is connected with the handle, and the connecting rod is connected with the handle. A connecting head capable of being connected with a traditional medical aspirator is arranged on the side of the tail end of the connecting rod, the connecting head is communicated with the interior of the connecting rod, a drainage hole is formed in the spatula, and the drainage hole is communicated with the interior of the connecting rod. In the process that the tissue is taken out through the curette, the aspirator can be connected with the connector in a sleeved mode, waste tissue and residual blood can be sucked out through the curette and the connecting rod during treatment through starting of the aspirator, and on the basis that a good treatment view is provided for medical staff, the treatment effect of a needed operation is improved.

The fluid regulating device includes an inner tube disposed within an outer tube, with a gap between the inner tube and the outer tube, and an opening formed in the inner tube that is larger in size than the opening formed in the outer tube. A fluid adapter is sealingly coupled to a proximal portion of the inner tube. The fluid adapter includes a vacuum port adapted to be coupled to a vacuum source to generate negative pressure within the inner tube. The outer tube is adapted to be pressed against uterine tissue. An inflatable plug is disposed in the outer tube.

The invention belongs to the technical field of gene editing, and discloses a site-directed knock-in heterozygote mouse of conditional overexpression SaCas9 gene and a preparation method and application thereof. Based on the bottleneck of the prior art, the invention provides an innovative solution for constructing the uterus specific conditional editing mouse based on the CRISPR / SaCas9 system. The efficient editing ability of SaCas9 is innovatively combined with the uterus tissue specific Pgr promoter. Rapid and efficient single gene editing is realized in the uterus, such as activation expression of Egfp and specific conditional knockout of Ythdc2. The system breaks through breeding limitation of a traditional Cre system, and rapid and accurate editing is achieved. The system not only can remarkably shorten the model construction period, but also can provide an animal model for diseases such as reproductive disorder or infertility.

A body fluid regulating apparatus includes an inner tube disposed inside an outer tube with a gap between the inner and outer tubes, the inner tube being formed with apertures that are larger in size than apertures formed in the outer tube. A fluid adaptor is sealingly coupled to a proximal portion of the inner tube. The fluid adaptor includes a vacuum port adapted to be coupled to a vacuum source for creating a negative pressure in the inner tube. The outer tube is adapted for uterine tissue to press thereagainst. An inflatable plug is disposed on the outer tube.