31 results about "Uterine tissue" patented technology

The invention belongs to the field of medical image processing, and provides an improved deep learning model based on U-Net for a placenta automatic segmentation task in a magnetic resonance imaging (MRI) image. Technical improvement key points are as follows: a convolutional block attention mechanism module (CBAM) is embedded in a down-sampling path, and the key channel and spatial feature extraction capability is enhanced; meanwhile, an edge perception enhancement module (BPM) is embedded, so that the edge distinction degree of the placenta and the uterus tissue is enhanced; in addition, an attention gating module (AG) is additionally arranged on an up-sampling path, the semantic distinguishing capability of a placenta target area and a background is improved, and background noise interference is reduced. Experimental verification shows that the segmentation precision of the model in a placenta MRI automatic segmentation task is obviously superior to that of an existing method.

The invention relates to the technical field of functional food, in particular to a polypeptide composition for regulating menstruation and nourishing blood and a preparation method thereof, and the polypeptide composition comprises the following raw materials: a Chinese wolfberry extract, an astaxanthin-fish oil co-coated preparation, a red algae oligosaccharide iron complex, maltodextrin and folic acid. In the polypeptide composition for regulating menstruation and nourishing blood and the preparation method thereof, the astaxanthin-fish oil co-coated preparation stably wraps the strong antioxidant astaxanthin and the fish oil through a complex coacervation microencapsulation technology, so that excessive free radicals generated by menstrual physiological stress can be efficiently eliminated, inflammatory response of uterine tissues can be relieved, and discomfort symptoms such as dysmenorrhea and the like can be relieved; according to the red algae oligosaccharide iron complex, oligosaccharide is used as a natural carrier of an iron element and is absorbed in an oligosaccharide iron chelating form in intestinal tracts, the absorption way of traditional ferric salt is avoided, the bioavailability is greatly improved, the iron element can be efficiently and mildly supplemented, and iron-deficiency anemia is improved.

Disclosed herein is a vapor therapy device for producing intra-uterine tissue effects. The device can include a shaft, including a proximal portion and a distal portion, a fluid-expandable medium, near the distal portion of the shaft, a fluid-delivery conduit, extending between the proximal portion and the distal portion of the shaft, the fluid-delivery conduit comprising an outlet, near the distal portion of the shaft, for delivery of the fluid toward the medium, and an in vivo heat generator, near the distal portion of the shaft, to heat the fluid. A method of treating a patient for menorrhagia with the device can include introducing a medium, in a contracted state, into a patient, delivering a fluid toward the medium to expand the medium in vivo; generating heat in vivo on or near the medium to vaporize the fluid, and exposing a treatment site to the vaporized fluid.

The invention provides an oxytocin injection precise administration method based on physiological pharmacokinetics (PBPK) model optimization, and relates to the technical field of individualized drug administration. According to the method, firstly, individual physiological parameter information of a target receptor is collected, an individual PBPK model is constructed, simulation operation is carried out in combination with drug characteristics of oxytocin, and in-vivo drug distribution under different drug administration schemes is predicted. By evaluating the drug concentration, the drug administration duration and the uterine contraction reaction predicted value of each scheme in the uterine tissue and system circulation, the optimal drug administration parameter combination meeting the drug efficacy and safety requirements at the same time is screened from the drug concentration, the drug administration duration and the uterine contraction reaction predicted value. An injection control command is generated based on the combination, and precise infusion is performed through an injector system with a program control function. According to the method, individualized precise regulation and control based on model driving are achieved, and the safety and clinical effect of oxytocin medication are effectively improved.

The invention discloses a preparation method for constructing a mouse embryo implantation failure model based on fusobacterium variabilis, and belongs to the technical field of animal models. The method comprises the following steps: carrying out anaerobic culture on fusobacterium varium, giving the fusobacterium varium to a female C57 mouse through an intragastric administration way, continuously treating for 28 days, and inducing the female C57 mouse to have a phenotype that the number of implanted embryos is reduced and the expression of a vascular endothelial growth factor (VEGF) in a uterine tissue is reduced. According to the method, embryo implantation failure caused by intestinal flora imbalance is simulated through the'intestine-uterus axis' for the first time, a reliable animal model is provided for studying the causal relationship between flora and pregnancy failure, and the method has important scientific research and clinical application value.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

A uterine tissue resection system may include a housing enclosing a power source such as a battery, a motor, and a control board for regulating power to the motor and the battery. Extending distally from the housing may be a cutting assembly comprising an outer cutting tube with an inner cutting tube received therein. The inner cutting tube may be fluidly coupled to an external suction source through a swivel connection interface. The housing may further contain a drive assembly connecting the inner cutting tube to a driveshaft of the motor so that rotation of the driveshaft results in simultaneous rotation and reciprocation of the inner cutting tube.

The present disclosure relates to heterogeneous cell compositions derived from canine or feline uterine tissue and methods of producing and use thereof. In some aspects, the heterogeneous cell compositions comprise a mixture of mesenchymal progenitor cells and epithelial progenitor cells. In some aspects, the heterogeneous cell compositions are used as an autologous or allogeneic treatment for the treatment of diseases such as chronic kidney disease, atopic dermatitis, immune mediated arthritis, hepatitis, liver disease, inflammatory bowel disease, osteoarthritis, intravertebral disc disease, keratoconjunctivitis sicca (dry eye), pancreatitis, fibrosis, sclerosis, amyloidosis, immune mediated polyarthritis or wounds in canines and felines.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

This invention discloses a cervical thermocoagulation device, belonging to the field of surgical diagnostic and therapeutic instrument technology. It includes a basic component comprising an operating rod, which consists of a handle and a shaft tube, and a treatment head connected to one end of the shaft tube. An expansion component includes an elastic mesh tube, a fixing ring, and a permanent magnet ring fixedly connected to both ends of the elastic mesh tube. In its natural state, the elastic mesh tube is shaped like a date pit with a radial bulge in the middle. The fixing ring is fixedly connected to the end of the shaft tube near the treatment head, and the permanent magnet ring is sleeved on the shaft tube and located on the side of the fixing ring opposite to the treatment head. This invention uses the radial expansion of the elastic mesh tube to form a hollow channel and open the cervical wall, allowing for full exposure of the lesion and a continuously clear surgical field. Relying on the superelastic properties of the elastic mesh tube, the treatment head can be flexibly adjusted within a safe range, while avoiding the safety hazard of burns to the cervical canal or normal uterine tissue due to accidental insertion.

The invention relates to the technical field of medical auxiliary instruments, in particular to a laparoscopic surgery-based uterus manipulator auxiliary device which is mounted on a uterus lifting rod of an existing balloon type uterus manipulator and comprises a sensing part and an equipment part, the sensing part comprises a plurality of auxiliary bags, attaching layers are arranged at the bottoms of the auxiliary bags, and the auxiliary bags adhere to the outer side wall of the balloon of the uterus lifting head through the attaching layers; the equipment part comprises a connector assembly, and the multiple auxiliary bags communicate with the connector assembly. The equipment part further comprises an attached shell, the attached shell is of an annular structure, a plurality of contact grooves are formed in the outer side of the attached shell, pressed feedback assemblies are arranged in the contact grooves, and the pressed feedback assemblies communicate with the auxiliary bags in a one-to-one correspondence mode; the pressure sensing part is integrated on an existing balloon type uterine manipulator to capture the pressure change of the uterine tissue, the equipment part is integrated to transmit the sensing feedback information of the compressive strength of the inner wall of the uterus of a patient to an operator, and the defect that the operator of the existing uterine manipulator cannot visually sense the compressive strength of the uterine tissue in real time is overcome.

This invention discloses a mouse experimental method for detecting the tissue distribution of exogenous oxytocin, belonging to the field of biotechnology. Specifically, oxytocin is injected into or nasally sprayed into oxytocin knockout mice, and body tissues, including but not limited to brain tissue, mammary gland tissue, blood, heart tissue, uterine tissue, bone tissue, and muscle tissue, are collected at different time points. The tissue distribution and content of oxytocin are then detected using liquid chromatography-mass spectrometry (LC-MS / MS). This experimental method allows for a wider range of experimental samples, not just focusing on brain tissue and blood; it also has higher sensitivity and stronger specificity; and by utilizing oxytocin gene knockout mice, it eliminates the influence of endogenous oxytocin, providing certain assistance for subsequent animal experiments and clinical research on oxytocin.

The utility model discloses a curette for gynaecology and obstetrics operation, which belongs to the technical field of curette equipment, and comprises a curette for gynaecology and obstetrics operation treatment, the curette comprises a handle, a connecting rod and a curette for scraping uterus tissues of a patient, the connecting rod is connected with the handle, and the connecting rod is connected with the handle. A connecting head capable of being connected with a traditional medical aspirator is arranged on the side of the tail end of the connecting rod, the connecting head is communicated with the interior of the connecting rod, a drainage hole is formed in the spatula, and the drainage hole is communicated with the interior of the connecting rod. In the process that the tissue is taken out through the curette, the aspirator can be connected with the connector in a sleeved mode, waste tissue and residual blood can be sucked out through the curette and the connecting rod during treatment through starting of the aspirator, and on the basis that a good treatment view is provided for medical staff, the treatment effect of a needed operation is improved.

The fluid regulating device includes an inner tube disposed within an outer tube, with a gap between the inner tube and the outer tube, and an opening formed in the inner tube that is larger in size than the opening formed in the outer tube. A fluid adapter is sealingly coupled to a proximal portion of the inner tube. The fluid adapter includes a vacuum port adapted to be coupled to a vacuum source to generate negative pressure within the inner tube. The outer tube is adapted to be pressed against uterine tissue. An inflatable plug is disposed in the outer tube.

A body fluid regulating apparatus includes an inner tube disposed inside an outer tube with a gap between the inner and outer tubes, the inner tube being formed with apertures that are larger in size than apertures formed in the outer tube. A fluid adaptor is sealingly coupled to a proximal portion of the inner tube. The fluid adaptor includes a vacuum port adapted to be coupled to a vacuum source for creating a negative pressure in the inner tube. The outer tube is adapted for uterine tissue to press thereagainst. An inflatable plug is disposed on the outer tube.

The embodiment of the invention discloses a mammal ovulation prediction method and system based on multi-source clinical information fusion, and the method comprises the steps: obtaining the medical image data of a target animal generated in a conventional clinical examination process, and carrying out the preprocessing of the obtained medical image data; performing analysis according to the follicle image to obtain reference ovulation remaining time and a reference ovulation state in a preset time window; analyzing according to the cervical image to obtain an ovulation stage evaluation result; analyzing according to the uterus image to obtain the corresponding ovulation condition for reflecting the state change of the uterus tissue; and generating a comprehensive ovulation prediction result of the target animal according to the ovulation remaining time, a reference ovulation state in a preset time window, an ovulation stage evaluation result, a result obtained by uterus image analysis and an artificial experience evaluation result. Therefore, an ovulation prediction result which is available in small samples, easy to deploy, high in interpretability, accurate in prediction result and stable can be provided based on conventional clinical data.

1. The name of the design product: uterine tissue resection power system. 2. The use of the design product: suitable for gynecological endoscopic surgery, providing mechanical power for the matched disposable hysteroscopic tissue cutter. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. The name of the design product: uterine tissue resection device. 2. The use of the design product: the design product is used in medical and health services, mainly for the power system and resection device of uterine tissue resection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1. 5. Other circumstances that need to be explained: the enlarged view C part is transparent material.

This invention provides a precise dosing method for oxytocin injection based on a physiological pharmacokinetic (PBPK) model, belonging to the field of personalized drug delivery technology. The method first collects individual physiological parameter information of the target receptor, constructs a personalized PBPK model, and performs simulation calculations based on the drug characteristics of oxytocin to predict the in vivo drug distribution under different dosing regimens. By evaluating the drug concentration, dosing duration, and predicted uterine contraction response of each regimen in uterine tissue and systemic circulation, the optimal combination of dosing parameters that simultaneously meets the requirements of efficacy and safety is selected. Based on this combination, injection control instructions are generated, and precise infusion is implemented through a syringe system with programmable control functionality. This method achieves model-driven personalized precision control, effectively improving the safety and clinical efficacy of oxytocin administration.

This invention belongs to the field of biomedicine, specifically relating to the use of gemmaconazole in the preparation of drugs for treating primary dysmenorrhea. Gemarazole of this invention can significantly reduce the release of prostaglandins in uterine tissue, thereby relieving uterine smooth muscle spasms, reducing endometrial congestion and inflammatory responses, and thus alleviating pain, thus playing a role in treating primary dysmenorrhea. This provides a new option for clinical treatment of primary dysmenorrhea and has good application prospects.

The utility model discloses an animal uterine cavity adhesion model curettage device relates to medical instrument technical field, and its technical key points include the shell, the inside of shell is provided with the accommodating groove, the inner wall fixed mounting of accommodating groove who opens in the shell is provided with low speed motor, the output fixed mounting of low speed motor has the transmission shaft, the one end of transmission shaft away from low speed motor is penetrated to the shell outside and is fixedly connected with the pivot, the one side of pivot is provided with the connecting groove. Technical effect is drill bit to be bullet head design, is favorable to the expansion of animal uterus and is convenient to guide whole twist drill to enter the uterus inside, and the drill body is the screw thread structure design, and the drill body of screw thread structure design can effectively scrape the endometrium when rotating, and its structure is not the sharp blade design, and will not cause the cutting of uterine tissue, the puncture damage such as, and drill can be screwed and connected in the connecting groove inside, and screw connection can be convenient to dismantle to drill in the later period.

The application discloses a ginger and jujube group formula, a preparation method thereof and application of the ginger and jujube group formula in prevention and treatment of cold syndrome primary dysmenorrhea products. The ginger and jujube group formula is composed of ginger, jujube, white peony root and fried licorice in a specific ratio, and an extract can be prepared by using a water extraction, alcohol extraction or water extraction and alcohol precipitation process. Experiments prove that the group formula and the extract can improve the cold and blood stasis signs of a cold syndrome primary dysmenorrhea model mouse, reduce writhing responses, reduce uterine and ovarian pathological injuries, down-regulate serum and uterine tissue inflammatory factor levels, and regulate endocrine and microcirculation disorders. The application has the advantages of scientific compatibility, definite curative effect, stable preparation process, high safety, suitability for long-term conditioning and the like, and is used for preventing and treating cold evil invasion and cold and blood stasis type primary dysmenorrhea.

This invention relates to the field of medical device technology and discloses a uterine tissue aspiration device suitable for obstetrics and gynecology, comprising a suction box, a housing fixedly connected to the right side of the suction box, an adjustment component disposed within the housing's inner cavity, a piston disposed within the suction box's inner cavity, a movable rod fixedly connected to the right side of the piston, a first suction tube connected to the left side of the suction box, and a threaded bottle cap fixedly connected to the left side of the suction box and below the first suction tube. This invention, by setting an adjustment component, drives the piston to perform precise linear reciprocating motion within the suction box. Combined with a controller, the speed and direction of the motor can be precisely controlled, thereby achieving linear and stable adjustment of the negative pressure and suction rate within the suction box. This avoids pressure fluctuations from manual operation and the impact of the electric pump, allowing for the setting of optimal pressure according to surgical needs, effectively reducing the risk of endometrial damage, uterine perforation, or tissue residue caused by improper suction, and improving the safety and success rate of the surgery.

The invention discloses rhodococcus capable of improving eggshell quality, uterine tissue damage and energy metabolism of old laying hens and application of the rhodococcus. The invention belongs to the field of microorganisms, and particularly relates to rhodococcus capable of improving eggshell quality, uterine tissue damage and energy metabolism of old laying hens and application of the rhodococcus. The Rhodococcus ruber disclosed by the invention is Rhodococcus ruber NML-01, and the registration number of the Rhodococcus ruber NML-01 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms is CGMCC No.36760. The NML-01 strain can effectively increase the eggshell thickness of old laying hens, contributes to reducing the egg breaking rate and prolonging the egg laying cycle and economic utilization period of the laying hens, can reduce oxidative stress (MDA) and DNA damage (rH2AX) of uterine tissues, activates mitochondrial autophagy by up-regulating a PINK1 / PARK pathway, and improves the respiratory chain complex IV activity and ATP level.

Featured are compositions, methods, and apparatuses for biosynthetic organs, or organoids, that replicate tissues of the human female reproductive system (e.g., ovarian or uterine tissues). In particular, the disclosure features methods of culturing or 2024 / 054644 producing organoids or uteroids from pluripotent stem or progenitor cells and using the resulting organoids or uteroids to screen for safe and effective pharmaceutical interventions for diseases of interest. Such methods and compositions are particularly useful for the treatment of patients undergoing hormone replacement therapy (HRT) and / or assisted reproduction technology (ART) procedures, such as in vitro fertilization and in vitro oocyte maturation.WO

This invention provides a composition with menstrual regulating and blood-activating effects and its application in the preparation of external products, relating to the field of biomedical technology. This invention utilizes a composition composed of Chinese herbal raw materials including *Cephalotaxus fortunei* bark, star anise, *Erigeron breviscapus*, *Piper longum*, *Caulis thunbergii*, *Radix Achyranthis Bidentatae*, *Radix Scutellariae*, *Radix Achyranthis Bidentatae*, *Radix Panax notoginseng*, *Radix Bambusae in Taeniam*, and *Radix Achyranthis Bidentatae* to prepare a traditional Chinese medicine acupoint patch for treating or improving primary dysmenorrhea. The herbal acupoint patch can inhibit the expression of inflammatory factors, downregulate the expression level of COX-2, thereby inhibiting PGF2α, increasing the level of PGE2, and reducing uterine tissue inflammation, achieving multi-target treatment of primary dysmenorrhea. The herbal acupoint patch utilizes the power of the medicine through the acupoint, and the acupoint utilizes the properties of the medicine. The meridians are the channels, and the acupoints are the gateways. The medicinal power directly reaches the Chong and Ren meridians and the uterus, so that cold is warmed and dispelled, blood stasis is cleared and eliminated, and qi and blood flow smoothly, thus curing dysmenorrhea. It plays a role in warming the meridians and dispelling cold, promoting qi and blood circulation, removing blood stasis and relieving pain, providing a new direction for the external treatment strategy of traditional Chinese medicine for primary dysmenorrhea.

The application discloses a deer source extract and application thereof in preparation of a medicine for treating primary dysmenorrhea, and belongs to the technical field of medicines. The deer horn extract is prepared from deer horn through alkali extraction and acid precipitation, and is purified through molecular weight cut-off, and four P1-P4 deer horn polypeptides with specific amino acid sequences are obtained through further multi-dimensional activity screening. The deer horn polypeptide can play a synergistic effect on multiple targets through regulating uterine tissue prostaglandin balance, inhibiting abnormal contraction of uterine smooth muscle, reducing local inflammatory response, improving ischemia and hypoxia injury, and regulating pain signal transmission, and effectively improves symptoms such as spasm and pain of primary dysmenorrhea. The application also prepares various dosage forms such as tablets and capsules by taking the deer horn extract or the deer horn polypeptide as a main active ingredient, and can meet the needs of different scenes such as acute symptom relief and long-term periodic conditioning, has high safety, good patient compliance, and provides a safe and effective natural intervention scheme for primary dysmenorrhea.

A uterine tissue resection system may include a housing enclosing a power source such as a battery, a motor, and a control board for regulating power to the motor and the battery. Extending distally from the housing may be a cutting assembly comprising an outer cutting tube with an inner cutting tube received therein. The inner cutting tube may be fluidly coupled to an external suction source through a swivel connection interface. The housing may further contain a drive assembly connecting the inner cutting tube to a driveshaft of the motor so that rotation of the driveshaft results in simultaneous rotation and reciprocation of the inner cutting tube.

Robotic surgical systems and methods for using both laparoscopic and trans-cervical tools and imaging devices to resect fibroids or other abnormal uterine tissue.

This invention relates to the field of intelligent hysteroscopic imaging technology, specifically a method for image recognition and enhancement in hysteroscopic diagnosis of common intrauterine diseases. The method includes: synchronously acquiring a continuous stream of raw images and physical motion trajectories via hysteroscopy; performing spatiotemporal continuity analysis to generate a dynamic deformation mapping atlas; and identifying and marking areas of abnormal tissue compliance. Multiple virtual scanning windows are generated based on the contours of these abnormal areas. The image information entropy and expected feature abundance values ​​for each window are calculated, and an acquisition urgency level is assigned. An execution queue is constructed based on the urgency level and equipment physical constraints, driving the device to perform sequential pause-focusing scans to acquire high-resolution locally enhanced images. The local images are then feature-aligned and stitched with the raw image stream to synthesize an enhanced fusion diagnostic image covering the entire uterine cavity. This method can objectively assess the mechanical properties of uterine tissue and intelligently and adaptively allocate scanning resources, thereby improving the information content of the images and diagnostic efficiency.