388 results about "Sequela" patented technology

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.

The invention relates to a composite of active ingredients of Chinese herb medicine used for preventing the damage of cerebral ischemia and relevant diseases, in particular to a preparation which is prepared by the active ingredients of the Chinese herb medicine; the preparation is prepared by the active ingredients of the Chinese herb medicine and the conventional preparation technique which is used by carriers permitted by pharmacy, and comprises the following components with the parts by weight: 2 to 10 parts of ginsenoside Rb, 2 to 10 parts of ginsenoside Rg1, 1 to 5 parts of ginsenoside Rd, 1 to 5 parts of ginsenoside Re, 2 to 10 parts of stilbene glycoside, 1 to 5 parts of ginkgolide and 1 to 5 parts of flavonoid mixture which consists of kaempferol and quercetin with the weight rate to be 1:1. The invention has the advantages that the defects that in the traditional compounded Chinese medicine, the composition is complex, the product quality is not controlled effectively and the curative effect is not stable are overcome, has clear ingredients, definite effect, stable quality and obvious control effect on ischemic stroke, sequela, cerebral arteriosclerosis and vascular dementia, can improve the functions of motor nerve, and learning and memory of the patients, has low toxicity and simple preparation method without obvious side effect and is suitable for industrial mass production.

The invention discloses a medical combination for treating pulmonary heart disease and rheumatic heart disease and the preparation method thereof; the invention is prepared by peach kernel, safflower, angelica, charles abraham, Szechwan Lovage Rhizome, red peony root, achyranthes root, balloonflower root, bupleurum, citrus aurantium, and licorice. The medical combination of the invention has the efficacy of activating blood, promoting qi and ending pains, mainly for the treatment of pulmonary heart disease, rheumatic heart disease, the chest pain and headache caused by the clotted blood and the unsmooth blood flow in the chest, and also for coronary angina pectoris, chest contusion, rib chondritis chest pain, neurosis, deprementia of the concussion of brain sequela, dizziness headache, and other diseases. The invention has the advantages of simple formula, easy production, convenient taking by the patients, obvious efficacy, and wide application value.

The invention relates to a Chinese patient medicament for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The Chinese patient medicament is prepared from the following raw materials by weight: 0.3 gram of cornu saigae tatariace powder, 12 grams of tabasheer, 15 grams of grassleaf sweelflag rhizome, 15 grams of sea-ear shell, 10 grams of nacre, 15 grams of raw dragon bone and oyster shell, 12 grams of thinleaf milkwort root-bark, 12 grams of bamboo shavings, 20 grams of salivia chinensis, 15 grams of tall gastrodia tuber, 20 grams of gambir plant, 20 grams of common selfheal fruit-spike, 10 grams of radix geutianae, 20 grams of dendrobium, 30 grams of liquor white paeony root, 30 grams of vinegar white paeony root, 30 grams of raw white paeony root, 12 grams of radix curcumae, 15 grams of vinegar Chinese thorowax root, 15 grams of liquor rhubarb, 0.1 gram of musk, 12 grams of turtle shell, 15 grams of stiff silkworm, 20 grams of sanguisuga, 30 grams of earthworm, 25 grams of kudzuvine root, 10 grams of scorpion, 15 grams of desertliving cistanche, 6 grams of liquorice root, 100 grams of astragalus, 15 grams of szechwon tangshen root, 20 grams of heterophylly falsestarwort root, 15 grams of liquor Chinese angelica, 12 grams of szechuan lovage rhizome, 12 grams of safflower and the like. The Chinese patient medicament has the advantages of preventing the evolution period and sequelae of the cardiovascular and cerebrovascular diseases from generating and overcoming the defect that other treatment methods make patients generate medicinal tolerance to various medicaments.

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

RNA interference, is provided for inhibition of HIF1A mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.

The present invention provides preparation process of medicine for treating cerebral apoplexy and its sequela. The reasonable preparation process has classified extraction of Chinese medicine components in different properties, and the medicine has greatly raised effective component content and obviously reduced dosage.

The invention relates to a medicament for treating cardiovascular and cerebrovascular diseases and sequela of the same, which is prepared from the following raw Chinese medicaments in portion by weight: 120 to 140 portions of radix notoginseng, 100 to 120 portions of earthworm, 100 to 120 portions of leech, 120 to 150 portions of Astragalus membranaceus, 60 to 90 portions of Chuanxiong rhizome, 60 to 90 portions of safflower, 120 to 140 portions of peach kernel, 90 to 120 portions of red sage root and 110 to 130 portions of pearl. The medicament has simple formulation, consolidated treatment effect and easy preparation, is convenient for patients to take, can be used for treating the patients who are weak due to suffering from diseases for a long time and suffer from other diseases, and is particularly suitable for the patients who simultaneously have cardiovascular and cerebrovascular diseases.

The invention discloses a traditional Chinese medicine for treating apoplexy sequela, hypertension, hyperlipidemia and hyperviscosemia. The traditional Chinese medicine is prepared from the following bulk pharmaceutical chemicals as active ingredients in parts by weight: 100-120 parts of radix astragali seu hedysari, 10-15 parts of radix paeoniae rubra, 10-12 parts of herbs of false chinese swertia, 8-10 parts of rhizoma ligustici chuanxiong, 8-10 parts of semen persicae, 3-5 parts of flos carthami, 8-10 parts of lumbricus, 20-25 parts of radix salviae miltiorrhizae, 8-10 parts of hirudo, 10-15 parts of radix dipsaci, 12-15 parts of herba taxilli, 8-10 parts of cortex eucommiae, 28-30 parts of raw hawthorn, 4-5 parts of ramulus cinnamomi, 8-10 parts of bulbus allii macrostemonis, 12-15 parts of radix cyathulae, 18-20 parts of radix puerariae, 5-6 parts of scorpio, 28-30 parts of folium ginkgo, 25-30 parts of herba erigernotis, 8-10 parts of rhizoma alismatis, 28-30 parts of poria, 25-30 parts of semen ziziphi spinosae, 18-20 parts of semen cassiae, 18-20 parts of scorched medicated leaven and 10-15 parts of fructus ligustri lucidi. The traditional Chinese medicine can achieve the efficacies of invigorating qi and promoting blood circulation, promoting circulation and removing stasis, stimulating the menstruational flow and dissipating the phlegm, and tonifying the kidney and reducing the blood pressure, and is a first-choice medicament of the patients with apoplexy sequela, hypertension, hyperlipidemia and hyperviscosemia, and has obvious treatment effect.

An application of refined fur seal oil "OMEGA 3" in preparing the medicines for preventing and treating senile dementia and apoplexy sequela is disclosed. Said defined fur seal oil "OMEGA 3" contains octadecadienoic acid, octadecatrienoic acid, EPA, DPA, DHA, squalene, VE, unsaturated fatty acid, and saturated fatty acid.

The invention discloses a medicine for treating facioplegia, which is prepared by 18 Chinese herbal medicines such as Chang bamboo, monkshood, liquorice, angelic sinensis and the like and can be made into capsules, pills and plaster; and the medicine can quickly activate the nervous function of the face, has fast effect, high recovery rate, and non-recurrence without sequela, and is widely applied to the treatment of a plurality of diseases such facioplegia, prosopospasm, musculus facialis numbness, trigeminal neuralgia, etc.

The invention relates to a Chinese medicinal preparation for treating dental ulcer. The Chinese medicinal preparation is prepared by decocting the following bulk pharmaceuticals with the conventional traditional Chinese medicine decoction method in parts by weight: 10-30 parts of fructus gardeniae, 10-30 parts of honeysuckle flower, 5-30 parts of pseudo-ginseng root, 10-30 parts of coptis root, 10-20 parts of lightyellow sophora root, 5-20 parts of common lophatherum herb and 2-10 parts of borneol. The preparation has the characteristics of readily available raw materials which are Chinese medicinal herbs, no toxic or side effect, sequela resistance, unique action, easiness for preparing, good effect, quick response, remarkable curative effect, good pain relieving effect, quick healing action on ulcer, delayed relieving course and capability of regulating the immunologic function of a mechanism, can be used for basically healing dental ulcer within one week, can be used for truly achieving the effects of quick response and treatment of both principal and secondary aspects of a disease, and can be used for treating various dental ulcer diseases.

The invention relates to a medicament for treating skin disease of foot and insoles containing the medicament, wherein the medicament is prepared from the following raw materials (by weight portions): flavescent sophora root 21-28%, ledebouriella root 21-28%, rhizome of Sichuan lovage 21-28%, dahurian angelica root 12-14%, talcum powder 12-14%. The insole includes a skin layer and a sandwich layer.

The invention discloses a white clear cosmetic, comprising traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components include 1.5 to 2.5 parts by weight of radix notoginseng, 0.5 to 1.5 parts by weight of ginseng, 1.5 to 2.5 parts by weight of safflower and 0.5 to 1.5 parts by weight of pearl powder. The pure traditional Chinese medicine mask disclosed by the invention contains no chemical additive components, is nontoxic and harmless to human body, and has obvious effects on the sequela left by skin whitening, removing or fading of various stubborn taches noir, chloasma, sunburn and cyasma and skin changing.

A slow-releasing breviscapine B tablet for treating apoplexy sequela, palsy, cerebral thrombosis, coronary heart disease, angina pectoris, myocardial infarction, and rheumatalgia is prepared from breviscapine B, cellulose ether and/or cellulose ester or cross-linked polyacrylic resin, and assistant. Its advantage is high curative effect.

The present invention provides one kind of brain extract extracted from brain tissue of mammal, including pig, dog, ox, sheep, deer, horse and rabbit. The brain extract contains polypeptide, free lysine, free glutamic acid and total sugar in the weight ratio of 1-200 to 0.1-100 to 0.1-80 to 0.1-12, and has molecular weight of 5,000-10,000. The brain extract contains active matters capable of regulating and improving cerebral metabolism and may be used in treating cerebral vascular diseases and corresponding cerebral metabolic disturbance sequela.

The present invention provides persimmon leaf extract preparation, a preparing method thereof and application thereof. The persimmon leaf extract preparation comprises the following components: persimmon leaf extract dry paste of 20% to 50 %, dextrine of 10 % to 30%, starch of 20% to 40%, polyvinylpolypyrrolidone of 1% to 10%, sodium carboxymethyl starch of 1% to 10 % and Tween-800 of 1 % to 10%.In the preparing method, the persimmon leaf extract dry paste is mixed with various accessories, which can be pelletized by a wet method (water or ethanol with certain concentration is used as a wetting agent) to be preformed into tablet; or the persimmon leaf extract dry paste is mixed with various accessories to be directly preformed into the tablet in a dry method. The persimmon leaf extract preparation has better disintegration performance, and the disintegration time is shortened; even suspension can be formed; the drug biologic use degree is improved; and the persimmon leaf extract preparation is suitable for curing coronary heart disease, angina, cerebral arteriosclerosis, transient ischemic attacks, cerebral thrombosis sequela, senile dementia and the like.

The present invention relates to a Chinese medicine for effectively curing viral myocarditis and cardiomyopathy with excellent therapeutic effect. It is made up by using 16 Chinese medicinal materials of antelope horn, coptis root, codonopsis root, astragalus root, flavescent sophora root and others through a certain preparation process.

The invention discloses an anti-stroke pill for treating cerebral apoplex and the sequela thereof, which comprises the main drug ingredients based on weight parts: 80-140 of astragaloside, 6-20 of angelica, 6-30 of red paeony root, 6-20 of szechuan lovage rhizome, 6-20 of peach seed, 6-20 of safflower. The preparing method includes: extracting solvent with water and alcohol, adding concentrated alcohol to deposit protein, resin, and glycan, and then enriching flavone and glycoside of the drug liquor by a n-butylalcohol extraction method and a resin column separation method, wherein the content change is measured in each step, and finally carrying out quality standard test, stability test, and fingerprint test. The preparation of the invention is advanced, the quality is controlable and stable, the effect is defined. The pill of the invention is suitable for treating diseases of slobbering, slurred speech, limb numbness, enuresis, hemiplegia, or the like, caused by cerebral apoplex and the sequela thereof.

The invention discloses an acer truncatum seed oil nanometer microcapsule for middle-aged and elderly health-care eating, and a preparation method thereof. The preparation method comprises the following steps: by taking acer truncatum seed oil as a core material, octenyl succinic anhydride-modified gum arabic, octenyl succinic anhydride modified starch and oligosaccharide syrup as wall materials, and fatty acid monoglyceride and fatty acid biglyceride as a core material emulsifier, performing dynamic high-pressure microjetting, and spray drying to be powdery to obtain the acer truncatum seed oil nanometer microcapsule product. The prepared acer truncatum seed oil nanometer microcapsule is safe and non-toxic, low in cost, simple in preparation technology, and suitable for large-scale production. Furthermore, the acer truncatum seed oil nanometer microcapsule is rich in nervonic acid and alpha-linolenic acid, thus having the functions of reducing blood fat and blood pressure, inhibiting senile dementia and parkinson's disease, improving sequela of cerebral apoplexy and hypomnesis, prolonging aging and the like. In addition, the acer truncatum seed oil nanometer microcapsule is a nanometer microcapsule product, and the bioavailability of nutritional substances in the acer truncatum seed oil can be effectively improved through the absorption of nanoparticles.

The invention provides a drug, namely ginkgo biloba general vein medicine for treating a cardiovascular disease. The drug is prepared from the following components in parts by weight of 300-400 parts of ginkgo leaf, 30-80 parts of pseudo-ginseng, 300-400 parts of root of red-rooted salvia, 100-200 parts of ligusticum wallichii, and 100-200 parts of astragalus mongholicus. The drug has the effects of invigorating bolt elimination, regulating qi to alleviate pain, expanding coronary or cerebral arteries, restricting platelet aggregation, reducing blood fat and blood viscosity, and the like. The drug is used for treating coronary heart disease, stenocardia, myocardial infarction, cerebral arteriosclerosis, hyperlipidemia, apoplexy (apoplexia) and sequelae thereof; and furthermore, the drug also has good analgesic anti-inflammatory effects. The drug has significant curative effects on the cardiovascular disease, thoracic obstruction caused by qi-stagnation and blood stasis, namely coronary heart disease angina, giddiness namely cerebral arteriosclerosis and the like, is rapid to recover after being taken, low in recurrence rate, high in security, free of side effect, simple and convenient to prepare, and the like.

The invention discloses a Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and a preparation process of products thereof. The preparation process comprises the following steps of: decocting Chinese angelica, chuanxiong rhizome, safflower, salvia miltiorrhiza, American ginseng, notoginseng, tree peony bark, earthworms, leech and gradfly; filtering; adding Zygosaccharomyces bailii to the resulting filtrate and filter residues, standing to culture in appropriate temperature and humidity environments for 168 to 240 hours, and making oral liquids, oral tablets or capsules. The main indications of the product disclosed by the invention include cardiovascular and cerebrovascular diseases, hypertension and blood diseases, and the product is directly taken, has rapid onset of action, prevents the recurrence of diseases, is absorbed rapidly, has high curative effects, is sweet in taste, and cause no sequela or complication after administration. By applying microorganisms to Chinese medicines, the two special processes of solid fermentation and liquid fermentation are achieved, so as to eliminate the toxic and adverse effects of active pharmaceutical ingredients, provide convenience for storage and administration and not produce wastes or residues. Besides, the resources of raw materials are abundant, the production is simple and low in cost, and the product is applied to both therapy and health care.

The present invention belongs to a Chinese traditional medicine preparation in medical preparation product for curing sequela of cerebral paralysis; the preparation is made of the following raw materials of Chinese traditional medicines with corresponding weight portions of 6 portion to 12 portion of zhinanxing, 6 portion to 12 portion of pinellia tuber, 4 portion to 8 portion of giant typhonium tuber, 10 portion to 20 portion of chuanxiong rhizome, 6 portion to 12 portion of body of Buthus martensii, 15 portion to 25 portion of earthworm, 10 portion to 20 portion of tall gastrodia tuber, 15 portion to 25 portion of clematis, 10 portion to 20 portion of white caltrop, 40 portion to 60 portion of milk vetch roots, 10 portion to 20 portion of magnolia officinalis, 15 portion to 25 portion of trifoliate orange fruit, 15 portion to 25 portion of roots of red salvia, 10 portion to 20 portion of flagleaf, 15 portion to 25 portion of Tuckahoe, 15 portion to 25 portion of milkwort roots, 15 portion to 25 portion of codonopsis pilosula, 5 portion to 7 portion of safflowers, 10 portion to 20 portion of ledeboruiella root, 10 portion to 20 portion of myrrh, 7 portion to 11 portion of gynura segetum and 15 portion to 20 portion of sapanwood. The present invention of the preparation contains active components which can stimulate the impaired brain cells and recover the function of the cells through blood-brain barrier; at the same time, the preparation can repair the impaired nerves and recover the impaired blood-brain barrier to protect the brain tissue and improve the nerve function of patients; the preparation can promote the absorption of encephalic hematoma and reduce the disability rate; in this way, people can recover normal living and working capability and the present invention is a good medicine for curing sequela of cerebral paralysis.

The present invention relates to a series of closed operation accupotome, including 12 types of accupotome with 33 models, each type of accupotome having an accupotome handle, an accupotome body and an accupotome head, which are connected in this order. It is characterized in that the handle, the body or the head may have various shapes depending on various diseases, and that the flat surface of the handle and the flat wedged surface of the head are in the same plane. The advantages of this invention are: entering into human body without cutting skin, to make the open surgery treatment turn into a closed surgery, and to make chemical therapy turn into physical therapy. Thus, it avoids sequelae and complications brought by the open surgery, and adverse reactions caused by the chemical medications. In addition, it improves curative effects, shortens course of diseases, simplifies therapeutic process, and saves a lot of medical expenses.