61 results about "Sequela" patented technology

The invention discloses a method for training a stroke recurrence risk prediction model and a related product. The method comprises the following steps: acquiring cerebral perfusion image data, clinical data and follow-up visit data of a patient; the follow-up visit data comprises follow-up visit time and a survival state of the follow-up visit time; the survival state comprises whether stroke relapse occurs or not, whether sequelae exists or not, whether complications exist or not and whether death exists or not; data integration is carried out on the follow-up time and the survival state of the follow-up time to obtain at least one survival time-event indication pair, the event indication is used for identifying whether a preset event occurs in the survival time, and the preset event is stroke relapse; and inputting the brain perfusion image data, the clinical data, the follow-up visit data and the at least one survival time-event indication pair into the stroke recurrence risk prediction model as training data to train the stroke recurrence risk prediction model. By using the scheme disclosed by the invention, the prediction precision of the stroke recurrence risk can be improved.

Provided are compositions and method for prophylaxis and / or therapy of hearing loss or related dysfunctions, including but not limited to tinnitus, that could be ameliorated by restoring central nervous system inhibitory synapses. The compositions include polynucleotides and viral vectors that are used to express at least one GABA receptor component which may be a GABAA receptor alpha 1 subunit or GABAR receptor Ib subunit. Expression of the GABA receptor may be under control of a CaMKII promoter.

The present disclosure provides a method for treating post-acute sequelae of severe acute respiratory syndrome (SARS)-CoV-2 infection (PASC) or one or more symptoms associated with said PASC, said method comprising administering to a subject in need thereof or at risk thereof a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The present disclosure provides, in some embodiments, a method and a pharmaceutical composition for treating post-acute sequelae of (SARS)-CoV-2 infection (PASC) or one or more symptoms associated therewith in a subject in need thereof or at risk thereof, wherein said pharmaceutical composition comprises a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

A food and medicine component composition, a food and medicine compound medicament, and a preparation method of a food and medicine compound medicament and use thereof are provided. The food and medicine component composition includes 0.5 to 1.5 parts by weight of Red Peony Root; 0.5 to 1.5 parts by weight of Chuanxiong Rhizome; 10 to 15 parts by weight of Hedysarum Root; and 50 to 55 parts by weight of whole raw fish. The food and medicine compound medicament is prepared by the following preparation method: placing the above food and medicine component composition in water, and heating for decoction to obtain the food and medicine compound medicament. The food and medicine compound medicament prepared from the above food and medicine component composition can be used for preparing a drug for treating acute central nervous system injury or a sequela of acute central nervous system injury.

Embodiments of therapeutic protocols to treat Post-Acute Sequelae SARS-CoV-2 infection (“PASC”), a.k.a. “long Covid,” are described. The PASC treatment protocols focus on a moderating a hyperimmune response; destroying and removing the SARS CoV-2 spike protein from the gut and body, detoxifying the body and the brain; replenishing key nutrients; mitigating depression and anxiety; and a regimen of physical and mental exercises. A standard six-week protocol and a shorter, three-week protocol are disclosed for those with a milder form of PASC are disclosed.

This application relates to the technical field of exosome preparation, specifically disclosing a pharmaceutical component for the prevention and treatment of sequelae of cerebral thrombosis, its preparation method, and its application. The pharmaceutical component comprises Exo-miR-17-92 and Exo-miR-30d-5p; it is obtained by secretion from mesenchymal stem cells capable of simultaneously overexpressing the genes miR-17-92 and miR-30d-5p; the sequence of the gene miR-17-92 is shown in SEQ ID NO:1, and the sequence of the gene miR-30d-5p is shown in SEQ ID NO:2. The pharmaceutical component of this application, comprising Exo-miR-17-92 and Exo-miR-30d-5p, exerts a significant and excellent therapeutic effect on sequelae of cerebral thrombosis through the synergistic effect of their expression products.

The invention discloses a preparation for treating facial paralysis and a preparation and use method thereof, and belongs to the technical field of traditional Chinese medicines. The preparation is prepared from radix angelicae, rhizoma typhonii, mint and fructus gleditsiae. The prescription has the treatment rules of expelling wind and removing cold, clearing and activating the channels and collaterals, and restoring consciousness and opening orifices. The traditional Chinese medicine essence is adopted for expelling wind and removing cold, clearing and activating the channels and collaterals and relieving oppressed facial nerves, so that the curing purpose is achieved. Through clinical experience for many years, the product has a unique treatment effect on the facial paralysis field, a just obtained patient can be cured in one treatment course, the cure rate is 99% or above, a sequelae patient can be cured to 90% or above in three treatment courses, and the effects of expelling wind, removing cold, clearing and activating the channels and collaterals are achieved.

To provide broad spectrum molecules with the capability of binding specifically to and inhibiting TLR-4 and that are useful as therapeutic agents against a broad range of diseases and conditions related to the overexpression or overactivation of TLR-4.SOLUTION: Provided is an aptamer for use in ameliorating or improving at least a symptom or sequelae of acute cardiac infarction, the aptamer having a length between 40 and 100 nucleotides and being selected from a specific sequence group, and (i) the aptamer specifically binding to an epitope on the extracellular domain of TLR-4, (ii) binding of the aptamer to the epitope reducing and / or inhibiting TLR-4 activation, and the aptamer being administered during, prior, or immediately after the acute cardiac infarction.SELECTED DRAWING: None

Compositions and methods are presented that, upon administration prior to trauma, are effective to prevent and / or reduce severity of sequelae of TBI upon trauma. Advantageously, the compositions presented herein can be orally administered, have an excellent safety profile, and will not require a prescription by physician or hospital admission. Further contemplated compositions and methods are presented to be effective to prevent and / or reduce severity of sequelae of glutamate excitotoxicity.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention relates to a construction method of an infectious disease patient sequelae risk prediction model. The method comprises the following steps: determining all associated indexes of infectious disease patient sequelae risk prediction; determining weight values of all the associated indexes, and selecting the associated indexes of which the ranking of the weight values is higher than a ranking threshold value from all the associated indexes as prediction index data; carrying out infectious disease patient sampling based on the prediction index data to obtain a sampling data set, wherein the infectious disease patient sampling refers to sampling of patients with sequelae and patients without sequelae in infectious disease patients; obtaining prediction index data of a to-be-predicted infectious disease patient; and performing sequelae risk prediction on the prediction index data of the to-be-predicted infectious disease patient based on the sampling data set to obtain a sequelae risk prediction result. According to the mode provided by the invention, on one hand, a patient can be prevented from frequently going to a hospital to see a doctor so as to save time cost of a user, and on the other hand, the calculated sequelae risk prediction result is more comprehensive and accurate.

The invention discloses an application of cooperation of a chairsi acupoint and acupuncture in facial paralysis catgut embedding intervention, relates to the technical field of traditional Chinese medicine acupuncture treatment, and aims at solving the problems that in existing facial paralysis treatment, the acupuncture stimulation time is short, catgut embedding is mostly suitable for the late stage, hormone dependence is caused, and the sequelae risk is high. According to the application, early-stage facial paralysis patients are screened, facial local acupoint acupuncture is firstly carried out to quickly relieve symptoms, then far-end acupoints of the board Qi acupoints are selected, medical catgut is adopted for acupoint catgut embedding, and the synergistic effect of short-term acupuncture intervention and long-acting catgut embedding stimulation is achieved. Clinical tests prove that the synergistic application can significantly prolong the acupoint stimulation duration, regulate channel qi, stimulate healthy qi, effectively improve the facial nerve function and body and social life functions (facial disability index score) of a patient, shorten the treatment course, reduce the hormone use amount and use time, and reduce the occurrence probability of intractable facial paralysis. The catgut is free of toxic and side effects, convenient to operate and high in patient compliance, a novel traditional Chinese medicine suitable technology is provided for early intervention of facial paralysis, social and economic benefits are remarkable, and the catgut is suitable for clinical popularization.

The present disclosure features modulating (e.g., agonizing) an apelin receptor (also referred to herein as an APJ receptor; in particular, the present invention relates to chemical entities (e.g., compounds or pharmaceutically acceptable salts and / or hydrates of compounds and / or prodrugs of compounds) that have a molecular marker APLNR (e.g., a gene symbol APLNR). The disclosure also features compositions comprising the chemical entities, as well as other methods of use and preparation. The chemical entities are useful, for example, in the treatment of a subject (e.g., a human) having a disease, disorder or condition in which APJ receptor activity is reduced (e.g., APJ receptor signaling is hindered or impaired; e.g., apelin-APJ receptor signaling is hindered or impaired) or down-regulation of endogenous apelin contributes to the pathology and / or symptom and / or progression of the disease, disorder or condition. Non-limiting examples of these diseases, disorders or conditions include: (i) cardiovascular disease; (ii) a metabolic disorder; (iii) diseases, conditions and conditions associated with vasopathology; (iv) organ failure; (v) diseases, disorders, and conditions associated with infection (e.g., microbial infection); (vi) a disease, disorder or condition of a sequelae or complication of any of the foregoing or disclosed herein. More specific non-limiting examples of these diseases, disorders or conditions include pulmonary arterial hypertension (e.g., PAH); heart failure; type II diabetes; renal failure; , sepsis and systemic hypertension.

The system and terminal equipment for disease detection based on physiological parameters, the system comprises: a terminal equipment and a wearable device. Based on the physiological data collected by the wearable device worn by the user daily, the terminal equipment processes the data after obtaining the data, compares the differences between the physiological data of the day and the personal baseline data of the user, monitors the risk of the user's illness of the day every day, obtains the monitoring result of each day and shows it to the user, for example, including: the probability of illness of the day, the risk level of the day, whether there is an abnormality of each physiological parameter of the day, etc. Moreover, combined with the historical monitoring results and historical physiological data, according to the differences of the physiological data of the user before and after the disease, whether there is a long-term sequelae after the recovery of the disease is informed to the user, the long-term trend analysis of the health of the user is realized. Thus, both the current disease risk of the user and the long-term trend analysis of the health of the user are monitored, so as to better provide the health guidance service for the user.

The invention discloses a comprehensive medicine bag for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae and a preparation method thereof, and belongs to the technical field of comprehensive medicine bags, the medicine bag is prepared from the following raw materials in parts by weight: 1 part of white flower, 1 part of red bud flower, 1 part of sambucus williamsii, 1 part of cinnamomum camphora, 1 part of hematoxylon, 1 part of Chinese sausage leaves, 1 part of ruellia tenuifolia and 1 part of folium artemisiae argyi. The preparation method comprises the following steps: grinding fresh leaf branches or dry leaf branches of flos lonicerae, red bud flowers, sambucus williamsii, cinnamomum camphora, hematoxylon, folium saussureae leaves, ruellia tenuifolia and folium artemisiae argyi into coarse powder, and then fumigating the medicinal materials at 105 DEG C for 10-20 minutes to obtain the product. The formula can be used for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae. The traditional Chinese medicine composition has the effects of removing wind, promoting blood circulation, relieving pain, tonifying fire, strengthening the body, diminishing swelling, promoting reunion of fractured tendons and bones, treating wind-cold-dampness arthralgia, waist and knee icy pain, cold impotence, various headache symptoms, limb joint spasm and dramatic pain, menstrual disorder, dysmenorrhea, amenorrhea, puerperal fever, clearing away heat and toxic materials, rheumatism limb joint swelling and pain, traumatic injury, rheumatism arthralgia and myalgia, edema, postpartum anemic fainting, hernia pain, stomachache, rheumatism leg pain and kidney deficiency nephritis. The traditional Chinese medicine composition has the effects of treating postpartum lumbago and thoracoabdominal stabbing pain, promoting blood circulation to treat wounds, clearing and activating the channels and collaterals, regulating blood vessels, improving liver functions, resisting oxidation, promoting digestion, relieving constipation, reducing blood pressure, controlling blood sugar, protecting the liver, beautifying the skin, resisting bacteria and diminishing inflammation, and well improving acnes, comedos and oily skin.

Provided herein are methods and pharmaceutical compositions for preventing or reducing frequency or severity of convulsions or seizures, particularly epileptic seizures by administration of a therapeutically effective amount of 2-deoxy-D-glucose (2-DG) in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones. Also provided are methods and pharmaceutical compositions for reducing severity and progression of traumatic brain injury and deleterious sequelae resulting therefrom in an animal by administration of a therapeutically effective amount of 2-DG in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones.

The present invention discloses a Traditional Chinese Medicine (TCM) splint external fixation device, comprising five dorsal splints, five radial splints, five volar splints, and an ulnar splint for use when the wrist joint is in the neutral, dorsiflexion, flexion, functional, and support positions, respectively. The TCM splint external fixation device of the present invention can adapt to changes in wrist fracture classification and staging. It has a modular structure, is simple and quick to use, can improve the comfort of fracture external fixation treatment, and can reduce the occurrence of sequelae such as joint stiffness in the later stages.

Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The systems and methods include applying an electrical impulse transcutaneously through the outer skin surface of the patient to a cervical branch of the vagus nerve of the patient. The electrical impulse is sufficient to reduce a number of antibodies associated with blood clotting to reduce a level of blood clotting in the patient. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

The present invention discloses a biological acetabular partial reconstruction prosthesis for treating hip dysplasia, which comprises a specific base and an articular surface coating. The upper end of the specific base is pointed and small, while the lower end is thick and large. It includes an acetabular contact surface, a soft tissue contact surface and a femoral head joint engagement surface. The acetabular contact surface and the soft tissue contact surface enclose the side surface of the specific base, and the femoral head joint engagement surface constitutes the bottom surface of the specific base. The specific base is a three-dimensional porous network structure. The biological acetabular partial reconstruction prosthesis for treating hip dysplasia disclosed by the present invention enables patients to improve the biomechanical environment of the hip joint, delay the progression of hip arthritis, and avoid the disadvantages of large surgical trauma and poor morphological combination of the existing periacetabular osteotomy. At the same time, it can be applied to the early treatment of sequelae of hip dysplasia, delay or avoid joint replacement, and has a significant effect on the treatment of patients with mild hip dysplasia.

The present disclosure provides methods for treating post acute sequelae (PASC) of severe acute respiratory syndrome (SARS)-CoV-2 infection, or one or more symptoms associated with PASC, comprising administering a pharmaceutical composition to a subject in need thereof or at risk thereof, the pharmaceutical composition comprises a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

A system and method operates for diagnosis of mild traumatic brain injury (mTBI) to prevent sequelae and improve neurocognitive outcomes. The system may have a processor that receives, from a magnetic resonance imaging machine, data corresponding to magnetic resonance imaging images. By using a machine learning classifier of the processor, such as a Bayesian machine learning classifier, the processor identifies mild traumatic brain injury in a person through cortico-cortical connectome mapping from magnetic resonance imaging. The processor can also generate a human readable screen display indicative of the identified mild traumatic brain injury.

The invention discloses a traditional Chinese medicine composition for treating Bell paralysis sequelae. The traditional Chinese medicine composition is prepared from the following raw material medicines: astragalus membranaceus, angelica sinensis, radix rehmanniae preparata, ligusticum wallichii, parched white peony root, kudzu vine root, cortex albiziae, pawpaw, semen coicis, lycopodium clavatum, caulis spatholobi and angelica dahurica. The invention further discloses a traditional Chinese medicine compound preparation for treating the Bell paralysis sequelae and application of the traditional Chinese medicine composition or the traditional Chinese medicine compound preparation to preparation of medicine for treating the Bell paralysis sequelae. The traditional Chinese medicine composition has a remarkable curative effect on Bell facial paralysis sequelae such as mouth-eye linkage, facial spasm and facial muscle tension and weakness, can remarkably relieve facial tension, relieve mouth-eye linkage, relieve facial spasm and improve the living quality and mental state of a patient, is remarkable in treatment effect, can adjust and add or reduce the formula according to specific diseases, and is free of toxic and side effects. The method has great popularization and application values.

The devices and methods of the present invention can be used to capture and remove COVID-19 mediating nanoparticles and / or exosomes associated with COVID-19 or similar disease from the circulatory system of patients in need thereof, including those with post-COVID-19 syndrome or similar post-disease sequelae so-called “long haul” symptoms of COVID-19 or similar disease. The present invention benefits patients by providing lectin based extracorporeal methods for binding and physically removing SARS-C7oV-2 virions, or fragments thereof, from the circulatory system. Also provided are lectin based extracorporeal methods of binding and physically removing non-viral COVID-19 mediating nanoparticles. Also disclosed herein are devices and methods for reducing the levels of biomarkers and markers of morbidity / mortality of diseases such as COVID-19 and similar diseases, including cytokines, such as IL-6, Troponin T, and D-dimer.

Embodiments of therapeutic protocols to treat Post-Acute Sequelae SARS-COV-2 infection (“PASC”), a.k.a. “long Covid,” are described. The PASC treatment protocols focus on a moderating a hyperimmune response; destroying and removing the SARS COV-2 spike protein from the gut and body, detoxifying the body and the brain; replenishing key nutrients; mitigating depression and anxiety; and a regimen of physical and mental exercises. A standard six-week protocol and a shorter, three-week protocol are disclosed for those with a milder form of PASC are disclosed.

The present invention relates to a local blood flow shield for the aortic wall, belonging to the technical field of medical surgical instruments. The shield consists of two rods that are cross-hinged to each other and are divided into a pair of rod arms and a pair of rod handles that can be opened and closed relative to each other with the hinge point as the boundary. A chuck is provided at the end of one rod arm; a hood is provided at the end of the other rod arm, and a slidable sleeve is sleeved on the rod arm below the hood; the hood is composed of a telescopic skeleton and a diaphragm covering the skeleton; when the sleeve slides up or down along the other rod arm, it respectively sleeves the skeleton to make the hood form a contracted state or an expanded state; during the operation, when the pair of rod arms are closed and the hood is in the expanded state, the hood and the chuck respectively adhere to the inner surface and the outer surface of the local aortic wall and are opposed to each other. The shield can create a local bloodless surgical field through the enclosed three-dimensional space formed by the hood and the inner surface of the local aortic wall, and at the same time eliminate the sequelae caused by conventional clamping of the aortic wall.

The composition comprises the following raw materials: pinellia ternate, poria cocos, leech, scorpion, bamboo shavings, ginseng, radix angelicae pubescentis, notopterygium root, safflower, ligusticum wallichii, radix paeoniae alba, gastrodia elata, immature bitter orange, arisaema cum bile and musk, can expand blood vessels, enables blood flow to be smoother, and has the effects of promoting blood circulation and removing blood stasis. The blood in the body of the patient flows smoothly through the medicine, so that the sequelae can be effectively treated; stasis dredging, yang reviving and desertion consolidation are helped to be achieved; and various functions in the body are balanced.