19 results about "Sequela" patented technology

Embodiments of therapeutic protocols to treat Post-Acute Sequelae SARS-CoV-2 infection (“PASC”), a.k.a. “long Covid,” are described. The PASC treatment protocols focus on a moderating a hyperimmune response; destroying and removing the SARS CoV-2 spike protein from the gut and body, detoxifying the body and the brain; replenishing key nutrients; mitigating depression and anxiety; and a regimen of physical and mental exercises. A standard six-week protocol and a shorter, three-week protocol are disclosed for those with a milder form of PASC are disclosed.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

The invention discloses an application of cooperation of a chairsi acupoint and acupuncture in facial paralysis catgut embedding intervention, relates to the technical field of traditional Chinese medicine acupuncture treatment, and aims at solving the problems that in existing facial paralysis treatment, the acupuncture stimulation time is short, catgut embedding is mostly suitable for the late stage, hormone dependence is caused, and the sequelae risk is high. According to the application, early-stage facial paralysis patients are screened, facial local acupoint acupuncture is firstly carried out to quickly relieve symptoms, then far-end acupoints of the board Qi acupoints are selected, medical catgut is adopted for acupoint catgut embedding, and the synergistic effect of short-term acupuncture intervention and long-acting catgut embedding stimulation is achieved. Clinical tests prove that the synergistic application can significantly prolong the acupoint stimulation duration, regulate channel qi, stimulate healthy qi, effectively improve the facial nerve function and body and social life functions (facial disability index score) of a patient, shorten the treatment course, reduce the hormone use amount and use time, and reduce the occurrence probability of intractable facial paralysis. The catgut is free of toxic and side effects, convenient to operate and high in patient compliance, a novel traditional Chinese medicine suitable technology is provided for early intervention of facial paralysis, social and economic benefits are remarkable, and the catgut is suitable for clinical popularization.

The system and terminal equipment for disease detection based on physiological parameters, the system comprises: a terminal equipment and a wearable device. Based on the physiological data collected by the wearable device worn by the user daily, the terminal equipment processes the data after obtaining the data, compares the differences between the physiological data of the day and the personal baseline data of the user, monitors the risk of the user's illness of the day every day, obtains the monitoring result of each day and shows it to the user, for example, including: the probability of illness of the day, the risk level of the day, whether there is an abnormality of each physiological parameter of the day, etc. Moreover, combined with the historical monitoring results and historical physiological data, according to the differences of the physiological data of the user before and after the disease, whether there is a long-term sequelae after the recovery of the disease is informed to the user, the long-term trend analysis of the health of the user is realized. Thus, both the current disease risk of the user and the long-term trend analysis of the health of the user are monitored, so as to better provide the health guidance service for the user.

The invention discloses a comprehensive medicine bag for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae and a preparation method thereof, and belongs to the technical field of comprehensive medicine bags, the medicine bag is prepared from the following raw materials in parts by weight: 1 part of white flower, 1 part of red bud flower, 1 part of sambucus williamsii, 1 part of cinnamomum camphora, 1 part of hematoxylon, 1 part of Chinese sausage leaves, 1 part of ruellia tenuifolia and 1 part of folium artemisiae argyi. The preparation method comprises the following steps: grinding fresh leaf branches or dry leaf branches of flos lonicerae, red bud flowers, sambucus williamsii, cinnamomum camphora, hematoxylon, folium saussureae leaves, ruellia tenuifolia and folium artemisiae argyi into coarse powder, and then fumigating the medicinal materials at 105 DEG C for 10-20 minutes to obtain the product. The formula can be used for treating traumatic injuries, rheumatism bone diseases and postpartum sequelae. The traditional Chinese medicine composition has the effects of removing wind, promoting blood circulation, relieving pain, tonifying fire, strengthening the body, diminishing swelling, promoting reunion of fractured tendons and bones, treating wind-cold-dampness arthralgia, waist and knee icy pain, cold impotence, various headache symptoms, limb joint spasm and dramatic pain, menstrual disorder, dysmenorrhea, amenorrhea, puerperal fever, clearing away heat and toxic materials, rheumatism limb joint swelling and pain, traumatic injury, rheumatism arthralgia and myalgia, edema, postpartum anemic fainting, hernia pain, stomachache, rheumatism leg pain and kidney deficiency nephritis. The traditional Chinese medicine composition has the effects of treating postpartum lumbago and thoracoabdominal stabbing pain, promoting blood circulation to treat wounds, clearing and activating the channels and collaterals, regulating blood vessels, improving liver functions, resisting oxidation, promoting digestion, relieving constipation, reducing blood pressure, controlling blood sugar, protecting the liver, beautifying the skin, resisting bacteria and diminishing inflammation, and well improving acnes, comedos and oily skin.

Provided herein are methods and pharmaceutical compositions for preventing or reducing frequency or severity of convulsions or seizures, particularly epileptic seizures by administration of a therapeutically effective amount of 2-deoxy-D-glucose (2-DG) in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones. Also provided are methods and pharmaceutical compositions for reducing severity and progression of traumatic brain injury and deleterious sequelae resulting therefrom in an animal by administration of a therapeutically effective amount of 2-DG in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones.

Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The systems and methods include applying an electrical impulse transcutaneously through the outer skin surface of the patient to a cervical branch of the vagus nerve of the patient. The electrical impulse is sufficient to reduce a number of antibodies associated with blood clotting to reduce a level of blood clotting in the patient. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

The invention discloses a traditional Chinese medicine composition for treating Bell paralysis sequelae. The traditional Chinese medicine composition is prepared from the following raw material medicines: astragalus membranaceus, angelica sinensis, radix rehmanniae preparata, ligusticum wallichii, parched white peony root, kudzu vine root, cortex albiziae, pawpaw, semen coicis, lycopodium clavatum, caulis spatholobi and angelica dahurica. The invention further discloses a traditional Chinese medicine compound preparation for treating the Bell paralysis sequelae and application of the traditional Chinese medicine composition or the traditional Chinese medicine compound preparation to preparation of medicine for treating the Bell paralysis sequelae. The traditional Chinese medicine composition has a remarkable curative effect on Bell facial paralysis sequelae such as mouth-eye linkage, facial spasm and facial muscle tension and weakness, can remarkably relieve facial tension, relieve mouth-eye linkage, relieve facial spasm and improve the living quality and mental state of a patient, is remarkable in treatment effect, can adjust and add or reduce the formula according to specific diseases, and is free of toxic and side effects. The method has great popularization and application values.

Embodiments of therapeutic protocols to treat Post-Acute Sequelae SARS-COV-2 infection (“PASC”), a.k.a. “long Covid,” are described. The PASC treatment protocols focus on a moderating a hyperimmune response; destroying and removing the SARS COV-2 spike protein from the gut and body, detoxifying the body and the brain; replenishing key nutrients; mitigating depression and anxiety; and a regimen of physical and mental exercises. A standard six-week protocol and a shorter, three-week protocol are disclosed for those with a milder form of PASC are disclosed.

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and / or hydrate and / or prodrug of the compound) that that generates cross-linking in the cornea in response to exposure to an electromagnetic irradiation. This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which in which abnormal shaping of the cornea (e.g., thinning of the cornea, e.g., bilateral thinning of the cornea, e.g., bilateral thinning of the central, paracentral, or peripheral cornea; or steepening (e.g., bulging) of the cornea) contributes to the pathology and / or symptoms and / or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) corneal ectatic disorders; (ii) vision conditions; and (iii) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include keratoconus, keratoglobus, pellucid marginal degeneration, corneal ectasia (e.g., post-operative ectasia, e.g., post-LASIK ectasia), Terrien's marginal degeneration, myopia, hyperopia, astigmatism, irregular astigmatism, and presbyopia.

The invention relates to a medicine for treating cerebral thrombosis, cerebral thrombosis precursor and cerebral thrombosis sequelae. Comprising the following raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-20 parts of ligusticum wallichii, 10-20 parts of radix paeoniae rubra, 10-20 parts of gastrodia elata, 2-5 parts of scorpion, 10-20 parts of pseudo-ginseng, 10-20 parts of rhizoma corydalis, 10-20 parts of radix clematidis, 10-20 parts of earthworm, 10-20 parts of honeysuckle stem, 10-20 parts of ginkgo leaf, 1-3 parts of centipede, 10-20 parts of cassia twig, 2-5 parts of leech and 10-20 parts of herba siegesbeckiae. The traditional Chinese medicine is orally taken and externally applied, and has the effects of dispersing blood stasis, relieving spasm, activating blood, relieving pain, tonifying qi and nourishing blood.

A playful and therapeutic device for the rehabilitation of fine manual motor skills; specifically for the rehabilitation of patients with rheumatic, traumatic and neurological pathologies who have fine motor sequelae in the wrist, palm and fingers of both hands; characterized by having a cultural theme related to the Guelaguetza of Oaxaca and by comprising a container with a lid and handle that will serve to store and transport other components such as a puzzle, cylindrical pieces with and without slots, cards and tweezers.The device facilitates playful and therapeutic activities for mental, sensory, and physical stimulation; such as placing and removing the lid of the container to perform pronation and supination movements and palmar grasp; assembling a puzzle to perform pronation and supination movements, palmar grasp, four-finger pinch, and visuo-manual coordination; fitting cylinders into holes to perform two-finger pinch, three-finger pinch, and visuo-manual coordination movements; inserting cards into slots to perform pronation and supination movements, two-finger pinch, and visuo-manual coordination; and hooking tweezers onto a surface to perform pronation and supination movements, two-finger pinch, and visuo-manual coordination.

The invention discloses a head cover for brain nerve rehabilitation and a medicine formula of the head cover, relates to the technical field of neurological rehabilitation medical instruments, and aims to solve the problems that existing brain rehabilitation equipment is single in intervention mode, lacks a function and nutrition synergistic effect and is insufficient in adaptability and safety. The head cover comprises a wearing main body, a collaborative intervention system and an intelligent control module, the collaborative intervention system can synchronously output a plant source affinity electric signal and a Chinese herbal medicine essence containing a penetration enhancer, so that double intervention of signal regulation and nutrition nourishing is realized; the intelligent control module pre-stores customized intervention parameters of various brain diseases and can call corresponding programs according to target diseases. The rehabilitation efficiency is improved through a synergistic mechanism, the rehabilitation device is suitable for multiple diseases such as apoplexy sequela, Parkinson's disease and nervous headache, multiple safety monitoring design is achieved, and the household and clinical auxiliary rehabilitation requirements are met.

The present invention discloses phenyl-substituted dihydronaphthyridine compounds a preparation therefor and a use thereof, and belongs to the technical field of medicine. The compounds disclosed in the present invention are represented by formula I, and can be used as a mineralocorticoid receptor antagonist for treating, preventing or alleviating aldosteronism hyperplasia, diabetic nephropathy, hypertension, heart failure (comprising chronic heart failure, etc.), sequelae of myocardial infarction, liver cirrhosis, renal failure, stroke and other diseases in patients.

Systems, methods and apparatus are provided through which in some implementations, a system calculates an indication of cranial-concussion or sequelae from a cranial-concussion of a subject using skeletal tracking and calculating joint angles at different time points from the motion, posture, jumping / landing mechanics and / or balance of the subject in different movements.

Provided herein are methods and pharmaceutical compositions for preventing or reducing frequency or severity of convulsions or seizures, particularly epileptic seizures by administration of a therapeutically effective amount of 2-deoxy-D-glucose (2-DG) in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones. Also provided are methods and pharmaceutical compositions for reducing severity and progression of traumatic brain injury and deleterious sequelae resulting therefrom in an animal by administration of a therapeutically effective amount of 2-DG in combination with a therapeutically effective amount of beta-hydroxybutyrate, or 2-DG with other ketones or metabolic intermediates that increase brain ketones.

According to the CDC, the same month (March, 2020) they declared COVD-19 a pandemic, nearly 25% of confirmed COVID-19 hospitalized patients required intubation, or ventilator use. More recently, in the US, during the summer of 2021, child intubations more than quadrupled, when the Delta variant predominated.As Omicron and additional COVID-19 variants continue to arise globally, there will be an increasing number of sudden spikes in critical illness and respiratory failure. Preparedness with efficacious airway tools that optimize success rate of intubations is critical.Without the proper tools, intubation procedures take excessive time, and can fail entirely, causing diminished central nervous system oxygenation and potentially permanent neurologic sequelae. Airway adjuncts such as the Tracheal Introducer Sheath (TIS) and Simplified Tracheal Introducer Sheath (STIS) hold immense potential to improve chances of successful intubations.The TIS is a STIS with an added articulating mechanism, but otherwise is a similar device. For the purposes of further explanation, the TIS refers to both TIS and STIS unless otherwise specified.TIS is an adjunct medical device for control and guidance of any form of tracheal introducer device through the glottic opening of a patient's airway. This facilitates endotracheal intubation by passage of the endotracheal tube.An airway introducer is placed within and controlled by the TIS, a mechanically specialized sheath, open at both ends, and covering the distal end of the introducer (where control is most relevant). The TIS acts as a relatively stiff channel, or tunnel, for the introducer to be directed through for smooth travel along courses of varied angles. The proceduralist is able to apply curvature in real-time to the TIS-introducer assemblage based on patient anatomy and other clinical factors. Without the TIS as a channel, an introducer alone can be bent at its tip, but it is limited in its ability to move along that axis as it is being proximally controlled, outside of the patient.The mechanistic basis for the sheath's guidance capability is based on composition, including, but not limited to, a hollowed shaft of polytetrafluoroethylene (PTFE), with a specific ID / OD (internal diameter / outer diameter) ratio, such that there is sufficient stiffness for the sheath to act as a guide within which the introducer can travel, whilst maintaining appropriate elasticity for malleable control.The TIS confers additional introducer controllability by minimizing introducer wobble, as introducers can consist of relatively long shaft-like devices, often nearly 60 cm.Introducer guidance by a TIS, but not the simplified version (STIS) includes a distal articulating tip mechanism, angled as needed while in the tracheal space of a patient, and controlled outside of the patient by moving the proximal sheath through a pull sheath mechanism. To recap, the Simplified Tracheal Introducer Sheath (STIS) lacks this articulating mechanism, but otherwise is a similar device.Rotatory control in the case of both the TIS and STIS is achieved by rotating the introducer which sits outside the proximal end of the sheath.A major additional benefit of utilizing a sheath with an introducer is selection of an introducer for placement into a sheath on a case-by-case basis. For example, a smaller, softer tipped introducer could be utilized with a TIS in cases where airway friability or injury is of particular concern; i.e. a mass with high vascularity and bleeding potential. In another example an introducer with a central canal for oxygenation can be utilized with a TIS when the decision is made to oxygenate through the introducer prior to placement of the endotracheal tube.Finally, the TIS, with its integration of an articulating mechanism utilizing a pull sheath is without costly electrical components and thus serves as a cost-effective alternative to fiberoptic intubation with a bronchoscope (often utilized among top academic hospitals), which is often cost prohibitive for many rural and community hospitals to stock. As such, the TIS may improve access of lower socioeconomic classes to important technologies in the management of respiratory failure.

To provide a new coronavirus infectious disease aftereffect therapeutic agent.SOLUTION: A new coronavirus infectious disease aftereffect therapeutic agent screening method includes: an administration step for administering a test substance to a new coronavirus infectious disease aftereffect model animal which is a non-human mammal expressing a SARS-CoV-2 S1 protein; and an evaluation step for assessing changes in symptoms related to the new coronavirus in the model animal before and after administration of the test substance.SELECTED DRAWING: None