383 results about "Lycopersene" patented technology

The invention provides a method for brewing a yellow wine using enzyme preparation and multi-bacteria, characterized in that: the concrete steps are that: soaking glutinous rice in clean water and adding lipase; steaming the glutinous rice and cooling, and adding alpha-amylase and neutral protease into the mixture and incubating and liquefying the mixture; adjusting the pH of mash and adding acid-resistant glucoamylase and incubating, saccharifying and cooling the mixture; adding bran koji, saccharomyces cerivisiae, ester-producing yeast and saccharifying and fermenting the mixture until the alcohol content is 12 degrees; continuously fermenting the mixture until the alcohol content is larger than 15 degrees and squeezing and filtering the mixture; adding stachyose, oligoisomaltose, honey,medlar leach solution and lycopene antioxidant into the filtered solution; processing the above mixture using a microwave alcoholic ripening machine and adding diatomite absorbent into the mixture and quickly freezing the mixture to clarify the mixture and then using a diatomite filter machine to filter the mixture and finally using membrane micro-straining technology to strain and degerm the product. The advantages of the invention are that: the wine taste is rich and strong; the wine body is full and soft and the wine is a health-care wine capable of adjusting the micro-ecological balance of the human digestive system.

The invention relates to the field of medical preparations, in particular to an enteric solid preparation containing lycopene, resveratrol or melatonin and a preparation method of the enteric solid preparation. The enteric solid preparation comprises one or more of lycopene, resveratrol and melatonin as an active ingredient, water-soluble and / or enteric carrier adjuvants or other pharmaceutic adjuvants. The water-soluble carrier adjuvants can be used as water-soluble solid dispersoid carriers; and the enteric carrier adjuvants are enteric polymers and can be used as enteric solid dispersoid carriers or enteric coating film materials. The lycopene, the resveratrol and the melatonin of the enteric solid preparation have favorable dissolubility in the intestinal tract, so that the medicament, namely, the enteric solid preparation, can be rapidly dissolved and released in the intestinal tract, and thus absorption and bioavailability of the lycopene, the resveratrol and the melatonin are increased. The enteric solid preparation containing the lycopene, the resveratrol and the melatonin can be suitable for application and industrial production of oral preparations, such as tablets, particles, pellets, capsules, enteric capsules, enteric coating tablets, enteric coating pellets, enteric coating particles and the like.

A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The genes contained within this cluster encode geranylgeranyl pyrophosphate (GGPP) synthetase (CrtE), isopentenyl pyrophosphate isomerase (Idi), lycopene cyclase (CrtY), phytoene desaturase (CrtI), phytoene synthase (CrtB), and β-carotene hydroxylase (CrtZ). The gene cluster, genes and their products are useful for the conversion of farnesyl pyrophosphate to carotenoids. Vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes by recombinant DNA technology in transformed host organisms are disclosed.

Methods of improving the sun protection factor of human skin and methods of inhibiting the aging of human skin via the oral administration of a composition comprising (a) β-carotene, (b) lutein and (c) lycopene, in a ratio by weight (a):(b):(c) of from 1:0.5:0.5 to 1:1.5:1.5 are described.

A toothpaste formulation is disclosed which comprises hydrogen peroxide; and cetylpyridinium chloride, and wherein the hydrogen peroxide and the cetylpyridinium chloride have been combined in the toothpaste formulation for not more than about seven minutes prior to administration to an individual. A mouth rinse formulation is disclosed which comprises hydrogen peroxide; and cetylpyridinium chloride, and wherein the hydrogen peroxide and the cetylpyridinium chloride have been combined in the mouth rinse formulation for not more than about seven minutes prior to administration to an individual. A whitening gel formulation is disclosed which comprises hydrogen peroxide; and pH adjuster, and wherein the hydrogen peroxide and the pH adjuster have been combined in the whitening gel formulation for not more than about seven minutes prior to administration to an individual. The toothpaste formulation, the mouth rinse formulation, and the whitening gel formulation further comprise lycopene.

The invention discloses a lycopene microcapsule prepared by adopting a double-coating method and a preparation method thereof. An appropriate mixed wall material is adopted, an optimal emulsification condition and a drying technological parameter are researched, a supercritical fluid extraction technology and a superhigh-pressure isomerization treatment technology are combined, a double-coating method is adopted for preparing the lycopene microcapsule, a process for preparing the double-coated lycopene microcapsule adopts porous starch with the usage amount of 0.16% and beta-cyclodextrin with the usage amount of 0.16%, adsorption temperature is 50 DEG C, and adsorption time is 30 minutes; lycopene is closed in a capsule and isolated with the external environment, so that stability to light and oxygen is improved, serviceable range is expanded, the technical bottleneck existing in application of lycopene at present is effectively overcome, ratio of cis-isomer in the prepared lycopene microcapsule is 45-50%, and bioavailability is high; embedding rate can be 97.75%, lycopene carrying capacity is 40.70mg / g, and the lycopene microcapsule has strong practicability and high application value.

Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg / liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg / liter of lutein. The formulas may further comprise docosahexaenoic acid.

An oral composition, suitable as a hypoglycemic agent, includes an isolate from the leaves of Gymnema sylvestre, having a specified molecular weight. The isolate has a molecular weight at least about 3000 Daltons as determined by molecular weight cut-off filtration. Glucose metabolism in a human patient can be regulated by dosage forms that contain the aforesaid isolate from the leaves of Gymnema sylvestre, in combination with a non-metabolizable, water-swellable polysaccharide such as the exudate of Sterculia urens, and a water-soluble polysaccharide such as guar gum. Optionally, the present oral compositions can include a physiologically acceptable calcium source, a physiologically acceptable metal carbonate salt, a physiologically acceptable chromium salt, and / or a physiologically acceptable vanadium compound. In addition, antioxidants such as ascorbic acid, cholecalciferol, d-α-tocopherol, the carotenoids, lycopene, lutein, and the like, can be included as well. The present compositions are useful for amelioration of cholesterolemia, obesity, chronic complications of diabetes and prophylaxis for patients predisposed to the foregoing.

The invention discloses a recombinant bacterium for producing beta-carotene as well as a construction method and application of the recombinant bacterium. The construction method comprises the following steps: respectively constructing superstrong gene expression modules of protein phytoene synthetase / lycopene cyclase coded by beta-carotene synthetic genes optimized by codons, phytoene dehydrogenase, protein geranyl diphosphate synthase coded by MAV (micro aerial vehicle) pathway genes and 3-hydroxy-3-methylglutaryl coenzyme A reductase; assembling the gene expression modules in vitro, so as to obtain four plasmids of the gene expression modules, integrating the plasmids into a host bacteria genome which does not produce beta-carotene and screening orange single colonies, so as to obtain the recombinant bacterium for producing beta-carotene. The recombinant bacterium disclosed by the invention is adopted for producing beta-carotene by fermental cultivation, and the yield of beta-carotene can reach 26.03mg / g DCW. Therefore, the recombinant bacterium has high performance of producing beta-carotene.

The present invention provides a therapeutic composition comprising one or more polyphenols and one or more carotenoids selected from the group consisting of lutein, lycopene and beta-carotene. The invention also provides methods for inhibiting or reducing the production of superoxide ions, NO, TNF-alpha and / or PGE2 in a mammalian subject comprising administering to said subject the aforementioned therapeutic composition.

Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants and microalgae, and (3) create a novel selection system and / or targeting sites for mediating the insertion of genetic material into plant and microalgae plastids. The specific polynucleotides to be used, solely or in any combination thereof, are publicly available from GeneBank and contain open reading frames having sequences that upon expression will produce active proteins with the following enzyme activities: (a) acetoacetyl CoA thiolase (EC 2.3.1.9), (b) 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase (EC 4.1.3.5), (c) HMG-CoA reductase (EC 1.1.1.34), (d) mevalonate kinase (EC 2.7.1.36), (e) phosphomevalonate kinase (EC 2.7.4.2), (f) mevalonate diphosphate decarboxylase (EC 4.1.1.33), (g) isopentenyl diphosphate (IPP) isomerase (EC 5.3.3.2), and (h) phytoene synthase (EC 2.5.1.32).

The invention provides a new quaternary phosphonium salt I for synthesizing the carotenoid and provides a method for preparing such compound and preparing the carotenoid compound especially lycopene by the intermediate. The method skillfully use the necessary reaction substrate activity difference of the the Writing-Homer reaction and Witting reaction and gets the target product by respectively two condensation reactions with ketone and aldehyde. The new method avoids the disadvantages and has a simple operation and an accessible raw material and does not need special reaction equipments and facilitates to achieve industrialisation.

The invention relates to the pharmaceutical preparation field, in particular to a pharmaceutical composition with lycopene. The pharmaceutical composition is characterized in that poloxamer 188 is added so as to greatly improve the water solubility of the lycopene; in particular, after the lycopene and the poloxamer 188 are prepared into solid dispersion or, together with cyclodextrin, are prepared into a cyclodextrin iclusion complex, bioavailability of the lycopene is remarkably improved.

The invention relates to a propolis-lycopene composition. The propolis-lycopene composition comprises: by weight, 2 to 6 parts of propolis, 0.8 to 7.5 parts of a lycopene raw material, 0.07 to 2.2 parts of vitamin E, and 0.075 to 0.5 parts of a selenium nutrient. The invention also relates to a propolis-lycopene composition preparation and especially relates to a propolis-lycopene composition soft capsule and a preparation method thereof. The propolis-lycopene composition is prepared from natural raw materials and has a scientific formula and controllable quality. The propolis-lycopene composition soft capsule has good stability and good disintegration effects. An animal experiment proves that the propolis-lycopene composition soft capsule has an effect of improving immunity and also has good safety.

This invention discloses a method for preparing water-soluble lycopene nanoscale dispersion product. The method comprises: dissolving lycopene or its oleoresin in an organic solvent, mixing the organic phase with an aqueous phase dissolved with an appropriate emusilfier, breaking lycopene into nanoscale by ultrahigh pressure homogenization or ultrasonic breakage, and vacuum-distilling the organic solvent to obtain uniform and stable water-soluble lycopene nanoscale dispersion (50-500 nm). The water-soluble lycopene nanoscale dispersion product can be added into water-based foods at any ratio, which solves the problem of lycopene dissolution in water-based foods. Besides, the nanoscale lycopene particles can easily infiltrate into human cells, which can increase the biological value of lycopene.

The invention provides a method for preparing lycopene by using bacteria fermentation. The employed bacteria is Streptomyces rimosus sub.rimosus. Compared with current normal method, the invention is characterized by short fermentation period, simple system, low cost, high product purity, and suitability for industrial production.

A pharmaceutical composition for use in hair, skin and nail health maintenance, for combined, sequential or simultaneous administration, in any form, via any biological route. In its optimal embodiment the composition consists of a daily intake of 1 tablet that consists of: 5 mcg Vitamin D3, 40 mg Vitamin E (natural source), 60 mg Vitamin C, 8 mg Thiamin (vitamin B1), 4 mg Riboflavin (vitamin B2), 18 mg Niacin (vitamin B3), 10 mg Vitamin B6, 500 mcg Folic Acid, 9 mcg Vitamin B12, 45 mcg Biotin, 40 mg Pantothenic Acid, 12 mg Iron, 75 mg Magnesium, 15 mg Zinc, 200 mcg Iodine, 0.5 mg Manganese, 1 mg Copper, 50 mcg Chromium, 100 mcg Selenium, 10 mg L-Cystine, 2 mg Natural Mixed Carotenoids, 15 mg Grape Seed Extract (95% proanthocyanidins); plus 1 Nutri-dermal softgel capsule that consists of: 300 mg Omega-3 Fish Oil, 6 mg Lutein, 200 mg Starflower Oil, 50 mg Blackcurrant Seed Oil, 4 mg Lycopene, and 5 mg Coenzyme Q10.

The present invention relates to an antioxidant and anti-aging astaxanthin health-care composition and preparation method thereof. The composition comprises the following components in parts by weight: astaxanthin 120-160 parts, lycopene 83-133 parts, and grape seed extracts 67-89 parts. The composition can be processed into hard capsules, soft capsules and oral liquid by adding accessories accepted by the pharmaceutical technology. By using astaxanthin, lycopene, and grape seed extracts as raw materials, aiming at the physical signs and food culture features of Chinese people, and scientifically quantifying and blending the raw materials, the composition maximally exerts the synergistic effect of anti-oxidation, and makes the functional features of these three varieties complement each other, thus leading to comprehensive antioxidant effect and remarkable anti-aging effect.

The invention discloses a meat quality improver for grass carps and a preparation method for the meat quality improver. The meat quality improver is prepared from the following raw materials in part by weight: 5 to 10 parts of astragalus, 5 to 10 parts of Codonopsis pilosula, 10 to 15 parts of eucommia bark, 5 to 10 parts of lycopene, 1 to 5 parts of plumepoppy extract, 8 to 15 parts of phytase, 1 to 3 parts of cysteamine, 20 to 40 parts of lactosucrose and 20 to 40 parts of montmorillonite. The invention has the advantages that: active ingredients for improving the meat quality of freshwater fishes are scientifically matched; and the meat quality improver can remarkably improve the growth of cultured fishes and reduce the fat content of the fishes, and also improves the elasticity of muscle, chewiness, hardness and cohesion so as to ensure that the meat is fresh and delicious.

The present invention provides recombinant DNA comprising a transcription promoter and a downstream sequence to be expressed, in operable linkage therewith, wherein the transcription promoter comprises a region found upstream of the open reading frame of a highly expressed Phaffia gene, preferably a glycolytic pathway gene, more preferably the gene coding for Glyceraldehyde-3-Phosphate Dehydrogenase. Further preferred recombinant DNAs according to the invention contain promoters of ribosomal protein encoding genes, more preferably wherein the transcription promoter comprises a region found upstream of the open reading frame encoding a protein as represented by one of the amino acid sequences depicted in any one of SEQIDNOs: 24 to 50. According to a further aspect of the invention an isolated DNA sequence coding for an enzyme involved in the carotenoid biosynthetic pathway of Phaffia rhodozyma is provided, preferably wherein said enzyme has an activity selected from isopentenyl pyrophosphate isomerase activity, geranylgeranyl pyrophosphate synthase activity, phytoene synthase activity, phytoene desaturase activity and lycopene cyclase activity, still more preferably those coding for an enzyme having an amino acid sequence selected from the one represented by SEQIDNO: 13, SEQIDNO: 15, SEQIDNO: 17, SEQIDNO: 19, SEQIDNO: 21 or SEQIDNO: 23. Further embodiments concern vectors, transformed host organisms, methods for making proteins and / or carotenoids, such as astaxanthin, and methods for isolating highly expressed promoters from Phaffa.

The invention relates to an anti-aging and heart and blood vessel protecting soft capsule and a preparation method thereof. The soft capsule comprises a soft capsule body and contents and is characterized in that the contents comprise 40-60% of seabuckthorm seed oil, 1-3% of lecithin, 1-3% of vitamin E, 4-8% of lycopene, 5-9% of propolis, 20-30% of pumpkin seed oil and 6-10% of collagen protein by weight percentage. The contents are evenly mixed, ground and degassed; gelatin, water and glycerol are weighed by the proportion of 100:100:40, heated for melting materials and degassed to obtain a soft capsule body filtrate; the filtrate and the contents are put in a pelleting machine for pelleting by the weight ratio of 1: (2-3) and the finished product is obtained after shaping, drying, pill washing, picking and packaging. By the synergistic effect of the ingredients of the soft capsule, immunity of a human body can be effectively improved. The soft capsule is scientific in dose and has the function of beautifying, resisting aging, protecting heart and blood vessels, tonifying the kidney and controlling nocturnal emission. The preparation method is reasonable in process and liable to industrialized production and has strong operability.

The invention discloses a lycium chinense miller lycopene beta-cyclase gene, a recombinant vector containing the gene, a host cell and application. Total RNA (Ribonucleic Acid) of fresh lycium chinense miller leaf is extracted, and lycopene beta-cyclase gene LmLycB is cloned by using 3' RACE (Rapid Amplification of cDNA Ends) technology to obtain a complete gene sequence of 1,506bp. An Escherichia coli expression vector pMON-LmLycB is constructed; an escherichia coli heterogenous expression system is applied; the activity of cloned LmLycB gene-coded enzyme is identified; and two beta-lonone rings can be added at the tail end of lycopene by LmLycB to produce beta-carotene. A maize inbred line immature embryo genetic transformation system is optimized; a plant expression vector pCAMBIA2300-LmLycB-Bar containing a target gene is transformed into maize callus to finally obtain a transgenic positive plant; through HPLC (High Performance Liquid Chromatography) detection, the total carotinoid content of transgenic maize leaf is 165.70mug / g FW and is 12.76 percent greater than that of a wild maize; and beta-carotene content is 80.17mug / g FW and is 54.83 percent greater than that of the wild maize.

Two very important factors in human life—which play vital roles in promoting well being—includes returning the body to homeostasis and giving boost to body called lifeforce to get overall health free from diseases, i.e., its optimal balanced functioning ability. When the body is at homeostasis, there is no place for disease. It is only when the body is out of balance (something is deficient, in excess or stagnating) that pain, illness or disease can occur. The application described is based on returning the body to homeostasis (removing the problem and balancing the body) by providing lifeforce and not on dealing with the symptom (e.g., pain, vitamin deficiency). Imbalance results in various diseases and adverse health conditions (starting from aging to diabetes and cancers). This wonderful composition will interact with the body in a way that allows it to boost lifeforce and reach homeostasis no matter which direction it was. In this combination, in the form of liquid, all the 14 ingredients (Lepidium meyenii (Maca), Croton planstigma (Dragon's blood) tree sap, Uncaria tomentosa (Cat's Claw), Morinda citrifolia (Noni fruit) 4:1 PE, Lutein, Lycopene 5%, Flaxseed Oil (Omega-3-Fatty Acids), Vinpocetine, Phosphatidyl Serine 50%, Korean Ginseng 80%, Bacopa monnieri (Bacopin), CDP Choline (Cognizing), Guaranine (Guarana Seed PE 12%), Yerba Mate Ext. 8%) work as mixture for returning the body to homeostasis and give it lifeforce.

Disclosed is a compound tomatine preparation for female and its preparing process, wherein the preparation comprises tomatine, soybean isoflavones, vitamin E, anti-oxidant, capsule stabilizing agent and balancing deflocculating agent. The preparation can be made into the dosage forms of soft capsules, tablets or oral liquids.

The invention discloses edible blend oil and its preparation method. The edible blend oil is prepared from, by weight, 20-30 parts of corn oil, 20-30g of soybean oil, 10-20 parts of rice oil, 10-20 parts of flaxseed oil, 5-10 parts of peanut oil, 1-2 parts of Vitamin E, 0.5-1 part of hydrolysis plant protein, and 0.5-1 part of green tea extractive. The raw material further comprises lycopene, citric acid and medlar extractive. The edible blend oil is high in nutrition value and good in oxidization stability; after eating for a long time, the edible blend oil has good effect to people with hyperlipidemia, high blood pressure and hyperglycemia, patients with cardia-cerebrovascular disease, fatty liver and obesity.

The invention provides a preparation method of a precious cream for deeply whitening and moistening skin, which comprises the following steps: according to parts by weight, taking and adding 0.1-0.2 part of bisabolol into an oil tank, sequentially adding 1.3-1.8 parts of glyceryl stearate citrate, 0.5-0.7 part of beheneth-25, 3-5 parts of cetearyl alcohol, 2.0-2.2 parts of ethylhexyl palmitate, 2-4 parts of mineral oil, 0.8-1.2 parts of di-C12-13 alkyl malate and 2.5-3.2 parts of dimethyl polysiloxane, and heating to 80-88 DEG C; adding 73-78 parts of deionized water into a water tank, heating to 55-65 DEG C, adding 3-6 parts of glycerol and 0.2-0.5 part of allantoin, and heating to 80-88 DEG C; dissolving 0.3-0.7 part of lycopene by utilizing ethylhexyl palmitate for use; preheating and vacuumizing a main tank, sucking the materials in the oil tank and the water tank into the main tank, homogenizing for 7-9 minutes, adding 1.0-1.2 parts of polyacrylamide, and stirring for 2-3 minutes; when the temperature is reduced to 50 DEG C, adding the lycopene, and homogenizing for 2-3 minutes; when the temperature is reduced to 45 DEG C, adding 0.1-0.2 part of benzyl alcohol / chloromethyl isothiazolinone / methyl isothiazolinone, 1.5-2.2 parts of collagen, 0.02-0.04 part of rose essence and 0.5-1.2 parts of polyquaternium-51; and when the temperature is reduced to 40 DEG C and the pH value is 4.0-7.5, discharging.

The present invention relates to a preparation method of lycopene crystal and lycopene concentrate. Said method includes the following steps: pretreating raw material, using weakly alkaline solution to saponify raw material, then using low-molecular alcohol to make treatment, and using organic solvent to make extraction, finally two-temp. crystallizing so as to obtain the dark red lycopene crystal whose purity is greater than 70%, and the purity of lycopene crystal product produced by using said method can be up to above 90%. Said invention also provides its application range.

The invention relates to a lycopene product with rich cis-isomer and a preparation method thereof, belonging to the technical field of the production of functional food ingredients. The preparation method of the invention uses lycopene oleoresin or purified lycopene as raw material and adopts the 'short-time hot reflux-low-temperature standing and crystallization-crystal-removing-solvent-recycling from mother solution' technology to obtain high cis-lycopene product and high-purity all-anti-lycopene product. The preparation method of the invention has the advantage that high cis-lycopene product and high-purity all-anti-lycopene product can be obtained at the same time; the cis-isomer in the high cis-lycopene product is up to 60-95%, the purity of the all-anti-lycopene in crystal is up to over 95%. Production process is simple, the production efficiency is high, and the contrast advantage is obvious.

A nano matre-class lycopene oil is prepared from lycopene with granulity of less than 50 nm in the form of resin and / or crystal and plant oil through high-speed stirring at 30-60 deg.C, pressure-homogenizing under a pressure more than 18 MPa at least for 2 times, and loading in capsules.

The invention discloses health-care food for improving male prostatic diseases. The health-care food comprises components in percentage by weight as follows: 10%-20% of lycopene, 10%-30% of seal oil, 20%-40% of a morindaofficinalis extract, 3%-10% of beeswax and 10%-40% of pumpkin seed oil. The components have various effects and have synergistic interaction, the health-care food has the effects of preventing energy deficiency, hypofunction, prostatic hyperplasia, prostatic hyperplasia, prostatitis and the like, has the advantages of scientific composition, natural components, proper proportion, convenience in taking, reliable effects and avoidance of toxic and side effects, can be taken for a long time and is suitable for prevention and treatment of prostatic diseases for medium-elderly men.