74 results about "Microbial metabolite" patented technology

The invention belongs to the technical field of water treatment, and particularly provides a nitrogen-oxygen co-doped hypha / spruce composite adsorption material and a copper-containing sewage treatment method. According to the invention, the copper-containing sewage is pretreated by using the solid fermentation product, and then the copper-containing sewage is post-treated by using the nitrogen-oxygen co-doped hypha / spruce composite adsorption material prepared under specific conditions; wherein in the pretreatment stage, microbial metabolites in a solid fermentation product preliminarily capture free copper ions (Cu < 2 + >) through complexation, the toxicity of the sewage is reduced, and meanwhile, the copper ions are partially converted into a form which is easier to adsorb. In the post-treatment stage, the nitrogen-oxygen co-doped hypha / spruce composite adsorption material plays a key role, and efficient interception and adsorption of copper ions are achieved. In conclusion, the treatment method for the copper-containing sewage comprises a pretreatment stage and a post-treatment stage, the two stages are in synergistic interaction, and finally the removal rate of the heavy metal copper can be effectively increased.

The invention relates to the technical field of sewage treatment, in particular to a sulfur autotrophic denitrification nitrogen removal device which comprises a reaction tank, and a driving shaft is arranged on the reaction tank; a driving part is arranged at one end of the driving shaft, a cleaning hopper is fixedly connected to the driving shaft through bolts, and a stirring assembly is arranged at the end, away from the driving part, of the driving shaft; a connecting column is fixedly connected to the end, away from the driving part, of the driving shaft, a sliding groove is formed in the connecting column and is in an annular wave shape, and the multiple stirring assemblies are distributed at the connecting column in a circumferential array mode. The device has the advantages that when the device is used, the filter material between the splitter plate and the blocking net can be shifted, so that the situation that the surface of the filter material forms a coating due to microbial metabolites, suspended matter deposition in water and the like during long-term operation or the filter material is compacted and hardened due to non-uniform local water flow is avoided, the contact and mass transfer efficiency of sewage and microorganisms on the filter material is improved, and the service life of the filter material is prolonged. Therefore, the condition that the filter material needs to be replaced after shutdown due to serious hardening of the filter material is avoided, and the treatment efficiency is improved.

The application discloses application of undecyl-prodigiosin in inhibition of a root rot pathogen (Fusarium oxysporum) of Salvia miltiorrhiza, and belongs to the technical field of microbial pesticides. 25 H 33 The compound has a molecular formula of C 50 N3O, is derived from Streptomyces aurantiacus YS-4, has a concentration-dependent inhibitory effect on the Fusarium oxysporum, an EC of 33.1 μg / mL, and an inhibition rate of 83.3% at 400 μg / mL. The application further provides a preparation containing the compound, wherein the concentration of the compound is not less than 20 μg / mL, and the concentration of the target area after application is controlled in a range of 20 μg / mL to 400 μg / mL, so that the root rot of Salvia miltiorrhiza can be effectively prevented and treated. As a natural microbial metabolite, the compound is environment-friendly, has no residue, and is not easy to produce drug resistance, solves the pollution problem of chemical prevention and treatment, and provides a new scheme for green prevention and treatment of the root rot of Salvia miltiorrhiza.

The invention discloses a polyketone compound japondiene A as well as a preparation method and application thereof, and belongs to the technical field of microbial metabolites. According to the present invention, the Aspergillus japonicus TE-739D is found, the polyketone compound japondiene A is successfully separated, extracted and prepared from the metabolic fermentation product of the Aspergillus japonicus TE-739D, and through the SciFindern database retrieval and compared with the currently reported compound, the polyketone compound japondiene A is the new structure compound reported for the first time, and can be used for preparing the new structure compound. Functional studies find that the polyketone compound japondiene A has insecticidal activity on spodoptera frugiperda, and technical support is provided for further development of biopesticides.

The invention relates to the field of biological medicine, and discloses application of PCA and PD-1 antibodies in drug combination for treating liver cancer. It is found that the flora metabolite PCA can improve the tumor immunosuppression microenvironment and enhance the effect of the PD-1 monoclonal antibody in liver cancer treatment, so that the responsiveness of liver cancer to PD-1 monoclonal antibody immunotherapy is improved, the lifetime is prolonged, and prognosis is improved.

The invention provides application of microbial metabolites in tumor immune response and an intestinal microbial metabolite screening method. A screening system is constructed by combining firefly luciferase with PD-1 / SHP-2, various intestinal microbial metabolites are independently co-cultured with the screening system, the screened microbial metabolites are glycodeoxycholic acid and taurocholic acid, and the influence of various metabolites on PD-1 pathway signal transduction is reflected by measuring the activity of luciferase. The invention constructs a reliable, rapid and effective screening method for discovering intestinal microbial metabolites influencing a PD-1 signal channel and evaluating the influence efficacy of the metabolites, and screening out metabolites having effects on intestinal cancer immune response, thereby providing an experimental basis for enhancing intestinal cancer treatment.

The preparation method comprises the following steps: carrying out activation pretreatment on a reverse osmosis membrane base membrane, and introducing a functional anchor point group on the surface of the membrane; a layered assembly mode is adopted, an embedded hydrophilic barrier layer and a nanometer container type sterilization precursor layer are sequentially constructed, and the nanometer container type sterilization precursor layer contains a controllable release structure capable of responding to microbial metabolites or external stimulation; and real-time monitoring and modification regulation are carried out in the layered assembly process. According to the technical scheme, through the design of a controllable release structure, the long-acting antibacterial performance is guaranteed, and the influence of excessive sterilization on the film performance is avoided. Meanwhile, the uniformity and integrity of the functional layer are ensured through real-time monitoring and modification regulation, the service life of the membrane is remarkably prolonged, the operation stability of the membrane is remarkably improved, and the method has important significance in reducing the operation cost of the system and preventing secondary pollution.

The invention belongs to the field of medicines, and particularly discloses application of ImP (Imidazole Propionic Acid) in preparation of medicines for preventing or treating metabolic syndrome related diseases, aiming at the problems that the existing anti-obesity medicines are large in side effect, limited in curative effect and the like, and metabonomics research finds that the peripheral blood ImP level in a high-fat diet induced obesity model is remarkably reduced. A zebra fish model (250 [mu] M) and a human fat cell experiment (10-1000 [mu] M) prove that ImP significantly reduces the lipid accumulation rate by more than 40% (Plt; 0.01) of the substrate. The pharmaceutical composition can be prepared into dosage forms such as oral tablets (for example, each tablet containing 50 mg of ImP), sustained-release injections and the like, and can be theoretically combined with orlistat and other medicines for use. Compared with the traditional therapy, the invention reveals the lipid metabolism regulation function of ImP for the first time, and the ImP has the advantages of strong targeting property (IC50 = 120 mu M), high safety (LD50gt; 2000mg / kg) and the like, and a brand new microbial metabolite intervention strategy is provided for obesity and related metabolic diseases.

The invention discloses a targeted nutrient source mining method based on beef cattle intestinal type-host gene interaction, particularly relates to the field of biological information data processing, and is used for solving the problems that existing nutrient source development lacks molecular mechanism verification and is poor in targeting. The method comprises the following steps: firstly, dividing nutrition-associated intestinal types based on microbiome and transcriptome data, and constructing a co-expression network to screen host co-expression specific genes driven by the specific intestinal types; then, establishing a flora metabolite ligand set and host protein receptor model, executing molecular conformation search and Gibbs free energy calculation, and screening high-activity targeting effect factors based on physical affinity; and finally, traversal matching and quantitative screening are carried out on the natural raw material liquid chromatography-mass spectrometry data by using the targeted effect factors, and a targeted nutrition source recommendation list aiming at the specific intestine type is generated. According to the method, multi-omics correlation analysis and molecular thermodynamics verification are fused, and an accurate development closed loop from micromechanism analysis to macroscopic raw material matching is constructed.

The invention discloses a method for analyzing tryptophan metabolites of intestinal microorganisms, which comprises the following steps: sample pretreatment, on-machine detection and data processing, and can be used for quantitatively analyzing 11 indole derivatives (IAA, IPA, ILA, IArA, IAM, IPYA, IAld, TRM, IET, ICA and IS) in a serum or excrement sample. According to the method, through comprehensive methodology verification, on the basis of keeping high sensitivity and accuracy, one-time analysis can be completed only in 6 minutes on a machine, and the detection efficiency is high; the TRP microbial metabolite indole metabolite detection kit can be used for detecting TRP microbial metabolite indole metabolite, covering 11 types of indole metabolites in serum and excrement samples, covering IAld, IET, IArA and other key indole derivatives related to intestinal flora, realizing relatively comprehensive detection of TRP microbial metabolite indole metabolites, and providing a new tool for revealing a complex mutual relationship between intestinal microorganisms and host health.

The invention belongs to the technical field of advertising, and particularly relates to a multifunctional portable lamp post lamp box which is characterized in that control units are symmetrically arranged on the outer wall of the lamp box, storage units are arranged at the four corners of the end face of one side of the lamp box, and a cleaning unit is arranged on one side of each storage unit; the vertical rail controls the vertical base and synchronously drives the wing plate to reciprocate, in the process, stains deposited on the end face of the advertisement screen are softened through the roller brush, then the advertisement face softened through the roller brush is scraped and cleaned through the relative movement between the double-end shovel and the advertisement face, the cleanliness of the end face of the advertisement screen is fully guaranteed, and the advertisement screen can be conveniently cleaned. The probability that microbial metabolites or other metal particles on the end face of the advertising screen chemically react with acid or alkaline substances in air is reduced, the service life of the advertising screen is prolonged, meanwhile, the phenomenon that dust is deposited on the end face of the advertising screen is fully reduced through periodic scraping of the double-end shovel, and the lighting effect and the propaganda effect of the advertising screen are guaranteed.

The invention relates to the technical field of fertilizers, and discloses a biological protein principle-based fertilizer for preventing and treating citrus liberobacter asiaticum, which is prepared from the following raw materials in parts by weight: 40 to 70 parts of fish protein peptide fermentation products, 5 to 15 parts of EM flora active liquid, 1 to 5 parts of chelated trace element solution and 10 to 20 parts of algal polysaccharide-polyglutamic acid compound. The fish protein peptide is fermented for 180 days or longer through EM bacteria. The EM flora active liquid contains lactic acid bacteria, photosynthetic bacteria, actinomycetes and saccharomycetes. The trace elements are at least two of boron, zinc, iron, manganese and molybdenum and are chelated by polyglutamic acid or sugar alcohol. The small peptide, the bacterial metabolite and the chelate element are in slow release synergy, so that rhizosphere microecology can be rebuilt, defensive enzymes can be induced, and the phenomena of huanglong, yellowing and red nose can be relieved.

The application discloses a kind of film-coated sustained-release solid water-soluble fertilizer and its preparation method and application, including the following weight fraction components: nitrogen source 15~20 parts, phosphorus source 8~12 parts, potassium source 15~25 parts, humic acid 3~8 parts, biochar powder 10~15 parts;Functional microorganism 0.5~1.5 parts, microbial metabolite 1~2 parts, seaweed extract 2~5 parts, chitosan-gelatin composite material 5~8 parts;The functional microorganism is adsorbed on the biochar powder bacillus subtilis, bacillus licheniformis and azotobacter.The film-coated sustained-release solid water-soluble fertilizer provided in the application has the effects of nutrient supply and prevention and control of soil-borne diseases, achieves one fertilizer multiple effects, can improve crop nutrient utilization rate, inhibit soil-borne diseases and promote soil microbial diversification.

The invention relates to a microbial metabolite and an application technology of the microbial metabolite in the field of drug research, in particular to a cytochalasin compound as well as a preparation method and application of the cytochalasin compound. The cytochalasin compound is a compound 1 and a compound 2 as shown in a formula I, the molecular formula of the compound 1 is C29H35NO4, and the structural formula of the compound 1 is 1 in the formula I, and the molecular formula of the compound 2 is C29H37NO3, and the structural formula of the compound 2 is 2 in the formula I. The invention further discloses a preparation method of the cytochalasin compound. Experimental results show that the two compounds show anti-tumor activity on various tumor cell lines, can effectively inhibit cell proliferation, and have the potential of serving as a cell proliferation inhibitor or an anti-tumor preparation. Compared with traditional chemical synthesis, the preparation of the target compound is achieved through the microbial fermentation technology, and the method has the advantages of being simple in operation process, short in production period, low in cost and the like, is suitable for large-scale production and has important application prospects. Formula I

The invention relates to the technical field of special fertilizer effect compositions, and particularly discloses a seedling raising and plant promoting composition for mountain mangoes and a rapid production and field planting method. The composition comprises various components such as microbial metabolite fermentation liquor dry powder, trichoderma fermentation filter residue powder, tea bran residue crushed matter, perlite loaded chitosan oligosaccharide composite particles, a kaolin-sepiolite compound and sodium alginate gel particles, and the core components are matched and coordinated to construct a stable seedling environment structure. The invention further provides a rapid production and field planting method matched with the composition, the whole process of seedling raising, bag transferring, shaping and management before outplanting is covered, and the method is suitable for intensive cultivation and efficient transplanting of mangoes under complex mountain conditions and has good technical adaptability and application prospects.

The invention discloses a potato golden nematode repellent containing plant extract and microbial metabolite, which is prepared from the following components in parts by weight: 20 to 30 parts of plant extract, 10 to 20 parts of traditional Chinese medicine extract, 5 to 10 parts of fluensulfone, 5 to 10 parts of microbial metabolite, 5 to 10 parts of rice chaff, 10 to 20 parts of kieselguhr and 3 to 5 parts of light calcium carbonate. The invention relates to the technical field of combination of botanical pesticides and chemical pesticides. According to the potato golden nematode repellent containing the plant extract and the microbial metabolite, the insect repelling effect of the repellent can be greatly improved through the synergistic effect of the plant extract, the traditional Chinese medicine extract and the microbial metabolite, and the effect that the insect repelling drug is replaced with the pollution-free plant extract and the pollution-free microbial metabolite is well achieved; the aim of greatly reducing environmental pollution is achieved, the insect repelling effect of the potato golden nematode repellent is well enhanced, and therefore the potato golden nematode repellent is very beneficial to repelling of potato golden nematode.

The invention provides penicillium, a composite ore leaching agent based on the penicillium and an ore leaching method of weathering crust elution-deposited rare earth ore. The penicillium XT-1 is preserved in the China Center for Type Culture Collection (CCTCC), the preservation number is CCTCC NO: M20242845, the preservation number is CCTCC NO: M20242845, the preservation number is CCTCC NO: M20242845, and the preservation number is CCTCC NO: M20242845. The composite mineral leaching agent comprises a microbial metabolite of Penicillium sp. XT-1, ammonium sulfate and hydrochloric acid. In the rare earth leaching process, efficient selective extraction of rare earth elements is achieved through the biological-chemical synergistic effect, the problems that a traditional chemical leaching method is large in pollution and large in chemical reagent and energy consumption are solved, and the common problems that the mineral utilization rate is low and leaching is difficult in biological hydrometallurgy are solved.

The invention provides a rare earth complex and application thereof in biological control of cotton verticillium wilt. The rare earth complex comprises the following components in parts by mass: 1-5 parts of catechin polyphenol compounds; 15-25 parts of rare earth chloride salt; 12 to 18 parts of 5-sulfonyl salicylic acid; and 25-60 parts of water. According to the invention, a complex formed by rare earth elements and specific plant extracts or microbial metabolites is utilized, and the purpose of effectively preventing and treating cotton verticillium wilt is achieved by inhibiting growth and reproduction of pathogenic bacteria, destroying cell structures of the pathogenic bacteria or interfering metabolic pathways of the pathogenic bacteria and the like.

The present application relates to the technical fields of microbial fermentation and feed processing, and discloses a multi-strain synergistic oxygen-consuming anaerobic feed fermentation method, which comprises the following steps: inoculating a compound fermentation inoculum containing an oxygen-consuming functional flora and an anaerobic functional flora into a feed fermentation substrate with adjusted moisture content and initial pH value at one time, and the ratio of viable bacterial count is 1:1.5-1:2.5; performing first-stage oxygen-consuming fermentation on the fermentation system, maintaining oxygen supply operation until the internal center temperature naturally rises to 40-45 DEG C; then stopping the oxygen supply operation and not performing secondary inoculation, directly applying mechanical pressure to the fermentation system to perform forced compaction and exhaust and performing physical sealing, so that the system performs second-stage anaerobic fermentation until the pH value drops to a preset acidic range, and fermented feed is prepared. The process conversion triggered by one-time inoculation and natural temperature rise avoids the introduction of external miscellaneous bacteria by segmented inoculation, and a low-oxygen high-acidity environment is constructed through microbial metabolites and physical sealing.

The invention relates to the technical field of animal health, in particular to a microbial metabolite for reducing metritis and a screening method and application thereof. According to the invention, metritis of laying fowls, which is obtained by researching microorganisms related to metritis of broiler breeding chickens, is caused by complex interaction of age-related inflammatory response, microbial flora imbalance and tryptophan metabolism disorder. On the basis of 16sRNA gene sequencing, high performance liquid chromatography-mass spectrometry and other methods, a specific metabolite indole-3-acetaldehyde is screened out, and the model animal verifies that the indole-3-acetaldehyde is applied to treatment or prevention of body metritis.

The invention belongs to the technical field of biological medicine and tumor immunotherapy, and discloses application of 3-oxo-valproic acid coenzyme A in preparation of a medicine for inhibiting lung adenocarcinoma. As a specific agonist of GIMAP1, the 3-oxo-valproic acid coenzyme A is used for activating the GIMAP1, enhancing inhibition of lung cancer cell progress and enhancing activation of a tumor immune microenvironment, so that the lung adenocarcinoma is inhibited, and the lung adenocarcinoma is inhibited. The invention has the following beneficial effects: 1, strong targeting property: 3-oxo-valproate coenzyme A is specifically combined with GIMAP1, so that a mediated immunomodulatory pathway is accurately activated, and wide influence on normal cells is avoided; 2, immune microenvironment remodeling: the anti-tumor immune cell infiltration is remarkably improved, the lung adenocarcinoma immunosuppression microenvironment is reversed, and the immunotherapy sensitivity is improved; 3, tumor progression is inhibited, lung cancer cell proliferation is effectively inhibited, and the tumor invasion ability is reduced; 4, the source is natural: as an intestinal microbial metabolite derivative, the safety is high, and the side effect is lower than that of a chemically synthesized medicine.

The invention discloses lachnum brevipilosum and application of the lachnum brevipilosum, and belongs to the technical field of fungal biology. The strain is separated from Vaccinium dunalianum twigs, can be used as a microbial source of a natural wood flavoring material, and particularly, it is found that the strain can produce (-)-isohorn ene in microbial metabolites for the first time, so that the blank of synthesis research of microbial wood flavoring components is filled up; the application method comprises the steps of strain activation, solid fermentation culture, dynamic collection of headspace volatile matters and the like, and a fermentation product is composite fragrance containing alcohols, olefins and other components and has rich-layered wood-soil fragrance-spicy composite fragrance; the natural wood perfume is produced in a microbial fermentation mode, the problems that plant raw materials are long in growth cycle and unstable in supply can be solved, and the method has the advantages of being controllable in process, not limited by seasons and regions and high in sustainability.

The utility model discloses a multi-layer animal pesticide residue purification powder which comprises a biological activity core layer, a heavy metal chelating layer is arranged on the outer side of the biological activity core layer, an organic toxin and pesticide residue toxin decomposition layer is arranged on the outer side of the heavy metal chelating layer, a slow release layer is arranged on the outer side of the organic toxin and pesticide residue toxin decomposition layer, and the slow release layer is arranged on the outer side of the biological activity core layer. An intestinal tract adsorption layer is arranged on the outer side of the slow-release layer, a sugar-coating layer is arranged on the outer side of the intestinal tract adsorption layer, the bioactive core layer, the heavy metal chelating layer, the organic toxin and pesticide residue toxin decomposition layer, the slow-release layer, the intestinal tract adsorption layer and the sugar-coating layer form a multi-layer structure from inside to outside, and the multiple layers are matched. Microbial metabolites, heavy metals, organic toxins and pesticide residue toxins are sequentially treated from inside to outside, and mutual interference of components is avoided; the probiotics on the core layer continuously generate metabolites after colonization in intestinal tracts, so that the animals can discharge heavy metals and toxins.

The invention relates to the technical field of animal growth regulation, in particular to application of all-trans retinoic acid in regulation of oxidation resistance and digestion and metabolism capacity of Ningxiang pigs. According to the application, all-trans-retinoic acid is added into the Ningxiang pig feed, and the research on the antioxidant capacity of intestinal microorganisms and serum of the Ningxiang pig feed shows that all-trans-retinoic acid can improve the antioxidant capacity of the Ningxiang pig by enhancing the total antioxidant capacity of the Ningxiang pig, changing the diversity of intestinal flora of the Ningxiang pig and changing microbial metabolites and metabolic pathways of the intestinal flora; the biosynthesis and metabolism of amino acids are promoted, so that the oxidation resistance and digestion and metabolism capabilities of the Ningxiang pigs are enhanced.

The invention discloses a polyketone-like compound Japonidiene E as well as a preparation method and application thereof, and belongs to the technical field of microbial metabolites. According to the present invention, the Aspergillus japonicus TE-739D is found, the polyketone-like compound Japonidiene E is successfully separated, extracted and prepared from the metabolic fermentation product of the Aspergillus japonicus TE-739D, and through the SciFindern database retrieval and compared with the currently reported compound, the polyketone-like compound Japonidiene E is the new structure compound reported for the first time, and has the advantages of simple preparation process, low cost, low cost and the like. Functional studies find that the polyketone-like compound Japonidiene E has a strong inhibition effect on germination of amaranthus retroflexus and eleusine indica seeds, the effect of the polyketone-like compound Japonidiene E is superior to that of a positive drug glyphosate, and a technical support is provided for further development of biopesticides.

The application discloses a construction method of a microbial-metabolite-host regulation network of summer South China calf based on Lactobacillus reuteri, and belongs to the technical field of microorganisms. The construction method comprises the following steps: collecting rumen, fecal sample and whole blood sample of the summer South China calf; obtaining microbial layer data through 16S rRNA sequencing, obtaining metabolite layer data through non-target metabolomics, and obtaining host gene / pathway layer data through whole blood transcriptomics; performing correlation analysis on multi-omics data to obtain a microbial-metabolite-host regulation correlation network. The regulation network significantly improves the growth performance of the summer South China calf, relieves diarrhea and enhances the digestive absorption function by improving the abundance of gastrointestinal beneficial bacteria, promoting the secretion of short-chain fatty acids and activating the host immune antioxidant pathway. The application realizes the precise mechanized application of probiotics by clarifying the regulation correlation among the three, and provides a mechanism-application integrated scheme for healthy breeding of calves.

The invention discloses a medicine relocation system and method based on a quantum graph Fourier convolution network. The method comprises the following steps: integrating proteins, genes, microorganisms, metabolites, drugs, diseases and multi-source associated information of the proteins, the genes, the microorganisms, the metabolites, the drugs, the diseases to construct a heterogeneous biological information network and a local subgraph network; the method comprises the following steps: innovatively designing a quantum graph Fourier convolution network, extracting spectrum characteristics and topological information of protein, gene, microorganism, metabolite, medicine and disease nodes from a heterogeneous biological information network, updating medicine and disease node information, and obtaining discriminative characteristic representation; a multi-layer sensor is used for learning and depicting medicine-disease joint feature representation, and then the unknown curative effect of the medicine is predicted. According to the method, data mining and knowledge discovery are carried out based on the multi-source heterogeneous biological information network, the quantum Fourier graph convolutional network is innovatively used for modeling the multi-source heterogeneous biological network, high-order semantic dependence and a global structure mode between drugs and diseases can be effectively extracted, the performance of a drug relocation prediction system is improved, and the system is suitable for large-scale popularization and application. And the method has good expandability and practical application prospects.

The present invention relates to microbial metabolites and their application technology in the research field of agricultural fungal control drugs, specifically an application of a chloro-p-benzoquinone compound. The application of a chloro-p-benzoquinone compound as a new control drug for agricultural fungi. The chloro-p-benzoquinone compound is 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione, as shown below #imgabs0# The chloro-p-benzoquinone compound involved in the present invention (as shown in structural formula I) can be used as a new drug ingredient or lead compound for resisting agricultural fungi. The chloro-p-benzoquinone compound involved in the present invention has significant anti-agricultural fungal activity, and its mechanism of action can be further explored in order to develop it into a new pesticide or its lead compound.

The invention belongs to the technical field of animal nutrition and feed science, and discloses an animal feed additive containing a plant extract and organic acid and application of the animal feed additive. The additive is a composite microecological preparation particle and comprises a functional carrier which is composed of plant polysaccharide with prebiotic properties and has a three-dimensional porous network structure, the plant extract microcapsules are embedded in the functional carrier and are of a core-double shell structure, and each microcapsule is provided with a pH-responsive inner shell and a microbial metabolite-responsive outer shell. The functional carrier contains one or more probiotic-oligosaccharide interpolymers which are loaded in the functional carrier and are used as intestinal in-situ organic acid generation units. According to the invention, the time and space synergistic effect of the plant extract and the in-situ generated organic acid in the animal intestinal tract is realized, and the problems of isolated action, passive release and unstable effect of the additive components in the prior art are solved.