99 results about "Microbial metabolite" patented technology

The invention relates to the field of fertilizers, in particular to a stable fertilizer for preventing and treating peanut root rot and a preparation method thereof, and the fertilizer comprises a fertilizer inner core layer, a nano microbial metabolite layer and a microbial protective layer from inside to outside. According to the stable fertilizer for preventing and treating peanut rhizome rot, the capsule embedding inhibitor made of humic acid and the trichoderma aureoviride metabolite are adopted to construct a dual nitrification inhibition system, and the capsule embedding inhibitor and the trichoderma aureoviride metabolite have a synergistic effect, so that the nitrification effect is reduced, the nitrogen fertilizer utilization rate is increased, and non-point source pollution is reduced.

The invention relates to a method for identifying a disease microorganism-metabolite combined marker based on a host-flora co-metabolism model. The method comprises the following steps: processing microbiome data; setting diet constraint conditions; determining classification composition of intestinal microorganisms of each individual, mapping abundance of each microorganism to a human microorganism genome scale metabolism model, and constructing an individualized flora metabolism network model; carrying out metabolic flow simulation on the constructed flora metabolism network model; integrating the constructed flora metabolism network model with the host metabolism network model, and predicting the metabolic flow and metabolite change of the whole system; and establishing a disease classifier based on a random forest machine learning algorithm to identify the microorganism-metabolite combined marker. According to the method, the complex metabolic process between the human body and the intestinal flora is restored in a metabolic network modeling and metabolic flow simulation mode, the method has the non-invasive characteristic, the time and economic cost is remarkably reduced, and meanwhile, the method has a great advantage in accuracy.

The invention relates to the technical field of food safety detection, and discloses a konjac food safety detection and analysis system based on the Internet of Things, which comprises an edge intelligent sensing layer, a pollution field dynamic reconstruction engine and a lightweight block chain data layer, and is characterized in that microbial metabolite and surface component information is collected in real time through a multi-modal sensor array; a dynamic threshold self-adaptive algorithm is combined, the detection sensitivity is intelligently adjusted according to different processing stages, the recognition accuracy of dynamic pollution is improved, a pollution field dynamic reconstruction engine adopts a space-time correlation modeling and transfer learning algorithm, a continuous pollution concentration field is formed, the diffusion trend is predicted, and the detection accuracy is improved. Meanwhile, the self-healing logic chain can reconstruct a pollution field when local nodes are abnormal, it is ensured that monitoring is not interrupted, a block chain double-chain structure is matched with an intelligent contract mechanism, and dynamic balance of enterprise self-inspection data privacy protection and supervision traceability verification is achieved.

The invention discloses a coated slow-release solid water-soluble fertilizer as well as a preparation method and application thereof. The coated slow-release solid water-soluble fertilizer comprises the following components in parts by weight: 15-20 parts of a nitrogen source, 8-12 parts of a phosphorus source, 15-25 parts of a potassium source, 3-8 parts of humic acid and 10-15 parts of charcoal powder, the composite material comprises the following components in parts by weight: 0.5-1.5 parts of functional microorganisms, 1-2 parts of microbial metabolite, 2-5 parts of seaweed extract and 5-8 parts of chitosan-gelatin composite material. The functional microorganisms are bacillus subtilis, bacillus licheniformis and azospirillum which are adsorbed on the charcoal powder. The coated slow-release solid water-soluble fertilizer provided by the invention has the effects of supplying nutrients and preventing and treating soil-borne diseases, achieves multiple effects by one fertilizer, and can improve the crop nutrient utilization rate, inhibit the soil-borne diseases and promote the diversity of soil microorganisms.

The invention belongs to the technical field of water treatment, and particularly provides a nitrogen-oxygen co-doped hypha / spruce composite adsorption material and a copper-containing sewage treatment method. According to the invention, the copper-containing sewage is pretreated by using the solid fermentation product, and then the copper-containing sewage is post-treated by using the nitrogen-oxygen co-doped hypha / spruce composite adsorption material prepared under specific conditions; wherein in the pretreatment stage, microbial metabolites in a solid fermentation product preliminarily capture free copper ions (Cu < 2 + >) through complexation, the toxicity of the sewage is reduced, and meanwhile, the copper ions are partially converted into a form which is easier to adsorb. In the post-treatment stage, the nitrogen-oxygen co-doped hypha / spruce composite adsorption material plays a key role, and efficient interception and adsorption of copper ions are achieved. In conclusion, the treatment method for the copper-containing sewage comprises a pretreatment stage and a post-treatment stage, the two stages are in synergistic interaction, and finally the removal rate of the heavy metal copper can be effectively increased.

The invention relates to the technical field of underground water, in particular to an underground water pollution source analysis and risk assessment method and system.The method comprises the following steps that monitoring points are arranged in a potential underground water affected area, water samples are collected, and organic pollutants, heavy metal content and microbial metabolites in the water samples are analyzed; collecting the characteristic spectrum data of the pollutants, and carrying out normalization processing to obtain a pollutant spectrum characteristic set; according to the method, the organic pollutants, the heavy metals and the microbial metabolites in the water sample are analyzed by using a liquid chromatography-mass spectrometry technology, accurate detection of the trace pollutants is realized, the data standardization level is improved through normalization processing of the pollutant spectral feature set, cross-regional data comparison and analysis are facilitated, and the detection accuracy is improved. The pollution source can be quickly identified through automatic data comparison, errors are reduced, the response speed is increased, and detailed analysis of spatial distribution data provides a comprehensive pollution diffusion picture, so that risk assessment is more comprehensive.

The invention relates to the technical field of sewage treatment, in particular to a sulfur autotrophic denitrification nitrogen removal device which comprises a reaction tank, and a driving shaft is arranged on the reaction tank; a driving part is arranged at one end of the driving shaft, a cleaning hopper is fixedly connected to the driving shaft through bolts, and a stirring assembly is arranged at the end, away from the driving part, of the driving shaft; a connecting column is fixedly connected to the end, away from the driving part, of the driving shaft, a sliding groove is formed in the connecting column and is in an annular wave shape, and the multiple stirring assemblies are distributed at the connecting column in a circumferential array mode. The device has the advantages that when the device is used, the filter material between the splitter plate and the blocking net can be shifted, so that the situation that the surface of the filter material forms a coating due to microbial metabolites, suspended matter deposition in water and the like during long-term operation or the filter material is compacted and hardened due to non-uniform local water flow is avoided, the contact and mass transfer efficiency of sewage and microorganisms on the filter material is improved, and the service life of the filter material is prolonged. Therefore, the condition that the filter material needs to be replaced after shutdown due to serious hardening of the filter material is avoided, and the treatment efficiency is improved.

The application discloses application of undecyl-prodigiosin in inhibition of a root rot pathogen (Fusarium oxysporum) of Salvia miltiorrhiza, and belongs to the technical field of microbial pesticides. 25 H 33 The compound has a molecular formula of C 50 N3O, is derived from Streptomyces aurantiacus YS-4, has a concentration-dependent inhibitory effect on the Fusarium oxysporum, an EC of 33.1 μg / mL, and an inhibition rate of 83.3% at 400 μg / mL. The application further provides a preparation containing the compound, wherein the concentration of the compound is not less than 20 μg / mL, and the concentration of the target area after application is controlled in a range of 20 μg / mL to 400 μg / mL, so that the root rot of Salvia miltiorrhiza can be effectively prevented and treated. As a natural microbial metabolite, the compound is environment-friendly, has no residue, and is not easy to produce drug resistance, solves the pollution problem of chemical prevention and treatment, and provides a new scheme for green prevention and treatment of the root rot of Salvia miltiorrhiza.

The present invention relates to the technical field of food safety detection, and discloses a konjac food safety detection and analysis system based on the Internet of Things, including: an edge intelligent perception layer, a pollution field dynamic reconstruction engine, and a lightweight blockchain data layer. The system collects microbial metabolite and surface component information in real time through a multi-modal sensor array, combines a dynamic threshold adaptive algorithm, and intelligently adjusts the detection sensitivity according to different processing stages, improving the recognition accuracy of dynamic pollution. The pollution field dynamic reconstruction engine uses spatio-temporal correlation modeling and transfer learning algorithms to form a continuous pollution concentration field and predict the diffusion trend. At the same time, the self-healing logic chain can reconstruct the pollution field when local nodes are abnormal to ensure uninterrupted monitoring. The blockchain double-chain structure cooperates with the intelligent contract mechanism to achieve a dynamic balance between the privacy protection of enterprise self-inspection data and the verification of regulatory traceability.

The invention discloses a polyketone compound japondiene A as well as a preparation method and application thereof, and belongs to the technical field of microbial metabolites. According to the present invention, the Aspergillus japonicus TE-739D is found, the polyketone compound japondiene A is successfully separated, extracted and prepared from the metabolic fermentation product of the Aspergillus japonicus TE-739D, and through the SciFindern database retrieval and compared with the currently reported compound, the polyketone compound japondiene A is the new structure compound reported for the first time, and can be used for preparing the new structure compound. Functional studies find that the polyketone compound japondiene A has insecticidal activity on spodoptera frugiperda, and technical support is provided for further development of biopesticides.

The invention relates to the field of biological medicine, and discloses application of PCA and PD-1 antibodies in drug combination for treating liver cancer. It is found that the flora metabolite PCA can improve the tumor immunosuppression microenvironment and enhance the effect of the PD-1 monoclonal antibody in liver cancer treatment, so that the responsiveness of liver cancer to PD-1 monoclonal antibody immunotherapy is improved, the lifetime is prolonged, and prognosis is improved.

The invention provides application of microbial metabolites in tumor immune response and an intestinal microbial metabolite screening method. A screening system is constructed by combining firefly luciferase with PD-1 / SHP-2, various intestinal microbial metabolites are independently co-cultured with the screening system, the screened microbial metabolites are glycodeoxycholic acid and taurocholic acid, and the influence of various metabolites on PD-1 pathway signal transduction is reflected by measuring the activity of luciferase. The invention constructs a reliable, rapid and effective screening method for discovering intestinal microbial metabolites influencing a PD-1 signal channel and evaluating the influence efficacy of the metabolites, and screening out metabolites having effects on intestinal cancer immune response, thereby providing an experimental basis for enhancing intestinal cancer treatment.

The preparation method comprises the following steps: carrying out activation pretreatment on a reverse osmosis membrane base membrane, and introducing a functional anchor point group on the surface of the membrane; a layered assembly mode is adopted, an embedded hydrophilic barrier layer and a nanometer container type sterilization precursor layer are sequentially constructed, and the nanometer container type sterilization precursor layer contains a controllable release structure capable of responding to microbial metabolites or external stimulation; and real-time monitoring and modification regulation are carried out in the layered assembly process. According to the technical scheme, through the design of a controllable release structure, the long-acting antibacterial performance is guaranteed, and the influence of excessive sterilization on the film performance is avoided. Meanwhile, the uniformity and integrity of the functional layer are ensured through real-time monitoring and modification regulation, the service life of the membrane is remarkably prolonged, the operation stability of the membrane is remarkably improved, and the method has important significance in reducing the operation cost of the system and preventing secondary pollution.

The invention belongs to the field of medicines, and particularly discloses application of ImP (Imidazole Propionic Acid) in preparation of medicines for preventing or treating metabolic syndrome related diseases, aiming at the problems that the existing anti-obesity medicines are large in side effect, limited in curative effect and the like, and metabonomics research finds that the peripheral blood ImP level in a high-fat diet induced obesity model is remarkably reduced. A zebra fish model (250 [mu] M) and a human fat cell experiment (10-1000 [mu] M) prove that ImP significantly reduces the lipid accumulation rate by more than 40% (Plt; 0.01) of the substrate. The pharmaceutical composition can be prepared into dosage forms such as oral tablets (for example, each tablet containing 50 mg of ImP), sustained-release injections and the like, and can be theoretically combined with orlistat and other medicines for use. Compared with the traditional therapy, the invention reveals the lipid metabolism regulation function of ImP for the first time, and the ImP has the advantages of strong targeting property (IC50 = 120 mu M), high safety (LD50gt; 2000mg / kg) and the like, and a brand new microbial metabolite intervention strategy is provided for obesity and related metabolic diseases.

The invention discloses a targeted nutrient source mining method based on beef cattle intestinal type-host gene interaction, particularly relates to the field of biological information data processing, and is used for solving the problems that existing nutrient source development lacks molecular mechanism verification and is poor in targeting. The method comprises the following steps: firstly, dividing nutrition-associated intestinal types based on microbiome and transcriptome data, and constructing a co-expression network to screen host co-expression specific genes driven by the specific intestinal types; then, establishing a flora metabolite ligand set and host protein receptor model, executing molecular conformation search and Gibbs free energy calculation, and screening high-activity targeting effect factors based on physical affinity; and finally, traversal matching and quantitative screening are carried out on the natural raw material liquid chromatography-mass spectrometry data by using the targeted effect factors, and a targeted nutrition source recommendation list aiming at the specific intestine type is generated. According to the method, multi-omics correlation analysis and molecular thermodynamics verification are fused, and an accurate development closed loop from micromechanism analysis to macroscopic raw material matching is constructed.

The invention discloses a method for analyzing tryptophan metabolites of intestinal microorganisms, which comprises the following steps: sample pretreatment, on-machine detection and data processing, and can be used for quantitatively analyzing 11 indole derivatives (IAA, IPA, ILA, IArA, IAM, IPYA, IAld, TRM, IET, ICA and IS) in a serum or excrement sample. According to the method, through comprehensive methodology verification, on the basis of keeping high sensitivity and accuracy, one-time analysis can be completed only in 6 minutes on a machine, and the detection efficiency is high; the TRP microbial metabolite indole metabolite detection kit can be used for detecting TRP microbial metabolite indole metabolite, covering 11 types of indole metabolites in serum and excrement samples, covering IAld, IET, IArA and other key indole derivatives related to intestinal flora, realizing relatively comprehensive detection of TRP microbial metabolite indole metabolites, and providing a new tool for revealing a complex mutual relationship between intestinal microorganisms and host health.

The invention belongs to the technical field of advertising, and particularly relates to a multifunctional portable lamp post lamp box which is characterized in that control units are symmetrically arranged on the outer wall of the lamp box, storage units are arranged at the four corners of the end face of one side of the lamp box, and a cleaning unit is arranged on one side of each storage unit; the vertical rail controls the vertical base and synchronously drives the wing plate to reciprocate, in the process, stains deposited on the end face of the advertisement screen are softened through the roller brush, then the advertisement face softened through the roller brush is scraped and cleaned through the relative movement between the double-end shovel and the advertisement face, the cleanliness of the end face of the advertisement screen is fully guaranteed, and the advertisement screen can be conveniently cleaned. The probability that microbial metabolites or other metal particles on the end face of the advertising screen chemically react with acid or alkaline substances in air is reduced, the service life of the advertising screen is prolonged, meanwhile, the phenomenon that dust is deposited on the end face of the advertising screen is fully reduced through periodic scraping of the double-end shovel, and the lighting effect and the propaganda effect of the advertising screen are guaranteed.

The invention relates to the technical field of fertilizers, and discloses a biological protein principle-based fertilizer for preventing and treating citrus liberobacter asiaticum, which is prepared from the following raw materials in parts by weight: 40 to 70 parts of fish protein peptide fermentation products, 5 to 15 parts of EM flora active liquid, 1 to 5 parts of chelated trace element solution and 10 to 20 parts of algal polysaccharide-polyglutamic acid compound. The fish protein peptide is fermented for 180 days or longer through EM bacteria. The EM flora active liquid contains lactic acid bacteria, photosynthetic bacteria, actinomycetes and saccharomycetes. The trace elements are at least two of boron, zinc, iron, manganese and molybdenum and are chelated by polyglutamic acid or sugar alcohol. The small peptide, the bacterial metabolite and the chelate element are in slow release synergy, so that rhizosphere microecology can be rebuilt, defensive enzymes can be induced, and the phenomena of huanglong, yellowing and red nose can be relieved.

The application discloses a kind of film-coated sustained-release solid water-soluble fertilizer and its preparation method and application, including the following weight fraction components: nitrogen source 15~20 parts, phosphorus source 8~12 parts, potassium source 15~25 parts, humic acid 3~8 parts, biochar powder 10~15 parts;Functional microorganism 0.5~1.5 parts, microbial metabolite 1~2 parts, seaweed extract 2~5 parts, chitosan-gelatin composite material 5~8 parts;The functional microorganism is adsorbed on the biochar powder bacillus subtilis, bacillus licheniformis and azotobacter.The film-coated sustained-release solid water-soluble fertilizer provided in the application has the effects of nutrient supply and prevention and control of soil-borne diseases, achieves one fertilizer multiple effects, can improve crop nutrient utilization rate, inhibit soil-borne diseases and promote soil microbial diversification.

The invention discloses a dead fish salvaging device for aquaculture, which relates to the technical field of dead fish salvaging. The device comprises a hull and a first fixed frame, wherein one end of the conveying frame is fixedly connected with a cleaning mechanism, and a cleaning net is arranged below the salvaging frame through the cleaning mechanism, so that the dead fish can be salvaged in a manner of moving the cleaning net from the bottom of the water to the surface of the water, and the cleaning net can salvage microorganisms, microbial metabolites and the like in the inner side of the water body around the dead fish; and the microorganisms and microbial metabolites are temporarily stored on the inner side of the cleaning net, and after the salvaging frame salvages the dead fish, the side plates and the stirring rod are rapidly rotated back and forth in the water body around the dead fish, and the water body around the dead fish can be rapidly mixed with the water body in other areas through the rapid stirring of the side plates and the stirring rod, so as to increase the oxygen content of the water body around the dead fish, and the oxygenation can make the environmental conditions unfavorable for the growth of some anaerobic harmful microorganisms (such as Desulfurization Vibrio that produces harmful substances such as hydrogen sulfide).

The invention relates to a microbial metabolite and an application technology of the microbial metabolite in the field of drug research, in particular to a cytochalasin compound as well as a preparation method and application of the cytochalasin compound. The cytochalasin compound is a compound 1 and a compound 2 as shown in a formula I, the molecular formula of the compound 1 is C29H35NO4, and the structural formula of the compound 1 is 1 in the formula I, and the molecular formula of the compound 2 is C29H37NO3, and the structural formula of the compound 2 is 2 in the formula I. The invention further discloses a preparation method of the cytochalasin compound. Experimental results show that the two compounds show anti-tumor activity on various tumor cell lines, can effectively inhibit cell proliferation, and have the potential of serving as a cell proliferation inhibitor or an anti-tumor preparation. Compared with traditional chemical synthesis, the preparation of the target compound is achieved through the microbial fermentation technology, and the method has the advantages of being simple in operation process, short in production period, low in cost and the like, is suitable for large-scale production and has important application prospects. Formula I

The invention discloses intelligent optimization of soil microbial community and plant synergistic remediation in a phytoremediation experimental facility, and a system monitors soil pollutants, microbial metabolites and plant root exudates in real time, utilizes a microbial sensor and a nano-robot modified by synthetic biology, and an optogenetics technology to realize intelligent optimization of soil microbial community and plant synergistic remediation. Plant-microorganism interaction, a quantum annealing algorithm and a federated learning framework are optimized to generate an optimal repair strategy, the bionic mechanical arm and the laser-nanotechnology execute precise operation, the microbial fuel cell and the piezoelectric energy recovery unit realize self-energy supply of the system, and the system has the characteristics of high efficiency, intelligence and environmental friendliness and is suitable for large-scale popularization and application. The method is suitable for repairing complex soil pollution.

The invention relates to the technical field of special fertilizer effect compositions, and particularly discloses a seedling raising and plant promoting composition for mountain mangoes and a rapid production and field planting method. The composition comprises various components such as microbial metabolite fermentation liquor dry powder, trichoderma fermentation filter residue powder, tea bran residue crushed matter, perlite loaded chitosan oligosaccharide composite particles, a kaolin-sepiolite compound and sodium alginate gel particles, and the core components are matched and coordinated to construct a stable seedling environment structure. The invention further provides a rapid production and field planting method matched with the composition, the whole process of seedling raising, bag transferring, shaping and management before outplanting is covered, and the method is suitable for intensive cultivation and efficient transplanting of mangoes under complex mountain conditions and has good technical adaptability and application prospects.

The invention discloses a potato golden nematode repellent containing plant extract and microbial metabolite, which is prepared from the following components in parts by weight: 20 to 30 parts of plant extract, 10 to 20 parts of traditional Chinese medicine extract, 5 to 10 parts of fluensulfone, 5 to 10 parts of microbial metabolite, 5 to 10 parts of rice chaff, 10 to 20 parts of kieselguhr and 3 to 5 parts of light calcium carbonate. The invention relates to the technical field of combination of botanical pesticides and chemical pesticides. According to the potato golden nematode repellent containing the plant extract and the microbial metabolite, the insect repelling effect of the repellent can be greatly improved through the synergistic effect of the plant extract, the traditional Chinese medicine extract and the microbial metabolite, and the effect that the insect repelling drug is replaced with the pollution-free plant extract and the pollution-free microbial metabolite is well achieved; the aim of greatly reducing environmental pollution is achieved, the insect repelling effect of the potato golden nematode repellent is well enhanced, and therefore the potato golden nematode repellent is very beneficial to repelling of potato golden nematode.

The invention provides penicillium, a composite ore leaching agent based on the penicillium and an ore leaching method of weathering crust elution-deposited rare earth ore. The penicillium XT-1 is preserved in the China Center for Type Culture Collection (CCTCC), the preservation number is CCTCC NO: M20242845, the preservation number is CCTCC NO: M20242845, the preservation number is CCTCC NO: M20242845, and the preservation number is CCTCC NO: M20242845. The composite mineral leaching agent comprises a microbial metabolite of Penicillium sp. XT-1, ammonium sulfate and hydrochloric acid. In the rare earth leaching process, efficient selective extraction of rare earth elements is achieved through the biological-chemical synergistic effect, the problems that a traditional chemical leaching method is large in pollution and large in chemical reagent and energy consumption are solved, and the common problems that the mineral utilization rate is low and leaching is difficult in biological hydrometallurgy are solved.

The invention provides a rare earth complex and application thereof in biological control of cotton verticillium wilt. The rare earth complex comprises the following components in parts by mass: 1-5 parts of catechin polyphenol compounds; 15-25 parts of rare earth chloride salt; 12 to 18 parts of 5-sulfonyl salicylic acid; and 25-60 parts of water. According to the invention, a complex formed by rare earth elements and specific plant extracts or microbial metabolites is utilized, and the purpose of effectively preventing and treating cotton verticillium wilt is achieved by inhibiting growth and reproduction of pathogenic bacteria, destroying cell structures of the pathogenic bacteria or interfering metabolic pathways of the pathogenic bacteria and the like.

The present application relates to the technical fields of microbial fermentation and feed processing, and discloses a multi-strain synergistic oxygen-consuming anaerobic feed fermentation method, which comprises the following steps: inoculating a compound fermentation inoculum containing an oxygen-consuming functional flora and an anaerobic functional flora into a feed fermentation substrate with adjusted moisture content and initial pH value at one time, and the ratio of viable bacterial count is 1:1.5-1:2.5; performing first-stage oxygen-consuming fermentation on the fermentation system, maintaining oxygen supply operation until the internal center temperature naturally rises to 40-45 DEG C; then stopping the oxygen supply operation and not performing secondary inoculation, directly applying mechanical pressure to the fermentation system to perform forced compaction and exhaust and performing physical sealing, so that the system performs second-stage anaerobic fermentation until the pH value drops to a preset acidic range, and fermented feed is prepared. The process conversion triggered by one-time inoculation and natural temperature rise avoids the introduction of external miscellaneous bacteria by segmented inoculation, and a low-oxygen high-acidity environment is constructed through microbial metabolites and physical sealing.

The invention relates to the technical field of animal health, in particular to a microbial metabolite for reducing metritis and a screening method and application thereof. According to the invention, metritis of laying fowls, which is obtained by researching microorganisms related to metritis of broiler breeding chickens, is caused by complex interaction of age-related inflammatory response, microbial flora imbalance and tryptophan metabolism disorder. On the basis of 16sRNA gene sequencing, high performance liquid chromatography-mass spectrometry and other methods, a specific metabolite indole-3-acetaldehyde is screened out, and the model animal verifies that the indole-3-acetaldehyde is applied to treatment or prevention of body metritis.

The invention belongs to the technical field of biological medicine and tumor immunotherapy, and discloses application of 3-oxo-valproic acid coenzyme A in preparation of a medicine for inhibiting lung adenocarcinoma. As a specific agonist of GIMAP1, the 3-oxo-valproic acid coenzyme A is used for activating the GIMAP1, enhancing inhibition of lung cancer cell progress and enhancing activation of a tumor immune microenvironment, so that the lung adenocarcinoma is inhibited, and the lung adenocarcinoma is inhibited. The invention has the following beneficial effects: 1, strong targeting property: 3-oxo-valproate coenzyme A is specifically combined with GIMAP1, so that a mediated immunomodulatory pathway is accurately activated, and wide influence on normal cells is avoided; 2, immune microenvironment remodeling: the anti-tumor immune cell infiltration is remarkably improved, the lung adenocarcinoma immunosuppression microenvironment is reversed, and the immunotherapy sensitivity is improved; 3, tumor progression is inhibited, lung cancer cell proliferation is effectively inhibited, and the tumor invasion ability is reduced; 4, the source is natural: as an intestinal microbial metabolite derivative, the safety is high, and the side effect is lower than that of a chemically synthesized medicine.