318 results about "Antifungal" patented technology

The invention provides a cyclic peptide as well as a preparation method and application thereof. The cyclic peptide has an amino acid sequence # imgabs0 # represented by formula (1) (wherein X is a Lys residue modified with a fatty acid molecule, and a line connecting Arg and Lys represents an amide bond. The cyclic peptide prepared by the invention has wide antifungal activity and antibacterial activity on drug-resistant bacteria; meanwhile, the biotoxicity and the protease degradation resistance are high, and the in-vivo antibacterial effect of the cyclopeptide can be prolonged. The cyclic peptide can be applied to preparation of anti-bacterial and anti-fungal infection drugs, and can be used as an excellent substitute drug or an auxiliary drug of existing antibiotics. The method for preparing the cyclic peptide is simple, raw materials are easy to obtain, and industrial production can be achieved.

The present invention relates to a fungicidal composition comprising components (A) and (B), wherein components (A) and (B) are as defined in claim 1; and the use of the composition in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.

The invention relates to the technical field of antibacterial peptides, in particular to application of an antibacterial peptide RV-18-ack in preparation of an antifungal product. The antibacterial peptide RV-18-acy disclosed by the invention comprises a polypeptide RV-18 of which the amino acid sequence is shown as SEQ ID NO. 1. The antibacterial peptide RV-18-ack is a polypeptide capable of forming an amphiphilic alpha helical structure, can form nanoparticles in a self-assembly manner, has broad-spectrum antifungal activity, can damage fungal cell membranes in a targeted manner to play a bactericidal role, shows a relatively good antibacterial role on candida albicans, has the minimum inhibitory concentration of 2.344-75 mu M, and is free of cytotoxicity and hemolysis; besides, the antibacterial peptide RV-18-ack contains 18 amino acids, and all the amino acids are L-type amino acids, so that the production cost is greatly reduced, and the antibacterial peptide RV-18-ack is expected to become a novel broad-spectrum antifungal candidate drug and has a good application prospect in the aspect of resisting super fungi.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.

The invention relates to three antibacterial peptides and application thereof in resisting fungi and / or inducing plant immunity. Specifically, on one hand, the invention provides three antibacterial peptides which are novel functional antibacterial peptides ZJUAMP1, ZJUAMP2 and ZJUAMP65, the sequences of the novel functional antibacterial peptides ZJUAMP1, ZJUAMP2 and ZJUAMP65 are respectively shown as SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3, and the novel functional antibacterial peptides have good antifungal activity, can activate an MAPK signal channel in a plant body and induce the plant to generate systematic disease resistance, and are suitable for the fields of crop disease prevention and control and plant protection. The two antibacterial peptides are simple in structure and easy to synthesize. On the other hand, the invention further provides application of the two antibacterial peptides in resisting fungi, activating a plant MAPK signal channel, inducing plant immune response, enhancing plant disease resistance and / or preventing and treating plant diseases.

The invention discloses a chitosan composite temperature-sensitive gel microsphere for vaginal administration and a preparation method thereof, and relates to the technical field of biological medicines.The preparation method comprises the steps that high-purity chitosan and a temperature-sensitive polymer are mixed, then a cross-linking agent is dropwise added in a gradient mode to form pre-gel, after medicine is ultrasonically embedded, spraying or micro-fluidic forming is conducted, and the chitosan composite temperature-sensitive gel microsphere is obtained; carrying out surface modification and freeze drying by using a stabilizing aid to obtain microspheres; the system is composed of a chitosan matrix, a poly N-isopropylacrylamide temperature-sensitive polymer, a sodium tripolyphosphate cross-linking agent, an antifungal / antiviral / hormone drug and a hydroxypropyl methyl cellulose stabilizing aid, the particle size of microspheres is 50-300 [mu] m, the microspheres are rapidly gelatinized at 37 DEG C, the half-life period of the drug is longer than 8 h, the adhesive force is improved by 30% or above, and the residence time is prolonged to 12 h or above. According to the invention, by constructing a temperature-sensitive interpenetrating network structure and performing surface functional modification, body temperature triggered in-situ gelation, long-acting slow release and strong adhesion synergism are realized, and the local treatment effect and patient compliance are remarkably improved.

Provided are: an antifungal agent composition for hard surfaces, which has excellent persistence of the effect of suppressing the occurrence of discoloration (particularly blackening) caused by fungi such as mildew on hard surfaces; and a method for cleaning hard surfaces using the antifungal agent composition. This antifungal agent composition for hard surfaces contains the following component (a), component (b), component (c) and water, the mass ratio (c) / (b) of the content of component (b) to the content of component (c) being 0.003-0.25, component (a): an antifungal agent, component (b): a foamable surfactant (however, component (a) is excluded), and component (c): a water-soluble polymer.

Provided are a non-ribosomal antifungal peptide MaAFP1, a preparation method therefor and a use thereof. The molecular formula of the antifungal peptide MaAFP1 is C41H74N18O12, wherein an amino acid sequence from the N-terminus to the C-terminus is (D)Arg-(L)Arg(OH)-(D)Orn-(L)Thr-(D)Orn-(L)Arg(OH)-(D)Tyr. Fermentation is performed by using Metarhizium anisopliae CQMa421, a fermentation broth is collected, and separation and purification are performed by means of ion exchange chromatography and high performance liquid chromatography so as to obtain the antifungal peptide MaAFP1. The structure of MaAFP1 is analyzed by comprehensively using an Edman degradation method, mass spectrometry, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and circular dichroism spectroscopy. By performing an in vitro bacteriostatic test, it is found that MaAFP1 has a good inhibitory effect on a variety of animal and plant pathogenic fungi, and has the value of the development of a novel antibacterial drug.

This invention belongs to the field of pharmaceutical chemistry, and specifically relates to a compound antifungal cream containing the traditional Chinese medicine ingredient tryptamine ketone and its application. The invention comprises the following components, with the following percentage content: stearic acid 10%~16%, glyceryl monostearate 3%~7%, liquid paraffin 5%~9%, tryptamine 0.1%~0.01%, terbinafine hydrochloride 0.00625%~0.000625%, glycerin 4%, triethanolamine 2%~6%, ethylparaben 0.5%, and the balance being purified water or distilled water. This invention is highly effective, low in toxicity, and exhibits low drug resistance.

The invention discloses a (-)-menthol group-containing nicotinamide derivative with antifungal activity as well as a preparation method and application thereof, and relates to the technical field of synthesis of agricultural chemicals. The derivative has a structure as shown in a general formula (I), in the formula, n is an integer from 1 to 5, and R1, R2, R3 and R4 are specific substituent groups. Through a molecular hybridization strategy, the (-)-menthol, the N-fatty acyl piperazine bridge and the nicotinamide fragment are covalently linked, and a compound with a brand new structure is created. A biological activity test shows that the series of compounds have remarkable inhibitory activity on various plant pathogenic fungi, especially sclerotinia sclerotiorum and valsa mali of apple trees, and are low in cytotoxicity. Molecular docking research proves that the action target of the gene is succinate dehydrogenase (SDH). The invention provides a valuable leading structure for developing novel SDHI bactericides.

The present invention relates to an antifungal composition comprising a Senna tora sprout extract or a fraction thereof as an active ingredient, wherein the Senna tora sprout extract or a fraction thereof or a compound isolated therefrom exhibits a photoreaction under light conditions of a wavelength of 400-528 nm. The antifungal composition of the present invention has a synergistic effect on antifungal activity upon irradiation with light having a wavelength of 400-528 nm.

The present application relates to the field of rice blast prevention, and particularly relates to an application of perphenazine in prevention and treatment of rice blast. At present, perphenazine has not been reported in literatures to be used for prevention and treatment of rice blast. The technical problem to be solved by the present application is to provide an application of perphenazine in prevention and treatment of rice blast. The present application proves the effect of perphenazine in inhibiting rice blast fungus through tests. With the increase of concentration, the vegetative growth of rice blast fungus is obviously inhibited. Under the interference of perphenazine at a certain concentration, the pathogenicity of rice blast fungus is almost completely lost. Therefore, perphenazine can be used as a new antifungal agent for prevention and treatment of rice blast.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The present invention relates to a salt-based antifungal powder platform formulation comprising a sodium salt and L-leucine as excipients to be formulated alongside an antifungal agent to obtain a salt-based antifungal powder formulation, wherein the sodium salt is at a concentration of 5% w / w or less and the L-leucine is at a concentration of 30% w / w.

A method to produce a mixture comprising poacic acid (X) and poacidiene (Y) and the resulting product-by-process. The method includes the steps of subjecting a solution of ferulic acid to a free-radical coupling reaction to yield an intermediate mixture comprising ferulic acid dehydrodimers and decarboxylating the intermediate mixture to yield a product mixture containing poacic acid (X) and poacidiene (Y).

Provided are an amphotericin B amide derivative and a use thereof. The amphotericin B amide derivative is as shown in formula (I). The compound has good antifungal activity, is effective against various fungi, has good water solubility, is adapted to be developed into an injection dosage form, has excellent metabolic stability in animals (such as mice, rats, dogs, and monkeys), has a long half-life period, can effectively reduce the frequency of administration, has weak inhibition on CYP enzymes, and has a low risk of drug interaction.

A method for identifying a patient who will or is at risk of liver function decline in response to therapy with an antibiotic and / or antifungal agent, the method comprising measuring ethanol, one or more sugar fermentation products (such as 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13 the concentration of ethanol, one or more sugar fermentation products, such as 2, 3-butanediol, and / or a direct ethanol biomarker, wherein the concentration of ethanol, one or more sugar fermentation products, such as 2, 3-butanediol, and / or a direct ethanol biomarker indicates that the patient will respond to therapy with an antibiotic and / or antifungal agent.

The present invention relates to an antifungal prodrug comprising an antifungal moiety linked to a trigger moiety by means of a self-immolative spacer. The trigger moiety is selected from a glycosyl residue and an oligosaccharide, stabilizing the self-immolative spacer and enabling cleavage by a pathogen hydrolase, preferably an extracellular glycosidase (EC 3.2.1). Upon cleavage of the trigger moiety by the pathogen hydrolase, the self-immolative spacer undergoes spontaneous degradation in order to release the antifungal moiety. The present invention further relates to pharmaceutical compositions comprising the prodrug and to the use thereof in the treatment of infectious diseases.

The invention relates to the technical field of metal surface protection materials, in particular to a composite antirust agent with mildew-proof and antirust performance and a preparation method thereof.The preparation method comprises the following steps that S1, 5-nitroisophthalic acid and metal oxide are subjected to a heating reaction, and a reaction mixture containing 5-nitroisophthalic acid salt is generated; s2, carrying out separation and purification; s3, drying treatment is carried out, and dry powder is obtained; s4, premixing with a mildew inhibitor, a corrosion inhibitor, an antioxidant and a silane coupling agent to obtain uniform composite powder; and S5, mixing the composite powder, a surfactant and an organic solvent to obtain a composite antirust agent finished product. According to the invention, a composite system composed of 5-nitroisophthalic acid zinc and a plurality of functional auxiliary agents is constructed, so that synchronous mildew-proof and rust-proof protection on the metal surface in a high-humidity environment and an environment where microorganisms are easy to breed is realized, and the coating stability and the long-term protection reliability are remarkably improved.

The invention discloses an antifungal peptide targeting fusarium oxysporum as well as a preparation method and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the polypeptide specifically bound with Fusarium oxysporum is obtained through screening, and the sequence of the polypeptide is WYHRSHPQWNHW; the antifungal peptide WY-66-10 is formed by hybridizing and fusing the targeted structural domain and the weak-activity antibacterial peptide 66-10, the antifungal peptide WY-66-10 can kill fusarium oxysporum in a targeted manner, the minimum inhibitory concentration is improved by 30 times or more compared with that of the original polypeptide 66-10, and the targeted antifungal peptide WY-66-10 still keeps relatively weak cytotoxicity and hemolytic activity at the concentration of 128 mu M, and can be used for preparing the antifungal peptide WY-66-10. The method has good application values of targeting specific microorganisms, saving antibacterial resources and maintaining micro-ecological balance.

The invention relates to the technical field of pesticide preparations, in particular to a preparation method of a propionate and oligosaccharin compounded soluble concentrate, which is realized by the following steps: firstly, preparing a mixed solvent; performing ultrasonic and nanometer grinding treatment on the propionate raw medicine, and dissolving the propionate raw medicine in the mixed solvent to obtain a propionate solution; then adding an oligosaccharin combination, and carrying out gradient stirring to obtain a compound stock solution; then, lentinan, a surfactant, a compound stabilizer and other assistants are sequentially added, secondary filtration is performed, and finally the volume is fixed to obtain a finished product. The problems that an existing compound preparation is poor in lipid-water compatibility, insufficient in extreme environment stability and weak in crop stress resistance adaptation are solved, synergism of antifungal, antiviral, cold-resistant, lodging-resistant and quality-improving and yield-increasing is achieved, the compound preparation is particularly suitable for crops such as rice and tobacco in cold regions, the process is compatible with an existing production line, and the compound preparation has wide application prospects.

Disclosed herein are compositions for topical treatment that can include a therapeutic agent (preferably a topical antimicrobial or antifungal agent such as efinaconazole, tavaborole, or ciclopirox), a non-volatile organic solvent (preferably natural or synthetic vitamin E or vitamin E acetate), and optionally an emollient (such as cholesterol). Also disclosed herein are methods of treating diseases or disorders (preferably as a disease or disorder of the nail, nail bed, or skin, such as onychomychosis) by topically administering compositions that can include a therapeutic agent, a non-volatile organic solvent, and optionally an emollient.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention relates to an application of a combined composition nanoparticle in preparation of a medicine for resisting fungal and bacterial infection. The active components of the combined composition nanoparticle are antibiotics and antibiotic adjuvants, the antibiotic adjuvant is tripterine or a pharmaceutically acceptable salt thereof. Compared with the prior art, the tripterine or the medicinal salt thereof and the antibiotics are prepared into the nanoparticles by utilizing a nanotechnology, so that the solubility of the fat-soluble antibiotics is effectively improved, the biocompatibility of the tripterine or the medicinal salt thereof is improved, and the tripterine or the medicinal salt thereof has an excellent effect in resisting fungal and bacterial infection. The tripterine or the medicinal salt thereof can enhance the antibacterial effect, especially the antifungal effect, of the antibiotics, increase the antibacterial sensitivity of the antibiotics and inhibit the occurrence of fungal or bacterial drug resistance.

The present invention discloses a benzamide derivative containing a thiocyanatopyrazole structure, a preparation method thereof and an application thereof. The structural formula of this benzamide derivative containing a thiocyanatopyrazole structure is as follows in general formula (I), #imgabs0# wherein, R1 is trifluoromethyl, difluoromethyl or methyl; R2 is hydrogen, methyl, methoxy, trifluoromethyl, trifluoromethoxy, fluorine, chlorine, bromine, cyano or a multi-substituted combination thereof substituted at different positions. The benzamide derivative containing a thiocyanatopyrazole structure prepared by the present invention has broad-spectrum antifungal and oomycete activities, and particularly shows significant inhibitory activities against Valsa mali and Phytophthora capsici, which provides a basis for the development of a novel fungicide with the benzamide derivative containing a thiocyanatopyrazole structure as an active ingredient.

Methods for treating, selecting a treatment, and monitoring a treatment for an inflammatory bowel disease in a patient in need are disclosed. Treatments include administering an antifungal compound. The method for selecting and monitoring a treatment includes detecting a biomarker indicative of an amount of the fungus Debaryomyces hansenii within the sample. The treatment is administered if the biomarker is above a threshold level and the biomarker may be monitored before and during treatment. Biomarkers include abundance of fungal DNA in the patient's gut microbiota and anti-fungal antibodies in the blood of the patient.

This invention discloses a pharmaceutical composition containing the natural products osthol and berberine, exhibiting synergistic antibacterial and antifungal effects. The effectiveness of osthol in synergistically enhancing the antibacterial activity of berberine was demonstrated through checkerboard minimum inhibitory concentration (MIC) tests, antifungal activity experiments, and in vitro bacterial growth curves. This invention provides a novel application of the combined use of osthol and berberine in antibacterial and antifungal treatments. This composition belongs to the category of traditional Chinese medicine compound preparations, offering a new treatment strategy for the clinical treatment of bacterial and fungal infectious diseases.

A system for the synthesis of zinc oxide nanoparticles (ZnO-NPs) comprising the steps of preparing an aqueous extract from Annona muricata leaves, adding the extract to an aqueous solution of zinc acetate dihydrate, adjusting the pH to approximately 8 with sodium hydroxide, stirring and heating the mixture at approximately 70 °C, and collecting and drying the resulting ZnO nanoparticles.

The invention features echinocandin class compounds. The compounds can be useful for the treatment of fungal infections.

The formulation is an antibacterial and antifungal ointment which comprises of oil of Raphanus sativa seeds, white wax and white petroleum jelly. The ointment acts as a potent antibacterial and antifungal agent and is especially effective against dermatophytes. In clinical trials the ointment was found to be effective, well tolerated and free from irritative and allergic reactions.