329 results about "Antimicrobial action" patented technology

The present invention relates to the technical field of coatings. Disclosed are a coating composition having mold-proof and antibacterial properties and a preparation method therefor. The coating composition comprises the following raw materials: an acrylic resin emulsion, a curing agent, a coalescing agent, a defoaming agent, and a leveling agent, wherein the acrylic resin emulsion is prepared from an acrylate monomer, a cross-linking agent, and fluorine-containing silicone oil by means of free radical polymerization under the action of an initiator. A gemini-type quaternary ammonium salt functional group in the structure of the cross-linking agent can enable the coating to have good mold-proof and antibacterial effects, the presence of the ether bond can enable the coating to have better adhesive force, and the presence of the fluorine-containing silicone oil can enable a coating film formed by curing the coating to have a super-hydrophobic surface, thereby avoiding surface moisture which promotes bacterial growth and reproduction, and endowing the coating with antifouling and self-cleaning effects. In addition, the silicon-oxygen bond in the silicone oil can effectively enhance the heat resistance of the coating, thereby facilitating further application of the coating in indoor decoration.

The present invention primarily relates to the use of use of one or more compound(s) selected from the group as defined herein in constituent (i) to improve the antimicrobial effect of one or more compound(s) selected from the group as defined herein in constituent (ii) and / or the use of one or more compound(s) selected from the group as defined herein in constituent (ii) to improve the antimicrobial effect of one or more compound(s) selected from the group as defined herein in constituent (i). Moreover, the present invention relates to the use of a mixture comprising or consisting of constituents (i) and (ii) as defined herein for providing an antimicrobial effect, preferably to a solid or liquid personal care product or to a semi-finished product. The present invention further relates to a process for improving the antimicrobial effect of one or more compound(s) as defined in step a) and / or of one or more compound(s) as defined in step b) and a process for antimicrobial stablilisation of a personal care product or a semi-finished product as defined herein. It also relates to a mixture comprising or consisting of constituents (i) and (ii) as defined herein, preferably wherein the total amounts of constituents (i) and (ii), respectively, contained in the mixture are such that constituent (i) synergistically improves the antimicrobial effect of constituent (ii) and / or that constituent (ii) synergistically improve(s) the antimicrobial effect of constituent (i).

The invention belongs to the technical field of genetic engineering, and particularly relates to an antibacterial peptide with antibacterial and antiviral effects and application and a product thereof. The amino acid sequence of the antibacterial peptide provided by the invention has the following general formula: X1GX2FX3FX4KKFX5LFX6X7SKVLK, x1 is M or has no amino acid; x2 is one of R, G and H; x3 is one of KS, KR, HR and HH; x4 is R or L; x5 is one of KK, HH and HK; x6 is RR or KK; and X7 is I or L. The antibacterial peptide disclosed by the invention has a relatively good antibacterial effect, and shows antiviral activity on HPV16 (Human Papilloma Virus 16) and HPV18 (Human Papilloma Virus 18). Good application prospects are shown in the preparation of antibacterial or antiviral products.

The invention relates to the technical field of marine antifouling materials, in particular to a modified polyurethane marine antifouling coating based on a metal pyridine structure and a preparation method. According to the modified polyurethane marine antifouling paint based on the metal pyridine structure, polyhydric alcohols and diisocyanate monomers with different molecular weights are subjected to condensation polymerization to obtain a polyurethane prepolymer; then reacting a diaminopyridine monomer or a dihydroxypyridine monomer with a metal ion compound to obtain a chain extender with a metal pyridine structure; finally, the marine antifouling paint is prepared through the reaction between the terminal amino or hydroxyl of the metal pyridine structure chain extender and the terminal isocyanate group of the polyurethane prepolymer, the metal pyridine structure is introduced into polyurethane, the mechanical performance of the marine antifouling paint is enhanced, the marine antifouling paint is endowed with the antibacterial effect through metal ion release, and the service life of the marine antifouling paint is prolonged. Adhesion and growth of marine fouling organisms can be effectively inhibited, and an efficient and durable solution is provided for development of a polyurethane marine antifouling coating.

The invention relates to the technical field of high polymer materials, and discloses an antibacterial polyethylene composite material which comprises the following raw materials: polyethylene, maleic anhydride grafted polyethylene, a composite antibacterial filler, furyl silicone rubber, an antioxidant, an ultraviolet light absorber, a plasticizer, a stabilizer and a lubricant. The composite antibacterial filler and the furyl silicone rubber are prepared to participate in the preparation process of the polyethylene composite material, so that the prepared polyethylene composite material has excellent antibacterial effect, corrosion resistance, wear resistance and toughness, also has a good hydrophobic effect, can effectively prevent bacterial erosion, and has a good antibacterial effect. The use requirements in the fields of medical instruments, food packaging and the like are met, and the service life is long.

The present invention belongs to the field of biomedicine, and specifically relates to an antimicrobial peptide derived from lactoferrin and its application. The antimicrobial peptide derived from lactoferrin, whose amino acid sequence is shown in any one of SEQ ID NOs: 1 to 98, has a broad-spectrum antimicrobial effect, especially significant antibacterial effect against Pseudomonas putida, Rhodococcus erythropolis, Bacillus subtilis, Malassezia furfur, Cryptococcus neoformans, and Candida albicans, and has great application value.

The invention relates to the technical field of polymer materials, and discloses a polymer antibacterial material and a preparation method thereof.The polymer antibacterial material is obtained by adding polyethylene, maleic anhydride grafted polyethylene and quaternary ammonium salt modified polyurethane into a twin-screw extruder, blending and extruding. In the extrusion process, a terminal hydroxyl group in quaternary ammonium salt modified polyurethane reacts with an anhydride group in maleic anhydride grafted polyethylene, so that the compatibility between the quaternary ammonium salt modified polyurethane and polyethylene is increased, and meanwhile, crosslinking is generated, so that the quaternary ammonium salt modified polyurethane and the maleic anhydride grafted polyethylene are connected more tightly, and the mechanical properties of the quaternary ammonium salt modified polyurethane and the maleic anhydride grafted polyethylene are improved. A quaternary ammonium salt group and a quaternary phosphonium salt group in the quaternary ammonium salt modified polyurethane have good antibacterial effects and have synergistic antibacterial effects. A silicon element, a phosphorus element and a triazine group in the quaternary ammonium salt modified polyurethane jointly form an antibacterial system, and a synergistic antibacterial effect is achieved.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

Despite the existence and deployment of a range of antimicrobial / disinfectant / sterilization technologies and products, transmission of infectious diseases remains a significant problem worldwide, continuing to cause hundreds of millions of infections and millions of deaths every year of both human beings and animals. State-of-the-art technologies suffer from several disadvantages including being discrete in space and time, being overly dependent on human skill and discipline, and in some cases having harmful side-effects to human health. This invention proposes a series of industrial grade antimicrobial product designs, and materials and methods to make them highly effective products that offer continuous antimicrobial action, with minimum dependence on human discipline and skill once deployed, and with no harmful side-effects.

The invention discloses an antibacterial nylon 6 material as well as a preparation method and application thereof, relates to the technical field of nylon materials, and solves the problem that the antibacterial property and the mechanical property of nylon are difficult to consider at the same time. The material has a structure shown as a formula (I), R1 and R2 are independently selected from one of C1-24 linear chain / branched chain aliphatic groups, substituted / unsubstituted C3-12 alicyclic hydrocarbon groups / C6-18 aryl groups / C7-30 aralkyl groups, or R1 and R2 on the same N and connected N form 5-7-membered saturated / unsaturated heterocyclic rings; and each E-group is independently selected from the structural general formula (II). Each R3 is independently selected from one of C1-24 linear chain / branched chain aliphatic groups, substituted / unsubstituted C3-12 alicyclic hydrocarbon groups, C6-18 aryl groups and C7-30 aralkyl groups; x is an integer selected from 1 to 18; m is equal to 0.01-0.50, and m + n is equal to 1. The antibacterial nylon 6 material has a broad-spectrum and efficient antibacterial effect, is lasting in antibacterial effect and excellent in mechanical property, and can be used for preparing textiles, daily necessities, building materials, packaging materials or panels. # imgabs0 #

The invention discloses toothpaste which is pasty and comprises an abrasive, a humectant, a foaming agent, water, a bacteriostatic agent povidone iodine, 0.5 wt%-5 wt% of magnesium carbonate particles and 5 wt%-15 wt% of chitosan.The toothpaste has the advantages that cross-linking points are formed through electrostatic attraction between a positively charged chitosan acid solution and negatively charged povidone iodine and silicon dioxide particles; the preparation method comprises the following steps: preparing chitosan by virtue of a sol-gel method so as to realize gelation of the chitosan, uniformly dispersing silicon dioxide particles, povidone iodine and magnesium carbonate nanoparticles in the chitosan gel to obtain pasty toothpaste with good performance, the pasty toothpaste has relatively good stability, and the gel structure can also be used as a carrier to load and slowly release povidone iodine, so that the antibacterial action time of the povidone iodine is prolonged, and long-acting antibacterial protection is provided. The toothpaste disclosed by the invention has a good cleaning effect and antibacterial performance, is suitable for more user groups, especially crowds with sensitive oral cavities, and has important market requirements and application prospects.

The invention relates to the technical field of antibacterial peptides, in particular to application of an antibacterial peptide RV-18-ack in preparation of an antifungal product. The antibacterial peptide RV-18-acy disclosed by the invention comprises a polypeptide RV-18 of which the amino acid sequence is shown as SEQ ID NO. 1. The antibacterial peptide RV-18-ack is a polypeptide capable of forming an amphiphilic alpha helical structure, can form nanoparticles in a self-assembly manner, has broad-spectrum antifungal activity, can damage fungal cell membranes in a targeted manner to play a bactericidal role, shows a relatively good antibacterial role on candida albicans, has the minimum inhibitory concentration of 2.344-75 mu M, and is free of cytotoxicity and hemolysis; besides, the antibacterial peptide RV-18-ack contains 18 amino acids, and all the amino acids are L-type amino acids, so that the production cost is greatly reduced, and the antibacterial peptide RV-18-ack is expected to become a novel broad-spectrum antifungal candidate drug and has a good application prospect in the aspect of resisting super fungi.

The invention belongs to the technical field of biological genetic engineering, and particularly relates to a polypeptide for promoting exocrine expression of a target protein, a biological material and application thereof, an antibacterial peptide fusion protein and a recombinant genetic engineering bacterium. As a signal peptide, the polypeptide provided by the invention further improves the exocrine expression efficiency and yield of the target protein; a contrast experiment verifies that compared with the existing signal peptide, the optimized and modified signal peptide has the advantage that the efficiency of exocrine expression of target protein of a constructed lactococcus lactis expression system is improved by 2.1-13.6 times. The recombinant genetically engineered bacterium constructed by the invention successfully realizes efficient exocrine expression of the antibacterial peptide by the lactococcus lactis, has the probiotic property of lactic acid bacteria and the antibacterial effect of the antibacterial peptide, can be directly orally taken or used as an additive to be applied to food and animal feed, and greatly saves the production and preparation cost of the antibacterial peptide.

The present invention relates to the technical field of oral medicine and oral medical products, and in particular to a targeted nano-enzyme antibacterial agent having an oral microbiota level adaptive regulation function and a preparation method therefor. Specifically, a nitrogen-doped zeolite imidazolate framework material is used as a carrier; a bimetallic monatomic nano-enzyme is prepared by means of a pyrolysis method; and an antibacterial peptide is used as a surface anchoring body and is modified on the surface of the nano-enzyme, so that a multifunctional nano-enzyme having a high targeting colonization ability, a high-efficiency antibacterial biofilm and an antibacterial effect is obtained. Also provided are a pharmaceutical composition, an antibacterial agent, and an oral care product containing the nano-enzyme.

The invention belongs to the technical field of pet products, and particularly discloses a novel anthelmintic based on fipronil drops, which can effectively reduce the bacterial or fungal infection caused by parasites on the body surface or skin of pets by combining the antibacterial effects of fipronil, citronella extract and tripterygium wilfordii. The fipronil can quickly kill parasites, the citronella extract can further reduce breeding and contact of the parasites through a repelling effect, so that the overall effect of the medicine is accelerated, the citronella extract further reduces the secondary infection risk caused by the parasites by inhibiting growth of bacteria, and the tripterine further reduces the secondary infection risk caused by the parasites by inhibiting pathogenic microorganisms of skin. Through the synergistic effect of multiple components, the development of drug resistance of parasites to a single component can be reduced.

A preparation method for a food nanofiber film having sustained-release antibacterial activity, and a use thereof, belonging to the technical field of food packaging films. A metal-organic framework material MIL-101(Fe) is used to encapsulate natural plant essential oils, while polylactic acid and polycaprolactone are used as film-forming substrates, to prepare a food nanofiber film capable of exerting a long-term and efficient antibacterial effect; by means of encapsulating highly volatile natural plant essential oils with MIL-101(Fe), the residence time of antibacterial substances in the top space of the packaging film can be extended, increasing the utilization of the essential oils and achieving long-lasting antibacterial effects. Moreover, MIL-101(Fe) has a specific surface area of 2865 m2 / g, which can greatly improve the encapsulation rate and sustained-release effect of the plant essential oils. At the same time, the film, prepared by electrospinning, has a high specific surface area, which is conducive to increasing the encapsulation rate of the plant essential oils. This preparation method is safe, environmentally friendly, simple to operate, and easy to promote and apply.

The invention discloses a preparation method of a cobalt ferrite manganese ferrite L-polylactic acid composite antibacterial bone scaffold, which comprises the following steps: growing manganese ferrite on the surface of cobalt ferrite in situ to prepare cobalt ferrite-manganese ferrite composite powder, and adding the prepared cobalt ferrite-manganese ferrite composite powder into ethanol to prepare a suspension; the preparation method comprises the following steps: preparing cobalt ferrite-manganese ferrite and poly-L-lactic acid composite powder, performing ultrasonic mixing with poly-L-lactic acid ethanol suspension, performing centrifugal drying to obtain the cobalt ferrite-manganese ferrite and poly-L-lactic acid composite powder, and finally performing selective laser sintering to obtain the cobalt ferrite-manganese ferrite / poly-L-lactic acid composite antibacterial bone scaffold. As a novel bone implant, the cobalt ferrite-manganese ferrite / poly-L-lactic acid composite antibacterial bone scaffold prepared by the invention can generate local high temperature and a large amount of active oxygen under the excitation of an alternating magnetic field, so that a good antibacterial effect is achieved.

The invention belongs to the technical field of external pharmaceutical compositions, and particularly relates to a temperature phase change microsphere antibacterial gel and a preparation method thereof. The gel is composed of three core components: temperature phase change microspheres, a composite antibacterial component and a carbomer matrix solution. The antibacterial component comprises carvacrol, oregano oil, cinnamyl aldehyde, citral, gallic acid and nano-silver, and aims to realize a broad-spectrum and efficient antibacterial effect. Hydrogel is prepared into microspheres (the phase change temperature is 33 DEG C) by utilizing a micro-fluidic chip technology, antibacterial components are wrapped in the microspheres, and then the temperature phase change microsphere antibacterial gel is compounded. When the gel is daily stored, the microspheres can realize long-time activity maintenance of antibacterial components and play a role in protecting the active components. When the gel is smeared on the skin surface, the human body temperature (36-37 DEG C) is higher than the phase change temperature (33 DEG C), the gel microspheres are subjected to phase change, sustained and controlled release of antibacterial components is achieved, and the better antibacterial effect is achieved.

The present disclosure relates to a sock or shoe cover having grip features comprising at least one antimicrobial agent. The plurality of grip features are arranged on a plantar surface contact face. Optionally, a plurality of antimicrobial dorsal grip features are arranged about a dorsal face of the sock or shoe cover. In certain embodiments, a sock body of the sock or shoe cover also has antimicrobial qualities. In a second aspect, a method of reducing or eliminating the transportation of microbes from footwear is provided.

The invention belongs to the technical field of biological medicine, and provides a multifunctional fusion peptide modified 3D printing Ti implant constructed by a fusion peptide platform and a preparation method and application thereof. The antibacterial peptide KR-12 and the adhesion peptide GFOGER are simultaneously loaded on the surface of the 3D printing titanium implant through the specific targeting peptide minTBP-1. The sequence of the fusion peptide platform is divided into four main components: bioactive polypeptide sequences KR-12 and GFOGER; a connection unit (Linker); a lysine residue; a specific anchoring group minTBP-1; the composite material has specific loading and slow release capabilities, and utilizes synergistic antibacterial and osteogenesis functions to cope with continuous challenges of implant infection and insufficient osseointegration in biomedical equipment. Meanwhile, sterilization and bone regeneration promotion are achieved, and the method is of great importance to bone healing and enhancement of bone combination around the implant. In addition to the antibacterial effect, the synergistic effect of the antibacterial peptide KR-12 and the adhesive peptide GFOGER can significantly promote osteogenesis of the BMSCs.

The invention discloses an antibacterial gel composite material as well as a preparation method and application thereof. The antibacterial gel composite material comprises photo-crosslinking hydrogel, and the photo-crosslinking hydrogel is coated with a drug-loaded mesoporous material; the drug-loaded mesoporous material comprises polydopamine, mesoporous biological ceramic and a growth factor which are arranged in sequence; the surface of the mesoporous biological ceramic is coated with polydopamine; growth factors are encapsulated in the mesoporous biological ceramic; the mesoporous biological ceramic is doped with metal ions with an antibacterial effect. According to the antibacterial gel composite material provided by the invention, in the composite material, mesoporous biological ceramic is coated with polydopamine, so that ionic products and doped antibacterial ions in drugs and biological ceramic can be slowly released, the burst release is relatively small, and stable release is realized; in addition, by regulating and controlling the doping amount of the antibacterial ions in the porous biological ceramic and the mass of the medicine loaded in the doped mesoporous biological ceramic, the release curve of the medicine and the ions can be effectively regulated and controlled.

The invention discloses a membrane-rupturing antibacterial peptide and application thereof. On the basis of an artificial intelligence screening method, a membrane-rupturing antibacterial peptide KLAKLLKLLLWAQNELDQKK is identified from a proteome of toads, the membrane-rupturing antibacterial peptide has three positive charges, and 50% of amino acid is hydrophobic amino acid. Through experimental tests, the antibacterial peptide can inhibit the growth of 10 different strains including gram negative strains and gram positive strains; meanwhile, the semi-maximum hemolysis concentration and the semi-maximum cytotoxicity concentration of the antibacterial peptide are both greater than 128 mu g / mL, and the antibacterial peptide has good biological safety. The antibacterial peptide plays an antibacterial role by destroying cell membranes, has the characteristic that the drug resistance of bacteria is not easily caused, and is an ideal development object of antibacterial drugs and antibacterial products such as disinfectants, detergents and feed additives.

The invention belongs to the technical field of functional fabrics, and provides an antibacterial self-cleaning microfiber suede fabric as well as a preparation method and application thereof. The method comprises the following steps: carrying out dipping treatment on the microfiber suede fabric in a 2-methylimidazole solution; and adding the antibacterial mixed solution into the 2-methylimidazole solution in which the microfiber suede fabric is impregnated for reaction, placing the microfiber suede fabric loaded with the Cu-coated ZIF-L nano material above the hydrophobic finishing agent, and performing deposition reaction to obtain the antibacterial self-cleaning microfiber suede fabric. In the antibacterial self-cleaning microfiber suede fabric provided by the invention, the Cu-coated ZIF-L nano material provides an antibacterial effect, and the hydrophobic finishing agent provides a self-cleaning function; the Cu-coated ZIF-L nano material can also increase the roughness of the surface of the microfiber suede fabric, then the Cu-coated ZIF-L nano material and the hydrophobic finishing agent have a synergistic effect, the hydrophobic effect of the surface of the fabric is improved through a lotus leaf-like structure, and the self-cleaning purpose is achieved.

Disclosed embodiments relate to wound care materials and methods that comprise a self-gelling composition, configured to form a gel upon contacting fluid. The self-gelling composition is a substantially homogeneous mixture, and comprises fluid-absorbent particles loaded with iodine-based antimicrobial agent, a dehydrated hydrogel powder, and a polymer base, configured to allow dispensing the self-gelling composition from a syringe or tube and to prevent the self-gelling composition from gelling prior to contacting fluid. The gel performs one or more of the following tasks during a wear time, when applied at the wound: absorbing fluid or exudate, releasing iodine-based antimicrobial agent, achieving antimicrobial activities at the wound, remaining structurally integral and cohesive, protecting the wound from exposure to microorganisms, and facilitating healing. After a wear time of at least three days, the gel can be removed in two pieces or less and leave less than 5% residue by weight.

The invention provides an ionic liquid antibacterial disinfectant, belongs to the technical field of medical preparations, and aims to solve the technical problem that chemical disinfectants are harmful to human bodies. The ionic liquid antibacterial disinfectant comprises an ionic liquid and deionized water, the proportion of the ionic liquid is 0.01%-100% by weight, and the proportion of the deionized water is 0%-99.99% by weight. The cation of the ionic liquid is imidazole, amine, piperidine or pyridine, and the anion of the ionic liquid is theophylline salt, mandelate, chlorine salt or dicyanide salt. The ionic liquid antibacterial disinfectant provided by the invention has a good sterilization effect, belongs to a novel antibacterial disinfectant which is non-volatile, non-irritant, healthy and environment-friendly, and has the characteristics of wide application scene, excellent sterilization effect, long antibacterial action time and environment friendliness.

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a thiadiazole tetranuclear copper complex with anti-tumor and antibacterial activity and a preparation method and application of the thiadiazole tetranuclear copper complex. The chemical formula of the complex is [Cu4 (C3H3S2N2) 2 (C3H4S2N2) 4], the complex is synthesized from ligand thiadiazole and CuX, X is I or Br, and copper in the obtained complex is + 1 valence. The complex shows a good cytotoxic effect on breast cancer cells MCF-7, is likely to play a toxic effect by inducing apoptosis, ferroptosis, copper death and other ways, has a good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of anti-tumor drugs with antibacterial properties.

The present invention relates to the technical field of dyes, and discloses a plant dye for silk fabrics and a preparation method thereof. The present invention is provided by adding turmeric dye, phellodendron dye, antibacterial liquid, quaternized chitosan and water into a stirrer, stirring at room temperature, and obtaining the plant dye for silk fabrics after the end. The antibacterial liquid and quaternized chitosan contain a large amount of quaternary ammonium salt groups, which play a good antibacterial role. The cardanol in the antibacterial liquid itself has a certain antibacterial effect, and synergistically antibacterial with the quaternary ammonium salt. The sulfur element contained in the antibacterial liquid can promote the dehydration of the polymer substrate into carbon during the heating process. This carbon layer can effectively isolate the contact between oxygen in the air and the polymer substrate, thereby achieving a flame retardant effect; the boron element can form a glassy coating covering the polymer when heated, and the coating can effectively isolate oxygen and heat, thereby protecting the internal polymer from further combustion, thereby achieving a flame retardant effect.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The application discloses a preparation method of honey-mediated silver nanoparticle / attapulgite composite antibacterial material, which comprises the following steps: dissolving natural honey in water to form a honey aqueous solution under stirring, dispersing attapulgite powder into the honey aqueous solution to obtain a uniform mixed solution, adding silver nitrate aqueous solution dropwise into the mixed solution, adjusting the pH of the mixed solution to 8-9, and continuously stirring the mixed solution at room temperature for 3-6 hours; and centrifuging, washing and drying the obtained product to obtain the silver nanoparticle / attapulgite composite antibacterial material. The active components in the honey are used as a reducing agent and a stabilizer, the silver nanoparticle / attapulgite composite antibacterial material is synthesized by one-step method, the preparation process is green, simple and efficient; the natural attapulgite is used as a carrier, on the one hand, the generation process of the silver nanoparticles is regulated, and the technical problem of effectively reducing the agglomeration of the silver nanoparticles is solved; and on the other hand, the biological activity is synergistically enhanced, so that the silver nanoparticles can play a more efficient antibacterial role and the application safety is improved.

The application discloses a silver / schiff base antibacterial material, a preparation method and application, and relates to the field of antibacterial materials.The silver / schiff base antibacterial material, the preparation method and the application are characterized in that, based on the large electron cloud density of the carbon-nitrogen double bond of the schiff base, silver ions in a silver nitrate solution are uniformly adsorbed on a schiff base base through the electrostatic adsorption principle; under the reduction of a reducing agent, the silver ions are reduced to nanosilver ions, and a silver / schiff base antibacterial material is obtained, in which nanosilver ions in the form of nanospheres are uniformly dispersed on the schiff base in the form of a thin sheet layer, thereby greatly improving the dispersibility of the nanosilver ions.The preparation method is simple, low in cost, and capable of batch production, and has no cytotoxicity, and has high antibacterial effects on streptococcus, pseudomonas aeruginosa and staphylococcus aureus, and has a good application prospect.