181 results about "Antimicrobial action" patented technology

The invention relates to the technical field of marine antifouling materials, in particular to a modified polyurethane marine antifouling coating based on a metal pyridine structure and a preparation method. According to the modified polyurethane marine antifouling paint based on the metal pyridine structure, polyhydric alcohols and diisocyanate monomers with different molecular weights are subjected to condensation polymerization to obtain a polyurethane prepolymer; then reacting a diaminopyridine monomer or a dihydroxypyridine monomer with a metal ion compound to obtain a chain extender with a metal pyridine structure; finally, the marine antifouling paint is prepared through the reaction between the terminal amino or hydroxyl of the metal pyridine structure chain extender and the terminal isocyanate group of the polyurethane prepolymer, the metal pyridine structure is introduced into polyurethane, the mechanical performance of the marine antifouling paint is enhanced, the marine antifouling paint is endowed with the antibacterial effect through metal ion release, and the service life of the marine antifouling paint is prolonged. Adhesion and growth of marine fouling organisms can be effectively inhibited, and an efficient and durable solution is provided for development of a polyurethane marine antifouling coating.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

A preparation method for a food nanofiber film having sustained-release antibacterial activity, and a use thereof, belonging to the technical field of food packaging films. A metal-organic framework material MIL-101(Fe) is used to encapsulate natural plant essential oils, while polylactic acid and polycaprolactone are used as film-forming substrates, to prepare a food nanofiber film capable of exerting a long-term and efficient antibacterial effect; by means of encapsulating highly volatile natural plant essential oils with MIL-101(Fe), the residence time of antibacterial substances in the top space of the packaging film can be extended, increasing the utilization of the essential oils and achieving long-lasting antibacterial effects. Moreover, MIL-101(Fe) has a specific surface area of 2865 m2 / g, which can greatly improve the encapsulation rate and sustained-release effect of the plant essential oils. At the same time, the film, prepared by electrospinning, has a high specific surface area, which is conducive to increasing the encapsulation rate of the plant essential oils. This preparation method is safe, environmentally friendly, simple to operate, and easy to promote and apply.

The present disclosure relates to a sock or shoe cover having grip features comprising at least one antimicrobial agent. The plurality of grip features are arranged on a plantar surface contact face. Optionally, a plurality of antimicrobial dorsal grip features are arranged about a dorsal face of the sock or shoe cover. In certain embodiments, a sock body of the sock or shoe cover also has antimicrobial qualities. In a second aspect, a method of reducing or eliminating the transportation of microbes from footwear is provided.

Disclosed embodiments relate to wound care materials and methods that comprise a self-gelling composition, configured to form a gel upon contacting fluid. The self-gelling composition is a substantially homogeneous mixture, and comprises fluid-absorbent particles loaded with iodine-based antimicrobial agent, a dehydrated hydrogel powder, and a polymer base, configured to allow dispensing the self-gelling composition from a syringe or tube and to prevent the self-gelling composition from gelling prior to contacting fluid. The gel performs one or more of the following tasks during a wear time, when applied at the wound: absorbing fluid or exudate, releasing iodine-based antimicrobial agent, achieving antimicrobial activities at the wound, remaining structurally integral and cohesive, protecting the wound from exposure to microorganisms, and facilitating healing. After a wear time of at least three days, the gel can be removed in two pieces or less and leave less than 5% residue by weight.

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a thiadiazole tetranuclear copper complex with anti-tumor and antibacterial activity and a preparation method and application of the thiadiazole tetranuclear copper complex. The chemical formula of the complex is [Cu4 (C3H3S2N2) 2 (C3H4S2N2) 4], the complex is synthesized from ligand thiadiazole and CuX, X is I or Br, and copper in the obtained complex is + 1 valence. The complex shows a good cytotoxic effect on breast cancer cells MCF-7, is likely to play a toxic effect by inducing apoptosis, ferroptosis, copper death and other ways, has a good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of anti-tumor drugs with antibacterial properties.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The application discloses a preparation method of honey-mediated silver nanoparticle / attapulgite composite antibacterial material, which comprises the following steps: dissolving natural honey in water to form a honey aqueous solution under stirring, dispersing attapulgite powder into the honey aqueous solution to obtain a uniform mixed solution, adding silver nitrate aqueous solution dropwise into the mixed solution, adjusting the pH of the mixed solution to 8-9, and continuously stirring the mixed solution at room temperature for 3-6 hours; and centrifuging, washing and drying the obtained product to obtain the silver nanoparticle / attapulgite composite antibacterial material. The active components in the honey are used as a reducing agent and a stabilizer, the silver nanoparticle / attapulgite composite antibacterial material is synthesized by one-step method, the preparation process is green, simple and efficient; the natural attapulgite is used as a carrier, on the one hand, the generation process of the silver nanoparticles is regulated, and the technical problem of effectively reducing the agglomeration of the silver nanoparticles is solved; and on the other hand, the biological activity is synergistically enhanced, so that the silver nanoparticles can play a more efficient antibacterial role and the application safety is improved.

The application discloses a silver / schiff base antibacterial material, a preparation method and application, and relates to the field of antibacterial materials.The silver / schiff base antibacterial material, the preparation method and the application are characterized in that, based on the large electron cloud density of the carbon-nitrogen double bond of the schiff base, silver ions in a silver nitrate solution are uniformly adsorbed on a schiff base base through the electrostatic adsorption principle; under the reduction of a reducing agent, the silver ions are reduced to nanosilver ions, and a silver / schiff base antibacterial material is obtained, in which nanosilver ions in the form of nanospheres are uniformly dispersed on the schiff base in the form of a thin sheet layer, thereby greatly improving the dispersibility of the nanosilver ions.The preparation method is simple, low in cost, and capable of batch production, and has no cytotoxicity, and has high antibacterial effects on streptococcus, pseudomonas aeruginosa and staphylococcus aureus, and has a good application prospect.

The invention discloses a rolling method for an antibacterial titanium alloy plate, relating to the technical field of titanium alloy materials. An antibacterial agent, modified chitosan and guar gum are mixed, glycerol is used as a plasticizer, and ammonium tripolyphosphate is used as a cross-linking agent to prepare an antibacterial coating, which is then coated on the surface of the titanium alloy. The alkylated chitosan has a long hydrophobic chain and is tightly cross-linked with the guar gum under the cross-linking action of sodium tripolyphosphate, thereby synergistically improving the hydrophobic effect of the coating and blocking the adhesion of moisture and bacteria. Silver nanoparticles are evenly dispersed on the surface of montmorillonite. Through the effective combination of the two antibacterial effects, the antibacterial effect of the coating is fully exerted, while also protecting the titanium alloy plate and improving its corrosion resistance.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The invention relates to a veterinary hoof disease prevention and treatment composition as well as a preparation method and application thereof, and aims to solve the technical problems that existing commercial hoof bath lotion is limited in sterilization effect and relatively strong in local irritation, and a safe and efficient treatment medicament for treating cow hoof warts is lacked and the like. The invention provides a veterinary composition which comprises the following active ingredients: a glycyrrhizic acid compound, didecyl methyl ammonium bromide and polyhexamethylene guanidine salt, and the three components are combined, so that the composition has an antibacterial effect and an effect of promoting skin tissue repair at the same time. A series of tests prove that the traditional Chinese medicine composition can effectively inhibit animal pathogenic bacteria, prevent and / or treat animal limb and foot diseases and promote healing and repairing of ulcer injury. The medicament disclosed by the invention is suitable for preventing and treating limb and hoof diseases in a large-scale pasture, has the characteristics of high sterilization efficiency, good safety and effective treatment, and can improve the animal hoof health management level.

The invention relates to a dental and / or oral care product comprising between 0.0039% and 0.0078% by weight of nisin establishing and / or maintaining a pH of at least 4.5 in situ. Although said rather low nisin concentration does not provide an anti-bacterial effect, it is surprisingly and advantageously capable of maintaining stable pH values of at least 4.5, thereby preventing destruction of a subject's teeth enamel based on enamel demineralization effects at pH below 4.5, and said low nisin concentration advantageously further avoids dysbacteriosis, i.e. the oral microflora remains balanced, thus not leading to an increase of e.g. periodontitis associated bacteria.

The invention provides a polyolefin master batch with antibacterial and antioxidant functions and application, and belongs to the technical field of plastics. The polyolefin master batch is prepared from the following components in percentage by mass: 92 to 99 percent of polyolefin, 1 to 5 percent of titanium dioxide embedded tea polyphenol nano microspheres and 0 to 3 percent of modified nano zinc oxide. Through the structural design of the titanium dioxide embedded tea polyphenol nano-microspheres, the structure of the internal tea polyphenol is protected, in the use process, the tea polyphenol can be slowly released to achieve a continuous anti-oxidation effect, and the added nano-zinc oxide can form a heterojunction structure with the titanium dioxide embedded tea polyphenol nano-microspheres, so that the oxidation resistance of the tea polyphenol nano-microspheres is improved. The anti-ultraviolet capacity is enhanced while the antibacterial effect is achieved, and the multifunctional polyolefin master batch with the antioxidant, antibacterial and anti-ultraviolet functions is formed after the polyolefin master batch is blended with polyolefin.

Despite the existence and deployment of a range of antimicrobial / disinfectant / sterilization technologies and products, transmission of infectious diseases remains a significant problem worldwide, continuing to cause hundreds of millions of infections and millions of deaths every year of both human beings and animals. State-of-the-art technologies suffer from several disadvantages including being discrete in space and time, being overly dependent on human skill and discipline, and in some cases having harmful side-effects to human health. This invention proposes a series of industrial grade antimicrobial product designs, and materials and methods to make them highly effective products that offer continuous antimicrobial action, with minimum dependence on human discipline and skill once deployed, and with no harmful side-effects. Methods may include either or both first and second materials be formed by vapor or solution-based coating schemes and many may be antimicrobial in nature. Nanopores and / or nanotubes produce an ultra-high anti-microbially active surface area.

The utility model relates to the technical field of in-vitro positioning patches, and discloses a bacteriostatic medical image in-vitro positioning patch which comprises a lower layer, two bacteriostatic mechanisms, two sensors, two embedded cylinders and three large sticky pieces, an upper layer is fixedly arranged on the upper end face of the lower layer, a bottom layer and a breathable layer are arranged in the lower layer, and the breathable layer is fixedly arranged on the upper end face of the lower layer. A surrounding adhesive sheet is fixedly arranged at the completion position of the lower end face of the lower layer, the two bacteriostatic mechanisms comprise two outer frames, two bacteriostatic materials and four clamping blocks, and a plurality of taper holes are formed in the upper end faces of the two bacteriostatic mechanisms. According to the utility model, the bacteriostatic material is arranged in the bacteriostatic mechanism, the bacteriostatic material is made of silver ions, and nano-silver has excellent antibacterial performance and can continuously release the silver ions when being in contact with water or moisture, so that the antibacterial effect of the nano-silver is exerted; and the volatilization layers above and below the antibacterial material can prevent the antibacterial material from quickly volatilizing, so that the antibacterial effect of the positioning patch is better.

The application belongs to the technical field of genetic engineering, and particularly relates to an antibacterial peptide with antibacterial and antiviral effects, application and product thereof. The amino acid sequence of the antibacterial peptide has the following general formula: X1GX2FX3FX4KKFX5LFX6X7SKVLK; X1 is M or no amino acid; X2 is one of R, G and H; X3 is one of KS, KR, HR and HH; X4 is R or L; X5 is one of KK, HH and HK; X6 is RR or KK; and X7 is I or L. The antibacterial peptide has good antibacterial effect, and shows antiviral activity to HPV16 and HPV18. The antibacterial peptide shows good application prospect in preparation of antibacterial or antiviral products.

The present invention relates to hydrogels suitable for medical use—especially in wound treatment. The hydrogels contain a metal complex as active ingredient and display excellent antimicrobial action against biofilms. Furthermore, the hydrogels assure an excellent release of moisture and create optimal prerequisites for a rapid healing process even in the case of infected wounds. Further aspects of the invention relate to a process for producing the hydrogels and to wound dressings that contain the hydrogel as a constituent.

This invention belongs to the field of algae preservation technology, specifically relating to a chitosan-based nano-preservative for spirulina preservation and its preparation method. The preparation method of the chitosan-based nano-preservative includes the following steps: (1) adding eugenol and zinc acetate sequentially to a tannic acid solution, mixing well, and then ultrasonically treating at 35-45℃ for 2-6 hours to obtain a nanosphere system; (2) adding the nanosphere system obtained in step (1) to a chitosan solution, then adding zinc acetate to the chitosan solution, and stirring and reacting at 25-60℃ for 8-12 hours to obtain the chitosan-based nano-preservative. This invention achieves a multi-effect combination of "antibacterial-antioxidant-slow release" through the synergistic effect of the antibacterial action of eugenol, the antioxidant / anti-inflammatory action of tannic acid, and the auxiliary antibacterial and cross-linking action of zinc acetate, thus solving the problem of the functional limitations of single preservation technology.

The present invention relates to a wound contact layer which is suitable for wound care. The wound contact layer comprises a mesh-like substrate which is partially or completely coated with an emulsion, wherein the emulsion comprises an antimicrobial composition containing a) ionic silver and / or silver nitrate, b) ionic zinc and / or zinc nitrate, and c) EDTA. The wound contact layer has an antimicrobial effect and is effective against biofilms. The wound contact layer enables wound care and promotes wound healing.

The present invention relates to a bio-based microbial retardant composition and a method of preparation thereof The composition comprises lactic acid (2-20% v / v), glutaraldehyde (0.5-10% v / v), Polysorbate 80 (Tween 80) (1-15% v / v), Melia Azadirachta Seed Oil (Neem oil) (0.05-5.5% v / v), and Methylchloroisothiazolinone (Preservative DB20) (0.01-1% v / v). This composition is designed to maintain an acidic pH of 1.5 to 3.5, ensuring immediate microbial retardation. The lactic acid stabilizes the glutaraldehyde, preventing polymerization, while Polysorbate 80 emulsifies Neem oil to enhance antimicrobial action. The preservative inhibits initial microbial contamination, providing immediate suppression of microbial load. The composition is readily biodegradable, exhibiting over 70% degradation within 28 days and is capable of broad-spectrum antimicrobial activity, effective against gram-negative bacteria, fungi, and algae. The composition shows sustained antimicrobial efficacy across multiple generations without inducing resistance. A method of preparing the composition is also provided, involving a sequence of mixing steps for optimal performance.

The invention discloses a cotton / lyocell composite material for a face towel and a preparation method of the cotton / lyocell composite material, and relates to the technical field of textile fabrics. The cotton fibers and the lyocell fibers are pretreated to form the cotton / lyocell composite fiber net, and then the cotton / lyocell composite fiber net is soaked in the hydrophilic antibacterial finishing agent, so that the cotton / lyocell composite fiber net has the characteristics of being soft, hydrophilic, antibacterial and the like. The hydrophilic antibacterial finishing agent comprises modified polyamide and modified organosilicon quaternary ammonium salt; the modified polyamide contains ether bonds, hydroxyl groups and carboxyl groups and has good hydrophilicity; the modified organosilicon quaternary ammonium salt is further grafted with a compound beta-cyclodextrin inclusion compound, tea polyphenol is included in a cavity of beta-cyclodextrin through a cavity structure of beta-cyclodextrin, then nano-silver is loaded on the surface of beta-cyclodextrin through electrostatic interaction, the antibacterial effect is enhanced through the synergistic effect of nano-silver, tea polyphenol and quaternary ammonium salt, beta-cyclodextrin can efficiently include odor molecules, and the odor removal effect is improved. And a good deodorization effect is achieved.

The present invention discloses a method for producing multi-stage disinfected and aseptically packaged medical cotton swabs. In the present invention, the antimicrobial agent is prepared through a sophisticated process to ensure uniform dispersion and stable bonding of nanosilver particles to the cotton swab material, maximizing the beneficial effects of the antimicrobial agent. This carefully designed formula provides sustained antimicrobial action. The large specific surface area of ​​the nanosilver particles ensures ample contact with microorganisms, rapidly killing or inhibiting their growth. The addition of triclosan and quaternary ammonium salts enhances the antimicrobial spectrum, making it effective against a variety of pathogens. During the preparation process, a sustained-release carrier effectively controls the release rate of the antimicrobial agent, ensuring that the antimicrobial agent continues to work over an extended period. The sustained-release carrier allows the antimicrobial agent to be slowly released from the surface or interior of the cotton swab, maintaining its antimicrobial effect over a longer period of time, reducing the need for frequent replacement of disinfectant products and enhancing the stability of the antimicrobial agent.

The solid formulation (tablet) prepared from a specific liquid mixture containing bacteriophages and endolysins active against the important pathogens Staphylococcus aureus and Pseudomonas aeruginosa as active ingredients is therapeutically applicable and dose-stable for the treatment of infections caused by these antibiotic-resistant pathogens. It also allows the bacteriophages and their enzymes to be maintained and stored at relatively high temperatures and other conditions that are unfavorable for these active ingredients.

The present invention belongs to the field of pharmaceutical chemistry technology, and in particular relates to novel coumarin-containing pyrrolo[2,3-d]pyrimidine derivatives, their preparation methods, and applications. The present invention provides a class of novel coumarin-containing pyrrolo[2,3-d]pyrimidine derivatives, the present invention relates to compounds having structural formula (I), and further relates to pharmaceutically acceptable salts, solvates, and prodrugs thereof. The present invention also relates to pharmaceutical compositions containing compounds of structural formula (I) and their pharmaceutical uses. These compounds have pharmacological activities such as antitumor, antiviral, anti-inflammatory, and antibacterial effects and are used to treat related diseases.

The application discloses a kind of photothermal-photodynamic synergistic antibacterial multifunctional probe and its preparation method and application, and is related to biomedical antibacterial field.The antibacterial probe includes gold-silver alloy hollow nanoparticles and photosensitizer modified on the surface of the gold-silver alloy hollow nanoparticles, and the photosensitizer for photodynamic antibacterial effect is chlorin e6 (Ce6).The antibacterial probe in the application has simple synthesis steps, excellent photothermal properties and photodynamic effect, has a significant effect on antibacterial growth, and has good biocompatibility, and can be used for the skin surface of animal tissue to carry out antibacterial effect.

The present invention consists of the use of cyclic oligosaccharides as modulators of the activity of antiseptic active ingredients, causing a synergistic effect in antimicrobial compositions; more specifically, the present invention presents the ability of cyclic oligosaccharides to alter or modulate the spectrum of antimicrobial activity of an antiseptic active ingredient, enabling efficacy against microorganisms against which the active ingredient is not effective in its isolated form or increasing its efficacy against fungi, resistant microorganisms, such as resistant fungi, and microorganism biofilms. The present invention also presents the novelty of a composition that hinders the development of resistant microorganisms and / or eliminates resistant microorganisms, thanks to the specific characteristic of the cyclic oligosaccharide and the slow and continuous release of the antiseptic active ingredient. For resistant microorganism biofilms, the prolonged antiseptic action obtained has a significant impact on combating the complex defences created by biofilms.

The invention discloses an application of micafungin in preparation of a medicine for inhibiting fungi, and an application of micafungin and trifloxystrobin combined medicine in preparation of a medicine for inhibiting fungi, especially an inhibition effect on magnaporthe oryzae. Research finds that micafungin has an inhibition effect on magnaporthe oryzae. Micafungin and trifloxystrobin are combined for use and have a synergistic effect, so that the drug resistance of the trifloxystrobin drug-resistant magnaporthe oryzae can be overcome, and the antibacterial effect on the magnaporthe oryzae is improved. Research finds that micafungin has a broad-spectrum antifungal effect and also has an inhibition effect on botrytis cinerea, fusarium moniliforme, linseed fungus and other fungi besides the inhibition effect on magnaporthe oryzae.