112 results about "Antimicrobial action" patented technology

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

A preparation method for a food nanofiber film having sustained-release antibacterial activity, and a use thereof, belonging to the technical field of food packaging films. A metal-organic framework material MIL-101(Fe) is used to encapsulate natural plant essential oils, while polylactic acid and polycaprolactone are used as film-forming substrates, to prepare a food nanofiber film capable of exerting a long-term and efficient antibacterial effect; by means of encapsulating highly volatile natural plant essential oils with MIL-101(Fe), the residence time of antibacterial substances in the top space of the packaging film can be extended, increasing the utilization of the essential oils and achieving long-lasting antibacterial effects. Moreover, MIL-101(Fe) has a specific surface area of 2865 m2 / g, which can greatly improve the encapsulation rate and sustained-release effect of the plant essential oils. At the same time, the film, prepared by electrospinning, has a high specific surface area, which is conducive to increasing the encapsulation rate of the plant essential oils. This preparation method is safe, environmentally friendly, simple to operate, and easy to promote and apply.

The present disclosure relates to a sock or shoe cover having grip features comprising at least one antimicrobial agent. The plurality of grip features are arranged on a plantar surface contact face. Optionally, a plurality of antimicrobial dorsal grip features are arranged about a dorsal face of the sock or shoe cover. In certain embodiments, a sock body of the sock or shoe cover also has antimicrobial qualities. In a second aspect, a method of reducing or eliminating the transportation of microbes from footwear is provided.

Disclosed embodiments relate to wound care materials and methods that comprise a self-gelling composition, configured to form a gel upon contacting fluid. The self-gelling composition is a substantially homogeneous mixture, and comprises fluid-absorbent particles loaded with iodine-based antimicrobial agent, a dehydrated hydrogel powder, and a polymer base, configured to allow dispensing the self-gelling composition from a syringe or tube and to prevent the self-gelling composition from gelling prior to contacting fluid. The gel performs one or more of the following tasks during a wear time, when applied at the wound: absorbing fluid or exudate, releasing iodine-based antimicrobial agent, achieving antimicrobial activities at the wound, remaining structurally integral and cohesive, protecting the wound from exposure to microorganisms, and facilitating healing. After a wear time of at least three days, the gel can be removed in two pieces or less and leave less than 5% residue by weight.

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a thiadiazole tetranuclear copper complex with anti-tumor and antibacterial activity and a preparation method and application of the thiadiazole tetranuclear copper complex. The chemical formula of the complex is [Cu4 (C3H3S2N2) 2 (C3H4S2N2) 4], the complex is synthesized from ligand thiadiazole and CuX, X is I or Br, and copper in the obtained complex is + 1 valence. The complex shows a good cytotoxic effect on breast cancer cells MCF-7, is likely to play a toxic effect by inducing apoptosis, ferroptosis, copper death and other ways, has a good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of anti-tumor drugs with antibacterial properties.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The application discloses a preparation method of honey-mediated silver nanoparticle / attapulgite composite antibacterial material, which comprises the following steps: dissolving natural honey in water to form a honey aqueous solution under stirring, dispersing attapulgite powder into the honey aqueous solution to obtain a uniform mixed solution, adding silver nitrate aqueous solution dropwise into the mixed solution, adjusting the pH of the mixed solution to 8-9, and continuously stirring the mixed solution at room temperature for 3-6 hours; and centrifuging, washing and drying the obtained product to obtain the silver nanoparticle / attapulgite composite antibacterial material. The active components in the honey are used as a reducing agent and a stabilizer, the silver nanoparticle / attapulgite composite antibacterial material is synthesized by one-step method, the preparation process is green, simple and efficient; the natural attapulgite is used as a carrier, on the one hand, the generation process of the silver nanoparticles is regulated, and the technical problem of effectively reducing the agglomeration of the silver nanoparticles is solved; and on the other hand, the biological activity is synergistically enhanced, so that the silver nanoparticles can play a more efficient antibacterial role and the application safety is improved.

The application discloses a silver / schiff base antibacterial material, a preparation method and application, and relates to the field of antibacterial materials.The silver / schiff base antibacterial material, the preparation method and the application are characterized in that, based on the large electron cloud density of the carbon-nitrogen double bond of the schiff base, silver ions in a silver nitrate solution are uniformly adsorbed on a schiff base base through the electrostatic adsorption principle; under the reduction of a reducing agent, the silver ions are reduced to nanosilver ions, and a silver / schiff base antibacterial material is obtained, in which nanosilver ions in the form of nanospheres are uniformly dispersed on the schiff base in the form of a thin sheet layer, thereby greatly improving the dispersibility of the nanosilver ions.The preparation method is simple, low in cost, and capable of batch production, and has no cytotoxicity, and has high antibacterial effects on streptococcus, pseudomonas aeruginosa and staphylococcus aureus, and has a good application prospect.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The invention relates to a veterinary hoof disease prevention and treatment composition as well as a preparation method and application thereof, and aims to solve the technical problems that existing commercial hoof bath lotion is limited in sterilization effect and relatively strong in local irritation, and a safe and efficient treatment medicament for treating cow hoof warts is lacked and the like. The invention provides a veterinary composition which comprises the following active ingredients: a glycyrrhizic acid compound, didecyl methyl ammonium bromide and polyhexamethylene guanidine salt, and the three components are combined, so that the composition has an antibacterial effect and an effect of promoting skin tissue repair at the same time. A series of tests prove that the traditional Chinese medicine composition can effectively inhibit animal pathogenic bacteria, prevent and / or treat animal limb and foot diseases and promote healing and repairing of ulcer injury. The medicament disclosed by the invention is suitable for preventing and treating limb and hoof diseases in a large-scale pasture, has the characteristics of high sterilization efficiency, good safety and effective treatment, and can improve the animal hoof health management level.

The invention provides a polyolefin master batch with antibacterial and antioxidant functions and application, and belongs to the technical field of plastics. The polyolefin master batch is prepared from the following components in percentage by mass: 92 to 99 percent of polyolefin, 1 to 5 percent of titanium dioxide embedded tea polyphenol nano microspheres and 0 to 3 percent of modified nano zinc oxide. Through the structural design of the titanium dioxide embedded tea polyphenol nano-microspheres, the structure of the internal tea polyphenol is protected, in the use process, the tea polyphenol can be slowly released to achieve a continuous anti-oxidation effect, and the added nano-zinc oxide can form a heterojunction structure with the titanium dioxide embedded tea polyphenol nano-microspheres, so that the oxidation resistance of the tea polyphenol nano-microspheres is improved. The anti-ultraviolet capacity is enhanced while the antibacterial effect is achieved, and the multifunctional polyolefin master batch with the antioxidant, antibacterial and anti-ultraviolet functions is formed after the polyolefin master batch is blended with polyolefin.

Despite the existence and deployment of a range of antimicrobial / disinfectant / sterilization technologies and products, transmission of infectious diseases remains a significant problem worldwide, continuing to cause hundreds of millions of infections and millions of deaths every year of both human beings and animals. State-of-the-art technologies suffer from several disadvantages including being discrete in space and time, being overly dependent on human skill and discipline, and in some cases having harmful side-effects to human health. This invention proposes a series of industrial grade antimicrobial product designs, and materials and methods to make them highly effective products that offer continuous antimicrobial action, with minimum dependence on human discipline and skill once deployed, and with no harmful side-effects. Methods may include either or both first and second materials be formed by vapor or solution-based coating schemes and many may be antimicrobial in nature. Nanopores and / or nanotubes produce an ultra-high anti-microbially active surface area.

The present invention relates to hydrogels suitable for medical use—especially in wound treatment. The hydrogels contain a metal complex as active ingredient and display excellent antimicrobial action against biofilms. Furthermore, the hydrogels assure an excellent release of moisture and create optimal prerequisites for a rapid healing process even in the case of infected wounds. Further aspects of the invention relate to a process for producing the hydrogels and to wound dressings that contain the hydrogel as a constituent.

This invention belongs to the field of algae preservation technology, specifically relating to a chitosan-based nano-preservative for spirulina preservation and its preparation method. The preparation method of the chitosan-based nano-preservative includes the following steps: (1) adding eugenol and zinc acetate sequentially to a tannic acid solution, mixing well, and then ultrasonically treating at 35-45℃ for 2-6 hours to obtain a nanosphere system; (2) adding the nanosphere system obtained in step (1) to a chitosan solution, then adding zinc acetate to the chitosan solution, and stirring and reacting at 25-60℃ for 8-12 hours to obtain the chitosan-based nano-preservative. This invention achieves a multi-effect combination of "antibacterial-antioxidant-slow release" through the synergistic effect of the antibacterial action of eugenol, the antioxidant / anti-inflammatory action of tannic acid, and the auxiliary antibacterial and cross-linking action of zinc acetate, thus solving the problem of the functional limitations of single preservation technology.

The invention discloses a cotton / lyocell composite material for a face towel and a preparation method of the cotton / lyocell composite material, and relates to the technical field of textile fabrics. The cotton fibers and the lyocell fibers are pretreated to form the cotton / lyocell composite fiber net, and then the cotton / lyocell composite fiber net is soaked in the hydrophilic antibacterial finishing agent, so that the cotton / lyocell composite fiber net has the characteristics of being soft, hydrophilic, antibacterial and the like. The hydrophilic antibacterial finishing agent comprises modified polyamide and modified organosilicon quaternary ammonium salt; the modified polyamide contains ether bonds, hydroxyl groups and carboxyl groups and has good hydrophilicity; the modified organosilicon quaternary ammonium salt is further grafted with a compound beta-cyclodextrin inclusion compound, tea polyphenol is included in a cavity of beta-cyclodextrin through a cavity structure of beta-cyclodextrin, then nano-silver is loaded on the surface of beta-cyclodextrin through electrostatic interaction, the antibacterial effect is enhanced through the synergistic effect of nano-silver, tea polyphenol and quaternary ammonium salt, beta-cyclodextrin can efficiently include odor molecules, and the odor removal effect is improved. And a good deodorization effect is achieved.

The application discloses a kind of photothermal-photodynamic synergistic antibacterial multifunctional probe and its preparation method and application, and is related to biomedical antibacterial field.The antibacterial probe includes gold-silver alloy hollow nanoparticles and photosensitizer modified on the surface of the gold-silver alloy hollow nanoparticles, and the photosensitizer for photodynamic antibacterial effect is chlorin e6 (Ce6).The antibacterial probe in the application has simple synthesis steps, excellent photothermal properties and photodynamic effect, has a significant effect on antibacterial growth, and has good biocompatibility, and can be used for the skin surface of animal tissue to carry out antibacterial effect.

The invention discloses an application of micafungin in preparation of a medicine for inhibiting fungi, and an application of micafungin and trifloxystrobin combined medicine in preparation of a medicine for inhibiting fungi, especially an inhibition effect on magnaporthe oryzae. Research finds that micafungin has an inhibition effect on magnaporthe oryzae. Micafungin and trifloxystrobin are combined for use and have a synergistic effect, so that the drug resistance of the trifloxystrobin drug-resistant magnaporthe oryzae can be overcome, and the antibacterial effect on the magnaporthe oryzae is improved. Research finds that micafungin has a broad-spectrum antifungal effect and also has an inhibition effect on botrytis cinerea, fusarium moniliforme, linseed fungus and other fungi besides the inhibition effect on magnaporthe oryzae.

The invention belongs to the technical field of coating materials, and particularly relates to a hydrophilic antibacterial mildew-proof agent, a synthesis method thereof, a mildew-proof antibacterial hydrophilic coating and application thereof. The preparation raw materials comprise thymol and glycidyl methacrylate. According to the hydrophilic antibacterial and mildew-proof agent provided by the invention, thymol with antibacterial performance is grafted with glycidyl methacrylate, and double bonds in the hydrophilic antibacterial and mildew-proof agent provide active sites for subsequent reaction with acrylic resin and a curing agent; a cross-linking reaction with acrylic resin and a curing agent in the coating can be carried out to form a cross-linked structure with an antibacterial effect; the cross-linked structure can also improve the stability and mechanical properties of the coating, and can still maintain the structural integrity in a complex environment, thereby continuously playing an antibacterial role and effectively inhibiting the growth of various moulds and bacteria.

The present invention relates to kits, methods and systems for modulating free iodine in PVP-I, facilitating antimicrobial action while also ensuring compatibility with diagnostic assays.

The application discloses a plasma modified polyurethane medical dressing and a preparation method and application thereof, and relates to the technical field of medical dressings. The polyurethane sponge is cleaned and dried, and then is treated by using a plasma technology in an oxygen atmosphere to obtain treated polyurethane sponge; then, recombinant collagen with a HIS tag is prepared into a recombinant collagen solution; then, metal ions with antibacterial effects are added into the solution; the treated polyurethane sponge in step S1 is contacted with the recombinant collagen solution; finally, the modified polyurethane medical dressing is immersed into a high-molecular solution with a low isoelectric point and a negative charge under a neutral condition, and the medical dressing is obtained after drying and washing after immersion. The preparation method avoids the use of chemical cross-linking agents, ingeniously uses the tag of the recombinant collagen, simplifies an antibacterial substance loading process, and enables the antibacterial agent not to be excessive, so that the antibacterial agent can be used for a long time at a wound and can be safely applied to the fields of negative pressure drainage and wound care.

The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

This invention discloses a sponge photothermal interface evaporation device with antibacterial properties, its preparation method, and its application. The sponge photothermal interface evaporation device includes a photothermal layer and a water supply layer arranged vertically, with the photothermal layer laid on top of the water supply layer. The photothermal layer is printing paper modified with CPTS solution. The CPTS solution includes the following components by weight: 0.03–0.07 parts nano-titanium dioxide particles, 0.15–0.35 parts carbon nanotubes, 0.08–0.18 parts polyvinyl alcohol, 0.04–0.10 parts sodium dodecyl sulfate, and 20–30 parts deionized water. The water supply layer is obtained by modifying a sponge by soaking it in a 10–25 g / L tea polyphenol aqueous solution. This invention innovatively applies tea polyphenols to the preparation of interface evaporation materials through sponge modification. Tea polyphenols exert antibacterial functions on the one hand, and on the other hand, act as a hydrophilic modifier to enhance the hydrophilicity of the sponge material itself, thereby improving the efficiency of interface evaporation.

The application relates to a mildew-proof cotton yarn and a manufacturing process thereof; the mildew-proof cotton yarn is treated by a surface treatment agent which comprises isonitrosamine, 4,6-dihydroxy-2-cyanamino pyrimidine, glacial acetic acid, carboxymethyl chitosan, isopropyl alcohol and water and the like. The isonitrosamine, 4,6-dihydroxy-2-cyanamino pyrimidine and glacial acetic acid are reacted together to generate a long-carbon-chain guanidine compound, which can destroy bacterial cell membranes and cause the death of bacteria; the cotton yarn is mainly composed of cotton fibers containing cellulose, the cellulose contains a large amount of hydroxyl groups, and the guanidine organic matter generated by the isonitrosamine, 4,6-dihydroxy-2-cyanamino pyrimidine and glacial acetic acid introduces a polar hydroxyl group, thereby the affinity with the cotton yarn can be improved, on one hand, the antibacterial groups are introduced into the cotton fibers of the cotton yarn, on the other hand, the surface treatment agent is attached to the cotton yarn so that the antibacterial agent is left on the surface of the cotton yarn, thereby the antibacterial property of the cotton yarn is improved in multiple aspects, and a good antibacterial effect is achieved.

The invention relates to a method for preparing an antibacterial Jianshui purple pottery product by impregnating a biscuit, which comprises the following steps of: mixing and stirring 10-30 parts of cerium nitrate or cerium acetate, 50-300 parts of manganese nitrate or manganese acetate, 10-50 parts of zinc nitrate or zinc acetate and 300-500 parts of deionized water to obtain a mixed solution; then biscuiting the prepared and formed Jianshui purple pottery clay blank; immersing the biscuit-fired green body into the mixed solution, taking out the green body after the green body adsorbs the mixed solution for 24-48 hours, naturally airing or drying at the temperature lower than 100 DEG C, and firing the green body; the oxidizing atmosphere is kept in the firing process, and after firing is finished, the temperature of the furnace is reduced to the normal temperature, and the Jianshui purple pottery product with the antibacterial effect is prepared. The method adapts to the characteristics and preparation technology of the Jianshui purple pottery pug, and the prepared Jianshui purple pottery product is good in antibacterial property.

This invention provides a household reverse osmosis composite membrane and its preparation method. The preparation method includes preparing a hybrid hydrogel layer, preparing a hybrid aerogel layer, and preparing a polyamide functional layer to obtain the household reverse osmosis composite membrane. This household reverse osmosis composite membrane is prepared using this method. This invention can prepare a household reverse osmosis composite membrane with high water flux and desalination rate, and also has antibacterial properties and can improve the taste of purified water.

The invention belongs to the technical field of organic compounds, and particularly relates to an organic compound with antibacterial activity and a preparation method and application thereof. The organic compound provided by the invention has a structure as shown in a formula 1, a formula 2 or a formula 3. The organic compound provided by the invention has antibacterial activity, and the stenolnate C, the stenolnate H and the stenolnate I are various types of organic compounds, have activity on candida albicans, and show a relatively good antibacterial effect. The organic compound provided by the invention is a metabolite of Sterium sanguinol HF-41 and is prepared through microbial fermentation, the preparation method is short in period, mild in culture condition, few in by-products and low in cost, large-scale industrial production is easy to realize, and the requirements of modern environmental protection and low-carbon economy are met. .

The invention provides a chlorine dioxide slow-release composition. The chlorine dioxide slow-release composition comprises a component A, a component B and a component C, the component A comprises sodium chlorite, a first high-molecular compound and water; the first high-molecular compound comprises one or more of polyvinyl alcohol, polyethylene glycol and polyacrylamide; the component B comprises organic acid, a second high-molecular compound and water; the second high-molecular compound comprises genipin or sodium alginate; the component C comprises a cross-linking agent and water, and the cross-linking agent is chlorate. In the sustained-release composition provided by the invention, the sodium chlorite is wrapped in the first high-molecular compound capable of forming the hydrogel, and then is mixed with the organic acid, the second high-molecular compound and the cross-linking agent to form a cross-linking product wrapping the organic acid, so that the sodium chlorite and the organic acid react along with degradation of the hydrogel and the cross-linking product; and chlorine dioxide gaseous molecules are slowly and continuously released, so that the antibacterial action period of a coating formed by the composition is prolonged.

The invention discloses a plasma modified polyurethane medical dressing and a preparation method and application thereof.The preparation method comprises the steps that polyurethane sponge is cleaned and then dried, then the polyurethane sponge is treated in the oxygen atmosphere through the plasma technology, the treated polyurethane sponge is obtained, recombinant collagen with an HIS tag is prepared into a recombinant collagen solution, and the plasma modified polyurethane medical dressing is obtained. The preparation method comprises the following steps: preparing a polyurethane sponge solution, adding metal ions with an antibacterial effect into the solution, contacting the polyurethane sponge treated in the step S1 with a recombinant collagen solution, finally immersing the modified polyurethane medical dressing into a polymer solution which is low in isoelectric point and has negative charges under a neutral condition, and drying and washing to obtain the medical dressing after the infiltration is completed. According to the preparation method, the use of a chemical cross-linking agent is avoided, meanwhile, the tag of the recombinant collagen is ingeniously utilized, the antibacterial substance loading process is simplified, and the antibacterial agent is not excessive, can be used at a wound for a long time, and can be safely applied to the fields of negative pressure drainage, wound surface nursing and the like.

The present application relates to the field of ship cabin decoration coatings, further relates to a coating with antibacterial effect and its preparation method and application. The coating of the present application is added with a visible light photocatalyst antibacterial agent. After the coating is applied on the surface of the ship cabin, the visible light photocatalyst antibacterial agent produces antibacterial and bacteriostatic effects through electron transition under visible light irradiation. Under non-irradiation conditions, the visible light photocatalyst antibacterial agent restores to its original state, thereby achieving long-acting and safe antibacterial effect. Furthermore, the technical problem of "unable to achieve long-acting antibacterial effect (short antibacterial effect maintenance time)" existing in the prior art antibacterial cabin coating is solved.

The present application has an object to provide an antibacterial iron powder which is inexpensive and has excellent antibacterial action. The antibacterial iron powder of one embodiment of the present application contains metallic iron as a main component.