85 results about "Bone scaffold" patented technology

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.

The invention discloses a 3D printing self-adaptive control system for bone defect, and relates to the technical field of 3D printing self-adaptive control, a miniaturized optical coherence tomography, a high-resolution camera, a force sense and temperature sensor and the like are installed on an operation site, and the whole process of material deposition and solidification is monitored; then, deviation is rapidly recognized through an anomaly detection and error prediction model, defect positions are output, and a closed-loop control unit is combined with model prediction control and self-adaptive path planning to achieve online adjustment of key variables such as the extrusion amount and the printing speed; when the defect cannot be made up automatically through parameter adjustment, the system can trigger local shutdown and secondary repair, the forming quality is evaluated through multi-modal scanning and a repair scoring function after repair, and the high matching degree and mechanical stability of the final bone scaffold and the bone defect part are ensured; the cooperation of multi-modal sensing and local path planning enables the system to have higher adaptability.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The application discloses a lateral flow fishbone-shaped inclined plate assembly and an inclined plate sedimentation tank. The inclined plate assembly comprises a fishbone support, an inclined plate connecting piece and an inclined plate. The inclined plate is in the form of a flat plate. The mounting portion of the inclined plate connecting piece is in the form of a long and thin plate and is arranged in an inclined manner. The upper end of the inclined plate is mounted on the mounting portion. An extension portion is arranged on the lower side of the mounting portion. A washing assembly for washing the inclined plate is mounted on the lower end of the extension portion. The fishbone support is arranged in a vertical arrangement. A plurality of pairs of inclined plate connecting pieces are arranged along the length direction of the fishbone support. Each pair of inclined plate connecting pieces is oppositely arranged on the two sides of the fishbone support. Each pair of inclined plate connecting pieces is connected with the fishbone support through the connecting portion thereof. The lower end of the mounting portion is inclined towards the direction away from the fishbone support. The application adopts a unique inclined plate structure and a fishbone-shaped inclined plate assembly, and is provided with a washing assembly for effectively washing the inclined plate. The application effectively increases the allowable length of the inclined plate while ensuring the structural stability of the inclined plate assembly and the inclined plate module, reduces the maintenance interval, and improves the sedimentation effect.

The invention relates to the technical field of cancellous bone scaffolds, and discloses a topological optimization-based cancellous bone scaffold reverse generation model determination method and device, in the method, a three-dimensional thin layer structure is subjected to topological optimization processing, and complex and irregular microstructure characteristics of cancellous bone tissues can be simulated. The first multi-channel mechanical nephogram and the second multi-channel mechanical nephogram are force-related features. And multi-modal data composed of the three-dimensional thin-layer structure, the initial simplified model, the first multi-channel mechanical cloud picture and the second multi-channel mechanical cloud picture is used as a training sample to train a potential map diffusion model, so that the model can obtain strong performance of outputting a cancellous bone scaffold result under the training of a multi-modal input condition.

The application provides a alginate-based aerogel, a preparation method and application thereof. The alginate-based aerogel has parallelly arranged large pores and oriented channels at an angle with the large pores, and the angle ranges from 0 to 180 degrees. The large pores are distributed in the same direction inside the alginate-based aerogel, and the oriented channels improve the interconnectivity between the large pores. The existence of the large pores and the oriented channels makes the alginate-based aerogel have the characteristics of anisotropy and a multi-scale pore structure, and the size of the large pores and the oriented channels is suitable for inducing vascularization and osteogenesis. Therefore, the aerogel can be used as a bone scaffold material. Tests show that the aerogel has the characteristics of light weight and high strength. In addition, other components beneficial to osteogenesis can be added in the alginate system, and the size of the pores can be adjusted without affecting the formation of the pore structure.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention relates to the technical field of bone scaffold materials, and discloses a preparation method and application of a pre-vascularized bone repair scaffold, the preparation method of the pre-vascularized bone repair scaffold comprises the following steps: firstly, obtaining a porous scaffold and carrying out sulfonation treatment to obtain a sulfonated scaffold; then preparing a mixed solution containing gelatin and an extracellular matrix, and adding mesenchymal stem cells and / or endothelial cells to obtain a cell mixed preparation; and finally, contacting the cell mixed preparation with the sulfonated scaffold, and culturing to obtain the sulfonated scaffold. The pre-vascularized bone repair scaffold prepared by the preparation method disclosed by the invention simultaneously has excellent angiogenesis promoting capability and osteogenesis induction characteristic in vitro, and realizes vascularization-ossification synergistic interaction through a positive feedback loop mediated by a paracrine signal network; and a new thought and a new method are expected to be developed for clinical application of large-segment bone defect repair.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.

The invention discloses a preparation method of porous ceramic with a non-uniform fusion structure, which comprises the following steps: step 1, constructing a fusion function, and determining parameters of the fusion function; 2, preparing a wax pattern negative template; step 3, preparing ceramic slurry; step 4, dipping and freezing; step 5, low-pressure drying; and 6, sintering to obtain the TPMS structure porous ceramic. The invention further discloses the porous ceramic with the non-uniform fusion structure. The invention further discloses application of the porous ceramic with the non-uniform fusion structure in the field of bionic bone scaffolds. According to the method, the fusion function is constructed by fusing the G-shaped function and the TPMS function, so that non-uniform fusion of various hole patterns is realized; the mode of wax negative template freezing casting and indirect forming is adopted, the design freedom degree of a complex structure is reserved, meanwhile, the problems of resolution limitation, shrinkage deformation, supporting difficulty and the like during direct 3D printing of the porous ceramic are solved, and the use effect is good.

The invention discloses a preparation method and application of a functional degradable soybean oil-based bionic porous composite bone scaffold. The method comprises the following steps: taking epoxidized soybean oil acrylate as a bio-based base material, compounding isobornyl methacrylate to improve the defects of high viscosity and low photosensitivity of the bio-based base material, adding a photoinitiator containing ethyl 2, 4, 6-trimethylbenzoyl phenyl phosphonate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide, compounding, and carrying out aging treatment to obtain base resin; mixing calcium lignosulphonate into the base resin to prepare composite photosensitive resin, and printing a triple-period extremely-small curved surface structure through a digital light processing technology and a 3D printing technology to finally obtain the functional degradable soybean oil-based bionic porous scaffold. The scaffold has calcium lignosulphonate-mediated controllable photo-thermal response behaviors of near-infrared light illumination regulation and bone scaffold component dependence under the condition of simulating the in-vivo environment of a human body, so that a controllable photo-thermal response-mediated remote shape memory function is realized, and meanwhile, a mild, safe and controllable photo-thermal curative effect can also be realized. Besides, calcium lignosulphonate promotes degradation of the composite scaffold by preferentially dissolving and generating a microporous structure on the surface of a matrix while improving the hydrophilic performance of the scaffold, and continuously releases calcium ions, so that the scaffold shows enhanced biomineralization ability and promotes cell proliferation and osteogenic differentiation. The research provides a solution with potential for the soybean oil-based biological photosensitive material in the digital light processing preparation technology and the multi-functional application of the bionic porous bone scaffold so as to deal with complex and irregular bone defects.

The application discloses a preparation method of non-uniform fusion structure porous ceramic, comprising the following steps: step one, constructing a fusion function and determining parameters of the fusion function; step two, preparing a wax negative template; step three, configuring ceramic slurry; step four, impregnating and freezing; step five, low-pressure drying; and step six, sintering, so as to obtain TPMS structure porous ceramic. The application also comprises non-uniform fusion structure porous ceramic. The application also comprises application of the non-uniform fusion structure porous ceramic in the field of biomimetic bone scaffolds. The application constructs a fusion function by fusing a G-shaped function and a TPMS function, realizes non-uniform fusion of various pore types, adopts a wax negative template freezing casting and an indirect forming mode, retains the design freedom of a complex structure, solves problems such as resolution limitation, shrinkage deformation and support difficulty that are faced by direct 3D printing of porous ceramic, and has good use effect.

The invention discloses a model construction method of a gradient random porous structure of a simulated bone trabecula, a white calendite piezoelectric bone scaffold and a preparation method of the white calendite piezoelectric bone scaffold, and the model construction method provided by the invention is a design method based on a Thiessen polygon porous structure with seed point release gradient change and volume scaling coefficient linear gradient change. In the body center scaling process, interpolation calculation is conducted on scaling coefficients from the axis to the outermost end in the cylindrical domain in the radial direction, and therefore the model of the stochastic gradient porous structure with the pore diameter decreasing from inside to outside in the radial direction and the pore edge diameter increasing from inside to outside in the radial direction is finally formed, by designing the formula and process parameters of the white calcium stone ceramic slurry, the possible problems of over-curing, cracking and the like are avoided, and the white calcium stone piezoelectric ceramic bone scaffold with excellent bonding performance is prepared by adopting a 3D printing photocuring printing technology.

The application claims a preparation method of a ceramic / polymer continuous gradient porous scaffold, and belongs to the technical field of biological tissue engineering bone scaffold. The porous scaffold structure adopts a three-period minimal surface (TPMS) design, and the scaffold structure and volume fraction are controllable. The continuous gradient material adopts a mixed slurry of different volume fractions of hydroxyapatite powder and photosensitive PLA resin as the material, and a gradient polylactic acid layer containing 0% to 30% of nano-hydroxyapatite is sequentially arranged from inside to outside. The high volume fraction of HA / PLA on the outside promotes cell adhesion and improves the bone ingrowth ability. The pure PLA scaffold is prepared by a 3D printing stereolithography forming method, the scaffold surface is activated by using a plasma cleaning process, the slurry with the ceramic material composition on the outer layer is attached to the scaffold surface by using a solution immersion method, the excess slurry in the pores is removed by using a centrifugal device, and ultraviolet light (wavelength range 360-410 nm) is used for irradiation and curing. The application uses a continuous gradient to overcome the shortcoming of the sharp change of the performance of the traditional composite material at the material interface, which leads to stratification.

The application discloses a SrCO3@ZIF-8 / polymer composite bone scaffold and a preparation method thereof, and comprises the following steps: growing zeolite imidazolate framework-8 (ZIF-8) on the surface of SrCO3 in situ to prepare SrCO3@ZIF-8 microrods, uniformly mixing the SrCO3@ZIF-8 microrods and a polymer material through grinding, and preparing the SrCO3@ZIF-8 / polymer composite bone scaffold by using a selective laser sintering technology. The SrCO3@ZIF-8 / polymer composite bone scaffold obtained by the application is applied to bone defect repair, and the Zn ions and Sr ions generated by in-vivo degradation of the scaffold can promote the differentiation of stem cells into osteoblasts, endow the scaffold with osteogenic activity, promote the polarization of macrophages into M2 type and the expression of related anti-inflammatory factors, and strengthen the anti-inflammatory performance of the scaffold. In addition, the ZIF-8 contains a large number of 2-methyl imidazole organic ligands, can form a strong interface with the molecular chain of the polymer, solves the problem of interface incompatibility between SrCO3 and the polymer, and thus improves the mechanical performance of the scaffold.

The invention provides a piezoelectric composite material compositely integrated by high-performance piezoelectric conductive hydrogel and a biphase bone scaffold. The piezoelectric composite material is formed by compositing piezoelectric hydrogel, conductive hydrogel and a tricalcium phosphate / hydroxyapatite biphase scaffold, the piezoelectric hydrogel is formed by wrapping glycine nanofibers with a modified polymer; the conductive hydrogel is formed by complexing a polymer solution containing lithium acetate, borate ions and a hydroxyl compound. The pressure-responsive self-generating composite material which is high in conductivity, high in voltage, high in support and biodegradable is formed by integrating the pressure-conductive hydrogel and the biphase bone scaffold, construction of a composite hydrogel system which is high in voltage, high in conductivity, high in support strength and biodegradable is achieved, and the application requirement of a high-performance bone repair material system is met.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.

The invention belongs to the technical field of bionic bone scaffolds, and particularly relates to a TPMS structure bionic bone scaffold with an immune regulation function and a preparation method of the TPMS structure bionic bone scaffold. Comprising the following steps: preparing a three-period extremely-small curved surface bionic scaffold and micro-tissues, loading micro-tissue spheres in a methacryloyl gelatin solution, then pouring the micro-tissue spheres into the three-period extremely-small curved surface bionic scaffold, and carrying out photo-crosslinking gel forming to obtain the three-period extremely-small curved surface structure bionic bone scaffold with the immune regulation and control function. The bionic bone scaffold disclosed by the invention can be used for accurately simulating components and structures of natural bones, has good immunoregulation and osteogenesis promoting capabilities, and is expected to cooperate with functionalized micro-tissues to construct an immune microenvironment and promote bone tissue regeneration.

A method for characterizing a bone tissue scaffold produced by an additive manufacturing process is provided. An image of the bone tissue scaffold is first captured and a boundary of the bone tissue scaffold is determined. One or more surface features of the bone tissue scaffold are subsequently detected using an edge detection algorithm, with the one or more surface features including one or more pores and / or one or more highlights. Edges that correspond to a pore using a pore filling algorithm are identified and the surface porosity of the bone tissue scaffold is thereby mapped. Systems for characterizing a bone tissue scaffold are also provided and make use of an image capture device for capturing an image of the bone tissue scaffold, as well as a processor for analyzing the image via instructions stored on the processor.

The present invention discloses a photothermal bone tumor scaffold with controlled drug release, as well as its preparation method and application. The scaffold has two sets of curved, independently connected channels, with the outer channel being open and connected, and the inner channel being closed and connected. The scaffold is made of a Ca2MgSi2O7 / ZTA composite ceramic material. The preparation process involves adding ceramic slurry to a photocuring printing device, performing photocuring printing based on a photothermal bone tumor scaffold model to produce a ceramic blank, performing secondary curing on the blank to produce a ceramic green body, and sintering the green body to obtain the photothermal bone tumor scaffold. The scaffold provided by the present invention has high porosity and strength, possesses an independent dual-channel structure, and integrates multiple functions: osteogenesis, controlled release of chemotherapy drugs, and photothermal killing of bone tumor cells.

The invention discloses a porous diamond reinforced polylactic acid composite bone scaffold and a preparation method thereof, and belongs to the technical field of biomedical implants. The stent is integrally formed through a selective laser sintering technology and is composed of a polylactic acid matrix and porous diamonds uniformly dispersed in the polylactic acid matrix, and the mass fraction of the porous diamonds is 2%-16%. The surface of the porous diamond is rich in porous structures and oxygen-containing functional groups, the porous diamond and a polylactic acid matrix form a molecular bonding and mechanical interlocking synergistic enhancement interface, and the mechanical property of the polylactic acid composite bone scaffold is remarkably improved. The preparation method comprises the following steps: (1) weighing polylactic acid powder and porous diamond powder according to a set proportion, and uniformly mixing through vacuum ball milling to obtain composite powder; and (2) performing selective laser sintering on the composite powder in an argon protective atmosphere, and integrally forming to obtain the composite bone scaffold. The problem that traditional diamond particle reinforced phase interface bonding is weak is solved, and the method has wide application prospects in the field of bone tissue engineering.

The application discloses a method for designing a bionic femur support based on lattice structure and TPMS structure fusion, and belongs to the technical field of bionic bone support. The application respectively creates a CAD model of a Diamond unit homogeneous porous structure and a CAD model of an Iso Truss unit homogeneous porous structure; a Ramp fusion function is created to fuse the Diamond unit homogeneous porous structure and the Iso Truss unit homogeneous porous structure to generate a preliminary ITD fusion CAD model; then the preliminary ITD fusion CAD model and a newly established cylinder III are fused by using a Boolean intersection instruction to form a final ITD fusion CAD model, finally, the final ITD fusion CAD model is divided into a finite element simulation grid model and an inp format simulation model file is output; the inp format simulation model file is imported into HyperMesh software to repair and divide a grid and an inp file format model is exported. The bionic bone support designed by the application has higher bearing capacity and stability, forms a mechanical property gradient, and is suitable for complex mechanical environments. Meanwhile, the bionic bone support can promote cell adhesion, proliferation and differentiation, transport nutrients, discharge metabolic waste, and improve cell survival rate.

Disclosed is a use of G007-LK in promoting osteogenic differentiation of dental mesenchymal stem cells and bone tissue regeneration. In vitro experiments of the present application show that G007-LK has the ability to induce SHED to form mineralized nodules and promote osteogenic differentiation; in vivo experiments show that G007-LK pretreatment of SHED for 7 days combined with Geistlich Bio-Oss® collagen bone scaffold can enhance the in vivo osteogenic effect of SHED and promote the subcutaneous ectopic osteogenesis of nude mice, indicating that G007-LK has good osteoinductivity and is a potential osteogenic drug. Therefore, G007-LK can promote osteogenic differentiation of dental mesenchymal stem cells and be applied to bone tissue regeneration.

The utility model relates to the technical field of medical instruments, in particular to a drug sustained-release cartilage support. The drug sustained-release cartilage stent comprises a plurality of support units which are overlapped in sequence, each supporting unit comprises two polygonal structures, and the two polygonal structures are connected in a three-dimensional mode through a plurality of parallel V-shaped connecting parts. And the polygonal structure is formed by connecting two groups of parallel V-shaped connecting parts end to end. The drug sustained-release cartilage stent can be compressed when being implanted, and rebounds after being implanted, so that mechanical support is realized. Meanwhile, triangular bulges or grooves are formed in the surface of the porous scaffold constructed by the V-shaped connecting parts, so that embedding with surrounding tissues is facilitated.

The invention relates to a bionic bone scaffold customized body and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention provides a preparation method of a bionic bone scaffold customized body, which comprises the following steps: scanning and recording a cranio-maxillofacial hard tissue defect form, and constructing a digital scaffold model through an algorithm model and / or artificial design based on the recorded data; performing three-dimensional reconstruction on the obtained digital scaffold model to generate bionic bone scaffold customized volume data meeting the personalized requirements of cranio-maxillofacial tissue defects; and converting the obtained customized body data of the bionic bone scaffold into a customized body of the bionic bone scaffold by utilizing a 3D printing technology. Modeling is conducted through real bone defect data, a bionic bone scaffold customized body of the bone defect part is prepared through the 3D printing technology, the outer contour is attached to the bone defect side form, the ideal bone form is reconstructed, the inner contour is a fine substructure of the defect part, and the bionic bone scaffold has a bionic pore structure and biomechanical performance; the method can be used for reconstructing personalized cranio-maxillofacial tissues.

This application relates to the technical field of cancellous bone scaffolds, and discloses a method and apparatus for determining a reverse generation model of cancellous bone scaffolds based on topology optimization. In this method, the three-dimensional thin-layer structure is topology optimized to mimic the complex and irregular microstructural features of cancellous bone tissue. The first and second multi-channel mechanical contour maps represent force-related features. Multimodal data consisting of the three-dimensional thin-layer structure, the initial simplified model, the first multi-channel mechanical contour map, and the second multi-channel mechanical contour map are used as training samples to train a latent graph diffusion model. This allows the model to achieve powerful output performance for cancellous bone scaffolds under multimodal input conditions.

The invention discloses a soybean oil-based composite bone scaffold with photo-thermal mediated shape memory and thermal therapy functions and a preparation method of the soybean oil-based composite bone scaffold. The method comprises the following steps: taking bio-based acrylated epoxidized soybean oil and polyethylene glycol diacrylate as a composite matrix, doping natural melanin nanoparticles as functional components into the composite matrix to prepare composite photosensitive resin, and finally preparing the porous scaffold through a digital light treatment 3D printing technology. Under irradiation of near-infrared light, the composite scaffold shows a controllable and efficient photo-thermal response behavior, and the target steady-state temperature can be achieved by adjusting the loading capacity and irradiation conditions of the natural melanin nanoparticles. On one hand, the photothermal effect can trigger shape memory recovery so as to realize minimally invasive implantation and shape self-adaptive filling of irregular bone defects. On the other hand, the composite scaffold shows an efficient photo-thermal inhibition effect (the inhibition rate exceeds 90%) on human osteosarcoma cells. In addition, the composite scaffold exhibits enhanced in vitro biomineralization ability. The invention provides a promising solution for designing and preparing a multifunctional bio-based 3D printing bone scaffold to cope with the challenge of complex bone defects.

The present application belongs to the technical field of biological scaffolds, and particularly relates to a preparation method of a porous biomimetic bone scaffold and the biomimetic bone scaffold. The preparation method of the porous biomimetic bone scaffold comprises the following steps: mixing a hydrogel main material, water, a crosslinking agent, an alkyl amine compound and an optional complex high polymer material; and performing directional freezing treatment on the obtained mixed product, wherein the hydrogel main material is selected from one or more than two of silk fibroin, collagen and gelatin, and the complex high polymer material is selected from one or more than two of hyaluronic acid, chitosan and other biological source natural polymer and synthetic organic high polymer compound. The porous biomimetic bone scaffold with certain pore size directional micropore channels and nanochannels formed along the side walls of the directional micropore channels can be prepared by the method.

The invention belongs to the technical field of medical materials, and particularly relates to a drug-loaded porous magnesium alloy bone scaffold and a preparation method thereof.The drug-loaded porous magnesium alloy bone scaffold is prepared from, by mass, 55 parts of magnesium alloy, 6-10 parts of corrosion-resistant matter, 1 part of drug-loaded gel, 2-4 parts of antibacterial bone promoting matter and 3 parts of gelatin; the magnesium alloy is made into a micro tube, and the micro tube is filled with the drug-loaded hydrogel to realize drug sustained release; gelatin is sprayed on the surface, corrosion-resistant materials are attached through Mg-N coordinate bonds, hot pressing is carried out, and components of the corrosion-resistant materials and the gelatin form an interpenetrating network to enhance combination and react with the magnesium alloy to form a protective film. Meanwhile, Ca < 2 + > initiates crosslinking of sodium alginate to form a stable corrosion-resistant barrier; and finally, an antibacterial bone-promoting mixed solution containing modified chitosan and a temperature-sensitive polymer is sprayed, bone-promoting components are uniformly dispersed around the implant through a complex reaction and temperature control, and tissue compatibility is improved.

The invention discloses a lateral flow fishbone-shaped inclined plate assembly and an inclined plate sedimentation tank. The inclined plate assembly comprises a fishbone bracket, an inclined plate connecting piece and an inclined plate, the inclined plate is flat-plate-shaped; the mounting part of the inclined plate connecting piece is in a long thin plate shape and is obliquely arranged; the upper end of the inclined plate is mounted on the mounting part; an extension part is arranged on the lower side of the mounting part; a flushing assembly for flushing the inclined plate is mounted at the lower end of the extension part; the fishbone brackets are vertically arranged; a plurality of pairs of inclined plate connecting pieces are arranged in the length direction of the fishbone support, each pair of inclined plate connecting pieces are oppositely arranged on the two sides of the fishbone support and connected with the fishbone support through the connecting parts of the inclined plate connecting pieces, and the lower ends of the mounting parts incline in the direction away from the fishbone support. According to the invention, the unique inclined plate structure and the fishbone-shaped inclined plate assembly are adopted, and the flushing assembly is arranged to effectively flush the inclined plate, so that the permissible length of the inclined plate is effectively increased, the maintenance interval is reduced, and the precipitation effect is improved while the structural stability of the inclined plate assembly and the inclined plate module is ensured.