307 results about "Bone scaffold" patented technology

An integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of spiral coils with gaps of controlled width between the coils to provide an open geometry for enhanced cell growth. The spiral scaffold resides within the bore of the shell and is integrated with the shell to fix the geometry of the spiral scaffold. Nanofibers may be deposited on the porous sheet to enhance cell penetration into the spiral scaffold. The spiral scaffold may have alternating layers of polymer and ceramic on the porous sheet that have been built up using a layer-by-layer method. The spiral scaffold may be seeded with cells by growing a cell sheet and placing the cell sheet on the porous sheet before it is rolled.

Disclosed are porous ceramic balls with a hierarchical porous structure ranging in size from nanometers to micrometers, and preparation methods thereof. Self-assembly polymers and sol-gel reactions are used to prepare porous ceramic balls in which pores ranging in size from ones of nanometers to tens of micrometers are hierarchically interconnected to one another. This hierarchical porous structure ensures high specific surface areas and porosities for the porous ceramic balls. Further, the size and distribution of the pores can be simply controlled with hydrophobic solvent and reaction time. The pore formation through polymer self-assembly and sol-gel reactions can be applied to ceramic and transition metals. Porous structures based on bioceramic materials, such as bioactive glass, allow the formation of apatite therein and thus can be used as biomaterials of bioengineering, including bone fillers, bone reconstruction materials, bone scaffolds, etc.

Osteogenesis scaffold such as for spinal fusion or an intermedullary nail includes a number of arcuate struts. The scaffold may have a functional modulus of elasticity that is a result of the modulus of the material of the struts together with the architecture of the struts, and may be within the range of 5 GPa and 75 GPa. An anisotropy of a physical property such as stiffness, compressive strength or elastic modulus corresponds to the same physical property of native bone in the vicinity of the intended implantation site.

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.

The invention discloses a 3D-printed gradient-diameter medical porous metal bone tissue scaffold and aims to solve the problems that a single repeated microporous structure in the prior art is adverse to bone tissue ingrowth and a bone tissue implant has difficulty in bony healing with self-bones. The scaffold is in a hexahedron structure as a whole, and comprises components A, components B and components C in tight arrangement, wherein the components A are arrayed on an outermost layer of the hexahedron structure; the components B are arrayed on a secondary outer layer; and the components C are arrayed on the innermost layer; all the components A, B and C are in a hexahedron frame structure; the pore diameter of the components A is greater than that of the components B; and the pore diameter of the components B is greater than that of the components C. Through the reinforcing structural design, the gradient-pore tissue engineering bone scaffold is produced; through regulating the ingrowth of bone tissues, fibroblasts and the like by gradient-change pores, the optimal bone healing can be achieved finally.

The invention discloses a tissue engineering bone/cartilage double-layer scaffold and a construction method and application in medical science. The method adopts natural cartilage and bone as materials, respectively removes the antigenicity of the cartilage and the bone through de-cell, and adopts a freezing and drying method to prepare the double-layer scaffold simultaneously suitable for growthof the two issues of the bone and the cartilage. A preparation method comprises that: acellular bone is soaked in suspension of cartilage acellular matrix microfilaments, and the double-layer scaffoldof which the upper layer is a cartilage acellular matrix three-dimensional porous spongy scaffold and the lower layer is an acellular bone scaffold is prepared by the freezing and drying method and acrosslinking method. The cartilage acellular matrix spongy scaffold part of the double-layer scaffold can be introduced with factors promoting the formation of the cartilage, and the acellular bone part can be introduced with factors promoting the formation of the bone, and the factors can be respectively inoculated with cells for forming the cartilage or the bone to construct a living tissue engineering bone/cartilage complex, which is used for repairing bone and cartilage complex defect or total joint defect clinically.

The invention discloses a magnesium alloy/biological ceramic bone bracket based on photocuring and gel casting and a forming method of the bone bracket. The method comprises the following steps of: establishing computer-aided design (CAD) models of the bracket and a bracket negative model through shape correlation and microstructure simulation by using reverse engineering and CAD according to the structures of different bone defect parts and the analysis results of biomechanics; making a resin bracket negative model by a photocuring technology; filling ceramic slurry into the bracket negative model by a gel casting process, curing and sintering at a high temperature to make a biological activity ceramic framework with mutually-communicated porous pipelines; and casting molten magnesium alloy into the porous pipelines of the biological activity ceramic framework by a vacuum suction casting method, cooling for solidification, and thus obtaining the magnesium alloy/biological ceramic simulation composite structure bone bracket. The internal microstructure of the made bracket consists of the mutually-communicated pipelines, the magnesium alloy is filled in the pipelines to increase the early mechanical property of the composite bracket, and the pipelines filled with the magnesium alloy become mutually-communicated pore passages as the magnesium alloy is corroded and degraded, so that the requirements of organization growth, nutrition and metabolism are met.

The invention provides a fast and reliable artificial bone prosthesis manufacturing method which includes: using the CT or MRI scanning technology to obtain the image data of all bones of a human body under a healthy state, and a building a database of the image data; generating three-dimensional models of the bones by the bone image data in the database; performing optimization design and analysis, which includes constructions of bone cavities, bone scaffolds and bone micropore basal bodies and virtual simulation analysis such as statics analysis, kinematics analysis and kinetics analysis, on the three-dimensional models of the bones; using additive manufacturing to manufacture artificial bone prosthesis on the basis of the optimized three-dimensional models of the bones; performing bioactivity treatment on the manufactured artificial bone prosthesis; performing quality inspection on the artificial bone prosthesis after the bioactivity treatment. By the method, the artificial bone prosthesis high in reliability can be manufactured fast aiming at each patient, disability possibility of the patient is lowered, and material waste is avoided.

The invention discloses a three-dimensional silk fibroin scaffold insoluble in water, and preparation and application of the three-dimensional silk fibroin scaffold. A preparation method includes the steps of injecting silk fibroin solution with the mass concentration of 0.3-30% into a mold, and obtaining a three-dimensional silk fibroin scaffold after freeze-drying; performing humid and heat crosslinking for the mold under the condition that the temperature ranges from 50 DEG C to 100 DEG C and the relative humidity ranges from 70% to 100%; and drying, removing the mold and obtaining the three-dimensional silk fibroin scaffold insoluble in water. Silk fibroin is used as a raw material, and biocompatibility is good; a preparation process is non-toxic and environment-friendly, and shape, aperture and porosity parameters of the scaffold are easy to control; the pore wall of the scaffold is nano-scale, the aperture of the scaffold is micron-scale, an extracellular matrix micro-environment is simulated, and the three-dimensional silk fibroin scaffold is used as a three-dimensional cell culture vector or a three-dimensional plasmid transfection vector when used externally; and the three-dimensional silk fibroin scaffold is used in the aspects of cartilage scaffolds, fat scaffolds, bone scaffolds, muscle scaffolds and the like when used in the internal tissue engineering field.

The invention relates to a digital coralline hydroxyapatite artificial bone scaffold and a preparation method thereof. The preparation method is characterized by comprising the following steps: 1) mixing coralline hydroxyapatite artificial bone particles and poly-L-lactic acid into a base material based on the mass ratio of 3:1; and 2) carrying out thin-layer CT scanning on bone sections, forming the shape of the artificial bone scaffold by utilizing an automatic molding machine and then carrying out laser sintering on the mixed base material to obtain the digital coralline hydroxyapatite artificial bone scaffold. The invention overcomes the complicated technology for preparing micropores in a rapid forming process and the defects that the coralline hydroxyapatite artificial bone is difficult to be prepared into the bone scaffold in a specific shape according to the clinical need; and the prepared digital coralline hydroxyapatite artificial bone scaffold can fully remain the natural micropore structure and good biocompatibility of coralline hydroxyapatite (CHA), and can be prepared into various specific shapes according to the clinical need.

The invention relates to a ligament-bone composite scaffold with a biomimetic connecting interface and a forming method thereof. The forming method comprises the following steps: firstly simulating a natural ligament-bone interface structure and utilizing a rapid forming technology to manufacture a resin negative type of a bone scaffold model with a fiber connecting structure; pouring a bone scaffold material solution into the resin negative type, and performing freeze-drying and high-temperature sintering to manufacture a bone scaffold with an internal communication pipeline and the fiber connecting structure; then primarily connecting ligament fiber with the fiber connecting structure of the bone scaffold, and fixing a die used for manufacturing of a biomimetic interface with a ligament-bone scaffold formed by primary connection; pouring the ligament material composite solution with the bone scaffold material in various changes of concentration into the interface of the ligament and the bone scaffold as secondary connection; and performing freeze-drying and removing the die, so as to obtain the ligament-bone composite scaffold with the biomimetic interface. According to the invention, the transmission of nutrients and metabolites is facilitated, the connecting strength of the ligament-bone composite scaffold is improved, and the ingrowth of cells after implantation is facilitated.

The invention relates to a method for preparing a porous bone scaffold by laser and increasing mechanical and biological performances of the porous bone scaffold by adding zinc oxide with little amount, which belongs to the bone tissue engineering field. Aiming at uncontrollable performances of aperture distribution, shape, space direction and connectivity in the preparation method of a traditional bone scaffold, and aiming at the disadvantages of poor mechanical property and fast resolving rate existed in tricalcium phosphate (beta-TCP), the invention provides the method for preparing the porous bone scaffold by using a selective laser sintering (SLS) technology, and provides the method for increasing performance by adding zinc oxide (ZnO). The method for preparing the porous bone scaffold has the advantages that the porous scaffold which enables three-dimensional interconnection is prepared by SLS, zinc oxide with little amount is added for introducing into a liquid phase, the particles densification can be promoted, crystal grain is refined, and the mechanical performance is improved, simultaneously, cell compatibility is increased, the degradation rate is reduced, and the biological performance is increased, so that the interconnected porous beta-TCP bone scaffold with enhanced mechanical performance and good biological performance can be finally prepared. The method has the advantages of simple preparation technology, convenient operation, low cost, easy control of technical parameter and the like.

The invention belongs to the field of biology, and particularly relates to bone scaffold material, with a shape memory function, for jaw repair and a preparation method thereof. The bone scaffold material comprises the following raw materials in part by weight: 5 to 100 parts of polycaprolactone (PLC), 5 to 100 parts of poly butylenes succinate (PBS), 5 to 100 parts of poly (lactic-co-glycolic acid) (PLGA), and 5 to 100 parts of tertiary calcium phosphate (TCP). The bone scaffold material comprises the following raw materials in part by weight: 80 to 100 parts of polycaprolactone (PLC), 10 to 50 parts of poly butylenes succinate (PBS), 10 to 50 parts of poly (lactic-co-glycolic acid) (PLGA), and 30 to 60 parts of tertiary calcium phosphate (TCP). The method also provides a method for preparing the bone scaffold.

The invention will have a certain shape of vitreous immersed in the solution, adjusting the pH more than 7, stirring constantly, and depositing nanometer-scale hydroxyapatite on the glass surface. When dissolved all the glass, the glass in situ formed same size hydroxyapatite physical as the glass exterior. Soluble glass network is constituted oxide B2O3 or P2O5 or both, or part of both SiO2. Except CaO, glass networks gap oxides also contain one or more of the other monovalence, bivalence, tervalence, quadrivalence metal oxides, to regulate the speed of the solubility. The process is simple, easy to operate and low cost. Under the temperature of close proximity to human body, glass particles which contain calcium can combine with phosphorus in the body fluids to form inorganic mineral components, carbonic acid hydroxyapatite ceramic, which is closer to human bone tissue. Thus, this method has broad aspects of the application in the preparation of materials for hard tissue repair and bone in vitro tissue for culturing cells in bone scaffolds.

A tissue-engineered bionic bone scaffold with high biocompatibility, bioactivity, degradability and osteoplastic induction has a three-layer structure composed of external degradable compact biofilm layer, central porous layer with less pore diameter for high mechanical strength, and internal porous layer with big pore diameter for transferring nutrients. Said central and internal layers are a composition consisting of in-situ formed nano-phase Ca-P salt and degradable biologic material.

The invention relates to a bone scaffold forming system comprising an image scanning unit, a three-dimensional reconstruction unit, a three-dimensional model building unit, a bone scaffold model building unit, a hierarchical processing unit and a low-temperature forming unit. By the aid of the bone scaffold forming system, scanning imaging is performed on the bone injury part of a patient before bone scaffold forming by means of medical imaging technology so as to obtain image data of the bone injury part, then the acquired image data are subjected to modular processing to obtain hierarchical data of a to-be-repaired bone scaffold model, bone formation materials are utilized to prepare a bone scaffold exactly matched with the bone defect part of the patient in size and shape by the low-temperature forming unit through the hierarchical data, and accordingly the bone scaffold matched with the implanting part is prepared for the patient in vitro before surgery implementation to the benefit of shortening implementing time, further implant materials are enabled to be closely bonded with the defect part to promote bone formation.

The invention relates to a mineralized collagen bionic bone repair material modified by hyaluronan oligosaccharide and a preparation method of the mineralized collagen bionic bone repair material. The mineralized collagen bionic bone repair material modified by hyaluronan oligosaccharide has the following structure: collagen in a collagen-hydroxyapatite composite material is connected with hyaluronan oligosaccharide through C/N bonds, thus obtaining the mineralized collagen composite material with galactosylated modification, wherein the molecular weight of the hyaluronan oligosaccharide is 776-5000 Da. According to the mineralized collagen bionic bone repair material and the preparation method, Schiff base reaction is adopted for carrying out hyaluronan oligosaccharide modification on the collagen for the first time, the glycosylated collagen realizing covalent binding is obtained, meanwhile, the glycosylated collagen is taken as a mineralization template to be applied to the design of the bone scaffold for the first time, the functions facilitating cell migration, proliferation and differentiation and promoting wound healing of low-molecular-weight HA are exerted, and a novel material basis and research strategy are provided for the in-vitro construction of the vascularized stent.