Ligament-bone composite scaffold with biomimetic connecting interface and forming method thereof

Abstract

The invention relates to a ligament-bone composite scaffold with a biomimetic connecting interface and a forming method thereof. The forming method comprises the following steps: firstly simulating a natural ligament-bone interface structure and utilizing a rapid forming technology to manufacture a resin negative type of a bone scaffold model with a fiber connecting structure; pouring a bone scaffold material solution into the resin negative type, and performing freeze-drying and high-temperature sintering to manufacture a bone scaffold with an internal communication pipeline and the fiber connecting structure; then primarily connecting ligament fiber with the fiber connecting structure of the bone scaffold, and fixing a die used for manufacturing of a biomimetic interface with a ligament-bone scaffold formed by primary connection; pouring the ligament material composite solution with the bone scaffold material in various changes of concentration into the interface of the ligament and the bone scaffold as secondary connection; and performing freeze-drying and removing the die, so as to obtain the ligament-bone composite scaffold with the biomimetic interface. According to the invention, the transmission of nutrients and metabolites is facilitated, the connecting strength of the ligament-bone composite scaffold is improved, and the ingrowth of cells after implantation is facilitated.

Description

technical field [0001] The invention relates to the technical field of biomanufacturing of multi-material and multi-structure bracket composite forming, in particular to a ligament-bone composite bracket with a bionic connection interface and a forming method thereof. Background technique [0002] Ligaments are the key to maintaining the stability of human joints and normal movement ability, but sports or accidents often lead to non-healing damage or rupture of ligaments, and ligament reconstruction surgery is required clinically to restore their physiological functions. At present, the joint and ligament grafts used in ligament reconstruction surgery, such as autologous ligament, allogeneic ligament, non-degradable artificial ligament, etc., consider their characteristic requirements in terms of strength, while ignoring the interface connection relationship between natural ligament and bone tissue. , medical screws and other means of "mechanical fixation" with the autologou...

AI Technical Summary

Problems solved by technology

At present, the joint and ligament grafts used in ligament reconstruction surgery, such as autologous ligament, allogeneic ligament, non-degradable artificial ligament, etc., consider their characteristic requirements in terms of strength, while ignoring the interface connection relationship between natural ligament and bone tissue. , medical screws and other means of "mechanical fixation" with the autologous bone, it is difficult to form a firm tissue fusion between the graft and the autologous bone tissue, and the long-term clinical efficacy is poor: either because the fusion tunnel in the autologous bone is enlarged and pulled out, or because of the connection Stress concentration at the place and fatigue fracture

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