481 results about "Clinical efficacy" patented technology

The present disclosure provides methods to quantify and analyze various CSF Tau species and the use thereof to measure pathological features and / or clinical symptoms of tauopathies, including determining the amount of time to dementia due to Alzheimer's disease, determining the time from dementia onset, staging Alzheimer's disease, guiding treatment decisions, and evaluate the clinical efficacy of certain therapeutic interventions.

The invention discloses an ultra-high dose rate radiotherapy plan optimization system based on compensator modulation, and relates to the technical field of radiotherapy. A data acquisition module is used for acquiring medical image data of a patient and receiving a clinical target; the clinical target comprises a target region prescription dose, an organ-endangering limit and a minimum dose rate threshold value required for triggering and maintaining a FLASH effect; and the FLASH biological effect evaluation module is used for calculating FLASH biological effective dose distribution corresponding to the physical dose distribution through an embedded biological effect model based on the input physical dose distribution and dose rate distribution. According to the method, the physical dose is converted into the accurate FLASH biological effective dose through the improved linear quadratic model embedded with the FLASH correction factor, the target tumor killing effect is guaranteed, normal tissue protection is enhanced with the help of the tissue differentiation correction factor, the industrial pain point that the physical dose reaches the standard but the biological effect does not reach the expectation is effectively solved, and the application prospect is wide. And the treatment plan better meets the clinical curative effect and safety core requirements.

The invention discloses a multi-agent real-world clinical curative effect evaluation and accurate decision-making system, and relates to the technical field of medical data processing. According to the invention, a research demand analysis agent generates a research scheme after understanding the input content of a user and transmits the research scheme to a data management agent, a statistical analysis modeling agent, a result report generation agent, a data security agent and the data management agent privacy and encrypt data uploaded by the user; meanwhile, additional feature construction is carried out according to the research requirement of a user to form brand new analysis data used by a subsequent statistical analysis modeling agent, and after the statistical analysis modeling agent obtains the data, an analysis result is obtained by calling external software and is transmitted to a result report generation agent; and generating a clinical evaluation report together with the research scheme transmitted by the research demand analysis agent. According to the invention, full-process automatic, specialized and safe research support is realized.

Provided is a recombinant human serum albumin-collagen binding domain (CBD) fusion protein for tumor-specific targeting matrix and its use in specific targeted treatment of a solid tumor. HSA and the CBD generate gene fusion in the form of different molecular structures, and can be expressed in a constructed recombinant engineered host. A pharmaceutical recombinant fusion protein is obtained through large-scale fermentation. The recombinant fusion protein shows tumor-specific targeting of solid tumors and can be used as a starting material of a broad-spectrum matrix carrier. The recombinant fusion protein is coupled with any tumor treatment drug, small-molecule compound, or cytotoxic protein to form an innovative pharmaceutical composition. The pharmaceutical composition of the recombinant fusion protein is also long-acting, can prolong a half-life of the conjugate drug in vivo, and has a significantly better clinical curative efficacy on anti-tumor than that of a monomer drug.

The invention discloses a traditional Chinese medicine extract composition for treating diabetic complications and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine extract composition is mainly prepared from the following raw material extracts: raw radix astragali, rhizoma anemarrhenae, rhizoma atractylodis, cortex phellodendri, radix trichosanthis, fructus corni, radix puerariae and ginseng leaves. The traditional Chinese medicine composition is used for treating diabetes mellitus and various complications thereof, including diabetes mellitus complicated with coronary heart disease, diabetes mellitus complicated with hypertension, diabetes mellitus complicated with cerebrovascular lesion, diabetic nephropathy, diabetic fundus lesion, diabetic peripheral neuropathy and the like, and has the advantages of remarkable clinical curative effect, no obvious side effect, low price, good comprehensive therapeutic property and the like.

The invention discloses a preparation method of a coating loaded with an antibacterial coating. The preparation method comprises the following steps: pretreating a titanium sheet, preparing an electrolyte, preparing Ti (at) col-I, preparing Carat UiO-66, preparing a Ti (at) col-I (at) Carat UiO-66 coating, and preparing a Ti (at) col-I (at) Carat UiO-66 (at) LBL coating. According to the coating preparation method and the implant provided by the invention, the carvacrol-loaded UiO-66 mineralized collagen coating is prepared by utilizing an electrochemical deposition and layer-by-layer self-assembly technology, so that the surface osseointegration capability of a titanium-based material is improved, the surface of the titanium-based material is endowed with antibacterial capability, and infection around the implant is reduced; the initial stability and the clinical curative effect are improved.

The invention provides a construction method of a fingerprint spectrum of Xinbao pills. The construction method comprises the following steps: 1) preparing a test solution and a mixed reference solution; and 2) constructing the fingerprint spectrum of the Xinbao pill: respectively taking the test solution and the mixed reference substance solution, and performing high performance liquid chromatography detection to obtain the fingerprint spectrum of the Xinbao pill. The invention belongs to the technical field of traditional Chinese medicine preparation detection, and provides a construction method of a fingerprint spectrum of a Xinbao pill, the method is simple and easy to implement, has the advantages of good precision, stability and repeatability and the like, can realize detection of multiple components of the Xinbao pill, and well reflects the overall quality condition of the Xinbao pill; meanwhile, the established HPLC fingerprint spectrum of the Xinbao pill is rich in detection components, totally 21 common characteristic peaks are determined and cover anti-heart-failure active components in ginseng, pseudo-ginseng, venenum bufonis and flos daturae medicinal materials in the Xinbao pill, reference can be provided for comprehensively controlling the internal quality of the Xinbao pill, and the clinical curative effect of the product is further ensured.

The invention provides application of active decapeptide in preparation of a medicine for preventing or treating cerebral apoplexy, and belongs to the technical field of biological medicine, the active decapeptide with the amino acid sequence as shown in SEQ ID NO.1 is applied to prevention or treatment of cerebral apoplexy for the first time, the active decapeptide can effectively inhibit formation of cerebral thrombosis of zebra fish with ischemic cerebral apoplexy, and the active decapeptide can be used for preventing or treating cerebral apoplexy. The brain blood flow supply is recovered; meanwhile, the active decapeptide can significantly reduce the hemorrhagic area and hemorrhagic rate of the zebra fish brain with hemorrhagic stroke, repair brain vascular injury and inhibit the occurrence and development of hemorrhagic stroke. In addition, the active decapeptide has small toxic and side effects, and is of great significance for improving the clinical curative effect of cerebral apoplexy and reducing the medication risk when being used for research and development of novel drugs for resisting cerebral apoplexy.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound composition with a treatment effect on rapid atrial fibrillation and a preparation method of the traditional Chinese medicine compound composition. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma polygonati, radix rehmanniae preparata, radix paeoniae alba, spina date seed, mulberry, jujube kernel, schisandra chinensis, Huai wheat, radix ophiopogonis, ligusticum wallichii, salvia miltiorrhiza, radix rehmanniae, coptis chinensis, radix paeoniae rubra, liquorice, fingered citron, calcined dragon bone, calcined oyster shell and rose. The invention aims at the basic pathogenesis of rapid atrial fibrillation dialectically belonging to insufficiency of heart yin, deficiency of essence and blood, unsmooth emotion, blood vessel stasis, stasis depression and fever which are caused by tachycardia and irregular pulse and rhythm. The clinical research proves that the traditional Chinese medicine compound composition can obviously reduce the recurrence frequency and recurrence rate of patients suffering from paroxysmal rapid atrial fibrillation and improve the symptoms of palpitation, chest distress, palpitation and the like of rapid atrial fibrillation, and has the advantages of good clinical curative effect and wide application prospect. The defects of western medicines can be well overcome.

The invention relates to the technical field of medicines, and provides a guaiol pentopromethazine controlled release tablet and a preparation method thereof. The guaiol pentopromethazine controlled release tablet comprises a tablet core and a coating for coating the tablet core, the tablet core comprises the following raw material components: a first active pharmaceutical ingredient, a skeleton carrier, an osmotic pressure accelerant and a disintegrating agent; the coating comprises the following raw material components: a film-forming material and a second active pharmaceutical ingredient; the first medicine active component and the second medicine active component both comprise potassium guaiacol sulfonate, pentoxyverine citrate and promethazine hydrochloride. The invention has the beneficial effects that the controlled release tablet provided by the invention can realize relative stability of blood concentration, so as to solve the problems of'crest 'and'trough' phenomena of blood concentration caused by single administration in the clinical use process and short drug release action time, improve the clinical curative effect and reduce the cost. The adverse reaction caused by overhigh peak stage of the blood concentration is reduced, and the drug resistance phenomenon is reduced.

The invention discloses a quick-acting dysmenorrhea patch. The quick-acting dysmenorrhea patch comprises a medicine physical therapy layer which is prepared from the following raw materials in parts by weight, comprising 12 to 16 parts of borneol, 4 to 6 parts of musk, 12 to 18 parts of a saffron crocus extract concentrated solution, 9.5 to 14.5 parts of a white peony root extract concentrated solution, 9.5 to 14.5 parts of Chinese angelica, 10.5 to 15.5 parts of a frankincense extract, 10.5 to 15.5 parts of a myrrh extract, 3.5 to 5 parts of a motherwort herb extract concentrated solution, 6 to 9 parts of a ligusticum wallichii extract concentrated solution, 4 to 11 parts of a wormwood extract concentrated solution, 1.5 to 3 parts of nano magnetic powder and 6 to 12 parts of a far infrared material. The dysmenorrhea patch provided by the invention achieves a remarkable clinical curative effect by virtue of scientific proportioning of various traditional Chinese medicine components, a modern extraction technology and combination with a physical therapy, and has the characteristics of quick response, safety and convenience in use.

The present invention relates to the field of biomedicine. Provided are an anti-human IL-4Rα antibody or an antigen-binding fragment thereof and the use thereof. The anti-human IL-4Rα antibody comprises heavy chain complementarity determination regions HCDR1, HCDR2 and HCDR3, and light chain complementarity determination regions LCDR1, LCDR2 and LCDR3, has high affinity with human IL-4Rα, can be used for preparing an antibody drug, can be used for treating type-II inflammatory diseases, and has relatively good clinical efficacy and relatively low toxic and side effects. Further provided are a bispecific antibody against both IL-4Rα and TSLP, and the use of the antibody in the preparation of a drug for treating severe asthma, moderate to severe atopic dermatitis and chronic obstructive pulmonary disease.

The invention provides a method and device for predicting the treatment effect of methotrexate on psoriasis. According to the method for predicting the therapeutic effect of MTX on psoriasis, the PRS is calculated according to related information of 33 SNP loci in a blood sample of a psoriasis patient, the clinical therapeutic effect of MTX on psoriasis can be well predicted according to the calculation result of the PRS, and clinical doctors can be guided to detect and analyze MTX therapy adopted by part of patients in Chinese population; according to the present invention, the basis is provided for the improvement of the clinical treatment effect of the MTX, the important guiding significance is provided for the subsequent clinical treatment of the psoriasis patient, the improvement of the drug treatment efficiency of the psoriasis patient is easily achieved, and the prediction result of the treatment effect of the MTX on the psoriasis is accurate by simultaneously incorporating the related information of the 33 SNP loci so as to provide the basis for the clinical treatment effect of the MTX; and clinical doctors can be guided to formulate suitable MTX treatment intervention schemes according to individual differences of different patients.

The invention provides a traditional Chinese medicine composition for treating urolithiasis. Specifically, the invention provides a traditional Chinese medicine composition consisting of glechoma longituba, semen plantaginis, pyrrosia lingua, radix achyranthis bidentatae, radix paeoniae alba, radix puerariae and honey-fried licorice root. The traditional Chinese medicine composition is simple in formula and exact in clinical curative effect. The composition is used for treating urolithiasis, can effectively relieve kidney crystallization and renal tubule injury and improve the renal function, and has the application prospect in the field of urolithiasis treatment.

The invention relates to the field of biomedicine, and discloses a method for screening KRAS mutant interacting proteins, an HEK293T cell line for continuously expressing an HA-Turbo ID-KRAS variant is established by utilizing lentivirus transduction, the stability of transgene expression is ensured through puromycin screening, and variation caused by transient transfection is reduced as much as possible. After a Turbo ID mediated proximity marker is activated by biotin treatment, KRAS proximity binding proteins are covalently biotinylated, captured by NeutrAvidin bead purification, and analyzed by quantitative mass spectrometry. According to the invention, two potential KRAS mutation treatment target proteins of LZTR1 and LAMTOR1 can simultaneously inhibit activation and efficacy exertion of three different mutants of G12C, G12D and G12V of the G12 mutant, compared with drugs on the market that a single target of G12C directly targets the KRAS mutant, a brand new KRAS mutation targeting intervention strategy is provided, the clinical curative effect can be further improved, and the occurrence rate of secondary drug resistance can be effectively reduced.

The invention discloses a traditional Chinese medicine composition for treating fatty liver diseases related to metabolic dysfunction. The traditional Chinese medicine composition is prepared from the following raw material medicines: Qu fructus aurantii, lotus leaves, semen cassiae, gynostemma pentaphylla, rhizoma alismatis, rhodiola rosea, radix salviae miltiorrhizae, pseudo-ginseng and rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition and the traditional Chinese medicine compound preparation disclosed by the invention can improve the blood sugar and blood fat levels of fatty liver diseases related to metabolic dysfunction and improve the metabolic level, are remarkable in clinical curative effect, improve the living quality of patients, have the effects of regulating qi, soothing the liver, tonifying the spleen and removing stasis, slow down liver fibrosis by improving blood sugar and blood fat metabolism, and are quick in curative effect and low in price.

The invention discloses a traditional Chinese medicine property definition system and method for a chemical medicine, and relates to the technical field of medicine classification, and the technical key points are that the system comprises the following modules: a traceability module which traces a related herbal medicine source when the chemical medicine is initially born; the medicine property judgment module 1 judges the medicine property of the chemical medicine according to the medicine property of the herbal medicine source; the medicine property judgment module 2 is used for judging the medicine property of the chemical medicine according to the medicine effect, the side effect, the indications and the contraindications of the chemical medicine; the comprehensive judgment module is used for determining five-element attributes and dominant medicine flavors of the chemical medicines under a decoction meridian diagram framework according to the medicine property judgment module 1 and the medicine property judgment module 2; and the toxicity judgment module is used for determining whether the medicine has toxicity or not according to the sexual effect characteristics, the adverse reaction risk, the pharmaceutical monitoring content and the real-world phytotoxicity risk of the medicine. The traditional Chinese medicine property of the chemical medicine is defined from the two dimensions of a herbal medicine base source and sexual efficacy toxicology, and the basis is more sufficient and can be better combined with the clinical efficacy.

The invention relates to an application of an ezetimibe derivative in preparation of an anti-prostatic cancer drug, and belongs to the technical field of medicinal chemistry. The general formula structure of the ezetimibe derivative L14 is # imgabs0. The ezetimibe derivative L14 can be used for preparing new drugs for treating CRPC and NEPC without depending on an androgen receptor pathway, the clinical curative effect is improved, and the clinical drug selection is increased. The micromolecule L14-8 (R1 = R2 =-C (O) CH = CH2) can specifically inhibit proliferation of prostate cancer cells in vitro and can also inhibit growth of prostate tumors in vivo; in the aspect of drug combination, the AR antagonist and the low-dose small molecule L14-8 are combined for use, so that the sensitivity of CRPC and NEPC to the AR antagonist can be remarkably improved, the drug resistance induced by the AR antagonist can be possibly inhibited, and the clinical benefits of the AR antagonist can be improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of Xianglian intestine decoction in preparation of a medicine for treating ulcerative colitis through a targeted TLR4 / NLRP3 / GSDMD channel. According to the invention, the TLR4 is determined as a key target, and experiments show that the active ingredients in the Xianglian intestine soup and the TLR4 have very strong binding affinity. In-vivo experiments prove that the Xianglian intestine soup down regulates the protein levels of TLR4, NLRP3 and GSDMD-N and the mRNA expression (Plt; 0.05) of IL-1beta and IL-18, so that the pyroptosis is inhibited. Furthermore, the Xianglian intestine decoction inhibits NLRP3 inflammasome activation and GSDMD-mediated pyroptosis by targeting TLR4 so as to relieve UC inflammation and intestinal barrier injury. The invention provides a mechanism insight for the clinical curative effect of the Xianglian intestine decoction for treating ulcerative colitis.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The invention provides a pulmonary nodule patient treatment prediction method based on artificial intelligence, and the method comprises the steps: obtaining a historical tongue picture feature and a historical pulmonary nodule CT image, extracting a tongue coating color value RGB component, a spatial frequency of a tongue surface texture feature, a gradient value of pulmonary nodule edge sharpness, and a CT value standard deviation of pulmonary nodule density distribution, and obtaining an initial feature set; extracting the change trend of the tongue coating thickness and the pulmonary nodule edge sharpness in the treatment cycle from the weighted feature set, analyzing the dynamic evolution rule of the correlation between the change rate of the tongue coating thickness and the gradient value of the pulmonary nodule edge sharpness, and obtaining a time sequence feature vector in combination with the time rhythm characteristics of the traditional Chinese medicine tongue diagnosis; and carrying out standardization and normalization processing on the fusion feature set, predicting by combining a clinical curative effect evaluation standard and a pulmonary nodule iconography improvement index to obtain the correlation strength of the change rate of the thickness of the tongue coating and the improvement trend of the edge sharpness of the pulmonary nodule in a treatment cycle, and obtaining a predicted curative effect result.

The invention belongs to the technical field of medical monitoring, and provides an inhalation treatment monitoring method and system based on the Internet of Things, and the method comprises the steps: collecting the inhalation flow value and the breath-holding time length of a single treatment behavior of a patient through an intelligent flow speed monitoring device in a jet atomizer, generating an inhalation and breath-holding time sequence, and carrying out the collection of the inhalation flow value and the breath-holding time length; calculating a pseudo-compliance evaluation value to judge whether pseudo-compliance exists or not, if so, analyzing the relevance between the pseudo-compliance evaluation value and the pseudo-compliance evaluation value through a distance correlation coefficient, during relevance, constructing an influence capture model by using an attention mechanism-residual network model, outputting an influence coefficient, and performing positive and negative coordination analysis; according to the method, the mist amount and the flow speed are adjusted based on the standard range and the influence coefficient, accurate evaluation of false compliance is achieved, effectiveness and controllability of inhalation treatment are improved through correlation analysis and parameter linkage optimization, the method is suitable for inhalation treatment equipment such as a jet atomizer, and improvement of treatment compliance and clinical curative effect of a patient is facilitated.

The invention discloses a radix astragali, rhizoma polygonati and ligustrum lucidum ait traditional Chinese medicine preparation for treating myelosuppression as well as a preparation method and a detection method thereof. The preparation is prepared from 50-150 parts of radix astragali, 50-150 parts of wine-processed rhizoma polygonati, 25-75 parts of wine-processed ligustrum lucidum ait, 50-150 parts of blanched rhizoma drynariae, 50-150 parts of radix trichosanthis and 25-75 parts of herba epimedii. The optimal extraction process and refining process are screened out based on effective components and pharmacological activity through a large number of tests, and the optimal preparation process of the Shuanghuangliangwhitening oral liquid and other traditional Chinese medicine preparations is obtained through stability investigation and verification. According to the invention, a thin layer chromatography is adopted, the four medicinal materials of astragalus membranaceus, glossy privet fruit, rhizoma drynariae and herba epimedii are respectively subjected to thin layer chromatography research, and methodology research shows that the method is stable and feasible. The invention establishes a content determination method for astragaloside, calycosin-7-glucoside, specnuezhenide and icariin, establishes a quality standard, and has important significance for ensuring the clinical curative effect and safety of astragaloside, calycosin-7-glucoside, specnuezhenide and icariin.

The invention discloses a rehabilitation equipment fault data monitoring method and system, and particularly relates to the technical field of electric digital data processing, comprising the following steps: S1, synchronously acquiring equipment operation time sequence data and patient interaction time sequence data, S2, performing feature extraction and adaptive fusion on the two types of data, and S3, acquiring the data of the equipment operation time sequence and the patient interaction time sequence; s3, equipment health prediction and rehabilitation curative effect deviation prediction are executed in parallel based on the fusion features, and the relevance of the equipment health prediction and the rehabilitation curative effect deviation prediction is analyzed through a cross attention mechanism, and S4, a personalized dynamic baseline model is combined, and an equipment fault risk value, a curative effect deviation degree and a relevance confidence degree are integrated to generate hierarchical monitoring feedback. According to the invention, by constructing an equipment-patient-curative effect ternary closed-loop analysis framework, the spanning from pure fault early warning to treatment effectiveness guarantee is realized, the problems of single monitoring dimension and unhooking with clinical curative effect in the prior art are solved, and the method has the outstanding effects of strong early warning perspectiveness, low false alarm rate and support of root cause analysis.

The invention provides a traditional Chinese medicine preparation quality detection method and system based on multi-dimensional data analysis, and belongs to the technical field of traditional Chinese medicine preparation quality detection. The method comprises the following steps: acquiring mass spectrum data and nuclear magnetic resonance data of various active components in a preparation to generate a multi-dimensional chemical characteristic data set; synchronously collecting corresponding data of the medicinal raw materials, and constructing a process and environment association database; constructing a chemical and process coupling analysis model; and monitoring the production process in real time to obtain the dynamic chemical fingerprint spectrum. By constructing a full-component chemical map and associating the full-component chemical map with process and environmental parameters and combining clinical curative effect data to establish a drug effect and component response curved surface model, the limitation that only a few index components are concerned in traditional detection is broken through, so that a detection result can accurately reflect the multi-target and overall regulation characteristics of the traditional Chinese medicine preparation, and the detection accuracy is improved. The problem that the components are qualified but the curative effect is poor due to single detection dimension is avoided, and the relevance between quality detection and the clinical curative effect is remarkably improved.

The invention discloses an HPLC (High Performance Liquid Chromatography) specific chromatogram of Xiaoyin capsules / granules as well as construction and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and chlorogenic acid, gallic acid, hydroxysafflor yellow A, albiflorin, rutin, isovitexin, 5-O-methylvisamidoside, 3, 5-di-O-caffeoylquinic acid, 4, 5-di-O-caffeoylquinic acid, benzoic acid, quercetin, paeonol, kushenone and obakunone are taken as reference substances; the characteristic chromatogram is successfully constructed for detecting different batches of Xiaoyin capsules / particles. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least 14 components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be accurately, rapidly and simultaneously performed on a plurality of characteristic components of the Xiaoyin capsules / particles, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the Xiaoyin capsules / particles.

Antibodies for determining the level of FOXC1 protein in a subject's tumor and methods of using FOXC1 antibodies to predict clinical efficacy of a cancer therapeutic, predict prognosis of a subject receiving the cancer therapeutic, and treat the subject based on the predictions of clinical efficacy and prognosis.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate. Further, additional improvements in nerve localization and targeting may reduce the number of needle insertions, applied treatment cycles, and may also reduce the number of cartridge changes.

The invention provides a quality detection method of antiviral particles. The quality detection method adopts HPLC-MS / MS (High Performance Liquid Chromatography-Mass Spectrometry / Mass Spectrometry) to simultaneously determine the following components: forsythiaside A, patchouli ketone, verbascoside, mangiferin, 5-methoxy-8-hydroxypsoralen, curcumenol, luteolin-7-glucuronide, kaempferol-3-O-rutinoside, baicalin, rutin and bergamot phenol. The detection method is a quantitative determination method for 11 active components in the antiviral particles, the detection method is short in time and low in cost, the quantitative analysis method is expected to provide reference for quality control of the antiviral particles, and the clinical curative effect and safety of the antiviral particles are guaranteed.

The present invention relates to a Chinese medicine for treating late respiratory viral infection, wherein the Chinese medicine comprises the following raw materials in weight proportions: 280-350 parts of Pseudostellariae Radix, 100-140 parts of Cinnamon Twig, 130-170 parts of White Peony Root, 130-170 parts of Poria, 130-170 parts of Atractylodes Macrocephala, 280-340 parts of Shenqu, 100-140 parts of Morus Album, 100-140 parts of Trichosanthes, 130-170 parts of Houttuynia Cordata, 100-140 parts of Platycodon, 100-140 parts of Fritillariae Thunbergii, and 50-70 parts of Licorice. The prescription has the functions of invigorating Qi and nourishing Yin, clearing away heat and resolving phlegm. It is mainly used for treating the late stage of new coronavirus infection, influenza, common cold, etc., which are caused by disharmony between Ying and Wei, consumption of Qi and injury to Yin, physical weakness, fatigue, spontaneous sweating, fear of wind, cough and sputum, dry throat and sore throat, loss of appetite, pale red tongue, thin white or yellow fur, and floating and weak pulse. The traditional Chinese medicine is easy to take, has significant clinical efficacy, and a simple preparation process, and has a good market application prospect.