155 results about "Clinical efficacy" patented technology

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The invention discloses a rehabilitation equipment fault data monitoring method and system, and particularly relates to the technical field of electric digital data processing, comprising the following steps: S1, synchronously acquiring equipment operation time sequence data and patient interaction time sequence data, S2, performing feature extraction and adaptive fusion on the two types of data, and S3, acquiring the data of the equipment operation time sequence and the patient interaction time sequence; s3, equipment health prediction and rehabilitation curative effect deviation prediction are executed in parallel based on the fusion features, and the relevance of the equipment health prediction and the rehabilitation curative effect deviation prediction is analyzed through a cross attention mechanism, and S4, a personalized dynamic baseline model is combined, and an equipment fault risk value, a curative effect deviation degree and a relevance confidence degree are integrated to generate hierarchical monitoring feedback. According to the invention, by constructing an equipment-patient-curative effect ternary closed-loop analysis framework, the spanning from pure fault early warning to treatment effectiveness guarantee is realized, the problems of single monitoring dimension and unhooking with clinical curative effect in the prior art are solved, and the method has the outstanding effects of strong early warning perspectiveness, low false alarm rate and support of root cause analysis.

The invention provides a traditional Chinese medicine preparation quality detection method and system based on multi-dimensional data analysis, and belongs to the technical field of traditional Chinese medicine preparation quality detection. The method comprises the following steps: acquiring mass spectrum data and nuclear magnetic resonance data of various active components in a preparation to generate a multi-dimensional chemical characteristic data set; synchronously collecting corresponding data of the medicinal raw materials, and constructing a process and environment association database; constructing a chemical and process coupling analysis model; and monitoring the production process in real time to obtain the dynamic chemical fingerprint spectrum. By constructing a full-component chemical map and associating the full-component chemical map with process and environmental parameters and combining clinical curative effect data to establish a drug effect and component response curved surface model, the limitation that only a few index components are concerned in traditional detection is broken through, so that a detection result can accurately reflect the multi-target and overall regulation characteristics of the traditional Chinese medicine preparation, and the detection accuracy is improved. The problem that the components are qualified but the curative effect is poor due to single detection dimension is avoided, and the relevance between quality detection and the clinical curative effect is remarkably improved.

This invention discloses a composite nanozyme that enhances the clinical efficacy of oxaliplatin, its preparation method, and its application. The composite nanozyme consists of indium ruthenium nanozyme and an iliximab embedding and anchoring layer. The indium ruthenium nanozyme consists of indium ruthenium nanoparticles and a carbon-nitrogen framework, with the indium ruthenium nanoparticles loaded on the surface and within the pores of the carbon-nitrogen framework. The iliximab embedding and anchoring layer consists of a dithiol polyethylene glycol coating layer and iliximab. Preparation method: ZIF-8 is prepared by co-precipitation of zinc salt methanol solution and 2-methylimidazole methanol solution, followed by calcination to obtain the carbon-nitrogen framework. The carbon-nitrogen framework dispersion is then stirred in an oil bath with indium nitrate solution and ruthenium trichloride solution to prepare a nanozyme precursor, followed by calcination to obtain indium ruthenium nanozyme. The indium ruthenium nanozyme is dispersed in a dithiol polyethylene glycol solution, and iliximab solution is added dropwise. The resulting solid product is then dried. This invention can solve problems such as strong drug tolerance, insufficient intracellular accumulation, and severe tumor immunosuppression in oxaliplatin treatment.

The invention relates to the technical field of biomedical information, in particular to an umbilical cord mesenchymal stem cell donor matching database construction method based on HLA (human leukocyte antigen) typing, which comprises the following steps of: recording and storing data of a donor in a database to finish initial construction of the database; regularly rechecking the donor data record stored in the database, and updating the state identifier of the donor data record when the rechecked data is changed by a preset degree; and receiving a matching request containing the human leukocyte antigen typing data of the target patient and the target disease type, performing donor screening in the database by using a preset comprehensive matching degree model based on the matching request, and optimizing parameters of the comprehensive matching degree model through a machine learning model based on the matching record and the clinical curative effect data corresponding to the matching record. According to the method, the accuracy and effectiveness of umbilical cord mesenchymal stem cell treatment are improved, and meanwhile, the system has continuous self-evolution ability.

The application belongs to the field of medicine, and particularly relates to application of a Danzhu Fuguan formula in preparation of a drug for treating idiopathic membranous nephropathy (IMN). The Danzhu Fuguan formula comprises the following raw materials in parts by weight: 25-35 parts of Danshen, 10-15 parts of Baizhu, 25-35 parts of Huangqi, 10-20 parts of Jinyinhua, 10-20 parts of Hujiang, 10-20 parts of Yujin, 10-15 parts of Fuling, 25-35 parts of Yiyiren and 10-15 parts of Qianghuo. Research shows that the Danzhu Fuguan formula can effectively reduce the 24-hour urine protein level of IMN patients, and the 24-hour urine protein level shows a significant downward trend with the extension of the treatment course; according to the IMN clinical efficacy standard, the total remission rate of patients receiving the Danzhu Fuguan formula treatment for 3 months is 37%, the total remission rate of patients receiving the treatment for 6 months is 50%, and the total remission rate of patients receiving the treatment for 12 months reaches 72%, and the remission rate increases significantly with the extension of the treatment course.

The invention relates to a traditional Chinese medicine composition for treating or / and preventing hypoovarian reserve function as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of mulberries, 0.8-1.2 parts of Chinese wolfberry fruits, 0.8-1.2 parts of lily bulbs and 1.2-1.8 parts of Chinese yams stir-fried with bran. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition mainly tonifies kidney and replenishes essence, nourishes blood and yin, gives consideration to lung, spleen and liver, clears away heart fire and tranquillizes the mind, is homologous in medicine and food, few in medicine flavor and good in medicine effect, and is especially short in treatment course when being taken during ovulation promotion. Clinical curative effect observation and animal experiments both prove that under the specific dosage ratio, the synergistic interaction effect can be achieved.

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

The application discloses a method for simultaneously determining phenolic acid and tanshinone components in Danshen injection, and according to the structure and property characteristics of the phenolic acid and tanshinone components, the best mobile phase composition, elution program, flow rate, chromatographic column and mass spectrometry condition are screened through a large number of experiments. Experimental verification shows that the UPLC-TQ-MS / MS method can simultaneously determine 11 different structure and type of phenolic acid and tanshinone component compounds, and the methodological verification shows that the detection method has good precision, repeatability and high accuracy, and has important significance for controlling the quality of Danshen injection and guaranteeing the clinical curative effect.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating lower limb arteriosclerosis obliterans, which is technically characterized by being prepared from ten medicinal materials, namely red ginseng, astragalus membranaceus, cassia twig, morinda officinalis, cistanche deserticola, salvia miltiorrhiza, pseudo-ginseng, radix cyathulae, sargentgloryvine stem and semen brassicae according to a specific weight part ratio. Aiming at the core pathogenesis of yang deficiency and blood stasis of lower limb arteriosclerosis obliterans, the composition disclosed by the invention provides a treatment method of tonifying qi, warming yang, promoting blood circulation to remove blood stasis, removing speckles and dredging vessels, the compatibility of the whole formula is rigorous, and monarch, minister, assistant and guide are clear; moreover, the composition can be prepared into capsules or granules, is used for treating yang deficiency and blood stasis type lower limb arteriosclerosis obliterans, has an exact clinical curative effect, can remarkably improve symptoms of patients and lower limb blood flow, and is good in safety.

The invention discloses a method for establishing a fingerprint spectrum of a diaphoresis and antipyretic preparation, which comprises the following steps: preparing a test solution, and carrying out high performance liquid chromatography detection on the test solution, the test solution is prepared by the following steps: adding 65-75% of methanol or ethanol into a diaphoresis and anti-pestilence preparation, and carrying out ultrasonic treatment; the high performance liquid chromatography detection adopts gradient elution, and the gradient elution procedure is as follows: 0-15 min, 6-12% A; 12% A is changed into 20% A, and 20%-22% A is changed into 20% A after 15 min to 45 min and 45 min to 65 min; when the time is 65-85 minutes, 22% A is changed into 70% A; the fingerprint spectrum of the diuresis and antipyretic granules established by the invention can be used for objectively, comprehensively and accurately evaluating the quality of the diuresis and antipyretic granules, and has important significance for controlling the quality of diuresis and antipyretic granules and ensuring the clinical curative effect.

The application discloses a composition and a preparation method of a ripretinib cream, and the composition comprises: an active ingredient of ripretinib or a pharmaceutically acceptable salt thereof and excipients, wherein the excipients are composed of an oily base, a humectant, an emulsifier, water, a thickening agent, a preservative and a chelating agent, etc. The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM . The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM .

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a milrinone-citric acid monohydrate co-crystal. The application provides a new milrinone-citric acid monohydrate co-crystal and a preparation method thereof. The co-crystal has excellent properties, can significantly enhance the solubility and stability of milrinone, is helpful to improve the oral bioavailability, improve the clinical curative effect, has strong drug-making value, the preparation method is simple in operation and easy to control, and is suitable for industrial amplification.

This invention relates to a method for preparing genetically modified cells. Specifically, this invention provides a method for preparing genetically modified immune cells. This cell preparation method can rapidly prepare immune cells of high quality, thereby ensuring clinical efficacy.

The application discloses a kind of rehabilitation equipment failure data monitoring method and system, specifically related to electric digital data processing technical field, including S1, synchronous acquisition equipment operation time series data and patient interaction time series data, S2, two kinds of data are extracted and adaptively fused with features, S3, based on fusion features parallel execution equipment health prediction and rehabilitation curative effect deviation prediction, and the relevance of both is analyzed through cross attention mechanism, S4, combined with individualized dynamic baseline model, comprehensive equipment failure risk value, curative effect deviation and correlation confidence degree generate graded monitoring feedback.The application realizes the leap from simple failure early warning to treatment effectiveness guarantee by constructing equipment-patient-therapy ternary closed-loop analysis framework, solves the problem that the monitoring dimension of prior art is single and decoupled from clinical efficacy, and has the outstanding effect of strong early warning foresight, low false alarm rate and supporting root cause analysis.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating hyperuricemia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following main active ingredients in parts by mass: 15-25 parts of fried coix seeds, 15-25 parts of rhizoma smilacis glabrae, 15-25 parts of rhizoma alismatis, 5-15 parts of rhizoma atractylodis, 10-15 parts of semen plantaginis, 10-20 parts of yam rhizome, 10-20 parts of dogwood, 10-20 parts of Chinese yam, 10-20 parts of prepared rehmannia roots, 6-12 parts of prepared radix aconiti lateralis praeparata, 10-15 parts of cassia twigs and 6-12 parts of honey-fried licorice roots. The curative effect and safety evaluation research shows that the uric acid reducing effect of the traditional Chinese medicine composition after 12 weeks of treatment is equivalent to that of febuxostat, compared with febuxostat, the traditional Chinese medicine composition can remarkably reduce the occurrence rate of melt crystal pain of a patient during treatment, the liver and kidney functions of the treated patient are not obviously changed, and the safety is good. Research results show that the traditional Chinese medicine composition is remarkable in clinical curative effect and good in safety.

The traditional Chinese medicine comprises (1) radix puerariae, (2) radix angelicae sinensis, (3) radix salviae miltiorrhizae, (4) radix codonopsis, (5) radix astragali, (6) fructus perillae, (7) fructus ziziphi jujubae, (8) radix bupleuri, (9) radix scutellariae, (10) flos carthami, (11) radix curcumae, (12) radix et rhizoma rhei, (13) pericarpium zanthoxyli, (14) radix glycyrrhizae, (15) radix ophiopogonis, (16) fructus schizandrae, (17) radix aconiti carmichaeli, (18) radix ginseng, (19) poria cocos, (20) gypsum, (21) oyster, (22) cassia twig and (23) semen plantaginis. Or extracts of the above components, the amount of the extracts being equivalent to the amount of the raw materials of the corresponding components. The invention aims at the clinical curative effect of amyotrophic lateral sclerosis diseases with different pathological manifestations. The medicine can be combined with western medicines for use.

The invention discloses a new application of Renqingchangjue and an extract of Renqingchangjue. Specifically, the invention provides a new application of Tibetan medicine Renqingchangjue and an extract in preparation of a medicine for treating chronic atrophic gastritis, and systematically clarifies an exact molecular mechanism of the Tibetan medicine Renqingchangjue for treating CAG. The core of the invention is to reveal the core signal axis of Renqingchangjue by inhibiting TNF / NF-kB / Caspase-3 for the first time, so that the Renqingchangjue synergistically exerts the effects of resisting inflammation, resisting apoptosis and promoting mucosa repair, and provides a new intervention target and scientific basis for reversing gastric mucosa gland atrophy. The invention not only provides a modern pharmacological basis for the clinical curative effect of the Renqingchangjue, but also provides a brand new technical scheme and a protection basis for developing a medicine or a medicine composition which is based on the clear pathway target and is used for treating the chronic atrophic gastritis.

The invention belongs to the technical field of medicinal material quality control, and discloses a honeysuckle flower QAMS (quantitative analysis of multi-components by single marker) quality control method, which comprises the following steps: preparing a single reference solution and a mixed reference solution of chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, isochlorogenic acid A and isochlorogenic acid C, and preparing a test solution; after high performance liquid chromatography detection, the relative correction factors of other components in the honeysuckle are calculated by taking chlorogenic acid as an internal reference substance through chromatographic peak positioning, and the contents of the components in the honeysuckle are obtained by utilizing the relative correction components, so that the synchronous determination of the multiple components in the honeysuckle is realized. The method has the advantages of cost saving, simplicity in operation, high detection accuracy and good stability, has great significance in quality control and clinical curative effect guarantee of the honeysuckle medicinal material, and provides a basis for establishing a quality evaluation standard of the honeysuckle medicinal material.

The utility model discloses a customized artificial lunar bone prosthesis which comprises a lunar bone body, a joint cotyle is arranged in the middle of the lunar bone body, a head-moon joint protrusion capable of simulating the form and the movement track of a head-moon bone is installed in the joint cotyle, and the top of the head-moon joint protrusion is fixedly connected with a center nail. The free end of the center nail extends out of the lunar bone body and is arranged in a head-shaped bone of the wrist of the human body, and a plurality of sets of ligament suture holes are further formed in the back side of the lunar bone body. The customized artificial lunar bone prosthesis provided by the utility model aims to be applied to lunar bone replacement surgery, mainly aims to treat advanced lunar bone ischemic necrosis caused by non-traumatic or traumatic factors, and is beneficial to improving the stability of the prosthesis and improving the joint movement; basic biomechanics and clinical experiment research verify that the prosthesis has good mechanical properties and clinical curative effects, promote development of the lunar bone prosthesis, enable more patients to retain wrist joint movement, create more values for society and families, and contribute to achieving the goal of healthy China.

The invention discloses a traditional Chinese medicine composition for treating rheumatic bone pain and a preparation method of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The ointment consists of traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components of the ointment are prepared from the following components: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, scorpio, centipede, earthworm, frankincense, myrrh, notopterygium root, radix angelicae pubescentis, radix clematidis, gentiana macrophylla, lycopodium clavatum, safflower and phryma leptostachya; the decoction is prepared from the following components: eucommia ulmoides, longspur epimedium, radix rehmanniae preparata, raw astragalus membranaceus, teasel root, semen cuscutae, radix achyranthis bidentatae, radix clematidis, salvia miltiorrhiza, radix aconiti preparata, prepared kusnezoff monkshood root, angelica sinensis and liquorice. According to the invention, a treatment mode of combining external use of ointment and oral administration of decoction is innovatively adopted, aiming at the pathogenesis characteristics of rheumatism ostalgia, local symptoms are rapidly relieved through the external ointment, the internal organ function is fundamentally conditioned through the oral decoction, the treatment strategy of treating symptoms in emergency and treating root causes in slow is realized, and the clinical curative effect is remarkably improved.

This invention provides a traditional Chinese medicine composition for clearing the lungs and relieving asthma, its granules, and their applications, relating to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for clearing the lungs and relieving asthma of this invention is prepared from the following raw materials in the indicated weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Apricot Kernel 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon Root 8-12g, Prepared Pinellia Rhizome 8-12g, Tangerine Peel 8-12g, Ginkgo Root 8-12g, Scutellaria Root 13-18g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Peucedanum Root 8-12g, and Belamcanda Rhizome 8-12g. The traditional Chinese medicine formula provided by this invention has good clinical efficacy in treating chronic obstructive pulmonary disease, with high clinical control and efficacy rates, and a high overall effective rate.

The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 280-320 parts of red ginseng; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 580 to 620 parts of rhizoma atractylodis macrocephalae, 280 to 320 parts of rhizoma zingiberis, 80 to 120 parts of sandalwood, 280 to 320 parts of edible tulip, 580 to 620 parts of concha arcae, 580 to 620 parts of oldenlandia diffusa, 180 to 220 parts of notholirion bulbuliferum and 280 to 320 parts of sea buckthron oil. The total effective rate of the traditional Chinese medicine composition for treating chronic atrophic gastritis with intestinal metaplasia is 93%, and the traditional Chinese medicine composition has a remarkable clinical effect on treating chronic atrophic gastritis with intestinal metaplasia clinically.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating adolescent blood and fluid deficiency and heat disturbing type depression disorder and a preparation method and application thereof. The main active ingredients of the traditional Chinese medicine composition include, in mass parts, ginger 3-15 parts, prepared pinellia 6-15 parts, cassia twig 1-15 parts, white peony root 3-15 parts, angelica 3-15 parts, chuanxiong 3-12 parts, radix codonopsis 5-15 parts, north adenosma 3-15 parts, raw licorice 3-15 parts, raw rehmannia 6-24 parts, maimendong 9-27 parts, cortex moutan 3-18 parts, raw gardenia 3-12 parts, fructus aurantii 3-12 parts, gypsum 6-24 parts. The efficacy and safety evaluation research shows that the traditional Chinese medicine composition has a significant clinical effect on adolescent blood and fluid deficiency and heat disturbing type depression disorder and is safe.

The invention discloses a traditional Chinese medicine composition for treating pulmonary interstitial lesion of sicca syndrome and application of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from the following raw material medicines in parts by weight: 8-10 parts of schisandra chinensis, 8-10 parts of radices trichosanthis, 12-15 parts of curcuma zedoary and 12-15 parts of dogwood. Based on the core pathogenesis of'blood stasis obstructing lung collaterals', the traditional Chinese medicine creatively takes blood breaking and blood stasis removal as the treatment principle, and also has the effects of moistening dryness, promoting the secretion of saliva or body fluid, tonifying qi and reinforcing the kidney. In the formula, curcuma zedoary is used as a monarch for breaking blood and dredging collaterals, radices trichosanthis and schisandra chinensis are used as ministerial drugs for moistening dryness and astringing lung, dogwood is used as an assistant and guide for reinforcing kidney and regulating, and the four medicines are The composition can be prepared into decoction, granules and the like, is used for treating pulmonary interstitial lesion of sicca syndrome, can remarkably improve clinical symptoms, lung functions and imaging manifestations of patients, and is high in safety and exact in clinical curative effect.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction and application thereof. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is prepared from the following raw materials: fried semen raphani, fructus aurantii stir-fried with bran, fried fructus aurantii immaturus, raw liquorice, radix paeoniae alba, rheum officinale, rhizoma zingiberis, codonopsis pilosula, bupleurum chinense, ginger-processed cortex magnoliae officinalis and lignum dalbergiae odoriferae. The prescription is based on the core theories of'six internal organs are used for dredging ', 'qi movement is caused by rising and falling' and'healthy energy is strengthened and attacks evil 'in the traditional Chinese medicine, and the prescription aims to dredge triple jiao, smooth qi movement, dredge the internal organs, purge turbidity and strengthen the healthy energy. The whole formula takes'dredging and descending 'as a main component, 'ascending and dispersing' as an auxiliary component and'tonifying 'as an assistant component, so that a precise compatibility system with simultaneous ascending and descending and simultaneous purgation and tonification is formed. The traditional Chinese medicine enema composition is remarkable in clinical curative effect, low in recurrence rate and free of adverse reaction, the preparation process is simple and easy to implement and easy to popularize and apply, and the traditional Chinese medicine enema composition has good social benefits and economic benefits.

The invention belongs to the technical field of biological detection, and discloses a kit for detecting the concentration of human serum C4BP-a and a use method. The kit comprises an antibody for detecting human serum C4BP-a protein, deionized water PBS, a 96-well plate, a well plate covering film, a standard substance, a C4BP-a standard substance diluent, a detection solution A, a detection diluent A, a detection solution B, a detection diluent B, a TMB substrate solution, a stop solution and a concentrated washing solution. The invention provides a brand new marker human serum C4BP-a protein for predicting clopidogrel resistance, and the marker as a detection target can predict or assist in judging the clinical curative effect or prognosis of a patient after taking medicine.

The application belongs to the technical field of medicine detection, and particularly relates to a kind of fingerprint spectrum of qi-regulating and blood-activating preparation and a method for establishing, the qi-regulating and blood-activating preparation is made of Litsea rotundifolia, moxa tablet, chuanxiong, and baiyunqing, the fingerprint spectrum is determined by UPLC-MS method, compared with ordinary liquid chromatography, has the advantages of higher resolution, more sensitive detection, shorter separation time, and more explicit chemical components; at the same time, it is helpful to establish a perfect quality control system of product, and is helpful to guarantee the quality of medicine and clinical efficacy.

The present application relates to a kind of traditional Chinese medicine composition for treating or / and preventing ovarian reserve function reduction and its preparation method and purposes, belong to the field of traditional Chinese medicine.The traditional Chinese medicine composition of the present application is prepared from the following weight ratio of raw materials: mulberry 0.8-1.2 parts, medlar 0.8-1.2 parts, lily 0.8-1.2 parts, bran-fried Chinese yam 1.2-1.8 parts.The present application also provides the preparation method and purposes of the traditional Chinese medicine composition.The traditional Chinese medicine composition of the present application is mainly kidney-filling essence, blood-nourishing and yin-nourishing, and also takes into account lung, spleen and liver, heart-clearing and spirit-soothing.The composition of drug is homologous in medicine and food, with less medicine taste, good efficacy, especially when taking during ovulation induction, with short treatment course.Clinical efficacy observation and animal experiment have proved that, under specific dosage ratio, it can play a synergistic effect.