261 results about "Clinical efficacy" patented technology

The invention discloses an ultra-high dose rate radiotherapy plan optimization system based on compensator modulation, and relates to the technical field of radiotherapy. A data acquisition module is used for acquiring medical image data of a patient and receiving a clinical target; the clinical target comprises a target region prescription dose, an organ-endangering limit and a minimum dose rate threshold value required for triggering and maintaining a FLASH effect; and the FLASH biological effect evaluation module is used for calculating FLASH biological effective dose distribution corresponding to the physical dose distribution through an embedded biological effect model based on the input physical dose distribution and dose rate distribution. According to the method, the physical dose is converted into the accurate FLASH biological effective dose through the improved linear quadratic model embedded with the FLASH correction factor, the target tumor killing effect is guaranteed, normal tissue protection is enhanced with the help of the tissue differentiation correction factor, the industrial pain point that the physical dose reaches the standard but the biological effect does not reach the expectation is effectively solved, and the application prospect is wide. And the treatment plan better meets the clinical curative effect and safety core requirements.

The invention discloses a multi-agent real-world clinical curative effect evaluation and accurate decision-making system, and relates to the technical field of medical data processing. According to the invention, a research demand analysis agent generates a research scheme after understanding the input content of a user and transmits the research scheme to a data management agent, a statistical analysis modeling agent, a result report generation agent, a data security agent and the data management agent privacy and encrypt data uploaded by the user; meanwhile, additional feature construction is carried out according to the research requirement of a user to form brand new analysis data used by a subsequent statistical analysis modeling agent, and after the statistical analysis modeling agent obtains the data, an analysis result is obtained by calling external software and is transmitted to a result report generation agent; and generating a clinical evaluation report together with the research scheme transmitted by the research demand analysis agent. According to the invention, full-process automatic, specialized and safe research support is realized.

The invention provides application of active decapeptide in preparation of a medicine for preventing or treating cerebral apoplexy, and belongs to the technical field of biological medicine, the active decapeptide with the amino acid sequence as shown in SEQ ID NO.1 is applied to prevention or treatment of cerebral apoplexy for the first time, the active decapeptide can effectively inhibit formation of cerebral thrombosis of zebra fish with ischemic cerebral apoplexy, and the active decapeptide can be used for preventing or treating cerebral apoplexy. The brain blood flow supply is recovered; meanwhile, the active decapeptide can significantly reduce the hemorrhagic area and hemorrhagic rate of the zebra fish brain with hemorrhagic stroke, repair brain vascular injury and inhibit the occurrence and development of hemorrhagic stroke. In addition, the active decapeptide has small toxic and side effects, and is of great significance for improving the clinical curative effect of cerebral apoplexy and reducing the medication risk when being used for research and development of novel drugs for resisting cerebral apoplexy.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The invention provides a pulmonary nodule patient treatment prediction method based on artificial intelligence, and the method comprises the steps: obtaining a historical tongue picture feature and a historical pulmonary nodule CT image, extracting a tongue coating color value RGB component, a spatial frequency of a tongue surface texture feature, a gradient value of pulmonary nodule edge sharpness, and a CT value standard deviation of pulmonary nodule density distribution, and obtaining an initial feature set; extracting the change trend of the tongue coating thickness and the pulmonary nodule edge sharpness in the treatment cycle from the weighted feature set, analyzing the dynamic evolution rule of the correlation between the change rate of the tongue coating thickness and the gradient value of the pulmonary nodule edge sharpness, and obtaining a time sequence feature vector in combination with the time rhythm characteristics of the traditional Chinese medicine tongue diagnosis; and carrying out standardization and normalization processing on the fusion feature set, predicting by combining a clinical curative effect evaluation standard and a pulmonary nodule iconography improvement index to obtain the correlation strength of the change rate of the thickness of the tongue coating and the improvement trend of the edge sharpness of the pulmonary nodule in a treatment cycle, and obtaining a predicted curative effect result.

The invention belongs to the technical field of medical monitoring, and provides an inhalation treatment monitoring method and system based on the Internet of Things, and the method comprises the steps: collecting the inhalation flow value and the breath-holding time length of a single treatment behavior of a patient through an intelligent flow speed monitoring device in a jet atomizer, generating an inhalation and breath-holding time sequence, and carrying out the collection of the inhalation flow value and the breath-holding time length; calculating a pseudo-compliance evaluation value to judge whether pseudo-compliance exists or not, if so, analyzing the relevance between the pseudo-compliance evaluation value and the pseudo-compliance evaluation value through a distance correlation coefficient, during relevance, constructing an influence capture model by using an attention mechanism-residual network model, outputting an influence coefficient, and performing positive and negative coordination analysis; according to the method, the mist amount and the flow speed are adjusted based on the standard range and the influence coefficient, accurate evaluation of false compliance is achieved, effectiveness and controllability of inhalation treatment are improved through correlation analysis and parameter linkage optimization, the method is suitable for inhalation treatment equipment such as a jet atomizer, and improvement of treatment compliance and clinical curative effect of a patient is facilitated.

The invention discloses a radix astragali, rhizoma polygonati and ligustrum lucidum ait traditional Chinese medicine preparation for treating myelosuppression as well as a preparation method and a detection method thereof. The preparation is prepared from 50-150 parts of radix astragali, 50-150 parts of wine-processed rhizoma polygonati, 25-75 parts of wine-processed ligustrum lucidum ait, 50-150 parts of blanched rhizoma drynariae, 50-150 parts of radix trichosanthis and 25-75 parts of herba epimedii. The optimal extraction process and refining process are screened out based on effective components and pharmacological activity through a large number of tests, and the optimal preparation process of the Shuanghuangliangwhitening oral liquid and other traditional Chinese medicine preparations is obtained through stability investigation and verification. According to the invention, a thin layer chromatography is adopted, the four medicinal materials of astragalus membranaceus, glossy privet fruit, rhizoma drynariae and herba epimedii are respectively subjected to thin layer chromatography research, and methodology research shows that the method is stable and feasible. The invention establishes a content determination method for astragaloside, calycosin-7-glucoside, specnuezhenide and icariin, establishes a quality standard, and has important significance for ensuring the clinical curative effect and safety of astragaloside, calycosin-7-glucoside, specnuezhenide and icariin.

The invention discloses a rehabilitation equipment fault data monitoring method and system, and particularly relates to the technical field of electric digital data processing, comprising the following steps: S1, synchronously acquiring equipment operation time sequence data and patient interaction time sequence data, S2, performing feature extraction and adaptive fusion on the two types of data, and S3, acquiring the data of the equipment operation time sequence and the patient interaction time sequence; s3, equipment health prediction and rehabilitation curative effect deviation prediction are executed in parallel based on the fusion features, and the relevance of the equipment health prediction and the rehabilitation curative effect deviation prediction is analyzed through a cross attention mechanism, and S4, a personalized dynamic baseline model is combined, and an equipment fault risk value, a curative effect deviation degree and a relevance confidence degree are integrated to generate hierarchical monitoring feedback. According to the invention, by constructing an equipment-patient-curative effect ternary closed-loop analysis framework, the spanning from pure fault early warning to treatment effectiveness guarantee is realized, the problems of single monitoring dimension and unhooking with clinical curative effect in the prior art are solved, and the method has the outstanding effects of strong early warning perspectiveness, low false alarm rate and support of root cause analysis.

The invention provides a traditional Chinese medicine preparation quality detection method and system based on multi-dimensional data analysis, and belongs to the technical field of traditional Chinese medicine preparation quality detection. The method comprises the following steps: acquiring mass spectrum data and nuclear magnetic resonance data of various active components in a preparation to generate a multi-dimensional chemical characteristic data set; synchronously collecting corresponding data of the medicinal raw materials, and constructing a process and environment association database; constructing a chemical and process coupling analysis model; and monitoring the production process in real time to obtain the dynamic chemical fingerprint spectrum. By constructing a full-component chemical map and associating the full-component chemical map with process and environmental parameters and combining clinical curative effect data to establish a drug effect and component response curved surface model, the limitation that only a few index components are concerned in traditional detection is broken through, so that a detection result can accurately reflect the multi-target and overall regulation characteristics of the traditional Chinese medicine preparation, and the detection accuracy is improved. The problem that the components are qualified but the curative effect is poor due to single detection dimension is avoided, and the relevance between quality detection and the clinical curative effect is remarkably improved.

This invention discloses a composite nanozyme that enhances the clinical efficacy of oxaliplatin, its preparation method, and its application. The composite nanozyme consists of indium ruthenium nanozyme and an iliximab embedding and anchoring layer. The indium ruthenium nanozyme consists of indium ruthenium nanoparticles and a carbon-nitrogen framework, with the indium ruthenium nanoparticles loaded on the surface and within the pores of the carbon-nitrogen framework. The iliximab embedding and anchoring layer consists of a dithiol polyethylene glycol coating layer and iliximab. Preparation method: ZIF-8 is prepared by co-precipitation of zinc salt methanol solution and 2-methylimidazole methanol solution, followed by calcination to obtain the carbon-nitrogen framework. The carbon-nitrogen framework dispersion is then stirred in an oil bath with indium nitrate solution and ruthenium trichloride solution to prepare a nanozyme precursor, followed by calcination to obtain indium ruthenium nanozyme. The indium ruthenium nanozyme is dispersed in a dithiol polyethylene glycol solution, and iliximab solution is added dropwise. The resulting solid product is then dried. This invention can solve problems such as strong drug tolerance, insufficient intracellular accumulation, and severe tumor immunosuppression in oxaliplatin treatment.

The invention relates to the technical field of biomedical information, in particular to an umbilical cord mesenchymal stem cell donor matching database construction method based on HLA (human leukocyte antigen) typing, which comprises the following steps of: recording and storing data of a donor in a database to finish initial construction of the database; regularly rechecking the donor data record stored in the database, and updating the state identifier of the donor data record when the rechecked data is changed by a preset degree; and receiving a matching request containing the human leukocyte antigen typing data of the target patient and the target disease type, performing donor screening in the database by using a preset comprehensive matching degree model based on the matching request, and optimizing parameters of the comprehensive matching degree model through a machine learning model based on the matching record and the clinical curative effect data corresponding to the matching record. According to the method, the accuracy and effectiveness of umbilical cord mesenchymal stem cell treatment are improved, and meanwhile, the system has continuous self-evolution ability.

The application belongs to the field of medicine, and particularly relates to application of a Danzhu Fuguan formula in preparation of a drug for treating idiopathic membranous nephropathy (IMN). The Danzhu Fuguan formula comprises the following raw materials in parts by weight: 25-35 parts of Danshen, 10-15 parts of Baizhu, 25-35 parts of Huangqi, 10-20 parts of Jinyinhua, 10-20 parts of Hujiang, 10-20 parts of Yujin, 10-15 parts of Fuling, 25-35 parts of Yiyiren and 10-15 parts of Qianghuo. Research shows that the Danzhu Fuguan formula can effectively reduce the 24-hour urine protein level of IMN patients, and the 24-hour urine protein level shows a significant downward trend with the extension of the treatment course; according to the IMN clinical efficacy standard, the total remission rate of patients receiving the Danzhu Fuguan formula treatment for 3 months is 37%, the total remission rate of patients receiving the treatment for 6 months is 50%, and the total remission rate of patients receiving the treatment for 12 months reaches 72%, and the remission rate increases significantly with the extension of the treatment course.

The invention relates to a traditional Chinese medicine composition for treating or / and preventing hypoovarian reserve function as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of mulberries, 0.8-1.2 parts of Chinese wolfberry fruits, 0.8-1.2 parts of lily bulbs and 1.2-1.8 parts of Chinese yams stir-fried with bran. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition mainly tonifies kidney and replenishes essence, nourishes blood and yin, gives consideration to lung, spleen and liver, clears away heart fire and tranquillizes the mind, is homologous in medicine and food, few in medicine flavor and good in medicine effect, and is especially short in treatment course when being taken during ovulation promotion. Clinical curative effect observation and animal experiments both prove that under the specific dosage ratio, the synergistic interaction effect can be achieved.

The invention discloses a vaccine platform for in-vivo in-situ generation of CAR-T cells as well as a preparation method and application of the vaccine platform, and belongs to the technical field of biological medicines. In order to solve the problems that in the prior art, a CAR-T cell therapy is complex in preparation process, high in cost, poor in durability and poor in curative effect in clinical application of solid tumors, the invention provides a vaccine platform for generating CAR-T cells in vivo in situ, and the vaccine platform is composed of an mRNA delivery vector for expressing antigens; the carrier is an mRNA (messenger Ribonucleic Acid) nano-carrier of which the surface is modified with a specific antigen and which loads and encodes CAR; the vaccine platform is a universal mRNA delivery platform, provides a new universal strategy for enhancing the clinical effect of a CAR-T cell therapy, and has a wide application prospect.

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

The application discloses a method for simultaneously determining phenolic acid and tanshinone components in Danshen injection, and according to the structure and property characteristics of the phenolic acid and tanshinone components, the best mobile phase composition, elution program, flow rate, chromatographic column and mass spectrometry condition are screened through a large number of experiments. Experimental verification shows that the UPLC-TQ-MS / MS method can simultaneously determine 11 different structure and type of phenolic acid and tanshinone component compounds, and the methodological verification shows that the detection method has good precision, repeatability and high accuracy, and has important significance for controlling the quality of Danshen injection and guaranteeing the clinical curative effect.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating lower limb arteriosclerosis obliterans, which is technically characterized by being prepared from ten medicinal materials, namely red ginseng, astragalus membranaceus, cassia twig, morinda officinalis, cistanche deserticola, salvia miltiorrhiza, pseudo-ginseng, radix cyathulae, sargentgloryvine stem and semen brassicae according to a specific weight part ratio. Aiming at the core pathogenesis of yang deficiency and blood stasis of lower limb arteriosclerosis obliterans, the composition disclosed by the invention provides a treatment method of tonifying qi, warming yang, promoting blood circulation to remove blood stasis, removing speckles and dredging vessels, the compatibility of the whole formula is rigorous, and monarch, minister, assistant and guide are clear; moreover, the composition can be prepared into capsules or granules, is used for treating yang deficiency and blood stasis type lower limb arteriosclerosis obliterans, has an exact clinical curative effect, can remarkably improve symptoms of patients and lower limb blood flow, and is good in safety.

The invention discloses a method for establishing a fingerprint spectrum of a diaphoresis and antipyretic preparation, which comprises the following steps: preparing a test solution, and carrying out high performance liquid chromatography detection on the test solution, the test solution is prepared by the following steps: adding 65-75% of methanol or ethanol into a diaphoresis and anti-pestilence preparation, and carrying out ultrasonic treatment; the high performance liquid chromatography detection adopts gradient elution, and the gradient elution procedure is as follows: 0-15 min, 6-12% A; 12% A is changed into 20% A, and 20%-22% A is changed into 20% A after 15 min to 45 min and 45 min to 65 min; when the time is 65-85 minutes, 22% A is changed into 70% A; the fingerprint spectrum of the diuresis and antipyretic granules established by the invention can be used for objectively, comprehensively and accurately evaluating the quality of the diuresis and antipyretic granules, and has important significance for controlling the quality of diuresis and antipyretic granules and ensuring the clinical curative effect.

The invention discloses a multifunctional physical therapy device for internal medicine of traditional Chinese medicine, and relates to the technical field of medical instruments, four rollers, a layered meshing type rigidity mechanical switching assembly and a tension and humidity cooperative sensing assembly, and the layered meshing type rigidity mechanical switching assembly and the tension and humidity cooperative sensing assembly are both arranged on one side of the outer wall of the four rollers. The tension and humidity cooperative sensing assembly is arranged at the bottom of the layered meshing type rigidity mechanical switching assembly, and the layered meshing type rigidity mechanical switching assembly comprises an adjusting knob and a rotating shaft. The full-process upgrading of traditional Chinese medicine internal medicine physical therapy from static adaptation to dynamic adaptation and from experience regulation and control to precise quantification is achieved, the full-process upgrading is different from a traditional passive drug delivery scheme depending on fixed rigidity fitting, static flow output and manual intervention, and the drug permeation process better fits individual differences, better responds to dynamic working conditions, better guarantees clinical curative effects and is higher in universality.

This invention provides the application of IGF2BP3 as a target in the preparation of therapeutic drugs for fusion gene leukemia, specifically in the preparation of mRNA-highly stable fusion gene leukemia. The highly stable mRNA fusion genes include, but are not limited to, PAX5-ETV6 and STK38-PXT1 fusion genes. The drugs include IGF2BP3 gene-specific interfering RNA and IGF2BP3 inhibitors, including but not limited to venetoclax. This invention is the first to propose the use of IGF2BP3-targeted drugs for the treatment of mRNA-highly stable fusion gene leukemia; it not only reveals the role of IGF2BP3 in the oncogenic function of fusion genes but also provides a new therapeutic target and effective drug for this type of fusion gene leukemia, offering the possibility of further improving the clinical efficacy, prognosis, and survival of leukemia patients.

The application discloses a composition and a preparation method of a ripretinib cream, and the composition comprises: an active ingredient of ripretinib or a pharmaceutically acceptable salt thereof and excipients, wherein the excipients are composed of an oily base, a humectant, an emulsifier, water, a thickening agent, a preservative and a chelating agent, etc. The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM . The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM .

The invention discloses a pharmaceutical composition for treating cardiovascular blockage diseases and cognitive impairment and new application thereof.The pharmaceutical composition is a traditional Chinese medicine compound heart-tonifying and mental-tranquilizing formula, and the compound has the effects of tonifying qi, activating blood, dispersing blood stasis, replenishing essence, nourishing yin and the like; the traditional Chinese medicine composition can be used for integrally intervening a plurality of pathological links of cardiovascular blockage diseases such as myocardial infarction and cognitive impairment diseases such as Alzheimer's disease, not only can improve the functions of the heart and the brain, but also can obviously improve the life quality of a patient, achieves a good clinical curative effect, and does not have obvious adverse reaction.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating ejection fraction retention heart failure, which is technically characterized by comprising the following components in parts by weight: 8-10 parts of ginseng, 15-20 parts of salvia miltiorrhiza, 10-12 parts of radix polygonati officinalis, 10-15 parts of rhodiola rosea, 5-10 parts of pseudo-ginseng, 10-15 parts of turmeric, 15-17 parts of bighead atractylodes rhizome, 15-17 parts of poria cocos and 10-12 parts of centella asiatica. , 10-12 parts of herba lycopi and 10-12 parts of semen lepidii. Through systematic clinical observation and practice, the composition provided by the invention can obviously improve the clinical curative effect of a patient, improve traditional Chinese medicine syndromes, diastolic function indexes and exercise tolerance, and improve life quality; and the kit has a positive clinical application value for patients with clear diagnosis, accurate syndrome differentiation and good indication mastering.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a milrinone-citric acid monohydrate co-crystal. The application provides a new milrinone-citric acid monohydrate co-crystal and a preparation method thereof. The co-crystal has excellent properties, can significantly enhance the solubility and stability of milrinone, is helpful to improve the oral bioavailability, improve the clinical curative effect, has strong drug-making value, the preparation method is simple in operation and easy to control, and is suitable for industrial amplification.

The present invention relates to a method for constructing a characteristic spectrum of a Qi-invigorating and blood-reinvigorating preparation, as well as its characteristic spectrum and application. By adopting specific high-performance liquid chromatography (HPLC) detection and analysis conditions for the Qi-invigorating and blood-reinvigorating preparation, a characteristic spectrum of the Qi-invigorating and blood-reinvigorating preparation containing multiple characteristic peaks is constructed. The method for constructing the characteristic spectrum of the Qi-invigorating and blood-reinvigorating preparation has the advantages of good stability, high precision, good repeatability, etc. after methodological verification. It can comprehensively reflect the effective ingredients contained in the Qi-invigorating and blood-reinvigorating preparation, and further objectively, comprehensively and accurately evaluate the quality of the Qi-invigorating and blood-reinvigorating preparation, which is of great significance for controlling the quality of the Qi-invigorating and blood-reinvigorating preparation and ensuring the clinical efficacy.

The invention discloses a traditional Chinese medicine compound composition for treating insomnia and a quality detection method thereof. The traditional Chinese medicine compound composition is prepared from cassia twig, dried ginger, schisandra chinensis, raw Chinese yam, cortex moutan, inula flower, lophatherum gracile, ginger processed pinellia, raw coix seed, raw oyster shell and cortex albiziae. According to the pathogenesis characteristics of insomnia and the principle of syndrome differentiation and treatment of traditional Chinese medicine, the optimal raw material composition and dosage part ratio are screened out through a large number of experiments, the prepared traditional Chinese medicine compound can nourish the liver, calm the heart and regulate the spirit, can improve clinical symptoms such as short-term insomnia disorder, dizziness, palpitation, sweating and restlessness, and has a wide application prospect. The clinical curative effect of treating insomnia is obviously improved. Thin-layer chromatography qualitative identification and high performance liquid chromatography are adopted for quantitative detection, the content of active ingredients of the rhizoma zingiberis, the Chinese yam, the moutan bark and other medicinal materials in the formula is comprehensively and objectively detected and analyzed, and methodological detection shows that the high performance liquid chromatography provided by the invention is high in precision and good in repeatability and stability.

This invention relates to a method for preparing genetically modified cells. Specifically, this invention provides a method for preparing genetically modified immune cells. This cell preparation method can rapidly prepare immune cells of high quality, thereby ensuring clinical efficacy.

The invention relates to the technical field of modern preparations of medicinal and edible medicinal diets, in particular to a lily and kumquat traditional Chinese medicine ointment special for pregnant women to relieve cough and moisten the lung and a preparation process thereof, the lily and kumquat traditional Chinese medicine ointment is prepared from kumquat, Lanzhou sweet lily, Xinhui pericarpium citri reticulatae and other components, and also contains a kumquat flavonoid glycoside-cyclodextrin inclusion compound and a lily polysaccharide-zinc complex; carrying out ultrasonic extraction on flavonoid glycoside from kumquats, then carrying out inclusion with cyclodextrin, complexing lily polysaccharide with zinc, and carrying out microencapsulation on the folium eriobotryae extract; the raw materials and Chinese yam water are mixed, decocted and concentrated, active ingredients are added for compounding, and crystallization is performed after homogenization and sterilization to obtain the ointment. The ointment improves the content and stability of effective components through inclusion, complexation and microencapsulation technologies, is high in 24-hour slow release rate, quick in effect taking, high in clinical effective rate, good in taste, free of additives and suitable for pregnant women, and achieves safe and effective cough relieving.

The invention relates to cellulose derivative matrigel and application thereof in a tumor CDX or PDX model, the cellulose derivative matrigel is a ready-to-use hydrogel free of animal-derived components, can be used for constructing an efficient and stable tumor CDX or PDX model, is simple to operate, has high similarity with clinical tumors, and can be used for preparing the tumor CDX or PDX model. And a solution is provided for clinical curative effect prediction and preclinical research.