System and method for asynchronous distributed optimization of an enterprise. The system includes multiple computer systems coupled over a network, which store and implement multiple models, including one or more dynamic models representing respective sub-systems or processes of the enterprise. At least two of the models are interdependent. The system also includes an optimizing system that includes multiple optimizers, at least two of which are interdependent, and constraints and/or objectives, and is operable to receive information related to the enterprise from multiple information sources, and use one or more of the plurality of models to generate a solution subject to the one or more constraints and/or objectives, which is usable in managing the enterprise. Some or all of the system operates in an asynchronous manner. Various portions of the system, e.g., the models, data sources, optimizers, constraints and/or objectives, etc., may be updated, e.g., asynchronously, as desired.