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The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A device and method for spatially resolved photodetection and demodulation of temporally modulated electromagnetic waves makes it possible to measure phase, amplitude and offset of a temporally modulated, spatially coded radiation field. A micro-optical element (41) spatially averages a portion (30) of the scene and equally distributes the averaged intensity on two photo sites (51.1.51.2) close to each other. Adjacent to each of these photo sites (51.1) are two storage areas (54.1, 54.2) into which charge from the photo site can be moved quickly (with a speed of several MHz to several tens or even hundreds of MHz) and accumulated essentially free of noise. This is possible by employing the charge-coupled device (CCD) principle. The device combines a high optical fill factor, insensitivity to offset errors, high sensitivity even with little light, simultaneous data acquisition, small pixel size, and maximum efficiency in use of available signal photons for sinusoidal as well as pulsed radiation signals. The device and method may be used in a time-of-flight (TOF) range imaging system without moving parts, offering 2D or 3D range data.

A UV irradiation apparatus for processing a semiconductor substrate includes: a UV lamp unit; a reaction chamber disposed under the UV lamp unit; a gas ring with nozzles serving as a first electrode between the UV lamp unit and the reaction chamber; a transmission window supported by the gas ring; an RF shield which covers a surface of the transmission window facing the UV lamp unit; a second electrode disposed in the reaction chamber for generating a plasma between the first and second electrodes; and an RF power source for supplying RF power to one of the first or second electrode.

The invention provides a method and apparatus for sealing tissue for applications in such cases where there is a benefit to having an additional sealing capability. In this regard, the preferred embodiment of the invention, in addition to thermal sealing, or alternatively, incorporates a stapling cartridge or similar sealing mechanism into a surgical electrocautery device of the type that is used to seal and dissect long sections of connective tissue that secure organs or segments of organs.

A method of virtualizing memory through shadow page tables that cache translations from multiple guest address spaces in a virtual machine includes a software version of a hardware tagged translation look-aside buffer. Edits to guest page tables are detected by intercepting the creation of guest-writable mappings to guest page tables with translations cached in shadow page tables. The affected cached translations are marked as stale and purged upon an address space switch or an indiscriminate flush of translations by the guest. Thereby, non-stale translations remain cached but stale translations are discarded. The method includes tracking the guest-writable mappings to guest page tables, deferring discovery of such mappings to a guest page table for the first time until a purge of all cached translations when the number of untracked guest page tables exceeds a threshold, and sharing shadow page tables between shadow address spaces and between virtual processors.

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and/or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and/or sequence information. In certain embodiments the sequence information is stored in a database.

Field programmable gate arrays (FPGA's) may be structured in accordance with the disclosure to have a register-intensive architecture that provides, for each of plural function-spawning LookUp Tables (e.g. a 4-input, base LUT's) within a logic block, a plurality of in-block accessible registers. A register-feeding multiplexer means may be provided for allowing each of the plural registers to equivalently capture and store a result signal output by the corresponding, base LUT of the plural registers. Registerable, primary and secondary feedthroughs may be provided for each base LUT so that locally-acquired input signals of the LUT may be fed-through to the corresponding, in-block registers for register-recovery purposes without fully consuming (wasting) the lookup resources of the associated, base LUT. A multi-stage, input switch matrix (ISM) may be further provided for acquiring and routing input signals from adjacent, block-interconnect lines (AIL's) and/or block-intra-connect lines (e.g., FB's) to the base LUT's and/or their respective, registerable feedthroughs. Techniques are disclosed for utilizing the many in-block registers and/or the registerable feedthroughs and/or the multi-stage ISM's for efficiently implementing various circuit designs by appropriately configuring such register-intensive FPGA's.

A new general method for building hybrid processors achieves higher performance in applications by allowing more powerful, tightly-coupled instruction set extensions to be implemented in reconfigurable logic. New instructions set configurations can be discovered and designed by automatic and semi-automatic methods. Improved reconfigurable execution units support deep pipelining, addition of additional registers and register files, compound instructions with many source and destination registers and wide data paths. New interface methods allow lower latency, higher bandwidth connections between hybrid processors and other logic.

The invention concerns a method for determining whether to grant access of a user equipment (UE) to a radio access network in a present position of the user equipment (UE) within a communications system. The communications system comprises a control node (N1, N2) handling services for the user equipment (UE) and an access node (AN1, AN2) controlling the access network. The method is initiated by receiving a request for service processing for the user equipment (UE) in the control node (N1, N2) with an identification of the user equipment (UE). A subscriber group information is determined for the user equipment (UE) according to the identification of the user equipment and sent to the access node (AN1, AN2). Furthermore, an area access information according to the present location of the user equipment (UE) is determined in the access node (AN1, AN2). The access granting of the user equipment (UE) to the radio access network is performed according to a logical combination of the subscriber group information and the area access information. A communication network, nodes and software programs embodying the invention are also described.

To avoid a fixed assignment of wide-area mobile communication units to components of a container surveillance system for increase of reusability, there is provided a mobile communication device for surveillance of at least one transported unit being carried by a tansporting unit, comprising a short range data communication unit (30) adapted to a short range wireless data exchange with at least one tag attached to the transported unit; a long range data communication unit (32) adapted to a long range wireless data exchange to a transport surveillance system; wherein communication unit the mobile communication unit is fixed to operating equipment of the transported unit or to the transporting unit during surveillance of the transported unit and is detachable from the transported unit or the transporting unit when the transported unit must not be surveyed.

A transceiver employing a steerable phased-array antenna includes a modem architecture in which signals from each antenna element in the array are independently processed down to the individual baseband channel level, and digital beamforming is performed at baseband. The data rate reduction from IF to baseband permits parallel signal data from multiple antenna elements to be time multiplexed and serially processed at acceptable data rates at baseband with minimal modem hardware requirements. Both for transmit signal modulation and received signal demodulation, the computation of carrier tracking, automatic gain control (AGC)/power-control, and beamforming are shared by the same processing circuitry for all channels when performed at baseband. The resulting baseband circuitry is only incrementally larger than that required for carrier tracking and AGC alone, yet accomplishes independent beamforming for each antenna element on each user channel.

A flexible and relatively hardware efficient LDPC encoder is described. The encoder can be implemented with a level of parallelism which is less than the full parallelism of the code structure used to control the encoding process. Each command of a relatively simple microcode used to describe the code structure can be stored and executed multiple times to complete the encoding of a codeword. Different codeword lengths can be supported using the same set of microcode instructions but with the code being implemented a different number of times depending on the lifting factor selected to be used. The LDPC encoder can switch between encoding codewords of different lengths, without the need to change the stored code description information, by simply changing a code lifting factor used to control the encoding processes. When coding codewords shorter than the maximum supported codeword length some block storage locations and/or registers may go unused.

An apparatus and method for providing a virtual graffiti function and a recording medium for the same. The apparatus for providing a virtual graffiti function includes: a touch-screen display for displaying information on its screen, and at the same time receiving user-entry data created by a user touching the screen; and a controller connected to the touch-screen display, which overlaps a graffiti screen image with a main screen image in a virtual graffiti area for providing a portion of the screen with virtual graffiti, classifies the user-entry data created by the user touching the screen into application execution entry data and graffiti entry data according to the touched position and/or method, and processes the classified user-entry data differently from each other. Therefore, the apparatus can effectively implement a graffiti function in a hand-held device limited in size, and can also provide an effective recording medium.