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460results about How to "Improve translation" patented technology

System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology

The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
Owner:NATERA

Skull mounted electrode lead securing assembly

An assembly for securing an electrode lead within a burr hole formed in a patient's skull. The assembly is provided for reliably, easily, and reversibly securing an implanted electrode lead such that the active portion of the lead which is inside the brain tissue within the skull is not subject to unwanted translations when the external portion of the lead is manipulated. The securing assembly has two separate components. The first is a bone port which seats within a preformed burr hole in the skull. The bone port is a cylindrical shaped short tube which includes a means for gripping the skull on the external periphery of the cylinder. The central axial hole of the port is designed to receive the second lead-locking portion of the assembly. The external surface of the lead-locking portion and the interior surface of the central axial hole of the port include an easily engageable coupling means, for example a bayonet locking mechanism. The lead-locking portion has a central electrode passage through which the electrode lead may slide freely in an unlocked disposition. The upper section of the lead-locking portion includes a sliding member which may be selectively manipulated between a closed and open position. The sliding member has a lateral edge which, when the member is moved into the closed position, partially occludes the electrode passage such that an electrode is secured by friction in the passage, thus preventing movement of the active implanted portion of the electrode within the skull. The external portion of the electrode, however, can be manipulated freely.
Owner:ELECTRO CORE TECH

Vectors having enhanced expression and methods of making and uses thereof

Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a transcription factor or a translation factor or a transcription factor and a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector, or at different loci. The second nucleic acid molecule can encode: one transcription factor or more than one transcription factor; or one translation factor or more than one translation factor; or at least one transcription factor and at least one translation factor. The transcription factor can be from vaccinia H4L, D6, A7, G8R, A1L, A2L, H5R, or combinations thereof. The translation factor can be from a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus, e.g., NYVAC, or ALVAC.
Owner:VIROGENETICS
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