2112results about How to "Reduce problems" patented technology

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

Virtual machines of a virtual data center generate runtime instances with a software image, hardware configuration, management configuration and user/service configuration. Virtual data center resource use is monitored by reference to the management configuration of runtime instances, such as for environmental controls like power, cooling and balancing, or for policy limitations on users, software or hardware. Users or services generate runtime instances of stored virtual machines by reference to the user/service configuration, such as pricing or priority. In one example embodiment, the virtual machine software image comprises an application system preparation file that populates a read only application image common to plural virtual machines. Information unique to each virtual machine with respect to the application is maintained in the user/service configuration of the virtual machine and version information is maintained in the management configuration of the virtual machine. Updates to the application across each virtual machine are performed by updating the read only image or any of its configuration information for hardware configuration, management configuration or user/service configuration.

Virtual machines of a virtual data center generate runtime instances with a software image, hardware configuration, management configuration and user/service configuration. Virtual data center resource use is monitored by reference to the management configuration of runtime instances, such as for environmental controls like power, cooling and balancing, or for policy limitations on users, software or hardware. Users or services generate runtime instances of stored virtual machines by reference to the user/service configuration, such as pricing or priority. In one example embodiment, the virtual machine software image comprises an application system preparation file that populates a read only application image common to plural virtual machines. Information unique to each virtual machine with respect to the application is maintained in the user/service configuration of the virtual machine and version information is maintained in the management configuration of the virtual machine. Updates to the application across each virtual machine are performed by updating the read only image or any of its configuration information for hardware configuration, management configuration or user/service configuration.

An apparatus for optimizing communications between session border controllers in a network environment is provided that includes a session border controller (SBC) operable to communicate with a first endpoint and a second endpoint. The SBC is also operable to communicate with a data path border element (DBE) and a signaling path border element (SBE). The DBE is operable to provide a media relay for a communication session involving the endpoints, the media relay being invoked by either of the endpoints using a traversal using relay network address translation (TURN) protocol, which allows the SBC to operate in either of two modes depending on protocol support present in the endpoints.

A method for providing a quality of service in a network environment is provided that includes receiving communication session information associated with a packet data protocol (PDP) link for an end user. The communication session information may be mapped to the end user in order to generate a quality of service attribute to be communicated to a next destination.

Information handling system network addresses are managed to support a consistent MAC address for iSCSI and fibre channel host bus adapter. For example, a management controller retrieves a MAC address from persistent memory, such as a network location, and assigns the MAC address to a non-persistent memory of a predetermined information handling system network component so that the MAC address remains consistent even if the network component is replaced. For example, an offload engine that supports network communications with iSCSI receives a MAC address from a network location and applies the MAC address for use by a host bus adapter. Alternatively, an offload engine supports Fibre Channel with World Wide Name or World Wide Identifier address assignments.

A method for executing a video conference is provided that includes receiving one or more audio streams associated with a video conference from one or more end points and determining an active speaker associated with one of the end points. Audio information associated with the active speaker may be received at one or more media switches. One or more video streams may be suppressed except for a selected video stream associated with the active speaker, the selected video stream propagating to one or more of the media switches during the video conference. The selected video stream may be replicated such that it may be communicated to one or more of the end points associated with a selected one of the media switches.

A vertebral stabilization assembly for stabilizing vertebrae is provided. The vertebral stabilization assembly includes a first and a second pedicle screw, a first and second connecting screw, and a connecting member. The first and second pedicle screws each have a shaft provided with a threaded portion operable for threading engagement of the first and second pedicle screws with a first and second vertebra, respectively, each shaft also has an engaging portion. The first and second connecting screws each have a first end adapted to be received by the engaging portions of the first and second pedicle screws, respectively. The connecting member has a first end connected to the first connecting screw and a second end connected to the second connecting screw for stabilization of the first and second vertebra. A guide member for placement of the connecting screw and method for anteriorly stabilizing vertebrae is also provided.

A magnetic latching system selectively couples and releases an information handling system housing and lid by moving a magnet associated with one of the housing or lid relative to a ferrous metal in the other of the housing or lid to selectively apply magnetic attraction between the housing and lid. A latch retainer interfaced with the magnetic latching system retains the magnetic latch in a released position until the lid and housing approach a closed position and then allows the magnetic latch to return to a locked position, thus bringing the lid and housing to a securely closed configuration without slamming together due to the magnetic attraction between the magnet and ferrous metal.

A computer implemented method for providing location-based services using a mobile device is provided. A location of a mobile device is automatically determined. A user context is generated based at least on a user preference and the automatically determined location of the mobile device, wherein the user preference represents at least a content interest of a user. A request is made to a computer remote from the location of the mobile device for an available service relevant to the user context and compatible with a capability of the mobile device. The available service is executed using the mobile device.

An information technology enclosure has a processing subsystem and infrastructure subsystem in separate shipping containers that cooperate to process information. The processing subsystem has increased information processing density by concentrating information handling systems in a first processing shipping container that is supported with infrastructure equipment in a second infrastructure shipping container. In one embodiment, the shipping containers are arranged in a stacked configuration so that cooled air and exhausted air are exchanged through aligned vents formed in the ceiling and floor of stacked shipping containers.

A system for controlling a railroad train over a segment of track. The system comprises a first element for determining a location of the train on the segment of track; a second element for providing track characterization information for the segment of track; the track characterization information related to physical conditions of the segment of track; and a processor for controlling applied tractive forces and braking forces of the train responsive to the location of the train and the track characterization information to reduce at least one of wheel wear and/or track wear during operation of the train over the segment of track.

Heterogeneous resources, such as video conference, audio conference, network, conference room and catering resources, are scheduled through a uniform interface to satisfy a meeting organizer's constraints to have a properly configured meeting with selected of the heterogeneous resources. A prioritized list of sets of heterogeneous resources is determined for scheduling of a selected set, such as the set having the least estimated cost. Automated scheduling tracks resource availability, restricts access to predetermined resources, ensures that rescheduling results in a proper configuration, notifies attendees in an individualized manner, and initiates resource use according to the schedule.

A process for lubricating a container, such as a beverage container, or a conveyor for containers, by applying to the container or conveyor, a thin continuous, substantially non-dripping layer of a liquid lubricant. The process provides many advantages compared to the use of a conventional dilute aqueous lubricant.

An event tracking system tracks customer interactions to obtain product information that are made across plural contact mediums and displays an intuitive directed graph for analysis of the customer interactions. Each customer interaction is logged at each contact medium with a labeled reference associated with the content of the interaction, a time stamp and an identifier for the product or product user. An event modeling engine analyzes the log to identify contact sessions as contacts by the same identifier within a predetermined time so that an event tracking graphical user interface module prepares each contact session for display as a path of nodes interconnected by edges. Selected directed graph characteristics are highlighted, such as transitions from one contact medium to another or contact session volumes associated with an edge that have a relative volume compared with other contact sessions.

An operating system has security updates preintegrated to reduce vulnerability of the operating system to malicious programs, such as worms. Preintegration writes update files over corresponding operating system files before boot of the operating system so that malicious programs are not provided an opportunity to attack the operating system during a post-boot security update. An update package extracts update files, such as QFE files, and prepares the update files within a file and directory structure corresponding to the operating system. An overwrite engine running on an alternative operating system writes the update files to the operating system so that the operating system boots secure from attack by worms that the updates are intended to prevent.