416 results about "Flow cell" patented technology

The embodiment of the invention provides a concentration measuring device and a concentration measuring method. The concentration measuring device comprises a light source module, a plurality of flow cells, a light splitting and on-off module and a processing and control module. The light splitting and on-off module is used for splitting light emitted by the light source module into multiple paths of incident light and transmitting the incident light to the flow cells, and meanwhile one of the characteristic light output by the flow cells can be selected to be transmitted to the processing and control module. And the processing and control module receives the concentration value of the flow cell corresponding to the characteristic light output. According to the concentration measuring device provided by the embodiment of the invention, by arranging the light splitting and on-off module, it is ensured that only the characteristic light output by one flow cell can be transmitted to the processing and control module at any moment, and the characteristic light data of the flow cell at each process point can be sequentially obtained through light path switching, so that monitoring of the concentration of a plurality of process points is realized; the equipment cost can be saved, the system structure is simplified, the maintenance amount is reduced, and the operation difficulty is reduced.

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

The invention discloses a dynamic leaching-spectrophotometric detection method for the release rate of nutrients in a slow-release fertilizer, and relates to the field of agrochemical analys.The detection method comprises the following steps that S1, a slow-release fertilizer sample is placed in a leaching column to be leached, and leachate is collected; s2, sequentially adding a masking agent solution and a chromogenic reagent into the leachate, and carrying out chromogenic reaction; s3, pumping the solution into a double-optical-path flow cell, and measuring absorbance values under a target nutrient characteristic absorption wavelength and a background interference characteristic wavelength; s4, calculating the corrected net absorbance; and S5, calculating the nutrient concentration, and drawing a nutrient release kinetic curve. By adopting a dual-wavelength synchronous detection and real-time dynamic subtraction correction algorithm, the method can eliminate system errors of time-varying background chromaticity, so that accurate and reliable absorbance readings can be obtained at the initial stage of nutrient release even if the nutrient concentration in the leachate is very low, thereby ensuring the authenticity of the initial stage of a release curve and improving the accuracy of nutrient release. And initial release kinetic parameters are accurately captured.

The invention discloses an activated sludge fluorescence online detection device based on a flow cell, and relates to the field of activated sludge biomass detection.The activated sludge fluorescence online detection device comprises a fluorescence spectrophotometer and a fluorescence spectrophotometer sample table arranged on the fluorescence spectrophotometer, and the fluorescence spectrophotometer is connected with a processor through a cable; the fluorescence spectrophotometer sample table is connected with a sample cup through a guide pipe, activated sludge is arranged in the sample cup, and a peristaltic pump is arranged on the guide pipe; the activated sludge continuously flows through the fluorescence spectrophotometer sample table through the guide pipe for three-dimensional fluorescence detection through the peristaltic pump, sludge sedimentation in a traditional cuvette is avoided, measurement is simple and convenient, and on-line real-time monitoring of the activated sludge biomass can be achieved.

Image data analysis, and particularly identifying cluster or polony locations for performing base-calling in a digital image of a flow cell during DNA sequencing is described. A method may include generating a first plurality of flow cell images of a cellular sample immobilized on a support by conducting one or more cycles of sequencing reactions. The cellular sample may include a plurality of concatemer molecules therewithin. For the first plurality of flow cell image, pixel intensities, and a respective color purity of each of the pixel intensities may be determined. A base calling template may include base calling locations based on the pixel intensities and the respective color purity of the pixel intensities. The base calling template may be for registering a second plurality of flow cell images of the support in one or more subsequent cycles of the one or more cycles.

The invention belongs to the technical field of water environment detection, and particularly relates to a heavy metal concentration and water body flow velocity synchronous detection method for a dispersed drain outlet, which is used for synchronously detecting the heavy metal cadmium concentration and the water body flow velocity. The core of the method comprises a three-electrode sensing system consisting of a working electrode coated with a tungsten oxide film, a reference electrode and a counter electrode, and is assisted by an electrochemical workstation, a peristaltic pump, a flow cell and a signal processing module. The cadmium concentration is accurately measured through the square wave anodic stripping voltammetry, the flow velocity is synchronously detected through the open circuit potentiometry, dual-function detection is achieved through integration of the square wave anodic stripping voltammetry and the open circuit potentiometry, synchronous in-situ detection of the cadmium concentration and the water body flow velocity is achieved, and errors caused by measurement position differences are effectively eliminated. The result shows that the cadmium concentration and the dissolution peak current are in a linear relationship, and the water flow velocity logarithm and the open-circuit potential are in a linear relationship. The method designed by the invention is suitable for scattered and small sewage draining exit scenes, and effectively solves the problems of time consumption and equipment redundancy of traditional step-by-step detection. In an actual water sample test, the cadmium recovery rate is 80%-120%, the flow velocity measurement RSD is smaller than or equal to 5.0%, high reproducibility, stability and anti-interference performance are achieved, technical support is provided for real-time online evaluation of the total heavy metal emission amount, and the method has remarkable environmental monitoring application potential.

The present application relates to spectral technology, and specifically provides a nitrogen oxide analysis device and method, the analysis device comprising a first light source; further comprising: a flow cell having a main flow channel along its axial direction, an inlet being arranged adjacent to a first end of the flow cell, and an outlet being arranged adjacent to a second end; the first end, the inlet, the outlet and the second end are sequentially arranged in the axial direction of the flow cell; a first flow channel and a second flow channel are arranged in the body of the flow cell, and the gas sequentially passes through the inlet, the first flow channel and the second flow channel, enters the main flow channel and flows in the direction from the first end to the second end; a third flow channel and a fourth flow channel are arranged in the body of the flow cell, and the gas sequentially passes through the third flow channel, the fourth flow channel and the outlet in the second end; the flow directions of the gas in the third flow channel and the second flow channel are the same and opposite to the flow direction in the main flow channel. The present application has the advantages of accurate measurement results.

The present disclosure provides flow cell devices, systems, and methods for facilitating and performing DNA sequencing analysis with reduced system complexity and cost, significant cost of goods saving, and reduced contamination level. The sequencing systems described herein permit processing of multiple flow cells simultaneously, such that sequencing and imaging steps, or multiple sequencing methods, can be performed in parallel using a single sequencing system.

The invention relates to the technical field of environmental monitoring, and discloses a water quality monitoring device and method adapted to various environments, the device comprises an optical measurement unit, the optical measurement unit comprises a light source, a water sample flow cell and a spectrum detector, and two sides of the water sample flow cell are provided with at least one group of movable light windows and photoelectric positioning plates; the mechanical adjusting unit comprises a driving motor, a lead screw transmission mechanism driven by the driving motor, a light window support connected with the lead screw transmission mechanism and a position sensing module used for detecting the position of the movable support. The lead screw transmission mechanism comprises a lead screw and a movable sliding block arranged on the lead screw in a sleeving mode, and the movable sliding block is fixedly connected with the light window support. By automatically switching the optical path, the instrument can accurately measure low-concentration surface water and can also measure high-concentration sewage, so that the measuring range of single equipment is effectively expanded, and the accuracy of measured data in the whole measuring range is ensured.

Flow cell assemblies and related systems and methods are disclosed. In accordance with an implementation, an apparatus includes: a system, including: a receptacle; a cartridge assembly receivable within the receptacle. The cartridge assembly includes a well; and an outlet port fluidly coupled to the well. The apparatus includes a flow cell assembly, including: a body; a flow cell supported by the body and including a channel; and a sensor assembly comprising a heater and a thermal sensor. The outlet port is fluidly coupled to the flow cell. A leak test is to be performed on the cartridge assembly and the flow cell assembly using the thermal sensor.

In a method of preparing a flow cell, a slot die coater is used to introduce a nanoparticle suspension at a continuous flow rate to a substrate surface including depressions separated by interstitial regions, which generates a layer of the nanoparticle suspension at a stable concentration across the substrate surface. During the introduction of the nanoparticle suspension, at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions. An excess amount of the layer is removed from the interstitial regions.

The present application aims to provide an automatic analysis device that improves workability when moving in and out a flow cell. The automatic analysis device of the present application includes a photomultiplier tube, a substrate disposed vertically below the photomultiplier tube, and a flow cell disposed vertically below the substrate, the lower surface of the substrate having a convex portion and / or a concave portion, the upper surface of the flow cell having a concave portion and / or a convex portion, the automatic analysis device having a pressing member that presses the flow cell vertically from below to above in a state where the concave portion and / or the convex portion of the flow cell is fitted to the convex portion and / or the concave portion of the substrate.

The utility model discloses an optical path adjustable flow cell which comprises a flow cell cavity, two adjusting seats are oppositely arranged in the flow cell cavity, the two adjusting seats are both in threaded connection with the flow cell cavity, lenses are arranged at the opposite ends of the two adjusting seats, compression screws are arranged on the opposite sides, facing the flow cell cavity, of the lenses, and the compression screws are in threaded connection with the flow cell cavity. A connector is arranged at the tail end of the adjusting seat; the optical path adjusting device is simple in structure and reasonable in design, rotary fine adjustment of the optical path is achieved through threaded connection of the adjusting base and the flow cell cavity, the optical path can be adjusted without disassembling and assembling the flow cell, and convenience of experimental operation is improved. The lens and the cavity are directly matched and installed, the parallelism of the lens is ensured, and the detection precision is improved. In addition, a perfluoroether O-shaped sealing ring is adopted, so that the sealing performance is better, the corrosion resistance and the pressure resistance are stronger, and the stability and the reliability of equipment in a complex environment are ensured.

A fluid nanoparticle measuring device according to an exemplary embodiment of the present invention may include: a flow cell configured to allow flow of a liquid sample containing nanoparticles; a laser generating unit that irradiates the flow cell with a pulsed laser beam; a flow control unit that controls the flow of the liquid sample within the flow cell; and a signal detection unit that detects a signal from a plasma generated in the flow cell by the pulsed laser beam, wherein the signal detection unit includes a spectrometer that performs spectral analysis of the light signal from the plasma to obtain information about the nanoparticles.

The application discloses a light-proof flow cell and relates to the field of particle counter accessories, which comprises a first shell and a second shell, flow holes are formed in the first shell and the second shell, a wear-resistant light-blocking layer is arranged between the first shell and the second shell, a plurality of first plug-in holes are formed in the second shell, and a plurality of corresponding first plug-in columns are arranged in the plurality of first plug-in holes. The first shell and the second shell are made of quartz diamond material, and the hardness is high, so that the contact with the detection liquid is diamond material, the wear resistance can be improved, the first plug-in hole and the first plug-in column are arranged at four corners and are matched, and the butt joint precision is improved, so that the grinding effect of the flow holes by the grinding liquid can be effectively reduced, the phenomenon that the pore size of the flow cell becomes large can be avoided, and therefore the accuracy is not greatly affected during counting, and the stability during use and the counting accuracy are improved.

This invention discloses a gene sequencing pipetting assembly, including a pipetting module and a cleaning assembly. The pipetting module includes a reagent compartment for storing reagents, a reagent needle assembly for drawing or injecting reagents, and a pipetting drive assembly for driving the movement of the reagent needle assembly. The reagent needle assembly includes a reagent needle and a pipetting pump connected to the reagent needle. The reagent needle draws reagents from the reagent compartment and injects the reagents into a flow cell assembly under the action of the pipetting pump. The cleaning assembly includes a cleaning tank for storing cleaning solution, an inner wall cleaning unit for cleaning the inner wall of the reagent needle, and an outer wall cleaning unit for cleaning the outer wall of the reagent needle. This invention also proposes a gene sequencing system and a gene sequencing pipetting method. The gene sequencing pipetting assembly, pipetting method, and gene sequencing system of this invention utilize a reagent needle to transfer all reagents, which not only effectively simplifies the structure but also facilitates cleaning.

An analyzer is disclosed for detecting and quantifying a glutaraldehyde (GLUT) composition in a water sample. The analyzer includes a peristaltic pump and a three-way valve, where the pump draws in a water sample comprising a GLUT composition through the 3-way valve. The analyzer also includes a 6-way valve that receives the water sample and a bovine serum albumin-coated gold (Au-BSA) nanoclusters reagent. The analyzer also includes: a debubbler that receive a mixture of the water sample and the reagent and removes bubbles from the mixture; and a reaction coil that receives the water sample and the reagent from the debubbler, such that they are reacted. The analyzer further includes a fluorescence flow cell that receives the reacted mixture; measures a fluorescence intensity of the Au-BSA nanoclusters in the mixture; and determines a concentration of the GLUT composition in the water sample based on the fluorescence intensity.

This specification relates to an optical particle counter, a method for using an optical particle counter, and a method for reducing particle counting errors during use of an optical particle counter. The method includes placing an optical isolator between a laser and a flow cell to allow laser light to pass through the flow cell and to reduce the intensity of light returned to the laser as optical feedback that could cause mode hopping.

The invention discloses a novel chemical material liquid optical granularity instrument with an adjustable light path assembly, and relates to the technical field of liquid particle detection, the novel chemical material liquid optical granularity instrument comprises a machine shell and a light path adjusting assembly, a base is fixedly installed at the bottom end in the machine shell, and a pulse laser is fixedly installed on one side of the base; the light path adjusting assembly is arranged on the other side of the base and comprises a portal frame fixedly installed at the side end of the base. According to the liquid optical granularity instrument with the adjustable light path assembly for the new chemical material, scanning of a pulse laser spot in a two-dimensional plane is achieved by changing the deflection angle of a galvanometer, and then change of the focusing position of the spot is achieved by switching the working position of a field lens; the cleaning mode can be seamlessly switched in the operation gap of the detection mode, the surface of the optical window of the sample flow cell can be quickly and nondestructively cleaned by utilizing thermal stress generated by laser irradiation, the cleaning effect is good, and the cleaning speed is high.

Provided herein is a biological substance treatment method in which a flow cell is prepared, the flow cell including a chamber array device including a plurality of chambers and a cover body defining a flow path communicating with an opening of the plurality of chambers and provided in common for the plurality of chambers.

The utility model relates to the technical field of turbidity sensors, and provides a turbidity sensor calibration tool and a low-range turbidity sensor.The turbidity sensor calibration tool comprises a calibration barrel, a standard liquid bag and a hanging plate, the calibration barrel is suitable for being detachably connected with a detection module of the turbidity sensor, the standard liquid bag is communicated with the calibration barrel through a pipe body, and the hanging plate is arranged on the calibration barrel. The tube body is provided with an on-off unit used for controlling the on-off of a standard liquid flow path on the tube body, the hanging plate is provided with a first fixing position and a second fixing position, when the standard liquid bag is connected to the first fixing position, standard liquid in the standard liquid bag is suitable for flowing to the calibration barrel, and when the standard liquid bag is connected to the second fixing position, the standard liquid in the standard liquid bag is suitable for flowing to the calibration barrel. And the standard liquid in the calibration barrel is suitable for flowing to the standard liquid bag, so that the problems that the standard liquid is easy to splash and the operation is difficult due to the mode that the turbidity standard liquid is injected into the low-range turbidity sensor flow cell to calibrate the low-range turbidity sensor in the existing low-range turbidity sensor can be effectively solved.

In this information acquisition device and information acquisition method for measuring information about a specific substance that exists in a flow passage provided in a flow cell while allowing a fluid to flow through the flow passage, it is possible to measure said information while controlling the flow rate of the fluid in the flow passage. In the information acquisition device and the information acquisition method according to the present invention, a flow passage is formed in a flow cell by providing a cell section with a transparent member to block an opening of the cell section, and an adjustment unit is provided in the cell section. The adjustment unit changes the area of a cross section, of the flow passage, that is orthogonal to the flowing direction of the fluid, thereby controlling the flow rate of the fluid flowing through the flow passage of the flow cell.

The intermittent optical ion detection framework comprises a peristaltic pump, the peristaltic pump is communicated with a three-way electromagnetic valve I through an input pipe I, the three-way electromagnetic valve I is provided with a left port I, a middle port I and a right port I, the left port I is communicated with a liquid medicine tank I, and the right port I is communicated with a correction pipe; the peristaltic pump is communicated with a first quartz flow cell through a second input pipe, the first quartz flow cell is communicated with an ion detection sensor through a third input pipe, the ion detection sensor is communicated with a second quartz flow cell through a fourth input pipe, and the second quartz flow cell is communicated with a second three-way electromagnetic valve through a fifth input pipe. The second three-way electromagnetic valve is provided with a second left port, a second middle port and a second right port, the second left port is communicated with the second liquid medicine tank, the second right port is communicated with a third middle port of the third three-way electromagnetic valve, and the third three-way electromagnetic valve is provided with a third left port and a third right port. And the detection cost is reduced.

A photochemical reactor can include a plurality of flow cells whose illuminated internal surfaces coincide with a Φ = Φ * iso-flux boundary. Identical cells can be connected by short, small-diameter interconnects to form a cell chain of pitch p, and multiple chains can be arranged in parallel to meet throughput while maintaining residence-time and pressure-drop limits. Each cell can be illuminated by opposed, orthogonally oriented LEDs in 2-LED, 4-LED, or 6-LED topologies. In some embodiments, 6-LED illumination can be provided by a wireless cube LED apparatus having six emitters on orthogonal faces, a centrally located receiver coil, rectifier, and current driver. The cube can insert into keyed pockets that set optical standoff δ and orientation. A controller can sweep a transmitter frequency to select an operating frequency f_T* that maximizes received power for the installed receiver-coil geometry.

Embodiments of the present disclosure also relate to methods of fabricating flow cell substrates. Some exemplary workflows exploit orthogonal chemistries of substrate layers such that the process does not include polishing steps. Substrates prepared by the method described herein can include a first primer set and a second primer set compatible with simultaneous paired-end sequencing methods.

The invention discloses a pressure-resistant high-precision water quality low-turbidity measuring device, and belongs to the technical field of water quality turbidity measurement. And the pressure buffering mechanism is arranged on the mounting back plate. According to the pressure-resistant high-precision water quality low-turbidity measuring device, a measuring flow cell is formed through cooperation of the mounting back plate, the pressure buffering mechanism and the detection mechanism, the problem that stable measurement cannot be achieved under the condition of long-term water pressure and pump pressure tolerance is solved, and the pressure-resistant high-precision water quality low-turbidity measuring device is convenient to use through use of the pressure buffering mechanism. Pressure water flow firstly impacts a buffering conical panel in a first-stage buffering cavity, a conical inclined surface of the buffering conical panel can disperse impact force and preliminarily remove large impurities and bubbles, then a buffering spring and a damping rod act synergistically to absorb pressure fluctuation energy and ensure that the buffering process is stable, and the water flow enters a second-stage buffering cavity through a second separating and filtering buffering plate. Finer flow stabilization and bubble removal are carried out, and unstable pressure water flow can be converted into soft and stable water sample flow.

Flow cells and methods are described that enable control over DNA fragment length bias during amplification. One example flow cell includes a substrate and a polymeric hydrogel positioned over at least a portion of the substrate. A plurality of oligonucleotide primers may be attached to the polymeric hydrogel, wherein the plurality of oligonucleotide primers defines a density gradient across the substrate of the flow cell.

The utility model relates to an optical device which is used for carrying out ion chromatography detection on a sample and comprises a light source part which provides light with a preset wavelength range so as to form a first light beam propagating in a free space; and a flow cell provided with a guide channel, the guide channel containing the sample and provided with a first lens and a second lens, the first lens having a first clear aperture and the second lens having a second clear aperture; the ratio of the first clear aperture to the second clear aperture ranges from 1 to 3, and the ratio of the equivalent light spot size of the focusing part to the second clear aperture is not larger than 0.5, so that the ratio of the light intensity of the third light beam to the light intensity of the first light beam is not smaller than 62%. According to the device, efficient focused light beams are generated in the flow cell, and the intensity ratio of emergent light to incident light is increased, so that the light utilization efficiency is improved, and the sample detection sensitivity is improved. In addition, the utility model also relates to an analysis device.

A self-cleaning and base line stabilizing device of an automatic nutritive salt analyzer comprises a reaction assembly used for mixing a sample liquid sample, air and a corresponding reaction reagent to complete a chromogenic reaction; the light splitting detector is connected with the output end of the reaction assembly through a first connecting pipe; the cleaning assembly at least comprises a change-over valve, a second connecting pipe and a first peristaltic pump, the change-over valve is arranged on the first connecting pipe and located between the reaction assembly and the light splitting detector, one end of the second connecting pipe is connected with the change-over valve, the other end of the second connecting pipe can be connected with a reagent bottle filled with hydrochloric acid, and the second connecting pipe is sleeved with the first peristaltic pump. According to the method, pollution caused by adsorption of the flow cell can be actively prevented, the whole process only needs short time, baseline drift caused by adsorption of the chromogenic complex is prevented, the working efficiency is remarkably improved, and finally synchronous improvement of the determination efficiency and the data stability is achieved.

The application discloses a kind of air cooling island flow accelerated corrosion simulation test system and method, main loop subsystem, including high-purity water tank, main loop outlet pipe, electrode flow cell and main loop return pipe;The water outlet of high-purity water tank is connected with the one end of main loop outlet pipe, the other end of main loop outlet pipe is connected with the water inlet of electrode flow cell, the one end of main loop return pipe is connected with the water outlet of electrode flow cell, the other end of main loop return pipe is connected with the backwater of high-purity water tank;Dosing subsystem is used to add alkali agent or oxidizing agent to main loop outlet pipe;Flow accelerated corrosion test subsystem includes test electrode and corrosion tester;Test electrode is placed in electrode flow cell, and test electrode is connected with the input end of corrosion tester by wire;The material of test electrode is the same as the material of the equipment to be simulated air cooling island;The application realizes the real simulation of air cooling island equipment, meets the simulation of high flow rate and anaerobic condition, and the error of simulation test result is small.