The application provides a glycyrrhetinic acid composition with redness-reducing and anti-inflammatory functions, and a preparation method and application thereof, and belongs to the technical field of
cosmetics.
Glycyrrhiza is subjected to enzymolysis,
supercritical fluid extraction, and
precipitation to obtain glycyrrhetinic acid, the glycyrrhetinic acid is coupled with
allantoin to obtain a glycyrrhetinic acid-
allantoin conjugate, the glycyrrhetinic acid is reacted with
menthol to obtain glycyrrhetinic acid
menthol ester, the glycyrrhetinic acid-
allantoin conjugate,
phospholipid and
cholesterol are added into
ethanol for
dissolution,
ethanol is removed by rotary
evaporation under reduced pressure, a transparent film is obtained, an
ethanol solution is added, ultrasonic treatment is carried out, and micro-
porous membrane filtration is carried out to obtain the glycyrrhetinic acid composition with the redness-reducing and anti-inflammatory functions. The glycyrrhetinic acid composition with the redness-reducing and anti-inflammatory functions has the effects of redness reduction, anti-
allergy,
inflammation reduction,
antibiosis, soothing, moisturizing and the like, effectively improves the
transdermal penetration capacity of active ingredients, improves the water-
solubility, greatly improves the
bioavailability of the product, and thus expands the application range.