680 results about "Transplantation" patented technology

The invention provides an IBS micro-ecological transplantation intelligent prediction method and system based on multi-omics driving, and relates to the technical field of biomedicine. The method comprises the following steps: establishing a multi-omics data fusion subsystem to collect metagenome, metabolome, host genome and clinical phenotype group data of a target patient; inputting the data into a flora-metabolite combined network analysis model to construct an interaction network and extracting features; generating an incidence matrix based on the features and the host genome data and calculating indexes; generating indexes through a dynamic response algorithm in combination with the clinical phenotypic data and the indexes; and outputting a curative effect prediction result by using a transfer learning framework combined with modeling. The system comprises a data acquisition module, a network analysis module, a correlation calculation module, a dynamic response module and a joint modeling module. According to the method, multiple omics data are integrated, the flora and host relation is accurately mined, intelligent prediction of the micro-ecological transplantation curative effect is achieved, powerful support is provided for IBS personalized treatment, and meanwhile data processing and safety guarantee measures are taken.

The invention relates to the technical field of power transmission line monitoring, and discloses a power transmission line real-time monitoring method and platform. The method comprises the following steps: establishing a multi-omics data fusion subsystem to collect metagenome, metabolome, host genome and clinical phenotype group data of a target patient; inputting the data into a flora-metabolite combined network analysis model to construct an interaction network and extracting features; generating an incidence matrix based on the features and the host genome data and calculating indexes; generating indexes through a dynamic response algorithm in combination with the clinical phenotypic data and the indexes; and outputting a curative effect prediction result by using a transfer learning framework combined with modeling. The system comprises a data acquisition module, a network analysis module, a correlation calculation module, a dynamic response module and a joint modeling module. According to the method, multiple omics data are integrated, the flora and host relation is accurately mined, intelligent prediction of the micro-ecological transplantation curative effect is achieved, powerful support is provided for IBS personalized treatment, and meanwhile data processing and safety guarantee measures are taken.

The invention discloses a pharmaceutical composition for reversing pancreatic cancer gemcitabine drug resistance and application of the pharmaceutical composition, and belongs to the technical field of biological medicine. The composition comprises a generic FGFR inhibitor delatinib and gemcitabine, the concentration of the delatinib is 25 to 50 mg / kg, and the concentration of the gemcitabine is 20 to 30 mg / kg. By inhibiting an FGFR2 / FGFR3 signal channel and reducing the expression of FGFR protein in drug-resistant cells, the chemosensitivity of gemcitabine is synergistically enhanced, the apoptosis induction rate is increased by more than two times, and the synergic index (CI) is less than 1. In-vitro and nude mouse transplantation tumor experiments prove that the composition can significantly inhibit the proliferation of gemcitabine drug-resistant pancreatic cancer cells. The Gemcitabine drug-resistant pancreatic cancer drug can be used for preparing a drug for treating Gemcitabine drug-resistant pancreatic cancer with high FGFR3 expression, patients are screened through immunohistochemistry or gene sequencing, intravenous injection or oral administration is adopted, dosage forms comprise freeze-dried powder injection, capsules or tablets, and a new strategy is provided for pancreatic cancer drug-resistant treatment.

The discovery and application of immune checkpoint inhibitors (ICI) have significantly promoted cancer treatment. However, the response rate is still low in gastrointestinal (GI) cancers. To explore novel adjuvant treatment options, we performed fecal microbiota transplantation (FMT) of healthy donors on 10 GI cancer patients with resistance to anti-PD-(L) 1 treatment. The combination of FMT and anti-PD1 treatment was well tolerated and no serious adverse reaction was observed. Two out of 10 patients restored clinical responsiveness to anti-PD1 after FMT. Clinical benefits were shown to be associated with better colonization of co-occurred immunogenic microbes from donors, alongside activated immune status reflected by the peripheral immune cell population. Moreover, we identified microbial signatures of ICI responsiveness and validated in an independent cohort. Our study demonstrates the feasibility of FMT as a potential adjuvant therapy for ICI irresponsive GI cancer patients and laid a foundation for LBP / consortia development to enhance ICI efficacy.

The invention discloses a liver cancer image lightweight segmentation method based on UNet, and relates to the technical field of liver cancer segmentation of medical images. According to the method, a lightweight dilated convolution attention module combining local separable dilated convolution and a context anchor attention module is provided, and the feature expression ability is enhanced while the calculated amount is reduced; a self-adaptive wavelet pooling down-sampling module combining wavelet transform and a self-adaptive attention mechanism can perform further feature concentration and extraction on the feature map; a lightweight feature up-sampling and enhancement fusion module composed of a local separable cavity convolution module and a multi-frequency channel attention module can effectively improve the cross-scale feature fusion capability of the model, and maintain a low parameter amount and a low calculation amount. According to the method, while the parameter quantity and the calculation cost are remarkably reduced, the anatomical features of the liver can still be accurately captured, a finer segmentation result is provided, doctors are assisted in optimizing treatment schemes such as tumor excision and living body transplantation, and the clinical decision-making efficiency is improved.

The invention provides an LLM command line generation tool based on OpenHarmony and a transplantation method, belongs to the technical field of industrial Internet of Things, and aims to solve the problems that a traditional TypeScript / Node. Js scheme has limitation, is insufficient in local reasoning performance, safety performance and reliability and is high in deployment cost. The tool comprises an ETS development environment module, a code migration module, a dependency library adaptation module, a security enhancement module certificate and a deployment and operation module, a zero-dependency transplantation scheme is designed for special environments of unpacked management tools such as OpenHarmony, the problem of strong coupling of a traditional Node.js application to the environment during operation is solved, and the safety of the Node. Js application is improved. And the deployment threshold of the heterogeneous system is further reduced.

The invention discloses an intelligent hair follicle planting area measuring and calculating system based on microneedle densification, and relates to the technical field of scalp image processing. The intelligent hair follicle planting area measuring and calculating system based on microneedle encryption comprises a hair follicle center point registration module; an alopecia area measuring and calculating module; and a planting area measuring and calculating module. According to the method, center point mapping is carried out through the obtained scalp image of the target object, registration error analysis is carried out on the center point mapping process to judge whether center point positioning calibration and alopecia area measurement are carried out or not, then error analysis is carried out on the measurement process of the alopecia area, and the alopecia area measurement accuracy is improved. The method comprises the following steps of: firstly, determining whether to perform smooth intensity optimization and planting area measurement and calculation, and finally, performing error analysis on a measurement and calculation process of the planting area to determine whether to perform inter-frame displacement vector optimization, thereby being beneficial to ensuring the accuracy of hair follicle planting measurement and calculation in each link and improving the accuracy of hair follicle planting measurement and calculation. Therefore, the problem of deviation of the registration point during the measurement and calculation of the planting area in the micro-needle densification hair follicle planting process in the prior art is effectively solved.

The invention provides a tissue culture method and an acclimatization and transplantation method of coptis chinensis, and belongs to the technical field of plant tissue culture. The tissue culture method of the coptis chinensis comprises the following steps: (1) taking a tender shoot of a coptis chinensis rhizome as an explant, sterilizing, and inoculating into a basic culture medium for culturing, so as to obtain a coptis chinensis sterile seedling; (2) inoculating the aseptic seedlings of coptis chinensis into an adventitious bud differentiation culture medium for culture to obtain adventitious buds of coptis chinensis; (3) inoculating the coptis chinensis adventitious buds into a proliferation culture medium for culturing to obtain coptis chinensis proliferation seedlings; and (4) inoculating the coptis chinensis multiplication seedlings into a rooting culture medium for culture to obtain coptis chinensis test-tube seedlings. The tissue culture and acclimatization and transplantation method provided by the invention can improve the propagation efficiency of the coptis chinensis, remarkably shorten the growth cycle of the coptis chinensis, provide technical support for rapid propagation and sustainable utilization of resources of the coptis chinensis, and have wide application prospects.

The invention provides a pancreatic islet organ capable of efficiently maintaining pancreatic islet beta cell identity and a preparation method and application thereof. Specifically, the invention provides the preparation method for the in-vitro pancreatic islet organ, and the preparation method comprises the following steps: carrying out induced differentiation culture on the ZnT8-knocked-out pluripotent stem cells, so as to obtain the mature pancreatic islet organ. The invention also provides a corresponding transplantation composition and application thereof. The invention discloses that ZnT8 knockout is a key factor for effectively maintaining the identity stability of beta cells in pancreatic islet organs. In addition, the pancreas islet beta cell identity maintenance agent is combined with the ZnT8-knocked-out pancreas islet organ for use, so that the identity stability of the pancreas islet organ beta cell can be obviously maintained. The invention provides a new strategy for transplantation treatment of type 2 diabetes, and has excellent clinical transformation value.

The invention discloses a natural product-induced artificial nano-vesicle derived from human umbilical cord mesenchymal stem cells and application of the natural product-induced artificial nano-vesicle in ischemic diseases. The preparation method of the nano vesicle derived from the human umbilical cord mesenchymal stem cells comprises the following steps: S1, inoculating the human umbilical cord mesenchymal stem cells to a 3D microcarrier; then adding traditional Chinese medicine active ingredients to activate the human umbilical cord mesenchymal stem cells, continuing to culture, cracking the microcarrier, and harvesting cells; s2, dispersing the human umbilical cord mesenchymal stem cells obtained in S1 to obtain a suspension, extruding the suspension through a polycarbonate film, and then discarding large particles by adopting a gradient centrifugation method to obtain the nano-vesicles. Compared with naturally secreted exosomes, the exosome has the advantages that the yield is increased, the treatment efficiency is improved, the production cost is reduced, and compared with stem cells, the problems of low transplantation rate and the like are avoided. The stem cells are pretreated based on the traditional Chinese medicine, the vesicles are extracted by utilizing an extrusion method, and the yield and the treatment efficiency of the nano vesicles are remarkably improved.

Provided are TYK2 inhibitors of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. These compounds are useful, for example, in treating TYK2-mediated disorders, such as, autoimmune and inflammatory disorders, metabolic disorders, proliferative disorders, endocrine disorders, neurological disorders, allergic disorders, and disorders associated with transplantation.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in a humanized flora transplantation model.The application comprises the following steps that an experimental body is pretreated through sterile feeding or broad-spectrum antibiotics, then coprophilous fungus suspension of a functional dyspepsia patient is transplanted, and the humanized flora transplantation model is constructed; acquiring physiological data of the humanized flora transplantation model, and performing intervention on the traditional Chinese medicine composition after the humanized flora transplantation model is completed; acquiring physiological data of the traditional Chinese medicine composition intervened humanized flora transplantation model, and analyzing an evaluation result of the traditional Chinese medicine composition intervened humanized flora transplantation model by combining the evaluation parameters of the humanized flora transplantation model. The bottleneck that the traditional animal model is greatly different from the human microflora and the curative effect and the mechanism are difficult to transform is overcome, so that the research result is closer to the clinical practice, and the molecular mechanism of the traditional Chinese medicine composition is reliably revealed.

The invention relates to the technical field of medical information processing, in particular to a wound condition ultrasonic assessment method for free flap transplantation, which comprises the following steps: performing block processing on an acquired ultrasonic gray image to obtain each enhancement analysis candidate block, the block processing being beneficial to improving the contrast ratio of a fat area and an edema area; a plurality of enhanced analysis target blocks are screened through fat feature screening parameters, so that the image data analysis amount is reduced to a certain extent, and the wound condition ultrasonic evaluation efficiency is improved; a blood vessel ultrasonic frequency shift feature value and a fat echo factor are combined to determine a fat feature first evaluation value of an enhanced analysis target block, and then a fat feature second evaluation value of each gray level is determined, so that enhancement of fat discrimination under the condition that a probe is in poor contact with wound skin is facilitated; and an enhanced ultrasonic grayscale image which has a better enhancement effect and is used for ultrasonic evaluation of wound injury conditions is obtained.

Disclosed herein are dosage forms comprising a VAV1 degrader. More specifically, disclosed herein are dosage forms comprising 3-(2-chloro-4'-(2-oxopyridin-1(2H)-yl)-[1,1'- biphenyl]-3-yl)piperidine-2,6-dione or a pharmaceutically acceptable salt thereof. These dosage forms are useful, e.g., for treating a subject (e.g., a human subject) having a disorder or disease that can be treated by reducing the level of VAV1, for example an inflammatory or autoimmune disorder, a transplantation setting disorder, or a cancer.

The invention relates to the technical field of health management, and discloses a coronary artery bypass transplantation perioperative period cerebral apoplexy risk assessment method, which comprises the following steps: acquiring multiple groups of training physiological data, each group of training physiological data belonging to the same patient and including current physiological data and historical physiological data; based on the multiple groups of training physiological data, training a risk assessment model to obtain a target risk assessment model; for each to-be-evaluated patient, data extraction is carried out on original physiological data of the to-be-evaluated patient to obtain multiple pieces of physiological index data, and the original physiological data comprises current physiological data and historical physiological data; and performing evaluation based on the physiological index data by adopting the target risk evaluation model to obtain an evaluation result. By training the risk assessment model, cerebral apoplexy risk assessment can be accurately carried out, the scientificity and reliability of the assessment result are improved, medical intervention based on the assessment result is facilitated, support is provided for perioperative period management, and the risk of cerebral apoplexy in the perioperative period is reduced.

The invention relates to a biomarker for screening intestinal flora transplantation donors and application of the biomarker. The biomarker comprises intestinal flora and metabolites thereof, the intestinal flora comprises phylum firmicalis, bacteroides and the like, and the metabolites comprise short-chain fatty acid, tryptophan, indole, 5-hydroxytryptamine, lipopolysaccharide and the like. According to the method, the intestinal flora of different crowds is deeply analyzed, the relationship between each related index of the intestinal flora and the intestinal flora transplantation effect is studied, sufficient clinical verification is carried out, a biomarker for screening the intestinal flora transplantation donor is excavated, and a standard for judging whether the intestinal flora transplantation donor is qualified or not is established; and a new method and a new idea are provided for efficiently and accurately screening intestinal flora transplantation donors.

The gadolinium-based cationic polymer contrast agent is synthesized by chelating a cationic polymer and gadolinium ions, has high biological safety and can be used for cartilage imaging. The prepared contrast agent adopts an articular cavity direct injection method, so that the imaging effect is improved, and the contrast dosage is reduced. When the cartilage activity is normal, the content of glycosaminoglycan in the matrix is rich, and when the cartilage is inactivated or the activity is reduced, the content of glycosaminoglycan in the matrix is obviously reduced. The gadolinium-based cationic polymer contrast agent is combined with negatively charged glycosaminoglycan in a cartilage matrix through the charge effect. The gadolinium-based cationic polymer contrast agent can be used for noninvasive and quantitative evaluation of cartilage activity in nuclear magnetic resonance imaging, especially cartilage activity and stability in transplantation.

The invention relates to the technical field of bioinformatics, and discloses a three-generation full-length transcript sequencing data-based HLA (human leukocyte antigen) typing method, system, equipment and medium, by utilizing the technical advantage of long read length of a three-generation sequencing single molecule, a complete transcript sequence of an HLA gene is directly obtained, full-length HLA typing without PCR (polymerase chain reaction) amplification and short read length splicing is realized, and the method, the system and the equipment are simple and convenient to operate. The blank of the three-generation full-field transcript in the aspect of detecting the HLA typing is filled. The method effectively solves the problem that the cost, the efficiency and the accuracy are difficult to consider in the traditional HLA typing technology, not only avoids PCR amplification preference and short read length assembly errors and remarkably improves the typing accuracy, but also reduces the analysis complexity through an optimized bioinformatics process. According to the method, an efficient solution with economical efficiency and reliability can be provided for application scenes such as clinical transplantation matching and disease association research, and the method has important clinical application value and wide market prospects.

A microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix for liver regeneration and a preparation method. The hydrogel is prepared by means of combining fish liver decellularized extracellular matrix (dECM) and gelatin methacryloyl (GelMA), and loading induced pluripotent stem cell-derived hepatocytes (iPSC-heps) for liver regeneration. The microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix exhibits excellent biocompatibility, retains intact endogenous growth factors, maintains the biological activity of cells, ensures the effective encapsulation of the cells, and facilitates the robust functional expression of the iPSC-heps. After in-vivo transplantation, the survival rate and liver function of mice with acute liver failure are significantly improved, and liver regeneration and repair are promoted.

The invention discloses a ferromagnetic material defect identification method and system based on magnetic gradient tensor measurement, and relates to the technical field of nondestructive testing, and the method comprises the following steps: acquiring magnetic gradient tensor data of a to-be-tested piece; calculating a total horizontal derivative based on the magnetic gradient tensor data; calculating a z-direction partial derivative of each component based on the total horizontal derivative and calculating a vertical derivative based on the magnetic gradient tensor data; and identifying a defect boundary by using the magnetic gradient tensor fusion derivative detector and the magnetic gradient tensor anti-noise boundary detector, and outputting a defect profile diagram. According to the invention, the MGTFDED and MGTNRED detectors specially designed for industrial defect detection scenes are provided for the first time, and the problem that a geophysical method is not suitable for direct transplantation is solved. According to the method, the edges of various defects from surface cracks to deep buried holes and the like can be identified with high precision, and the accuracy, noise resistance and intelligent level of detection are remarkably improved.

The invention provides a software transplantation method based on a processor. The software transplantation method comprises the following steps: firstly, carrying out hardware type selection and instruction set compatibility analysis, analyzing a software binary code by utilizing a specific algorithm, counting and comparing instructions, and comprehensively evaluating hardware performance to determine adaptive hardware. Then, software transportability is evaluated, and a software dependency graph and a transplantation feasibility prediction model are constructed; then, an operating system is adapted, the loading sequence and parameters of a kernel module are dynamically adjusted, and setting of a basic input and output system is optimized; in a software transplantation implementation stage, source codes are analyzed and converted based on an abstract syntax tree, open source software adopts incremental compiling cache, binary software analyzes and processes compatibility problems, and meanwhile, a one-key installation program is optimized. And finally, performing server monomer testing and platform testing, monitoring performance, checking functions, analyzing faults and optimizing until the system meets requirements. According to the method, many key problems in the process of transplanting the software to the processor are effectively solved, and the success rate of transplanting and the stability of the system are improved.

The invention belongs to the technical field of medicine, and particularly relates to an excrement exosome, an excrement exosome transplanting method and application thereof, and the excrement exosome is prepared through the steps of excrement collection, excrement dilution, excrement oscillation and centrifugation, excrement supernatant filtration, excrement exosome extraction, excrement exosome purification and the like. The obtained excrement exosome is high in purity and small in particle size, impurities and pollutants can be effectively removed in the extraction and separation process, the bioavailability in vivo is high, and the excrement exosome can be absorbed by cells so that the biological activity of the excrement exosome can be exerted. By acting on a colitis mouse model, it is proved that the colitis disease index can be remarkably reduced, the barrier function can be enhanced, and intestinal inflammation can be inhibited through excrement exosome transplantation; the nerve injury of the Parkinson mouse can be obviously improved. Therefore, the excrement exosome has the prospect of being applied to preparation of drugs for relieving intestinal inflammation, enhancing the intestinal barrier function and relieving nerve injury, and a new thought and direction are provided for treatment of intestinal and nerve injury diseases.

The invention relates to application of a CSPR3 gene in promoting skeletal muscle regeneration. The invention provides a system of a transplantation material for promoting skeletal muscle injury repair and application of the system by utilizing a CSPR3 gene, and reveals that the CSRP3 gene participates in a repair process after skeletal muscle injury. The CSRP3 is knocked down in the skeletal muscle, so that the regeneration capacity of the muscle is destroyed; on the contrary, overexpression of the CSRP3 in the skeletal muscle accelerates the repair process of the skeletal muscle after injury. The skeletal muscle injury repair process can be obviously promoted through an allograft strategy, and the repair time is shortened. The invention provides a direction for promoting the development of a clinical treatment strategy for human skeletal muscle injury.

The invention relates to a flora transplantation clinical pathway standardization management method, device and equipment and a medium. The method comprises the following steps: on the basis of clinical data of a patient and screening data of a donor, executing flora suitability evaluation by using a deep learning model and selecting an adaptive donor; obtaining a flora sample of an adaptive donor, and carrying out high-throughput sequencing; generating a donor flora quality evaluation score according to a preset flora composition diversity index based on a sequencing result; screening the flora samples of which the quality evaluation scores are higher than a preset quality threshold value to prepare a flora preparation; detecting activity parameters and diversity parameters of the flora preparation, and performing colonization potential classification prediction by combining clinical data of the patient and adopting a support vector machine algorithm so as to output a potential colonization success rate; and when the potential colonization success rate exceeds a preset success rate threshold, outputting a clinical transplantation scheme through a preset transplantation scheme generation algorithm based on the flora preparation and the clinical data of the patient. According to the method, through multi-stage intelligent decision making, the safety and the effectiveness are improved.

The invention discloses a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. The invention belongs to the technical field of biological medicine, and relates to a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. According to the method, standard intestinal flora suspension is used as a functional raw material, poloxamer 407 and poloxamer 188 are used as matrixes, and some cryopreservation protective agents and other formulas are used as auxiliary materials, and the preparation method comprises the following steps: (1) preparing standard intestinal flora liquid; (2) gradually adding the following components according to the preparation concentration: 15%-22% of poloxamer 407, 0.5%-4% of poloxamer 188, 5%-20% of glycerol, 0.5%-1% of sodium carboxymethyl cellulose and the balance of 0.9% sodium chloride aqueous solution; (3) mixing and stirring the suspension intestinal bacterial liquid at room temperature, stirring the suspension intestinal bacterial liquid by a method of uniformly stirring the suspension intestinal bacterial liquid by an electric stirring blade until the suspension intestinal bacterial liquid does not have blocks and is uniformly dispersed, continuously stirring the suspension intestinal bacterial liquid until the liquid is viscous and uniform, and converting a viscous solution into a gel state at a corresponding temperature; and (4) sequentially putting the prepared intestinal flora gel preparation into freezing refrigerators at-20 DEG C and-80 DEG C for freezing and storing for later use. The preparation process is simple, the preparation is rapid, the auxiliary materials are medicinal and have good biocompatibility, and the activity of bacteria is not damaged.

Some embodiments relate to improved cryopreservative formulations and improved methods for cryopreserving and thawing cells. These formulations facilitate high density, low volume cell cryopreservation strategies which overcome the need for washing of cells post-thaw, and therefore result in greater cell recovery and viability. Pharmaceutical compositions comprising a cell population and a cryopreservative formulation as provided herein are also provided. Methods for treating a subject having a disease or condition that benefits from transplantation of a cryopreserved and thawed cell population are also provided.

The invention relates to a stem cell pretreatment technology in the field of biomedicine, which is characterized in that stem cells are pretreated in a specific parameter window (10-80mu g / mL, 5-60min and 36-38 DEG C) by establishing an ozone concentration-time-temperature cooperative control model, so that the anti-apoptosis ability, homing efficiency and paracrine function of the stem cells are remarkably enhanced. The method breaks through the technical bottleneck of low survival rate of traditional stem cell transplantation, and avoids the carcinogenic risk of gene modification. The application covers the three fields of myocardial repair, liver regeneration and nerve injury, and the special culture medium and the kit developed in a matched manner realize standardized operation. The survival rate of the pretreated stem cells after transplantation is increased by more than two times, the VEGF secretion amount is increased by 150%, and a safe and efficient new treatment strategy is provided for clinic.

This invention relates to the technical field of stem cell induction differentiation and transplantation therapy, specifically to a method for inducing human induced pluripotent stem cells to differentiate into dopaminergic neuronal progenitor cells, comprising the following steps: S1, human induced pluripotent stem cells are induced to differentiate into primitive neuroepithelial cells under the action of SB431542, DMH1, SHH, FGF8b, Purmorphamine, and CHIR99021; S3, intermediate primitive neuroepithelial cells are continuously induced to differentiate using BDNF, GDNF, AA, N2, B27 (without added vitamin A), cAMP, and GlutaMax to obtain dopaminergic neuronal progenitor cells. The dopaminergic neuronal progenitor cells obtained using the method provided by this invention can survive for a long time in the brain microenvironment of Parkinson's rats and have a significant repair effect on rat motor dysfunction.

Provided herein are tumor-antigen VGLL1 specific T cell receptors. The TCR may be utilized in various therapies, such as autologous cell transplantation, to treat a cancer. Methods for expanding a population of T cells that target VGLL1 are also provided.

The invention relates to a product for topical use in the treatment of skin affected by dysbiosis. The product has a pH ranging from 5.5 to 6.5 and essentially comprises water, glycerin and at least one crosslinked polyacrylate. This product can be used as a prerequisite for the transplantation of biological material favorable to the development of a healthy cutaneous bacterial flora.