32 results about "Autologous tissue" patented technology

The invention discloses a negative pressure interface material. The negative pressure interface material comprises a bioelastomer material and a biological material. The invention further discloses a preparation method of the negative-pressure interface material, rapid, continuous and large-size 3D printing of the bioelastomer material and the bioelastomer material composite material is realized by using a novel thermosetting material composite 3D printing technology and utilizing solvent compounding and solvent plastification. By utilizing the negative pressure interface material disclosed by the invention, new granulation tissues can rapidly grow by virtue of a biological scaffold under the action of negative pressure, regeneration of a new matrix is efficiently induced, wound surface defects are more rapidly filled, and optimized conditions are provided for later wound surface coverage; meanwhile, in the tissue remodeling stage, the material stent is gradually replaced by the autologous tissue through gradual degradation of the material, and finally the remodeling process is completed.

The present invention relates to a mould (1), the mould comprising a receptacle (10) and a lid (20) for forming a tissue graft, such as an autologous tissue graft for transplant and suturing. The mould is adapted to contain layers of biological material, providing pressure to the biological material and drain out excess fluid, thus providing a fast and effective means for building a tissue graft. The mould may comprise one or more resilient members, and at least one or more of the resilient members (RM) may be suitable to provide a specified force to apply the desired pressure to the tissue graft. The invention further relates to a method of using the mould.

The application discloses a plugging device and relates to the technical field of medical devices. The plugging device comprises a plugging body, an elastic connecting piece and a hanging component. The plugging body is adapted to the shape of a target plugging area. One end of the elastic connecting piece is arranged on the plugging body. One end of the hanging component is connected with the other end of the elastic connecting piece, and the hanging component is adapted to be hung on the tissue of the target plugging area. The plugging device for cauliflower-shaped left atrial appendages is made of degradable materials, can be implanted into the left atrial appendages of a patient through a minimally invasive catheter intervention operation to realize plugging of the left atrial appendages, can guide the climbing of the endothelial tissue in the left atrium, and can realize complete degradation of the device in the human body after endothelialization. Finally, the plugging effect is realized by the patient's autologous tissue, the formation and shedding of thrombus embolus in the left atrial appendages are effectively prevented, and the risk of stroke is greatly reduced.

A graft is provided that consists of a bioabsorbable network of polymer fibers that can rearrange upon dilation to provide an enlarged diameter and support a biological conduit. Additionally, a graft is provided in which the rearranged fiber network in the expanded state of the graft can act as a scaffold for cell infiltration and promote autologous tissue formation.

The invention provides an autologous tissue filler for static texture repair and a preparation method of the autologous tissue filler, and relates to the technical field of biological tissue filling. The filler provided by the invention comprises autologous blood cells, autologous hair follicle protrusion parts and hair follicle tissues homologous with the autologous hair follicle protrusion parts, wherein the hair follicle tissues are residual parts of autologous hair follicles after the protrusion parts are separated and surrounding tissues. The filler provided by the invention not only can effectively repair facial static lines and is compatible with dermis tissues of the static lines, but also cannot generate rejection reaction, and in addition, the filler can be regenerated and cannot be absorbed and shrunk, so that the filling effect can be effectively maintained.

The present invention relates to a mould (1) for forming a tissue graft, preferably an autologous tissue graft for transplantation and suturing. The mould comprises a receptacle (10) and a pressure plate (30). The mould is adapted to contain layers of biological material, providing pressure to the biological material and drain out excess fluid, thus providing a fast and effective means for building a tissue graft. The receptacle (30) is adapted with a mass m, the mass adjusted to provide the specific pressure, relative to the area of a bottom surface (11) of the receptacle, wherein the tissue graft is to be manufactured. In some embodiments, the mould may further be provided with a weighted element, the weighted element adapted with a mass correlating to an area of the receptacle, thus providing a specific amount of force and thus pressure to the biological material arranged in the mould during use.

The invention provides a breast augmentation method and method.The method comprises the steps that firstly, a shape memory biopolymer material with biological absorbability is selected, and a filling device with a preset three-dimensional configuration is formed through a weaving technology or a 3D printing technology; 2, the filling device is conveyed to the posterior gap of the breast through an endoscope channel or a conveying catheter or directly through a surgical incision and is released, and friction fixation with surrounding tissue is achieved through the radial supporting force of the filling device; 3, after the filling device is stably anchored in the posterior gap of the breast, attachment is completed by means of biocompatibility of the filling device, and surface autologous tissue growth is achieved. According to the method, the filling device is gradually degraded and absorbed by human tissues, only few polymer wire binding points are left finally, an autologous tissue filling structure is formed in the breast, the full, natural, lasting and stable breast augmentation effect is achieved, and the technical problems that autologous fat breast augmentation is easy to absorb, and a silica gel prosthesis is not natural in hand feeling are effectively solved.

Medical systems, devices and methods for creation of autologous tissue valves within a mammalian body are disclosed. One example of a device for creating a valve flap from a vessel wall includes an elongate tubular structure having a proximal portion and a distal portion and a longitudinal axis; a first lumen having a first exit port located on the distal portion of the elongate tubular structure; a second lumen having a second exit port located on the distal portion of the elongate tubular structure; a recessed distal surface on the distal portion of the elongate tubular structure, wherein the recessed distal surface is located distally to the first exit port; and an open trough on the recessed distal surface extending longitudinally from the first exit port.

A 3D printed degradable chest rib implant comprises a main body and a fixing port arranged on the main body, wherein the curvature of the main body is consistent with the curvature of a rib defect; the main body has a multi-layer structure, the inner layer is a mechanical support-bone fusion structure to provide initial strength required for maintaining the shape of the thoracic structure and respiratory expansion and space for growth of new bone tissue, and the outer layer is a porous structure to facilitate the growth of surrounding soft tissue and later biological fusion fixation; the fixing port on the main body is installed and fixed with a corresponding chest rib combination site; through the regulation of the degradable material components and macro-micro structure, the function of the degradable chest rib implant is programmed to realize the dynamic matching and transformation of mechanical stability and tissue regeneration, with the degradation of the degradable chest rib implant material, the autologous tissue gradually grows into and completely replaces the degradable chest rib implant; the present application can adapt to the repair requirements of congenital chest rib defects in children.

Disclosed herein are components, systems, and methods to collect tissue harvested from a patient during a surgical procedure and deliver the harvested tissue back into the patient's body without transferring the harvested tissue to a different tool or chamber between the collection and delivery. Specifically, embodiments of a tissue collection device are disclosed that include a housing, a scaffolding, and a plunger. The housing having lumen extending therethrough, the scaffolding positioned within the lumen, and the plunger positioned within and translatable with respect to a tubular body of the scaffolding. Also disclosed are methods of tissue collection using the tissue collection device and methods of assembly of the tissue collection device.

A filter assembly for a surgical suction system. The filter assembly has a containment defining a filter chamber an intake fitting on an upstream end of the chamber, an output fitting on an opposite downstream end of the chamber, and a filter element in the filter chamber and made at least partially of a bioresorbable bone substitute so that autologous tissue components carried in a fluid flowing from the fitting through the filter element in the filter chamber are trapped by the filter element.

The utility model discloses an autologous tissue stem cell in-vitro application constant-temperature device, which belongs to the technical field of stem cell preservation and comprises a constant-temperature box, a partition plate is fixedly mounted on the inner wall of the constant-temperature box, a first heat preservation plate is fixedly mounted on the upper surface of the partition plate, and a refrigerator and a storage battery are fixedly mounted on the inner bottom wall of the constant-temperature box respectively. The output end of the refrigerator fixedly communicates with a cold air conveying pipe, the top end of the cold air conveying pipe penetrates through the partition plate and the first heat preservation plate and extends to the position above the first heat preservation plate, and the refrigerator and the storage battery are installed on the inner bottom wall of the constant-temperature box, so that the storage battery can provide electric energy for operation of the refrigerator; cold air generated by the refrigerator can be continuously conveyed to the position above the partition plate through the cold air conveying pipe, and air outside the constant-temperature box can enter the position below the partition plate through the heat dissipation holes by forming a plurality of heat dissipation holes which are arranged at equal intervals in the left side face and the right side face of the constant-temperature box.

The degradable stent is of a hollow tubular structure with the two ends open and comprises a main tube body and retention flanges at the two ends of the main tube body, the main tube body comprises a plurality of coaxially-nested sub-tube bodies, annular gaps are formed between the adjacent sub-tube bodies, the two ends of any sub-tube body are connected with the retention flanges, and a plurality of holes are formed in the tube wall of each sub-tube body; and in the radial direction of the main pipe body, the porosity of the pipe wall of the sub pipe body is gradually increased from the central axis to the periphery. The main tube body is arranged to be a plurality of coaxially nested sub-tube bodies with gradually increased porosity, an outer-layer tissue migration guiding channel is formed, the sub-tube bodies on the outermost layer of the stent preferentially induce rapid migration and colonization of autologous tissues, and a gradual mechanical supporting environment is provided for deep tissue cell ingrowth along with the sequential reduction of the porosity of the inner layer. When autologous cells construct a complete cavity tissue structure, each layer of material of the stent is gradually degraded and absorbed according to a preset gradient, and finally a natural cavity with a physiological function is formed at an implantation part, so that the risk of a secondary operation is avoided.

Embodiments disclosed herein relate to devices and methods for autologous tissue transfer for a subject. In some embodiments, a syringe may include a barrel and an outlet as well as a primary plunger and a secondary plunger disposed at least partially within the barrel. The primary plunger may be transitioned between a closed configuration and an open configuration to permit fluid communication between a primary chamber and a secondary chamber located within the internal volume of the barrel. The user may employ the embodiments of such a device to extract adipose, or other desired, tissue from a subject into the primary chamber. In some embodiments, extracted adipose tissue may be separated into density-based layers of fat graft and waste products. The waste products may be isolated in the secondary chamber while retaining the fat graft in the primary chamber such that the fat graft may be re-administered to the subject.

The invention belongs to the field of intelligent medical treatment, and particularly relates to a system for treating SUI through transvaginal urethra middle section parapubis ligament linear suspension. The system comprises: a positioning dissection treatment unit 101, which is used for longitudinally cutting the vagina anterior wall mucous membrane along the median line of the vagina anterior wall to a set depth under the urethral transverse sulcus; the separation and exposure treatment unit 102 is used for separating the bladder from the vaginal wall, then separating the left / right gap of the bladder to obtain free fascia beside the middle section of the left / right urethra, and exposing the left / right pubis descending lateral ligament; and the suspension treatment unit 103 is used for respectively lifting fascia beside the middle section of the left / right urethra to a left / right pubis descending lateral ligament obliquely above the urethra for suturing and fixing. The inverted splayed linear seam of the fascia tissue beside the middle section of the urethra is hung to the ligament beside the pubis, meanwhile, the sutures on the two sides do not intersect at the middle line of the urethra, the included angle between the urethra and the bladder is recovered from the anatomy of the autologous tissue, the risks of mesh erosion, exposure and the like are avoided, and postoperative urethra obstruction and urinary retention are reduced.

The invention discloses a plugging device, and relates to the technical field of medical instruments. The plugging device comprises a plugging body, an elastic connecting piece and a hanging part, the plugging body is suitable for being matched with the shape of a target plugging area; one end of the elastic connecting piece is arranged on the plugging body; one end of the hanging part is connected with the other end of the elastic connecting piece, and the hanging part is suitable for being hung on the tissue of the target plugging area. The plugging device which is made of degradable materials and is made for the cauliflower-shaped left auricle can be implanted into the left auricle of a patient through minimally invasive catheter interventional operation to plug the left auricle, climbing and covering of endothelial tissue of a left atrium are guided, then complete degradation of an instrument in a human body after endothelialization is achieved, and the left auricle plugging effect is achieved. And finally, the plugging effect is completely realized by the autologous tissue of the patient, the formation and falling of thrombus emboli in the left atrial appendage are effectively prevented, and the occurrence risk of cerebral apoplexy diseases is greatly reduced.

The present invention relates to a human body-implantable structure for urethral compression and a composition for treating urinary incontinence comprising same. The structure of the present invention does not require a separate removal procedure due to the biocompatibility and biodegradability of a central main body implanted in the human body, can be replaced with autologous tissue without adhesion problems to thereby continuously compress the urethra, and has excellent durability without structural deformation even during thermal shrinkage of a shrinkable tube surrounding a connection portion between lifting threads, due to the heat resistance of a side mesh that connects the lifting threads and the central main body. In addition, the mesh included in the structure of the present invention is manufactured by weaving polymer yarns such that the course direction alternates front-to-back, thereby generating uniform resistance in all directions when inserted into the human body, which enables the structure to be smoothly inserted and be seated without curling in one direction.

The application belongs to the field of intelligent medical treatment and particularly relates to a system for treating SUI through transvaginal urethral middle segment pubic paravaginal ligament linear suspension. The system comprises: a positioning and dissection processing unit (101) for incising the mucosa of the anterior vaginal wall along the longitudinal line of the anterior vaginal wall to a set depth reaching the urethral transverse groove; a separation and exposure processing unit (102) for separating the bladder from the vaginal wall, then separating the left / right side space of the bladder to obtain the free left / right side urethral middle segment paravaginal fascia and expose the left / right side pubic ramus lateral ligament; and a suspension processing unit (103) for respectively lifting the left / right side urethral middle segment paravaginal fascia to the left / right side pubic ramus lateral ligament obliquely above and suturing and fixing. The application linearly sutures and suspends the urethral middle segment paravaginal fascia tissue in a reverse V shape on the pubic paravaginal ligament, and the sutures on the left and right sides do not cross at the urethral midline, which not only anatomically recovers the urethra and bladder angle with autologous tissue, avoids the risk of mesh erosion and exposure, but also reduces the incidence of postoperative urethral obstruction and urinary retention.

The invention discloses a method for preparing a wound dressing from human hair, which comprises the following steps: firstly, carrying out hydrophilic modification on the human hair to enable the human hair to easily absorb water and be easily biodegraded, then pouring the human hair into a mold for drying or freeze-drying to obtain a membrane or porous sponge with a required shape and size, and finally, preparing nano-silver particles by adopting an in-situ method in an adhesion manner. The prepared wound dressing is good in biocompatibility, capable of stopping bleeding quickly and antibacterial. The human hair keratin is free of immunogenicity, rich in raw material source, low in cost, capable of being industrially produced and applied on a large scale, good in cell compatibility and capable of stopping bleeding, and a method for preparing nano-silver in situ through an adhesion method is simple. By means of the method, an ideal wound dressing can be obtained. The human hair keratin porous sponge and film prepared by the method provided by the invention adsorb wound blood through the porous structure to form a blood coagulation net rack, can quickly stop bleeding, has the characteristics of no antigenicity, good biocompatibility, degradability, stimulation of cell division and promotion of healing, and belongs to the porous sponge and film which can be implanted into a human body and can be used for quickly stopping bleeding. The biological scaffold material has the advantages of good biocompatibility, good histocompatibility, capability of inducing the formation of autologous tissues, and capability of being degraded and absorbed in the body, and has obvious progress compared with the existing medical material.

The invention discloses a bionic rhinoplasty stent, and relates to the technical field of rhinoplasty, the rhinoplasty stent comprises a nasal columella area and a nasal septum clamping area connected with the nasal columella area, and the nasal columella area is located in front of the nasal septum clamping area; the columella nasi area comprises a columella nasi main body, the left side and the right side of the columella nasi main body are both connected with outer side foot supporting parts, the columella nasi main body and the outer side foot supporting parts are of an integrated structure, and the nasal septum clamping area comprises two nasal septum clamping pieces connected with the columella nasi main body; the nasal columella main body and the outer side foot supporting part are integrally arranged, so that the rhinoplasty stent does not need to be set up and sutured, an autologous tissue does not need to be additionally used for nose tip heightening, suturing and fixing, the stent can be directly adopted, the rhinoplasty difficulty is reduced, the time needed by rhinoplasty is shortened, and the rhinoplasty efficiency is improved. The problems that due to the fact that the outer side foot support and the fornix supporting portion support are sutured respectively, the nose tip portion is loosened and displaced, the nose tip rotates up and down, and the beauty seeker needs to be operated again are solved, and the pain of the beauty seeker in the rhinoplasty operation is relieved.

Disclosed in the present invention is a bionic rhinoplasty stent, relating to the technical field of rhinoplasties. The rhinoplasty stent comprises a nasal columella area and a nasal septum clamping area connected to the nasal columella area. The nasal columella area is located in front of the nasal septum clamping area. The nasal columella area comprises a nasal columella body. The left and right sides of the nasal columella body are connected to outer side foot supporting parts. The nasal columella body and the outer side foot supporting parts are of an integrated structure. The nasal septum clamping area comprises two nasal septum clamping pieces connected to the nasal columella body. According to the present invention, the nasal columella body and the outer side foot supporting parts are integrally arranged, and without construction and suturing of the rhinoplasty stent, and without additional autologous tissue for elevating and suture fixing of the nasal tip, the stent of the present application can be directly adopted, thus reducing the difficulty of the rhinoplasty, shortening the time required by the rhinoplasty, and avoiding the problem of the need for another surgery for those who seek beauty due to loosening and displacement of the nasal lobule, or upward / downward rotation of the nasal tip caused by separate suturing of an outer side foot stent and a dome supporting part stent. Therefore, the pain of those who seek beauty during rhinoplasty is reduced.

The invention belongs to the technical field of far-infrared active cotton, and particularly relates to element-energy reinforced far-infrared refined molecular active cotton which is prepared from 100 parts of element-energy far-infrared mineral powder and 200-900 parts of polyurethane foaming raw materials, the element-energy far-infrared mineral powder comprises 30-40 parts of aluminum oxide, 25-35 parts of zinc oxide, 10-20 parts of silicon oxide and 4.0-8.0 parts of titanium oxide, and the element-energy far-infrared mineral powder is prepared from 100 parts of element-energy far-infrared mineral powder and 200-900 parts of polyurethane foaming raw materials. 10 to 14 parts of zirconium oxide and 1.5 to 2.5 parts of platinum. The technical problems that existing far infrared cotton obviously releases negative ions, contains high harmful radiation, is weak in far infrared energy and poor in application effect are solved, the active cotton has the advantages of being wide in emitted far infrared ray amplitude, high in strength and good in durability, blood circulation can be effectively improved, the whole tissue cell activity can be activated, and the health care effect is achieved. The repairing capability of autologous tissues is enhanced, and the problems of sleep obstruction and related soreness can be improved.

The application discloses a self-adapting valve skirt and a preparation method thereof, and particularly relates to the technical field of valves. The self-adapting valve skirt comprises an upper semi-permeable membrane, a lower semi-permeable membrane, a water-soluble adhesive and inorganic salt; the upper semi-permeable membrane and the lower semi-permeable membrane are sealed to form a membrane bag for embedding the water-soluble adhesive and the inorganic salt; and the outer sides of the upper semi-permeable membrane and the lower semi-permeable membrane are coated with a degradable coating layer for sealing pores. The self-adapting valve skirt has the self-adapting property of liquid, can well fill the gap between the valve and autologous tissue, and the free flow of liquid will not generate pressure on the contacted part, thereby affecting the conduction block.

A system and method for harvesting autologous tissue, mincing it into fragments that are visible and measurable when filtered, and delivering a portion of the tissue back into the patient without the need to directly touch the tissue. During the same surgical procedure, the tissue can be mixed with a biocompatible agent before introduction into the repair site.

The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted and restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall. In the third state, the second clamping member protrudes from the first clamping member and extends in a circumferential direction of the frame body and abuts against an outer surface of the frame body, so that an autologous valve leaflet and adjacent tissues are capable of being clamped between the second clamping member, the first clamping member, and the frame body. The contact area between the valve prosthesis and the autologous tissues can be increased, the position stability of the valve prosthesis in the heart can be improved, and the success rate of the operation can be increased.

The application discloses a breast surgery porous silicon hydrogel breast filling prosthesis capable of being organized and fused and a preparation method thereof, and relates to the field of plastic technology. The prosthesis body is integrally formed by a medical-grade biocompatible silicon hydrogel, and has a three-dimensional through porous network structure. The pores penetrate through the surface layer and the internal matrix of the prosthesis and are interconnected. The effective pore size is 80-300 microns, and the porosity is 40%-65%. The inner wall of the pores is provided with a nanoscale rough micro-morphology and a biological active factor grafting layer. The application provides a physical channel for the infiltration and growth of autologous soft tissue and capillary blood vessels through the global through porous structure. In combination with the physicochemical synergistic induction effect of the biological active micro-environment of the pore wall, the prosthesis and the autologous tissue of the breast are deeply biologically fused, the thickening and contraction of the fibrous envelope are inhibited, the implanted position of the prosthesis is effectively fixed, and the risk of displacement of the prosthesis is reduced.

Disclosed herein are components, systems, and methods to collect tissue harvested from a patient during a surgical procedure and deliver the harvested tissue back into the patient's body without transferring the harvested tissue to a different tool or chamber between the collection and delivery. Specifically, embodiments of a tissue collection device are disclosed that include a housing, a scaffolding, and a plunger. The housing having lumen extending therethrough, the scaffolding positioned within the lumen, and the plunger positioned within and translatable with respect to a tubular body of the scaffolding. Also disclosed are methods of tissue collection using the tissue collection device and methods of assembly of the tissue collection device.

The present invention relates to an insertable structure for urethral compression in the human body, and a urinary incontinence treatment composition including same. The present invention enables accurate application of a desired amount of pressure to the urethra only by a simple procedure of adjusting, with the naked eye, the lengths of central thickness adjustable labels which are located at both ends of a belt shaped band and externally exposed from the body, the band being inserted into the body in order to apply an appropriate stepwise pressure to the urethra according to the alleviation of urinary incontinence symptoms. Accordingly, the structure of the present invention enables the pressure applied to the urethra to be varied according to a change in a symptom only with a single insertion into the body, and due to the high biocompatibility and biodegradability thereof, requires no separate removal procedure and is replaced by autologous tissue without adhesion issues, thereby continuously applying pressure to the urethra.

The invention relates to the field of biological medicine, and discloses a tumor organ-immune cell co-culture method and application. The method comprises the following steps: digesting and counting organoid; performing T cell amplification; counting T cells; calculating the volume of a cell suspension; and co-culturing. According to the application, through co-culture of the organoid and the T cells, the sensitivity of different medication schemes is detected by utilizing flow cytometry, and the lethality of different drugs to the organoid is detected, so that the sensitivity of autologous tissues of a patient to the medication schemes is reflected.

The invention discloses a shaping method for filling depressed static lines with an autologous gel-state extract, and particularly relates to the technical field of medical cosmetology. The reshaping method comprises the following steps: cutting a small opening at one end of a wrinkle at a sunken part of skin, then putting a gel-state substance containing receptor venous blood into a subcutaneous gap of the opening, then taking the receptor venous blood again for extraction, injecting the obtained liquid extraction product into the gel-state substance containing the receptor venous blood, and finally performing reshaping on the gel-state substance containing the receptor venous blood to obtain the reshaping product containing the receptor venous blood. And after the volume is expanded until the concave part is raised, finishing the shaping of the concave static lines. According to the invention, the autologous tissue is used as a filler, so that no rejection reaction occurs in the subsequent treatment process; blood of a receptor is used as a raw material, so that the problem of vascular embolism is avoided, and serious negative effects such as skin necrosis and blinding are avoided; in addition, the reshaping method studied by the invention does not have the flow problem after filling the subcutaneous space, and the reshaping method is safer and more reliable.