The invention discloses a material increase manufacturing method of a multi-scale biomimetic artificial bone support. The material increase manufacturing method comprises blending a biopolymer material and a bioceramic material, blending the mixture and deionized water or an organic solvent to obtain uniform slurry, carrying out freeze drying to obtain uniform powder, blending the uniform powder and deionized water or an organic solvent, carrying out vacuum exhaust, carrying out quantitative extrusion by a screw pump, by a XYZ motion device, designing internal aperture shapes, sizes and porosity of a geometric model by computer program according to a bone defect 3D geometric model obtained by CT scanning, and carrying out material increase manufacture under control of an extruded material motion locus. Through use of a degradable biological compound material, human autologous tissue finally replaces bone defect positions so that human lifelong growth requirements are satisfied. The needed biomaterial is quantificationally extruded by the screw pump so that use amount can be accurately controlled and an artificial bone clinical application cost is substantially reduced. The material increase manufacturing method has the advantages of accurate printing material use amount, wide material application range, accurate and controllable aperture structure, and free formation of a macroscopic geometric shape.