11 results about "Tissue sealant" patented technology

The invention discloses a high-performance tissue sealant as well as a preparation method and application thereof, and relates to the technical field of medical materials. The tissue sealant is prepared from the following raw materials: amino-containing protein, a multi-arm polyethylene glycol derivative and an optional multi-amino polymer, wherein the amino-containing protein comprises at least one of lactoferrin, phycocyanin, whey protein, beta-lactoglobulin, cytochrome C, recombinant collagen, recombinant fibronectin and alpha-lactalbumin. The sealant provided by the invention has the characteristics of rapid gelling, strong adhesion, high mechanical strength, low swelling, antibacterial property and the like, can realize efficient tissue wound sealing, hemostasis and repair in a wet complex environment, is simple and convenient to prepare, safe in material source and good in biocompatibility, is suitable for being used in various wound scenes, and has wide application prospects. Good application prospects are realized.

The present specification describes a biocompatible hemostatic composition and a biocompatible tissue sealant, which when used in combination provides a safe and effective method of achieving hemostasis. The biocompatible composition and sealant may be applied either on a surface of the patient's body, or inside the body cavity. The combination may be used to control bleeding from external wounds and internal injuries, as well as to minimize bleeding during surgical procedures.

Compositions and methods related to hydrogel tissue sealants are generally described. In certain embodiments, a hydrogel forming composition is provided in dry form (e.g., as one or more powder mixtures) and comprises at least an electrophilic polymer crosslinking agent and a nucleophilic polymer such as a protein that is capable of crosslinking with the crosslinking agent. One or more solvents able to dissolve the crosslinking agent and the protein can be provided and used to dissolve the hydrogel forming composition to facilitate crosslinking.

The application discloses a medical tissue sealant with biological activity and a preparation method and application thereof, and relates to the field of biomedical technology. The preparation raw material of the medical tissue sealant comprises component A and component B, wherein the component A comprises a polyethylene glycol derivative; and the component B comprises a blood product, and the blood product comprises a blood component and an anticoagulant. The medical tissue sealant can efficiently retain the biological active components inherent in the blood product, such as platelet-derived growth factor and fibrinogen, has the advantages of short gelation time (3-30 seconds), excellent mechanical properties (the compression strength is higher than 800 kPa, the shear strength is higher than 100 kPa, and the anti-burst pressure is higher than 700 mmHg), and moderate degradation time (which can be regulated within 15-30 days), and has a good application prospect in the fields of wound plugging, hemostasis and wound repair.

A method of promoting healing of a wound generally includes administering to the wound an amount of a PEP exosome preparation effective to promote healing of the wound. In one or more embodiments, the PEP exosome preparation includes a tissue sealant or surgical glue. In one or more embodiments, the wound is an ischemic wound, a puncture wound, a laceration, an abrasion, a surgical wound, a skin graft, or a traumatic wound.

The invention discloses a bioactive medical tissue sealant as well as a preparation method and application thereof. Specifically, the medical tissue sealant is prepared from the following raw materials: a polyethylene glycol derivative and a blood product, the blood product contains a blood component and an anticoagulant, the blood component is human or animal blood or powder prepared from the blood, and the molecular weight range of the polyethylene glycol derivative is 2-100 kDa. The tissue sealant prepared by the invention has high-strength mechanical support (the compression strength is greater than or equal to 20 MPa) and lasting interface adhesive force (the shear strength is greater than or equal to 90 kPa), and not only can adapt to the change of dynamic wound mechanical stress, but also can realize controllable release of bioactive components; the method has wide application prospects in the clinical fields of hemostasis, wound repair, tissue regeneration, chronic wound treatment and the like.

The invention belongs to the technical field of biomedical materials, and discloses preparation of a low-swelling medical tissue sealant and application of the low-swelling medical tissue sealant in dura mater repair. The invention discloses a sealant. The sealant is prepared from the following raw materials: multi-arm polyethylene glycol active ester and aminated gelatin. The invention provides a sealant. The sealant is formed by crosslinking multi-arm polyethylene glycol active ester and aminated gelatin through amido bonds. The sealant has the advantages of rapid gelling, high mechanical strength, strong tissue adhesion, ultralow swelling ratio, controllable degradation and excellent biocompatibility. The sealant can realize in-situ sealing and repairing of dura mater injury and prevent leakage of cerebrospinal fluid, has antibacterial, anti-infection and nerve protection effects, is suitable for repairing of dura mater and dura mater, and is especially suitable for minimally invasive neurosurgery.

This invention discloses a method for synthesizing polyethylene glycol (PEG) carboxyl-activated esters. This preparation method utilizes centrifugation, taking advantage of the density difference in the solvent to accelerate the extraction process, thus saving production time. Furthermore, purification via membrane treatment in hydrochloric acid solution improves product purity. The use of hydrochloric acid prevents the degradation of the carboxyl-activated ester in water, while the membrane treatment rapidly removes insoluble substances, ensuring purity while preventing deactivation of the carboxyl-activated ester. Both methods employed are highly adaptable to industrial applications. The re-optimized synthesis and purification steps significantly improve the purity and yield of the PEG carboxyl-activated ester. This method for preparing PEG carboxyl-activated esters is simple, yields high purity and high output, and is easily industrialized. It can be used for drug modification, hydrogel preparation, medical sponges, tissue sealants, bio-adhesives, biological scaffolds, fluorescence imaging, and more.

The invention provides injectable, tough hydrogels that can be crosslinked in situ on demand using minimally-invasive methods, such as visible light exposure is an unmet medical challenge. Among the emerging biopolymers for tissue sealing, gelatin methacryloyl (GelMA), a naturally-derived biopolymer obtained from denatured collagen, has secured a promising role as a result of its excellent bioadhesion, biodegradation, and biocompatibility. To overcome one of the main shortcomings of GelMA, i.e., brittleness, we hybridized it using methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid GelMA-AlgMA hydrogels provide a photocrosslinkable, injectable, and adhesive platform with an excellent toughness that can be engineered using divalent cations, such as calcium. This class of novel hybrid biopolymers with more than 600% improved toughness may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants in minimally invasive procedure, especially for stretchable tissues.

The present application belongs to the field of medical materials, and relates to an injectable retinal sealant and a preparation method, which comprises degradable adhesive powder and hydrophobic medium silicone oil, and the degradable adhesive powder and the hydrophobic medium are uniformly mixed in a certain proportion; the degradable adhesive powder is prepared into a gel by reacting modified hyaluronic acid with gelatin to form stable amide bonds, and then freeze-dried and ground into dry powder. In the treatment operation of a hole source retinal hole, the sealant is directly delivered to the retinal hole, and can be effectively adhered and simultaneously blocked by slight pressing, and the tissue sealant can be used underwater, so that the vitreous body does not need to be cut. The retinal sealant has low production cost, and has strong underwater tissue adhesion performance and excellent biocompatibility.

The invention relates to a photosensitive tissue sealant and a preparation method thereof. A network of the photosensitive tissue sealant is formed by interweaving CSLA, CSNB and a bridging agent polyethylene glycol derivative; under the irradiation of ultraviolet light, disulfide bonds on CSLA molecules are reversibly broken and reconstructed, so that the gel is endowed with strong adhesive capacity and toughness; under the irradiation of ultraviolet light, an o-nitrobenzene group on the CSNB molecule is converted into o-nitrosobenzaldehyde, the o-nitrosobenzaldehyde reacts with amino to form a C = N bond, and an S-N bond and a C-N bond are formed between the CSLA molecule and the CSNB molecule; the above reactions are the key to realize high adhesion and high crosslinking density of the photosensitive tissue sealing glue. The invention also relates to application of the photosensitive tissue sealing glue in preparation of biological glue, experiments prove that the photosensitive tissue sealing glue has good biocompatibility, short gel forming time, tissue adhesion strength of 86.5 kPa and bursting pressure of 667 mmHg, animal experiments prove that the photosensitive tissue sealing glue has excellent tissue sealing and hemostasis effects in large and small body bleeding scenes, and the photosensitive tissue sealing glue has good application prospects. The method is suitable for high-pressure bleeding on complex sites and has wide application prospects.