2 results about "Tissue sealant" patented technology

This invention discloses a method for synthesizing polyethylene glycol (PEG) carboxyl-activated esters. This preparation method utilizes centrifugation, taking advantage of the density difference in the solvent to accelerate the extraction process, thus saving production time. Furthermore, purification via membrane treatment in hydrochloric acid solution improves product purity. The use of hydrochloric acid prevents the degradation of the carboxyl-activated ester in water, while the membrane treatment rapidly removes insoluble substances, ensuring purity while preventing deactivation of the carboxyl-activated ester. Both methods employed are highly adaptable to industrial applications. The re-optimized synthesis and purification steps significantly improve the purity and yield of the PEG carboxyl-activated ester. This method for preparing PEG carboxyl-activated esters is simple, yields high purity and high output, and is easily industrialized. It can be used for drug modification, hydrogel preparation, medical sponges, tissue sealants, bio-adhesives, biological scaffolds, fluorescence imaging, and more.

The present application belongs to the field of medical materials, and relates to an injectable retinal sealant and a preparation method, which comprises degradable adhesive powder and hydrophobic medium silicone oil, and the degradable adhesive powder and the hydrophobic medium are uniformly mixed in a certain proportion; the degradable adhesive powder is prepared into a gel by reacting modified hyaluronic acid with gelatin to form stable amide bonds, and then freeze-dried and ground into dry powder. In the treatment operation of a hole source retinal hole, the sealant is directly delivered to the retinal hole, and can be effectively adhered and simultaneously blocked by slight pressing, and the tissue sealant can be used underwater, so that the vitreous body does not need to be cut. The retinal sealant has low production cost, and has strong underwater tissue adhesion performance and excellent biocompatibility.