296 results about "Biological fluid" patented technology

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

The invention provides a light-excited lateral flow immunosensor reagent strip, a detection analysis method and application of the light-excited lateral flow immunosensor reagent strip. The reagent strip comprises an electrode substrate, a combination pad, a sample pad layer, a chromatography membrane and a water absorption pad, and the sample pad layer, the combination pad, the chromatography membrane and the water absorption pad of the reagent strip are connected end to end and are sequentially overlapped and pasted on the electrode substrate. The light-excited lateral flow immunosensor reagent strip is applied to quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid or urine.

Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.

Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and / or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.

Apparatus and associated methods relate to lyophilizing a solid phase composition (SPC). In an illustrative example, the SPC is received in a frozen state in a first packaging. The SPC may be, for example, transferred into a second packaging having a thermally conductive layer, mechanically distributed to a predetermined maximum thickness to form a block having at least one homogenous dimension, and provided with a heat source configured to communicate substantially all thermal energy to the SPC via the thermally conductive second layer. In some embodiments, the SPC may be maintained in the frozen state. For example, the lyophilized SPC may be transferred to a third packaging. Various embodiments may limit physical contacts with the SPC to the first packaging, the second packaging, and the third packaging. Various embodiments may advantageously maintain sanitation, retain nutrients of the SPC, and / or promote consistent results from the lyophilization process.

A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

Assays for detecting the level of soluble UNC5C in a biological fluid sample from a patient, and the use of such levels as markers of neurodegenerative disease presence and / or severity are described. Antibodies and fragments thereof capable of binding to UNC5C, and the use of such antibodies for detecting the level of soluble UNC5C in a biological fluid sample from a patient are also described, as well as methods for detecting the level of soluble UNC5C in a biological fluid sample from a patient using anti-UNC5C antibodies in a clinical context.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

The application relates to the technical field of free radical detection, in particular to a high-sensitivity in-situ capture and detection method of organic free radicals based on a DIPPMPO probe and application, and the method comprises the following steps: adding a chemical probe DIPPMPO into a reaction system containing potential organic free radical precursors, so that the DIPPMPO and organic free radicals generated in a reaction process occur adduct reaction to form a DIPPMPO-free radical adduct which can be detected under liquid chromatography-mass spectrometry conditions; performing high performance liquid chromatography-quadrupole-time of flight mass spectrometry analysis on a mixed solution after the adduct reaction is completed, so that first mass spectrometry data and secondary mass spectrometry fragment information of the DIPPMPO-free radical adduct are obtained; and automatically processing the secondary mass spectrometry data, screening out parent ions with continuous neutral loss as potential DIPPMPO-free radical adduct candidate signals. The application does not need derivatization, is simple to operate, is broad-spectrum and high-efficiency, and can be applied to environmental water samples, biological fluids, chemical reaction liquids or drug metabolism systems.

A method for activating a physiological signal sensing device through a handheld device to measure a physiological signal of an analyte in biological fluids is provided. The physiological signal sensing device includes a transmitter including a power unit, a switch unit, a magnetic field sensing unit and a processing unit. The method includes: establishing an inductive magnetic field between the handheld device and the transmitter, causing the magnetic field sensing unit to generate an inductive signal; in a first operating cycle, activating the switch unit by the inductive signal, causing the power unit to connect to the processing unit to activate the processing unit; providing an activation signal by the processing unit to turn on the switch unit; causing the switch unit to enter a self-maintaining state; and in a second operating cycle, connecting the power unit to the processing unit through the switch unit in the self-maintaining state.

Soluble gp120 (sgp120) is associated to HIV-1-induced immune dysfunction, such as chronic immune activation. However, the detection of sgp120 in biological fluids such as plasma, serum, cervicovaginal fluids, and cerebrospinal fluids is challenging. The present application relates to novel methods and kits for the detection of sgp120 in biological fluids. These methods and kits are based on the use of specific combinations of sgp120-binding molecules recognizing particular domains of sgp120, notably the N-terminal 8-stranded β-sandwich structure, the constant region 1 and 2 (C1-C2) portion, the bridging sheet of the Co-Receptor Binding Site (CoRBS), and / or the CD4-binding domain.

The present disclosure provides materials and methods related to the purification of a biologic from a biological fluid. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.

The invention discloses an exosome extraction device and method, and belongs to the technical field of exosome extraction.The exosome extraction device is provided with a rotating motor, an extraction barrel, a mounting pipe, an electric push rod, a rotating top strip, a cleaning scraper and a filter plate, and the rotating top strip rotates between a first rotating seat and a second rotating seat which correspond to each other; meanwhile, a top strip is rotated to jack up a connecting plate to be away from a mounting pipe until a cleaning scraping plate is tightly attached to the inner wall of the extraction barrel and a filter plate, the electric push rod is stopped from stretching out and drawing back, and after a proper amount of biological fluid is injected into the extraction barrel, a rotating motor is controlled to drive the mounting pipe to rotate in the extraction barrel; and meanwhile, the cleaning scraping plate rotates on the inner walls of the extraction barrel and the filter plate, so that cells accumulated on the inner wall of the filter plate are scraped, the filtered cells are prevented from blocking the filter plate, and the extraction efficiency is improved. The extraction of the exosome in the biological fluid in the extraction barrel is influenced.

The invention discloses a diabetic retinopathy diagnosis and analysis platform based on double body fluids and a method for analyzing a biological fluid sample by using the diabetic retinopathy diagnosis and analysis platform, and relates to the field of biological diagnos.The diabetic retinopathy diagnosis and analysis platform comprises an acquisition and analysis module and a machine learning module, the acquisition and analysis module acquires mass spectrum data of a biological sample through a mass spectrum system for analysis, and the machine learning module analyzes and processes the acquired mass spectrum data of the biological sample, constructs a diabetic retinopathy biomarker panel, and analyzes the diabetic retinopathy biomarker panel to obtain the diabetic retinopathy biomarker. The invention also comprises a method for analyzing a biological fluid sample by using the analysis platform, the biological fluid sample comprises vitreous humor and plasma, and the nanoparticles are used as a matrix of the biological fluid sample for mass spectrum data acquisition. The invention provides a rapid, stable, reliable and high-sensitivity vitreous humor metabonomics detection method and system.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A composition and method for preserving a wide variety of analyte classes, including but not limited to small molecules, peptides, proteins, nucleic acids, carbohydrates, and lipids, ensuring stability and reproducibility of their compartmental concentration over the time course of storage at room temperature, thus enabling cost-efficient tests and logistics for the analysis of these samples.

The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical, and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The fabrication process includes the steps of substrate fabrication, circuit fabrication, pick and place, reflow soldering, electrode fabrication, membrane fabrication, sealing and curing, layer bonding, and dressing. The physiological sensor is operable to analyze biological fluids such as sweat.

The invention relates to the technical field of adsorption materials, and particularly discloses a molecularly imprinted hydrogen bond organic framework adsorption material as well as a preparation method and application thereof. According to the material, tetra (4-sulfonyl phenyl) methane and 1, 1 '-diamino-4, 4'-dipyridyl diiodide are used as construction units to form a hydrogen bond organic framework substrate, and a hemp essence drug template molecule is introduced to construct a specific imprinting hole in the hemp essence drug template molecule. The preparation method is characterized in that the molar ratio X of template molecules to tetra (4-sulfonyl phenyl) methane is controlled to be 0.05-0.5, crystallization is performed in a water / methanol mixed solvent, and then elution and activation are performed through an acid solution with the pH being 2-4. The material has the advantages of high adsorption capacity, no less than 58 mg / g of template molecule adsorption capacity, high selectivity and rapid adsorption kinetics, achieves balance within 5 minutes, can efficiently enrich trace hemp extract drugs from a water environment or biological fluid, and solves the technical problem that the selectivity, the capacity and the mass transfer rate of the existing adsorption material are difficult to consider at the same time.

The invention discloses an aptamer sensor for detecting a novel psychoactive substance ketamine and application of the aptamer sensor. Belongs to the technical field of poison detection. The aptamer sensor for detecting the novel psychoactive substance ketamine is successfully established by taking a two-dimensional nano material as a fluorescence quencher and a carrier, chemically coupling the two-dimensional nano material with a double-chain nucleic acid aptamer through a liquid-phase amidation reaction and carrying out surface passivation treatment, so that the chemical coupling efficiency is greatly improved; and the stability and the sensitivity of the sensor are enhanced. In addition, when the sensor is introduced into complex biological matrixes such as blood, urine and saliva, the system does not display non-specific signals, and compared with a physical adsorption system, the KET in complex biological fluid can be reliably detected, and a new thought and method are provided for reliable detection of other novel psychoactive substances.

The application relates to the field of biological fermentation, and discloses a traditional Chinese medicine fermentation composition for repairing ovary cells and a preparation method thereof. The traditional Chinese medicine fermentation composition is obtained by subjecting traditional Chinese medicine raw materials to microbial liquid fermentation; the traditional Chinese medicine raw materials include lilies, angelica, sea buckthorn, raspberries and medlar in a mass ratio of (1-2):(1-2):(1-2):(1-2):(1-2). The traditional Chinese medicine fermentation composition is obtained by mixing lilies, angelica, sea buckthorn, raspberries and medlar in a specific proportion and subjecting the mixture to biological liquid fermentation. The traditional Chinese medicine fermentation composition has extremely high antioxidant activity and excellent ovary cell repairing function.

A biological fluid processing device includes pump and valve systems, a controller, and an optical detection assembly. During a biological fluid processing procedure, the controller controls the operation of the pump and valve systems to separate a cell-containing fluid from the blood of a blood source and controls the optical detection assembly to emit light through the cell-containing fluid. The controller receives signals from the optical detection assembly that are indicative of the intensity of light that has passed through the cell-containing fluid. The controller receives or calculates an adjustment factor that is derived from historical data reflecting a cell collection procedure previously executed for the same blood source in which the same type of cell was collected. The controller determines an adjusted cell concentration of the cell-containing fluid based at least in part on the signals from the light detector and the adjustment factor.

Methods and kits of rapidly isolating molecules from a sample are provided. Methods of treating a subject in need thereof using the rapid isolation kits and / or methods described herein are also provided. In some embodiments, the molecules are selected from ribosomes, DNA, RNA, and protein. In some embodiments, the sample is selected from a tissue sample, a blood sample, a non-blood biological fluid sample, and a whole organism sample.

The invention relates to a pair of anti-TSH receptor (TSHR) autoantibody-binding fusion proteins consisting of a capture fusion protein and a detection fusion protein, and a method for detecting autoantibodies to the thyroid stimulating hormone receptor (TSHR) in a biological fluid sample, which employs said fusion proteins pair. More specifically, the capture and detection fusion proteins of the pair of the invention comprise an extracellular domain of a human TSHR and a monomeric non-human immunoglobulin Fc domain, or fragment thereof, or a bacterial maltose binding protein (MBP). Also disclosed is a kit for carrying out the method of the invention. In a preferred embodiment, the method of the invention is a sandwich immunoassay.

A system provides for an ability to automatically identify one or more chemical components of a sample, especially a biological fluid sample, based on analysis of spectral data by at least one artificial intelligence module. The artificial intelligence module is able to be trained on a plurality of spectral data samples having known concentrations of individual chemicals and elements. The system is preferably used for spectral techniques such as UV / vis and near-infrared (NIR) spectrophotometry, but is also able to be used for other forms of spectroscopic techniques, including mass spectrometry, infrared (IR) spectrometry, X-ray spectroscopy, Raman spectrometry, or nuclear magnetic resonance (NMR) spectrometry.

The centrifugal pump (1) for biological fluids, comprises: - one hollow body (2) defining a pumping chamber (3) provided with at least one inlet port (4) and with at least one outlet port (5) of a biological fluid; - one rotor element (6), housed within the pumping chamber (3) and controllable in rotation around an axis of rotation (X), the rotor element (6) comprising at least one impeller body (7), which defines an upper surface (7 a) supporting a plurality of blades (8) adapted to convey the biological fluid to the outlet port (5), wherein the blades (8) have a relevant thrust surface (18) adapted to interact, in use, with the biological fluid to push it towards the outlet port (5), where stheaid thrust surface (18) runs from the upper surface (7a), is arranged transversely to the upper surface (7a) itself and defines a relevant mating profile (18a) with the upper surface (7a) and a relevant upper profile (18b) opposite the mating profile (18a), wherein the upper profile (18b) protrudes from the mating profile (18a) of the corresponding blade (8) towards the blade (8) arranged upstream with respect to the way of rotation of said rotor element (6).

A method for cleaning a blood filter comprises: (i) pumping a physiologically safe fluid in both directions through the inner and / or outer portions of a plurality of hollow fiber membranes of the blood filter to remove or separate blood residues, such as blood clots, proteins, and / or biological fluid; (ii) injecting air into the physiologically safe fluid to form an air / fluid mixture; (iii) pumping the air / fluid mixture through the inner and / or outer portions of the plurality of hollow fiber membranes of the blood filter to further remove or separate blood residues from it; and (iv) disposing of the physiologically safe air / fluid mixture with the removed or separated blood residues to the purge.

The invention relates to a sachet that prevents the technical problems caused by the presence of spaces between the polymers swelling spherically, which polymers reduce the volume of the fluid by removing water and other small molecules from the body fluid by means of elastic hydrophilic polymer meshed structures.