201 results about "Biological fluid" patented technology

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

Assays for detecting the level of soluble UNC5C in a biological fluid sample from a patient, and the use of such levels as markers of neurodegenerative disease presence and / or severity are described. Antibodies and fragments thereof capable of binding to UNC5C, and the use of such antibodies for detecting the level of soluble UNC5C in a biological fluid sample from a patient are also described, as well as methods for detecting the level of soluble UNC5C in a biological fluid sample from a patient using anti-UNC5C antibodies in a clinical context.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

The application relates to the technical field of free radical detection, in particular to a high-sensitivity in-situ capture and detection method of organic free radicals based on a DIPPMPO probe and application, and the method comprises the following steps: adding a chemical probe DIPPMPO into a reaction system containing potential organic free radical precursors, so that the DIPPMPO and organic free radicals generated in a reaction process occur adduct reaction to form a DIPPMPO-free radical adduct which can be detected under liquid chromatography-mass spectrometry conditions; performing high performance liquid chromatography-quadrupole-time of flight mass spectrometry analysis on a mixed solution after the adduct reaction is completed, so that first mass spectrometry data and secondary mass spectrometry fragment information of the DIPPMPO-free radical adduct are obtained; and automatically processing the secondary mass spectrometry data, screening out parent ions with continuous neutral loss as potential DIPPMPO-free radical adduct candidate signals. The application does not need derivatization, is simple to operate, is broad-spectrum and high-efficiency, and can be applied to environmental water samples, biological fluids, chemical reaction liquids or drug metabolism systems.

A method for activating a physiological signal sensing device through a handheld device to measure a physiological signal of an analyte in biological fluids is provided. The physiological signal sensing device includes a transmitter including a power unit, a switch unit, a magnetic field sensing unit and a processing unit. The method includes: establishing an inductive magnetic field between the handheld device and the transmitter, causing the magnetic field sensing unit to generate an inductive signal; in a first operating cycle, activating the switch unit by the inductive signal, causing the power unit to connect to the processing unit to activate the processing unit; providing an activation signal by the processing unit to turn on the switch unit; causing the switch unit to enter a self-maintaining state; and in a second operating cycle, connecting the power unit to the processing unit through the switch unit in the self-maintaining state.

Soluble gp120 (sgp120) is associated to HIV-1-induced immune dysfunction, such as chronic immune activation. However, the detection of sgp120 in biological fluids such as plasma, serum, cervicovaginal fluids, and cerebrospinal fluids is challenging. The present application relates to novel methods and kits for the detection of sgp120 in biological fluids. These methods and kits are based on the use of specific combinations of sgp120-binding molecules recognizing particular domains of sgp120, notably the N-terminal 8-stranded β-sandwich structure, the constant region 1 and 2 (C1-C2) portion, the bridging sheet of the Co-Receptor Binding Site (CoRBS), and / or the CD4-binding domain.

The present disclosure provides materials and methods related to the purification of a biologic from a biological fluid. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A composition and method for preserving a wide variety of analyte classes, including but not limited to small molecules, peptides, proteins, nucleic acids, carbohydrates, and lipids, ensuring stability and reproducibility of their compartmental concentration over the time course of storage at room temperature, thus enabling cost-efficient tests and logistics for the analysis of these samples.

The invention relates to the technical field of adsorption materials, and particularly discloses a molecularly imprinted hydrogen bond organic framework adsorption material as well as a preparation method and application thereof. According to the material, tetra (4-sulfonyl phenyl) methane and 1, 1 '-diamino-4, 4'-dipyridyl diiodide are used as construction units to form a hydrogen bond organic framework substrate, and a hemp essence drug template molecule is introduced to construct a specific imprinting hole in the hemp essence drug template molecule. The preparation method is characterized in that the molar ratio X of template molecules to tetra (4-sulfonyl phenyl) methane is controlled to be 0.05-0.5, crystallization is performed in a water / methanol mixed solvent, and then elution and activation are performed through an acid solution with the pH being 2-4. The material has the advantages of high adsorption capacity, no less than 58 mg / g of template molecule adsorption capacity, high selectivity and rapid adsorption kinetics, achieves balance within 5 minutes, can efficiently enrich trace hemp extract drugs from a water environment or biological fluid, and solves the technical problem that the selectivity, the capacity and the mass transfer rate of the existing adsorption material are difficult to consider at the same time.

The application relates to the field of biological fermentation, and discloses a traditional Chinese medicine fermentation composition for repairing ovary cells and a preparation method thereof. The traditional Chinese medicine fermentation composition is obtained by subjecting traditional Chinese medicine raw materials to microbial liquid fermentation; the traditional Chinese medicine raw materials include lilies, angelica, sea buckthorn, raspberries and medlar in a mass ratio of (1-2):(1-2):(1-2):(1-2):(1-2). The traditional Chinese medicine fermentation composition is obtained by mixing lilies, angelica, sea buckthorn, raspberries and medlar in a specific proportion and subjecting the mixture to biological liquid fermentation. The traditional Chinese medicine fermentation composition has extremely high antioxidant activity and excellent ovary cell repairing function.

A biological fluid processing device includes pump and valve systems, a controller, and an optical detection assembly. During a biological fluid processing procedure, the controller controls the operation of the pump and valve systems to separate a cell-containing fluid from the blood of a blood source and controls the optical detection assembly to emit light through the cell-containing fluid. The controller receives signals from the optical detection assembly that are indicative of the intensity of light that has passed through the cell-containing fluid. The controller receives or calculates an adjustment factor that is derived from historical data reflecting a cell collection procedure previously executed for the same blood source in which the same type of cell was collected. The controller determines an adjusted cell concentration of the cell-containing fluid based at least in part on the signals from the light detector and the adjustment factor.

Methods and kits of rapidly isolating molecules from a sample are provided. Methods of treating a subject in need thereof using the rapid isolation kits and / or methods described herein are also provided. In some embodiments, the molecules are selected from ribosomes, DNA, RNA, and protein. In some embodiments, the sample is selected from a tissue sample, a blood sample, a non-blood biological fluid sample, and a whole organism sample.

The invention relates to a pair of anti-TSH receptor (TSHR) autoantibody-binding fusion proteins consisting of a capture fusion protein and a detection fusion protein, and a method for detecting autoantibodies to the thyroid stimulating hormone receptor (TSHR) in a biological fluid sample, which employs said fusion proteins pair. More specifically, the capture and detection fusion proteins of the pair of the invention comprise an extracellular domain of a human TSHR and a monomeric non-human immunoglobulin Fc domain, or fragment thereof, or a bacterial maltose binding protein (MBP). Also disclosed is a kit for carrying out the method of the invention. In a preferred embodiment, the method of the invention is a sandwich immunoassay.

A system provides for an ability to automatically identify one or more chemical components of a sample, especially a biological fluid sample, based on analysis of spectral data by at least one artificial intelligence module. The artificial intelligence module is able to be trained on a plurality of spectral data samples having known concentrations of individual chemicals and elements. The system is preferably used for spectral techniques such as UV / vis and near-infrared (NIR) spectrophotometry, but is also able to be used for other forms of spectroscopic techniques, including mass spectrometry, infrared (IR) spectrometry, X-ray spectroscopy, Raman spectrometry, or nuclear magnetic resonance (NMR) spectrometry.

A method for cleaning a blood filter comprises: (i) pumping a physiologically safe fluid in both directions through the inner and / or outer portions of a plurality of hollow fiber membranes of the blood filter to remove or separate blood residues, such as blood clots, proteins, and / or biological fluid; (ii) injecting air into the physiologically safe fluid to form an air / fluid mixture; (iii) pumping the air / fluid mixture through the inner and / or outer portions of the plurality of hollow fiber membranes of the blood filter to further remove or separate blood residues from it; and (iv) disposing of the physiologically safe air / fluid mixture with the removed or separated blood residues to the purge.

The invention relates to a sachet that prevents the technical problems caused by the presence of spaces between the polymers swelling spherically, which polymers reduce the volume of the fluid by removing water and other small molecules from the body fluid by means of elastic hydrophilic polymer meshed structures.

The present invention describes a comprehensive system and method for the simultaneous early detection of multiple cancers in a single analysis. The system involves a Liquid Chromatography-Mass Spectrometry (LC-MS) device coupled with processors and AI / ML algorithms. The LC-MS device analyses metabolite ions from dried extracts of biological fluid samples, aligning and normalizing the data while minimizing errors. Quality control processes, including a neural network model and critical ion monitoring, ensure accurate detection. The system employs AI / ML processes to create two models: the Cancer Detection AI (CDAI) Model for identifying cancerous samples, and the Tissue of Origin Identification (TOOAI) Model for distinguishing specific cancer types. The models are applied to test samples, providing scores based on tissue of origin probabilities. The invention aims to revolutionize early cancer detection through advanced analytical and machine learning techniques.

The present disclosure relates to a biological fluid processing system and method. The system comprises a fluid processing device comprising at least one fluid path, a pump for providing a pressure in the at least one fluid path, a valve arranged along said fluid path and a first actuator arranged to control the valve to assume a desired opening state of said fluid path. The biological fluid processing system comprises further a processing interface comprising a pump drive for driving the pump of the fluid processing device, and a processing control element comprising a pump control system arranged to control at least the pump drive and a valve control system arranged to control the first actuator. The system is modular. The fluid processing device is comprised in a fluid processing device module having a predetermined fluid processing device configuration. The processing interfaces have a predetermined processing interface configuration. The processing control element is arranged to receive information relating to the predetermined processing interface configuration of the processing interface module and / or the predetermined fluid processing device configuration of the fluid processing device module and control the at least one pump drive and / or the valve based on the received information relating to the predetermined fluid processing device configuration and the predetermined processing interface configuration.

1. The name of the design product: electrode of biosensor assembly (two). 2. The use of the design product: for forming biosensor assembly, biosensor assembly containing electrode and other components of biosensor, such as fluid channel, jointly forming biosensor for detecting biological fluid sample. 3. The design points of the design product: in the front view. 4. The picture or photo that can best show the design points: front view. 5. Other circumstances that need to be explained: the non-dotted part is the local part that needs to be protected, and the line is displayed in accordance with the projection rules of each view.

The present invention provides a light-activated lateral flow immunosensor reagent strip, a detection and analysis method, and its application. The reagent strip comprises an electrode substrate, a conjugate pad, a sample backing layer, a chromatographic membrane, and a water-absorbing pad. The sample backing layer, conjugate pad, chromatographic membrane, and water-absorbing pad are connected end to end and sequentially overlapped and affixed to the electrode substrate. The light-activated lateral flow immunosensor reagent strip is used for the quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid, or urine.

The utility model discloses a biological fluid continuous disinfection system in the technical field of disinfection systems. The biological fluid continuous disinfection system comprises biological fluid, a feeding system, a preheating system, a heating system, a maintaining system and a cooling system, the feeding system comprises a storage tank, a liquid level sensor, cleaning liquid, first industrial steam, a filter, a conveying pump and a flow meter, the preheating system comprises at least one preheater, biological fluid conveyed by the conveying pump flows through the preheater, the biological fluid flowing through the maintaining system flows through the preheater through a pipeline, and the pipeline is communicated with the storage tank. The biological fluid flowing through the maintaining system preheats the biological fluid conveyed by the conveying pump; the heating system comprises a heater, second industrial steam and a proportioning valve, the maintaining system comprises a maintaining pipe, a maintaining tank and a temperature sensor, and the cooling system comprises a cooler, a cooling water inlet pipe, a cooling water outlet pipe and a discharging tank.

The present invention describes a comprehensive system and method for the simultaneous early detection of multiple cancers in a single analysis. The system involves a liquid chromatography-mass spectrometry (LC-MS) instrument coupled with a processor and AI / ML algorithms. The LC-MS instrument analyzes metabolite ions from dried extracts of biological fluid samples and aligns and normalizes the data while minimizing errors. Quality control processes, including neural network models and critical ion monitoring, ensure accurate detection. The system employs an AI / ML process to create two models: a Cancer Detection AI (CDAI) model for identifying cancer samples and a Tissue of Origin Identification (TOOAI) model for distinguishing specific cancer types. These models are applied to test samples and provide a score based on tissue of origin probability. The present invention aims to revolutionize early cancer detection through advanced analytical and machine learning techniques.

The present disclosure provides devices, systems, and methods for the point-of-care analysis of target analytes in biological fluids by binding assays. The present disclosure includes a cartridge for collecting target analytes contained in a fluid sample and performing an assay. The cartridge includes an assay stack having a first separation layer, a second separation layer, and a detection membrane. The cartridge also includes a plurality of first complexes containing capture molecules and magnetic beads and a plurality of second complexes containing detection molecules and detection labels. Further, the detection membrane contains a substrate that interacts with the detection labels to initiate a quantifiable reaction in the presence of the target analytes. The quantifiable reaction corresponds to the amount of detection antibodies present in the detection membrane, and the amount of detection antibodies present corresponds to the amount of target analytes present.

A biological fluid information acquisition apparatus includes a light source, a prism, a first light receiving element, a second light receiving element, a differential circuit, and a signal processing unit. The prism has a first boundary face that branches a laser beam emitted from the light source into a first luminous flux and a second luminous flux, a second boundary face that totally reflects the second luminous flux, a third boundary face that totally reflects the second luminous flux reflected by the second boundary face, and a fourth boundary face emitting the second luminous flux reflected by the third boundary face, and, when a width direction of the biological fluid information acquisition apparatus is an X direction and a thickness direction of the biological fluid information acquisition apparatus orthogonal to the X direction is a Y direction, an interval between the second boundary face and the third boundary face in the Y direction is shorter than an interval between the first boundary face and the fourth boundary face in the X direction.

A magnetic selector includes a housing configured to receive a container and having a floor upon which the container is disposed. The selector also includes a magnet carrier disposed on an opposite side of the floor from the container. The magnet carrier has at least one magnet disposed thereon and being moveable relative to the floor between a first state wherein the magnet carrier is adjacent the floor and a second state wherein the magnet carrier is spaced from the floor. The selector may include a door. The magnetic selector is usable in a fluid processing system that includes a fluid processor connectable to a source container filled with a biological fluid. A container is disposed in the magnetic selector and connected to the processor along a fluid pathway. The processor is configured to separate the biological fluid from the source container into at least two streams of material.