391 results about "Biological fluid" patented technology

A wearable device consists of a smart band and a display unit. The smart band comprises a microbial biosensor, a particulate matter sensor, an enviro sensor, a physiological sensor, a biofluid sensor, a biokinetics sensor, a lifestyle sensor, and a single board computer. The microbial biosensor detects, measures, and monitors microorganisms, and a sterilizer kills pathogens. The particulate matter sensor detects, measures, and monitors a set of suspended particles in the surrounding air. The enviro sensor monitors environmental conditions surrounding the user. The biofluid sensor detects, measures, and monitors biological fluid parameters of the user. The physiological sensor detects, measures, and monitors physiological parameters of the user. The biokinetics sensor detects, measures, and monitors physical activities of the user. The lifestyle sensor detects, measures, and monitors healthy lifestyle activities of the user. The wearable device allows for continuous monitoring of user health for accurate clinical outcomes and wellness programs.

The invention belongs to the technical field of biological liquid sample detection, and particularly relates to a liquid path system for sample suction quality detection and an anomaly detection process. A liquid path system for sample suction quality detection comprises a capacitance detection module, an injector, a pressure detection module, a cleaning valve, a cleaning pump, a degassing module and a water tank which are connected in sequence, and the capacitance detection module, the injector, the pressure detection module, the cleaning valve, the cleaning pump, the degassing module and the water tank are connected through pipelines. The method mainly solves the following problems: 1, the contradiction between the pressure monitoring range and the monitoring resolution; 2, when the sample is insufficient or bubbles are sucked, the difference between the suction pressure and the normal liquid suction pressure is small, so that misjudgment is easily caused; 3, misjudgment is easily caused by noise signal interference; 4, corresponding error monitoring mechanisms are lacked in other processes such as cleaning, sample adding and the like; and 5, monitoring is performed by excessively depending on a single mode, and the pressure is easily interfered in the testing process.

The disclosure provides an extracorporeal devices, systems and methods for removing a pathogen or a toxin from a biological fluid of a subject comprising contacting a biological fluid from the subject with a loosely packed bed of adsorption media, such as a fluidized bed, wherein the adsorption media comprises heparin, to remove the pathogen or the toxin to form a treated biological fluid; and infusing the treated fluid into the subject.

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

Disclosed herein is a device and method for measuring spatial mass distribution profiles to weigh the accumulated-aggregated mass of an analyte in a crowded bioorganic material background by employing a high frequency recognition pattern. The recognition pattern allows for the Fourier filtering of mass sensitive image data for background and noise subtraction. The device and method enables the screening of a biological fluid sample for an analyte associated with proteinopathy.

The invention provides a light-excited lateral flow immunosensor reagent strip, a detection analysis method and application of the light-excited lateral flow immunosensor reagent strip. The reagent strip comprises an electrode substrate, a combination pad, a sample pad layer, a chromatography membrane and a water absorption pad, and the sample pad layer, the combination pad, the chromatography membrane and the water absorption pad of the reagent strip are connected end to end and are sequentially overlapped and pasted on the electrode substrate. The light-excited lateral flow immunosensor reagent strip is applied to quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid or urine.

Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

The invention discloses a full-automatic intelligent physical and chemical detection work station, relates to the technical field of biological fluid purification and extraction, and solves the problems of poor procedure connection and low detection efficiency of physical and chemical detection of body fluid. The test tube rotating module comprises a rotatable rotating table, a plurality of clamping mechanisms respectively used for clamping test tubes with different diameters, a pushing and pressing mechanism matched with one of the clamping mechanisms, and a loosening mechanism for controlling the clamping mechanisms to loosen the test tubes; the reagent rotating module is located below the test tube rotating module, the reagent rotating module comprises a rotatable rotating disc, and a plurality of placing positions for placing reagent bottles are arranged in the circumferential direction of the rotating disc; and at least one lifting mechanism. According to the invention, all procedures of purification operation of biological fluid can be seamlessly connected, the types of reagents can be automatically selected according to different types of the biological fluid, and the efficiency of physical and chemical detection is greatly improved.

The invention relates to a real-time enrichment and detection method for extracellular vesicles. Belongs to the technical field of biological detection. The preparation method comprises the following steps: firstly, preparing a silicon dioxide colloidal crystal (SCC) thin film by adopting a vertical evaporation method; then modifying distearoyl phosphatidyl ethanolamine-polyethylene glycol-carboxyl (DSPE) on the silicon dioxide colloidal crystal film, and separating and enriching the extracellular vesicles in the biological liquid by utilizing the affinity characteristic of the DSPE and a phospholipid bilayer; then constructing a reflection interference spectrum system, and detecting the extracellular vesicles in real time by utilizing optical thickness change caused in the process of separating the extracellular vesicles; according to the method, the extracellular vesicles in various biological liquids can be rapidly and efficiently separated, and real-time concentration and membrane protein expression quantity analysis can be carried out on the separated extracellular vesicles; the invention provides a rapid and low-cost integrated multifunctional analysis method for separation of extracellular vesicles of various body fluids.

A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.

Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and / or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.

Apparatus and associated methods relate to lyophilizing a solid phase composition (SPC). In an illustrative example, the SPC is received in a frozen state in a first packaging. The SPC may be, for example, transferred into a second packaging having a thermally conductive layer, mechanically distributed to a predetermined maximum thickness to form a block having at least one homogenous dimension, and provided with a heat source configured to communicate substantially all thermal energy to the SPC via the thermally conductive second layer. In some embodiments, the SPC may be maintained in the frozen state. For example, the lyophilized SPC may be transferred to a third packaging. Various embodiments may limit physical contacts with the SPC to the first packaging, the second packaging, and the third packaging. Various embodiments may advantageously maintain sanitation, retain nutrients of the SPC, and / or promote consistent results from the lyophilization process.

A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.

Provided herein are systems and methods for implementing a modular light device for use in an electronic processing device according to embodiments of the present disclosure. In one or more embodiments, the modular light device can be implemented as a separate component that can be inserted into or removed from the processing device. In one or more embodiments, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, and the light source array chamber can include one or more light source arrays and light sensors collectively configured as part of the light device to illuminate a biological sample with light.

Assays for detecting the level of soluble UNC5C in a biological fluid sample from a patient, and the use of such levels as markers of neurodegenerative disease presence and / or severity are described. Antibodies and fragments thereof capable of binding to UNC5C, and the use of such antibodies for detecting the level of soluble UNC5C in a biological fluid sample from a patient are also described, as well as methods for detecting the level of soluble UNC5C in a biological fluid sample from a patient using anti-UNC5C antibodies in a clinical context.

A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and / or extreme pressures.

The application relates to the technical field of free radical detection, in particular to a high-sensitivity in-situ capture and detection method of organic free radicals based on a DIPPMPO probe and application, and the method comprises the following steps: adding a chemical probe DIPPMPO into a reaction system containing potential organic free radical precursors, so that the DIPPMPO and organic free radicals generated in a reaction process occur adduct reaction to form a DIPPMPO-free radical adduct which can be detected under liquid chromatography-mass spectrometry conditions; performing high performance liquid chromatography-quadrupole-time of flight mass spectrometry analysis on a mixed solution after the adduct reaction is completed, so that first mass spectrometry data and secondary mass spectrometry fragment information of the DIPPMPO-free radical adduct are obtained; and automatically processing the secondary mass spectrometry data, screening out parent ions with continuous neutral loss as potential DIPPMPO-free radical adduct candidate signals. The application does not need derivatization, is simple to operate, is broad-spectrum and high-efficiency, and can be applied to environmental water samples, biological fluids, chemical reaction liquids or drug metabolism systems.

A method for activating a physiological signal sensing device through a handheld device to measure a physiological signal of an analyte in biological fluids is provided. The physiological signal sensing device includes a transmitter including a power unit, a switch unit, a magnetic field sensing unit and a processing unit. The method includes: establishing an inductive magnetic field between the handheld device and the transmitter, causing the magnetic field sensing unit to generate an inductive signal; in a first operating cycle, activating the switch unit by the inductive signal, causing the power unit to connect to the processing unit to activate the processing unit; providing an activation signal by the processing unit to turn on the switch unit; causing the switch unit to enter a self-maintaining state; and in a second operating cycle, connecting the power unit to the processing unit through the switch unit in the self-maintaining state.

Soluble gp120 (sgp120) is associated to HIV-1-induced immune dysfunction, such as chronic immune activation. However, the detection of sgp120 in biological fluids such as plasma, serum, cervicovaginal fluids, and cerebrospinal fluids is challenging. The present application relates to novel methods and kits for the detection of sgp120 in biological fluids. These methods and kits are based on the use of specific combinations of sgp120-binding molecules recognizing particular domains of sgp120, notably the N-terminal 8-stranded β-sandwich structure, the constant region 1 and 2 (C1-C2) portion, the bridging sheet of the Co-Receptor Binding Site (CoRBS), and / or the CD4-binding domain.

The present invention belongs to the field of detection and inspection technology, and provides a MXene material modified by nanosilver, and a preparation method and application thereof. The method comprises the following steps: mixing MAX material, lithium fluoride and hydrochloric acid solution for etching to obtain a multilayer MXene material; mixing the multilayer MXene material and dimethyl sulfoxide for suction filtration to obtain a MXene film; coating the silver nitrate solution on the surface of the MXene film for heating to obtain a MXene material modified by nanosilver. The MXene material modified by nanosilver prepared by the present invention realizes the rapid non-invasive (or low-invasive) diagnosis of paraquat poisoning patients using biological fluid samples such as blood and urine, the rapid detection of herbicides in fruits and vegetables, and the efficient detection of chemical drug additions in traditional Chinese veterinary medicines. The present invention can be widely used in the field of biological detection technology and has strong practicality.

The present disclosure provides materials and methods related to the purification of a biologic from a biological fluid. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.

The invention discloses an exosome extraction device and method, and belongs to the technical field of exosome extraction.The exosome extraction device is provided with a rotating motor, an extraction barrel, a mounting pipe, an electric push rod, a rotating top strip, a cleaning scraper and a filter plate, and the rotating top strip rotates between a first rotating seat and a second rotating seat which correspond to each other; meanwhile, a top strip is rotated to jack up a connecting plate to be away from a mounting pipe until a cleaning scraping plate is tightly attached to the inner wall of the extraction barrel and a filter plate, the electric push rod is stopped from stretching out and drawing back, and after a proper amount of biological fluid is injected into the extraction barrel, a rotating motor is controlled to drive the mounting pipe to rotate in the extraction barrel; and meanwhile, the cleaning scraping plate rotates on the inner walls of the extraction barrel and the filter plate, so that cells accumulated on the inner wall of the filter plate are scraped, the filtered cells are prevented from blocking the filter plate, and the extraction efficiency is improved. The extraction of the exosome in the biological fluid in the extraction barrel is influenced.

A method for the diagnosis of diseases, in particular hematological malignancies or solid tumors, in a subject comprises the steps of isolating (21,61) an extracellular vesicle pellet (3a,3b) obtained from a sample (2) of a biological fluid previously taken from the subject; measuring (31,41,51-52), from said pellet, parameters representative of the six biomarkers (I) size, (II) total amount of the extracellular vesicles, (III) amount of the extra- cellular vesicles expressing on their own surface (III) a first antigen and (IV) a first and a second antigen, (V) mean fluorescence intensity for each of said antigens and (VI) nucleic acid content of the extracellular vesicles; performing a first comparison of the biomarker-representative parameters with respective cut-off values; assigning a partial score to each parameter or to the six biomarkers on the basis of the above first comparison step; calculating a final score, i.e. a subject score, as the sum of the partial scores; performing a second comparison of the final score with at least one predetermined diagnostic threshold value, preferably with two diagnostic upper and lower values; estimating the probability diagnosis of said pathology on the basis of the above second comparison step. The combination of the six biomarkers, in the context of personalized medicine, overcomes the prior art method limitations due to the high clinical heterogeneity between subjects, in terms of sensitivity, with reference to a given pathology, for one rather than the other biomarkers and their relative parameters selected from the six.

The invention relates to the technical field of filtration of biological fluids and products, in particular to a filtration system and a method thereof. A first filter unit having a first end and a second end and in fluid communication with the processing vessel; a second filter unit having a first end and a second end and in fluid communication with the processing vessel; the driver is used for generating a magnetic field; an alternating flow pump connected to a first end of the first filter unit and a second end of the second filter unit, the alternating flow pump having a mover fully sealed within a pump chamber, the mover being capable of generating a magnetic field coupled to the driver magnetic field, and the driver drives the rotor to reciprocate in the pump chamber by controlling the change of the magnetic field so as to pump fluid from the processing container through the first filter unit and the second filter unit.

The invention discloses a diabetic retinopathy diagnosis and analysis platform based on double body fluids and a method for analyzing a biological fluid sample by using the diabetic retinopathy diagnosis and analysis platform, and relates to the field of biological diagnos.The diabetic retinopathy diagnosis and analysis platform comprises an acquisition and analysis module and a machine learning module, the acquisition and analysis module acquires mass spectrum data of a biological sample through a mass spectrum system for analysis, and the machine learning module analyzes and processes the acquired mass spectrum data of the biological sample, constructs a diabetic retinopathy biomarker panel, and analyzes the diabetic retinopathy biomarker panel to obtain the diabetic retinopathy biomarker. The invention also comprises a method for analyzing a biological fluid sample by using the analysis platform, the biological fluid sample comprises vitreous humor and plasma, and the nanoparticles are used as a matrix of the biological fluid sample for mass spectrum data acquisition. The invention provides a rapid, stable, reliable and high-sensitivity vitreous humor metabonomics detection method and system.

The present invention relates to a method by which intravenous fluids, blood or artificial blood containing high levels of mechanically infused dissolved oxygen can be used to maintain appropriate oxygen levels in venous blood to provide short term oxygenation support to a compromised patient or trauma patient. In one aspect, a system and method for oxygenating a biological fluid for a compromised subject or trauma subject in need of oxygenation support to maintain the subject at an appropriate oxygen level is provided, the method comprising: supplying oxygen from an oxygen source; and dissolving an amount of the supplied oxygen into the biological fluid to obtain an oxygen enriched biological fluid.

A composition and method for preserving a wide variety of analyte classes, including but not limited to small molecules, peptides, proteins, nucleic acids, carbohydrates, and lipids, ensuring stability and reproducibility of their compartmental concentration over the time course of storage at room temperature, thus enabling cost-efficient tests and logistics for the analysis of these samples.