5186 results about "Metabolite" patented technology

A fused ring compound, a pharmaceutical composition comprising same, and the use thereof. The compound has a structure as represented by formula (I), or is a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer or a mixture form thereof, a metabolite, a metabolic precursor, an isotope-substituted form, a pharmaceutically acceptable salt, a hydrate, a solvate, a polymorph or a co-crystal thereof. The compound can be used for treating one or more cancers caused by KRAS mutation.

Compounds represented by general formula (I), or stereoisomers, tautomers, deuterated substances, solvates, prodrugs, metabolites, and pharmaceutically acceptable salts or eutectic crystals thereof, an intermediate thereof, and the use thereof in diseases related to KRAS inhibition or degradation such as cancers.

A fused ring compound, a pharmaceutical composition comprising same, and a use. The compound has a structure represented by formula (I) or a tautomer, mesomere, racemate, enantiomer, diastereomer or mixture thereof, metabolite, metabolic precursor, isotope substitution form, pharmaceutically acceptable salt, hydrate, solvate, polymorph or eutectic thereof. The compound can be used for treating a cancer caused by KRAS mutations, and said cancer is selected from one or more cancers caused by KRAS G12C, KRAS G12V, KRAS G12A and G12D mutations. In particular, the compound can serve as a G12D inhibitor and has relatively high inhibitory activity.

The invention relates to a compound shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal of the compound, an intermediate of the compound, and application of the compound in inhibiting or degrading Kras related diseases such as cancers. B-L-K (I)

Provides heterocyclic compounds and use thereof, specially relates to a compound represented by Formula (I), a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a solvate thereof, a crystal form thereof, a metabolite thereof or a prodrug thereof, further relates to a PROTAC comprising a compound of Formula (I), a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a solvate thereof, a crystal form thereof, a metabolite thereof or a prodrug thereof. The heterocyclic compounds can be used for preventing or treating a SOS l-associated disease.

The present invention relates to an oxo-tricyclic derivative and the pharmaceutical use thereof, in particular to a compound as shown in general formula (I), or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a cocrystal thereof, an intermediate thereof, a preparation method therefor, and the use thereof in the preparation of a drug for treating diseases associated with WRN activity or expression level.

The invention provides a tetrahydropyridinopyrazole derivative and application thereof in medicine, and particularly relates to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic of the compound, and an intermediate and a preparation method of the tetrahydropyridinopyrazole derivative. The invention also relates to application in preparation of related medicines for treating diabetes mellitus. # imgabs0 #

Disclosed is a system for detecting whether the breast cancer is benign or malignant based on multiple modalities, which comprises: an ultrasonomics model configured to extract breast tumor position information and breast tumor morphological features on the basis of an acquired grayscale breast ultrasound image, perform global interactive fusion on the breast tumor position information and breast tumor morphological feature information, and convert a Transformer encoder-based feature output into an output vector of the corresponding classification dimensions by means of a fully connected layer; a metabonomics model configured to obtain a metabolic fingerprint spectrogram and analyze the metabolic fingerprint spectrogram on the basis of a metabolic database and a predetermined significantly differential metabolite to obtain abnormal metabolic pathways, signal transduction pathways, and related biochemical reactions associated with breast cancer malignancy; and a detection module configured to perform joint modeling, based on the breast tumor position information, the breast tumor morphological features, and a peak value of the significantly differential metabolite of the breast cancer malignancy, to output a prediction result about whether the breast cancer is benign or malignant.

A spiro compound, and a preparation method therefor and a use thereof. Specifically, the present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, solvate, N-oxide, isotopically labeled compound, metabolite, or prodrug thereof, a pharmaceutical composition comprising the compound, a preparation method therefor, and a use thereof in preparation of a drug for preventing or treating KRAS-mediated related diseases.

The invention provides an early-stage automatic identification method and system for acute kidney injury related to cardiac surgery, and relates to the technical field of physiological parameter detection. The method comprises the following steps: acquiring average arterial pressure, cardiac blood discharge volume, central venous pressure and blood oxygen saturation, regularly recording and extracting data of adjacent time points, calculating a variation range, screening a mutation region, judging whether a reference range is exceeded or not, analyzing a multi-parameter synchronous variation condition, and marking a hemodynamics abnormal state. According to the method, abnormal changes of hemodynamics and urine metabolism are accurately recognized through real-time monitoring and multi-parameter analysis, the urine flow rate and the metabolite excretion rate are combined, misjudgment of a single index is avoided, the fineness of renal function change analysis is improved, the high-risk time period is accurately positioned through time cross comparison, the diagnosis accuracy is improved, and the diagnosis accuracy is improved. Trend analysis and risk grade division enable the change of the illness state to be more visual, and a real-time early warning system effectively monitors the fluctuation trend, optimizes clinical management and improves the timeliness of medical response.

The invention discloses a streptomycete recombinant engineering strain for producing mycosporine-like metabolites, a gene expression cassette is integrated in a genome of the streptomycete recombinant engineering strain, the gene expression cassette is recombined to an attB site of a chromosome in a streptomycete chassis strain, the gene expression cassette is an operon controlled by a single promoter, and the operon is an operon controlled by a single promoter. The operon comprises 2-4 biosynthetic gene elements in MysA, MysB, MysC and MysD or mysDp334 in a synthetic pathway of mycosporine-like metabolites. The invention also discloses a construction method of the streptomyces recombinant engineering strain and an application of the streptomyces recombinant engineering strain in preparation of the mycosporine-like metabolites. A mycosporine-like metabolite is efficiently produced by heterologous expression of a mycosporine-like metabolite synthesis gene element in streptomyces, and four mycosporine-like metabolite products with high yield and strong ultraviolet absorption activity can be obtained by reconstruction of the biosynthesis gene element and recombinant expression in streptomyces pluvialis.

The invention discloses a gastric cancer recurrence risk prediction method based on metabonomics characteristic analysis. The method comprises the following steps: S1, constructing a metabonomics data set; s2, the collected metabonomics data set is preprocessed; s3, extracting metabolite characteristics related to gastric cancer recurrence; s4, based on the extracted metabolite features, using a metabolic pathway integration method to quantify disturbance of each metabolic pathway, and calculating the abnormal degree of metabolite concentration change in the metabolic pathways; s5, constructing a multi-dimensional feature matrix containing a metabonomics data set, metabolic pathway integrals and patient individual information; s6, inputting the multi-dimensional feature matrix into a trained machine learning model, and outputting a gastric cancer recurrence risk score of the patient; and S7, generating a prediction report according to the recurrence risk score. According to the method, by combining metabonomics characteristic analysis, the space-time coupling quantum optimization network and the nonlinear disturbance model, the problems of insufficient real-time performance and insufficient data integration in gastric cancer recurrence risk prediction in the prior art are solved.

The invention relates to a magnetic resonance system frequency calibration method and device, equipment, a storage medium and a product. The method comprises the following steps: carrying out first scanning on a to-be-scanned object by utilizing a selective water excitation sequence to obtain a first echo signal; performing second scanning on the to-be-scanned object by using the selective water excitation sequence to obtain a second echo signal; according to the first echo signal and the second echo signal, the frequency drift amount of the magnetic resonance system in the current time period is calculated; and calibrating the frequency of the radio frequency coil of the magnetic resonance system according to the frequency drift amount of the magnetic resonance system in the current time period. According to the method and the device, the system frequency is calibrated by the selective water excitation sequence, and the selective water excitation sequence only excites the water signal and does not excite other types of signals including metabolite signals; therefore, the stability of the metabolite signal is not influenced, the accuracy of the target metabolite signal is not influenced, and the quality of the spectrum image is not influenced.

A WRN helicase-inhibiting bis-heterocyclic derivative, a pharmaceutical composition containing same, and use thereof. Specifically, a compound represented by formula (I), a stereoisomer thereof, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a crystal form thereof, an isotopic derivative thereof, a prodrug thereof, a metabolite thereof, a solvate thereof, or a hydrate thereof, a composition containing the compound, and use thereof as a WRN helicase inhibitor, which can be used to prepare a drug for treating WRN helicase-mediated diseases.

Provided in the present invention are a tetrahydropyridopyrazole derivative and use thereof in medicine. Specifically provided is a compound as shown in general formula (I) or a racemate, stereoisomer, tautomer, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate thereof, a preparation method therefor, and use thereof in the preparation of a related drug for treating diabetes or obesity.

The invention relates to the field of fertilizers, in particular to a stable fertilizer for preventing and treating peanut root rot and a preparation method thereof, and the fertilizer comprises a fertilizer inner core layer, a nano microbial metabolite layer and a microbial protective layer from inside to outside. According to the stable fertilizer for preventing and treating peanut rhizome rot, the capsule embedding inhibitor made of humic acid and the trichoderma aureoviride metabolite are adopted to construct a dual nitrification inhibition system, and the capsule embedding inhibitor and the trichoderma aureoviride metabolite have a synergistic effect, so that the nitrification effect is reduced, the nitrogen fertilizer utilization rate is increased, and non-point source pollution is reduced.

The invention discloses an intelligent regulation and control method for a tea fermentation process and a regulation and control system based on microbial activity monitoring, and relates to the technical field of tea processing. According to the method, microbial activity and environmental parameters are monitored in real time, and a microbial metabolism model and a neural network algorithm are combined, so that dynamic optimization and accurate regulation and control of the tea leaf fermentation process are realized, firstly, microbial activity data and environmental parameters in a fermentation environment are collected by utilizing a sensor array; the method comprises the following steps: firstly, calculating a metabolite generation rate and a concentration change trend through a microbial metabolism model, accurately identifying abnormal fluctuation in a fermentation process, secondly, adjusting fermentation conditions in real time based on the metabolite concentration change trend and a dynamic regulation and control algorithm to ensure the stability of the fermentation process, and finally, carrying out real-time fermentation. Tea quality parameters after fermentation condition adjustment are predicted through a neural network algorithm, a regulation and control strategy is optimized, and stable improvement of tea quality is achieved.

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention discloses a metabonomics data batch correction method based on multi-kernel learning, and belongs to the cross technical field of bioinformatics and analytical chemistry. According to the method, the multi-kernel learning technology is utilized, the advantages of different kernel functions are fused in a self-adaptive mode, a model conforming to data reality is constructed, complex drift characteristics of metabolite signals are accurately captured, and efficient and accurate normalization processing of metabonomics data is achieved. Compared with traditional data standardization methods such as SVR and LOESS, the method has the advantages that the performance is excellent in the aspect of reducing the metabolite peak intensity variability, and the data stability is remarkably improved. In the subsequent multivariate statistical analysis, the classification accuracy is greatly improved, the comparability among different batches of data is also remarkably enhanced, reliable data support can be provided for discovery of disease biomarkers, and the method plays a key role in large-scale metabonomics research.

The invention relates to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or co-crystal of the compound, an intermediate of the compound, and application of the compound in inhibiting or degrading KRAS related diseases such as cancers. # imgabs0 #

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum 9A-2 and application thereof in preparation of products for regulating intestinal tracts and protecting eyes. A probiotic product is successfully researched and developed on the basis of the lactobacillus plantarum, and verification shows that the lactobacillus plantarum can continuously provide endophytic essential isorhamnetin, chromium and vitamin H in the intestinal reproduction and growth process while regulating intestinal flora balance and promoting digestion, and also has the effect of relieving visual fatigue; particularly, visual fatigue caused by eye related diseases is relieved. The endophytic essential quantity of isorhamnetin, chromium and vitamin H can be continuously provided in the intestinal reproduction and growth process by feeding 3 billion strains and 200 milligrams of metabolites of the strain every day, visual fatigue caused by eye related diseases can be prevented and relieved, and the body health can be kept.

The invention relates to application of a combined pharmaceutical composition in preparation of a medicine for resisting transforming follicular lymphoma. Active components in the combined pharmaceutical composition comprise a first component and a second component, the first component is selected from any one or a combination of at least two of sitagliflozin, pharmaceutically acceptable salt, isomer, solvate and metabolite of sitagliflozin; and the second component is selected from any one or a combination of at least two of chidamide, pharmaceutically acceptable salts, isomers, solvates and metabolites of the chidamide. Research finds that the combined use of the two active components not only can reduce the dosage of each drug and improve the medication safety, but also has the effect of improving or treating convertible follicular lymphoma more remarkably than that of a single drug active component, and plays a role in synergistic promotion. The invention provides an effective drug combination strategy for improvement or treatment of convertible follicular lymphoma, and has very significant significance.

The invention relates to the technical field of environment-friendly biological rare earth recovery, in particular to a Pristia megaterium MeR-2 and a method for leaching rare earth elements in waste by using the Pristia megaterium MeR-2. Specifically, the invention provides a method for leaching rare earth elements in waste by using microorganisms and metabolites thereof, and solves the problems of large dosage of chemical reagents, high production cost, serious environmental pollution and the like in the chemical leaching process of rare earth waste. The strain provided by the invention is low in culture cost, high in growth speed and simple in leaching condition, has the capability of leaching rare earth ions in various wastes, and has a relatively good application prospect in the aspects of rare earth waste microorganism recovery and reutilization and the like.

Pet food compositions and methods for improving the wellness of a pet are disclosed herein. In one aspect, provided is a pet food composition comprising about 10 wt. % or more of fat, the fat comprising one or more short chain triglyceride; a protein; and a fiber, wherein all weight percentages are based on the total weight of the pet food composition on a dry matter basis. In another aspect, a method is provided for improving the concentration of metabolite beta-hydroxybutyrate in a pet by providing a pet food composition comprising protein, fiber, and about 7 wt. % or more of fat, the fat comprising one or more short chain triglyceride, wherein the metabolite beta-hydroxybutyrate increases by about 5% or more an hour after consumption of the pet food composition by a pet and the glucose to ketone index decreases by 10% or more.

The invention provides a diheterocyclic derivative for inhibiting WRN helicase, a pharmaceutical composition containing the diheterocyclic derivative and application of the diheterocyclic derivative. Specifically, the invention provides a compound as shown in a formula (I), a stereoisomer thereof, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a crystal form thereof, an isotope derivative thereof, a prodrug thereof, a metabolite thereof, a solvate thereof or a hydrate thereof. The invention also provides a composition containing the compound and application of the composition as a WRN helicase inhibitor, and the composition can be used for preparing medicines for treating WRN helicase mediated diseases. # imgabs0 #

The invention provides a feed fermentation parameter intelligent correction method based on the Internet of Things, and the method comprises the steps: carrying out the full-dimensional data collection from a microenvironment in a feed fermentation tank to a cross-regional macroenvironment, and generating a standardized data matrix; detecting communication time delay fluctuation characteristics based on the standardized data matrix, determining a fluctuation period and an amplitude range of a time delay abnormal point, and forming a time delay fluctuation characteristic spectrum; analyzing the influence of a raw material nutrition structure and logistics transportation time efficiency on the purity and concentration uniformity of metabolites through a regional differentiation regulation and control plan, and outputting associated feature distribution of quality control imbalance between regions; and updating an operation instruction of the feed fermentation equipment in real time according to the association feature distribution of the quality control imbalance between the regions, and obtaining equipment state operation feedback data after the operation instruction is updated.

The invention relates to the technical field of liquid chromatography-mass spectrometry series connection, and particularly discloses a method for detecting folic acid metabolites of red blood cells through the liquid chromatography-mass spectrometry series connection technology. And an image analysis algorithm based on artificial intelligence and deep learning is utilized to extract a chromatographic separation state, so that gradient parameters are dynamically adjusted, the requirement of manual intervention is reduced, and the separation process of a target object in a complex matrix is favorably optimized. Particularly, key features in a chromatogram can be automatically identified and quantified based on a deep learning method, and gradient elution parameters are intelligently and dynamically adjusted according to the information, so that more optimized substance separation and detection can be realized. For example, if separation of a certain component is not ideal, the separation effect of the component can be improved by adjusting the proportion of the mobile phase B, so that the gradient elution process is optimized.

The invention provides a plant lactobacillus KSFY202408 strain and application thereof, and belongs to the technical field of microorganisms. The preservation number of the plant lactobacillus KSFY202408 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No. 31102. The survival rate of the strain in artificial gastric juice with the pH value of 3.0 can reach 55.2%, the survival rate of the strain in artificial gastric juice with the pH value of 2.5 can reach 33.2%, the activity of a helicobacter pylori strain can be remarkably inhibited, formation of a helicobacter pylori thallus biological membrane can be inhibited, and the activity of helicobacter pylori metabolite urease can be reduced. Meanwhile, the bacterial strain can remarkably protect cell membrane integrity and cell viability of gastric mucosa epithelial cells, and has important significance on prevention or treatment of gastritis, gastric ulcer and other digestive tract diseases caused by helicobacter pylori.

Provided in the present invention are compounds shown as formula (I) and racemates, stereoisomers, tautomers, nitrogen oxides, solvates, polymorphs, metabolites, esters, prodrugs or pharmaceutically acceptable salts thereof, which have good p53-Y220C mutant activation effect, can be used for treating tumor diseases containing p53-Y220C mutant proteins, and can be used for preparing drugs for such disorders or diseases.

The invention provides a compound as shown in a formula (I) and a racemate, a stereoisomer, a tautomer, an isotope label, a nitrogen oxide, a solvate, a polymorphic substance, a metabolite, ester, a prodrug or pharmaceutically acceptable salt thereof, which have better BRD4 inhibition and degradation effects as a drug, and can be used for preparing drugs related to BRD4 inhibition and degradation. And preventing and / or treating related diseases. # imgabs0 #