1392results about "Diagnostics using fluorescence emission" patented technology

Methods and system for atrial fibrillation ablations and other cardiac procedures utilizes a cardiac mapping system for navigation and guidance, and includes an additional virtual reality (VR) system and an augmented reality (AR) or mixed reality (MR) system. The Cardiac mapping system utilizes medical images and patient's electrical signals. The virtual reality (VR) system is utilized pre-procedure for visualization and pre-procedure planning. The augmented reality (AR) or mixed reality (MR) system is utilized pre-procedure or intra-procedure. Methods and system are disclosed utilizing pre-built virtual device models which interact with 3D volume rendered structures from patient's CT or MRI of the region of interest (ROI) for the different type of cardiac procedure. With virtual reality (VR) the operator utilizes hand-held sensors. With augmented reality (AR) or mixed reality (MR) a combination of hand gestures and an X-box controller is used to manipulate virtual devices, anatomical structures in the Hologram.

The present disclosure relates to a line-scanning based super-resolution imaging method and apparatus. A line-scanning based super-resolution imaging method includes: providing a plurality of line-type structured excitation lights, each of the plurality of line-type structured excitation lights having a different illumination pattern; illuminating a target area in a line-by-line scanning manner along a single first direction while switching the plurality of line-type structured excitation lights, such that each row in the target area is illuminated by a corresponding one of the plurality of line-type structured excitation lights; and detecting response light generated by each row in the target area in response to being illuminated by the corresponding one of the plurality of line-type structured excitation lights.

A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

The invention relates to the field of medical information monitoring, and discloses a doctor monitoring bracelet for receiving infusion information of a patient, comprising: a multispectral sensing module for collecting an original physiological light intensity signal of the wrist of the patient; the motion sensing module is used for collecting motion signals; the micro-electro-mechanical motion compensation module is configured on the multispectral sensing module; the processor is electrically connected with the multispectral sensing module, the motion sensing module and the micro-electro-mechanical motion compensation module; and the communication module is electrically connected with the processor. By integrating a high-sensitivity multispectral sensing module and a micro-electro-mechanical active motion compensation system and combining an advanced signal processing algorithm, the accuracy of real-time monitoring of key vital signs of a patient in a complex infusion scene is remarkably improved, more reliable patient infusion information is provided for a subsequent multi-head infusion intelligent switching control system, and the infusion safety of the patient is improved. High fidelity of a data source is ensured, and tedious work of medical staff is reduced.

Disclosed are approaches that may provide image-guidance to interventionalists by providing true 3D visualization and quantitative feedback in real-time. A guidance system may allow a physician to manipulate a medical device and see a 3D rendering with quantitative feedback floating in mixed reality, next to standard monitors. Image tracking may detect and co-register the medical device's 3D position using, for example, bi-plane C-arm X-ray fluoroscopy and provide a 3D trajectory as quantitative feedback. Patterns in a fluoroscopic image may be used to accurately determine an object's z-position from a single angle projection.

Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. The distal tip region may include a bumper tip member, a radiopaque member, and a sleeve disposed over and coupling the bumper tip member and the radiopaque member. An imaging core may be disposed within the catheter shaft.

The present disclosure provides systems, devices, and methods for imaging and imaging subject. The systems and devices may include one or more light filtering devices. The light filtering devices may include a chamber having an input and an output. The chamber may be configured to receive a beam of light. The chamber may comprise a plurality of reflectors configured to direct the light received in an optical path from the input to the output via reflectance of the light between one or more reflectors of the plurality of reflectors. The chamber may be configured to reject out of focus light along the optical path.

Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. A bumper tip member may be disposed along the distal tip region. A marker member may be disposed adjacent to the bumper tip member. The marker member may include an inner layer, a tie layer, and an outer layer including a radiopaque material. A sleeve may be disposed over and couple the bumper tip member and the marker member. An imaging core may be disposed within the catheter shaft.

The invention relates to an apparatus (1) and method for automatically determining the blood flow direction (42) in a blood vessel (14) using the fluorescence light from a fluorophore (16). Blood flow direction (42) is determined by first identifying a blood vessel structure (38) in an input frame (6) from a camera assembly (2) using a pattern recognition module (26). Blood flow direction (42) is determined from the spatial gradient (dl / dx) of the fluorescence intensity (I) along the identified blood vessel structure (38) and the temporal gradient (dl / dt). An output frame (48) is displayed on a display (36) with time-varying marker data (52) overlaid on the identified blood vessels structure (38) and representative of the blood flow direction (42).

A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

The present discloses systems and methods for tissue analysis, biopsy, and treatment utilizing at least exogenous fluorophores and near infrared light. A method is disclosed for optically determining the presence of abnormal cells, such as cancer, in tissue. The method includes applying one or more exogenous fluorophores into tissue in an animal body, wherein the exogenous fluorophores include a targeting moiety formulated to bond with a selected site on abnormal cells. The method includes illuminating the one or more exogenous fluorophores in the tissue with near infrared light from an elongated optical probe to generate fluorescent light from exogenous fluorophores present in the tissue. The method includes receiving fluorescent light generated from the one or more exogenous fluorophores in the tissue. The method includes determining if abnormal cells are present in the tissue based on the fluorescent light generated from the one or more exogenous fluorophores in the tissue.

A muscle probe is provided for obtaining electromyography data and optical spectroscopy data from muscle tissue. The muscle probe comprises an elongate needle having an outer wall surrounding a needle interior, the needle interior comprising: a core electromyography electrode; and one or more optical fibres; wherein the needle is arranged to be inserted into a muscle, and further arranged to detect electrical activity from the muscle; and wherein the one or more optical fibres are arranged to direct incident light from a light source toward a target area of the muscle, and further arranged to receive scattered light from the target area. The present disclosure aims to provide a muscle probe to improve the diagnostic pathway for patients with neuromuscular disorders, by developing a minimally invasive bedside test of muscle health.

A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

The invention discloses an ultra-wide-spectrum endoscopic imaging device capable of being used for short-wave infrared fluorescence imaging, which is used for in-vivo minimally invasive imaging and comprises an illumination module, a wide-spectrum image transmission module, an imaging module and an image processing module. The illumination module consists of a light source and a light guide optical fiber, and is used for generating illumination light from ultraviolet to short wave infrared band and transmitting the illumination light to the wide-spectrum image transmission module; the wide-spectrum image transmission module consists of a few-interface optical imaging channel and a light guide illumination channel, and is used for illuminating an imaging target, exciting target fluorescence and collecting image signals from ultraviolet to short-wave infrared bands; the imaging module is composed of an optical filter and an imaging camera, and the imaging camera can be a wide spectral response image sensor or can be formed by combining cameras working in different wavebands and is used for converting optical images in different wavebands into image data; and the image processing module is used for registering and fusing image data of different wavebands in real time and displaying the image data.

The invention relates to the technical field of medical instruments, and discloses a breast cancer sentinel lymph node positioning system and method, and the system comprises a data collection subsystem, a space positioning subsystem and a central processing subsystem. The method comprises the following steps: acquiring an anatomical structure image, a radioactivity counting rate and fluorescence intensity after performing primary fluorescence, radioactivity and secondary pulse type fluorescence tracer injection in sequence; establishing a global coordinate system and generating an anatomical region of interest; constructing a weighted directed topological graph based on the initial fluorescence data, and obtaining a baseline flow velocity; extracting radionuclide dynamic characteristics based on the radioactive data; a functional flow rate attenuation coefficient is calculated based on the second pulsed fluorescence data. And a multi-factor scoring model is applied, topological information, dynamic characteristics and functional flow velocity attenuation coefficients are fused, and a comprehensive score is calculated to identify the sentinel lymph node. According to the method, the lymphatic flow topological structure, nuclide dynamics and functional flow velocity information are combined, and the positioning accuracy and reliability are improved.

The invention relates to the field of neuroscience experiments, and discloses a method for accurately adjusting the precision of targeted light and calibrating neuron sampling images, which comprises the following steps of: 1, acquiring image data containing neuron activity information; step 2, preprocessing the image data to remove artifact noise; step 3, modeling the deformation of the nervous tissue based on the image data; step 4, regulating and controlling optical system parameters for targeted light stimulation according to a deformation modeling result; and 5, closed-loop updating is performed on the modeling result and the regulation and control parameters based on feedback image data, the image data in the step 1 comprises a calcium imaging image and a targeted light feedback image which are synchronously acquired, the calcium imaging image is used for reflecting neuron activity, and the targeted light feedback image is used for calibrating a light spot position. By adopting an accurate calcium imaging technology and a targeted light feedback image synchronous acquisition scheme, real-time synchronization of neuron activity and light spot position is realized.

The invention relates to the technical field of wound nursing, and discloses a wound flora monitoring method and system. The method comprises the following steps: acquiring wound physiological characteristic parameters, real-time flora monitoring data and multispectral imaging data, and constructing a three-dimensional flora distribution model and an initial flora dynamic model after preprocessing; applying metabolism and environmental conditions to obtain a comprehensive model and flora dynamic coupling data; training a flora classification model to obtain abnormal characteristic parameters; simulating abnormal evolution of flora to obtain information such as diffusion trend; constructing an optimization model to determine the optimal configuration of the monitoring device; and adjusting a monitoring strategy based on the risk grading model. The system comprises a data acquisition module, a model construction and analysis module, a flora classification module, a simulation analysis module, a configuration optimization module and a risk regulation module. Through multispectral imaging, dynamic modeling and an intelligent algorithm, accurate monitoring and risk regulation and control of wound flora are achieved, infection early warning timeliness and monitoring efficiency are improved, and the method is suitable for clinical wound nursing.

A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

Example systems and techniques are disclosed that may determine at least one treatment strategy for a lesion. An example system may include memory configured to store clinical guidance and / or informatics for a PCI procedure and processing circuitry communicatively coupled to the memory. The processing circuitry may be configured to determine the plurality of treatment pathways. The processing circuitry may be configured to obtain angiogram imaging data of a coronary vasculature of a patient. The 2024 / 058837 processing circuitry may be configured to determine the clinical guidance and / or informatics based at least in part on the angiogram imaging data. The processing circuitry may be configured to output for display the angiogram imaging data and at least a portion of the clinical guidance and / or informatics, wherein the at least a portion of the clinical guidance and / or informatics is overlaid onto the angiogram imaging data.

Disclosed are systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. A computer implemented method for detecting (and / or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, includes: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and / or controlled duration between subsequent boluses, analyzing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

The present disclosure provides systems and methods for monitoring an analyte present in a biological sample of a subject by using: a piercing element coupled to a support, the piercing element configured to pierce a body surface of the subject; an analyte binding probe on or inside the piercing element to provide a change in an optical signal upon contact with an analyte in a biological sample of the subject; and a detector configured to detect the light signal.

A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.

The invention discloses a fluorescence diffusion tomography method and system based on full-angle line scanning excitation, and relates to the technical field of optical and biomedical engineering, an excitation scanning module and a detection module are designed, a near-infrared light beam can be generated, the near-infrared light beam is focused on the surface of a to-be-detected sample to form a diffusible line light source, and the diffusible line light source is focused on the surface of the to-be-detected sample; therefore, line scanning excitation is realized. A forward process modeling method is designed, field intensity distribution of linear light source diffusion is regarded as weighted accumulation of field intensity distribution of discrete point light source diffusion, and a system forward matrix is obtained. A system calibration method is designed, the spatial position of the linear beam under different biaxial galvanometer voltage values is calibrated by means of a steel bar, and determination of space coordinates of starting points at the two ends of the linear beam and determination of the relation between the deflection angle of the linear beam and the biaxial galvanometer voltage are achieved. According to the method, the FDT imaging speed is remarkably increased while the reconstruction precision is guaranteed, and further application and expansion of the FDT technology in the fields such as dynamic imaging and the like with high real-time performance requirements are assisted.

A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.

The present disclosure relates to techniques for imaging tissue of a subject. An exemplary method comprises transitioning a (liquid crystal) light shutter to an open state to allow reflected light from illuminating the tissue of the subject with a visible-light illumination source to accumulate charge at a plurality of rows of pixels of an imager; transitioning the light shutter to a closed state to prevent the imager from receiving visible light; during a first readout period, reading accumulated charge to produce a first set of imaging data; while the light shutter is in the closed state, illuminating the tissue of the subject with a fluorescence excitation illumination source; during a second readout period after the first readout period, reading accumulated charge to produce a second set of imaging data; and generating image frames based on the first set of imaging data and the second set of imaging data.

The invention discloses a laser depilation dynamic parameter adjustment method based on skin typing recognition, and relates to the technical field of laser depilation, and the method comprises the steps: constructing a three-dimensional skin model of a depilation region through multi-dimensional data cross validation; detecting local pigmentation caused by friction in each area; detecting the blood flow signal intensity of capillary vessels around the hair follicles, judging the period of the hair and generating a hair follicle activity thermodynamic diagram in real time; a three-dimensional energy focus is formed through double-beam crossing; skin curved surface data are obtained through a pressure sensor, liquid crystal molecules in a light valve are driven to be arranged, and light spots are adjusted to be in the shape attached to an unhairing area; the basal metabolic rate of the patient is measured through a noninvasive bioelectrical impedance analysis technology, and the energy density is adjusted based on the basal metabolic rate; and establishing a digital twinborn model, and integrating depilation data, skin state and hormone level information. A three-dimensional energy focus is formed through double-beam crossing, energy is accurately focused on the root of the hair follicle, and epidermis damage is avoided.

A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

Provided herein are methods of treating a cancer in a subject, wherein the cancer expresses a Ro52 antigen, comprising administering an anti-Ro52 binding agent to the subject, thereby treating the cancer in the subject. In some embodiments, the Ro52 antigen is expressed on a cancer cell surface. In some embodiments, the anti-Ro52 binding agent comprises a Fab, Fab', F(ab')2, Fahl-SH, Fv, diabody, linear antibody or single-chain variable fragment (scFv). In some embodiments, the anti-Ro52 binding agent is a humanized or chimeric antibody. In some embodiments, the anti-Ro52 binding agent is conjugated to a therapeutic agent.

An apparatus for carbon dioxide monitoring is disclosed that includes a photoluminescent carbon dioxide sensitive probe with a polymer matrix and a sensing dye, a photon source configured to send photons to the probe, a photodetector configured to detect light emitted from the probe when the photon source sends photons to the probe, a carbon dioxide permeable light redirecting layer, the carbon dioxide sensitive probe disposed between the light redirecting layer and the photodetector, and a controller in electrical communication with the photon source and the photodetector, the controller configured to execute a program for calculating a level of carbon dioxide adjacent the probe from an electrical signal received from the photodetector, the program being stored in the controller. In one form, the polymer matrix includes a polymer selected from the group consisting of acrylate polymers, methacrylate polymers, polyurethane polymers, and blends and copolymers thereof.