1939results about "Diagnostics using fluorescence emission" patented technology

An illustrative method may include receiving images of a site captured at a same time by a camera, the images comprising a single visible color component image, a first non-visible image associated with first excitation illumination having a first wavelength outside a visible spectrum, and a second non-visible image associated with second excitation illumination having a second wavelength outside the visible spectrum and different than the first wavelength; generating, based on the single visible color component image, a monochromatic image; generating, based on the single visible color component image and the first non-visible image, a first alternate image representative of a first alternate imaging characteristic of the site; generating, based on the single visible color component image and the second non-visible image, a second alternate image representative of a second alternate imaging characteristic of the site; and displaying the monochromatic image combined with the first and second alternate images.

A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.

The invention provides a fluorescence imaging method and device based on light source intensity adjustment and a storage medium, and the method comprises the steps: in a PDD fluorescence mode, when a blue light source is turned on, after blue light is reflected by an observation tissue, filtering a spectrum of a green fluorescence wave band generated by excitation of riboflavin through a notch filter; in the photodynamic white light image mode, red light, green light and blue light emitted by the red light source, the green light source and the blue light source are adjusted through the light compensation module according to preset light power, so that the light is reflected by observation tissue and then passes through the notch filter to be white light, and the light compensation module controls the light power output by the red light source and the light power output by the blue light source to be consistent. The green light output power is higher than the light power of the red light or blue light. By combining the notch filter and the light compensation module, the problem that in the PDD fluorescence imaging process, green fluorescence generated by excitation of riboflavin affects the contrast ratio of PDD fluorescence imaging is solved, and meanwhile color rendition of traditional white light imaging can be guaranteed.

Methods and system for atrial fibrillation ablations and other cardiac procedures utilizes a cardiac mapping system for navigation and guidance, and includes an additional virtual reality (VR) system and an augmented reality (AR) or mixed reality (MR) system. The Cardiac mapping system utilizes medical images and patient's electrical signals. The virtual reality (VR) system is utilized pre-procedure for visualization and pre-procedure planning. The augmented reality (AR) or mixed reality (MR) system is utilized pre-procedure or intra-procedure. Methods and system are disclosed utilizing pre-built virtual device models which interact with 3D volume rendered structures from patient's CT or MRI of the region of interest (ROI) for the different type of cardiac procedure. With virtual reality (VR) the operator utilizes hand-held sensors. With augmented reality (AR) or mixed reality (MR) a combination of hand gestures and an X-box controller is used to manipulate virtual devices, anatomical structures in the Hologram.

The invention provides a fluorescence imaging method suitable for bladder photodynamic diagnosis, and the method comprises the following steps: in a PDD fluorescence mode, when a blue light source is turned on, blue light is reflected by observation tissues, and a spectrum of a green fluorescence wave band generated by excitation of riboflavin is filtered through a notch filter so as to reduce interference of green fluorescence on PDD fluorescence contrast; in the photodynamic white light image mode, when the red light source, the green light source and the blue light source are turned on at the same time, after light is reflected by observation tissue, green fluorescence wave band spectrums are absorbed through the notch filter, illumination light of the green fluorescence wave band is enhanced through the light compensation module, and the light passing through the notch filter is white light. By combining the notch filter and the light compensation module, the problem that in the PDD fluorescence imaging process, green fluorescence generated by excitation of riboflavin affects the contrast ratio of PDD fluorescence imaging is solved, and meanwhile color rendition of white light imaging can be guaranteed.

The present disclosure relates to a line-scanning based super-resolution imaging method and apparatus. A line-scanning based super-resolution imaging method includes: providing a plurality of line-type structured excitation lights, each of the plurality of line-type structured excitation lights having a different illumination pattern; illuminating a target area in a line-by-line scanning manner along a single first direction while switching the plurality of line-type structured excitation lights, such that each row in the target area is illuminated by a corresponding one of the plurality of line-type structured excitation lights; and detecting response light generated by each row in the target area in response to being illuminated by the corresponding one of the plurality of line-type structured excitation lights.

According to the imaging equipment based on multi-photon depth imaging provided by the invention, a miniaturized imaging probe is realized by adopting a split type structure. In the imaging process, the imaging probe can be fixedly connected with an imaging object, the multi-photon effect is excited in the imaging object through the exciting light, so that optical signals in the imaging object are collected, and the internal situation in the imaging object is detected. Particularly, in the imaging equipment provided by the invention, the input optical fiber for connecting the imaging probe and the imaging host has the target bandwidth meeting the excitation requirement of the multi-photon effect, so that the composite laser in the target bandwidth can be carried, the multi-photon effects under different wavelengths can be excited at the same time, and different internal structures can be observed. In addition, a laser coupling module is arranged outside the imaging probe by the imaging equipment, so that the composite laser is directly transmitted through the input optical fiber, and the integration level of the imaging probe is improved.

The present disclosure provides methods and systems for identifying a tissue characteristic in a subject. Identifying a tissue characteristic may comprise accessing a database comprising a first set of data from a first image obtained from a first tissue region of the subject and a second set of data from a second image obtained from a second tissue region of the subject; computer processing the first set of data and the second set of data to (i) identify a presence or absence of one or more features indicative of the tissue characteristic in the first image, and (ii) classify the subject as being positive or negative for the tissue characteristic based on the presence or absence of the one or more features in the first image; and generating an electronic report which is indicative of the subject being positive or negative for the tissue characteristic.

A vascular access device (VAD) monitoring system includes a VAD with a catheter tube that is subcutaneously disposed and incorporates a fluorescent dye. An optical imaging system is also provided, comprising a light source emitting infrared (IR) excitation light and a camera capable of detecting signal light emitted by the fluorescent dye upon exposure to the excitation light. This enables real-time monitoring of the VAD, allowing for the detection of any potential complications or issues related to the vascular access device. The combination of the catheter tube with the fluorescent dye and the optical imaging system provides a non-invasive and efficient means of monitoring the VAD, enhancing patient safety and improving overall healthcare outcomes.

A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

The invention relates to the field of medical information monitoring, and discloses a doctor monitoring bracelet for receiving infusion information of a patient, comprising: a multispectral sensing module for collecting an original physiological light intensity signal of the wrist of the patient; the motion sensing module is used for collecting motion signals; the micro-electro-mechanical motion compensation module is configured on the multispectral sensing module; the processor is electrically connected with the multispectral sensing module, the motion sensing module and the micro-electro-mechanical motion compensation module; and the communication module is electrically connected with the processor. By integrating a high-sensitivity multispectral sensing module and a micro-electro-mechanical active motion compensation system and combining an advanced signal processing algorithm, the accuracy of real-time monitoring of key vital signs of a patient in a complex infusion scene is remarkably improved, more reliable patient infusion information is provided for a subsequent multi-head infusion intelligent switching control system, and the infusion safety of the patient is improved. High fidelity of a data source is ensured, and tedious work of medical staff is reduced.

Disclosed are approaches that may provide image-guidance to interventionalists by providing true 3D visualization and quantitative feedback in real-time. A guidance system may allow a physician to manipulate a medical device and see a 3D rendering with quantitative feedback floating in mixed reality, next to standard monitors. Image tracking may detect and co-register the medical device's 3D position using, for example, bi-plane C-arm X-ray fluoroscopy and provide a 3D trajectory as quantitative feedback. Patterns in a fluoroscopic image may be used to accurately determine an object's z-position from a single angle projection.

Preferred embodiments relate to devices and methods for performing a lymphovenous bypass procedure. A coupling element is secured to tissue connected to at least one lymphatic channel of a patient and a vein or artery of the patient. An end of the lymphatic channel that extends through the coupling element is inserted into an open end of the vein or artery to deliver lymph fluid from the lymphatic channel into the vein or artery.

Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. The distal tip region may include a bumper tip member, a radiopaque member, and a sleeve disposed over and coupling the bumper tip member and the radiopaque member. An imaging core may be disposed within the catheter shaft.

The present disclosure provides systems, devices, and methods for imaging and imaging subject. The systems and devices may include one or more light filtering devices. The light filtering devices may include a chamber having an input and an output. The chamber may be configured to receive a beam of light. The chamber may comprise a plurality of reflectors configured to direct the light received in an optical path from the input to the output via reflectance of the light between one or more reflectors of the plurality of reflectors. The chamber may be configured to reject out of focus light along the optical path.

A heart beat detection device comprises at least one optical reflection sensor to be positioned on the skin of a person. The sensor unit is provided with a light emitter and a corresponding light receiver which converts the light reflected by the skin into an electric signal and comprises electrically adjustable optical filters connected to the emitter, to the receiver or to both of them in order to select, upon operation, a desired light wavelength and perform processing of the signals thus obtained in order to reinforce the heart beat signal. A system with this device and a detection method are also described.

Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. A bumper tip member may be disposed along the distal tip region. A marker member may be disposed adjacent to the bumper tip member. The marker member may include an inner layer, a tie layer, and an outer layer including a radiopaque material. A sleeve may be disposed over and couple the bumper tip member and the marker member. An imaging core may be disposed within the catheter shaft.

Aspects of the disclosure relate to the use of an optical detection scheme enabling multiple imaging sub-systems concurrently optimized for retrieving multiple characterization modalities. The feature described is an offset illumination and detection arrangement for a multimodal imaging probe. The imaging probe comprises multiple waveguides disposed within a torque-transfer coil, distally terminating at longitudinally separated positions. A first waveguide may have focusing optics for focused illumination and / or detection. Any number of other waveguides may be deployed for illumination and / or detection having no focusing optics. The disclosure enables high-fidelity multimodal imaging systems.

The invention provides a fluorescence imaging method and device based on light source proportion adjustment and a storage medium, and the method comprises the steps: in a photodynamic diagnosis PDD fluorescence mode, when a blue light source is turned on, after blue light is reflected by tissues, filtering the spectrum of a green fluorescence wave band generated by excitation of riboflavin through a notch filter, the interference of green fluorescence on PDD fluorescence contrast is reduced; in the photodynamic white light image mode, red light, green light and blue light are controlled to be imaged in a stroboscopic mode through the light compensation module, and the proportion of the light power of the red light, the green light and the blue light is controlled, so that the red light, the green light and the blue light are reflected by observation tissue, penetrate through the notch filter and then are synthesized into white light. By combining the notch filter and the light compensation module, the problem that in the PDD fluorescence imaging process, green fluorescence generated by excitation of riboflavin affects the contrast ratio of PDD fluorescence imaging is solved, and meanwhile color rendition of traditional white light imaging can be guaranteed.

The invention provides a fluorescence imaging method and device based on light source pass filtering and a storage medium, and the method comprises the steps: in a PDD fluorescence mode, when a blue light source is turned on, after blue light is reflected by an observation tissue, filtering a green fluorescence wave band spectrum generated by excitation of riboflavin through a notch filter, the interference of green fluorescence on PDD fluorescence contrast is reduced; in a photodynamic white light image mode, when a white light source is turned on, white light firstly passes through a band-pass filter to increase the proportion of a green fluorescence wave band spectrum to a red and blue fluorescence wave band spectrum, then the green fluorescence wave band spectrum is filtered through a notch filter, the notch filter reduces the proportion of the green fluorescence wave band spectrum, and then the red and blue fluorescence wave band spectrum is filtered out. And the difference value of the proportion of the green fluorescence wave band spectrum increased by the band-pass optical filter is within a preset range. The problem that in the PDD fluorescence imaging process, green fluorescence generated by excitation of riboflavin influences the contrast ratio of PDD fluorescence imaging is solved, and meanwhile color rendition of traditional white light imaging can be guaranteed.

The invention provides imaging equipment based on multi-photon depth imaging and an imaging probe thereof, and a miniaturized imaging probe is realized by adopting a split type structure. In the imaging process, the imaging probe can be fixedly connected with an imaging object, the multi-photon effect is excited in the imaging object through the exciting light, so that optical signals in the imaging object are collected, and the internal situation in the imaging object is detected. Particularly, a plurality of input optical fibers are arranged in the imaging probe, laser of multiple wavelengths is provided at the same time in the multi-photon imaging process, optical signals can comprise optical signal components responding to exciting light of different wavelengths at the same time, and different internal structures are excited and detected at the same time. Besides, in the probe, the laser of each wavelength is subjected to beam combination treatment through the coupling module to form composite laser, so that the subsequent treatment of the composite laser is similar to that of exciting light, and the internal structure of the imaging probe is further simplified.

A computer-implemented method for detecting dental plaque on a digital 3D model (101) of a dental situation is disclosed. The method comprises receiving, by a processor, at least a part of the digital 3D model (101) of the dental situation, wherein the at least part of the digital 3D model (101) comprises fluorescence information associated with fluorescence emitted from dental plaque present on teeth of the dental situation. The fluorescence information comprises a red (R) fluorescence signal value and a green (G) fluorescence signal value of at least one unit element of the at least part of the digital 3D model (101). Further, the method comprises detecting a dental plaque parameter (301) on the at least part of the digital 3D model (101) based on the fluorescence information, wherein the dental plaque parameter (301) represents pathogenic plaque present on teeth of the dental situation. Detecting the dental plaque parameter (301) comprises computing a function of the red (R) fluorescence signal value and the green (G) fluorescence signal value for the at least one unit element of the at least part of the digital 3D model (101). Additionally, the method comprises displaying the at least part of the digital 3D model and the detected dental plaque parameter (301).

The present disclosure relates generally to medical imaging, and more specifically to techniques for identifying at least one lymph node of a subject using fluorescence images. An exemplary method comprises obtaining a fluorescence image of a field of view including the at least one lymph node of the subject; obtaining a template image; comparing the template image with the fluorescence image to obtain one or more similarity values; and identifying at least one portion of the fluorescence image that corresponds to a location of the at least one lymph node based on the one or more similarity values.

The invention relates to an apparatus (1) and method for automatically determining the blood flow direction (42) in a blood vessel (14) using the fluorescence light from a fluorophore (16). Blood flow direction (42) is determined by first identifying a blood vessel structure (38) in an input frame (6) from a camera assembly (2) using a pattern recognition module (26). Blood flow direction (42) is determined from the spatial gradient (dl / dx) of the fluorescence intensity (I) along the identified blood vessel structure (38) and the temporal gradient (dl / dt). An output frame (48) is displayed on a display (36) with time-varying marker data (52) overlaid on the identified blood vessels structure (38) and representative of the blood flow direction (42).

A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

The present discloses systems and methods for tissue analysis, biopsy, and treatment utilizing at least exogenous fluorophores and near infrared light. A method is disclosed for optically determining the presence of abnormal cells, such as cancer, in tissue. The method includes applying one or more exogenous fluorophores into tissue in an animal body, wherein the exogenous fluorophores include a targeting moiety formulated to bond with a selected site on abnormal cells. The method includes illuminating the one or more exogenous fluorophores in the tissue with near infrared light from an elongated optical probe to generate fluorescent light from exogenous fluorophores present in the tissue. The method includes receiving fluorescent light generated from the one or more exogenous fluorophores in the tissue. The method includes determining if abnormal cells are present in the tissue based on the fluorescent light generated from the one or more exogenous fluorophores in the tissue.

A muscle probe is provided for obtaining electromyography data and optical spectroscopy data from muscle tissue. The muscle probe comprises an elongate needle having an outer wall surrounding a needle interior, the needle interior comprising: a core electromyography electrode; and one or more optical fibres; wherein the needle is arranged to be inserted into a muscle, and further arranged to detect electrical activity from the muscle; and wherein the one or more optical fibres are arranged to direct incident light from a light source toward a target area of the muscle, and further arranged to receive scattered light from the target area. The present disclosure aims to provide a muscle probe to improve the diagnostic pathway for patients with neuromuscular disorders, by developing a minimally invasive bedside test of muscle health.

A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

The invention discloses an ultra-wide-spectrum endoscopic imaging device capable of being used for short-wave infrared fluorescence imaging, which is used for in-vivo minimally invasive imaging and comprises an illumination module, a wide-spectrum image transmission module, an imaging module and an image processing module. The illumination module consists of a light source and a light guide optical fiber, and is used for generating illumination light from ultraviolet to short wave infrared band and transmitting the illumination light to the wide-spectrum image transmission module; the wide-spectrum image transmission module consists of a few-interface optical imaging channel and a light guide illumination channel, and is used for illuminating an imaging target, exciting target fluorescence and collecting image signals from ultraviolet to short-wave infrared bands; the imaging module is composed of an optical filter and an imaging camera, and the imaging camera can be a wide spectral response image sensor or can be formed by combining cameras working in different wavebands and is used for converting optical images in different wavebands into image data; and the image processing module is used for registering and fusing image data of different wavebands in real time and displaying the image data.

The invention relates to the technical field of medical instruments, and discloses a breast cancer sentinel lymph node positioning system and method, and the system comprises a data collection subsystem, a space positioning subsystem and a central processing subsystem. The method comprises the following steps: acquiring an anatomical structure image, a radioactivity counting rate and fluorescence intensity after performing primary fluorescence, radioactivity and secondary pulse type fluorescence tracer injection in sequence; establishing a global coordinate system and generating an anatomical region of interest; constructing a weighted directed topological graph based on the initial fluorescence data, and obtaining a baseline flow velocity; extracting radionuclide dynamic characteristics based on the radioactive data; a functional flow rate attenuation coefficient is calculated based on the second pulsed fluorescence data. And a multi-factor scoring model is applied, topological information, dynamic characteristics and functional flow velocity attenuation coefficients are fused, and a comprehensive score is calculated to identify the sentinel lymph node. According to the method, the lymphatic flow topological structure, nuclide dynamics and functional flow velocity information are combined, and the positioning accuracy and reliability are improved.