615results about "Diagnostics using fluorescence emission" patented technology

A neurosurgery system for probing brain tissue of a patient for tumorous tissue. The system including a suction tool, an excitation source, an optical instrument, and a controller. The suction tool including a suction cannula defining a lumen, an optical fiber configured to transmit fluorescence emitted by the brain tissue; and an indicator configured to selectively emit visible light. An excitation source is configured to emit an excitation light having a wavelength to induce the fluorescence in the tumorous tissue. The optical instrument is coupled to the optical fiber. The optical instrument configured to convert the fluorescence emitted by the brain tissue and transmitted by the optical and configured to determine that the brain tissue is tumorous based on the electrical signal and activate the indicator based on the determination.

Disclosed are approaches that may provide image-guidance to interventionalists by providing true 3D visualization and quantitative feedback in real-time. A guidance system may allow a physician to manipulate a medical device and see a 3D rendering with quantitative feedback floating in mixed reality, next to standard monitors. Image tracking may detect and co-register the medical device's 3D position using, for example, bi-plane C-arm X-ray fluoroscopy and provide a 3D trajectory as quantitative feedback. Patterns in a fluoroscopic image may be used to accurately determine an object's z-position from a single angle projection.

A muscle probe is provided for obtaining electromyography data and optical spectroscopy data from muscle tissue. The muscle probe comprises an elongate needle having an outer wall surrounding a needle interior, the needle interior comprising: a core electromyography electrode; and one or more optical fibres; wherein the needle is arranged to be inserted into a muscle, and further arranged to detect electrical activity from the muscle; and wherein the one or more optical fibres are arranged to direct incident light from a light source toward a target area of the muscle, and further arranged to receive scattered light from the target area. The present disclosure aims to provide a muscle probe to improve the diagnostic pathway for patients with neuromuscular disorders, by developing a minimally invasive bedside test of muscle health.

The invention discloses an ultra-wide-spectrum endoscopic imaging device capable of being used for short-wave infrared fluorescence imaging, which is used for in-vivo minimally invasive imaging and comprises an illumination module, a wide-spectrum image transmission module, an imaging module and an image processing module. The illumination module consists of a light source and a light guide optical fiber, and is used for generating illumination light from ultraviolet to short wave infrared band and transmitting the illumination light to the wide-spectrum image transmission module; the wide-spectrum image transmission module consists of a few-interface optical imaging channel and a light guide illumination channel, and is used for illuminating an imaging target, exciting target fluorescence and collecting image signals from ultraviolet to short-wave infrared bands; the imaging module is composed of an optical filter and an imaging camera, and the imaging camera can be a wide spectral response image sensor or can be formed by combining cameras working in different wavebands and is used for converting optical images in different wavebands into image data; and the image processing module is used for registering and fusing image data of different wavebands in real time and displaying the image data.

The invention relates to the technical field of medical instruments, and discloses a breast cancer sentinel lymph node positioning system and method, and the system comprises a data collection subsystem, a space positioning subsystem and a central processing subsystem. The method comprises the following steps: acquiring an anatomical structure image, a radioactivity counting rate and fluorescence intensity after performing primary fluorescence, radioactivity and secondary pulse type fluorescence tracer injection in sequence; establishing a global coordinate system and generating an anatomical region of interest; constructing a weighted directed topological graph based on the initial fluorescence data, and obtaining a baseline flow velocity; extracting radionuclide dynamic characteristics based on the radioactive data; a functional flow rate attenuation coefficient is calculated based on the second pulsed fluorescence data. And a multi-factor scoring model is applied, topological information, dynamic characteristics and functional flow velocity attenuation coefficients are fused, and a comprehensive score is calculated to identify the sentinel lymph node. According to the method, the lymphatic flow topological structure, nuclide dynamics and functional flow velocity information are combined, and the positioning accuracy and reliability are improved.

Example systems and techniques are disclosed that may determine at least one treatment strategy for a lesion. An example system may include memory configured to store clinical guidance and / or informatics for a PCI procedure and processing circuitry communicatively coupled to the memory. The processing circuitry may be configured to determine the plurality of treatment pathways. The processing circuitry may be configured to obtain angiogram imaging data of a coronary vasculature of a patient. The 2024 / 058837 processing circuitry may be configured to determine the clinical guidance and / or informatics based at least in part on the angiogram imaging data. The processing circuitry may be configured to output for display the angiogram imaging data and at least a portion of the clinical guidance and / or informatics, wherein the at least a portion of the clinical guidance and / or informatics is overlaid onto the angiogram imaging data.

The invention relates to the technical field of skin lesion area reconstruction, in particular to a skin lesion area reconstruction system based on multi-modal image fusion. The system comprises a deep multi-scale feature extraction module, a skin thermal anomaly feature extraction module, a hemodynamic feature extraction module, a depth and boundary feature extraction module, a skin surface feature extraction module, a fluorescence intensity distribution and morphological feature extraction module, a first feature fusion module, a second feature fusion module and a lesion area reconstruction module. According to the method, appearance, heat, blood flow, structure and surface features are extracted from the multi-modal data, then the multi-modal image data are integrated, finally, comprehensive representation and reconstruction of skin lesion appearance, function and structure information are achieved according to the synergistic effect of the multi-modal information, and the accuracy and clinical reference value of lesion area reconstruction are effectively improved.

The present disclosure relates to techniques for imaging tissue of a subject. An exemplary method comprises transitioning the liquid crystal light shutter to the closed state to prevent the global shutter imager from receiving visible light; illuminating the tissue of the subject with the fluorescence excitation illumination source to accumulate charge at a plurality of pixels of the global shutter imager, while the liquid crystal light shutter is in the closed state; reading a set of accumulated charge at the plurality of pixels of the global shutter imager to produce a set of imaging data; and generating a fluorescence image frame based on the set of imaging data.

A method of medical multi-dye fluorescence imaging. The method including: capturing fluorescent images of an operating field in which two or more different fluorescent dyes are present in successive sequences of images with a surgical or diagnostic imaging device, each sequence of images alternating through different modes of excitation lighting adapted for at least one each of two or more of the two or more different dyes, and processing the captured images of each successive sequence of images in combination with each other. The processing comprising determining the respective local distributions of the two or more different fluorescence dyes causing the observed different distributions of brightness in the two or more different fluorescent images of the sequence and producing one or more images displaying the determined local distributions of the two or more different fluorescent dyes separately.

Proposed is a method, apparatus, and system for providing medical diagnosis assistance information showing whether a tissue related to a tissue image is normal or abnormal (e.g., cancer) using the AI technology. Proposed are a method, an apparatus, and a system for training an AI model for producing medical diagnosis assistance information in consideration of conditions for obtaining a tissue image in an endomicroscope system for digital biopsy.

An image processing apparatus includes, among other things, a control unit that adjusts luminance of a first image and luminance of a second image by adjusting a first control parameter for controlling at least one of a first light source, a first imaging unit, or a first image processing unit and a second control parameter for controlling at least one of a second light source, a second imaging unit, or a second image processing unit on the basis of luminance information of the superimposed image.

An implantable multi-photon optical probe includes a probe housing having a proximal end and a distal end implantable on a sample. The probe housing adapted to provide excitation energy to the sample and to collect emitted radiation from the sample. The probe housing includes scanning optics configured to receive excitation radiation, and to laterally and axially scan the excitation radiation over a field-of-view of the optical probe. A scanning lens is disposed in the probe housing configured to receive the excitation radiation from the scanning optics, and an objective lens reshapes and focuses the excitation radiation. A focusing lens is disposed to receive the excitation radiation and to focus the excitation radiation into the sample.

The invention provides a dysphagia screening system based on computer vision, and relates to the technical field of image recognition, and the system comprises an image collection module which collects image data of a swallowing event to obtain a time sequence image sequence; the motion field establishing module is used for extracting a motion point track sequence according to the time sequence image sequence and establishing a global motion transformation field; the motion separation module is used for carrying out registration correction on the global motion transformation field and carrying out motion separation on the stabilized image sequence to obtain local deformation components; the region segmentation module is used for carrying out key region segmentation on the local deformation components to obtain swallowing function parameters; and the risk identification module is used for identifying the obstacle risk of the swallowing function parameters and generating a swallowing obstacle screening report. According to the method and the device, the technical problem of relatively poor screening accuracy of the dysphagia based on the computer vision in the prior art can be solved, and the technical effect of improving the screening accuracy of the dysphagia based on the computer vision is achieved.

The present disclosure relates to systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. One embodiment relates to a computer implemented method for detecting (and / or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, the method comprising the steps of: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and / or controlled duration between subsequent boluses, analysing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

Method is presented for monitoring time-varying fluorescence. The method includes providing a measurement data set, transforming each Flr signal of each measurement data entry of the measurement data set to an agent intrinsic fluorescent (IF) signal, monitoring the agent IF signal for each measurement data entry within the measurement data set, whereby fluorescence emission of the agent is determined with reduced sensitivity to the time-varying optical properties of the medium.

The invention relates to a three-dimensional fluorescence tomography imaging device, which comprises a shooting part, an image processing part, a plurality of exciting light emitting parts, a tomography light emitting part, a first reflecting mirror, a beam splitter, a second reflecting mirror, a multi-wavelength light source part and a wavelength adjustable light filter, the image processing part calculates the depth corresponding to each fluorescent image according to the depth information in the optical coherence tomography image, and combines each fluorescent image according to the depth to form a three-dimensional fluorescent tomography image of the shooting object corresponding to the first fluorescent developing agent.

The present invention relates in particular to the field of anesthesia and to a method for real-time evaluation of the mean arterial pressure of a patient from plethysmography measurements.

An optical sensor system for detecting a tissue type in a surgical procedure is described. The optical sensor system includes an excitation source configured to selectively emit excitation light, a probe comprising at least one fiber coupled to the excitation source and configured to illuminate target tissue with excitation light and collect light from target tissue, a compliance member coupled to the at least one fiber, the compliance member being at least partially translucent and configured to deform in response to engagement by a surgical tool, an indicator element configured to emit light in response to receiving an indicator signal, an optical detection module coupled to the at least one fiber and configured to generate a signal based on the collected light, and a controller configured to determine a tissue characteristic based on the signal and generate the indicator signal based on the determined tissue characteristic.

The present invention relates to a fluorescence endoscope system, including a light source module, a camera module, a main control module, and a display module. The light source module is configured to emit an illumination beam, the camera module includes an endoscope configured to propagate the illumination beam and its reflected beam, and an operation unit configured to collect the reflected beam and convert the collected reflected beam into video data therefrom. The main control module includes a control unit configured to drive the light source module to emit a first illumination beam or a second illumination beam, and an image processing unit configured to process the video data frame by frame. The display module is configured to play the video data. The present invention can provide at least two operation modes including a white light mode and a fluorescence mode, and a first button of the operation unit can switch between the white light mode and the fluorescence mode, and has the advantage that the fluorescence imaging can provide a fluorescence image of tissue below the tissue surface, and can visualize and accurately identify lesions that are difficult to observe or early lesions, thereby improving the safety of surgery.

The technology described herein can be embodied in a method that includes receiving data representing information captured using a first sensor and a second sensor of a multi-sensor camera. The sensors are configured to capture a surgical scene illuminated by a light source configured to emit wavelengths in the visible spectrum corresponding to sensing capabilities of the first and second sensors, respectively. The method also includes receiving data representing information captured using a third sensor of the multi-sensor camera, the third sensor configured to capture the surgical scene as illuminated by a near-infrared light source, and generating a first visual representation of the surgical scene based on the data representing the information captured using the first and second sensors. The first visual representation is combined with the information captured using the third sensor to generate a second visual representation, and the second visual representation is presented on a display device.

The embodiment relates to a device configured to perform photobiomodulation (PBM) therapy. The device comprises a main body having a light-emitting head and a light source for emitting light through the light-emitting portion of the light-emitting head. The light source is configured to emit light simultaneously at multiple peak wavelengths in order to perform photobiomodulation (PBM) therapy, and the multiple peak wavelengths are within the spectral range of 615 nm to 1100 nm.

Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.

A device for intermittent monitoring of a biomolecule in a human body, and use thereof. The device includes a device casing, a microneedle array including an array of needles configured to extract interstitial fluid from a user, a microfluidic system defining a fluidic channel including a biomolecule debonding agent, wherein the fluidic channel is in fluidic communication with the microneedle array and configured to facilitate flow of the extracted interstitial fluid therethrough, and an assay system in fluidic communication with the microfluidic system. The assay system includes an affinity binding agent capable of generating an indication of a level of one or more biomolecules present in the extracted interstitial fluid. The microneedle array, the microfluidic system, and assay system are disposed within the device casing.

Offset illumination using multiple emitters in a fluorescence imaging system is described. The system includes an emitter to emit pulses of electromagnetic radiation and an image sensor including an array of pixels to sense reflected electromagnetic radiation. The emitter includes a first emitter and a second emitter to emit electromagnetic radiation of different wavelengths. The system causes at least a portion of the pulses of electromagnetic radiation emitted by the emitter to include one or more of a hyperspectral emission, a fluorescence emission, or a laser mapping mode.

The present invention provides: (i) a gene expression construct for expressing a reporter gene in a cell, wherein the reporter gene encodes a fusion protein comprising a transmembrane domain fused in-frame to a reporter domain, wherein the transmembrane domain, upon insertion of the fusion protein into the cell membrane, anchors the fusion protein to the cell membrane and simultaneously expresses the reporter domain on the cell surface; and (ii) a reporter system comprising a radiolabeled reporter peptide, wherein the reporter domain comprises a large polypeptide subunit of a split luciferase and the reporter peptide comprises a small peptide subunit of the split luciferase, and both subunits associate by complementation to form a luciferase complex.

The invention discloses a near-infrared fluorescence imaging agent of a targeted folate receptor, an imaging system and application of the imaging agent and the imaging system, and belongs to the technical field of biomedical treatment. The technical problem to be solved is to provide the folate receptor-targeted near-infrared fluorescence imaging system, an imaging agent in the system can specifically target the folate receptor FR-alpha, and the folate receptor-targeted near-infrared fluorescence imaging system is used in application scenes of lung cancer and ovarian cancer and can show higher TNR, display tumor boundaries in real time and reduce the positive edge cutting rate. According to the technical scheme, the near-infrared fluorescence imaging agent of the targeted folic acid receptor is characterized by comprising a compound of the targeted folic acid receptor, a solvent and pharmaceutically acceptable auxiliary materials, the structure of the compound of the targeted folic acid receptor is F-L-D, F is the structure of the targeted folic acid receptor, D is a near-infrared dye, L is a connexon, and L is an electron donor. The structural formula is shown in the specification or pharmaceutically acceptable salts thereof.

A computer-implemented method for detecting tooth cracks on a digital 3D model (501) of a dental situation is disclosed. The method comprises receiving the digital 3D model (501) of the dental situation, generating an input (301, 401) for a trained neural network (300, 400) for tooth crack detection, wherein the input (301, 401) comprises at least a part of the digital 3D model (501) with associated color information. The method further comprises detecting a tooth crack (100) on the at least part of the digital 3D model (501) by applying the trained neural network (300, 400) to the generated input (301, 401). Further, the method comprises determining a severity level of the detected tooth crack (100) based on fluorescence information associated with the at least part of the digital 3D model (501) and displaying the at least part of the digital 3D model (501), the detected tooth crack (100) and the severity level of the detected tooth crack (100).

A super-resolution imaging method (100) and apparatus based on line scan. The super-resolution imaging method (100) based on line scan includes: providing multiple types of structured line excitation light, each of the multiple types of structured line excitation light having a different illumination mode (step S102); illuminating a target area in a manner of row-by-row scanning along a single first direction while switching the multiple types of structured line excitation light, such that each row in the target area is illuminated by a corresponding type of structured line excitation light among the multiple types of structured line excitation light (step S104); and detecting response light generated by the each row in the target area in response to being illuminated by the corresponding type of structured line excitation light (step S106).

Disclosed herein are viewing systems configured for viewing an image of a biological object illuminated with light and a viewing device (e.g., loupes, glasses, etc.) and methods for operation thereof. The viewing device comprises a plurality of viewing modes: a white light mode, a fluorescent light mode, and an overlay mode, and a shutter that opens and closes in accordance with the viewing mode. An overlay image is an image of the biological object when the biological object is illuminated with both white light and fluorescent light, causing the overlay image to be an overlay of the white light image and the fluorescent light image. The disclosed systems and methods allow a user (e.g., a surgeon, medical staff, etc.) to preserve the ergonomics offered by eyewear while providing fluorescent viewing capabilities, particularly with visible fluorescent dyes.

To provide a catheter set capable of performing safe measurement.SOLUTION: A catheter set includes a catheter 15 and a measurement probe. The catheter 15 includes: an opening part 151 arranged on a tip side; a flow channel 156 arranged between the opening part and a rear end side; and a probe duct 157 arranged in parallel with the flow channel 156. The measurement probe includes a light guide body to be insertable to the probe duct 157. The catheter 15 includes a projection prevention part 159 for preventing the light guide body from projecting from a tip side of the probe duct 157.SELECTED DRAWING: Figure 24