An automated actuator for the spring-based end effector of a medical instrument to be used by a single operator without assistance for biopsy, clipping, clamping, grasping, snaring, cutting, dissecting or other operative functions with electrical connections for cautery or hot biopsy used independently or combined with a rigid or flexible endoscope of any size. The control mechanism may be a spring(s), gear(s), electrical solenoid or motor, air or hydraulic pressure activated piston or a combination thereof. Automated action may be initiated by voice, hand or foot controls. The actuating mechanism may be disposable, attached to or separable from the end effector instrument or permanently attached to be reusable. The automated instrument may be combined with an endoscope.