Medical devices for 
insertion into the body of human or veterinary patients, wherein the device comprises a) a working element (e.g. a wire, a guidewire, a tube, a 
catheter, a cannula, a scope (e.g., rigid or 
flexible endoscope, laparoscope, sigmoidoscope, 
cystoscope, etc.) a probe, an apparatus for collecting information from a location within the body (e.g., an 
electrode, sensor, camera, scope, sample withdrawal apparatus, 
biopsy or 
tissue sampling device, etc.) which has an outer surface and b) a continuous or non-continuous 
coating on the outer surface of the working element. The outer surface of the working element is prepared to create a surface 
topography which promotes mechanical or frictional engagement of the 
coating to the working element. In some embodiments the 
coating is a lubricious coating, such as a 
fluorocarbon coating or a hydrogel that becomes lubricious when contacted by a liquid. In some embodiments, the coating may expand as swell. Also disclosed as methods for manufacturing such devices.