30 results about "Circulatory time" patented technology

A system for reprocessing flexible endoscopes having lumen therein. The reprocessing system deploys steam to disinfect and/or sterilize the endoscopes, and designs, components, and methods for reducing or balancing the reprocessing cycle time and the effects of thermal expansion and contraction on the endoscopes.

Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.

A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle time and increased stability of the lyophilized FVIII.

The invention discloses long-circulating solid lipid docetaxel nanoparticles and a preparation method thereof. The long-circulating solid lipid docetaxel nanoparticles comprise the following materialsin therapeutic effective dose: docetaxel, lipid materials, long-circulating auxiliary materials and an emulsifier. The long-circulating solid lipid docetaxel nanoparticles have small particle size, high encapsulation rate and good stability, and not only improve the solubility and the stability of the docetaxel, reduce the toxicity of the docetaxel, but also prolong the circulating time of a medicament in blood, and improve the therapeutic index of the medicament, so that the preparation has the characteristics of low toxicity, low allergy, high efficiency and targeting in clinical application.

The invention discloses a circulatory time difference detection method for an ultrasonic flow meter. A pair of transducers is used as an emission and receiving signal detection group and arranged on the two sides of a pipe to be detected at certain angle. A detection period comprises controlling the two transducers (A&B) to serve as emission ends simultaneously to emit pulse signals of different frequencies; controlling the two transducers to serve as receiving ends, recording time of the signals used from being emitted by the transducer A to reaching the transducer B and time of the signals from being emitted by the transducer B to reaching the transducer A respectively, calculating time differences, performing calculation for N times continuously, calculating an average time difference (k=1,...,N-n) by taking the time differences from the kth time to the (k+n)th time, and calculating the flow speed and the flow by combining geometrical information. Compared with a traditional time difference method, the detection method has the advantages that the requirement of the time-difference method ultrasonic flow meter for high measuring accuracy can be met on the basis of reduction of the equipment number.

An ultrasonic cleaner is provided with a user interface, display, and a solution timer unit that tracks the amount of time cleaning solution has been in use. The solution life is displayed in hours and minutes that can be adjusted or reset by an operator. The ultrasonic cleaner includes a solution reset key conspicuously located on a control panel that is mounted on a housing of the ultrasonic cleaner. An operator may periodically check how long the solution has been in use by simply looking at a screen displaying the time elapsed since the beginning of the period. The display may also indicate cleaning cycle times and status, such as the completion of a cleaning cycle; and the user interface may allow the operator to set cleaning cycle parameters, such as cleaning cycle time.

The invention discloses a preparation method and an application of an erythrocyte membrane-coated acid-sensitive polymer prodrug nano drug delivery system, wherein the polymer is formed by connecting sodium polyglutamate and carbocisteine through a peptide bond and then is bonded with an anti-cancer drug taxol to form the polymer prodrug; and the polymer prodrug is coated by an erythrocyte membrane to obtain an erythrocyte membrane-coated acid-sensitive polymer drug delivery system. The drug delivery system has the following characteristics that the particle size is about 100nm, and the shape is a sphere; the drug delivery system is relatively stable in a phosphate buffer and serum; the drug release character is relatively good in an acid environment; the toxicity is obviously reduced in cell experiments; the ingestion of the system by macrophage is obviously reduced; without destructive effect on erythrocyte, the system can be applied to intravenous injection; the circulating time of the system in blood is remarkably longer than that of polymer; and the system has an obvious inhibiting effect on the tumor growth of lung cancer.

The invention a bionic acid-sensitive nano drug as well as a preparation method and an application method thereof. The bionic acid-sensitive nano drug comprises an inner core and an outer shell, wherein the outer shell comprises a targeted modified red blood cell membrane. The bionic acid-sensitive nano drug has immune-free natural biological characteristics, and can greatly prolong in-vivo circulating time of the nano drug; and the inner core comprises a carrier with a sensitive bond on a side chain, and can effectively release the drug to achieve the purpose of targeted treatment of tumors.The preparation method for the bionic acid-sensitive nano drug is simple, is suitable for large-scale production, is suitable for preparing the targeted treatment drug, is preferably suitable for preparing the tumor targeted treatment drug, and is especially suitable for preparing a brain glioma targeted treatment drug, and effectively solves the key problems that the existing nano-drug is short in in-vivo circulating time, has difficulty in crossing BBB, is low intake amount by tumor cells, is low in release at a focus, and the like.

A dishwasher that fits within the conventional U.S. residential dishwasher counter space and uses the conventional U.S. residential power supply to achieve within a convenient cycle time the same standard of sanitation as set forth for commercial and residential hot water sanitizing dishwashers.

An apparatus for monitoring biological information is provided. The apparatus includes a detection part configured to detect a signal indicative of the biological information of a subject and a judging part configured to judge the biological information to identify an attribute of the biological information. The apparatus further includes a storage part configured to store the attribute of the biological information together with a time that the attribute is stored and a producing part configured to produce a signal to display the attribute in a chart defined by a first axis representing a cyclic time series and a second axis representing a time series within a cycle of the cyclic time series.

The invention relates to a Tilmicosin lipidosome preparation and a preparation method. The Tilmicosin lipidosome preparation consists of the Tilmicosin lipidosome and the acceptable vector of a medicament; wherein, the Tilmicosin lipidosome contains Tilmicosin, phospholipid and cholesterin with the weight ratio of 1 : 2 to100 : 1 to 15; the acceptable vector of the medicament comprises an internal buffer system, alkali used for regulating pH, and a frozen-dried supporting agent; the adding amount of the frozen-dried supporting agent calculated according to the weight ratio of the phospholipid is as follows: 0.2 to 4 portions of the frozen-dried supporting agent is added into one portion of the phospholipid; the adding amount of the internal buffer system is 5 to 15mL. The invention has the advantages that: the Tilmicosin content in the unit volume of the Tilmicosin lipidosome preparation is high; the envelop rate is high; the stability is good; moreover, the medicament-loading rate is stable. The medicament in the lipidosome is continuously released, thus remarkably improving the concentration of blood medicament and prolonging the circulating time of the medicament in the blood. The Tilmicosin lipidosome preparation improves the curative effect of the medicament and enhances the clinic usability of the medicament.

The invention relates to a cleaning process of a cold-rolled silicon steel acid cleaning system, which is the supplementary of the circulatory system of the total acid cleaning process and cleans the heater and the total system with hot natrium hydroxydatum solution. The invention can heat with self-heating system and adjust the temperature of the cleaning liquid and the circulatory time according to the cleaning effect. The total acid cleaning system can clean according to the actual operation condition; the graphite heater which is clogged easily can be cleaned completely on the line in order to reduce the accident. The invention can improve the operation reliability of the system, which reduces the discharging of the waste water, and doesn't pollute the environment.

A liposome able to pass through blood brain barrier contains the blood brain barrier anchor site (5-15 mol %), the phosphatide with high phase-change temp, cholesterol and fusion aid. A composite medicine using said liposome as carrier for passing through blood brain barrier for treating the diseases in central nerve system and its preparing process are also disclosed.

The invention discloses a press control device of a cardio-pulmonary resuscitation machine and a control method thereof, and the press control device relates to a medical appliance. The device comprises an integrated circuit control unit, a reversing solenoid valve unit and a press unit which are sequentially connected from front to back. The integrated circuit control unit comprises a microcontroller, a power supply circuit and a reset circuit. The method mainly comprises the following steps: determining press air supply time n seconds corresponding to press depth x millimeters according to the relation between the press depth and the press air supply time; determining the circulation time 2i seconds of a press/shrinkage operation according to the press frequency; finishing n-second pressair supply by the reversing solenoid valve unit; downwards moving to the required press depth by the piston; realizing press air discharge by the reversing solenoid valve unit after starting to pressfor i seconds; and returning to a press initial position under the action of a return spring by the piston. Because the press control device has electronic and digital control functions and strong expandability, individualized ordering can be realized according to user demands.

The invention discloses a method for measuring pulmonary circulation time, comprising the following steps of: (1) making chest scout view CT scan and chest conventional CT scan on a testee; according to an obtained chest scanning image, selecting an image the scanning part of which is closest to the heart, showing pulmonary artery and pulmonary vein simultaneously; determining the bed surface position of the image as the scanning position of measuring the pulmonary circulation time of the testee; (2) injecting a contrast agent with a certain concentration into the vein of the testee by a high-pressure injector, and making CT perfusion scan on the scanning position determined by the step 1; (3) after the scan is finished, selecting two images of the contrast agent appearing first in the pulmonary artery and appearing first in the pulmonary vein from obtained images; and calculating the time interval of the two images by scanning time points recorded on each image. The method overcomes the defects of the past art on precision in the aspect of measuring pulmonary circulation time, and meanwhile, the method is simple and feasible and is convenient to operate.

The invention discloses a perfused distal-end artificial blood vessel with a stent and an artificial blood vessel for a descending part of arcus aortae. The perfused distal-end artificial blood vessel with the stent comprises a flexible artificial blood vessel body, a self-expansion metal stent and a first perfusion branch. The self-expansion metal stent is fixed inwardly away from one section of a heart of the flexible artificial blood vessel body. One section, close to the heart, of the flexible artificial blood vessel body does not have the self-expansion metal stent. The first perfusion branch is used for connection and perfusion of extracorporeal circulation and formed in such a manner that the flexible artificial blood vessel body draws close to one section of the heart. The perfused distal-end artificial blood vessel with the stent and the artificial blood vessel for the descending part of arcus aortae have the following beneficial effects: when an aortic arch part coincides to a descending part on the condition of minor hypothermia during aortic dissection, circulatory arrest time is reduced to 1 to 2 min during an operation so that operation risk is greatly reduced; the complication probability caused by an operation is reduced; and detention time and recovery time of ICU for a patient are reduced.

The invention relates to a tumor targeted nano drug loading system with a controlled-release effect and a preparation method thereof, in particular to a method of adopting a nano precipitation method to enable single-wall carbon nanohorn to efficiently load first-class antitumor drug methotrexate (MTX). Polyethylene glycol is used as a solubilizer to modify the single-wall carbon nanohorn (MTX@oxSWNHs) loaded with the drug, so that water solubility and biocompatibility of MTX@oxSWNHs are improved obviously, and the drug loading system has a good controlled-release effect. Transferrin (Tf) is used as a targeting agent, so that the drug loading system has capability of targeted positioning and targeted releasing. Concentration of drug at a focus is increased, and toxic and side effect, on normal cells, of the drug is reduced greatly. The drug loading system has the advantages of being high in drug loading capacity and biocompatibility and capable of prolonging in-vivo circulating time of slightly-soluble antitumor drug, having targeting performance and being capable of improving the treatment effect of the drug.

A hand-attached controlled pulsed vibration device, allowing for transmission of an enhanced massage, allowing full skin-to-skin contact between the hand of the person giving a massage and the skin of the person receiving the massage, by mounting on the back of the hand, with no glove, partial glove, or straps on the palm-side of the hand, and providing for vibration of controllable intensities and cycle times not normally achievable from a small vibrating motor, by controlling the electric power provided to one or more small vibrating motors, such that the operation of one motor or the interactions between two or more motors result in desirable intensities and cycle times of overall vibration.

The invention relates to a method for measuring blood circulation time of kidney by CT tracking and scanning. The time when the blood containing contrast agent appears in renal artery is observed and recorded on a CT tracking and scanning cross section image, and the time when the blood containing the contrast agent first appears in renal artery is recorded. The difference between the former time and the latter is blood circulation time of kidney. The method for measuring blood circulation time of kidney by CT tracking and scanning is noninvasive, including the steps of initially determining the positions of renal artery and renal vein on the cross section; injecting the contrast agent through the vein to display the blood flowing kidney in the image; and observing the image and respectively recording the time when the contrast agent appears in the renal artery on the cross section and the time when the contrast agent appears in the renal vein, wherein the time between the former time and the latter is the time for which blood enters the kidney from the renal artery and flows out of the kidney from the renal vein, namely the blood circulation time of kidney.

The invention relates to a GLP-1 derivative particle compound and a preparation method thereof, as well as an application thereof in preparation for medicines for treating diabetes and weight-reducing medicines. The compound is a composite system with a core-shell structure, which is formed by entrapping GLP-1 derivative aGLP-1 or mGLP-1 in particles formed by modified polymer gamma-PGA-L-PAE. The particles of the compound disclosed by the invention are capable of stably existing in a solution, and capable of resisting degradation of a PPIV enzyme on the GLP-1 derivative, thus prolonging the systemic circulation time; the particles of the compound have a controlled-release effect for prolonging the internal activity time thereof, so that long-acting blood sugar reduction can be realized, and a weight-reducing effect of controlling body weight growth is further achieved. The invention further discloses a composition for reducing blood sugar and/or reducing body weight. Raw materials involved in the preparation method disclosed by the invention are all free from biotoxicity, high in safety, low in cost, simple in preparation process, and high in entrapment efficiency; the obtained compound is uniform and controllable in particle diameter, good in stability, long in internal activity time, good in body weight control effect, suitable for industrialized mass production, and good in application prospect.

The invention discloses an air bag arterial cannula with a suction function, and belongs to the technical field of medical devices. The air bag arterial cannula comprises a cannula body, a butterfly-shaped air bag, an air bag inflation tube, a drainage port, a cannula wall interlayer and a suction outlet; the cannula body is used for descending aorta perfusion, the butterfly-shaped air bag is usedfor blocking a gap between the cannula body and a descending aorta tube cavity, and meanwhile, possibly existing backflow blood is completely collected to a drainage port at the lowest point of a connection part of the butterfly-shaped air bag and the cannula; the air bag inflation tube is communicated with the butterfly-shaped air bag and is used for inflating gas or liquid into the butterfly-shaped air bag; the drainage port is used for sucking blood which flows backwards to the drainage port; the drainage port is arranged on an annular line at the joint of the outer surface of the cannulabody and the outer surface of the butterfly-shaped air bag; the interlayer of the cannula wall is a channel for leading out the reflux blood. The cannula is used for performing descending aorta distalperfusion after hypothermia with circulatory arrest of aortic arch operation, and the hypothermia with circulatory arrest time is obviously shortened.