The invention discloses a defibrillation device and method capable of conducting cardio-pulmonary resuscitation. The device comprises a pad plate, and a controller is arranged in the pad plate; an electrode slice is pasted to the chest of a patient, and the controller acquires the real-time heart rhythm of the patient through the electrode slice; the controller controls a pressing air bag to carryout cardio-pulmonary resuscitation pressing on the patient, detects the real-time heart rhythm of the patient, carries out matched filtering through an algorithm, filters out cardio-pulmonary resuscitation pressing interference signals, and judges whether the patient needs electric shock defibrillation or not; and if the patient needs electric shock, an electric shock instruction is given, and ifthe patient does not need electric shock, heart rhythm detection and judgment are conducted again until the heart rhythm of the patient returns to normal. According to the invention, an external automatic defibrillation device and a cardiopulmonary resuscitation instrument are combined. The pressing frequency of cardio-pulmonary resuscitation is controlled and output by the controller in a unified mode, so that the defibrillation device facilitates signal matching, can effectively filter waveform interference caused by pressing, not only can perform continuous cardio-pulmonary resuscitation,but also can perform effective electric shock defibrillation treatment, and improves the rescue success rate.