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A system for converting readily available standard off the shelf golf club parts into a interchangeable golf club system. A conversion system consists of a head insert which can be glued into the hosel of a standard golf club head. A shaft insert having a central flange is insertable and glueable into place on a standard shaft of a golf club. The shaft insert and the head insert forming a quick connect to attach the shaft to the golf club head. Through the use of different club heads representing the full range of woods, irons, and putter, each having a head insert pre-installed, the club may have emulating any club by attaching the desired club head. A shaft length adjustment is made by a cooperating pin installed in the top of the shaft and slidable within a number of slots provided in a telescoping sleeve slidable over the shaft.

The invention provides a cyclic single-chain trispecific antibody against human tumor. It comprises three parts. The first part is an anti-tumor Fab antibody, an anti-tumor single-domain antibody or an scFv. The second part is a reshaped Fab antibody against human CD3, a reshaped single-domain antibody against human CD3 or a reshaped scFv against human CD3. The third part is a reshaped Fab antibody against human CD28, a reshaped single-domain antibody against human CD28 or a reshaped scFv against human CD28. The present invention also offers the DNA sequence coding for this trispecific antibody, expression vectors containing this DNA sequence and host cells (E. coli) containing the vectors.

Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

The method and apparatus for information conveyance and distribution to bidirectionally focus or guide a wide spectrum of electromagnetic waves propagated over a possible variety of propagation media, including free space or wireless, surface wave, and cable or wired transmission lines. The apparatus communicates with information devices immediately adjacent to these media wherein the devices, which are not themselves part of the apparatus, may have electromagnetic access to one another. The apparatus maintains adequate signal to noise ratio and low distortion for a possible variety of different signal modulation and encoding types which it can support while permitting transparent, simultaneous communications among a variety of devices. Spread spectrum techniques may be used within the apparatus to mitigate propagation medium distortions and impairments as well as to control access and provide a means for securing information within the corridor and for obtaining revenue. Adapters may be employed to provide either full or half duplex access to the information devices which utilize it.

A portable, integrated physiological monitoring system is described for use in clinical outpatient environments. This systems consists of a plethora of sensors and auxiliary devices, an electronics unit (100) that interfaces to the sensors and devices, and a portable personal computer (102). Electrodes (106) are provided to acquisition electrocardiographic, electroencephalographic, and neuromuscular signals. Electrodes (108) are provided to stimulate neural and muscular tissue. A finger pulse oximeter (110), an M-mode ultrasonic transducer (112), an airflow sensor (114), a temperature probe (120), a patient event switch (116), and an electronic stethoscope (118) are provided. A portable personal computer (102) interfaces to the electronics unit (100) via a standard parallel printer port interface (258) to allow communication of commands and information to / from the electronics unit (100). Control and display of the information gathered from the electronics unit (100) is accomplished via an application program executing on the portable personal computer (102). Sharing of common data acquisition hardware along with preliminary processing of information gathered is accomplished within the electronics unit (100). The entire system is battery operated and portable. This system, because of its architecture, offers significant cost advantages as well as unique modes of operation that cannot be achieved from the individual physiological parameter measurement devices alone. The system allows for the integration of acquisitioned information from the sensors into a patient's database stored on the portable personal computer.

Low density composite particles made of a binder and filler material are provided for use in subterranean formations. The filler includes low density filler and optionally other filler. The binder includes a polymer and optionally cement. The particles may be employed as proppants useful to prop open subterranean formation fractures. The particles are also useful for gravel packing in subterranean formations, water filtration and artificial turf for sports fields. Methods of making the composite particles are also disclosed.

A robotic catheter system including one or more robotic catheter manipulator assemblies supported on a manipulator support structure. The robotic catheter manipulator assembly may include one or more removably mounted robotic catheter device cartridges and robotic sheath device cartridges, with each cartridge being generally linearly movable relative to the robotic catheter manipulator assembly. An input control system may be provided for controlling operation of the robotic catheter manipulator assembly. A visualization system may include one or more display monitors for displaying a position of a catheter and / or a sheath respectively attached to the robotic catheter and sheath device cartridges.

An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent / medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and / or preventing adjacent diseases or maintaining patency of the body lumen.

The present invention relates to wind generators installed off-shore, in particular at sea, to support structures forming a part of such wind generators, and to methods of making and installing such wind generators. The technical field of the invention is that of making, transporting, and installing wind generators for producing electricity, more particularly off-shore, and in large numbers, so as to form wind "farms". The wind generator of the invention comprises a wind turbine and a deployable telescopic pylon or support supporting the turbine, and a gravity base supporting the pylon or support.

A method is disclosed for effecting data interchange among software tools and repositories in a distributed heterogeneous environment in a computer system having at least one repository of a first type and at least one software modeling tool of a second type. The method includes the steps of registering and storing metadata describing a meta model in the repository. Next, a set of rules and streams of data are generated based on the rules, and then documents conforming to each of the metamodels are generated by reading the set of rules. An importer is written for use in importing into the repository the streams of data; and, an exporter is written for use in exporting from the repository the streams of data.

A method and system for managing the routing of traffic within a network develops a topological address space map of the network to enable a “best route” selection process. The network is comprised of a backbone connected to a plurality of peering partners. Points on the network monitor traffic flows. A central facility analyzes the traffic flows and routes within the network and performs intelligent routing management. Intelligent routing management ensures that traffic is properly routed through preferred routes on the network, and avoids inefficient routing. Intelligent routing management also selects new routes to be injected into the network in order to further improve the accuracy of the address space map of the network. Intelligent routing management ensures that bandwidth is requested and delivered topologically closely to peering partner networks, and that traffic is carried by the backbone for long haul data distribution in both directions.

A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical transmission member having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, an optical detector for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.