437 results about "Microbubbles" patented technology

The invention belongs to the technical field of film quality analysis and evaluation, and particularly relates to a flexible circuit board film pressing quality detection and analysis method and system. The method comprises the steps of generating a self-adaptive scanning path based on a design file and surface deformation data; performing multi-modal data acquisition and fusion along a path through optical surface scanning, ultrasonic tomography and an optical coherence tomography imaging assembly; potential defects are positioned, and size, shape, position and defect type probability values are quantized; judging the authenticity of the defect by adopting a three-stage mechanism of cross-modal probability comparison, physical characteristic logic verification and multi-frame time sequence verification; and performing weighted scoring on the real defect matching acceptance standard table, and performing disqualification marking or outputting a process optimization suggestion to the pressing equipment according to a scoring result. According to the invention, the imaging limitation of the transparent coating layer is broken through, the internal interface layering and the precise detection of the microbubbles are realized, and the closed-loop control from detection to production adjustment is formed.

The invention relates to the technical field of foamed silicone rubber surface detection, and discloses a foamed silicone rubber surface detection method based on image visual identification, which comprises the following steps: acquiring a color image of a foamed silicone rubber surface, carrying out graying and normalization processing, and generating a diffuse reflection effective detection area by using a polarization filter difference technology; color abnormity is detected based on an image gridding and gray statistical method, meanwhile, pore and microbubble defects are detected in combination with minimum value seed point extraction and an eight-neighborhood region growing algorithm, finally, various masks are fused, the defect area and number are counted, and a quality inspection report is generated; the method can effectively inhibit highlight interference and accurately identify uneven colors and pore microbubbles, the detection process does not need external training, calculation is efficient, and the method is suitable for rapid detection and quality control of surface defects of foamed silicone rubber.

The invention discloses an ultrasonic positioning microscopic imaging method and system based on joint resolution perception and vision Mangbar, and the method specifically comprises the steps: obtaining and preprocessing a plurality of modal angiography data, generating a microbubble motion sequence in combination with blood flow velocity field simulation data, and constructing a data set; inputting the data set into a mixed hierarchical feature pyramid fusion network, carrying out probability density estimation on a microbubble position based on a real-time multi-scale density field estimation algorithm, and introducing a resolution perception algorithm to enhance microbubble features to obtain a plurality of short-track images; performing dynamic feature decoupling and time-frequency analysis on the short-track image, extracting and encoding velocity component features and spatial-temporal context information of a vascular structure, and constructing a double-branch processing network based on visual Mangbar to obtain images respectively reflecting forward motion contribution and backward motion contribution, and finally generating a high-resolution blood vessel image through image fusion. The method has an important value for improving the efficiency and precision in microvascular imaging.

The invention relates to a metallized microbubble and a preparation method thereof, a construction method of a multifunctional composite probe, and a rapid bacterium capturing and sterilizing method, and belongs to the technical field of functional material preparation. The method aims at solving the technical problems that in the prior art, a metal coating on the surface of the hollow glass microbubble is not uniform, combination is not firm, and stability is poor. According to the technical scheme, the method is characterized by comprising the following steps: mixing surface-activated hollow glass microbubbles with a polyethyleneimine solution for reaction, and washing and drying to obtain polyethyleneimine-coated hollow glass microbubbles; then reacting with a single-stranded DNA buffer solution to obtain an intermediate product loaded with DNA; then introducing a silver nitrate solution to load silver ions on the surface of the compound; and finally, reducing through a sodium borohydride solution to prepare the metallized microbubbles. The metalized microbubbles prepared by the method can be used for constructing a multifunctional composite probe to realize efficient capture and synergistic antibiosis of targets such as bacteria.

Disclosed herein is a composition for enhanced ultrasound ablation and methods relating to same. The composition may include a microbubble-microdroplet cluster composition, wherein the microbubble-microdroplet cluster composition may include groups of negatively charged microbubbles and positively charged microdroplets permanently held together by their opposing electrostatic attractive forces to form a single, agglomerated entity.

The invention relates to equipment for synthesizing chlorinated polyvinyl chloride and a synthesis method thereof, and belongs to the technical field of chemical synthesis equipment. Through the synergistic effect of the cavitation effect of ultrasonic waves and the photocatalytic reaction, the ultrasonic waves generate a large number of tiny bubbles in the working solution, on one hand, the tiny bubbles just enable pvc particles with lower density to float and overflow, and photocatalyst particles with higher density are kept at the bottom, so that self-separation of reactants and a catalyst is achieved, and the self-separation effect of the reactants and the photocatalyst is improved. On the other hand, the microbubbles quickly collapse in an extremely short time after floating to the surface of the reaction liquid, a cavitation effect is generated, dispersion of the photocatalyst in the reaction stock solution can be promoted, and the contact opportunity of the photocatalyst and reactants in the reaction stock solution is increased. A local high-temperature and high-pressure environment generated when the microbubbles are broken can enhance the activity of the photocatalytic reaction, and the synergistic effect of the microbubbles and photocatalysis can accelerate the photocatalytic reaction rate, promote the chlorination reaction of chlorine and pvc particles, and improve the chlorination rate.

The invention relates to the technical field of quartz crucibles, and particularly discloses a melting method for reducing microbubbles on the inner surface layer of a quartz crucible. The arc vacuum melting in the melting method disclosed by the invention comprises the following steps of: rising a heat shielding plate to a position which is 350-450mm away from the upper edge of a mold, and melting the inner surface of a crucible for 45-75s by utilizing a high current which is more than 5000A; then moving down the heat shielding plate, keeping the current unchanged, and melting; the heat shielding plate is lifted, the current is adjusted to be 2200-2500 A, and a transparent layer is formed through vacuum melting; stable melting: adjusting the current to be more than 5000A, and performing high-temperature evaporation; then, the current is adjusted to be reduced to 1800-2200 A, and low-temperature melting is conducted for 120-240 s; and repeating stable melting to obtain the quartz crucible to be demoulded. By means of the technical scheme, the number of microbubbles of the prepared quartz crucible is obviously reduced, the compression strength of the crucible is greatly improved, and the service life of the crucible is greatly prolonged.

Provided herein are methods to treat various neurodegenerative disorders comprising delivering a viral particles to the whole brain, including both superficial and deep structures. In some aspects, the viral particles are administered at low dose levels to the CSF, in conjunction with microbubbles followed by application of focused ultrasound (FUS) to a region of interest of the brain, thereby causing entry of the viral particles to the brain.

The present invention provides a microbubble generating device and a microbubble generating method. The microbubble generating device includes a housing with openings at both ends, and at least one shearing assembly is disposed within the housing. The shearing assembly includes a first internal component, a second internal component, and a third internal component, wherein a shearing chamber is formed between the first internal component, the second internal component, and the third internal component. The microbubble generating device provided by the present invention can produce microbubbles with uniform micron and nanometer sizes according to practical production needs, and the microbubbles can exist stably in a liquid phase and are not prone to coalescence. The microbubble generating device also has the advantages of a simple structure, easy disassembly, good sealing, low leakage risk, low energy consumption, low equipment cost, and a small size.

A toilet includes a tank and a bowl. A bubble generation device including a nozzle is configured to release nanobubbles to the tank or the bowl. A controller is configured to generate a command for the bubble generation device to release nanobubbles from the nozzle into the tank and / or the bowl.

According to the chemical material detection method and system based on deep learning provided by the invention, the online adaptive training generative adversarial network BR-GAN is introduced, and the generator can dynamically learn background optical feature mapping under the fine tuning condition of production process parameters; meanwhile, a multi-layer convolution discriminator is used for recognizing time correlation of background optical features, so that a defect-free background reconstruction image matched with the current production condition can be generated, and a difference image is generated by calculating pixel-level residual errors and feature-level attention differences of a real-time image and the reconstruction background; microscopic bubble signals are effectively separated from complex backgrounds changing along with technological parameters, and the effect of accurately detecting microscopic bubbles is achieved.

A mixed abrasive synergistic enhancement immersion microjet processing system and method for RB-SiC ceramic microstructures is characterized by: the micro-abrasive air jet nozzle is driven by an active rack and driven gear, and one end is connected to a precision sandblasting machine containing micron-sized abrasive particles; its output end is immersed in a slurry tank containing submicron / nano-sized abrasive particles; the micro-abrasive air jet nozzle ejects a gas-solid two-phase flow and generates a large number of microbubbles; the driving effect of the microbubbles effectively mixes the submicron / nano-sized abrasive particles in the slurry tank with the gas-solid two-phase flow ejected by the micro-abrasive air jet nozzle, thereby obtaining a mixed abrasive synergistic enhancement immersion microjet; the waste liquid passes through a primary filter particle recovery outlet, a secondary filter particle recovery outlet, and a tertiary filter particle recovery outlet in real time, where the micron-sized abrasive particles and erosion debris are screened, dried, and classified for collection, ultimately achieving efficient and high-quality processing of RB-SiC ceramic microstructures.

The invention provides a method for detecting dissolved gas in transformer oil, and belongs to the technical field of dissolved gas in transformer oil, and the method comprises the following steps: firstly, transmitting a plurality of groups of ultrasonic waves with different frequencies into the transformer oil at the same time, obtaining and preprocessing a joint spectrum, and then utilizing a wavelet multi-scale decomposition technology considering a time sliding window to obtain a pre-processed joint spectrum; the signal is disassembled into a stable spectrum and three levels of fluctuation spectrums. Extracting the characteristics of interference, spectrum attenuation, waveform complexity, coupling, energy distribution and the like from each level of fluctuation spectrum, and calculating the influence characteristics of microbubbles on ultrasonic waves, including acoustic attenuation, propagation velocity, scattering, acoustic impedance change and nonlinear acoustic characteristics. By performing weight fusion on the three-level fluctuation spectrum energy ratio, comprehensive characteristics are generated and input into a gas calculation model, so that the state of gas in transformer oil is accurately evaluated and diagnosed, and the technical problem that an existing offline sampling analysis method is difficult to meet the requirement of a power system for evaluating the running state of a transformer in real time is solved.

The invention discloses a sealing ring processing quality monitoring system, and relates to the technical field of sealing ring processing monitoring. The system comprises a polarization-dark field composite imaging module which is used for obtaining a target image which eliminates specular reflection and highlights scattering characteristics of tiny bubbles through the synergistic effect of polarization filtering and annular dark field illumination; the microbubble feature enhancement module is used for carrying out feature extraction and enhancement on the target image by adopting a deep learning network comprising a multi-scale cavity convolution unit and a self-adaptive attention mechanism unit; and the self-adaptive threshold segmentation module is used for processing the enhanced image in combination with segmentation strategies of the dual-threshold screening unit and the attention map guide segmentation unit so as to accurately segment a micro bubble region. Through cooperation of polarization-dark field composite imaging, a microbubble feature enhancement network and adaptive threshold segmentation, high-precision rapid detection of the microbubbles on the surface of the transparent silica gel sealing ring is realized.

An ultrasound transducer ultrasonically processes a target volume by emitting a sequence of acoustic pulses to the target volume to alter tissue properties while at least one acoustic detector detects an ultrasound reflected signal from the target volume after each acoustic pulse, and a controller (i) estimates an activity of the contrast agent at the target volume based on a comparison between values of signal parameters in the reflected signal following successive acoustic pulses, and (ii) controls the ultrasound transducer to alter the tissue property based on the estimated activity.

According to the multifunctional heart color ultrasound acoustic contrast examination device, the stirring mechanism is arranged in the cylinder, and the sealing mechanism and the mixing mechanism are integrated on the stirring mechanism, so that the efficiency and the sealing reliability in the contrast agent stirring process are remarkably improved. Wherein the mixing mechanism is fixedly connected to the outer wall of the stirring shaft and can drive the stirring plate to efficiently stir in multiple directions when the stirring shaft rotates, so that a contrast agent and gas can be fully mixed to generate mixed liquid with uniform and stable microbubbles, and the imaging quality and diagnosis accuracy of heart color ultrasound acoustic contrast examination are improved.

The invention discloses a residual oil hydrogenation microbubble generating device, which is arranged at the front end of a residual oil hydrogenation fixed bed reactor, is used for pretreating a gas-liquid two-phase material, and comprises a first crushing assembly which is arranged in a tank body of a generating tank, is positioned at the lower part of the tank body and is provided with rotary crushing cutters which are arranged in a layered manner; the rotary crushing cutter is driven by a driving unit, rotates along a vertical rotating shaft and is used for crushing large bubbles into small bubbles; and the second crushing assembly is arranged in the tank body of the generation tank and located above the first crushing assembly, the second crushing assembly is provided with a horizontally-arranged filtering and crushing plate, and the filtering and crushing plate can be driven by the same motor in the driving unit to reciprocate in the vertical direction and is used for crushing the small bubbles into microbubbles. According to the invention, large bubbles in residual oil can be broken into small bubbles, so that the mass transfer and reaction efficiency of gas and liquid phases in a residual oil hydrogenation system is effectively improved.

The invention provides an automatic counting method and system for ultrasonic microbubbles in right heart acoustic radiography. The method comprises the following steps: acquiring a cardiac radiography image of a patient through high-resolution ultrasonic equipment; extracting a region of interest of the cardiac angiography image based on the cardiac vascular structure, and performing image registration operation on the cardiac angiography image by taking the region of interest as a reference point to obtain a registered image; carrying out pixel-by-pixel addition on two frames of pulse images with opposite phases in the registered image to obtain an enhanced image; determining the high-echo bright spots in the enhanced image as suspected microbubbles, and performing denoising processing according to the feature similarity to obtain real microbubbles; judging pathological conditions according to whether real microbubbles exist in the left atrium or not; if the real microbubbles exist in the left atrium, grading the abnormal blood flow according to the change data of the microbubbles in the left atrium and the right atrium. According to the method, through high-precision image registration, multi-modal feature analysis and dynamic parameter fusion technologies, the microbubble detection accuracy is improved, and quantitative grading of pathological conditions is achieved.

In the device, the Venturi tube comprises an inlet, a throat part and an outlet, a first through hole is vertically formed in the inlet, a second through hole is vertically formed in the throat part, and a third through hole is vertically formed in the outlet; the first plasma generating device is introduced into the liquid level cavity from the first through hole, first plasma is generated in gas-liquid two-phase discharging, active substances are directly generated in the liquid phase, the second plasma generating device generates second plasma active gas, and the second plasma active gas is introduced into the Venturi tube through the second through hole for aeration; the third plasma generating device generates third plasma active gas and guides the third plasma active gas into the Venturi tube through the third through hole for aeration, the container is communicated with the outlet so as to form microbubbles containing active components in the liquid, and the container comprises a fluid inlet and a fluid outlet which are formed in the wall of the container.

The invention discloses a water taking and ferromanganese removal device based on a seepage collecting gallery, and belongs to the technical field of ferromanganese removal of seepage collecting galleries, the water taking and ferromanganese removal device comprises a seepage collecting gallery main body, an aeration assembly and a vibration piece, a gabion is installed on the upper surface of the seepage collecting gallery main body, the aeration assembly is installed inside the gabion, and the vibration piece is installed on the upper surface of the seepage collecting gallery main body. According to the manganese ore catalytic oxidation device, external gas enters the aeration ball through the air inlet cover, the connecting pipe and the aeration pipe, and the gas is extruded through a microporous material of a bubble film to form microbubbles, so that the content of dissolved oxygen in a water body is greatly increased, a sufficient oxygen source is provided for a manganese ore catalytic oxidation reaction, and the gas-liquid mass transfer effect is enhanced; meanwhile, the other part of gas enters the spherical shell and blows the vibration ball to drive the vibration rod to swing, the impact ball impacts the vibration piece through the connecting block and the connecting rod and then is transmitted to the aeration ball to enable the aeration ball to swing greatly, a water body generates turbulent flow, and the contact area and frequency of pollutants and manganese ore are increased.

The invention provides a CD147-targeted nano ultrasonic contrast agent as well as a preparation method and application thereof. The contrast agent comprises gas vesicles derived from microorganisms and a CD147 nano antibody connected to the surfaces of the gas vesicles through a coupling agent. The hollow nanostructure of the gas vesicle endows the contrast agent with efficient acoustic reflection capability, and the ultrasonic signal intensity is greatly improved; the CD147 nano antibody has high affinity and high specificity, and can accurately recognize a CD147 antigen on the surface of a tumor cell. The biosynthetic gas vesicles are used for replacing traditional chemical synthetic gas microvesicles, a simple and efficient coupling process is combined, the preparation difficulty and equipment dependence are remarkably reduced, the contrast agent overcomes the defects of the prior art in the aspects of imaging performance, targeting performance, preparation process, safety and multifunctional diagnosis and treatment capacity, and the contrast agent has good application prospects. And a brand new technical path is provided for precise diagnosis and treatment of tumors.

The invention provides a single-array-element super-resolution ultrasonic imaging system based on deep learning, and the system is characterized in that the system comprises an ultrasonic collection module which comprises a single-array-element ultrasonic probe and is used for collecting a plurality of microbubble echo signals of an imaging target tissue at a single imaging angle; the system measurement matrix storage module is used for storing a corresponding system measurement matrix of the single array element ultrasonic probe at a single imaging angle; the microbubble reconstruction module is used for performing image reconstruction on each microbubble echo signal through a Moore-Penrose pseudo-inverse method according to the system measurement matrix to obtain a corresponding reconstructed microbubble image; the microbubble positioning module comprises a trained microbubble positioning network and is used for obtaining a corresponding microbubble positioning image according to the reconstructed microbubble image; and the image reconstruction module is used for carrying out superposition processing on all the microbubble positioning images to obtain a super-resolution ultrasonic microscopic image. In conclusion, the method can realize rapid imaging based on simple imaging equipment and has high imaging quality at the same time.

The present disclosure provides a systems and methods for measuring concentration, constituent size, or constituent shape of a composition in real time at the time of a parenteral administration based on the measurement of a physical property of the composition.

The invention discloses a rotational flow microbubble oscillation generator, system and method, relates to the technical field of microbubbles, and aims to strengthen gas-liquid mixing and mass transfer effects, so that the energy utilization efficiency is improved, and microbubbles with more uniform sizes are generated. The rotational flow microbubble oscillation generator comprises a rotational flow mixing component and a fluid oscillation component, and a feedback channel, and a flow inlet channel, an oscillation cavity, a vortex cavity and a bubble outlet which are communicated in sequence are arranged in the fluid oscillation component. Through the rotational flow mixing part, gas and liquid can be effectively mixed to form high-speed micro bubble jet flow, kinetic energy contained in the jet flow is utilized to cause sweeping motion in the fluid oscillation part, oscillation flow, feedback flow and vortex are formed, turbulent pulsation and collision are generated under the combined action of the oscillation flow, the feedback flow and the vortex, turbulent vortex shear breaking and jet flow shear breaking are caused, and the jet flow is formed. Therefore, the micro bubbles are subjected to secondary crushing, and micro bubbles with uniform size distribution and small average diameter are generated.

Methods, apparatus, and storage medium for obtaining a super-elevational resolution ultrasound localization microscopy (ULM) image. One method includes obtaining ultrasound signal acquired from a sample containing microbubbles by a transducer; reconstructing the ultrasound signal to form ultrasound images; filtering the ultrasound images to obtain microbubble signal with a filter; localizing and tracking the microbubbles based on the microbubble signal to obtain microbubble trajectories; performing dynamic localization by selecting in-plane microbubble signal and eliminating out-of-plane microbubble signal based on backscattered amplitudes of the microbubbles; and generating a super-elevational resolution ULM image based on microbubble positions corresponding to the in-plane microbubble signal.

Various aspects of the present disclosure are directed towards apparatuses, systems, and methods for electroporation ablation. The electroporation ablation catheter may include an electrode assembly comprising one or more electrodes configured to generate electric fields in target tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections, and an ultrasound transducer configured to generate a first set of ultrasound signals during a first electrical pulse sequence of the plurality of electrical pulse sequences and generate a second set of ultrasound signals after an end of the first electrical pulse sequence and before a beginning of a second electrical pulse sequence, the second electrical pulse sequence being an electrical pulse sequence subsequent to the first electrical pulse sequence.

The application discloses an ultrasonic-temperature double-triggered double-liquid gas phase change contrast agent and a preparation method thereof. The preparation steps comprise the following steps: adding an isotonic buffer solution into a prepared composite phospholipid film, oscillating after ultrasonic dispersion, obtaining a targeted phospholipid vesicle dispersion; then high-pressure double-liquid co-loading is carried out, and the phase change temperature and the ultrasonic response are calibrated; filtering through a filter membrane, collecting the precipitate after centrifugation, adding a protective solution after washing with a PBS buffer solution, and sealing and storing to obtain the double-liquid gas phase change contrast agent. After the contrast agent enters the body, under the ultrasonic double triggering of the physiological temperature and an ultrasonic imaging instrument, the double-liquid gas synchronously phase changes into a gaseous state, drives the contrast agent to rapidly expand from a nano-sized particle into a micron-sized microbubble, realizes ultrasonic enhanced imaging, and has a significant clinical application value.

The present invention discloses a method, apparatus, device, and storage medium for measuring the acoustic properties of contrast agent microbubbles. The method includes: a calibration phase, obtaining a pulse signal emitted by a transmitting probe and an echo signal received by a receiving probe, and calculating the receiving transfer function of the receiving probe using the pulse signal and the echo signal; a measurement phase, controlling the transmitting probe to sweep within a preset frequency range to emit an ultrasonic excitation signal, and controlling the receiving probe to receive scattered signals from microbubbles in a phantom blood vessel; extracting the subharmonic signal voltage amplitude from the scattered signal; using the receiving transfer function of the receiving probe to convert the subharmonic signal voltage amplitude into actual subharmonic scattering pressure at different frequencies; and determining the optimal subharmonic driving frequency and subharmonic scattering pressure based on the actual subharmonic scattering pressure. The present invention improves the measurement accuracy of the nonlinear scattering properties of microbubbles by obtaining the receiving transfer function of the receiving probe and using it to obtain the actual scattered acoustic pressure signal.

This invention provides a multi-stage, multi-angle, rapid diffusion oxygen dissolving three-dimensional non-clogging microbubble aerator. An air inlet pipe and an air pipe are sequentially connected along the air inlet direction. A rapid microbubble cutting and diffusion oxygen dissolving unit is fitted outside the air inlet pipe. An inner cylinder and an outer cylinder are sequentially fitted outside the air pipe from the inside to the outside. The inner cylinder has a first inner cylinder section, a second inner cylinder section, and a third inner cylinder section sequentially along the air inlet direction. A medium-sized bubble cutting and diffusion oxygen dissolving unit is installed on the outer wall of the first inner cylinder section, a large bubble cutting and diffusion oxygen dissolving unit is installed on the outer wall of the second inner cylinder section, and an air guiding unit is installed on the outer wall of the third inner cylinder section. An air diffuser unit is installed at the air outlet of the air pipe. This multi-stage, multi-angle, rapid diffusion oxygen dissolving three-dimensional non-clogging microbubble aerator effectively cuts air into microbubbles, effectively solving the problems of clogging and short lifespan of traditional aerators after long-term use, and is suitable for aerobic aeration treatment.

The invention relates to the field of electrolyzed water oxygen evolution reaction, and particularly discloses a preparation method of an oxygen evolution electrode for promoting bubble removal through cooperation of double Laplacian forces. A microscopic nanocone catalyst layer structure is grown on foamed nickel in an electro-deposition mode, a discontinuous three-phase interface is formed by means of the morphology to reduce bubble adhesive force, and under the simultaneous action of Laplace force generated by a microscopic V-shaped structure, microbubbles are promoted to be desorbed from the surface of a catalyst layer and leave a reaction area. A macroscopic gradient hole array is constructed on foamed nickel, and hydrophobic coatings are coated in holes, so that a hydrophobic and aerophilic effect is presented in the holes, gas in a reaction area is induced to gather towards a hydrophobic and aerophilic hole area under the action of surface tension, and the Laplace force generated by a gradient hole macroscopic V-shaped structure is utilized to promote rapid and directional transmission and removal of bubbles.