134 results about "Hyperthermia Treatment" patented technology

The invention relates to a prostate tumor thermal therapy device and method, the device comprises particles heating under the action of a magnetic field, and is characterized by further comprising an imaging positioning module, a particle implantation module, a particle fixing module, a magnetic field excitation module and a control and display module, the imaging positioning module comprises a multi-mode imaging device composed of an ultrasonic imaging unit, a CT scanning unit and an MRI imaging unit, and the multi-mode imaging device at least adopts two devices of the ultrasonic imaging unit, the CT scanning unit and the MRI imaging unit to construct a three-dimensional model of the prostate and the tumor. Through the arrangement, particles can be accurately positioned and fixed, the operation precision is improved, and the operation difficulty is reduced.

The high-frequency power calibration system comprises an illuminometer module, a voltage regulator module, a standard load module, a high-frequency source placement frame, a high-frequency current acquisition module, a control system and a computer, and all the modules are connected through signals to form the complete calibration system. The calibration method comprises the steps of load impedance standard power data acquisition, high-frequency power data acquisition, high-frequency power precision verification and high-frequency source module numbering and calibration data configuration. According to load impedance standard power data acquisition, different power frequency voltages are set, power frequency power and illuminometer data are acquired, and a relation function between the power frequency power and the illuminometer data is established; in high-frequency power data acquisition, different DA voltages are set, illuminometer data are acquired, and a relation function is established; the high-frequency power precision verification verifies the power precision by fitting the function relationship; and finally, the calibration data and the high-frequency source module number are correspondingly stored. The problem that the power calibration precision of the in-vitro high-frequency thermal therapy machine is insufficient is solved.

Disclosed is a leg thermotherapy rehabilitation device. Using a first convolutional neural network model with a temporal attention mechanism, the device mines hidden features of images from a patient's leg thermotherapy monitoring video over a predetermined time period to extract characteristic information about the temporal changes in the patient's leg skin color. A multi-scale neighborhood feature extraction module extracts multi-scale neighborhood correlation features of the device's heater power values ​​at different time spans within the predetermined time period. Based on the state change characteristics of the patient's leg thermotherapy, the device adaptively adjusts the heater power, dynamically controlling the thermotherapy temperature in real time based on actual conditions. This intelligently controls the thermotherapy temperature to prevent burns and secondary injuries to the patient.

This invention discloses a tumor interventional hyperthermia device, comprising a cylindrical body composed of an inner cylinder and an outer cylinder. A piston is located within the inner cylinder, and a push rod is connected to the rear end of the piston, extending out of the inner cylinder. The front end of the inner cylinder has a sleeve extending into the outer cylinder, with a needle fixed to the front end of the sleeve. An overflow tube communicating with the inner cavity of the inner cylinder is fixed to the top of the inner cylinder. The upper end of the overflow tube extends into the outer cylinder and is fitted with a dust cover. An isolation plug is fixed inside the overflow tube. The upper and lower ends of the overflow tube respectively have a first channel and a second channel, which communicate with the isolation plug. This invention has a simple structure, reducing manufacturing costs. When the injection speed is too fast, excess reagent can overflow through the isolation plug in the overflow tube, effectively preventing damage to the human body when reagent is injected too quickly.

The present application relates to the technical field of medical devices, in particular to a 3D printing vaginal hot perfusion aid, comprising an integrally formed medicine guide rod and wing, the medicine guide rod is columnar as a whole, an axial through hole is arranged in the medicine guide rod for penetrating a catheter, and the wing is arranged on the sidewall of the medicine guide rod. The design solves the problem that when a patient is treated with hot therapy, medicine needs to be injected into the patient's vagina, and the medicine injected into the vagina is prone to flowing out. The present application has a simple structure and is convenient for wide promotion and application.

The invention relates to the field of biomedical materials, in particular to a composite carrier for targeted drug delivery based on a diatom shell, and the carrier utilizes a natural diatom shell porous structure to anchor FeOmagnetic nanoparticles and graft a PNIPAM-co-AAc temperature-sensitive polymer film on the shell surface through oxygen plasma pretreatment and Schiff base reaction. The carrier realizes double-drug loading: a hydrophobic drug is loaded in a shell pore channel, and a hydrophilic drug is adsorbed on the surface of the membrane. And the anti-immune layer is grafted through a PEG silane coupling agent, so that the in-vivo circulation is prolonged to 45 hours. Heat is generated to 42-45 DEG C in an alternating magnetic field to trigger the temperature-sensitive film to shrink and release drugs, meanwhile, cancer cells are directly killed through thermal therapy, and the tumor inhibition rate reaches 78% and is remarkably improved compared with a traditional magnetic targeting carrier. Precise synergy of magnetic hyperthermia and drug release is achieved through structural innovation, and an efficient and low-toxicity solution is provided for cancer treatment.

The invention discloses a tomography and targeted energy thermal therapy system and method based on an acousto-optic coupling functional film layer, and relates to the technical field of noninvasive medical diagnosis and treatment. The system comprises an intelligent processing carrier, an acousto-optic coupling function film layer, a scanning mechanism, an energy treatment module and a processing and temperature control module. The intelligent processing carrier at least comprises a 20Hz-20kHz audio unit, a pickup unit, an optical signal unit and a processor; the acousto-optic coupling functional film layer is of a single physical structure and is inseparable, acoustic frequency conversion focusing imaging and targeted warm delivery at 42-47 DEG C are achieved in the same physical area in a time-sharing mode, the acoustic processing layer achieves 1000-8000 frequency doubling through a multi-stage resonance microcavity array, and the echo signal-to-noise ratio is larger than or equal to 15 dB; the scanning mechanism comprises a plurality of modes such as rotation, translation, multi-device array, human body movement, local limb movement, human body bearing support device movement and the like; the energy forms cover all types of light, electromagnetism, radio frequency and the like capable of generating a warm effect, including but not limited to non-contact or contact energy delivery modes. The traditional Chinese medicine composition is suitable for tumors, infections, inflammations, and all lesions sensitive to temperature of 42-47 DEG C including nervous system lesions such as amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, multiple sclerosis and the like, is low in cost, free of radiation and easy to popularize, and has extremely high creativity and practical value.

The application belongs to the technical field of biomedical application of nanomaterials, and discloses a magnetic graphene nanocapsule as well as a preparation method and application thereof. The application provides a magnetic graphene nanocapsule, wherein the magnetic graphene nanocapsule is of a core-shell structure, the core is a magnetic metal, and the shell layer is a magnetic graphene nanocapsule, compared with traditional magnetic metal oxides, the heat production capacity and acid resistance are significantly enhanced, and stable hyperthermia conditions can be provided in the stomach. The application further provides a preparation method of the magnetic graphene nanocapsule, wherein inexpensive and readily available raw materials such as metal chloride and nitrate are used, the synthesis conditions are simple, and the method is suitable for mass production. The obtained magnetic graphene nanocapsule can enter a specified site through oral administration, such a drug administration mode can avoid the problems of liver accumulation and side effects of nanoparticles after entering the blood, and potential toxicity of nanoparticles after entering the systemic circulation is avoided.

The invention relates to the technical field of medical instruments, and particularly discloses a multifunctional medical physiotherapy robot which comprises a cabinet, an operation screen and a six-axis robot, and a quick-change base is mounted on an output shaft of the six-axis robot. The core is that the quick-change base can be quickly detached and provided with four functional modules, namely a low-frequency pulse spray massage head, a radio frequency thermal therapy massage head, a shock wave massage head and a negative pressure massage head. Each massage head is connected with the execution end through a structure comprising a flexible connecting piece so as to adapt to the curved surface of the human body and compensate motion errors. Through the quick change mechanism and the central control system, integration and programmed collaborative application of multiple advanced physiotherapy technologies on one device are achieved, the problems that an existing device is single in function and poor in collaboration are solved, and the device has the advantages of being accurate in treatment, convenient and fast to operate and wide in adaptation disease range.

An antenna-based system for hyperthermia treatment of breast cancer, consisting of: a G-shaped microstrip patch antenna configured for operation at an ISM frequency of 434 MHz and having dimensions of 3.6 cm × 3.8 cm × 1.6 cm; an aluminum cavity chamber to accommodate the G-shaped microstrip patch antenna; a coaxial feed line configured to allow an impedance matching of 50 ohms to the G-shaped microstrip patch antenna; a bolus of deionized water configured to surround the aluminum cavity chamber, wherein the bolus of deionized water is further configured to serve as a cooling medium for controlling the skin surface temperature, and wherein the bolus of deionized water is further configured to reduce hotspots and improve the radiation efficiency of the G-shaped microstrip patch antenna; and A polyethylene film was positioned between the G-shaped microstrip patch antenna and the bolus of deionized water to prevent interference between the G-shaped microstrip patch antenna and a breast tissue phantom.

The present disclosure describes a flow reversing valve, along with associated methods and systems for providing forward flow, reverse flow, and bypass flow modes of operation, and integrating them into patient treatment systems, including those used for treating and inducing hyperthermia.

The present invention discloses a pH- and thermoresponsive iron nanogel and its preparation method and application. The iron nanogel is composed of Fe3O4 nanoparticles surface-modified with compound 2, compound 3, RNA or protein, polyethyleneimine-polyethylene glycol, and dopamine. Compound 2 is a small molecule compound containing ortho-dihydroxybenzene groups and having a protected boronic acid group structure at the end. Compound 3 is a small molecule structure in which phenyl diisothiocyanate-modified glycine has an exposed carboxyl group at the end that can react with amino groups. The iron nanogel in the present invention not only has good magnetic thermal properties but also has the ability to encapsulate drugs. Under the condition that certain acid and heat coexist, the iron nanogel can be controllably disassembled to release bioactive drugs, activate the body's immune system, and inhibit the growth of tumor cells by means of mild hyperthermia to achieve the effect of combined therapy.

includes an implantable intravesical floating hyperthermia device and an external pulse heating apparatus. The floating device includes a sealed non-metallic housing, a metal coil configured to inductively couple with an alternating magnetic field generated outside the human body to generate heat for tumor hyperthermia, a temperature sensor, a wireless transmission module, and a power supply module. The pulse heating apparatus includes at least one magnetic field generation module and a control module that controls the heating temperature according to the temperature signal from the floating device. The system supports multiple, timed, and temperature-controlled hyperthermia sessions with a single transurethral insertion, reducing patient trauma and enabling outpatient self-management.

The invention provides an image processing method and a laser interstitial thermotherapy system. The method comprises the following steps: determining an ablated region in a magnetic resonance image to be processed; segmenting a potential bleeding area in the ablated area; wherein the average amplitude of the potential bleeding area is higher than the average amplitude of a non-potential bleeding area in the ablated area; and comparing the temperature map corresponding to the magnetic resonance image to be processed with the magnetic resonance image after the temperature field is changed, and determining whether the potential bleeding area is a bleeding area. Based on a laser interstitial hyperthermia scene, in combination with spatial position characteristics, signal intensity characteristics and low sensitivity to ablation operation change of the bleeding area found by the applicant, the judgment precision of the bleeding area is comprehensively improved.

A single-cell transcriptome-guided multimodal synergistic injectable magnetically responsive biomimetic hydrogel system, its preparation method, and its application are described. This hydrogel platform is a three-level composite system of "matrix-microsphere-nanoparticle": the primary structure is a photocrosslinked methacryloyl hyaluronic acid three-dimensional network matrix; the secondary structure is GelMA microspheres loaded with MTPT nanoparticles prepared by microfluidic control; and the tertiary structure consists of bevacizumab and magnetite nanoparticles dispersed in the HAMA matrix. The MTPT nanoparticles have a mesoporous silica core, which is sequentially coated with temozolomide, a polydopamine coating, and a T7 targeting peptide. Under the activation of an alternating magnetic field, Fe3O4 generates a magnetothermal effect, which not only achieves local hyperthermia but also accelerates the time-sequential release of bevacizumab and MTPT, synergistically exerting the effects of chemotherapy, anti-angiogenic therapy, and hyperthermia.

This invention discloses a method for assessing hypoxia response based on dynamic evaluation of heart rate deceleration force and HRV, belonging to the field of biomedical signal processing. The method simultaneously acquires electrocardiogram (ECG) signals and environmental and blood oxygen parameters to dynamically correct the risk baseline; extracts frequency domain, time domain, and heart rate deceleration force features from the ECG signals and establishes a dual-channel cross-judgment logic; inputs the judgment results with the current blood oxygen saturation into a lightweight neural network inference output risk stratification; controls a wearable actuator to initiate multi-target stratified sequential stimulation including heat and vibration based on the stratification results, and adaptively updates the individualized hyperthermia prescription based on the intervention efficacy index, ultimately achieving dual-channel synergistic control of oxygen therapy and hyperthermia. This invention effectively solves the shortcomings of traditional methods, such as delayed early warning and inability to dynamically correct in non-networked environments, constructing a closed loop from precise monitoring to multi-target synergistic intervention, significantly improving the body's adaptability and resilience to hypoxia.

To provide an apparatus and a system for applying thermotherapy to at least a portion of a tissue site.SOLUTION: The apparatus and system comprise a heating probe 515 comprising a radiation region. The heating probe is connectable to an energy source for heating tissue with the radiating region. The apparatus and system comprises a sleeve 510. The heating probe is positionable within the sleeve, and the sleeve is configured to slide along the heating probe in a distal and / or proximal direction to position the radiation region within the portion of tissue to control the thermal therapy.SELECTED DRAWING: Figure 6

The invention relates to the technical field of radio frequency hyperthermia control, and particularly discloses a radio frequency hyperthermia intelligent control method based on micro-disturbance frequency sweeping and multi-mode perception, which comprises the following steps: applying a micro-disturbance radio frequency scanning signal to a treatment target area, and processing feedback data to dynamically reconstruct a real-time dielectric property map of a tissue; fusing the atlas with real-time temperature distribution data obtained by magnetic resonance, calculating instantaneous specific absorption rate distribution and predicting a thermal field evolution trend; constructing an optimization cost function based on the information, and generating a dynamic adjustment instruction for radio frequency power, frequency, phase and multi-antenna array focus position after solving; evaluating the control efficiency through a closed-loop verification mechanism and adaptively optimizing system parameters; by sensing the dynamic change of the dielectric property of the tissue in real time, feed-forward-feedback composite intelligent control over the radio frequency thermal therapy process is achieved, the problem of thermal field mismatch caused by the change of the tissue property in a traditional method is effectively solved, and the accuracy and safety of treatment are improved.

1. The name of the product under this design: Hyperthermia Device (Large Model). 2. Purpose of this design product: used as a foot thermal therapy device. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The top view and bottom view are omitted because they are not easy to see during use.

The invention relates to a multi-mode-based self-adaption rheumatism glove control method and a multi-mode-based self-adaption rheumatism glove control system. The method comprises the following steps: acquiring a multi-source data set including impedance data, thermodynamic distribution data, joint movement data, pressure distribution data and the like; respectively performing inflammation activity quantification, joint function evaluation and infection risk evaluation processing according to the data set to obtain an inflammation score, a function index and a risk identifier, and generating a state vector; based on the state vector and a historical state vector sequence loaded from a historical database, carrying out illness state stage identification processing to obtain an identification result, and generating a control instruction according to the identification result; and performing thermal therapy-electrical stimulation cooperative processing based on the control instruction, generating a pressure target value according to the state vector, performing pressure regulation and control processing, and generating a treatment log. According to the method, multi-source data are comprehensively analyzed, personalized control instructions and pressure regulation and control strategies are generated, accurate and personalized treatment schemes can be provided, and the treatment experience and rehabilitation effect of rheumatism patients are improved.

A new generation of precision medicine with interfaces processing the predictive feedback over the course of hyperthermia treatment sessions is provided. Implementation of MR-thermometry measurements and real-time spatial imaging can resolve many of the limiting factors currently associated with hyperthermia treatment. More significantly, implementation of artificial intelligence (machine learning) mediated image analysis and database construction can provide the international community with standards for monitoring, and thermal dose calibration.

The invention belongs to the technical field of biomedical sensors, and particularly relates to a harmonic detection device and a harmonic detection method in an alternating magnetic field, the harmonic detection device in the alternating magnetic field comprises a coil structure, two ends of the coil structure are provided with a plurality of coils with opposite spiral directions, and adjacent coils are tightly attached to each other. The coil structure is made of a hollow copper pipe, two ends of the hollow copper pipe are open, and cooling liquid is allowed to flow through the hollow copper pipe; the number of turns of the coils at the two ends of the coil structure is 3-7. The detection coil is wound through the copper pipe with the two open ends, cooling liquid is allowed to dissipate heat in the copper pipe in an internal cooling type circulation mode, and compared with an external cooling type heat dissipation mode in the prior art, the heat dissipation efficiency is greatly improved. The number of turns of the coils at the two ends of the hollow copper pipe is 3-7, and for the alternating magnetic field frequency of 100 kHz-1000 kHz commonly used for magnetic induction hyperthermia, the fundamental wave induced voltage level is reduced, so that the risk of device burnout caused by high frequency and high voltage is avoided.

A folded dipole patch antenna for use in a hyperthermia applicator is described. The antenna includes a dielectric circuit board, and a folded dipole microstrip antenna. The dielectric circuit board has a top side and a bottom side. The folded dipole microstrip antenna is formed on the top side and includes two meander paths mirror each other. A pair of parallel metallic strips is located on the bottom side. A coaxial feed port is connected to the pair of parallel metallic strips. The antenna is configured to resonate in a frequency range of about 434 MHz upon application of an input signal at the coaxial feed port. The folded dipole patch antenna has a small size and does not require an impedance matching circuit. The hyperthermia applicator is configured to emit microwave energy toward a target tissue within a human body.

The application discloses a kind of thermotherapy equipment, it is related to the technical field of thermotherapy machine, including suspension mechanism, machine head and suspension pedestal, the lower end of suspension mechanism is installed on suspension pedestal, machine head is installed on suspension mechanism, and suspension mechanism is equipped with suspension slide rail assembly, suspension slide rail assembly can drive machine head to lift, suspension pedestal is used to be connected with thermotherapy machine slide rail, and can reciprocatingly move along the length direction of thermotherapy machine slide rail, to drive machine head reciprocatingly move, proximity switch is equipped on the two sides of suspension pedestal, and proximity switch is used to induct with the two ends of thermotherapy machine slide rail, and controls the travel of suspension pedestal.The thermotherapy equipment can be automatically limited after being moved in position, improve use effect.

The invention relates a device for the hyperthermal treatment of a herpes disease on a skin, preferably a lip, wherein a control device is configured to regulate a treatment surface on an outer side facing the skin by heating at least one heating element in a heating phase to a contact temperature of 43-47° C. during a contact of the treatment surface with the skin, preferably the lip, and to maintain the contact temperature in a treatment phase for a time period between 1 and 10 seconds.

The present invention discloses a temperature-responsive two-photon MOF-based fluorescent probe, its preparation method, and application, relating to the field of fluorescent probe technology. MOF-199 is used as a nanocarrier, simultaneously loaded with a photothermal agent, gold nanorods (Au NRs), and a temperature-responsive pyridinium salt molecule (B). MOF-199 can degrade in the acidic tumor microenvironment, and the released copper ions react with overexpressed H2O2 through a Fenton-like reaction to generate ·OH, inducing tumor cell apoptosis and achieving chemodynamic therapy. Au NRs, with high photothermal conversion efficiency, can achieve photothermal therapy under near-infrared light irradiation, and local hyperthermia can further accelerate ·OH generation, thereby accelerating the chemodynamic therapy process. B, with its two-photon response characteristics, can achieve real-time temperature monitoring under near-infrared light irradiation, and the coated phase change material film can effectively prevent B leakage, achieving temperature-controlled release.

This application provides a laser hyperthermia device and a laser hyperthermia method. The laser hyperthermia device includes an ablation component and a laser probe. The ablation component emits laser light to ablate target tissue. The proximal end of the laser probe is connected to the optical path of the ablation component to conduct the laser light to the target tissue area. The laser probe includes a stator assembly and a rotor assembly arranged axially toward the distal end. The stator assembly is used to adjust at least one of the laser beam diameter, beam focal length, and light intensity. The rotor assembly is configured to rotate in a radial plane with the axial direction as the central axis to adjust the laser emission direction. The embodiments of this application enable more concentrated laser energy, thereby improving the accuracy of laser ablation, reducing energy requirements, and thus reducing ablation costs. During the rotation of the rotor assembly, the laser light is emitted toward the area of ​​the target tissue that needs ablation. Multiple ablations of the same target tissue can reduce the risk of infection of the ablation site and improve ablation efficiency.

The invention discloses an intelligent monitoring feedback type whole body thermal therapy exercise combination suit and an intervention method, the intelligent monitoring feedback type whole body thermal therapy exercise combination suit comprises a whole body wearable suit and a controller, thermal therapy modules are arranged on the head, the neck, the chest, the abdomen, the upper limbs and the lower limbs of the whole body wearable suit and are used for performing thermal therapy on each area, and the temperature of the thermal therapy module of each area is independently controlled; a heart rate sensor is arranged on the chest of a user, blood pressure sensors are arranged at the positions of upper limb cuffs, the thermal therapy module, the blood pressure sensors and the heart rate sensor are all connected with a controller, and the controller is in wireless connection with an upper computer. The cooperative mode of'multiple short-time lower-temperature thermal therapy + low-intensity movement matched with respiratory training 'is adopted, the targeted thermal therapy scheme is automatically generated through the APP and issued for execution, manual complex operation is not needed, the response speed is high, the defect that personalized feedback is lacked in the prior art is overcome, the intervention precision is improved, and the system is suitable for popularization and application. And the system can be used in various scenes such as daily home and office, and is wide in applicable crowd coverage.

The application provides a drug delivery system and a preparation method and application thereof, and relates to the technical field of biomedicine.The drug delivery system comprises mesenchymal stem cell exosomes, black phosphorus quantum dots and budesonide.The drug delivery system contains mesenchymal stem cell exosomes, has the functions of immune regulation, anti-inflammation and lung targeting, realizes lung targeted delivery of the black phosphorus quantum dots loaded with budesonide, and realizes precise regulation of lung temperature by utilizing the near-infrared photothermal effect of the black phosphorus quantum dots in asthma for the first time, so that local hyperthermia for allergic asthma is realized.The drug delivery system utilizes the photothermal effect of the black phosphorus quantum dots in the carrier to control the release speed of budesonide, is beneficial to maintaining the optimal drug concentration in the lung, and is expected to reduce the dosage and frequency of medication and reduce the risk of side effects.The application firstly cooperates the mesenchymal stem cell exosomes, local hyperthermia and the immune regulation effect of budesonide for the treatment of allergic asthma.