878results about How to "Short maintenance period" patented technology

Disclosed are devices and methods for detecting, preventing, and / or treating neurological disorders. These devices and methods utilize electrical stimulation, and comprise a unique concentric ring electrode component. The disclosed methods involve the positioning of multiple electrodes on the scalp of a mammal; monitoring the mammal's brain electrical patterns to identify the onset of a neurological event; identifying the location of the brain electrical patterns indicative of neurological event; and applying transcutaneous or transcranial electrical stimulation to the location of the neurological event to beneficially modify brain electrical patterns. The disclosed methods may be useful in the detection, prevention, and / or treatment of a variety of indications, such as epilepsy, Parkinson's Disease, Huntington's disease, Alzheimer's disease, depression, bipolar disorder, phobia, schizophrenia, multiple personality disorder, migraine or headache, concussion, attention deficit hyperactivity disorder, eating disorder, substance abuse, and anxiety. The disclosed methods may also be used in combination with other peripheral stimulation techniques.

A method for the detection of analytes using resonant mass sensors or sensor arrays comprises frequency encoding each sensor element, acquiring a time-domain resonance signal from the sensor or sensor array as it is exposed to analyte, detecting change in the frequency or resonant properties of each sensor element using a Fourier transform or other spectral analysis method, and classifying, identifying, and / or quantifying analyte using an appropriate data analysis procedure. Frequency encoded sensors or sensor arrays comprise sensor elements with frequency domain resonance signals that can be uniquely identified under a defined range of operating conditions. Frequency encoding can be realized either by fabricating individual sensor elements with unique resonant frequencies or by tuning or modifying identical resonant devices to unique frequencies by adding or removing mass from individual sensor elements. The array of sensor elements comprises multiple resonant structures that may have identical or unique sensing layers. The sensing layers influence the sensor elements' response to analyte. Time-domain signal is acquired, typically in a single data acquisition channel, and typically using either (1) a pulsed excitation followed by acquisition of the free oscillatory decay of the entire array or (2) a rapid scan acquisition of signal from the entire array in a direct or heterodyne configuration. Spectrum analysis of the time domain data is typically accomplished with Fourier transform analysis. The methods and sensor arrays of the invention enable rapid and sensitive analyte detection, classification and / or identification of complex mixtures and unknown compounds, and quantification of known analytes, using sensor element design and signal detection hardware that are robust, simple and low cost.

Disclosed herein is a system for rapidly resolving position with centimeter-level accuracy for a mobile or stationary receiver [4]. This is achieved by estimating a set of parameters that are related to the integer cycle ambiguities which arise in tracking the carrier phase of satellite downlinks [5,6]. In the preferred embodiment, the technique involves a navigation receiver [4] simultaneously tracking transmissions [6] from Low Earth Orbit Satellites (LEOS) [2] together with transmissions [5] from GPS navigation satellites [1]. The rapid change in the line-of-sight vectors from the receiver [4] to the LEO signal sources [2], due to the orbital motion of the LEOS, enables the resolution with integrity of the integer cycle ambiguities of the GPS signals [5] as well as parameters related to the integer cycle ambiguity on the LEOS signals [6]. These parameters, once identified, enable real-time centimeter-level positioning of the receiver [4]. In order to achieve high-precision position estimates without the use of specialized electronics such as atomic clocks, the technique accounts for instabilities in the crystal oscillators driving the satellite transmitters, as well as those in the reference [3] and user [4] receivers. In addition, the algorithm accommodates as well as to LEOS that receive signals from ground-based transmitters, then re-transmit frequency-converted signals to the ground.

Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 zeta-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.

Disclosed are devices and methods for detecting, preventing, and / or treating neurological disorders. These devices and methods utilize electrical stimulation, and comprise a unique concentric ring electrode component. The disclosed methods involve the positioning of multiple electrodes on the scalp of a mammal; monitoring the mammal's brain electrical patterns to identify the onset of a neurological event; identifying the location of the brain electrical patterns indicative of neurological event; and applying transcutaneous or transcranial electrical stimulation to the location of the neurological event to beneficially modify brain electrical patterns. The disclosed methods may be useful in the detection, prevention, and / or treatment of a variety of indications, such as epilepsy, Parkinson's Disease, Huntington's disease, Alzheimer's disease, depression, bipolar disorder, phobia, schizophrenia, multiple personality disorder, migraine or headache, concussion, attention deficit hyperactivity disorder, eating disorder, substance abuse, and anxiety. The disclosed methods may also be used in combination with other peripheral stimulation techniques.

Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.

The present invention discloses the present invention discloses a power toothbrush that includes a body portion 105. An elongated level arm 102 extends from one end of the body portion to a toothbrush head 101 disposed at a distal end of the toothbrush. The toothbrush head includes a plurality of brush bristles. The elongated lever arm 102 is mounted on a vibrating pivot 104 driven by rotational DC motor engaging and pushing a set of permanent magnets attached to a two-arm fork rotating along the lever arm 102. In a preferred embodiment, the DC motor drives a three-leg permanent magnets each disposed at a 120-degree phase from each other for driving the two-arm fork for generating a vibration that three-times the frequency of the DC motor's rotational frequency.

Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.

A charged particle optical system comprising a beamlet generator for generating a plurality of beamlets of charged particles and an electrostatic deflector for deflecting the beamlets. The electrostatic deflector comprises first and second electrodes adapted for connection to a voltage for generating an electric field between the electrodes for deflection of the beamlets, the electrodes being at least partially freestanding in an active area of the electrostatic deflector. The electrodes define at least one passing window for passage of at least a portion of the beamlets between the electrodes, the passing window having a length in a first direction and a width in a transverse direction. The system is adapted to arrange the beamlets in at least one row and to direct a single row of the beamlets through the passing window of the electrostatic deflector, the beamlets of the row extending in the first direction. A substantial part of the electrostatic deflector extends beyond the passing window in the first direction.

A hair-removing device (1) includes a laser source (3), an adjustable laser beam manipulator (5) for positioning a laser beam (7) of the laser source (3) in a target position (9) on a skin (11) to be treated, and an image sensor (47) for detecting an image (49) of the skin. The hair-removing device further comprises a control unit (17) which determines a position and orientation on the skin of a hair (13) to be removed, and which determines the target position of the laser beam as a function of said position and orientation of the hair. The control unit brings the laser beam manipulator in a state corresponding to the target position of the laser beam, and activates the laser source when the laser beam manipulator has reached said state. Thus, the hair-removing device is suitable for use by inexperienced users, and is particularly suitable for the consumer market. In a particular embodiment, the control unit determines the target position of the laser beam in a position (71) on the skin under which a root (15) of the hair is present, so that the root of the hair is destroyed and the hair-removing device (1) is an epilating device by means of which the hair is removed for a relatively long time or even permanently. In another embodiment, the control unit determines the target position of the laser beam in a position (65) on the hair where the hair comes out of the skin, so that the hair is burnt through near the skin surface and the hair-removing device (1″) is a shaving device by means of which a high skin smoothness is obtained.

An audio encoder adapted for encoding frames of a sampled audio signal to obtain encoded frames, wherein a frame has a number of time domain audio samples, having a predictive coding analysis stage for determining information on coefficients of a synthesis filter and information on a prediction domain frame based on a frame of audio samples. The audio encoder further has a frequency domain transformer for transforming a frame of audio samples to the frequency domain to obtain a frame spectrum and an encoding domain decider for deciding whether encoded data for a frame is based on the information on the coefficients and on the information on the prediction domain frame, or based on the frame spectrum. Moreover, the audio encoder has a controller for determining an information on a switching coefficient when the encoding domain decider decides that encoded data of a current frame is based on the information on the coefficients and the information on the prediction domain frame when encoded data of a previous frame was encoded based on a previous frame spectrum and a redundancy reducing encoder for encoding the information on the prediction domain frame, the information on the coefficients, the information on the switching coefficient and / or the frame spectrum.

A battery-cell converter (BCC) management system is disclosed. The BCC system comprises one or more battery-cell converter units that are configured to provide regulated main power output from the outputs of DC / DC converters inside the battery-cell converter units. Each battery-cell converter unit comprises an electrical energy storage cell bank, one or more DC / DC converters, one or more electrical connection devices and a monitor and control module coupled to other components of the battery-cell converter unit. Multiple battery-cell converter units can be stacked in series to increase output voltage. In another embodiment, multiple battery-cell converter units can be connected in parallel to increase output current. Accordingly, the BCC management system disclosed improves battery pack usage efficiencies, increase battery pack useable time per charge, extend battery pack life-time as well as lower battery pack manufacturing cost.

A microchip for control of a switch mode power supply (SMPS), with said microchip also having the ability to measure capacitance of an electrode or sense plate structure or structures, and use of a low power, power supply structure to supply said microchip, said power supply structure distinct from the main energy path via said SMPS to a load. The microchip may control said SMPS to transition between an active state and an inactive state, with the measured capacitance used to determine a condition for state transition. In said SMPS inactive state, only the microchip draws power to operate its capacitive sensing circuitry, leading to a significant SMPS standby losses decrease compared to prior art. Further teachings by the present invention include capacitive sensing based data transfer, universal charging platforms for mobile devices, noise immunity enhancements, various lighting embodiments as well as SMPS operation improvements.

An apparatus for conducting aqueous liquid media includes a plurality of static mixers, a gas distributor assembly with a plurality of nozzles, at least one impeller having blades attached thereto and a plurality of static mixer assemblies having flow guide elbows and collectors. The static mixer assemblies are independently and separately mounted to orient to the current leaving the blade tips of the impeller. Swirlers are also described as being utilized in place of the static mixers.

The present invention relates to seven isolated breast cancer-associated (BCA) polynucleotides, polypeptides, and variants thereof. The invention also relates to BCA antagonists. The invention also encompasses pharmaceutical compositions comprising BCA polynucleotides, BCA polypeptides, or BCA antagonists. The invention also contemplates methods for preventing or treating cancer, particularly breast cancer, comprising administering to a patient in need of such treatment a composition comprising a BCA polynucleotide, polypeptide, antagonist, or variant thereof. The invention also relates to methods for diagnosing, staging or determining a prognosis of a BCA-related disorder.

Rapid mass spectrometric immunoassay methods for detecting and / or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte / internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody / antigen of known concentration.

Heating / defrost constructions of a very low temperature refrigeration system having a defrost supply circuit and a defrost return bypass circuit optimizing the heating / defrost cycle, preventing overload (excessive pressure) of its refrigeration process and protecting components from damaging temperatures. The defrost cycle operates continuously, when required, and provides a shorter recovery period between heating / defrost and cooling operating modes. The rate of the temperature change during cool down or warm up is controlled in an open loop fashion by controlled refrigerant flow in bypass circuits.

A data processing apparatus has a data saving control portion. At shutdown, within the period after a fall in the source voltage is detected until the source voltage falls down to the lower limit at which the apparatus is guaranteed to operate, the data saving control portion saves to a non-volatile memory all the data needed to restore the state of an electronic circuit portion.

Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol / L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. Use of these substances does not adversely affect lipid profiles. By initiating rapid ketosis and accelerating the rate of ketoadaptation, this invention is useful for the avoidance of glucose withdrawal symptoms commonly experienced by individuals initiating a ketogenic diet, and minimizes the loss of lean body mass during dietary restriction.

This invention pertains to a product and a method for making the product. The product is a lightweight solid porous metallic product containing small solid spheres having a coating of a primary alpha phase thereon disposed in a solid metal alloy eutectic matrix. The method includes the steps of mixing the hollow rigid spheres and a metal alloy, which metal alloy can be preheated to render it molten, in order to form a dispersion of the spheres distributed in the molten alloy; initially cooling the dispersion to render it semi-solid whereby the spheres are coated by a solid and the coated spheres are disposed in the semi-solid mixture of the solid and liquid; and finally cooling the sphere-containing semi-solid mixture to a temperature at which the sphere-containing semi-solid mixture becomes solid and the product is formed.

A supercharged internal combustion engine system wherein the supercharger assembly includes an ejector pump driven by high-pressure air for pumping intake air into engine combustion chamber. The ejector pump uses a supersonic driving nozzle and a diffuser, each of which can be provided either with a fixed throat area or with a variable throat area. The system includes means for sensing engine power demand and controlling the supercharging action. Effective supercharging with fast response to demand is achieved even at low engine speeds. During periods of natural engine aspiration the ejector pump can be by-passed to reduce flow impedance. The invention permits increasing power output from small displacement engines. As a result, acceleration and grade ascent capabilities of automotive vehicles with small displacement engines having good fuel economy is improved. The system can be also operated to reduce engine exhaust emissions during cold start.

A method and apparatus is provide for playing keno-type games wherein a player can redeem a winning ticket remotely (e.g., over the Internet, by email or phone, etc.) instead of having to return to a point of purchase of the ticket to redeem the ticket. The keno-type game can be played using paper tickets or on a computer system, for example, coupled to the Internet.

A tailgate table having a first arm, a second arm, and a table member is disclosed herein. The first arm is configured for easy attachment to the existing trailer hitch receiver of a vehicle. The table member attaches to the second arm, which attaches to the first arm. The table member is configured with sidewalls and a bottom forming an interior. The interior may be compartmentalized. A top is hingedly attached to the table member to provide a substantially planar upper working surface when the top covers the interior.

A system and method for quantifying the working capital benefit of pooling a number of separate cash accounts. The average (mean) cash balance of the pooled account is determined to be the sum of the means of each of the individual accounts. Similarly, the standard deviation of the pooled account is determined to be the square root of the sum of the squares of the standard deviations of the individual accounts. Accordingly, the minimum cash level of the pooled account is 2.3 times the square root of the sum of the squares of the standard deviations of the individual accounts. In order to determine the benefit of pooling, the present invention determines the difference between the minimum aggregate cash required by the separate companies and the minimum cash required in the pooled account. If pooling is to be beneficial, from a working capital perspective, the minimum cash required in the pooled account will be significantly less than the aggregate cash required by the separate companies.

A target is illuminated with illumination light for image capture by a solid-state imager of an imaging reader. Internal reflections of the illumination light at a window are minimized, if not eliminated, by configuring the window as a non-planar optical element operative for redirecting the internal reflections away from the imager to enhance reader performance.

The invention concerns a non rotation-symmetric but root-analogue or tooth socket-analogue dental implant of the same size and shape as the root of the extracted tooth with macro retentions protruding from the implant surface (107, 113, 116).Macro retentions (107, 113, 116) are strictly limited to surface areas of the implant in the interdental space next to spongy and thick bone and in case of the last molar, facing the bone at the end of the tooth row. The diameter of the dental implant in transverse direction next to the thin cortical bone buccal and lingual / palatinal is identical to the alveolar bone or preferably stands back to avoid any pressure induced resorption and fracture of the thin cortical bone layer, respectively, at any cost.

A medical dialysis system including a filtration system configured to filter a water stream, a water purification system configured to purify the water stream in a non-batch process, a mixing system, and a dialyzer system. The mixing system includes a supply of dialysate components, a conductivity sensor positioned within a fluid pathway through which the water stream flows, and a control mechanism having a pump configured to control an amount of the one or more dialysate components added to the water stream from the supply. The mixing system can produce a stream of dialysate from mixing the one or more dialysate components with the water stream in a non-batch process. The dialyzer system includes a dialyzer, a plurality of pumps capable of pumping the stream of dialysate across the dialyzer, and another conductivity sensor positioned downstream of the dialyzer within a fluid pathway through which the water stream flows.

An improved method to manage the flow of heat in an active regenerator in a magnetocaloric or an electrocaloric heat-pump refrigeration system, in which heat exchange fluid moves synchronously with the motion of a magnetic or electric field. Only a portion of the length of the active regenerator bed is introduced to or removed from the field at one time, and the heat exchange fluid flows from the cold side toward the hot side while the magnetic or electric field moves along the active regenerator bed.