221results about How to "low toxicity" patented technology

The invention discloses micro-capsule granules and a preparation method thereof. The pesticide micro-capsule granules mainly comprise the following ingredients in percentage by weight: 5 to 75 percent of pesticide active ingredient, 1 to 10 percent of capsule wall material, 1 to 3 percent of wetting agent, 3 to 8 percent of dispersing agent, 0 to 10 percent of adjuvant and 10 percent of carrier filler. The preparation method comprises the following steps of: wrapping a micro-capsule by using active pesticide as a capsule core and using a high molecular material as a capsule shell material; preparing a micro-capsule suspending agent CS from water serving as a basic dispersant medium; and drying the micro-capsule suspending agent CS to prepare granules by using drying equipment to form a pesticide new formulation of the micro-capsule granules with control release effect. The invention has the advantages that: the pesticide micro-capsules are more environmentally-friendly and safer for a human body, have good control and prevention effects on targeted pests and are convenient to use.

Microorganisms which ferment common sugars into 1,2-propanediol, synthetic operons to effect the transformation, and methods to produce 1,2-propanediol by fermentation of common sugars using the transformed microorganisms are disclosed.

The anti-fake pesticide-germicide is prepared with boron, saponin, pyrethroid, organophosphorus pesticide and alcohol. After the pesticide-germicide is set into various kinds of dry small mouth bottle with the lid opened for 0.25-2 hr, white snowflake-like crystal will grow around the bottle mouth, and this makes it possible for the user to identify the truth of the pesticide-germicide. Compared with pesticide-germicide of alone pyrethroid and organophosphorus pesticide, the pesticide-germicide of the present invention has greatly raised effect, lowered toxicity, lowered cost and reduced consumption.

This invention provides a pharmaceutical composition comprising a non-peptide osteogenesis-promoting substance and a polyethylene glycol or a derivative thereof, which can be advantageously used as a agent for preventing or treating various bone diseases (e.g., osteoporosis) in view of the high oral absorbability and stability of the active ingredient.

The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN's in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable. In one embodiment, this includes use as a research tool, including studies of specific genes and studies to identify specific genes regulated by the transcription factors targeted. In another embodiment, the present invention provides for using polyamides for NF-kB-specific CODN delivery in the treatment of myocardial ischemia/reperfusion and myocardial infarction, heart failure and hypertrophy, cardioprotection, stroke, neuroprotection, sepsis, arthritis, asthma, heritable inflammatory disorders, cancer, heritable immune dysfunctions, inflammatory processes, whether caused by disease or injury or infection, oxidative stress to any organ whether caused by disease, surgery or injury. The decoys may be any transcription factors, including, but not limited to, NF-kB, AP-I, ATF2, ATF3, SP 1 and others.

The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.

The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.

The invention provides an application method of an ester-based hydroximic acid collecting agent to mineral flotation, and belongs to the technical field of mineral flotation. The structure of the ester-based hydroximic acid collecting agent is shown in the formula I shown in the specification, wherein in the formula I, R is a C1-C17 alkane base or C2-C17 alkylene. Due to the fact that the molecule of the ester-based hydroximic acid collecting agent contains an ester base and a hydroximic acid base, more ligating atoms and more coordinating groups are obtained, through chelation and metal ions, the more stable complex compound can be formed or strong adsorption is formed on the surfaces of metal oxide minerals, and floatation recycling of rare earth ores, titanic iron ores, scheelite, wolframite, scheelite and wolframite mixture ores or tin ores ca be strengthened; compared with an existing hydroximic acid collecting agent, due to the fact that the ester base exists in the molecule, the beneficial effects of being good in biodegradability, small in poisonousness and friendly to the environment are achieved.

The invention discloses a method to extract corn yellow pigment with microwave-ultrasonic extraction; the method combines the microwave technology with the ultrasonic technology, and uses over 90% ethanol and petroleum ether mixed solution at 60-90 DEG C as the extractant to extract the yellow pigment from the corn gluten meal of the by-product of corn starch production through wet process; the particle size of raw materials is 0.19-0.36mm; the ratio of the mixed solution of the extractant between ethanol and petroleum is 1:1 (volume ratio) ether, and the liquid material ratio is (6-15):1 (volume-to-weight ratio); the microwave power is 600w to 1,000w, and the processing time is 5s to 100s, and the temperature is 47 to 57 DEG C; the ultrasonic power is 300w to 600w and the processing time is 10min to 40min, and the temperature is 47 to 57 DEG C; the filtrate is decompressed and evaporated at 30 to 40 DEG C to get orange-red paste which is processed with n-hexane elution and filtered to remove insoluble protein, an then dried to constant weight in vacuum at 35 to 45 DEG C to weigh and calculate the extraction rate. The method has low toxicity of extractant and high yield of extracts, which solves the problem of long extraction time by the original method and is easy to be industrialized.

The invention relates to a composition comprising 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol, and application thereof in preparing a medicine for treating cerebrovascular diseases, particularly ischemic cerebrovascular diseases. The typical ischemic cerebrovascular disease is cerebral infarction.

The present invention provides a thienopyrimidine compound, represented by the formula

• • [wherein, R¹ is C_1-4 alkyl, R² is (1) phenyl optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C_1-4 alkylamino and di C_1-4 alkylamino and the like, R³ is a hydrogen atom or C_1-4 alkyl, R⁴ is C_1-4 alkyl optionally having a substituent such as C_1-4 alkoxy-carbonyl, carboxyl, mono C_1-4 alkylamino and N—C_1-4 alkyl-N—C_7-10 aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.

The invention relates to synthetic ceftizoxime acid and a method for preparing ceftizoxime sodium from the synthetic ceftizoxime acid. The preparation process comprises the following steps: slowly adding a crystallization solvent in a crystallization liquid until the crystallization liquid becomes slightly turbid, stopping adding the solvent, slowly stirring and growing crystals for 0.5 hour, continuously adding the residual solvent, and stirring and growing the crystals for 1 hour after the residual solvent is completely added. The product prepared by the optimized process in the invention has remarkably improved quality although the yield is lowered by 1.0-1.5%; and the product crystallization state is obviously improved and the product quality problem of clarity stability in the period of validity is solved.

The invention relates to a preparation method of a plant growth regulator, in particular to a preparation method of 24-epibrassinolide, which belongs to the chemical field, and comprises the following steps that: 1. starting from ergosterol 1, an intermediate body 3 is prepared through two reactions, i.e. methyl sulfonyl and hydrolysis according to a traditional synthesis process; 2. the intermediate body 3 is oxidized by a novel oxidation system osmium tetroxide/inter-chloro benzoic acid peroxide to prepare an intermediate body 4; and 3. the intermediate body 4 is finally converted into the 24-epibrassinolide 8 through four reactions, i.e. reduction, rearrangement, dihydroxylation and lactonization according to the traditional synthesis process. Compared with the traditional oxidation system chromium trioxide/pyridine used in the oxidization of the intermediate body 3 into the intermediate body 4, the novel oxidation system used by the invention has the advantages of convenient operation and little pollution, and is more applicable to industrial production.

The invention relates to a novel bio oil-starch adhesive for the artificial board and a preparation method thereof, which belong to the technical field of the artificial board in the wood processing. The adhesive uses starch and bio oil as the main raw material. The preparation method comprises the following steps: firstly carrying out acidolysis and oxidation treatment on the starch and simultaneously carrying out purification treatment on the bio oil; then carrying out proportioning on the processed bio oil and starch according to proper proportion and preparing linear high molecular polymer by addition and polycondensation reactions; adding polyvinyl alcohol into the high molecular polymer to prepare a main agent of the adhesive by esterification; and finally adding a borax cross-linking agent and diisocyanate into the main agent of the adhesive to prepare the bio oil-starch adhesive. The invention has the characteristics of novel design, standard process, no environment pollution and the like. The prepared adhesive has the advantages of environment protection, low cost, good water resisting property, high stability and the like and can be widely used in the fields of building materials, house decoration, home decoration and the like.

This invention relates to a novel synthesis for the preparation of benzoxazine components from phenolic components, aldehyde components, and amine components in a solvent other than toluene.

The invention relates to an ultraviolet-curable high-transparency high abrasion-resistant and high scratch-resistant coating material and a preparation method thereof, in particular to an organic/inorganic hybrid coating material composited in nano scale by using a sol-gel method, and a preparation method of the organic/inorganic hybrid coating material. The coating material contains silicic ester, hydrolysable silane containing epoxide groups, and photo-initiator; taking mineral acid as catalyst, the silicic ester is hydrolyzed in alcoholic solvent, so as to obtain silica sol; the hydrolysable silane containing the epoxide groups and the silica sol are hydrolyzed and condensed, so as to obtain a stable, transparent and homogeneous coating composition; and the coating composition is dip-coated, spray-coated or spin-coated on the surface of an apparatus, and is ultraviolet-cured, so as to obtain a high abrasion-resistant and high-transparency coating. The coating material can be used as a protective layer for an automobile lamp shade, an instrument panel, an optical disk, a resin lens or the like.

The invention relates to an electrochemical luminescence adapter sensor as well as a preparation method and the usage thereof, and in particular relates to an electrochemical luminescence adapter sensor established by taking Eu (III)-MWCNTs as luminescent material, a preparation method of the electrochemical luminescence adapter sensor, and the usage of the electrochemical luminescence adapter sensor prepared by the method in measurement of thrombin. The electrochemical luminescence adapter sensor has the advantages of excellent accuracy, stability and reproducibility and high sensitivity and has an important significance in the popularization of practical application of the adapter sensor in disease prevention, disease diagnosis and drug screening.

The invention provides a traditional Chinese medicament containing far-infrared-anion nano silver, zinc and selenium elements for externally treating burns and scalds, belonging to the production technical field of preparation of the medicament for externally treating burns and scalds by a high-tech nanometer technology. Burns and scalds are injuries on a body surface tissue caused by a heat source, and large-area deep burns and scalds can be complicated by shock, septicemia and the like; and the content of zinc, copper, ferrum and selenium is low and the content of nickel and aluminum is high in human body, so burn shock and lead poisoning easily occur. In the traditional Chinese medicament, rhizoma coptidis, phellodendron bark and radix scutellariae can clear away heat and toxic materials and realize antibiosis and anti-inflammation; rhubarb can improve local disturbance of blood circulation; and tree peony bark, red peony root and dried rehmannia root can clear away heat, cool blood and activate blood circulation and reduce exudates on a wound surface. In general, the traditional Chinese medicament can be mainly used for clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis, resisting exudation, promoting growth of epithelial cells, accelerating wound healing and realizing no black spots after healing; and a broad-spectrum high-effective nano silver system '(AT) antimicrobial' is added to the traditional Chinese medicament, thus the nanometer technology greatly improves the curative effect of the medicament and provides the latest scientific research direction for quick recovery of burns and scalds.

The invention discloses a preparation method of a magnetic fluorescent dual-function nano particle with nuclear shell structure, comprising the following steps: (1) magnetic nano particles are prepped by a conventional method, and then the magnetic nano compound particles with amination surfaces are obtained by adopting the conventional method; bromo-alkyl acylbromide is adopted to react with the amino on the surface of the amino, so as to obtain the initiator-modified magnetic nano particles; (2) the initiator obtained in the step (1), fluorescent monomers, catalyst, ligand and reducing agents form a polymerization system, and the polymerization system is dissolved in solvent, the shell formed by fluorescence polymers is obtained by carrying out electronic activation regeneration atom transfer radical polymerization, so as to obtain the magnetic fluorescent dual-function nano particle with nuclear shell structure; as the invention adopts the fluorescent monomers to carry out active radical polymerization directly, and the obtained grafting fluorescent polymer shell is linked on the surface of the magnetic nano particles in a covalent way, so as to be beneficial to maintaining stable performance of the magnetic fluorescent dual-function nano particle with nuclear shell structure in the practical using process.

The invention discloses a compound. The compound is prepared from berberrubine and magnolol through two times of nucleophilic substitution reactions under certain conditions. According to the compound, the inventor is guided by the traditional Chinese medicine pair theory and the traditional Chinese medicine clinical medication experience, berberrubine and magnolol are purposefully and selectively combined through a specific synthetic method, and the obtained compound has the effects of increasing the effect and reducing toxins, and has better effects on the aspects of inflammatory resisting, tumor resisting, cancer resisting, hyperglycemia and hyperlipidemia reducing, bacterium resisting, cardiovascular and cerebrovascular disease resisting and the like. Meanwhile, the invention discloses a preparation method of the compound and application of the compound in preparing medicine for treating tumors, cancer, hyperglycemia, hyperlipidemia and the cardiovascular and cerebrovascular diseases.

This invention describes photopolymer printing plate developing solvents comprising diisopropylbenzene, alone or in combination with one or more co-solvents. Compared with solvents of the prior art, the developing solvents of the present invention have lower toxicity, higher flash points, a milder and more pleasant odor, increased resistance to thermal decomposition, higher solvency, faster dry time, and pose reduced threat to the environment. The solvents of the present invention can exhibit azeotropic-like properties resulting in improved recycling characteristics and reduced drying times. Also, the solvents of the present invention exhibit a degree of selective solvency towards non-crosslinked photopolymers vs. crosslinked photopolymers that is not seen in solvents of the prior art.

The invention discloses a Toltrazuril suspending agent dispersible in water and a method for preparing the same. The Toltrazuril suspending agent comprises 1 to 15 percent of Toltrazuril, 0.01 to 2.0 percent of a surfactant, 0.01 to 2.0 percent of an emulsifier, 0.1 to 0.3 percent of a preservative, 0.2 to 2.0 percent of a flocculant, 0.1 to 2.0 percent of a suspending aid, 1 to 20 percent of a wetting agent and 40 to 88 percent of purified water.

The invention discloses an expeditious method and formula for treating cancer patients that reaulst in tumor suppression and remission, the suppression of mobilization and adhesion of cancer cells, and repression of pathogens, such as infectious bacteria and viruses. Administration is by oral ingestion or direct injection into tumors or intravenous drip etc. The invention employs control of intracellular and extracelular ionic physiology by administering alkaline salts, thereby restoring localized and/or systemic cellular ionic physiology, depriving cancerous cells of their ability to grow rapidly, and simultaneously normalizing their local environment, thereby inhibiting angiogenesis, enabling immune responses, and simultaneously reducing pain. The method further promotes correction of acidotic conditions often associated with cancer and other diseases, thereby potentiating biological functions of immunity and repair.

Low molecular weight compound exhibiting an osteogenesis-promoting action having the general formula (I) or a pharmacologically acceptable salt thereof:

The invention discloses a mixed nickel (II) complex based on phosphite and unsaturated n-heterocyclic carbene as well as a preparation method and application thereof. The chemical compound of the mixed nickel (II) complex is Ni[P(OR1)3][(R2NCHCHNR2)C]X2. In the mixed nickel (II) complex based on phosphite and unsaturated n-heterocyclic carbene disclosed by the invention, a hydrogenation addition reaction of styrene or substituted styrene against electron-deficient heterocyclic aromatic can be efficiently catalyzed in the presence of magnesium to synthesize a 1,1-diphenylethylane compound, which is the first case of the mixed nickel (II) complex catalyzing the hydrogenation addition reaction by adopting phosphite and unsaturated n-heterocyclic carbene as assistant ligands.

The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.

The invention relates to a preparation method of a drug for nourishing blood, relaxing muscles and treating rheumatism. Aiming at the defects of the prior art, the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism is provided based on research about steps of a production technology and technological parameters, production cost and crude drug bioavailability. With the adoption of the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism, the defects of tedious processing procedure, long production period, high manufacturing cost, low crude drug bioavailability and higher toxic or side effects in the prior art are overcome.

The invention relates to a method for synthesizing pidotimod, which comprises the following steps of: mixing L-thiazolidine-4-carboxylic acid and an acid binding agent in anhydrous acetone; dripping an anhydrous acetone solution of L-pyroglutamic acyl chloride; after the reaction is finished, filtering; dissolving a filter cake in water, acidifying, and filtering to obtain a coarse product; and drying the coarse product, and recrystallizing to obtain the pidotimod.

The invention discloses a larimichthys crocea hemoglobin antibacterial peptide (LCH4). The amino acid sequence of the larimichthys crocea hemoglobin antibacterial peptide is AWQKFLSAVVSALGR, and the molecular weight of the antibacterial peptide is 1633Da. The invention also discloses an application of the larimichthys crocea hemoglobin antibacterial peptide in preventing or inhibiting bacteria such as staphylococcus aureus, escherichia coli, streptococcus iniae and the like. The invention lays a foundation for subsequent further research on development of the larimichthys crocea hemoglobin antibacterial peptide as a food preservative and a feed additive for preventing fish diseases.

The invention provides a Chinese and western medicine composition for treating canine parvovirus infection and a preparation method thereof. The composition contains the following ingredients in portion by weight: 15-30 portions of radix puerariae, 15-30 portions of rhizoma coptidis, 15-30 portions of radix scutellariae, 15-30 portions of phellodendron, 15-30 portions of rhubarb, 15-30 portions ofChinese pulsatilla root, 15-30 portions of sanguisorba, 15-30 portions of alisma orientale, 15-30 portions of radix paeoniae alba, 30-40 portions of myrobalan and 2-5 portions of ofloxaction. The preparation method comprises the following steps: putting the Chinese medicinal materials in proportion in water for decocting; standing and collecting supernatant and then concentrating until a relativedensity of the supernatant is 1.0-1.3; then adding alcohol aqueous solution, wherein the volume percentage concentration of the alcohol aqueous solution is 50-80; standing for 24 hours, collecting the filtrate as well as recycling and concentrating the alcohol; and adding the ofloxaction into the concentrated liquid. The Chinese and western medicine composition has low toxicity and can effectively prevent and treat the canine parvovirus infection.