944results about How to "Low toxicity" patented technology

The invention relates to the technical field of antibacterial peptide application, in particular to an antibacterial peptide for inhibiting drug-resistant acinetobacter baumannii as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide is cd77AHP-2, and the amino acid sequence of the antibacterial peptide is shown as SEQ ID NO.1. The antibacterial peptide cd77 obtained through artificial chemical synthesis is modified, distribution of cationic amino acid is optimized, and the antibacterial activity of the antibacterial peptide is remarkably improved. The antibacterial peptide cd77AHP-2 has a remarkable antibacterial effect on acinetobacter baumannii which are gram-negative bacteria and multi-drug resistant acinetobacter baumannii, and the antibacterial peptide cd77AHP-2 has a remarkable antibacterial effect on the acinetobacter baumannii which are gram-negative bacteria. The antibacterial peptide cd77AHP-2 provided by the invention has relatively low cytotoxicity to human bronchial epithelial cells, and has the potential of preparing a drug for resisting drug-resistant acinetobacter baumannii. The invention provides a novel functional polypeptide for the field of antibacterial peptides, and the novel functional polypeptide has important practical application value.

The invention discloses a comprehensive treatment system and treatment method for industrial wastewater containing organic fluorine, electrocatalytic oxidation is carried out through an electrocatalytic oxidation reactor in a physicochemical treatment area, the toxicity of the wastewater containing fluorine is effectively reduced, chain scission is carried out on fluorine-containing organic matter macromolecules, the biodegradability of the wastewater containing fluorine is improved, and the treatment effect is good. The fluorine removal reaction sedimentation tank and the calcium removal reaction sedimentation tank are sequentially adopted to effectively remove most fluorine ions and excessive calcium ions, so that the fluorine ion concentration of the fluorine-containing wastewater reaches 10 mg / L, the biological reaction area and the rear fluorine removal guarantee area are arranged at the rear end, the fluorine ion concentration of effluent is further reduced, fluorine removal is effective, operation is easy and convenient, and the cost is low.

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The preparation method comprises the following steps: mixing saccharomycetes, lactic acid bacteria and bacillus subtilis according to a ratio of 1: 1: 1 to obtain mixed bacteria; 0.25 g of mixed bacteria is taken and dissolved in 5 mL of sterile water for standby application; slicing and crushing the dried rhizoma polygonati, and sieving with a 10-mesh sieve to obtain rhizoma polygonati powder; the preparation method comprises the following steps: mixing water and rhizoma polygonati powder according to a liquid-material ratio of 10mL: 1g, sterilizing at 121 DEG C for 30min, cooling, adding mixed bacteria according to an inoculum size of 3% of the mass of rhizoma polygonati, culturing in a constant-temperature shaking table incubator at 120r. Min <-1 > for 72h at the culture temperature of 035 DEG C, sterilizing at 100 DEG C for 30min after fermentation, cooling and centrifuging to obtain rhizoma polygonati fermentation liquor, and storing at 4 DEG C. The prepared polygonatum sibiricum fermentation liquor is high in active ingredient content, has good cell safety, anti-oxidation, anti-inflammatory and whitening effects, and has the potential of being used for developing functional raw materials of traditional Chinese medicine cosmetics.

The invention discloses a novel biofilm treatment method for xanthate pollution in flotation wastewater, comprising the following steps: using tailings pond sediments taken from heavy metal mine pollution sites, using selective culture medium to screen and enrich xanthate degradation functional bacteria therefrom, and performing subculture; injecting xanthate functional degradation bacteria into a membrane aeration biofilm reaction system, using mineral processing wastewater containing xanthate as a matrix, passing oxygen-containing gas, and culturing biofilm; when the xanthate concentration in the system effluent of the membrane aeration biofilm reaction system drops below 1.0 mg / L, the enrichment of biofilm is completed; based on the xanthate degradation efficiency of the biofilm under different environmental parameters, determining the optimal operation strategy for the membrane aeration bioreactor system; and based on the optimal operation strategy, passing mineral processing wastewater for in-situ biological treatment, and returning the treated reused water to the mineral processing workshop for reuse. The method is green, environmentally friendly, and economical, does not generate secondary pollution, and efficiently and completely treats xanthate.

The invention discloses a method for targeted creation of a fast-growing new tilapia strain, and belongs to the technical field of fish cultivation. The method specifically comprises the following steps: (1) taking a fragment, as shown in SEQ ID NO.1, on a third exon of a pomc gene as a gRNA target sequence; (2) designing and synthesizing a gRNA primer sequence; (3) amplifying by adopting the gRNA primer sequence and the gRNA plasmid, and then transcribing and purifying to obtain a gRNA fragment; (4) transferring the gRNA fragments into fertilized eggs of tilapia mossambica through gene editing to obtain F0-generation positive fish; and (5) hybridizing the F0-generation positive male fish with the wild-type female fish, screening out F1-generation parent fish, and culturing the F1-generation parent fish to obtain F2-generation tilapia with homozygous deletion mutation. According to the invention, the pomc homozygous knockout line is established in the Nile tilapia mossambica for the first time, the new fast-growing line is a complete gene function deletion model, the cost is lower, the efficiency is higher, and the phenotype can be stably inherited.

The invention provides a compound phospholipid gel sustained release preparation and a preparation method thereof. The preparation mainly comprises a local anesthetic, a non-steroidal anti-inflammatory drug, phospholipid and water for injection. The preparation can be injected around a surgical incision or directly instilled or coated at the surgical incision to achieve the purpose of long-acting analgesia, and is used for postoperative analgesia.

The invention discloses application of a low-toxicity broad-spectrum antibacterial peptide taking WW as a symmetric center, WK is repeated twice and symmetrically distributed on two sides, WW is taken as the symmetric center to obtain an antibacterial peptide WKWKWWKWKW-NH2 (N2W2), and tryptophan at the C terminal and the N terminal of the N2W2 is replaced with leucine and / or isoleucine to obtain the antibacterial peptide. The antibacterial peptide can basically maintain the excellent antibacterial activity of the parent peptide, and the hemolytic activity of the antibacterial peptide is greatly reduced, so that the safety is improved. Wherein the antibacterial activity of IL-N2W2 is the highest, but the stability of IL-N2W2 needs to be improved, so that D-IL-N2W2 is obtained by carrying out D-type amino acid substitution on IL-N2W2. The D-IL-N2W2 keeps the high antibacterial activity and low toxicity of IL-N2W2, can still completely inhibit the growth of bacteria after being incubated with high-concentration trypsin or chymotrypsin, has great potential in the aspect of relieving the drug resistance of antibiotics, and has good application prospects in preparation of clinical antibacterial drugs.

The invention discloses a PARP1 / CDK6 double-target inhibitor as well as a preparation method and application thereof, the PARP1 / CDK6 double-target inhibitor is selected from a compound with a structure as shown in a formula I or pharmaceutically acceptable salt or solvate thereof, L is selected from # imgabs0 #, and R is selected from hydrogen, deuterium, halogen, hydroxyl, sulfydryl, cyano, nitro, methoxyl, C1-C8 alkyl or C3-C8 cycloalkyl. The PARP1 / CDK6 double-target inhibitor disclosed by the invention has a relatively good effect on human breast cancer cells, and keeps good in-vitro enzyme inhibition activity on CDK6 and PARP1. The invention discloses an application of a CDK6 / BRD4 double-target inhibitor in preparation of a medicine for treating PARP1 / CDK6 mediated diseases. The invention discloses an application of a PARP1 / CDK6 double-target inhibitor in preparation of a medicine for treating or preventing triple negative breast cancer. # imgabs1 #

The invention discloses a preparation method and application of a manganese-based amino acid coordination polymer, and belongs to the technical field of nano-enzymes and nano-drugs. Divalent manganese salt, histidine and other amino acids are subjected to a co-precipitation reaction to prepare the manganese-based amino acid coordination polymer, and the polymer is of a nanoparticle structure, small in size and high in stability, has enzyme-like activity, catalyzes hydrogen peroxide to generate high-toxicity hydroxyl free radicals and is used for specifically killing tumor cells. The catalyst has the capability of catalytically generating singlet oxygen in the presence of hydrogen peroxide. Meanwhile, the manganese-based amino acid complex has glutathione oxidase-like activity, consumes glutathione to overcome the resistance of tumors to oxidative stress, improves the chemical kinetic curative effect, and has anti-tumor application potential.

The invention belongs to the field of comprehensive utilization of plant resources, and relates to a method for extracting amide components in Chinese prickly ash through a natural eutectic solvent assisted by superfine grinding. The method comprises the following steps: firstly, collecting a pepper raw material, drying the pepper raw material by a heat pump, and performing high-speed crushing and low-temperature superfine crushing to obtain pepper superfine powder; preparing a natural eutectic solvent from a hydrogen bond acceptor and a hydrogen bond donor, mixing the natural eutectic solvent with the pepper superfine powder, performing microwave-assisted extraction, centrifugally collecting supernate after extraction, and completing primary extraction; adding NDES into the remaining precipitate, and repeatedly extracting according to the primary extraction step; and repeatedly extracting for several times, combining the supernate, and finally concentrating and filtering with a filter membrane to obtain an extracting solution, thereby realizing the extraction of the amide components in the Chinese prickly ash. The method provided by the invention overcomes the defects of low extraction efficiency, environmental pollution caused by an extraction reagent, high equipment cost and the like in the existing technical means for extracting the amide components in the Chinese prickly ash, realizes efficient and green extraction of the amide components in the Chinese prickly ash, and has a wide application prospect.

The invention discloses a cryopreserved dental sac mesenchymal stem cell injection as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The cryopreserved dental sac mesenchymal stem cell injection comprises a cryopreservation protection solution and human dental sac mesenchymal stem cells MSC with the preservation number of CCTCC NO: C2024384, wherein the cryopreservation protection solution comprises 8 to 12 parts of human serum albumin, 35 to 45 parts of a sodium chloride injection and 45 to 55 parts of a CryoStorCS10 cell cryopreservation solution; the density of the dental sac mesenchymal stem cells is 0.5 * 10 < 7 >-20 * 10 < 7 > cells / mL. The invention further discloses a preparation method of the injection and application of the injection in preparation of drugs for preventing or / and treating periodontal diseases. The injection can be directly used after being unfrozen, can maintain the activity and the biological performance of the dental sac mesenchymal stem cells, enhances the osteogenesis and cartilage formation capabilities of the dental sac mesenchymal stem cells, and has a good effect of treating periodontal diseases.

The invention belongs to the technical field of biomedical high-molecular polymer materials, and discloses a pH and temperature dual-response lignin-based amphiphilic polymer and micelle as well as a preparation method and an application of the pH and temperature dual-response lignin-based amphiphilic polymer and micelle. The preparation method of the polymer comprises the following steps: purifying the alkali lignin, preparing a macroinitiator AL-Br based on the alkali lignin, and then preparing the lignin-based amphiphilic polymer with double responses of pH and temperature. The polymerization process is controllable, and the usage amount of copper is lower than 500 ppm. The lignin polymer disclosed by the invention can be self-assembled into nano-scale micelles in a water medium, the structure is stable, and AgNPs and an entrapped hydrophobic anticancer drug CPT can be simultaneously prepared in situ. The obtained single nano-carrier system has good silver nanoparticle stabilizing capacity, in-vitro pH and temperature double-response drug release capacity and excellent cytotoxicity and antibacterial capacity, can achieve the anti-tumor and antibacterial purposes at the same time, and is well applied to preparation of drugs with anti-tumor and antibacterial effects at the same time.

The invention discloses a preparation method of a multifunctional polyvinyl composite film and application of the multifunctional polyvinyl composite film in food preservation. The preparation method comprises the following steps: firstly, preparing Ag-coated MOF through a hydrothermal method, then uniformly dispersing the Ag-coated MOF and tannic acid into a carboxymethyl chitosan solution, and carrying out crosslinking modification on the Ag-coated MOF; and coating the prepared CMCS / TA / Ag (at) MOF mixed solution on a polyethylene film treated by oxygen plasma, and drying to form a film, so as to obtain the multifunctional polyethylene-based composite film. The CMCS and the TA are adopted to perform crosslinking modification on the Ag-coated MOF, so that the stability of the Ag-coated MOF can be further improved, and the release of silver ions is reduced. Compared with a common PE preservative film, the composite film prepared on the basis has better barrier capacity and mechanical property, and has antibacterial, anti-ultraviolet and anti-oxidation effects. The multifunctional preservative film is convenient to use and low in price, and has an important application prospect in the aspect of fresh-keeping packaging of meat products.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses a pesticide residue scavenging agent. The feed additive is prepared from the following components in parts by weight: 90-110 parts of white hyacinth beans, 9-11 parts of papain, 90-110 parts of liquorice, 45-55 parts of folium isatidis, 25-35 parts of perilla leaves, 25-35 parts of fructus forsythiae, 25-35 parts of honeysuckle, 15-25 parts of rhizoma smilacis glabrae, 15-25 parts of ginkgo leaves, 4-6 parts of soybean protease, 9-11 parts of glutathione, 5-7 parts of amino-oligosaccharin, 9-11 parts of amylase and 7-9 parts of walnut peptide. The invention also discloses a preparation method of the pesticide residue scavenger. The method has the following outstanding effects: the method is easy to operate, low in cost, popular in price and remarkable in effect, and can reach the national safety agricultural product indexes.

The invention relates to the field of hydrogel materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The deferoxamine mesylate is loaded on the gelatin microsphere material constructed by the gelatin and the genipin, so that the loading dispersion of the deferoxamine mesylate can be benefited, and the added gelatin can be in contact with matrix proteinase-9 in a diabetic foot ulcer microenvironment for degradation so as to induce the release of the deferoxamine mesylate. A first cross-linked network is formed by the 3-carboxyphenylboronic acid modified chitosan and the oxidized hyaluronic acid, and the gelatin microsphere material loaded with the deferoxamine mesylate and the epigallocatechin gallate are coated with the first cross-linked network. The hydrogel dressing realizes controllable release of the deferoxamine mesylate and the epigallocatechin gallate, so that the technical problem of uncontrollable release of the deferoxamine mesylate is solved.

The invention discloses a low-shrinkage creep-resistant plastic-wood product and a preparation method thereof, and belongs to the technical field of plastic-wood composite materials. The composite material is prepared from the following raw materials in parts by weight: 10 to 18 parts of polypropylene, 22 to 35 parts of high-density polyethylene, 58 to 83 parts of eucalyptus / walnut shell / montmorillonite composite modified powder, 10 to 15 parts of hydroxyl-terminated polybutadiene and graphene / ZnO2 / CaO, 7 to 15 parts of basic magnesium sulfate whisker, 3 to 4.6 parts of gamma-glycidyl ether oxypropyl trimethoxy silane and 0.3 to 1 part of antioxidant. In this way, the plastic-wood product is high in low-temperature impact strength, good in creep resistance, small in linear thermal expansion coefficient and high in thermal deformation temperature. Specifically, the impact strength of the plastic-wood product is 6.96-7.27 KJ / m < 2 >; the tensile creep modulus is 18.8 to 21.6 Mpa; the linear thermal expansion coefficient is 2.5-3.1 * 10 <-5 > / DEG C; the thermal deformation temperature is 163.2 to 178.5 DEG C;

The invention relates to the technical field of immunochromatography, in particular to a silicon-coated color fluorescent microsphere and a mild preparation method and application thereof.The preparation method comprises the steps that firstly, time-resolved fluorescent dye is synthesized in an ethanol system, then oil-soluble dye, an ethanol water solution and a swelling agent dichloromethane are added, stirring is conducted at the room temperature to enable the dye to be dissolved, and then the silicon-coated color fluorescent microsphere is obtained; and adding ammonia water and a silane coupling agent tetraethyl orthosilicate, reacting overnight, supplementing the ammonia water, gradually adding a coupling agent 3-aminopropyltriethoxysilane, and washing with pure water for several times after the reaction is finished. The particle size range of the prepared color time-resolved fluorescent microspheres is 200-450 nm, the color time-resolved fluorescent microspheres are prepared in a green and mild mode through a one-step method, a surface active agent, a dispersing agent and a surface amino modified silicon dioxide matrix are not used, the high-luminous-intensity binuclear rare earth europium complex and the oil-soluble dye are embedded into the microspheres in the polymerization process, the dye is not prone to leakage, and the color time-resolved fluorescent microspheres are environmentally friendly and environmentally friendly. The method can be used for qualitative and quantitative dual immunodetection in the field of immunochromatography.

The invention discloses an environmentally friendly high-elastic polyurethane modified acrylic runway surface adhesive and a preparation method thereof, which solves the problems of insufficient compatibility and mechanical strength of a plastic runway prepared by using organosilicon modified polyurethane in the existing process, and easy shedding or stratification when the organosilicon is compounded with the polyurethane. The runway surface adhesive is composed of the following raw materials: water-based polyurethane emulsion, modified acrylate, modifier, flame retardant, antioxidant, crosslinking agent, auxiliary foaming agent and white oil. The invention provides an environmentally friendly high-elastic polyurethane modified acrylic runway surface adhesive, which uses water-based polyurethane emulsion and modified acrylate as base materials, and the method of modifying the water-based polyurethane emulsion by modified acrylate is more environmentally friendly, while the modifier in the raw materials ensures that the runway surface adhesive has high elasticity and crosslinking density, and the modifier and the auxiliary foaming agent cooperate with each other to significantly improve the foaming effect of the plastic runway, and help to generate uniform and dense bubbles inside the runway surface adhesive material.

The invention discloses a preparation method and application of stimuli-responsive wide-gamut color-changing phosphorescent carbon dots, and the preparation method comprises the following steps: S1, at 180-250 DEG C, taking levofloxacin and acid as reaction raw materials, and carrying out hydrothermal reaction in an aqueous solution for 1-8 hours; s2, cooling a reaction product obtained by the hydrothermal reaction, and performing centrifugal separation to obtain a reactant solution; and S3, drying the obtained reactant solution to obtain the stimuli-responsive wide-color-gamut color-changing phosphorescent carbon dots. The preparation method of the stimuli-responsive wide-gamut color-changing phosphorescent carbon dots is simple, the raw materials are wide in source and easy to obtain, the reaction conditions are mild, the yield is high, and the carbon dots are green, pollution-free, low in toxicity and suitable for batch production; the stimuli-responsive wide-color-gamut color-changing phosphorescent carbon dot material fills the blank of wide-color-gamut color-changing phosphorescent carbon dot materials, solves the problem that stimuli-responsive wide-color-gamut color-changing phosphorescent carbon dots are difficult to prepare, and can be used for phosphorescent color display, advanced information encryption and food freshness monitoring.

The invention discloses application of a plant extract in preparation of a drug for resisting canine coronavirus, and relates to the technical field of biological medicine. Research finds that plant extracts-shikimic acid, phloretin, caffeic acid, tribulus terrestris saponin, berberine hydrochloride and apple polyphenol have activity of resisting canine coronavirus, wherein the effect of phloretin is most remarkable. The phloretin has antiviral activity in three aspects of direct killing, inhibition of virus adsorption and inhibition of virus growth, wherein the effect of inhibiting virus growth is most significant. And the EC50 of the phloretin acting on the CCoV is 0.616 mg / L. The plant extract provided by the invention is derived from natural plants, and has the advantages of low toxicity and good biocompatibility compared with chemical drugs. The invention provides a technical support for developing a novel, effective, safe and side-effect-free medicinal preparation for preventing and treating canine coronavirus.

The invention discloses a preparation method, a use method and application of a composite soil conditioner, and relates to the technical field of soil remediation. Compared with the prior art, the composite soil conditioner is prepared by uniformly mixing calcined oyster shells and limestone with biochar, organic activated carbon and mineral source humic acid; the composite soil conditioner is simply applied to arsenic-polluted soil, and can improve the soil structure, improve the composition of organic matters in the soil, increase the Eh value of crop rhizosphere soil and increase the biomass of crops, so that the soil quality is improved. The biological availability and toxicity of arsenic are remarkably reduced through multiple effects of soil in-situ passivation, iron-arsenic precipitation forming, iron film / titanium film forming and the like, the content of arsenic absorbed and accumulated at edible parts of stems and leaves of crops is reduced, arsenic is intercepted at unedible root parts, solid waste resource utilization is achieved, and the method is low in cost and environmentally friendly.

The invention belongs to the technical field of photoinitiators, and particularly relates to a ketoxime ester photoinitiator as well as application and a photosensitive combination thereof. Compared with the prior art, the novel photoinitiator has the advantages that by introducing a sulfone phenyl specific structure to a ketoxime ester group and the like, excellent photosensitivity can be shown in the optical wavelength range of 280-400 nanometers, and compared with OXE-01 and OXE-02 commonly used in the market, the novel photoinitiator can show better photoinitiation efficiency under an ultraviolet visible (UV-Vi s) LED light source.

The invention belongs to the field of drug-loaded nanoparticles, and provides a targeted drug-loaded nanoparticle with multiple responsiveness and a preparation method thereof. The targeted drug-loaded nano-particle with multiple responsiveness is prepared from poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel with temperature and pH response characteristics, an anti-tumor drug and a folic acid layer capable of specifically targeting a folic acid receptor of a tumor cell, wherein the temperature and pH response characteristics are realized by the poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel; the anti-tumor drug is loaded in the polymer network structure of the nanogel to form drug-loaded nanoparticles, the folic acid layer is composed of aminated folic acid molecules, the folic acid layer coats the drug-loaded nanoparticles, and amino groups of the aminated folic acid molecules are grafted on the surfaces of the drug-loaded nanoparticles. According to the invention, the preparation method of the existing chemotherapy nano-drug carrier can be simplified, the controllability of the preparation process is improved, the biocompatibility of the existing chemotherapy nano-drug carrier is improved, and the targeting property of the existing chemotherapy nano-drug carrier is enhanced.

The invention relates to the field of application of medicines for treating rheumatoid arthritis, and discloses an application method of targeted MTHFD2 in preparation of medicines for treating bone destruction of rheumatoid arthritis, (1) the level of MTHFD2 in knee joints of rheumatoid arthritis patients and mice is increased; (2) the expression of MTHFD2 is up-regulated in the process of differentiating osteoclast precursor cells from mice and humans into osteoclasts; (3) the MTHFD2 inhibitor can significantly inhibit differentiation of osteoclasts from mice and humans; (4) MTHFD2 gene silencing can inhibit differentiation of mouse-derived osteoclasts, MTHFD2 gene overexpression can promote differentiation of osteoclasts, and reliability of MTHFD2 as a therapeutic target is verified; and (5) the MTHFD2 inhibitor can improve the bone destruction of arthritis mice and increase the bone tissue density, which prompts that the targeted MTHFD2 is useful for the treatment or prevention of rheumatoid arthritis and other diseases.

The invention relates to the technical field of waste battery recovery and regeneration, in particular to a deep eutectic solvent, a waste battery negative electrode graphite recovery and regeneration method and a regenerated graphite material. The deep eutectic solvent is composed of a hydrogen bond acceptor and a hydrogen bond donor, the hydrogen bond acceptor is choline chloride, and the hydrogen bond donor is phytic acid. The method comprises the following steps: pretreating the waste lithium battery to obtain a waste graphite material; leaching the waste graphite material by using a deep eutectic solvent, and then washing and drying to obtain regenerated graphite; the deep eutectic solvent is a combination of choline chloride and phytic acid. The method provided by the invention has the advantages of low toxicity of raw materials, low corrosivity and environmental friendliness; metal in the waste graphite is effectively removed, phosphorus is doped, and the lithium storage performance of the graphite is improved while the graphite is repaired; the regeneration temperature is low, and a low-energy-consumption and low-acidity scheme is provided in the aspects of treatment and regeneration of the waste graphite.

The invention discloses a lactam ring compound and application thereof, and belongs to the technical field of chemical medicines. The lactam ring compound as shown in the formula I provided by the invention can be used as a PARP1 inhibitor, has the advantages of high activity and high selectivity, and also has excellent pharmacokinetic properties and safety. # imgabs0 #

The invention relates to hydrogel containing all-type sun-screening agent microbeads, a preparation method and application, and belongs to the technical field of sun screening. Mixing, heating and dissolving the oil-soluble organic sun-screening agent to obtain the sun-screening oil; the preparation method comprises the following steps: mixing a sodium alginate solution, a PVA solution and an inorganic sun-screening agent (zinc oxide and titanium dioxide) to form a turbid liquid, and uniformly stirring to form a first mixture; preparing oil-in-water microspheres from the obtained sunscreen oil and the first mixture through a microfluidic technology, and dripping the oil-in-water microspheres into a calcium chloride solution to form light yellow sunscreen microspheres; adding carbomer sodium into water to form gel, then adding the water-soluble organic sun-screening agent, adding the pH regulator while heating and dissolving until the solution is transparent, then adding the active substance, and continuously stirring until the mixture is uniformly mixed to obtain a third mixture; adding a thickening agent to prepare hydrogel; and adding the sunscreen microbeads into the hydrogel to obtain a dispersion system containing all types of sunscreen microbeads. The invention solves the technical problem that the product in the existing sunscreen system is greasy and easily causes anaphylactic reaction.

The invention discloses an activation method of silicon malachite minerals and a flotation method of high-alkalinity copper oxide ore or copper cobalt oxide ore, and belongs to the technical field of ore dressing. According to the method, crystalline phase transformation and site reconstruction are carried out on the surface of the silicon malachite, so that the surface of the silicon malachite is activated to enhance the flotation separation effect of the silicon malachite, and the problem that the silicon malachite is difficult to float and recover due to high surface hydrophilicity is solved. The method for activating the silicon malachite can also be used for flotation of complex high-alkalinity copper oxide (or copper-cobalt) ore, the high-alkalinity copper oxide (or copper-cobalt) ore is treated through the positive and negative combined flotation process, and the purposes that the recovery rate of copper and cobalt in the high-alkalinity copper oxide (or copper-cobalt) ore is larger than 90%, and the removal rate of calcium and magnesium is larger than 70% can be achieved. Compared with an existing copper oxide (copper-cobalt ore) flotation process, the method has the advantages of being simple in process, high in adaptability, small in toxicity, low in cost, high in economic benefit and easy to industrially popularize and apply.