279results about How to "Low toxicity" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention discloses an ROS-responsive prostate cancer targeting prodrug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The prodrug is formed by covalently linking a prostate cancer targeting peptide SYEELR, a ROS (reactive oxygen species) response type ketal thiol (TK) connexon and an active molecule Devimistat. The preparation method comprises the following two steps: firstly, coupling Devimistat with a TK linker to obtain an intermediate Dev-TK, and then coupling the intermediate Dev-TK with an SYEELR peptide fragment to obtain a target product. The prodrug can specifically break and release Devimistat in a tumor high active oxygen microenvironment, and active targeting delivery is realized by virtue of the SYEELR peptide. The invention provides a novel prostatic cancer treatment strategy with accurate targeting, controllable release, enhanced curative effect and toxicity reduction potential.

This invention discloses a copper-based ternary chalcogenide semiconductor material, its preparation method, and its applications. The material is prepared by mixing CuSn(OH)6 nanomaterials, thioacetamide, ethylenediaminetetraacetic acid, and water and carrying out a hydrothermal reaction to obtain Cu3SnS4 nanomaterials. This semiconductor material exhibits excellent photoelectrochemical properties. Photoelectrochemical sensors constructed based on this material demonstrate high detection accuracy, fast response speed, low detection limit, and strong stability, enabling rapid and accurate real-time detection of microplastic content. The preparation method is simple, low-cost, and suitable for industrial production.

This invention provides an application of the peptide Nod-T3 in the preparation of drugs for treating lung diseases. The Nod-T3 peptide is derived from human protein and has a significant inhibitory effect on chronic lung inflammation and fibrosis caused by smoking. It can be used to treat COPD and other smoking-related lung diseases. It also has high biocompatibility and low toxicity, and has the potential and development value to become a new type of peptide drug.

The application discloses a blood perfusion adsorbent for removing endotoxins and free radicals, and a preparation method and application thereof. The adsorbent (P-PEI Cu / TA) has simple preparation process, low cost, good blood compatibility, endotoxin adsorption performance and the ability of removing free radicals generated by oxidative stress, can remove endotoxins in blood of patients with sepsis, and remove free radicals generated by oxidative stress caused by endotoxins. The development of the blood perfusion adsorbent of the application is helpful to extracorporeal blood perfusion treatment of patients with sepsis and reduction of medical cost.

The present application relates to the field of environmental protection, and particularly to a technology for disposing of wind power generation scrap materials by using industrial kiln; the organic metal catalytic adsorption filler prepared by the present application is used for adsorbing dioxins in flue gas; through catalytic reaction, the dioxins are converted into more harmless or more easily handled compounds, so as to reduce the content; at the same time, the adsorption effect can also help to remove dioxins from the flue gas; such conversion includes breaking of chemical bonds, rearrangement or change of functional groups, etc.; through these changes, the toxicity and stability of dioxins are reduced, so that they are more easily handled or degraded; at the same time, due to the adsorption effect, the dioxins are fixed on the catalyst or adsorbent, so as to be effectively removed from the flue gas; the present application has simple process, small investment, low cost and high economy, and industrial waste such as plastic, rubber, tire, etc. is used as combustion-supporting material.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The invention belongs to the field of microbial fermentation and the technical field of daily chemicals, and particularly relates to deacetylated sophorolipid as well as a preparation method and application thereof. By using cheap culture medium components and screening out saccharomycetes with high yield of lactone type sophorolipid, the problem that the production cost of the sophorolipid is too high is effectively solved, and the application of the sophorolipid in various fields is promoted; through the step of carrying out enzymolysis on a fermentation substrate in advance, the problems of long single fermentation period, low thallus utilization rate, high energy consumption and high cost of traditional saccharomycetes are solved. A multi-round fermentation circulation system is designed, and bacteria liquid is settled and recycled and then inoculated and fermented, so that thalli are efficiently and repeatedly utilized, the unit yield is increased, the fermentation period is shortened, and the production cost is effectively controlled. The structure is adjusted through a resin modification technology, a final product mainly comprises acetylated sophorolipid, and compared with acetylated sophorolipid and deacetylated sophorolipid, the sophorolipid has better foam stability and sensitive skin repairing effect and is suitable for the application fields of cosmetics, washing care and the like.

The application discloses an electrolytic catalytic biological denitrification reactor and relates to the technical field of sewage treatment. The electrolytic catalytic biological denitrification reactor comprises a reactor body, an external power supply connected to the reactor body, an anaerobic reaction chamber and an aerobic reaction chamber separated by a first partition wall in the inner cavity of the reactor body, and a first drainage hole formed in the first partition wall. A water inlet is formed in the outer side wall of the anaerobic reaction chamber. A unit cathode and a water flow propeller are fixed in the anaerobic reaction chamber. A water outlet is formed in the outer side wall of the aerobic reaction chamber. A unit anode and a water flow propeller are fixed in the aerobic reaction chamber. The unit anode and the unit cathode are connected in parallel through wires, and the wires are connected to the external power supply. The electrolytic catalytic biological denitrification reactor can effectively improve the biological denitrification efficiency, reduce the pollution to the environment, has strong adaptability to water quality changes, has good sludge settling performance, is easy to maintain, manage and operate, has high denitrification efficiency, and has small land occupation.

The application relates to a YAG / Yb:YAG / YAG composite laser transparent ceramic and a preparation method thereof. The Yb:YAG water-based ceramic ink comprises mixed powder composed of Al2O3 powder, Y2O3 powder and Yb2O3 powder, the solid content is 20-25 vol%, the mole ratio of Al2O3, Y2O3 and Yb2O3 is 5:3-x:x, and 0 < x <= 0.3; the dispersant content is 0.2-0.8% of the mass of the mixed powder; the pH control agent is used in an amount controlled to adjust the pH of the Yb:YAG water-based ceramic ink to be between 10-11.5 and the pH of the ink is greater than or equal to 9.5 within 24 hours under the conditions of sealing and 20-25 DEG C; the humectant content is 5-20% of the total volume of the Yb:YAG water-based ceramic ink; the binder content is 0.1-0.5% of the mass of the mixed powder; and the sintering aid content is 0.1-0.5% of the mass of the mixed powder.

This invention belongs to the fields of fermentation engineering and enzyme engineering technology, specifically relating to a chitosanase fermentation method based on a Pichia pastoris expression vector and its application. The chitosanase fermentation method provided by this invention includes two stages: fermentation during the cell growth phase and fermentation during the induction phase, with strict control over the carbon source and specific feeding method at each stage. During fermentation, this invention significantly improves the expression level and absolute enzyme activity of chitosanase Baa by adding casein hydrolysate as a molecular chaperone, mannitol as an adjuvant, and further optimizing the carbon source feeding strategy and parameters such as pH and temperature. Compared with the starting process, this invention increases the chitosanase activity by 1.81 times and the protein expression level by 2.01 times. Moreover, the fermentation method of this invention has been successfully verified in a 50L pilot-scale operation, demonstrating a good foundation for industrial application and cost advantages.

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The invention relates to the technical field of phenolic resin, in particular to dialdehyde cellulose-based phenolic resin and a preparation method thereof. The dialdehyde cellulose-based phenolic resin is prepared from dialdehyde cellulose, phenol, formaldehyde and a basic catalyst. According to the invention, the dialdehyde cellulose prepared from renewable biomass resource cellulose is used for replacing part of formaldehyde to prepare the dialdehyde cellulose-based phenolic resin, so that the use amount of formaldehyde can be reduced by 20%, and the production cost and material toxicity of the phenolic resin are reduced. Meanwhile, the dialdehyde cellulose-based phenolic resin prepared by the method disclosed by the invention has excellent bonding performance and thermal stability. Technical support is provided for solving the problems that biomass components are difficult to utilize, phenolic resin raw materials excessively depend on non-renewable resources, the bonding performance is not ideal and the like, and great application and popularization value is achieved.

The invention provides a green, environment-friendly, efficient and mild detergent and a preparation method and application thereof, and belongs to the technical field of detergents. Comprising the following raw materials in parts by weight: 10 to 20 parts of a mild surfactant, 5 to 8 parts of an auxiliary surfactant composition, 1 to 2 parts of a plant extract, 0.5 to 1 part of vitamin C, 0.1 to 0.3 part of vitamin E, 0.2 to 0.5 part of vitamin B5, 0.005 to 0.007 part of essence, 0.1 to 0.3 part of EDTA (Ethylene Diamine Tetraacetic Acid) disodium and 60 to 80 parts of deionized water. The prepared green, environment-friendly, efficient and mild detergent is good in foaming effect, stable in chemical property, mild, low in toxicity, good in washing effect and good in degradability, due to addition of the auxiliaries, the sense of the detergent is smoother, the fragrance of the detergent is more loved, and the detergent has wide application prospects.

This invention relates to the field of medical biopolymer materials technology, specifically to an injectable hydrogel for kidney stone removal, its preparation method, and its application. The preparation materials include at least a precursor solution 1 and a precursor solution 2. Precursor solution 1 contains at least a polyethylene glycol derivative and a thickener, while precursor solution 2 contains at least a polyamino polymer. By optimizing the formulation ratio of the two-component precursor solutions, a hydrogel with strong conformability, good toughness, and viscosity is formed in situ in the kidney stone area. This encapsulates the kidney stone, facilitating its removal from the body and avoiding the safety hazards associated with small kidney stone fragments or conventional drug treatment.

The present application relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a tea-substitute formula for treating insomnia in young and middle-aged people, which comprises the following steps: crushing fried jujube seeds, cleaning and draining dried yam, dried red mulberry and mixing them, mixing and stirring the plant lactobacillus powder and the medicinal materials, constant temperature fermentation and low temperature drying after sealing, coarse grinding after drying, mixing with sweet hibiscus and sweet marigold to obtain the tea-substitute formula. The tea-substitute formula for treating insomnia in young and middle-aged people and the preparation method thereof mainly use fried jujube seeds to nourish the heart and calm the nerves, yam to calm the heart and calm the nerves, and fuling to invigorate the spleen and calm the heart as auxiliary, and combine dried red mulberry to nourish yin and tonify blood, sweet hibiscus to relieve depression and calm the nerves, and sweet marigold to harmonize the taste, so as to regulate the balance of neurotransmitters from multiple targets, regulate sleep as a whole, and use the enzymes produced by microorganisms to destroy the cell wall of traditional Chinese medicine, so as to effectively improve the dissolution rate and biological conversion rate of sleep-aiding effective components such as jujube saponin and lily alkaloids.

This invention relates to the field of biotechnology, and more particularly to a mutant of the Rift Valley fever virus L protein and its applications. The amino acid sequence of the mutant is based on the amino acid sequence shown in SEQ ID NO:1, with mutations made at position 1189 (aspartic acid) and / or position 1205 (tryptophan). Through cryo-electron microscopy structural analysis and in vitro mismatch experiments, this invention has confirmed that both identified key amino acid sites are involved in regulating the synthetic fidelity of viral polymerase: mutation at N1189 decreases the synthetic fidelity of the polymerase, while mutation at W1205 increases it. This invention not only provides a new target for the development of attenuated vaccines but also provides crucial evidence for elucidating the molecular regulatory mechanisms of RNA virus fidelity.

This invention discloses a method for preparing and applying an antibacterial composite coating based on quaternized zinc oxide nanoparticles. The preparation method includes: grafting quaternary ammonium salt compounds onto the surface of zinc oxide nanoparticles to prepare synergistic antibacterial nanoparticles; modifying the substrate surface by co-deposition of dopamine and polyethyleneimine to introduce active functional groups; and spraying or dipping the quaternized zinc oxide nanoparticles onto the modified substrate surface to obtain the antibacterial composite coating. This novel antibacterial material preparation scheme can integrate the advantages of zinc oxide nanoparticles and quaternary ammonium salts, while solving key technical problems such as nanoparticle aggregation, weak interfacial bonding, and limited antibacterial efficiency. It is of great significance for promoting the upgrading of hygiene and safety in the fields of medicine, food, and building materials.

The application discloses a composite flocculant based on aluminum chloride and a preparation method thereof, and belongs to the technical field of flocculant preparation, and is used for solving the technical problem that the stability and flocculation performance of the flocculant need to be further improved in the prior art; the branched polymer containing polycarboxyl groups is prepared by the reaction of tris(2-aminoethyl)amine and pyromellitic dianhydride, and the taurine groups are introduced to obtain the sulfobranched polycarboxyl polymer; the titanium phosphorus silicon aminopropyl composite is synthesized by using the sol-gel method, and the inorganic-organic network combination is realized; the polyimidazolium-hydroxy ether is obtained by the reaction of imidazole, epichlorohydrin and bisphenol A diglycidyl ether; the composite flocculant is formed by the reaction of the three under the acidic condition, the composite flocculant combines the polycarboxyl groups, the sulfonic acid groups, the imidazolium groups and the inorganic-organic skeleton, has high charge density, good adsorption and bridging performance, can rapidly form stable flocs, and can effectively remove the suspended particles and organic pollutants in water.

DEPCT6315 / 05 / 2562 This patent application relates to novel derivatives of chlorine E6 and its salts that have been Pharmaceutical acceptance, as well as its preparation and use, are matters of medicine. The amino acid derivative chlorine E6 ether comprises the general structural formulas I and optical. Its isomer, the process for its preparation, consists of the etherification of 3-vinyl in chlorine. RinE6 ether peptides are produced from 15-carboxyl ethyl and amino acid derivatives. Chlorin-E6 ether and its salts are pharmaceutically recognized and can be used as medicine. Antitumor activity by photodynamic means compared to the photosensitizer thalaporfin used in... A similar clinical trial previously conducted on the amino acid derivative chlorine E6 ether of this patent application has... Enhanced photodynamic antitumor activity and dark toxicity ratio. -High photosensitivity, a novel photodynamic antitumor drug prepared includes: Photodynamic anticancer drugs are used to treat non-vascular tumors. Severe photodynamic diseases such as macular degeneration and subdural hemorrhages can occur. Age-related skin conditions and a photodynamic treatment for genital warts. (chemical formula) (I) ----------------------------------------------------------- DEPCT63 Current applications involve novel derivatives of chlorine E6 and its pharmaceutically recognized salts. The science, as well as its preparation and medical applications, are related to the amino acid derivative chlorine E6E. The ther consists of a general structural formula I and its optical ishomer; the preparation process involves etherification. The peptide is produced from 15-carboxyethyl and amino acid derivatives in chlorine-E6 ether. Nochlorine E6 ether and its salts are pharmacologically recognized and can be used as antitumor drugs. The photodynamic method, when compared to the photosensitizer thalaporfin previously used in treatment, utilizes amino acid derivatives. The chlorine-E6 ether currently in use exhibits better photodynamic antitumor activity and a higher toxicity ratio. Dark-induced phototoxicity; a novel photodynamic antitumor drug prepared contains photodynamic antitumor drugs. Photodynamics is a drug used to treat benign vascular tumors such as macular degeneration. It is used for age-related macular degeneration and subcutaneous capillary hypertrophy, and as a treatment for genital warts. The photodynamic method. (chemical formula) (I) -----------------------------------------------------------

Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.

Provided are a compound used as a BCR-ABL inhibitor, namely a compound of formula (I), or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the compound. Moreover, the present invention relates to a use of the compound in the preparation of a drug for treating BCR-ABL related diseases.

The application discloses a multi-strain combined solid-state fermentation rapeseed meal probiotic agent and a fermentation method thereof, adopts Bacillus amyloliquefaciens, Saccharomyces cerevisiae and Bacillus subtilis to combine solid-state fermentation rapeseed meal to reduce the content of anti-nutritional factors such as glucosinolates, and comprises the following steps: pretreatment and sterilization of rapeseed meal raw materials, preparation of fermentation seed liquid, solid-state fermentation of probiotics, and preparation of fermented rapeseed meal products. The application firstly uses Bacillus amyloliquefaciens to solid-state ferment rapeseed meal, and combines with Saccharomyces cerevisiae and Bacillus subtilis to add into rapeseed meal to carry out combined fermentation; compared with other technical solutions, the application can greatly reduce the content of anti-nutritional factor glucosinolate in rapeseed meal, and can reduce the content of anti-nutritional factors tannin, phytic acid and crude fiber in rapeseed meal and improve the content of peptides in the rapeseed meal product, various bioactive substances can be produced in the probiotic fermentation process, and the method has the advantages of low cost, simple operation, short time consumption and high efficiency.

The application discloses a phosphoric acid modified protein or polypeptide, a preparation method thereof and application thereof in vaccines, and belongs to the field of protein phosphoric acid modification. The preparation method of the phosphoric acid modified protein or polypeptide is as follows: a compound containing an aldehyde group and a phosphate group is subjected to nucleophilic reaction with a protein or polypeptide to form a Schiff base; a reducing agent is used to reduce the Schiff base, and after post-treatment, the phosphoric acid modified protein or polypeptide is obtained. After the phosphoric acid modified protein product prepared by the method is prepared into a vaccine with an aluminum hydroxide adjuvant and mice are immunized, the antibody titer is significantly increased. This is of great significance for increasing the immune effect, reducing the inoculation dose, saving the antigen amount and improving the immune response of some people or in specific conditions.

This invention discloses a rapid method for detecting CTCs, belonging to the field of tetracycline detection technology. The invention uses a fluorescence spectrometer to measure the fluorescence intensity of the test solution containing fluorescent probes PEI-CuNCs and a surfactant. Compared with the fluorescence intensity of PEI-CuNCs, if a new blue fluorescence emission band appears at 425 nm and the blue-green fluorescence at 500 nm decreases, then the test solution contains CTCs. The detection method of this invention has advantages such as simple operation, speed, high sensitivity, good selectivity, low detection limit, and low cost. It does not require large-scale instruments or professional operators, and shows good spiked recovery rate in actual water sample testing, with reliable detection results and excellent practicality.

This invention discloses a method for the continuous preparation of biodegradable copolyester PBST. The method includes: (1) esterifying terephthalic acid and 1,4-butanediol in a stirred vertical esterification reactor; (2) introducing the product of step (1), succinic anhydride, and 1,4-butanediol into the stirred vertical esterification reactor for further esterification; (3) introducing the product of step (2) into a pre-polymerization reactor for pre-polymerization; (4) introducing the product from the pre-polymerization reactor into a final polymerization reactor for final polymerization; and (5) introducing the product from the final polymerization reactor into a melt thickening reactor for melt thickening, so that the melt index of the reaction product reaches 1-20. According to the scheme of this invention, not only can high molecular weight aliphatic aromatic copolyesters be continuously prepared, but the tensile mechanical properties of the prepared PBST are also significantly better.

The application belongs to the technical field of biological medicine, and more particularly relates to nanoparticles TK-PSBs / CBD@Met, a preparation method therefor and application thereof. The nanoparticles TK-PSBs / CBD@Met are nanoparticles formed by wrapping cannabidiol and metformin with thione-modified lung surfactant biomimetic liposomes. In vitro experiments have confirmed that the nanoparticles TK-PSBs / CBD@Met can effectively inhibit the fibrosis process of BEAS-2B cells induced by silicon dioxide. Animal experiments have shown that the nanoparticles TK-PSBs / CBD@Met can significantly improve the damage to the lung tissue structure and abnormal deposition of collagen caused by SiO2 exposure, and alleviate the pathological progression of silicosis fibrosis.

The invention belongs to the technical field of medicines, and particularly relates to a probiotic-fermented medicinal and edible traditional Chinese medicine composition as well as a preparation method and application thereof. Specifically, the medicinal and edible traditional Chinese medicine composition comprises the following components: Chinese yam, lotus seed, white hyacinth bean, fingered citron, dandelion, coix seed, Chinese date, malt and liquorice. According to the invention, the medicinal and edible traditional Chinese medicine raw materials are crushed, and the probiotics are added for fermentation treatment, so that the medicinal and edible traditional Chinese medicine composition based on probiotic fermentation is obtained, and the composition has a good curative effect on chronic diseases such as gastrointestinal diseases and the like, thereby having a good practical application value.