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221results about How to "low toxicity" patented technology

Oligonucleotide decoys and methods of use

ActiveUS20090099108A1efficiently transferlow toxicity
The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN's in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable. In one embodiment, this includes use as a research tool, including studies of specific genes and studies to identify specific genes regulated by the transcription factors targeted. In another embodiment, the present invention provides for using polyamides for NF-kB-specific CODN delivery in the treatment of myocardial ischemia/reperfusion and myocardial infarction, heart failure and hypertrophy, cardioprotection, stroke, neuroprotection, sepsis, arthritis, asthma, heritable inflammatory disorders, cancer, heritable immune dysfunctions, inflammatory processes, whether caused by disease or injury or infection, oxidative stress to any organ whether caused by disease, surgery or injury. The decoys may be any transcription factors, including, but not limited to, NF-kB, AP-I, ATF2, ATF3, SP 1 and others.
Owner:UNIVERSITY OF CINCINNATI

ph and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as preparation method and application thereof

The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.
Owner:天津渤化讯创科技有限公司

Traditional Chinese medicament containing far-infrared-anion nano silver, zinc and selenium elements for externally treating burns and scalds

InactiveCN101757246Alow toxicityStrong antibacterial ability
The invention provides a traditional Chinese medicament containing far-infrared-anion nano silver, zinc and selenium elements for externally treating burns and scalds, belonging to the production technical field of preparation of the medicament for externally treating burns and scalds by a high-tech nanometer technology. Burns and scalds are injuries on a body surface tissue caused by a heat source, and large-area deep burns and scalds can be complicated by shock, septicemia and the like; and the content of zinc, copper, ferrum and selenium is low and the content of nickel and aluminum is high in human body, so burn shock and lead poisoning easily occur. In the traditional Chinese medicament, rhizoma coptidis, phellodendron bark and radix scutellariae can clear away heat and toxic materials and realize antibiosis and anti-inflammation; rhubarb can improve local disturbance of blood circulation; and tree peony bark, red peony root and dried rehmannia root can clear away heat, cool blood and activate blood circulation and reduce exudates on a wound surface. In general, the traditional Chinese medicament can be mainly used for clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis, resisting exudation, promoting growth of epithelial cells, accelerating wound healing and realizing no black spots after healing; and a broad-spectrum high-effective nano silver system '(AT) antimicrobial' is added to the traditional Chinese medicament, thus the nanometer technology greatly improves the curative effect of the medicament and provides the latest scientific research direction for quick recovery of burns and scalds.
Owner:成钢

Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure

The invention discloses a preparation method of a magnetic fluorescent dual-function nano particle with nuclear shell structure, comprising the following steps: (1) magnetic nano particles are prepped by a conventional method, and then the magnetic nano compound particles with amination surfaces are obtained by adopting the conventional method; bromo-alkyl acylbromide is adopted to react with the amino on the surface of the amino, so as to obtain the initiator-modified magnetic nano particles; (2) the initiator obtained in the step (1), fluorescent monomers, catalyst, ligand and reducing agents form a polymerization system, and the polymerization system is dissolved in solvent, the shell formed by fluorescence polymers is obtained by carrying out electronic activation regeneration atom transfer radical polymerization, so as to obtain the magnetic fluorescent dual-function nano particle with nuclear shell structure; as the invention adopts the fluorescent monomers to carry out active radical polymerization directly, and the obtained grafting fluorescent polymer shell is linked on the surface of the magnetic nano particles in a covalent way, so as to be beneficial to maintaining stable performance of the magnetic fluorescent dual-function nano particle with nuclear shell structure in the practical using process.
Owner:SUZHOU UNIV
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