1558results about "Implantable neurostimulators" patented technology

Various aspects of this disclosure relate to a prosthetic cover comprising an array of sensors, which transmit signals to an array of electrodes in a liner that fits over a residual limb of an amputee. Different interactions with the prosthetic cover cause different activation of the electrodes to transmit electrical current through different areas of the residual limb and modulate neurons differently within the residual limb. Various aspects of this disclosure also relate to a prosthetic liner with a substrate that includes electrodes for transcutaneous electrical nerve stimulation and / or electronic muscle stimulation for a residual limb.

The invention discloses a peripheral nerve stimulation system based on muscle fatigue prediction and compensation, which is used for acquiring electromyographic signals and predicting muscle fatigue states during nerve stimulation, and timely warning and adjusting stimulation to ensure the stability of muscle strength, and comprises a stimulation output module used for stimulating target nerves to activate target muscles according to stimulation parameters; the acquisition and analysis module is used for synchronously acquiring electromyographic signals of target muscles, preprocessing the electromyographic signals and extracting electromyographic signal features; the fatigue prediction module is used for predicting the fatigue state of the muscle according to the electromyographic signal characteristics; the compensation control module is used for adjusting stimulation parameters according to the fatigue state of the muscle and sending the stimulation parameters to the stimulation output module to ensure that the muscle strength is stable in the stimulation process; and the user interaction module is used for performing stimulation control and setting in real time and displaying the stimulation effect and the muscle fatigue state. Muscle fatigue and strength attenuation in the peripheral nerve stimulation process can be dynamically predicted and compensated in time, and the safety, accuracy and reliability of nerve stimulation are improved.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

The invention relates to the technical field of medical instruments, in particular to a nerve stimulation electrode based on a shape memory material. The nerve stimulation electrode comprises a flexible packaging electrode body and a substrate crease layer arranged on the surface of the flexible packaging electrode body. The material of the substrate crease layer comprises a shape memory polymer and a nano ferromagnetic material; the substrate crease layer comprises a first bending part which is used for enabling the flexible packaging electrode body to be folded along the length direction of the flexible packaging electrode body. The nerve stimulation electrode can solve the problems that an existing nerve stimulation electrode is hard in appearance, large in overall mass, poor in flexibility and complex in implantation operation.

An interventional device for a tubular body, comprising: a stent switchable between a first state and a second state, the diameter of the stent in the second state being greater than the diameter of the stent in the first state; the at least one puncture part is arranged on the stent, and the puncture part is used for puncturing the wall of the tubular body when the stent is in the second state; the at least one electrode is arranged on the at least one puncture part, and the electrode is used for extending out of the tubular body from the area, punctured by the puncture part, of the wall. By means of the scheme, effective implantation of the electrode can be achieved based on the intervention device, the implanted electrode can make direct contact with the biological tissue target area outside the tubular body, direct and non-barrier signal interaction is achieved, and the signal collecting and stimulation applying effects of the electrode are greatly improved.

Embodiments of the present disclosure may include a neuromodulation system. The neuromodulation system can include an implantable pulse generator configured to provide neuromodulation to a patient based on a sequence of neuromodulation programs. The implantable pulse generator can include alternately accessible memories. The alternately accessible memories can enable the implantable pulse generator to store a second neuromodulation program while providing neuromodulation according to a first neuromodulation program. The IPG can then transition from providing stimulation according to the first neuromodulation program to providing stimulation according to the second neuromodulation program without stopping stimulation. The neuromodulation system can include a parameter memory. Stimulation parameter updates can be written to the parameter memory. The value of the parameter memory can be used to determine the next stimulation pulse. The IPG can accordingly support pulse-to-pulse changes in stimulation parameters.

Various aspects of this disclosure relate to a layered polymer substrate with electrodes and conductive ink embedded in the substrate. In some embodiments, a prosthetic liner may be bonded onto the polymer substrate. The substrate may include an interconnect coupled to the electrodes via the conductive ink. The system may include a controller (e.g., an electrode controller) in communication with the electrodes via the conductive ink. The electrodes may be activated such that they may stimulate nerve fibers in a user's residual limb.

The present disclosure provides an implanted nerve stimulator electrode for an implanted nerve stimulation system, the implanted nerve stimulator electrode being adapted to be at least partially implanted into a human body and receiving an electrical signal from an implanted pulse generator to apply electrical stimulation to the human body. An implanted nerve stimulator electrode includes an elongate body, a plurality of wires, and at least one nerve stimulation contact structure. The nerve stimulation contact structure is in a hollow sleeve shape and is suitable for being arranged on the main body in a sleeving mode. Each nerve stimulation contact structure comprises at least two contacts, and when the nerve stimulation contact structures are arranged on the main body in a sleeving mode, each contact on the nerve stimulation contact structure is electrically connected with one corresponding wire. After the nerve stimulation contact structure provided by the invention is sleeved on the main body, an operator can weld the corresponding wire to the contact under the condition of no shielding or little shielding, so that the welding difficulty from the contact to the wire is reduced. And the production efficiency is improved.

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

Disclosed herein are systems, devices, and methods for implanting electrodes within a cerebral vessel of a subject. For example, disclosed are various types of implantable electrode arrays, stents carrying electrode arrays, delivery devices for implantable electrode arrays, electrical interfaces for an implantable electrode array, connector lead cable assemblies for an implantable electrode array, and methods of delivering and deploying implantable electrode arrays.

A medical apparatus for a patient comprises an external system configured to transmit one or more transmission signals, each transmission signal comprising at least power or data; and an implantable system configured to receive the one or more transmission signals from the external system. The apparatus can be configured to treat a patient and / or record patient data. Methods of treating a patient and recording patient data are also provided.

The invention relates to the technical field of neural engineering and brain-computer interfaces, in particular to a closed-loop multi-modal nerve stimulation system and method based on time interference, and the system comprises a multi-modal stimulation module which is used for integrating electrical stimulation, magnetic stimulation and optical genetic stimulation, and generating a time interference field domain; the neural state sensing module is used for collecting real-time electroencephalogram signals, blood oxygen concentration and neural metabolite level data; the neural control center is used for fusing neural state data and stimulation parameters, and dynamically adjusting time interference frequency and stimulation intensity through an adaptive algorithm; the time sequence cooperation engine predicts a neural response time phase based on a deep learning model, and optimizes a stimulation time sequence and a mode switching strategy; and the visual interaction platform is used for rendering the nerve activation thermodynamic diagram and the stimulation parameter adjustment curve in real time. Therefore, the problems of adjustment strategy solidification, low adjustment precision, insufficient energy conversion efficiency and the like in the prior art are solved.

Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and / or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

The invention provides a primitive-based brain-like visual prosthesis system, a partitioned electrical stimulation method and a partitioned electrical stimulation device, and relates to the technical field of visual prostheses. A primitive-based brain-like visual sensor acquires a space-time difference image and a color intensity image, performs primitive extraction to obtain multiple pieces of primitive information in a multi-bit form; encoding by adopting different encoding modes through a pulse encoder to obtain a plurality of pieces of primitive information in a single-bit form; and the processor controls the implantable electrode arrays in different areas to generate electrical stimulation signals based on the primitive information in a multi-bit form or a single-bit form, generates regulation and control signals based on the fed-back electroencephalogram signals, and adjusts attribute parameters of the brain-like vision sensor based on the regulation and control signals. Based on the characteristics of low bandwidth, high robustness and pulse coding of the brain-like vision sensor, the brain-like vision prosthesis system can efficiently perceive the external environment and perform partitioned electrical stimulation based on primitive processing, so that the visual experience of a user is improved.

A cuff lead arrangement includes a first cuff lead having a first cuff body; first stimulation emitters (for example, electrodes) disposed on an interior surface of the first cuff body; a first lead body coupled to the first cuff body; first conductors electrically coupled to the first stimulation emitters and extending along the first lead body; and at least one first connection element. The cuff lead arrangement further includes a second cuff lead having a second cuff body; second stimulation emitters disposed on an interior surface of the second cuff body; a second lead body coupled to the second cuff body; second conductors electrically coupled to the second stimulation emitters and extending along the second lead body; and at least one second female connection element configured to receive the at least one first male connection element to conjoin the first cuff lead to the second cuff lead.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

An example of a system for delivering neurostimulation may include a programming control circuit and a user interface. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a pulse sequence. The pulse sequence may include a series of neurostimulation pulses and be defined by sequence parameters and one or more modulation functions each modulating an adjustable parameter selected from the sequence parameters. The user interface may be configured to set the pulse sequence to a tonic pulse sequence by determining an initial value for each adjustable parameter and set the pulse sequence to a modulated pulse sequence by selecting one or more adjustable parameters, determining a modulation function for each selected adjustable parameter, and applying the determined modulation function to that selected adjustable parameter to modulate the tonic pulse sequence.

An embodiment of a mind-view communication apparatus includes a first portable unit and a second portable unit. The first portable unit includes an eyeglass frame, at least one first optical unit disposed on the eyeglass frame for capturing at least one scene image corresponding to a field of view of a user, and at least one second optical unit disposed on the eyeglass frame for capturing at least one eye image corresponding to at least a portion of at least one eye of the user. The second portable unit is in communication with the first portable unit and includes at least one processor configured for receiving the at least one scene image and the at least one eye image, determining a direction within the field of view to which the at least one eye is directed based upon the at least one eye image, and generating a subset of the at least one scene image based on the determined direction.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP -based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises determining identification data and identifying implantable medical device (IMD) information, initiating an imaging device and determining an imaging program, receiving one or more frames of image data including image(s) of an implantation site, identifying an abnormality at the implantation site, triggering a supplemental image capture mode, receiving one or more supplemental images of the implantation site, and outputting the one or more supplemental images of the implantation site.

Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises identifying a first set of images that represent a particular location of a body of a patient in which at least one component of an implantable medical device (IMD) coincides, determining a projection of alteration characteristics of the particular location of the body, identifying a second set of images, determining a second set of alteration characteristics, comparing the second set of alteration characteristics to the projection, and identifying a potential abnormality at the particular location of the body.

A neurostimulation system that has a programmer which has a power supply and processors with processing circuitry and a neurostimulation device which has power supply, processors and communication circuitry for providing communication with a neurostimulation device as well as communication circuitry for communication with the programmer. The neurostimulation system is configured to deliver treatment to a patient in accordance with a clinician prescribed protocol of a regimen. The neurostimulation system compares a delivered therapy treatment which has a treatment protocol to a defined treatment protocol of a prescribed treatment and adjusts the prescribed treatment stimulation parameters to compensate for a difference between the delivered neurostimulation therapy treatment and the prescribed treatment protocol for closely approximating the prescribed treatment protocol.

Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP-based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

A system for automated programming of stimulation devices uses machine learning with multimodal medical imaging data to determine optimal patient-specific parameters. The system stores voxel-level intensity and functional imaging data from patients who previously underwent stimulation therapy. Similarity metrics calculated directly between the raw imaging data are used to cluster patients into phenotypic groups. Known therapeutic outcomes for each patient are linked to the associated stimulation parameters. For a new patient, biomarkers are extracted from their medical imaging data and used to identify phenotypically similar groups. The stimulation parameters with beneficial outcomes in those groups are analyzed to determine target recommended settings or discard suboptimal settings for the new patient. This data-driven approach leverages machine learning on multimodal medical imaging to automate patient-specific programming of stimulation therapy devices for optimal therapeutic benefit without requiring spatial normalization or atlas registration.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

A system may include a plurality of electrodes and a neural modulation device configured to deliver energy using at least some of the plurality of electrodes to modulate the volume of neural tissue. The neural modulation device may be configured to deliver the energy according to a modulation parameter set. The system may include a programming system configured to program the neural modulation device with the modulation parameter set for use to deliver the energy. The energy corresponds to a broad-spectrum signal having a plurality of frequency ranges, and the programming system is configured to receive user input for targeting energy to a volume of tissue, determine a stimulation configuration, including the modulation parameter set, based on the user input, and deliver the energy corresponding to the broad-spectrum signal using the plurality of electrodes according to the determined stimulation configuration.

The invention discloses a stimulating electric field display method, device, system and equipment, a medium and a product. The method comprises the steps that in response to a model display operation, a target object and a brain tissue image model corresponding to the target object are determined, and the brain tissue image model comprises at least one deep brain stimulation electrode model; in response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each electrode model; and in response to an electric field display operation, determining program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displaying the program-controlled electric field information on the displayed brain tissue image model. Based on the technical scheme of the invention, the effect of quickly calculating and displaying the distribution condition of the program-controlled electric field simulated by any electrode configuration and the electrode model under the applied voltage on the brain tissue image model can be realized, and a technician can be effectively assisted in performing deep brain stimulation electrode configuration.

The invention provides implantable electrical stimulation equipment and a control method, device and system thereof, the equipment comprises a controller, an impedance detection device, a stimulation circuit, a switching circuit and an acquisition circuit, and the controller is configured to obtain a characteristic value of a waveform of an ECAP signal of a body of a patient in a current posture; measuring a first impedance value of a body, between the first electrode contact and the second electrode contact, of the patient through an impedance detection device, and determining contact conditions of the first electrode contact and the second electrode contact with the body of the patient based on the first impedance value; and determining whether to switch different electrode contacts to transmit pulses according to the contact condition and the characteristic value. When the electrode contacts are twisted and are in poor contact with the body of a patient, a proper electrode contact is switched in time to output a treatment pulse, so that the treatment part is accurately stimulated, and the accuracy and the treatment effect of the treatment process are ensured.