1002results about "Implantable neurostimulators" patented technology

Various aspects of this disclosure relate to a layered polymer substrate with electrodes and conductive ink embedded in the substrate. In some embodiments, a prosthetic liner may be bonded onto the polymer substrate. The substrate may include an interconnect coupled to the electrodes via the conductive ink. The system may include a controller (e.g., an electrode controller) in communication with the electrodes via the conductive ink. The electrodes may be activated such that they may stimulate nerve fibers in a user's residual limb.

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

A medical apparatus for a patient comprises an external system configured to transmit one or more transmission signals, each transmission signal comprising at least power or data; and an implantable system configured to receive the one or more transmission signals from the external system. The apparatus can be configured to treat a patient and / or record patient data. Methods of treating a patient and recording patient data are also provided.

The invention relates to the technical field of neural engineering and brain-computer interfaces, in particular to a closed-loop multi-modal nerve stimulation system and method based on time interference, and the system comprises a multi-modal stimulation module which is used for integrating electrical stimulation, magnetic stimulation and optical genetic stimulation, and generating a time interference field domain; the neural state sensing module is used for collecting real-time electroencephalogram signals, blood oxygen concentration and neural metabolite level data; the neural control center is used for fusing neural state data and stimulation parameters, and dynamically adjusting time interference frequency and stimulation intensity through an adaptive algorithm; the time sequence cooperation engine predicts a neural response time phase based on a deep learning model, and optimizes a stimulation time sequence and a mode switching strategy; and the visual interaction platform is used for rendering the nerve activation thermodynamic diagram and the stimulation parameter adjustment curve in real time. Therefore, the problems of adjustment strategy solidification, low adjustment precision, insufficient energy conversion efficiency and the like in the prior art are solved.

Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and / or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

The invention provides a primitive-based brain-like visual prosthesis system, a partitioned electrical stimulation method and a partitioned electrical stimulation device, and relates to the technical field of visual prostheses. A primitive-based brain-like visual sensor acquires a space-time difference image and a color intensity image, performs primitive extraction to obtain multiple pieces of primitive information in a multi-bit form; encoding by adopting different encoding modes through a pulse encoder to obtain a plurality of pieces of primitive information in a single-bit form; and the processor controls the implantable electrode arrays in different areas to generate electrical stimulation signals based on the primitive information in a multi-bit form or a single-bit form, generates regulation and control signals based on the fed-back electroencephalogram signals, and adjusts attribute parameters of the brain-like vision sensor based on the regulation and control signals. Based on the characteristics of low bandwidth, high robustness and pulse coding of the brain-like vision sensor, the brain-like vision prosthesis system can efficiently perceive the external environment and perform partitioned electrical stimulation based on primitive processing, so that the visual experience of a user is improved.

A cuff lead arrangement includes a first cuff lead having a first cuff body; first stimulation emitters (for example, electrodes) disposed on an interior surface of the first cuff body; a first lead body coupled to the first cuff body; first conductors electrically coupled to the first stimulation emitters and extending along the first lead body; and at least one first connection element. The cuff lead arrangement further includes a second cuff lead having a second cuff body; second stimulation emitters disposed on an interior surface of the second cuff body; a second lead body coupled to the second cuff body; second conductors electrically coupled to the second stimulation emitters and extending along the second lead body; and at least one second female connection element configured to receive the at least one first male connection element to conjoin the first cuff lead to the second cuff lead.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

An example of a system for delivering neurostimulation may include a programming control circuit and a user interface. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a pulse sequence. The pulse sequence may include a series of neurostimulation pulses and be defined by sequence parameters and one or more modulation functions each modulating an adjustable parameter selected from the sequence parameters. The user interface may be configured to set the pulse sequence to a tonic pulse sequence by determining an initial value for each adjustable parameter and set the pulse sequence to a modulated pulse sequence by selecting one or more adjustable parameters, determining a modulation function for each selected adjustable parameter, and applying the determined modulation function to that selected adjustable parameter to modulate the tonic pulse sequence.

An embodiment of a mind-view communication apparatus includes a first portable unit and a second portable unit. The first portable unit includes an eyeglass frame, at least one first optical unit disposed on the eyeglass frame for capturing at least one scene image corresponding to a field of view of a user, and at least one second optical unit disposed on the eyeglass frame for capturing at least one eye image corresponding to at least a portion of at least one eye of the user. The second portable unit is in communication with the first portable unit and includes at least one processor configured for receiving the at least one scene image and the at least one eye image, determining a direction within the field of view to which the at least one eye is directed based upon the at least one eye image, and generating a subset of the at least one scene image based on the determined direction.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP -based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises determining identification data and identifying implantable medical device (IMD) information, initiating an imaging device and determining an imaging program, receiving one or more frames of image data including image(s) of an implantation site, identifying an abnormality at the implantation site, triggering a supplemental image capture mode, receiving one or more supplemental images of the implantation site, and outputting the one or more supplemental images of the implantation site.

Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises identifying a first set of images that represent a particular location of a body of a patient in which at least one component of an implantable medical device (IMD) coincides, determining a projection of alteration characteristics of the particular location of the body, identifying a second set of images, determining a second set of alteration characteristics, comparing the second set of alteration characteristics to the projection, and identifying a potential abnormality at the particular location of the body.

A neurostimulation system that has a programmer which has a power supply and processors with processing circuitry and a neurostimulation device which has power supply, processors and communication circuitry for providing communication with a neurostimulation device as well as communication circuitry for communication with the programmer. The neurostimulation system is configured to deliver treatment to a patient in accordance with a clinician prescribed protocol of a regimen. The neurostimulation system compares a delivered therapy treatment which has a treatment protocol to a defined treatment protocol of a prescribed treatment and adjusts the prescribed treatment stimulation parameters to compensate for a difference between the delivered neurostimulation therapy treatment and the prescribed treatment protocol for closely approximating the prescribed treatment protocol.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP-based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.

A system for automated programming of stimulation devices uses machine learning with multimodal medical imaging data to determine optimal patient-specific parameters. The system stores voxel-level intensity and functional imaging data from patients who previously underwent stimulation therapy. Similarity metrics calculated directly between the raw imaging data are used to cluster patients into phenotypic groups. Known therapeutic outcomes for each patient are linked to the associated stimulation parameters. For a new patient, biomarkers are extracted from their medical imaging data and used to identify phenotypically similar groups. The stimulation parameters with beneficial outcomes in those groups are analyzed to determine target recommended settings or discard suboptimal settings for the new patient. This data-driven approach leverages machine learning on multimodal medical imaging to automate patient-specific programming of stimulation therapy devices for optimal therapeutic benefit without requiring spatial normalization or atlas registration.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The invention discloses a stimulating electric field display method, device, system and equipment, a medium and a product. The method comprises the steps that in response to a model display operation, a target object and a brain tissue image model corresponding to the target object are determined, and the brain tissue image model comprises at least one deep brain stimulation electrode model; in response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each electrode model; and in response to an electric field display operation, determining program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displaying the program-controlled electric field information on the displayed brain tissue image model. Based on the technical scheme of the invention, the effect of quickly calculating and displaying the distribution condition of the program-controlled electric field simulated by any electrode configuration and the electrode model under the applied voltage on the brain tissue image model can be realized, and a technician can be effectively assisted in performing deep brain stimulation electrode configuration.

An auditory neural interface device for sound perception by an individual that may be used as a hearing aid. The auditory neural interface device includes a receiver configured to receive sound signals, a processor operably connected to the receiver and configured to encode a received sound signal as a multi-channel neurostimulation signal, and a neurostimulation device operably connected to the processor and configured to apply the multi-channel neurostimulation signal to a neurostimulation electrode of the individual. The neurostimulation signal is configured to directly stimulate afferent sensory neurons of the central nervous system of the individual and thereby to elicit, for each channel of the neurostimulation signal, one or more non-auditory, preferably somatosensory, perceptions in a cortex area of the individual. Each channel of the neurostimulation signal is associated with a different non-auditory perception.

Rechargeable lithium-ion cells and implantable medical devices including the same are provided herein with niobium-based negative electrodes and high voltage positive electrodes. Electrode active materials are provided herein, including pseudoternary compositions within a Ti-Nb-W-O pseudoternary system and / or including titanium, niobium, oxygen, and an elemental dopant. Rechargeable lithium-ion cells provide herein with niobium-based negative electrodes afford improved energy density, and, more particularly, provide improved energy density at operating voltages for use in implantable medical devices.

Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and / or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

Disclosed are an implantable electrode, a stimulator and a control method therefor, an electronic device, and a storage medium. The implantable electrode comprises: a control module, the control module being configured to receive a gating instruction from a pulse generator and generate a switch control signal; an array switch, the array switch being configured to establish multiple gating channels according to the switch control signal; an electrode array module, the electrode array module comprising multiple contacts, each contact being configured to deliver electrical stimulation to a tissue in a patient via the gating channels established by the array switch, or collect physiological signals from a tissue in a patient. The switch control signal is used to isolate the stimulation contacts from the collection contacts.

Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and / or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and / or activate or increase circulation of one or more immune cells (such as natural killer cells and / or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.

The invention belongs to the technical field of medical apparatus and instruments, and particularly provides an eye-brain organ complex visual restoration system based on cooperative training, comprising: an eye-brain organ complex construction module for constructing a functional eye-brain organ complex; the signal processing module is used for collecting and processing an initial nerve spike signal generated by the brain organ; the stimulation signal generation module is used for generating an electrical stimulation signal for simulating the response of the photoreceptor through an adaptive modulation algorithm; the signal decoding and mapping module is used for stimulating a brain organ to generate a new nerve spike signal based on the electrical stimulation signal and decoding the new nerve spike signal into an external equipment control instruction; and the closed-loop feedback control module is used for performing closed-loop feedback control and optimization on the eye and brain organ complex visual restoration system based on cooperative training. According to the invention, the visual information in the biological signal can be correctly identified and utilized.

Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and / or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and / or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

An embodiment of a mind-view communication apparatus includes a first portable unit and a second portable unit. The first portable unit includes an eyeglass frame, at least one first optical unit disposed on the eyeglass frame for capturing at least one scene image corresponding to a field of view of a user, and at least one second optical unit disposed on the eyeglass frame for capturing at least one eye image corresponding to at least a portion of at least one eye of the user. The second portable unit is in communication with the first portable unit and includes at least one processor configured for receiving the at least one scene image and the at least one eye image, determining a direction within the field of view to which the at least one eye is directed based upon the at least one eye image, and generating a subset of the at least one scene image based on the determined direction.

The invention discloses a real-time collaborative cross-scene visual assistance and environment perception system for visually impaired people based on head-mounted equipment. According to the invention, through fusion of a multi-mode perception technology and a neural feedback mechanism, all-around environmental cognition support is provided for visually impaired people. Key targets such as curbs, steps and traffic signals in a complex scene can be accurately recognized, and a safe navigation scheme is generated in real time in combination with a dynamic path planning and obstacle avoidance algorithm. Through personalized feedback modes such as voice and vibration, the system can adjust the interaction rhythm according to the behavior habit and cognitive state of the user, ensure efficient and natural information transmission, effectively reduce the cognitive load of the user, help the visually impaired people to travel autonomously in different environments, improve the independent living ability, and improve the user experience. Real-time response and calculation efficiency are balanced through a collaborative architecture, so that a high-performance auxiliary function is not limited by heavy hardware equipment any more. The universal design reduces the use threshold, and is helpful for more visually impaired people to enjoy the convenience brought by science and technology.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A method of identifying a patient with obstructive sleep apnea implants a phrenic nerve stimulator in the patient or connects the phrenic nerve stimulator to the diaphragm, and adjusts the stimulation energy applied by the phrenic nerve stimulator to the phrenic nerve of the sleeping patient based on airway occlusion in the airway of the patient.

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.