307results about "Implantable neurostimulators" patented technology

The invention discloses a real-time collaborative cross-scene visual assistance and environment perception system for visually impaired people based on head-mounted equipment. According to the invention, through fusion of a multi-mode perception technology and a neural feedback mechanism, all-around environmental cognition support is provided for visually impaired people. Key targets such as curbs, steps and traffic signals in a complex scene can be accurately recognized, and a safe navigation scheme is generated in real time in combination with a dynamic path planning and obstacle avoidance algorithm. Through personalized feedback modes such as voice and vibration, the system can adjust the interaction rhythm according to the behavior habit and cognitive state of the user, ensure efficient and natural information transmission, effectively reduce the cognitive load of the user, help the visually impaired people to travel autonomously in different environments, improve the independent living ability, and improve the user experience. Real-time response and calculation efficiency are balanced through a collaborative architecture, so that a high-performance auxiliary function is not limited by heavy hardware equipment any more. The universal design reduces the use threshold, and is helpful for more visually impaired people to enjoy the convenience brought by science and technology.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

The invention relates to an in-vitro program controller and a control method thereof. The in-vitro program controller comprises a sensor and a processor, and the processor sets the working power of the implantable nerve stimulator, a temperature early warning value and a temperature upper limit value greater than the temperature early warning value according to the stimulation parameters; when the movement of the in-vitro program control instrument is determined at every reference time interval or according to the posture change detected by the sensor, a data reading instruction is sent to the implantable nerve stimulator so as to read the working power and temperature of the implantable nerve stimulator; increasing, decreasing or maintaining the transmitting power according to the comparison between the read working power and the set working power; according to the fact that the read temperature is larger than or equal to the set temperature early warning value and smaller than the set temperature upper limit value, the transmitting power is reduced; and sending a stimulation stop instruction when the read temperature is greater than or equal to a set temperature upper limit value. According to the invention, the working power, temperature and the like of the implantable nerve stimulator can be monitored and adjusted, so that safe treatment of a patient is ensured.

The invention discloses a neural tissue stimulator, characterized in that the neural tissue stimulator comprises a multiple of microneedles and a chip comprising at least one comparator with adaptive level, sequence control circuit, at least one capacitor stack built by n capacitors and 2n switches, at least one buffer capacitor outside the at least one capacitor stack, at least two additional switches outside the at least one capacitor stack, a CMOS-Logic, wherein further, the neural tissue stimulator comprises an interposer layer comprising holes for the multiple of microneedles and a lid. The neural tissue stimulator is characterized in, that the chip is located on one surface of the interposer layer and that the lid and the interposer layer form a capsule for the chip. Further, the neural tissue stimulator is adapted to be electrically self-sufficient.

Methods of treating a subject for a dissociative disorder and methods of screening agents for the ability to modulate dissociative and associative states in a subject are provided. In particular, agents that alter rhythmic neural activity in the posteromedial cortex can be used to modulate dissociative and associative states in a subject.

The present application relates to an apparatus (100) for stimulating a peripheral nerve. The apparatus comprises: an implantable electrode assembly (102), which can be implanted in the body of a patient, and is configured to apply a stimulation signal to a nerve. The implantable electrode assembly (102) comprises: a stimulation electrode (102a), which is fixed to a predetermined position of the body of the patient and is adjacent to a nerve therein, and is configured to operably apply a stimulation signal to the nerve; and an electrode circuit (102b), which is coupled to the stimulation electrode (102a), and is configured to receive stimulation energy in the form of an electromagnetic field, convert the stimulation energy into the stimulation signal and provide the stimulation signal to the stimulation electrode (102a), wherein the stimulation energy is from the outside of the implantable electrode assembly (102). The apparatus further comprises: a stimulation energy generator (104), which can be worn outside the body of the patient, so as to provide stimulation energy to the implantable electrode assembly (102) by means of electromagnetic field coupling. The stimulation energy generator (104) comprises: a generator circuit (658), which is used for generating stimulation energy in the form of an electromagnetic field; and a power source (660), which is coupled to the generator circuit (658), and is configured to supply power to the generator circuit (658).

A lead electrically connected to a stimulator and a stimulation system. The lead electrically connected to the stimulator comprises an insulating body (1) and a connecting section (13) at least partially inserted into the stimulator (3). The connecting section (13) comprises a conductive ring (11) mounted on the insulating body (1) and at least one sealing part (2), and the sealing part (2) abuts against a sealing member (31) in the stimulator (3), such that the connecting section inserted into the stimulator (3) is sealed. The lead electrically connected to the stimulator further comprises an air-venting structure provided on the connecting section (13), and the air-venting structure is configured to reduce the insertion and extraction force when the connecting section (13) is inserted into the stimulator (3).

This document discusses neurostimulation devices, systems, and methods. A neurostimulation system receives a physiological target region for the neurostimulation and one or more optimization criteria for the neurostimulation of the target region. The neurostimulation system determines a likelihood of finding a stimulation configuration solution using a first optimization algorithm according to the physiological target region, determines a likelihood that the stimulation configuration solution is a better solution than what would be found by a second optimization algorithm and selects the first optimization algorithm or the second optimization algorithm according to the determined likelihood. The neurostimulation system recurrently changes stimulation parameters according to the selected optimization algorithm to determine the stimulation configuration solution based on the one or more optimization criteria and presenting the stimulation configuration solution to a user. The neurostimulation system comprises: a stimulation control circuit to deliver the neurostimulation according to a specified stimulation configuration, the stimulation configuration including multiple stimulation parameters; a port to receive a designation of a target region for the neurostimulation; a user interface configured to receive one or more optimization criteria for the neurostimulation of the target region; and a programming control circuit configured to perform the optimisation.

Devices, systems and methods are described for providing muscle contraction stimulation therapy to treat myriad diseases, including heart failure, Type 2 diabetes, and peripheral vascular disease using a skin patch or implantable stimulator that includes a multiplicity of electrodes, a processor, a stimulation circuit, one or more sensors and programming for a patient interface unit, wherein the processor is programmed to control selection of a subset of the multiplicity of electrodes and of operation of the stimulation circuit responsive to an indication of an adverse physiologic response. The indication of patient discomfort may be determined by monitoring a physiologic parameter of the subject using the one or more sensors, by direct input from the subject via the patient interface unit programming, or a combination thereof. The devices, systems and methods also provide for automatically optimizing the stimulation parameters applied by the stimulation circuit responsive to feedback from the one or more sensors and / or by using direct input from the subject.

A nerve electrostimulation system using capacitive coupling energy transmission, in-vivo nerve electrostimulator, and in-vitro energy controller thereof. The nerve electrostimulation system using capacitive coupling energy transmission includes an in-vivo nerve electrostimulator and an in-vitro energy controller, and may also include a program controller having an upper computer control APP. The in-vivo nerve electrostimulator includes at least one stimulator coupling capacitor pole, a stimulator compensation resonant network, a rectification circuit, a filter capacitor, a main control chip, a stimulator harmonic communication module, and a plurality of sets of stimulation electrodes and corresponding balance capacitors, wherein the stimulator coupling capacitor pole is coupled with an energy controller coupling capacitor pole of the in-vitro energy controller, thereby receiving electrical energy from the in-vitro energy controller and achieving information exchange. The nerve electrostimulation system using capacitive coupling energy transmission can increase the electrical power to be transmitted.

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

The invention discloses an acquisition and stimulation in-situ integrated capacitive coupling type active neural electrode array and a preparation method thereof. The electrode array comprises a flexible substrate and a plurality of neural electrode units on the flexible substrate, the neural electrode unit comprises two silicon nano films, a gate dielectric layer, a metal layer and a capacitive coupling dielectric layer, wherein the two silicon nanometer films are located on the flexible substrate, the gate dielectric layer covers the silicon nanometer films, and the metal layer comprises electrode metal, a metal bonding pad and a metal interconnection line; the electrode metal is matched with the two silicon nanometer films, the gate dielectric layer and the flexible substrate to form a selection transistor and a driving transistor, and the metal bonding pad is matched with the capacitance coupling dielectric layer to form an electrode contact; metal interconnects electrically connect the select transistors, the drive transistors, and the electrode contacts. The selection transistor and the driving transistor form an acquisition and stimulation closed-loop control unit, so that synchronous electroneurographic signal acquisition and electrical stimulation are realized, the experiment and treatment efficiency is improved, and the loss and interference in the signal transmission process are reduced.

A method of implanting a nerve stimulation device in treating an overactive bladder condition includes providing an external programmer and providing an implantable tibial nerve stimulation device (ITNS device) including a pulse generator enclosing circuitry and a lead coupling an electrode assembly to the pulse generator. The external programmer wirelessly communicates with the circuitry of the pulse generator to program a stimulation therapy for the ITNS device.

An implantable neuro-modulator device, including a hermetically sealed housing, wherein an antenna for communicating with external devices and / or for wirelessly receiving electrical energy is positioned within the housing, wherein a major part of the housing is electromagnetically transparent to radiation in the frequency range below 20 MHz, in particular between 5 and 15 MHz.

A system for providing neurostimulation to a patient includes a pulse generator having a housing. The implantable neurostimulation lead is configured to connect with a pulse generator, and the pulse generator is configured to generate a plurality of electrical pulses for delivering neurostimulation therapy through the lead to a patient when the lead is implanted at a target location. The lead includes one or more conductors extending from a proximal end of the lead to one or more neurostimulation electrodes disposed at or near a distal end of the lead. The lead comprises an energy absorber comprising a carbon nanotube material and extending substantially along the length of the one or more conductors.

The invention discloses a wrapping material for implantable electronic equipment and a preparation method of the wrapping material. The wrapping material comprises a degradable polymer base material with a porous structure and a drug-loaded slow-release coating uniformly loaded on the degradable polymer base material, holes in the degradable polymer are uniformly distributed in a staggered array mode, the holes are circular, the hole diameter is 0.5-3.0 mm, and the distance between every two adjacent holes is 0.5-3.0 mm. According to the wrapping material disclosed by the invention, the degradable polymer is taken as a base material, and the drug-loading coating containing rifampicin and minocycline hydrochloride is loaded on the surface, so that slow release of antibiotic drugs can be realized, and the wrapping material has excellent antibacterial performance and complete absorbability in a biological environment; and the problems of biocompatibility, infection risk and secondary operation removal faced by the implantable electronic equipment for a long time are solved.

An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.

An implantable medical device (IMD) (102, 150) includes multiple stimulation engines (306-i) for independently stimulating respective electrode sets (312-i) of a lead system (106A / B, 186) while avoiding collisions and / or channel contention during stimulation delivery. A first voltage multiplier (302) is configured to generate an adjustable target voltage having sufficient headroom at an output node (304) that is commonly coupled to anodic nodes (308-i) of respective stimulation engines (306-i). Each stimulation engine (306-i) includes a secondary voltage multiplier (402) to drive the respective anode (308-i) and a current regulator (404) powered by a floating power supply (406), wherein the current regulator (404) is coupled to a cathodic node (306-i) and configured to control how much stimulation current is pulled from the patient tissue.

A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath.

A cuff lead can include securing rings disposed along the first and second edges of a cuff body and an elongate securing body for insertion through the interleaved securing rings to hold the securing rings of the first and second edge in an interleaved configuration. A cuff lead can include a slot portion disposed along a first edge of a cuff body, the slot portion defining an opening, and a tab disposed along a second edge of the cuff body for securing the cuff lead to a nerve. A cuff lead can include two cuff body pieces engaging each other to form a hinge for moving between an open position for receiving a nerve and closed position. A cuff lead can include a tunnel extending through a cuff body and an elongate body for insertion through the tunnel.

In one exemplary embodiment, a method and system for improving coagulation ability and / or triggering higher platelet activation rates in a subject via auricular nerve stimulation includes contacting the subject's skin with one or more treatment electrodes, each electrode positioned in a respective region of a nerve structure of the auriculotemporal nerve (ATN), a nerve structure connected to the ATN, a nerve structure of the auricular branch of the vagus nerve (ABVN), or a nerve structure connected to the ABVN, and applying one or more stimulation patterns to the electrodes.

The invention discloses a construction method of a high-stability interdigital supercapacitor, and the method comprises the steps: firstly designing the interdigital supercapacitor, and obtaining an interdigital conductive substrate through micromachining; then synthesizing a conductive organic frame nano material with good conductivity, and combining with a conductive polymer PEDOT: PSS to construct a composite flexible nano frame composite layer; by optimizing modification conditions, the composite material is modified on an interdigital conductive substrate, and a novel interdigital supercapacitor is prepared. The result shows that the constructed interdigital supercapacitor still keeps high specific capacitance and high stability after tens of thousands of charging and discharging cycles under different current densities. Based on the high-stability interdigital supercapacitor, a platform for promoting the neural stem cells to differentiate into neurons based on in-situ electrical stimulation is subsequently established in the method: electrical stimulation is continuously and stably applied through the interdigital supercapacitor, so that the differentiation speed of the neural stem cells is remarkably increased; and an effective research tool is provided for research of a basic molecular mechanism of neurodegenerative diseases.

An implantable neurostimulator that communicates with an extracorporeal energy controller through radio frequency and receives electrical energy, including: a main control chip that includes a main control CPU, a main memory, and a digital to analog conversion current source circuit; a stimulator antenna and its impedance matching circuit, which are radio-frequency coupled with the extracorporeal energy controller; a rectification energy storage circuit that extracts electrical energy from the received input signal and stores electrical energy; a modulation / demodulation circuit that extracts control information including clinical stimulation parameters from the received input signal; an electrode interface; one or more stimulation electrodes, with the electrode interface allocating stimulation pulse sequences to each corresponding stimulation electrode; wherein the main memory stores the received control information, the digital to analog conversion current source circuit generates the stimulation pulse sequences based on the clinical stimulation parameters, and the main control CPU controls operation of the implantable neurostimulator. The implantable neurostimulator of the present invention can avoid treatment failure caused by interruption or obstruction of radio frequency communication.

Systems and methods are described, which provides electrical stimulation to a person, while also facilitating EEG recording. The EEG recording can be analyzed to identify an intracerebral hemorrhage. In some examples, the EEG analysis can identify increased slow wave activity in a Delta frequency range of approximately 1-4Hz and / or reduced Alpha activity in the Alpha frequency range of approximately 8-13Hz. The systems and methods can include delivering electrical stimulation in response to the EEG analysis and / or notifying the person or a medical provider about the intracerebral hemorrhage.

A system includes memory, and processing circuitry coupled to the memory, the processing circuitry configured to: determine at least one of: a cross-electrical signal measurement at a first electrode on a first lead implanted within a tongue of the patient based on a stimulation signal between a second electrode on the first lead or a second lead implanted within the tongue of the patient and a third electrode, or a strain measurement of at least one of the first lead or the second lead. The processing circuitry is configured to determine movement of the tongue based on at least one of the cross-electrical signal measurement or the strain measurement, and generate information indicative of the movement of the tongue.

The present invention relates to a substantially planar neural electrode array, the electrode array comprising: a flexible base; a connector cable attached to the base; one or more flexible shafts protruding from the base, the shafts being arranged to protrude from the same surface of the base in the same plane so as to form a comb-like structure, each of the one or more shafts comprising one or more electrode contacts, the electrode contacts being electrically coupled to the connector cable; a first reinforcing layer extending over the base and a proximal portion of the one or more shafts, the proximal portion being adjacent to the base; and a second resorbable reinforcing layer extending over a distal portion of the one or more shafts, the distal portion being remote from the base, with an overlap between the first reinforcing layer and the second resorbable reinforcing layer. Furthermore, the present invention relates to a neural implant comprising one or more electrode arrays according to the present invention. Furthermore, the present invention relates to a method for manufacturing an electrode array according to the present invention.

Provided are a method for switching a stimulation scheme and a related product. The method comprises: in a sensing phase, determining, on the basis of an acquired bioelectric signal, a plurality of energy features of the bioelectric signal, wherein the energy features comprise an energy value or an energy proportion; comparing the plurality of energy features with one or more energy thresholds, wherein the one or more energy thresholds are used for defining a plurality of energy intervals; and determining, on the basis of energy intervals to which the plurality of energy features belong, whether to switch the stimulation scheme. The method can effectively avoid misjudgments caused by transient signal changes, so that the switching of the stimulation scheme is more accurate.

In one aspect, the present disclosure is directed to an implantable medical device including a housing having a generally planar portion, and a piezoelectric transducer disposed within the housing, wherein at least a portion of the piezoelectric transducer is arranged at an oblique angle to the generally planar portion of the housing, and an electrode to deliver a neurostimulation therapy. The implantable medical device is configured to receive energy signals from an external device and transduce the received energy signals into electrical power.

We offer pelvic floor muscle repair pants that provide a wider range of repair and a higher repair effect. [Solution] The pelvic floor muscle repair pants consist of a wearable pants body 1 and an electrical stimulation member 10 provided on the wearable pants body 1. The electrical stimulation member 10 is provided on the crotch area 11 of the wearable pants body 1 that corresponds to the wearer's perineum, and the electrical stimulation member 10 includes a first flexible electrode 211 and a second flexible electrode 212 that apply electrical stimulation to the pelvic floor muscles, corresponding to the front and rear sides of the wearer's pelvic floor muscles, respectively.