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669 results about "Drug administration" patented technology

The U.S. Food and Drug Administration (FDA) is the government agency responsible for reviewing, approving and regulating medical products, including pharmaceutical drugs and medical devices. It also regulates various other products, including food, cosmetics, veterinary drugs, radiation-emitting products, biological products and tobacco.

Individual mutation information-based intelligent decision-making system for precise targeted medication of tumors

The invention relates to the technical field of tumor treatment, in particular to an intelligent decision-making system for tumor precise targeted medication based on individual mutation information, which comprises a data processing layer, a variation annotation and function prediction layer, a knowledge base integration layer and a scheme decision-making engine and report visualization module. According to the intelligent decision-making system for tumor precise targeted medication based on individual mutation information, a rule engine and a prediction model are combined, dynamic priority ranking is output, multi-model fusion decision making is achieved, and clinical scene deep adaptation is achieved by predicting primary and secondary drug resistance, calculating liver and kidney function adjusting dosage and generating a combined medication time sequence scheme; through an individualized drug delivery scheme, combination drug use optimization is achieved, a visual clinical report is generated, clinical executable operation is further strengthened, and through algorithm quantification, a dynamic knowledge graph, AI auxiliary decision making and a clinical operation closed loop, the next-generation technical research direction of a tumor precise drug use system can be represented.
Owner:BEIJING BIOMASION TECH

Nursing pressure real-time monitoring system and method based on multi-modal data

The invention discloses a nursing pressure real-time monitoring system and method based on multi-modal data. The system comprises a data acquisition module, an intelligent analysis module, an analysis module and a real-time feedback module. The data acquisition module synchronously acquires physiological data, behavior activity data and environment situation data of nursing personnel and forms a nursing signal; the analysis module receives the nursing signal from the data acquisition module, receives the dynamic situation information from the intelligent analysis module, and generates a pressure state signal containing pressure event evaluation; the real-time feedback module receives the pressure state signal containing the pressure event evaluation from the analysis module, and generates and outputs a real-time feedback signal based on the pressure state signal. According to the nursing pressure real-time monitoring system and method based on the multi-modal data, the problem that traditional wearable equipment only collects physiological behavior data and cannot be associated with specific nursing situations such as drug administration operation and patient first aid can be solved.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Wearable device for patient monitoring and drug administration

A modular disease management system may provide medication management for a patient. The system may include a base configured to at least partially couple to a tissue site of a patient. The system may further include a medication bladder coupled to the base and configured to maintain medication. The system may further include a medication pump coupled to the medication bladder, comprising a conduit and muscle wire-actuated plungers, wherein the medication pump is configured to cause the medication to flow from the medication bladder through the conduit. The system may further include a cannula insertion device coupled to the medication pump via the conduit, wherein the cannula insertion device comprises a cannula, a spring, and a triggering component, wherein the cannula insertion device is configured to insert the cannula into the tissue site of the patient by actuation of the spring released by the triggering component.
Owner:WILLOW LAB INC

Anesthesia strategy generation system fusing time sequence data and knowledge graph

The invention discloses an anesthesia strategy generation system fusing time sequence data and a knowledge graph, and relates to the technical field of medical information processing. The method specifically comprises the steps that five types of vital sign data including arterial blood pressure, electrocardio and electroencephalogram are collected, correction is conducted in combination with traction marks and electrotome interference characteristics, and an analysis result is output; the inference analysis module executes double-track processing based on the analysis value, one track evaluates cortical suppression, shock and ventilation risks and generates a risk report, and the other track performs reverse arbitration when the blood oxygen data is abnormal; constructing a knowledge graph fusing the efficacy nonlinear cooperation equation, the age sensitive parameters and the drug administration sequence influence; and the strategy generation module integrates the multi-source data to generate a drug execution track, and executes fast and slow closed-loop regulation and control based on a risk report and an arbitration result. According to the invention, the adaptation capability of the system to individual differences, the abnormal signal identification and processing capability and the intelligent response level of the anesthesia strategy are improved, and the accuracy and safety of clinical anesthesia are significantly enhanced.
Owner:SHANGHAI YANGZHI REHABILITATION HOSPITAL

Clinical pharmacy intelligent management method and system and storage medium

The invention relates to the technical field of pharmacy management, in particular to a clinical pharmacy intelligent management method and system and a storage medium. The method comprises the following steps: acquiring total element data of a drug treatment chain in real time, wherein the total element data comprises a prescription instruction stream, a drug preparation parameter, a drug administration execution record and a patient physiological feedback signal; constructing a drug treatment chain dynamic evaluation engine; establishing a digital twinning mapping relationship between the administration operation and the clinical terminal for the total element data of the drug treatment chain by utilizing a drug treatment chain dynamic evaluation engine, and generating a drug digital relationship chain; and performing drug treatment chain breakage risk point identification on the drug digital relation chain based on a multi-dimensional deviation detection algorithm to obtain drug treatment abnormal risk points. Through real-time data acquisition, digital twinborn mapping and intelligent risk identification and intervention, intelligent management and accurate regulation and control of the drug treatment chain are improved, and intelligence and accuracy of drug treatment chain management are improved.
Owner:THE 971ST HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY NAVY

Step-by-step targeted placenta trophoblast micro-nano robot as well as preparation method and application thereof

PendingCN120037406AAntipyreticAnalgesicsCells/microLTrophoblast
The invention discloses a step-by-step targeting placenta trophoblast micro-nano robot as well as a preparation method and application thereof. The micro-nano robot comprises a yeast cell wall of a bag-shaped structure, bio-enzyme unevenly distributed on the surface of the yeast cell wall and targeted placenta trophoblast drug-loaded nanoparticles located in the yeast cell wall. The surfaces of the targeted placenta trophoblast drug-loaded nanoparticles are connected with placenta-like chondroitin sulfate A binding polypeptides. Inflammation placenta tissue can be targeted through macrophages, the medicine is accurately delivered to placenta trophoblastic cells through the medicine-carrying nano-particles connected with the targeting peptide, step-by-step accurate targeting is achieved, the medicine does not penetrate through the placenta barrier to reach the body of a fetus, and high biological safety is achieved for pregnancy administration.
Owner:THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY

Intelligent bandage integrating wound monitoring, drug administration and electrical stimulation

The invention discloses an intelligent bandage integrating wound monitoring, drug administration and electrical stimulation. The intelligent bandage comprises a bandage body, a portable battery, a wound monitoring module, an intelligent drug administration module, an electrical stimulation module and a portable control module. The bandage body is of a double-layer structure, the inner layer is an antibacterial fiber layer, and the outer layer is a breathable waterproof layer. By means of the design, the wound can be kept dry, and external bacteria can be prevented from invading. The bandage body is further provided with a bandage elastic area which is used for adjusting the tightness of the bandage so as to meet the requirements of different wound parts. 3-6 sensors are arranged on the inner surface of the bandage body and used for monitoring key physiological indexes of a wound in real time, and accurate information is provided for treatment. The intelligent drug delivery module adopts a drug-loaded stimuli-responsive electroactive hydrogel fiber array and is arranged on the inner surface of the bandage body, and accurate drug delivery is achieved through a voltage modulation electrode. The electrical stimulation module adopts a pseudo convergence electric field configuration, is arranged on the inner surface of the bandage body, and is switched between the electrical stimulation electrodes through a timing relay so as to alternately push the wound to be closed. The portable battery supplies power to the portable control module, and the portable control module comprises an integrated microprocessor module, a wireless communication module and a lumped power management module and is connected with the intelligent drug delivery module, the wound monitoring module and the electrical stimulation module to achieve remote monitoring and personalized treatment.
Owner:SHAOXING ZHIBOKANG TECHNOLOGY CO LTD

Precise medication system for hemodialysis patient based on multiple omics and big data

The invention relates to the technical field of medical care informatics and precision medical treatment, and discloses a hemodialysis patient precision medication system based on multiple omics and big data, and the system comprises a multi-source data collection module which collects the multi-source heterogeneous data of a patient and carries out the standardization and integration processing; the drug metabolism analysis module is used for analyzing drug metabolism paths and individual differences through multi-omics data, constructing a drug metabolism polymorphic model and outputting gene metabolism capability grades and biomarker risk tags; the initial medication decision-making module is used for constructing an initial medication decision-making model based on a federal optimization framework of a momentum enhancement and robust aggregation mechanism, and outputting a personalized initial medication scheme for erythropoietin and a vein iron agent; and the drug dosage adjustment module is used for dynamically optimizing the time node and dosage adjustment opportunity of drug administration through an asynchronous federal reinforcement learning framework in combination with a prospective parameter correction strategy. According to the invention, the intelligent medication system with strong robustness and fine decision is constructed.
Owner:YUQING HEMODIALYSIS SERVICE MANAGEMENT GRP CO LTD

Automatic drug delivery system for first aid of hypoglycemic patient

The invention relates to the technical field of medical care informatics, in particular to an automatic drug delivery system for first aid of hypoglycemia patients, comprising: a data acquisition module for acquiring a blood glucose level curve and an acceleration monitoring curve; the evaluation value determination module is used for determining a second evaluation value in an unconscious faint state according to the blood glucose level curve and the acceleration monitoring curve; the intensity value determining module is used for determining the first-aid intensity value of the hypoglycemia patient according to the second evaluation value and the target curve segment of the acceleration monitoring curve; the first-aid operation module is used for providing first-aid operation of the corresponding level for the hypoglycemia patient through the first-aid intensity value. According to the invention, the first-aid intensity value is determined, so that the drug delivery system for first aid makes the corresponding response operation, and the first-aid effect of the hypoglycemia patient is improved.
Owner:YOUAN TECHNOLOGY (NANTONG) CO LTD

Minoxidil film coating agent as well as preparation method and application thereof

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.
Owner:SHANDONG INOMIC INST OF PHARM RES CO LTD

Anesthesia depth self-adaptive regulation and control method and system based on dynamic time sequence model

The invention belongs to the technical field of anesthesia depth regulation and control, and particularly relates to an anesthesia depth self-adaptive regulation and control method and system based on a dynamic time sequence model, and the system comprises a portable computer which is used for operating a program, receiving electroencephalogram time sequence data output by a signal collection device, receiving a pressing event of a handle, and obtaining efficacy information of an effect part; a channel gating result is generated based on the information and used for conducting category division on a drug administration adjustment request, gating is conducted through a shared code LSTM and a two-channel LSTM head and an effect room concentration vector and a hysteresis band, the problem of rhythm dislocation caused by exponential smoothing lag and induction-waking asymmetry is solved, mistaken up-regulation or mistaken down-regulation and overshoot are reduced, and the accuracy of drug administration adjustment is improved. And the adjustment convergence time is shortened, so that the anesthesia depth is more stably maintained in a target interval.
Owner:BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV

Cerebral ischemia drug administration time window intelligent decision-making method

The invention discloses an intelligent decision-making method for a cerebral ischemia drug administration time window, and relates to the technical field of intelligent decision-making. The method comprises the following steps: S1, acquiring parameters, and setting a cerebral ischemia drug configuration scheme; s2, extracting a medicine characteristic parameter set and a medicine taking influence parameter set; s3, calculating a drug combination risk parameter set; s4, performing hierarchical classification processing on the drug combination risk parameter set, and performing drug correlation analysis; s5, performing weighted fusion on a correlation analysis result in combination with a drug influence attenuation rule, generating a drug administration time window evaluation parameter, and adding a label; and S6, according to the parameters, the labels and the configuration scheme, generating a cerebral ischemia drug administration time window intelligent decision scheme, and performing storage and backup. According to the method, by combining directional extraction of the drug characteristic parameter set and the drug taking influence parameter set with Pearson correlation algorithm screening, decision errors caused by data deviation are avoided.
Owner:KUNMING MEDICAL UNIVERSITY

Negative pressure drug delivery dynamic adjusting device for wound surface and use method of negative pressure drug delivery dynamic adjusting device

The invention discloses a negative pressure drug delivery dynamic adjusting device for a wound surface and a using method thereof, and relates to the technical field of medical instruments and equipment.The negative pressure drug delivery dynamic adjusting device comprises a machine shell, a control module, a connecting module, a negative pressure module and a drug delivery module in the wound surface are installed in the machine shell, a collecting chamber is arranged on one side of the bottom of the machine shell, and a pressure stabilizing linkage control mechanism is further arranged in the machine shell; the pressure stabilization linkage control mechanism is used for dynamic regulation and control of negative pressure and drug administration in the wound surface; the connecting module is used for uniform negative pressure of the wound surface and drug administration in the wound surface; according to the scheme, multi-mode free combination is adopted, single negative pressure / in-wound drug delivery, synchronous linkage, reverse linkage and an alternating mode are supported, the full-period requirement from acute trauma to chronic repair is met, and intelligent parameter matching is conducted, for example, through pressure-flow closed-loop feedback, when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced, and when the negative pressure value rises, the drug delivery flow speed in the wound is automatically reduced; when wound exudate is reduced, pulse negative pressure is triggered to promote microcirculation.
Owner:THE PEOPLES HOSPITAL SHAANXI PROV

Anesthesia quantitative spraying equipment for anesthesiology department

The invention relates to the technical field of medical instruments, and discloses anesthesia quantitative spraying equipment for the anesthesiology department. The piston push rod is arranged in the syringe and can slide in the syringe; the injection end head is arranged at the end part of the injection cylinder and is communicated with the injection cylinder; the connecting pipe is arranged at one end of the injection end, and a spraying head is fixedly mounted at one end of the connecting pipe; the injection tube is arranged at the position, close to the injection end head, of the injection cylinder and communicates with the injection cylinder, and the anesthesia quantitative spraying equipment for the anesthesiology department has the advantages that quantification is limited through movement, and compared with the operation mode that manual pressing type equipment depends on the hand force of medical staff, the operation efficiency is greatly improved; dose deviation caused by factors such as operation experience difference and hand fatigue can be effectively avoided, it is ensured that the anesthetic dose injected every time strictly conforms to a preset value, and the consistency of the administration dose is remarkably improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF HEBEI NORTH UNIV

A method, storage chip and device for efficiently evaluating the efficacy of in vitro combined drug administration

The present invention belongs to the field of drug research and development, and specifically discloses a method, storage chip and device for efficiently evaluating the efficacy of in vitro combined drug therapy. The present invention directly solves the problems of complexity and high cost of experiments and data processing in the existing drug development process by adopting an AI model and a simplified experimental mode. The AI ​​model optimizes concentration selection based on historical drug data, thereby reducing redundant concentrations and unnecessary number of experiments in the experiment, and improving the sensitivity and reliability of the evaluation. By simplifying the experimental design to single drug concentration point testing and a 3x3 combined drug matrix, the complexity and cost of the experiment are significantly reduced, while the speed of data processing and analysis is accelerated. The method disclosed in the present invention avoids excessive combined drug pre-testing by directly conducting single drug and 3x3 matrix combined drug testing, which can not only more effectively identify potential synergies between drugs, but also provide more accurate and practical data to support future clinical research.
Owner:CROWN BIOSCIENCE INC (BEIJING)

Ultrasonic scalpel for pediatric surgery

The invention relates to the technical field of ultrasonic scalpels, in particular to an ultrasonic scalpel for pediatric surgery, which comprises a handle part, and a beveling blade surface, a main blade surface and an auxiliary blade surface which are arranged on the handle part, the auxiliary blade face extends from the cutter head end to the tail end to form a second transition blade face, the second transition blade face is designed to be an inwards-concave arc face, an assembling groove is formed in the handle portion, a capsule type flushing head is rotationally installed in the assembling groove in a damping mode, the capsule type flushing head is in a notch shape, and the capsule type flushing head is connected with the auxiliary blade face. The two ends of the capsule type flushing head are the output end and the tail end respectively, an open window communicated with the assembling groove is formed in the outer wall of the arc face of the second transition blade face, the output end of the capsule type flushing head is allowed to rotate out through the open window, and a first straight pipeline is arranged in the handle part in the direction from the cutter handle to the cutter head. The three-effect integrated function of debridement crushing, flushing dosing and waste liquid suction is achieved, flushing dosing can be conducted in time after debridement crushing, and a flushing channel in the tool bit is perfected.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Drug targeted delivery device and method

The invention discloses a drug targeted delivery device and method, and belongs to the technical field of intelligent medical treatment. The device comprises the following modules: an intelligent targeted recognition module for accurately recognizing a gastric cancer specific molecular marker and improving the selectivity and specificity of targeted recognition in combination with a dynamic surface modification strategy; the microenvironment real-time monitoring module is used for monitoring key physiological parameters of the gastric cancer microenvironment in real time; the intelligent path planning module is used for dynamically calculating and optimizing a drug delivery path and realizing accurate drug positioning; the personalized drug administration regulation and control module is used for accurately predicting the drug dosage demand of an individual and dynamically and finely adjusting the drug administration amount in real time; the drug resistance risk management module is used for early warning a drug resistance risk in advance and automatically generating a personalized alternative drug administration strategy through multi-dimensional drug resistance analysis and real-time early warning; and the intelligent drug release module adopts a temperature-sensitive / pH-sensitive polymer shell layer and a nano valve to control drug release, so that precise gradient release of drug concentration is realized.
Owner:SHAANXI CANCER HOSPITAL (SHAANXI INST OF CANCER PREVENTION & TREATMENT) (SHAANXI THIRD PEOPLES HOSPITAL)

Rapamycin multiphase release or osmotic pump type weekly-effect oral controlled-release composition and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, in particular to a rapamycin multiphase release or osmotic pump type weekly-effect oral controlled-release composition and a preparation method thereof, and the rapamycin multiphase release or osmotic pump type weekly-effect oral controlled-release composition comprises a quick release layer, a slow release layer and an osmotic pump structural design. According to the application, staged or constant-rate release of rapamycin within 168 hours is realized through a multi-phase release technology or an osmotic pump technology, and the problems that an existing preparation is large in blood concentration fluctuation, high in administration frequency and low in bioavailability are solved. The composition is suitable for treating hypertrophic cardiomyopathy of cats, significantly improves cardiac functions and reduces side effects and risks, is administered once a week, and is convenient to use. The invention further provides a storage method, and the product stability is ensured. The technical scheme has remarkable clinical advantages and application prospects.
Owner:HUZHOU RUNPET BIOTECHNOLOGY CO LTD

Transdermal drug administration device

A transdermal drug administration device comprises: a housing; a battery; an injection system; a movable connection part for providing fluid connection between the injection system and a reservoir containing an active ingredient intended to be administered; a pump system, the pump system being motorized so as to cause a fluid to circulate within a fluid network of the device; and an electronic system for controlling the driving of the pump system, the electronic system being provided with a mechanical switch for powering the pump system with a battery, wherein the movable connection part is moveable relative to the housing and the reservoir, the movable connection part jointly controlling the fluid supply of the pump and the power supply of the electronic system during the movement, at least part of the movement being performed by a human mechanical action.
Owner:SOCIETE INDUSTRIELLE DE SONCEBOZ SA

Pulmonary artery wedge pressure balloon

ActiveCN223350786UBalloon catheterAngiographyDrug administrationPulmonary artery.wedge
The utility model relates to the technical field of medical instruments, in particular to a pulmonary artery wedge pressure balloon. The pulmonary artery wedge pressure balloon comprises a catheter and a balloon body, one end of the catheter is provided with an inclined and elastic bent section, the balloon body is arranged on the outer wall of the end of the bent section, an airflow cavity channel communicated with an inner cavity of the balloon body is formed in the catheter, and the airflow cavity channel penetrates out of the side wall of the other end of the catheter. The pulmonary artery pressure detector has the advantages that the structural design is simple and reasonable, the use cost is low, and the pulmonary vessel pressure information of a pulmonary artery hypertension patient can be effectively detected, so that medical staff can judge the drug effect of administration according to the information or accurately evaluate the interventional operation of the patient.
Owner:WU HAN SAN LI FANG YI LIAO KE XUE JI SHU YOU XIAN GONG SI

Subcutaneous administration intelligent health management system based on dynamic data

The invention discloses a subcutaneous administration intelligent health management system based on dynamic data, and relates to a medical instrument. According to the system, the data monitoring system, the drug delivery strategy calculation system and the subcutaneous drug delivery system are adopted for monitoring and processing health data and quickly responding to drug intervention, so that the problem that only health data can be monitored and health suggestions can be provided at the present stage, and abnormal health conditions cannot be handled in time is solved; according to the full-automatic management method of'detection, diagnosis and administration ', the compliance of a patient is improved; personalized and intelligent real-time administration calculation is achieved, the effect is guaranteed, meanwhile, the dosage of the medicine is reduced to the maximum extent, and side effects are reduced; the non-invasive transdermal drug delivery performed by using the microneedle system can reduce the problem of low bioavailability of the drug due to the effects of first pass metabolism and the like, and is more friendly to patients with dysphagia.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA +1

Medical information collaborative management and data analysis system and method

The invention discloses a medical information collaborative management and data analysis system and method, relates to the field of intelligent medical treatment, adopts a layered architecture design and realizes application and service separation based on a C / S mode, and the layered architecture comprises a data center layer, a business logic layer and a user interface layer. The medical information collaborative management and data analysis system (MACM) has the remarkable advantages that multi-source data such as UDI, medical insurance, drug administration and HIS billing can be integrated, data islands are broken through a layered architecture and a multi-module design, and cross-department efficient collaboration is achieved; rich automatic tools such as one-key form generation and data preprocessing are provided, manual operation is reduced, and efficiency is improved; the intelligent analysis module can carry out multi-dimensional analysis such as disease consumption ratio calculation and standardized consumption analysis, support refined decision making and comprehensively solve the defects of a traditional system.
Owner:KUNSHAN FIRST PEOPLES HOSPITAL

Construction method and application of depression model

PendingCN120167385AAnimal husbandryHabenular nucleiLateral habenular nucleus
The invention discloses a construction method and application of a depression model. A drug capable of activating neurons in the lateral habenular nucleus brain area to discharge is given to the lateral habenular nucleus area of the brain of the experimental animal, and the depression model is obtained. The invention develops a new method for establishing the depression animal model by utilizing drug induction, local drug administration is performed on the brain of an experimental animal, abnormal discharge activity of neurons of lateral habenula nucleus (LHB) is activated, depression-like behaviors are generated, and the depression-like behaviors are induced to be more stable. Therefore, a new and reliable depression animal model is provided for researching the brain mechanism of depression and researching and developing novel drugs and non-drug intervention methods.
Owner:SHENZHEN INST OF ADVANCED TECH

Cerebral disease drug curative effect analysis and prediction system and method

The invention provides a brain disease drug curative effect analysis and prediction system and method, and relates to the technical field of drug analysis. Multi-source heterogeneous data such as genetic variation spectrum, neural image topological characteristics, metabolic trajectory vectors and microbiome dynamic distribution matrix are integrated, and cross-modal dynamic fusion is realized through decomposition. The system constructs a drug prediction coupling network based on dynamic causal inference, analyzes overlapped potential intervention nodes of multiple disease mechanisms, and generates a disease-drug-phenotype multi-dimensional mapping library. A short-term drug response toxicity threshold is predicted through a metabolic entropy change model, a long-term neurological function degeneration trajectory is evaluated in combination with epigenetic drift, and an anti-fact strategy gradient is utilized to dynamically optimize a drug administration scheme. According to the invention, accurate fusion and dynamic analysis of multi-modal data are realized, a balance mechanism of curative effect and risk is established, and accurate drug combination sequence and administration strategy support can be provided for individualized treatment of complex brain diseases.
Owner:SHENZHEN RUIYU BIOTECHNOLOGY CO LTD

Application of natural-source compound monomer composition in preparation of injection medicine for preventing and / or treating pancreatitis

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.
Owner:FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV

Method and system for collecting and analyzing auditory electrophysiological data of experimental animal

PendingCN120938422AAudiometeringSensorsAuditory thresholdsSurgical operation
The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.
Owner:JOINN LAB (SUZHOU) INC +1

Epidural catheter and epidural space catheterization position detection device

The invention provides an epidural catheter which comprises a first catheter body or a second catheter body, one to five cavities are annularly formed in the end section of the insertion end of the first catheter body at equal intervals around the catheter, and sensors are arranged in the cavities; 1-5 sensors are annularly attached to the outer surface of the end section of the second guide pipe body at equal intervals around the guide pipe, and the outer surface of the second guide pipe body is further coated with a coating. The invention further provides an epidural space catheterization position detection device which comprises an epidural catheter, a connecting tube, a demodulator and an analgesia pump, the demodulator is suitable for converting and displaying signals received by the sensor or conducting early warning, and the demodulator is further suitable for controlling or adjusting drug administration parameters of the analgesia pump according to the received signals; according to the detection device, the position of the epidural catheter in the epidural cavity is judged through an electric signal, epidural administration can be more accurately carried out, and the problems of epidural catheter placement, position monitoring and the like in epidural cavity catheterization are solved.
Owner:THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV

Polymer material, drug-loaded micelle solution, drug-loaded micelle composite hydrogel as well as preparation method and application of polymer material, drug-loaded micelle solution and drug-loaded micelle composite hydrogel

The invention discloses a polymer material, a drug-loaded micelle solution, a drug-loaded micelle composite hydrogel, and a preparation method and application of the drug-loaded micelle composite hydrogel. The polymer material is obtained by reacting oxidized dextran and oleylamine; wherein the oxidized dextran is obtained by oxidizing dextran with the molecular weight of 35000 to 45000; the oxidation degree of the oxidized dextran is 55-70%; the mass ratio of the oxidized dextran to the oleylamine is 1: (1.2-2.0). The polymer material provided by the invention can form a micelle as a carrier to entrap a hydrophobic drug, such as prednisolone. The drug-loaded micelle composite hydrogel provided by the invention can be used for treating inflammatory bowel disease IBD, can avoid damage of an acid environment to a greater extent, and prolongs the administration time.
Owner:INNER MONGOLIA MEDICAL UNIV

Method and apparatus for directional guidance in the performance of a partial vertebrectomy within a cervical spine

A method of providing a guidance device for guiding a bone removal instrument for the removal of bone from a cervical vertebra and providing a vertebral body replacement device for placement into a void in a cervical spine between two endplates of a single vertebra during the course of an anterior spinal surgical procedure upon the cervical spine wherein the vertebral body replacement device has been given a PLR product code from the Food and Drug Administration (FDA).
Owner:SIMONSON ROBERT E

Spray administration device and system for lung diseases

The invention relates to the technical field of medical equipment, in particular to a spray dosing device and system for lung diseases, comprising a shell in which a medicine storage bin for storing liquid medicine and an atomizing component for atomizing and spraying the liquid medicine are mounted, the atomization assembly is communicated with the medicine storage bin, the respiration triggering assembly is installed at the end, away from the medicine storage bin, of the atomization assembly, the airflow adjusting assembly is installed in the atomization assembly, and the atomization assembly is communicated with the medicine storage bin. The airflow adjusting assembly is in signal connection with a controller, and the controller is in signal connection with the atomization assembly and the respiration triggering assembly. The system is used for achieving accurate and intelligent spray administration according to the breathing state of a patient, the deposition efficiency of medicine in the lung is improved, the treatment effect is optimized, and formulation of a personalized treatment scheme is achieved.
Owner:TIANJIN UNIV