The invention discloses a
sodium alginate-beta-
glucan composite wound repair spray with rapid film forming and long-acting repair functions and a preparation method thereof. According to the preparation method,
sodium alginate is subjected to low oxidation degree modification, so that the
sodium alginate and hydroxypropyl methylcellulose with
viscosity gradient regulated and controlled form a high-
ion response composite
system, the obtained spray can quickly form a film after being sprayed, and meanwhile,
yeast beta-
glucan is subjected to
phosphorylation modification, so that the water
solubility and the targeting property are improved; according to the present invention, the
binding force with the macrophage
receptor is enhanced, the anti-inflammatory efficiency is improved, and the ultrasonic-
microwave synergistic swelling, gradient dropwise adding-dynamic shearing cross-linking and other methods are adopted during the preparation, such that the uniformity, the stability and the safety of the product are improved. The obtained spray has multiple effects of rapid film formation, mild bacteriostasis and long-acting repair, can break through vicious circle of
chronic wound repair, and provides an innovative thought for development of wound
nursing products.