The invention relates to a health-care medicated wine and a preparation method thereof. The health-care medicated wine comprises the following components: cervus elaphus linnaeus, spotted deer antler slice, sea horse, kidneys of horse and deer, kidney of donkey, kidney of dog, gecko, herba epimedii, morinda officinalis, Chinese chive seed, dried shrimps, cistanche, the seed of Chinese dodder, babchi seed, flastem milkvetch seed, fenugreek, cinnamon, ootheca mantidis, rhizoma drynariae, honey, crystal sugar and white spirit. In the invention, by adopting the traditional compatibility principle, the health-care medicated wine has the functions of tonifying Qi and strengthening kidney, replenishing essence and nourishing medulla, regulating the balance of Yin and Yang, enhancing sex function, improving immunity and the like, and has the advantages of exquisite material selection, strict preparation process and no bad and side effects.